MODEL0911270006
type: SBMLModel
parameter: 426216
substance units: 573275
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notes: This a model from the article: Circulation: overall regulation. Guyton AC, Coleman TG, Granger HJ. Annu Rev Physiol 1972;34:13-46 4334846 , Abstract: This article is an experiment, one undertaken primarily because of the long-term belief of Dr. Victor Hall, Editor of the Annual Review of Physiology fo r many years, that physiology is, or at least should be, an analytical subject, and that a method not utilized to its fullest advantage for organizing review material is the systems analysis. Furthermore, one of the most likely areas in physiology for which a systems analysis could be of value would be in a discussion of circulatory regulation. Therefore, this article was undertaken directly at the request of the editors of the A ogy to attempt the welding togeth er of a systemsn annuaally Rsiesv ioewf coifr cPuhlaytsoiorlyregulation with a review of the current literature in this field. The systems analysis of circulatory regulation developed for this article is based on earlier, much less extensive analyses (Guyton and Coleman 1, 2); it i s illustrated in Figure 1. This analysis is comprised of 354 blocks, each of which represents one or more mathematical equations describing some physiological facet of circulatory function. In general, each of the functional blocks has been the subject of research investigation by one or many investigator s, but the analysis is based on cumulative knowledge of the circulation rather than simply on current literature. Therefore, the analysis presented here is not a review of the current literature but is a framework to show how the different regulations operate together in the overall system. Later in this review we will attempt to show some of the voids still present in our knowledge of circulatory regulation (which is perhaps the most important value of performing systems analyses), and we will discuss the current research that is attempting to fill these voids. A criticism that has often been made against systems analyses, and ver…
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time units: 577459
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parameter: 426224
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volume units: volume
is described by: http://identifiers.org/pubmed/4334846
parameter: 426226
parameter: 426219
parameter: 426218
parameter: 426223
parameter: 426227
curated: false
name: Guyton1972_HeartRateStrokeVolume
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area units: area

426216
type: Parameter
constant: true
units: dimensionless
value: 4.9943
name: QLO

426222
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUHR

426228
type: Parameter
constant: true
units: dimensionless
value: 0.0
name: PR1LL

426220
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: HMD

426206
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constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

426224
type: Parameter
constant: false
units: dimensionless
value: NaN
name: HDHR

426226
type: Parameter
constant: false
units: dimensionless
value: NaN
name: HR

426219
type: Parameter
constant: true
units: dimensionless
value: 0.00852183
name: PRA

426218
type: Parameter
constant: true
units: dimensionless
value: 1.3
name: AUR

426223
type: Parameter
constant: false
units: dimensionless
value: NaN
name: PRHR

426227
type: Parameter
constant: false
units: dimensionless
value: NaN
name: SVO