2-methylpropanal transport (mitochondrial)
SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
2-oxo-4-methyl-3-carboxypentanoate decarboxylation
Nicotinamide adenine dinucleotide phosphate
Nicotinamide adenine dinucleotide phosphate - reduced
D-fructose transport in via proton symport
SUBSYSTEM: Tyrosine, Tryptophan, and Phenylalanine Metabolism
L-tryptophan transport via proton symport
Ceramide-2 synthase (24C), endoplasmic reticular
5-diphosphoinositol-1,2,3,4,6-pentakisphosphate synthase
ornithine mitochondrial transport via proton antiport
aldehyde dehydrogenase (2-phenylethanol, NAD), mitochondrial
Nicotinamide adenine dinucleotide - reduced
SUBSYSTEM: Transport, Endoplasmic Reticular
6-phospho-D-glucono-1,5-lactone endoplasmic reticular transport via diffusion
aldehyde dehydrogenase (tryptophol, NAD), mitochondrial
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
carbamoyl-phosphate synthase (glutamine-hydrolysing)
SUBSYSTEM: Arginine and Proline Metabolism
arginine mitochondrial transport via proton symport
pyruvate decarboxylase (acetoin-forming)
Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
5,10-methylenetetrahydrofolatereductase (NADPH)
cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)
D-mannose transport in via proton symport
hydrogen peroxide reductase (thioredoxin), peroxisomal
Thiamine transport in via proton symport
3-Octaprenyl-4-hydroxybenzoate mitochondrial transport
asparagine synthase (glutamine-hydrolysing)
SUBSYSTEM: Alanine and Aspartate Metabolism
4-aminobutanoate mitochondrial transport via diffusion
D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate
farnesyl diphosphate transport (mitochondrial)
Thiamine diphosphate transport, mitochondria
4-hydroxy-2-oxoglutarate mitochondrial transport via diffusion
acyl-CoA oxidase (octadecanoyl-CoA), peroxisomal
sphinganine 1-phosphate endoplasmic reticular transport
glycerol-3-phosphate dehydrogenase (NAD)
L-isoleucine transport via proton symport
YBR127C, YDL185W, YEL027W, YEL051W, YGR020C, YHR026W, YHR039C-A, YKL080W, YLR447C, YMR054W, YOR332W, YPL234C, YPR036W
1D-myo-Inositol 1,3,4,5-tetrakisphosphate
methylenetetrahydrofolate dehydrogenase (NAD)
4-aminobutyrate transport in via proton symport
N-acetylglucosamine-6-phosphate synthase
3,4-Dihydroxy-2-butanone-4-phosphate synthase
Squalene epoxidase, endoplasmic reticular (NAD)
aldehyde dehydrogenase (tryptophol, NAD)
Dolichyl-phosphate-mannose--protein mannosyltransferase, endoplasmic reticular
ribonucleoside-diphosphate reductase (GDP), nuclear
L-threonine transport via proton symport
alcohol dehydrogenase, reverse rxn (acetaldehyde -> ethanol)
SUBSYSTEM: Purine and Pyrimidine Biosynthesis
3',5'-cyclic-nucleotide phosphodiesterase
glyceraldehyde-3-phosphate dehydrogenase
isoamyl alcohol transport (mitochondrial)
SUBSYSTEM: Glycine and Serine Metabolism
Ceramide-1 synthase (26C), endoplasmic reticular
SUBSYSTEM: Starch and Sucrose Metabolism
D-galactose transport in via proton symport
L-isoleucine transport in via proton antiport (vacuolar)
5-Methylthio-5-deoxy-D-ribulose 1-phosphate
5-Methylthio-5-deoxy-D-ribose 1-phosphate
5-methylthioribose-1-phosphate isomerase
inositol transport in via proton symport
N-acteylglutamate synthase, mitochondrial
ribonucleoside-diphosphate reductase (CDP)
oxidized thioredoxin peroxisomal transport via diffusion
acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
Ceramide-2 synthase (26C), endoplasmic reticular
acid phosphatase, extracellular (secreted)
reduced thioredoxin peroxisomal transport via diffusion
fatty-acyl-ACP synthase (n-C16:0ACP), mitochondrial
UTP-glucose-1-phosphate uridylyltransferase
3-methyl-2-oxobutanoate hydroxymethyltransferase
SUBSYSTEM: Pantothenate and CoA Biosynthesis
