MODEL0911270005
type: SBMLModel
parameter: 462479
parameter: 462489
rule: 462401
parameter: 462452
parameter: 462431
parameter: 462441
volume units: volume
notes: This a model from the article: Circulation: overall regulation. Guyton AC, Coleman TG, Granger HJ. Annu Rev Physiol 1972;34:13-46 4334846 , Abstract: This article is an experiment, one undertaken primarily because of the long-term belief of Dr. Victor Hall, Editor of the Annual Review of Physiology fo r many years, that physiology is, or at least should be, an analytical subject, and that a method not utilized to its fullest advantage for organizing review material is the systems analysis. Furthermore, one of the most likely areas in physiology for which a systems analysis could be of value would be in a discussion of circulatory regulation. Therefore, this article was undertaken directly at the request of the editors of the A ogy to attempt the welding togeth er of a systemsn annuaally Rsiesv ioewf coifr cPuhlaytsoiorlyregulation with a review of the current literature in this field. The systems analysis of circulatory regulation developed for this article is based on earlier, much less extensive analyses (Guyton and Coleman 1, 2); it i s illustrated in Figure 1. This analysis is comprised of 354 blocks, each of which represents one or more mathematical equations describing some physiological facet of circulatory function. In general, each of the functional blocks has been the subject of research investigation by one or many investigator s, but the analysis is based on cumulative knowledge of the circulation rather than simply on current literature. Therefore, the analysis presented here is not a review of the current literature but is a framework to show how the different regulations operate together in the overall system. Later in this review we will attempt to show some of the voids still present in our knowledge of circulatory regulation (which is perhaps the most important value of performing systems analyses), and we will discuss the current research that is attempting to fill these voids. A criticism that has often been made against systems analyses, and ver…
parameter: 462483
rule: 462422
rule: 462414
parameter: 462493
parameter: 462432
parameter: 462500
parameter: 462485
parameter: 462496
parameter: 462456
rule: 462405
parameter: 462435
parameter: 462445
area units: area
rule: 462424
parameter: 462477
curated: false
parameter: 462442
parameter: 462454
rule: 462398
rule: 462394
rule: 462418
rule: 462421
rule: 462411
parameter: 462467
rule: 462413
parameter: 462440
rule: 462403
rule: 462409
parameter: 462480
parameter: 462491
is described by: http://identifiers.org/pubmed/4334846
parameter: 462470
parameter: 462495
parameter: 462438
parameter: 462446
parameter: 462487
parameter: 462458
parameter: 462449
parameter: 462484
parameter: 462497
parameter: 462488
name: Guyton1972_Autonomics
parameter: 462463
rule: 462417
rule: 462407
parameter: 462504
parameter: 462478
parameter: 462460
parameter: 462428
parameter: 462464
rule: 462426
parameter: 462501
rule: 462395
parameter: 462451
parameter: 462505
substance units: 573275
parameter: 462455
rule: 462397
parameter: 462430
rule: 462420
rule: 462410
time units: 577459
rule: 462402
parameter: 462492
parameter: 462471
parameter: 462481
parameter: 462444
parameter: 462468
parameter: 462499
parameter: 462459
length unit: 027038

462479
type: Parameter
constant: true
units: dimensionless
value: 0.0
name: AUY

462489
type: Parameter
constant: true
units: dimensionless
value: 0.4
name: AUMIN

462452
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUEX

462431
type: Parameter
constant: true
units: dimensionless
value: 2.0
name: PLA

462441
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AU6C

462483
type: Parameter
constant: true
units: dimensionless
value: 0.1
name: O2A

462493
type: Parameter
constant: true
units: dimensionless
value: 0.01
name: EXCML

462432
type: Parameter
constant: true
units: dimensionless
value: 0.00852183
name: PRA

462500
type: Parameter
constant: true
units: dimensionless
value: 0.004
name: AUK

462485
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: AUM2

462496
type: Parameter
constant: true
units: dimensionless
value: 0.5
name: AUN1

462456
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AU

462435
type: Parameter
constant: false
units: dimensionless
value: NaN
name: PA1

462445
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AU6A

462477
type: Parameter
constant: true
units: dimensionless
value: 1.5
name: AUL

462442
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUB

462454
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUTTL

462467
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUM

462440
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUC2

462480
type: Parameter
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units: dimensionless
value: 0.55
name: AUV

462491
type: Parameter
constant: true
units: dimensionless
value: 1.5
name: AUSLP

462470
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUO

462495
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: EXCXP

462438
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUC3

462446
type: Parameter
constant: true
units: dimensionless
value: -0.060024
name: AU4

462487
type: Parameter
constant: true
units: dimensionless
value: 0.3
name: AUDMP

462458
type: Parameter
constant: false
units: dimensionless
value: NaN
name: DAU

462449
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUN

462484
type: Parameter
constant: true
units: dimensionless
value: 3.0
name: AUM1

462497
type: Parameter
constant: true
units: dimensionless
value: 0.0
name: MDMP

462488
type: Parameter
constant: true
units: dimensionless
value: 5.0
name: AUMAX

462463
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUH

462504
type: Parameter
constant: true
units: dimensionless
value: 0.3
name: AUC1

462478
type: Parameter
constant: true
units: dimensionless
value: 0.0
name: AULPM

462460
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUT

462428
type: Parameter
constant: true
units: dimensionless
value: 103.525
name: PA

462464
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUR

462501
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: AUX

462451
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AULP

462505
type: Parameter
constant: true
units: dimensionless
value: 0.0
name: CRRFLX

462455
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUTTL1

462430
type: Parameter
constant: true
units: dimensionless
value: 97.0439
name: PO2ART

462492
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: EXC

462471
type: Parameter
constant: true
units: dimensionless
value: 2.51
name: VV9

462481
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: AUS

462444
type: Parameter
constant: false
units: dimensionless
value: NaN
name: A1B

462468
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AVE

462499
type: Parameter
constant: true
units: dimensionless
value: 0.16
name: BAROTC

462459
type: Parameter
constant: false
units: dimensionless
value: 1.00007
name: AU1

462434
type: Parameter
constant: true
units: dimensionless
value: 15.6376
name: PPA

462448
type: Parameter
constant: false
units: dimensionless
value: 1.00132
name: AU6

462437
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AUC

462390
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

462462
type: Parameter
constant: false
units: dimensionless
value: NaN
name: VVR

462466
type: Parameter
constant: false
units: dimensionless
value: NaN
name: AOM

462503
type: Parameter
constant: true
units: dimensionless
value: 0.01
name: O2CHMO

462507
type: Parameter
constant: true
units: dimensionless
value: 0.0
name: EXE