MODEL0491251823
type: SBMLModel
parameter: 112619
rule: 112539
parameter: 112579
parameter: 112603
parameter: 112623
curated: false
parameter: 112595
parameter: 112605
parameter: 112565
rule: 112553
units def: 473657
parameter: 112581
rule: 112541
parameter: 112563
parameter: 112583
area units: area
length unit: 222721
rule: 112557
parameter: 112601
parameter: 112589
parameter: 112573
parameter: 112593
rule: 112549
rule: 112543
parameter: 112615
parameter: 112575
parameter: 112617
is described by: http://identifiers.org/pubmed/17320763
parameter: 112591
units def: 473693
units def: 473766
parameter: 112561
parameter: 112625
rule: 112547
rule: 112545
parameter: 112607
parameter: 112627
compartment: 112530
time units: 469490
substance units: 469466
parameter: 112599
parameter: 112609
rule: 112532
name: Chen2007_NeuronalEndothelialNOS
units def: 473717
parameter: 112569
rule: 112551
parameter: 112613
rule: 112555
parameter: 112585
rule: 112537
parameter: 112567
parameter: 112560
parameter: 112587
parameter: 112611
parameter: 112571
volume units: volume
rule: 112559
parameter: 112577
rule: 112535
parameter: 112597
parameter: 112621
notes: This a model from the article: Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). Chen K, Popel AS Free Radic Biol Med. 2007 Mar 15;42(6):811-22. 17320763 , Abstract: Nitric oxide (NO) derived from nitric oxide synthase (NOS) is an important paracrine effector that maintains vascular tone. The release of NO mediated by NOS isozymes under various O(2) conditions critically determines the NO bioavailability in tissues. Because of experimental difficulties, there has been no direct information on how enzymatic NO production and distribution change around arterioles under various oxygen conditions. In this study, we used computational models based on the analysis of biochemical pathways of enzymatic NO synthesis and the availability of NOS isozymes to quantify the NO production by neuronal NOS (NOS1) and endothelial NOS (NOS3). We compared the catalytic activities of NOS1 and NOS3 and their sensitivities to the concentration of substrate O(2). Based on the NO release rates predicted from kinetic models, the geometric distribution of NO sources, and mass balance analysis, we predicted the NO concentration profiles around an arteriole under various O(2) conditions. The results indicated that NOS1-catalyzed NO production was significantly more sensitive to ambient O(2) concentration than that catalyzed by NOS3. Also, the high sensitivity of NOS1 catalytic activity to O(2) was associated with significantly reduced NO production and therefore NO concentrations, upon hypoxia. Moreover, the major source determining the distribution of NO was NOS1, which was abundantly expressed in the nerve fibers and mast cells close to arterioles, rather than NOS3, which was expressed in the endothelium. Finally, the perivascular NO concentration predicted by the models under conditions of normoxia was paradoxically at least an order of magnitude lower than a number of exper…
rule: 112533

112619
type: Parameter
constant: true
units: 473693
value: 399.2
name: k_9

473693
type: SBMLUnitsDef
unit: 473705
name: first_order_rate_constant

473705
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

112579
type: Parameter
constant: false
units: 473657
value: 0.0
name: NO

473657
type: SBMLUnitsDef
unit: 473681
unit: 473669
name: micromolar

473681
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

473669
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

112603
type: Parameter
constant: true
units: 473693
value: 6.6
name: k_4

112623
type: Parameter
constant: true
units: 473693
value: 20.8
name: k11

112595
type: Parameter
constant: true
units: 473693
value: 6.6
name: k_1

112605
type: Parameter
constant: true
units: 473717
value: 8.5
name: k5

473717
type: SBMLUnitsDef
unit: 473753
unit: 473741
unit: 473729
name: second_order_rate_constant

473753
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

473741
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

473729
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

112565
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe2_Arg

112581
type: Parameter
constant: false
units: 473766
value: NaN
name: dNOdt

473766
type: SBMLUnitsDef
unit: 473803
unit: 473790
unit: 473778
name: micromolar_per_second

473803
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

473790
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

473778
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

112563
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe2

112583
type: Parameter
constant: false
units: 473657
value: 0.0
name: citrulline

112601
type: Parameter
constant: true
units: 473717
value: 6.6
name: k4

112589
type: Parameter
constant: true
units: 473657
value: 100.0
name: O2

112573
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe3_O2_NOHA

112593
type: Parameter
constant: true
units: 473717
value: 6.6
name: k1

112615
type: Parameter
constant: true
units: 473693
value: 13.2
name: k_8

112575
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe3_NO

112617
type: Parameter
constant: true
units: 473717
value: 8.6
name: k9

112591
type: Parameter
constant: true
units: 473657
value: 100.0
name: Arg

112561
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe3_Arg

112625
type: Parameter
constant: true
units: 473717
value: 0.01
name: k12

112607
type: Parameter
constant: true
units: 473693
value: 215.6
name: k_5

112627
type: Parameter
constant: true
units: 473693
value: 39.9
name: k13

112530
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

112599
type: Parameter
constant: true
units: 473693
value: 20.8
name: k3

112609
type: Parameter
constant: true
units: 473693
value: 175.6
name: k6

112569
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe3_NOHA

112613
type: Parameter
constant: true
units: 473717
value: 13.2
name: k8

112585
type: Parameter
constant: false
units: 473657
value: 0.0
name: NO3

112567
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe3_O2_Arg

112560
type: Parameter
constant: false
units: 473657
value: 0.3
name: Fe3

112587
type: Parameter
constant: false
units: 473657
value: 0.0
name: NOHA

112611
type: Parameter
constant: true
units: 473693
value: 20.8
name: k7

112571
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe2_NOHA

112577
type: Parameter
constant: false
units: 473657
value: 0.0
name: Fe2_NO

112597
type: Parameter
constant: true
units: 473693
value: 20.8
name: k2

112621
type: Parameter
constant: true
units: 473693
value: 39.1
name: k10