L-methionine transport via proton symport
alpha,alpha-trehalose-phosphate synthase (UDP-forming)
aldehyde dehydrogenase (isobutyl alcohol, NADP)
Dihydropteroate mitochondrial transport via diffusion
protoporphyrinogen oxidase, mitochondrial
SUBSYSTEM: Porphyrin and Chlorophyll Metabolism
Adenosine 3',5'-bisphosphate mitochondrial transport
aldehyde dehydrogenase (isoamyl alcohol, NAD)
glycylpeptide N-tetradecanoyltransferase
succinate dehydrogenase (ubiquinone-6), mitochondrial
aldehyde dehydrogenase (3-aminopropanal, NAD)
nicotinate-nucleotide diphosphorylase (carboxylating)
2-dehydropantoate 2-reductase, mitochondrial
L-carnitine transport out of mitochondria via diffusion
2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
phosphoribosylaminoimidazolesuccinocarboxamide synthase
isobutyl alcohol transport (mitochondrial)
Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
SUBSYSTEM: Fructose and Mannose Metabolism
Squalene-2,3-epoxide endoplamic reticular transport
cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)
hydrogen peroxide reductase (thioredoxin), mitochondrial
alkaline ceramidase (ceramide-2), endoplasmic reticulum
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, peroxisomal
5-diphosphoinositol-1,2,3,4,6-pentakisphosphate diphosphohydrolase
L-histidine transport in via proton antiport (vacuolar)
hypoxanthine transport via proton symport
GTP/GDP translocase, mitochondrial (electroneutral)
Itaconate--CoA ligase (ADP-forming), mitochondrial
fatty acid peroxisomal transport via ABC system
2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
trehalose transport in via proton symporter
N-carbomoyl-L-aspartate transport, diffusion
serine mitochondrial transport via proton symport
glycine-cleavage complex (lipoamide), mitochondrial
L-leucine transport out via proton symport, vacuolar
Ferrocytochrome-c:hydrogen-peroxide oxidoreductase
bicarbonate nuclear transport via diffusion
fatty-acyl-ACP synthase (n-C14:0ACP), mitochondrial
cytochrome P450 lanosterol 14-alpha-demethylase (NAD)
Homocysteine peroxisomal transport via proton symport
aldehyde dehydrogenase (2-phenylethanol, NAD)
Dihydroneopterin monophosphate dephosphorylase
dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate), mitochondrial
mannan endoplasmic reticulum transport via diffusion
nicotinamide-nucleotide adenylyltransferase
succinate-fumarate transport, mitochondrial
2-oxoadipate and 2-oxoglutarate transport
sucrose hydrolyzing enxyme, extracellular
panthetheine-phosphate adenylyltransferase
Phenylalanine mitochondrial transport via proton symport
Reduced glutathione via ABC system (vacuolar)
Isoamyl acetate transport (extracellular)
SUBSYSTEM: Threonine and Lysine Metabolism
Alanine transport from mitochondia to cytoplasm
acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
Alcohol Acetyltransferase (2-methylbutanol)
Ergosta-5,6,22,24,(28)-tetraen-3beta-ol endoplamic reticular transport
fatty-acyl-ACP synthase (n-C12:0ACP), mitochondrial
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA), peroxisomal
inositol-1,4,5,6- tetrakisphosphate 3-kinase, nucleus
1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
1D-myo-Inositol 1,4,5,6-tetrakisphosphate
(S)-Lactate:ferricytochrome-c 2-oxidoreductase
C-s24 sterol reductase, endoplamic reticular
sphingoid base-phosphate phosphatase (sphinganine 1-phosphatase), endoplasmic reticulum
phosphopantothenoylcysteine decarboxylase
N-acetylputrescine: oxygen oxireductase (deaminating)
L-lysine transport in via proton antiport (vacuolar)
acyl carrier protein synthase, mitochondrial
ceramide-1 (C26) endoplasmic reticular transport
fatty-acid--CoA ligase (decanoate), peroxisomal
ceramide-2 (C26) endoplasmic reticular transport
