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name: Bidkhori2012 - EGFR signalling in NSCLC
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notes: Bidkhori2012 - EGFR signalling in NSCLC The paper describes and compares two models on EGFR signalling between normal and NSCLC cells. Moreover, it is shown that ERK (MAPK), STAT and Akt factor's activation pattern are different between normal and NSCLA models. This model corresponds to EGFR signalling in NSCLA cells. Created by The MathWorks, Inc. SimBiology tool, Version 3.3 This model is described in the article: Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression. Bidkhori G, Moeini A, Masoudi-Nejad A PloS one [2012, 7(10):e48004] Abstract: EGFR signaling plays a very important role in NSCLC. It activates Ras/ERK, PI3K/Akt and STAT activation pathways. These are the main pathways for cell proliferation and survival. We have developed two mathematical models to relate to the different EGFR signaling in NSCLC and normal cells in the presence or absence of EGFR and PTEN mutations. The dynamics of downstream signaling pathways vary in the disease state and activation of some factors can be indicative of drug resistance. Our simulation denotes the effect of EGFR mutations and increased expression of certain factors in NSCLC EGFR signaling on each of the three pathways where levels of pERK, pSTAT and pAkt are increased. Over activation of ERK, Akt and STAT3 which are the main cell proliferation and survival factors act as promoting factors for tumor progression in NSCLC. In case of loss of PTEN, Akt activity level is considerably increased. Our simulation results show that in the presence of erlotinib, downstream factors i.e. pAkt, pSTAT3 and pERK are inhibited. However, in case of loss of PTEN expression in the presence of erlotinib, pAkt level would not decrease which demonstrates that these cells are resistant to erlotinib. This model is hosted on BioModels Database and identified by: MODEL1304020001 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published q…
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name: k1r

http://identifiers.org/biomodels.db/BIOMD0000000453#b81060d4_4f19_4cbe_ba83_624a7c0c0662
type: LocalParameter
value: 100.0
name: k1

http://identifiers.org/biomodels.db/BIOMD0000000453#_26072923_59ba_4f6e_b948_6a4dfdba00cd
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000453#bf756005_9e59_4977_a9aa_654abedad1a8
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: EGF-EGFR

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type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000453#fdbbffc5_1ee4_45f3_907a_8e1cc10e271e
type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000453#e4011b6d_d500_42ae_9c8e_bac2a0e31a4c
type: Reaction
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name: r59
reversible: true

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http://identifiers.org/biomodels.db/BIOMD0000000453#_7cc690cb_4296_4362_a545_9a9c215900fb
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stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000453#f8b25bf4_83c5_4901_8ffb_a9607587fbc4
type: LocalParameter
value: 0.8
name: kr59

http://identifiers.org/biomodels.db/BIOMD0000000453#_28d297b4_732a_4c17_9d26_edb30e8b36a4
type: LocalParameter
value: 14.3
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http://identifiers.org/biomodels.db/BIOMD0000000453#f153f96d_5a1a_4e57_bc25_64a426257556
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000453#_104f4da2_a033_4957_9a52_dddd68cf3fdc
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reversible: false
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type: LocalParameter
value: 0.003
name: k110

http://identifiers.org/biomodels.db/BIOMD0000000453#_6c37e526_e639_44ba_a98a_c989231b1c92
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http://identifiers.org/biomodels.db/BIOMD0000000453#d105831b_3df9_4150_815c_ed0c6880d6c3
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http://identifiers.org/biomodels.db/BIOMD0000000453#b5c90b5a_0f2e_4218_ac10_b103f5c57193
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http://identifiers.org/biomodels.db/BIOMD0000000453#_1640b1a7_1549_4e9d_9b0f_e8f5f1376968
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reversible: true
fast: false
name: r100

http://identifiers.org/biomodels.db/BIOMD0000000453#_76f0c813_48ab_4d43_9ce7_92d881ae1e51
type: LocalParameter
value: 0.001
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type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#_6abc934e_a5b9_4942_8d1f_8f9607506722
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http://identifiers.org/biomodels.db/BIOMD0000000453#_800f7947_c05e_4493_b96e_777850e0eff6
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reversible: false
name: r64

