MODEL0848062679
type: SBMLModel
substance units: 469466
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parameter: 661268
notes: This a model from the article: Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation. Irvine LA, Jafri MS, Winslow RL. Biophys J 1999 Apr;76(4):1868-85 10096885 , Abstract: A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819-829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential functions of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets. The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10 degrees C to 25 degrees C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Irvine LA, Jafri MS, Winslow RL. (1999) - version02 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you de…
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is described by: http://identifiers.org/pubmed/10096885
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name: Irvine1999_CardiacSodiumChannel
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