O-succinylhomoserine lyase (elimination)
L-glutamine transport in via proton antiport (vacuolar)
carnithine-acetylcarnithine carrier, mitochondrial
citrate/isocitrate antiport into peroxisome
phosphate nuclear transport via proton symport
Ceramide-1 synthase (24C), endoplasmic reticular
pyruvate transport in via proton symport
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
oxoglutarate dehydrogenase (dihydrolipoamide S-succinyltransferase)
fatty-acid--CoA ligase (hexadecenoate), peroxisomal
cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)
carnitine O-acetyltransferase, reverse direction, peroxisomal
aldehyde dehydrogenase (isobutyl alcohol, NAD), mitochondrial
aspartate mitochondrial transport via proton symport
C-3 sterol keto reductase (4-methylzymosterol)
acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
C-4 sterol methyl oxidase (4-methylzymosterol)
5-Aminolevulinate transport in via proton symport
fatty acid oxidation (octanoyl-CoA), peroxisomal
Myristicoyl-CoA desaturase (n-C14:0CoA -> n-C14:1CoA)
purine-nucleoside phosphorylase (Xanthosine)
L-arginine transport in via proton antiport (vacuolar)
L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
YGL205W, YIL160C, YKR009C, YLR284C, YNL202W, YOR180C
cytidine transport in via proton symport
L-glutamate transport via proton symport
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
spermidine transport in via proton antiport
3-(4-hydroxyphenyl)pyruvate peroxisomal transport via proton symport
Tryptophanyl-tRNA synthetase, mitochondrial
Alcohol Acetyltransferase (Phenylethanol alcohol)
S-adenosyl-L-homocysteine transport, mitochondrial
3-Carboxy-4-methyl-2-oxopentanoate transport, diffusion, mitochondrial
xanthosine transport in via proton symport
L-tyrosine transport in via proton antiport (vacuolar)
xylitol dehydrogenase (D-xyulose-forming)
cytosine transport in via proton symport
Alcohol Acetyltransferase (isoamyl alcohol)
ergosterol endoplasmic reticular transport
methylenetetrahydrofolate dehydrogenase (NADP)
YBR127C, YDL185W, YEL027W, YEL051W, YGR020C, YHR026W, YHR039C-A, YKL080W, YLR447C, YOR270C, YOR332W, YPL234C, YPR036W
inositol-1,3,4,5-triphosphate 6-kinase, nucleus
aldehyde dehydrogenase (indole-3-acetaldehyde, NADP), mitochondrial
3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
aldehyde dehydrogenase (2-methylbutanol, NAD)
aldehyde dehydrogenase (isobutyl alcohol, NAD)
2-methyl-1-butanol transport (extracellular)
ribonucleoside-diphosphate reductase (UDP)
nicotinate-nucleotide adenylyltransferase
2-keto-4-methylthiobutyrate transamination
L-aspartate transport via proton symport
coproporphyrinogen oxidase (O2 required)
D-erythrose 4-phosphate mtiochondrial transport via diffusion
isoamyl alcohol transport (extracellular)
spermidine excretion (cytosol to extracellular)
trans-4-hydroxy-L-proline mitochondrial transport via diffusion
3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA), peroxisomal
inositol-1,4,5-triphosphate 6-kinase, nucleus
Isopentenyl diphosphate transport, mitochondrial
2-Dehydropantoate mitochondrial transport
C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, mitochondrial
acyl-CoA oxidase (decanoyl-CoA), peroxisomal
nucleoside-diphosphate kinase (ATP:dADP)
stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
formate dehydrogenase, cytosolic/mitochondrial
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase
purine-nucleoside phosphorylase (Deoxyinosine)
histidine mitochondrial transport via proton symport
L-phenylalanine transport via proton symport
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
hydroxyacylglutathione hydrolase, mitochondrial
thiazole phosphate synthesis (ribose 5-phosphate), yeast-specifc
