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name: Bidkhori2012 - normal EGFR signalling
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notes: Bidkhori2012 - normal EGFR signalling The paper describes and compares two models on EGFR signalling between normal and NSCLC cells. Moreover, it is shown that ERK (MAPK), STAT and Akt factor's activation pattern are different between normal and NSCLA models. This model corresponds to EGFR signalling in normal cells. Created by The MathWorks, Inc. SimBiology tool, Version 3.3 This model is described in the article: Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression. Bidkhori G, Moeini A, Masoudi-Nejad A PloS one [2012, 7(10):e48004] Abstract: EGFR signaling plays a very important role in NSCLC. It activates Ras/ERK, PI3K/Akt and STAT activation pathways. These are the main pathways for cell proliferation and survival. We have developed two mathematical models to relate to the different EGFR signaling in NSCLC and normal cells in the presence or absence of EGFR and PTEN mutations. The dynamics of downstream signaling pathways vary in the disease state and activation of some factors can be indicative of drug resistance. Our simulation denotes the effect of EGFR mutations and increased expression of certain factors in NSCLC EGFR signaling on each of the three pathways where levels of pERK, pSTAT and pAkt are increased. Over activation of ERK, Akt and STAT3 which are the main cell proliferation and survival factors act as promoting factors for tumor progression in NSCLC. In case of loss of PTEN, Akt activity level is considerably increased. Our simulation results show that in the presence of erlotinib, downstream factors i.e. pAkt, pSTAT3 and pERK are inhibited. However, in case of loss of PTEN expression in the presence of erlotinib, pAkt level would not decrease which demonstrates that these cells are resistant to erlotinib. This model is hosted on BioModels Database and identified by: MODEL1304020000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published qu…
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type: LocalParameter
value: 4.481
name: k10

http://identifiers.org/biomodels.db/BIOMD0000000452#_7541c8cc_8ec0_486b_b584_450ab55d61ee
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_9266c016_c8f5_4d13_886e_966bdbf1f1c3
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#c26e65b8_1437_408e_9953_fe5e8e7c28fb
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#f4a84280_846b_447c_b1ab_dd2314a3ef8a
type: Reaction
reversible: true
fast: false
name: r42

http://identifiers.org/biomodels.db/BIOMD0000000452#_01a89ba2_acc8_4c24_ae6e_3c863425d7e1
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_224c99bf_8c11_476d_abbc_fdf28445a410
type: LocalParameter
value: 0.01
name: kr42

http://identifiers.org/biomodels.db/BIOMD0000000452#_1207561a_e477_4317_8f32_c2ee9916ae1d
type: LocalParameter
value: 0.1
name: k42

http://identifiers.org/biomodels.db/BIOMD0000000452#_43cf597d_9d30_4f13_85b1_f3c026979684
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_3de8cf4d_85ab_44ed_b2d7_1b7a38d432e5
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_38e17490_69a3_471f_b66e_7138a91f7f91
type: Reaction
fast: false
name: r84
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000452#_99ca19c8_5968_4b99_b0ea_944292d69b0f
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#b574a991_d366_494f_b803_03b5698f9023
type: SpeciesReference
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http://identifiers.org/biomodels.db/BIOMD0000000452#_0f8b81c0_dd77_407a_95c7_6a4776b31ae4
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#ef75d85a_ad24_41a0_bd68_566288baf6b3
type: LocalParameter
value: 0.1764
name: kr84

http://identifiers.org/biomodels.db/BIOMD0000000452#_9412776a_27a5_4915_95d7_2c0bddb4530b
type: LocalParameter
value: 0.09
name: k84

http://identifiers.org/biomodels.db/BIOMD0000000452#_8fabeb03_cb10_4870_8ef2_a4336178595a
type: Reaction
fast: false
reversible: false
name: r72

http://identifiers.org/biomodels.db/BIOMD0000000452#_9bcae6d0_c1d9_481b_995d_2efea2ef4276
type: LocalParameter
value: 0.005
name: k72