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type: LocalParameter
value: 0.27
name: k64

http://identifiers.org/biomodels.db/BIOMD0000000453#_01855d28_7016_425d_8dfe_ca434a3f6a5c
type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000453#d0321def_22e4_456e_b9d2_709d3adc0458
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fast: false
name: r53

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type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000453#_13908c48_f31c_402f_83c4_a4d875d029c8
type: LocalParameter
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name: kr53

http://identifiers.org/biomodels.db/BIOMD0000000453#_67eef19c_1507_4cde_b18e_d18bf1e7147c
type: LocalParameter
value: 3.0
name: k53

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type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000453#_39c0a6d3_d936_44e2_b44f_3a7982a2d725
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http://identifiers.org/biomodels.db/BIOMD0000000453#_78d14753_7ff3_4ca1_9881_00e7e9e4dc26
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http://identifiers.org/biomodels.db/BIOMD0000000453#_3453a8cc_be74_4bdc_85fd_94a24dc97af0
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http://identifiers.org/biomodels.db/BIOMD0000000453#_36beb66e_d93b_4877_a10c_62ee7814b0f3
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value: 0.02
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http://identifiers.org/biomodels.db/BIOMD0000000453#b3743f5b_be50_404e_824d_85c14af9c340
type: LocalParameter
value: 10.0
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http://identifiers.org/biomodels.db/BIOMD0000000453#_4ffe0f37_ff7b_446a_86ab_6531a77c369e
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http://identifiers.org/biomodels.db/BIOMD0000000453#_038a7ea7_b6ca_410f_973e_1c91cdb51be4
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http://identifiers.org/biomodels.db/BIOMD0000000453#_8b96100c_9d0f_4fa5_a3bd_d3e3edd5749f
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reversible: false
name: r115

http://identifiers.org/biomodels.db/BIOMD0000000453#_3a4dda0f_eb85_4d24_b40c_9c035dba4604
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http://identifiers.org/biomodels.db/BIOMD0000000453#_648442e7_573e_4d05_9d51_db78182d873b
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http://identifiers.org/biomodels.db/BIOMD0000000453#_13543bf0_5375_482c_b0ad_49efc8674a7a
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http://identifiers.org/biomodels.db/BIOMD0000000453#c43e6531_c43f_4028_86b4_e952f41dcdc0
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http://identifiers.org/biomodels.db/BIOMD0000000453#d10b6cc3_d897_4f92_8fa7_d40febc9df16
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type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#_469d6009_1207_4b39_8772_17ee50ab23a5
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http://identifiers.org/biomodels.db/BIOMD0000000453#fbab6121_eed8_47d5_a27b_2093d4ef7bcc
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http://identifiers.org/biomodels.db/BIOMD0000000453#a688eddb_34a1_4af8_a22d_dc7611de76d3
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http://identifiers.org/biomodels.db/BIOMD0000000453#_60977d4a_d87c_461b_b216_8cbc8eed0912
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http://identifiers.org/biomodels.db/BIOMD0000000453#_7ccee234_09b4_4588_8407_3667f42a8128
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http://identifiers.org/biomodels.db/BIOMD0000000453#_3439e682_0e4f_417a_a899_fc917f5dd7a6
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http://identifiers.org/biomodels.db/BIOMD0000000453#d0bd514c_02fc_4f33_a8ef_5a7dce2c6bfa
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http://identifiers.org/biomodels.db/BIOMD0000000453#_5c33eb85_3126_4644_8a14_36963bd9384f
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reversible: false

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http://identifiers.org/biomodels.db/BIOMD0000000453#c5e9d591_82b4_400b_81d8_e0c375adacc7
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type: LocalParameter
value: 0.2
name: Km