ribonucleoside-triphosphate reductase (GTP)
Octadecenoate (n-C18:1) transport in via uniport
2-isopropylmalate synthase, mitochondrial
ribonucleoside-triphosphate reductase (UTP)
ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate), mitochondrial
isoleucyl-tRNA synthetase, mitochondrial
L-glutamine transport via proton symport
saccharopine dehydrogenase (NADP, L-glutamate forming)
dihydroxyacetone phosphate transport, mitochondrial
deoxyadenosine transport in via proton symport
tryptophan synthase (indoleglycerol phosphate)
glycine-cleavage complex (lipoylprotein), mitochondrial
fatty acyl-CoA peroxisomal transport via ABC system
ribonucleoside-diphosphate reductase, nuclear
deoxyguanosine transport in via proton symport
CO2 transport (diffusion), mitochondrial
Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase
formate-tetrahydrofolate ligase, mitochondrial
P1-(5'-adenosyl),P4-(5'-guanosyl) tetraphosphate
2-Isopropylmalate transport, diffusion, mitochondrial
L-asparagine transport via proton symport
deoxyhypusine synthase, cytosolic/mitochondrial
pantetheine-phosphate adenylyltransferase
phenylalanyl-tRNA synthetase, mitochondrial
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
glycine mitochondrial transport via proton symport
Hydroxymethylglutaryl-CoA mitochondrial transport
5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
Glycolipid 1,3-alpha-D-mannosyltransferase, Golgi apparatus
ribose transport in via proton symporter
fatty-acid--CoA ligase (tetradecenoate), peroxisomal
3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA), peroxisomal
S-adenosyl-methionine delta-24-sterol-c-methyltransferase
aldehyde dehydrogenase (indole-3-acetaldehyde, NADP)
fatty acid synthase (n-C8:0), lumped reaction
aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
asparagine mitochondrial transport via proton transport
2-Methylbutanal transport (mitochondrial)
L-glutamate transport into mitochondria via hydroxide ion antiport
purine-nucleoside phosphorylase (Deoxyadenosine)
phytosphinganine 1-phosphate endoplasmic reticular transport
purine-nucleoside phosphorylase (Guanosine), mitochondrial
glycerol-3-phosphate dehydrogenase (NAD), mitochondrial
L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
orntithine transport in via proton symport
ribonucleoside-diphosphate reductase (UDP), nuclear
3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA), peroxisomal
S-adenosyl-L-methionine transport in via proton symport
fatty-acid--CoA ligase (n-C24:0), peroxisomal
3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA), peroxisomal
fatty-acyl-ACP synthase (n-C16:1ACP), mitochondrial
E-3-carboxyl-2-pentenedioate 5-methyl ester
AMP transport via diffusion (cytosol to nucleus)
fatty-acyl-ACP synthase (n-C18:2ACP), mitochondrial
2-oxoadipate transport out of mitochondria via diffusion
N,N-bisformyl-dityrosine transport (extracellular)
5-formethyltetrahydrofolate cyclo-ligase, mitochondrial
YGL205W, YIL160C, YKR009C, YLR284C, YNL202W
3-Hexaprenyl-4,5-dihydroxybenzoate hydroxylase, mitochondrial
Valine mitochondrial transport via proton symport
diphosphoinositol-1,3,4,6-tetrakisphosphate synthase
4-amino-5-hydroxymethyl-2-methylpyrimidine synthetase
Phenylacetaldehyde transport (mitochondrial)
acetohydroxy acid isomeroreductase, mitochondrial
ribonucleoside-diphosphate reductase (ADP)
Aminobutyraldehyde dehydrogenase, mitochondrial
fatty-acyl-ACP synthase (n-C14:1ACP), mitochondrial
2-Hexaprenyl-6-methoxyphenol monooxygenase, mitochondrial
ribonucleoside-diphosphate reductase (GDP)
L-asparagine transport out via proton symport, vacuolar
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
aldehyde dehydrogenase (2-methylbutanol, NAD), mitochondrial