http://identifiers.org/biomodels.db/BIOMD0000000452#_15130088_2ca4_4281_b87c_c2b33af0b95c
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_594c6cd0_ae1e_4419_a934_c97ad54460c8
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#e357f602_fbdd_4c70_b1eb_76d20c5a18e9
type: Reaction
reversible: true
fast: false
name: r73

http://identifiers.org/biomodels.db/BIOMD0000000452#d32c4978_9b07_4b55_88a9_d4b2c5783a51
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#c8bdf03d_a6ea_4a41_8952_4397f96ec5f2
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#e955a418_3bad_4111_ad30_f75dbcee65a3
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#d94955c9_2f9a_4e73_8a08_5ca7626aba3f
type: LocalParameter
value: 0.005
name: k73r

http://identifiers.org/biomodels.db/BIOMD0000000452#_0d56efdf_fc1d_4212_9063_a75c79fa38b6
type: LocalParameter
value: 0.5
name: k73

http://identifiers.org/biomodels.db/BIOMD0000000452#f8d95f69_0c3e_419c_b5d6_6f581326e07f
type: Reaction
fast: false
reversible: true
name: r87

http://identifiers.org/biomodels.db/BIOMD0000000452#_18a7941b_3f11_42fb_a61e_270c7018ae42
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_7c04104b_666b_476d_b41f_c1046e244211
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_3c0a718e_7893_420f_8ce1_79e34d71fa92
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#f936bd42_5ea5_4185_af43_b9734618de07
type: LocalParameter
value: 2.297E-6
name: kr87

http://identifiers.org/biomodels.db/BIOMD0000000452#b4a80a1a_2f4c_4cbc_9ded_e195b523c812
type: LocalParameter
value: 4.7E-6
name: k87

http://identifiers.org/biomodels.db/BIOMD0000000452#_1321c844_c2bc_40cb_97a4_f8c2a5198466
type: Reaction
fast: false
reversible: false
name: r54

http://identifiers.org/biomodels.db/BIOMD0000000452#_6922093b_26df_437a_91da_5c99b29b03ae
type: LocalParameter
value: 16.0
name: k54

http://identifiers.org/biomodels.db/BIOMD0000000452#_013d6708_310c_4f83_b28e_084ba0eeaa50
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_40c0235a_8bee_4755_94ff_56a4878effee
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#b88ab71d_15d2_4fae_8c0c_241e8b5b917d
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#ee06b97c_074d_4ec9_948a_9ea400ca25c7
type: Reaction
fast: false
reversible: false
name: r38

http://identifiers.org/biomodels.db/BIOMD0000000452#e2a9c356_1f16_470a_ad26_dd0a4dac3d8c
type: LocalParameter
value: 0.1434
name: k38

http://identifiers.org/biomodels.db/BIOMD0000000452#d05ba59d_7763_4af6_bb0f_367aad49e971
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_6a0a7959_b86d_4e21_820a_9e724a2122b9
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#c6e9a352_7d01_4fba_9dac_fe33e3d08cf5
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#f38e693e_ac77_4646_8d16_d9de6bb2557a
type: Reaction
fast: false
reversible: false
name: 113

http://identifiers.org/biomodels.db/BIOMD0000000452#_637e8b39_7a92_426d_b53c_adf2b6242cd6
type: LocalParameter
value: 0.003
name: k113

http://identifiers.org/biomodels.db/BIOMD0000000452#c2fbec96_accd_4a0d_b562_439ef9ec7320
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_3b201551_b26a_4569_b5b1_5139d7c97271
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#fdcc5ef6_5dd2_4f95_bbed_ec23c23be552
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_8b452785_a17b_4786_a62a_664de4a1f003
type: Reaction
name: 114
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000452#_4fe80528_28ac_4797_815e_4df507d019c6
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#e0ae84d7_df6a_4f33_be96_9c7e205b03cb
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000452#_6ba28256_e38f_4b49_b1b9_2cadf6d360f2
type: LocalParameter
value: 0.2
name: k114r

http://identifiers.org/biomodels.db/BIOMD0000000452#f6d68174_c534_4ee1_a8f6_97ad5812f8f6
type: LocalParameter
value: 2.0E-4
name: k114

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type: SpeciesReference
stoichiometry: 1.0