http://identifiers.org/biomodels.db/BIOMD0000000453#_6c3bc6f9_897d_4335_949d_5334f404bb05
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#_98aacbfc_2eb7_40ea_88e0_38787bc67c06
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http://identifiers.org/biomodels.db/BIOMD0000000453#ac8708ea_2726_4a50_bb8d_106f767f0fca
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http://identifiers.org/biomodels.db/BIOMD0000000453#a5748b98_7719_4912_abb4_d1a471d53318
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http://identifiers.org/biomodels.db/BIOMD0000000453#_5680390b_e10f_4ab2_a0b2_96bf230cecbd
type: LocalParameter
value: 0.005
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http://identifiers.org/biomodels.db/BIOMD0000000453#a3f099a1_ce67_420e_83c0_a24a1e0078b9
type: LocalParameter
value: 0.2
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http://identifiers.org/biomodels.db/BIOMD0000000453#de635eb8_3174_4813_8ff8_ab91bc0b59c3
type: Reaction
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http://identifiers.org/biomodels.db/BIOMD0000000453#_2a9db5ef_0df7_4201_9620_33c89f5744eb
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http://identifiers.org/biomodels.db/BIOMD0000000453#b3472d2d_ff7d_4a50_9c6c_91d326abc639
type: LocalParameter
value: 5.0E-4
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http://identifiers.org/biomodels.db/BIOMD0000000453#_2d158be9_d5e4_493b_82ca_b3613167a60b
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http://identifiers.org/biomodels.db/BIOMD0000000453#ca8eb894_84b1_4cdf_ae51_ece77716dbfb
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http://identifiers.org/biomodels.db/BIOMD0000000453#bf7df332_7c3e_46d4_ac05_cc0e90064baf
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http://identifiers.org/biomodels.db/BIOMD0000000453#ed9dbef4_5c1c_464e_9452_03e073f0203c
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http://identifiers.org/biomodels.db/BIOMD0000000453#_92c7269d_da95_42e5_886d_666ad41a81c3
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#_68c8e1fb_9608_46d1_a62b_506fc9d34ed0
type: LocalParameter
value: 14.0
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http://identifiers.org/biomodels.db/BIOMD0000000453#a4bc3f5c_0d90_4e09_989f_7d3e8e181ac7
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http://identifiers.org/biomodels.db/BIOMD0000000453#_6bab1aa5_cc3a_4c10_bb45_daeabe32b183
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http://identifiers.org/biomodels.db/BIOMD0000000453#_2be88311_8a96_4ab9_a738_3c9dc0d25f9e
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http://identifiers.org/biomodels.db/BIOMD0000000453#f94344a6_fa62_4cfe_8899_87b8f0114d32
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http://identifiers.org/biomodels.db/BIOMD0000000453#e4cd0dc2_f99b_4963_8d91_d1a1a8172ed7
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http://identifiers.org/biomodels.db/BIOMD0000000453#_017bfc82_6bff_4dbd_a705_e13337c95e39
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#fe8e72d5_b6ff_4ea5_894f_1adcb62fe138
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#dbb372ff_743f_443a_97d0_b0c9595a482a
type: Reaction
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reversible: false
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http://identifiers.org/biomodels.db/BIOMD0000000453#f7604c81_901b_4937_8a67_1a5779459e40
type: LocalParameter
value: 16.0
name: k54

http://identifiers.org/biomodels.db/BIOMD0000000453#_2e499b85_8eed_49e5_ae1e_b8b088fc8ece
type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000453#_86c12c58_2439_4536_8629_6b6a8c633646
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http://identifiers.org/biomodels.db/BIOMD0000000453#c79a8e7f_cdc9_4c77_b841_101805d5148d
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http://identifiers.org/biomodels.db/BIOMD0000000453#_775a9772_1219_43b6_9b67_bb8e0c3acd7c
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type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000453#_3563561e_ae7d_4b5e_9b11_ded599fc2b5c
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#df8c65c0_ce5a_4abd_b7bb_0da25c7118c6
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#b4df6a6e_3e17_48ec_96fc_7e20de33bfc0
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http://identifiers.org/biomodels.db/BIOMD0000000453#_8dac0907_9970_4bc8_a1d7_766002572380
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http://identifiers.org/biomodels.db/BIOMD0000000453#d93c0685_c08c_4720_a846_7b7f52ac33c4
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#e816ec9a_6792_49d7_9953_b58f94ff78e0
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#_1a254dbc_7208_43f9_8c66_8e1cb010f073
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http://identifiers.org/biomodels.db/BIOMD0000000453#_769d404b_4020_489b_b33f_927f5b089cc3
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http://identifiers.org/biomodels.db/BIOMD0000000453#_66da8cd8_8566_43ce_8a47_88b1c0352931
type: LocalParameter
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http://identifiers.org/biomodels.db/BIOMD0000000453#f69d3aa5_4864_4be3_82b8_3764198ef724
type: LocalParameter
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