L-tyrosine transport out via proton symport, vacuolar
L-isoleucine transport out via proton symport, vacuolar
cytochrome P450 lanosterol 14-alpha-demethylase (NADP)
hexadecenoate (n-C16:1) transport in via uniport
aldehyde dehydrogenase (2-methylbutanol, NADP)
Lysine mitochondrial transport via proton symport
ribonucleoside-diphosphate reductase (CDP), nuclear
D-sorbitol transport via passive diffusion
purine-nucleoside phosphorylase (Adenosine), mitochondrial
nicotinate-nucleotide adenylyltransferase, mitochondrial
fatty-acid--CoA ligase (dodecanoate), peroxisomal
tyrosine mitochondrial transport via proton symport
3-methylbutanal transport (mitochondrial)
isobutyl alcohol transport (extracellular)
tetrahydrofolate aminomethyltransferase, mitochondrial
L-histidine transport via proton symport
1-alpha-D-Galactosyl-myo-inositol galactohydrolase
urea transport via proton symport (2 H+)
Isoleucine transport from mitochondria to cytosol
threonine mitochondrial transport via proton symport
acetyl-CoA acyltransferase (hexadecanoyl-CoA), peroxisomal
2-hydroxybutyrate cotransport with proton
YGL205W, YIL160C, YKR009C, YNL202W, YOR180C
phosphoribosylaminoimidazolecarboxamide formyltransferase
D-lactate/pyruvate antiport, mitochondrial
Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
NADH dehydrogenase, cytosolic/mitochondrial
tyrosine peroxisomal transport via proton symport
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (nadph)
cholestenol delta-isomerase, lumped reaction
carnitine O-aceyltransferase, mitochondrial
glutamine phosphoribosyldiphosphate amidotransferase
5-formethyltetrahydrofolate cyclo-ligase
dolichol phosphate endoplasmic reticular transport via proton symport
diphosphoinositol-1,3,4,6-tetrakisphosphate diphosphohydrolase
indole-3-acetaldehyde mitochondrial transport via diffusion
Malonyl-CoA-ACP transacylase, mitochondrial
L-aspartate transport out via proton symport, vacuolar
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
carbamoyl phosphate nuclear transport via diffusion
fatty acid synthase (n-C24:0), lumped reaction
ceramide-1 (C24) endoplasmic reticular transport
L-arabinitol transport via passive diffusion
hexaprenyldihydroxybenzoate methyltransferase
tryptophan mitochondrial transport via proton symport
aldehyde dehydrogenase (2-phenylethanol, NADP)
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
UDPglucose--hexose-1-phosphate uridylyltransferase
all-trans-Pentaprenyl diphosphate transport, mitochondrial
putrescine excretion (cytosol to extracellular)
D1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
3-phosphoshikimate 1-carboxyvinyltransferase
Glutamate transport (uniporter), mitochondrial
4-hydroxy-2-oxoglutarate peroxisomal transport via diffusion
acyl-CoA oxidase (hexacanoyl-CoA), peroxisomal
ethanolamine transport via diffusion (extracellular)
guanosine mitochondrial transport via proton symport
D-sorbitol dehydrogenase (D-fructose producing)
galactose-1-phosphate uridylyltransferase
fatty acid oxidation (tetradecansoyl-CoA), peroxisomal
acetylcarnitine transport out of peroxisome
protoporphyrinogen IX mitochondrial transport
alkaline ceramidase (ceramide-1), endoplasmic reticulum
sphingolipid long chain base kinase (phytosphingosine)
asparaginyl-tRNA synthetase, miotchondrial
fatty-acyl-ACP synthase (n-C18:0ACP), mitochondrial
3-Hexaprenyl-4-hydroxy-5-methoxybenzoate decarboxylase, mitochondrial
uroporphyrinogen decarboxylase (uroporphyrinogen III)
O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase
3-methylbutanal transport (extracellular)
Methionyl-tRNA formyltransferase, mitochondrial
pyruvate peroxisomal transport via proton symport
2-oxoglutarate nuclear transport via proton symport
3-methyl-2-oxobutanoate transport, diffusion, mitochondrial
aldehyde dehydrogenase (isoamyl alcohol, NADP)
acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
UDP-glucose:ergosterol glucosyltransferase
fatty-acyl-ACP synthase (n-C10:0ACP), mitochondrial
adenosylmethionine-8-amino-7-oxononanoate transaminase
L-2-amino-3-oxobutanoate decarboxylation (spontaneous)
YAL044C, YBR221C, YDR019C, YER178W, YMR189W
3-(4-hydroxyphenyl)pyruvate mitochondrial transport via proton symport
Phenethyl acetate transport (extracellular)
3-Methyl-2-oxopentanoate transport, diffusion, mitochondrial
2-Dehydro-3-deoxy-D-arabino-heptonate7-phohsphate mitochondrial transport via diffusion
Indoleacetaldehyde transport (extracellular)
inositol hexakisphosphate nuclear transport (diffusion)
acyl-CpA oxidase (tetradecanoyl-CoA), peroxisomal
L-aminoadipate-semialdehyde dehydrogenase (NADH)
methenyltetrahydrifikate cyclohydrolase, mitochondrial
(R)-Lactate:ferricytochrome-c 2-oxidoreductase
Dihydroneopterin triphosphate pyrophosphatase
2-methylcitrate dehydratase, mitochondrial
3-Hexaprenyl-4,5-dihydroxybenzoate transport, mitochondrial
NMN peroxisomal transport via proton symport
Octadecanoate (n-C18:0) transport in via uniport
phosphoadenylyl-sulfate reductase (thioredoxin)
Alcohol Acetyltransferase (isobutyl alcohol)
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
Hexadecanoate (n-C16:0) transport in via uniport
L-cystine transport via proton symport (vacuolar)
nucleoside-diphosphate kinase (ATP:dGDP)
2-methylpropanal transport (extracellular)
ribonucleoside-triphosphate reductase (ATP)
nucleoside-diphosphate kinase (ATP:dCDP)
Hydroxymethylglutaryl CoA synthase, mitochondrial
ribonucleoside-triphosphate reductase (CTP)
aldehyde dehydrogenase (phenylacetaldehyde, NAD)
carnitine-acetylcarnitine carrier, peroxisomal
deoxyinosine transport in via proton symport
Isobutyl acetate transport (extracellular)
Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
L-hydroxyproline dehydrogenase (NAD), mitochondrial
pyruvate mitochondrial transport via proton symport
hydrogen peroxide reductase (thioredoxin)
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase
1D-myo-Inositol 1,4,5-trisphosphate nuclear transport via diffusion
YDR204W, YGL119W, YGR255C, YLR201C, YML110C, YOL096C, YOR125C
indole-3-acetate mitochondrial transport via diffusion
methionine mitochondrial transport via proton symport
thiazole phosphate synthesis (xylulose 5-phosphate), yeast-specific
L-glutamate 5-semialdehyde dehydratase,, mitochondrial
ammonia transport (efflux, cytosol to extracellular)
L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
Dolichyl-phosphate D-mannosyltransferase
succinate-semialdehyde dehydrogenase (NADP)
hypoxanthine phosphoribosyltransferase (Hypoxanthine)
L-aspartate nuclear transport via diffusion
acyl-CoA oxidase (dodecanoyl-CoA), peroxisomal
3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA), peroxisomal
4-Aminobenzoate mitochondrial transport via diffusion
inositol-1,3,4,5,6-pentakisphosphate 2-kinase, nuclear
7,8-Diaminononanoate transport via proton symport
Glycogen vacuolar 'transport' via autophagy
fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
acteylornithine transaminase, mitochondrial
YBR221C, YER178W, YFL018C, YGR193C, YNL071W
dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate), mitochondrial
UDPgalactose transport (Golgi apparatus)
glutamine nuclear transport via proton symport
2-aceto-2-hydroxybutanoate synthase, mitochondrial
S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase, mitochondrial
L-erythro-4-hydroxyglutamate peroxisomal transport via diffusion
putrescine transport in via proton antiport
pyrimidine-nucleoside phosphorylase (uracil)
Ubiquinol:ferricytochrome-c oxidoreductase
Phenylacetaldehyde transport (extracellular)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, mitochondrial
phosphoribosylaminoimidazole carboxylase
fatty-acid--CoA ligase (hexadecanoate), peroxisomal
guanosine transport in via proton symport
C-3 sterol dehydrogenase (4-methylzymosterol)
sphingoid base-phosphate phosphatase (phytosphingosine 1-phosphate), endoplasmic reticulum
acetyl-CoA C-acetyltransferase, mitochondrial
L-sorbitol dehydrogenase (L-sorbose-producing)
aldehyde dehydrogenase (acetylaldehyde, NADP), mitochondrial
O-acetylcarnintine transport into mitochondria via diffusion
L-sorbitol transport via passive diffusion
L-asparagine transport in via proton antiport (vacuolar)
2-methyl-1-butanol transport (mitochondrial)
glycine hydroxymethyltransferase,, mitochondrial
fatty-acyl-ACP synthase (n-C18:1ACP), mitochondrial
purine-nucleoside phosphorylase (Inosine)
glycero-3-phospho-1-inositol transport (extracellular to cytosol)
inositol-1,4,5-trisphosphate 3-kinase, nucleus
8-Amino-7-oxononanoate transport via proton symport
fatty-acid--CoA ligase (octanoate), peroxisomal
pyruvate dehydrogenase (dihydrolipoamide dehydrogenase)
2-phenylethanol transport, mitochondrial
4-Hydroxyphenylpyruvate:oxygen oxidoreductase
L-hydroxyproline dehydrogenase (NADP), mitochondrial
D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
N-acetyl-g-glutamyl-phosphate reductase, mitochondrial
4-aminobutanal mitochondrial transport via diffusion
L-aminoadipate-semialdehyde dehydrogenase (NADPH)
Octadecynoate (n-C18:2) transport in via uniport
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
aldehyde dehydrogenase (indole-3-acetaldehyde, NAD), mitochondrial
2-Methylbutanal transport (extracellular)
This is a reconstruction of the biochemical network of the yeast Saccharomyces cerevisiae carried out at a jamboree organized in April 2007 in the Manchester Centre for Integrative Systems Biology. It is the result of a consensus merger of two previous reconstructions. Technical notes: The compartments included here have no volume defined; there are no reliable estimates available for those volumes yet. There are no kinetic functions defined for the reactions because this model only represents the chemical structure of the network (stoichiometry). All reactions are marked reversible because all chemical reactions are reversible. The model is described in the article and available as supplementary material: A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Herrgård MJ, Swainston N et al. , Nat Biotechnol. 2008 Oct;26(10):1155-60. PMID: 18846089 , doi: 10.1038/nbt1492 Abstract: Genomic data allow the large-scale manual or semi-automated assembly of metabolic network reconstructions, which provide highly curated organism-specific knowledge bases. Although several genome-scale network reconstructions describe Saccharomyces cerevisiae metabolism, they differ in scope and content, and use different terminologies to describe the same chemical entities. This makes comparisons between them difficult and underscores the desirability of a consolidated metabolic network that collects and formalizes the 'community knowledge' of yeast metabolism. We describe how we have produced a consensus metabolic network reconstruction for S. cerevisiae. In drafting it, we placed special emphasis on referencing molecules to persistent databases or using database-independent forms, such as SMILES or InChI strings, as this permits their chemical structure to be represented unambiguously and in a manner that permits automated reasoning. The reconstruction is readily available via a publicly accessible database and in the Systems Biology Markup Language (http://www.comp-sys-bio.org/yeastnet). It can be maintained as a resource that serves as a common denominator for studying the systems biology of yeast. Similar strategies should benefit communities studying genome-scale metabolic networks of other organisms. Up to date versions can be found under http://www.comp-sys-bio.org/yeastnet/ This SBML representation of the yeast metabolic network is made available under the Creative Commons Attribution-Share Alike 3.0 Unported Licence (see www.creativecommons.org ). To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
NMN mitochondrial transport via proton symport
L-erythro-4-hydroxyglutamate mitochondrial transport via diffusion
4-Hydroxybenzoate mitochondrial transport
L-glutamine transport out via proton symport, vacuolar
N4-Acetylaminobutanal:NAD+ oxidoreductase
phosphate transport via hydroxide ion symport, mitochondrial
Squalene epoxidase, endoplasmic reticular (NADP)
nucleoside-diphosphate kinase (ATP:dTDP)
deoxycytidine transport in via proton symport
Pantothenate transport via proton symport
Hydroxybenzoate octaprenyltransferase, mitochondrial
nucleoside-diphosphate kinase (ATP:dUDP)
L-glutamate transport out via proton symport, vacuolar
all-trans-hexaprenyl diphosphate transport, mitochondrial
purine-nucleoside phosphorylase (Guanosine)
sphingolipid long chain base kinase (sphinganine)
nicotinate-nucleotide diphosphorylase (carboxylating), mitochondrial
purine-nucleoside phosphorylase (Deoxyguanosine)
3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA), peroxisomal
methionyl-tRNA synthetase, mitochondrial
3-Hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA), peroxisomal
S-Adenosyl-L-methionine transport, mitochondrial
glutamine-fructose-6-phosphate transaminase
fatty-acid--CoA ligase (n-C26:0), peroxisomal
3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA), peroxisomal
phosphoribosylglycinamide formyltransferase
trehalose vacuolar transport via proton symport
L-leucine transport in via proton antiport (vacuolar)
YBR026C, YER061C, YHR067W, YKL055C, YKL192C, YOR221C
glycine-cleavage system (lipoamide), mitochondrial
Oleoyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
phosphoribosylformylglycinamidine synthase
5-Formyltetrahydrofolate:10-Formyltetrahydrofolate isomerase
deoxyuridine transport in via proton symport
thymidine transport in via proton symport
riboflavin transport in via proton symport
guanine mitochondrial transport via diffusion
fatty-acid--CoA ligase (tetradecanoate), peroxisomal
3-hydroxyacyl-CoA dehydratase (3-hydroxyhexacosyl-CoA), peroxisomal
alcohol dehydrogenase, reverse rxn (acetaldehyde -> ethanol), mitochondrial
panthetheine 4'-phosphate mitochondrial transport
glucose 6-phosphate endoplasmic reticular transport via diffusion
saccharopine dehydrogenase (NAD, L-lysine forming)
fatty acyl-ACP synthase (n-C8:0ACP), mitochondrial, lumped reaction
ceramide-2 (C24) endoplasmic reticular transport
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, mitochondrial
glutamate nuclear transport via proton symport
purine-nucleoside phosphorylase (Adenosine)
phosphate peroxisomal transport via proton symport
glycero-3-phosphocholine transport (extracellular to cytosol)
phosphate vacuolar transport via proton symport
adenosine transport in via proton symport
ethanol transport to mitochondria (diffusion)
3-hydroxyacyl-CoA dehydrogenase (3-oxohexacosyl-CoA), peroxisomal
aldehyde dehydrogenase (isoamyl alcohol, NAD), mitochondrial
aspartate nuclear transport via proton symport
5-Aminolevulinate mitochondrial transport
aldehyde dehydrogenase (acetaldehyde, NADP)
trans-pentaprenyltranstransferase, mitochondrial
sulfite transport (efflux, cytosol to extracellular)
acetyl-CoA acyltransferase (tetracosanoyl-CoA), peroxisomal