BIOMD0000000450
type: SBMLModel
reaction: COPASI103
species: COPASI45
reaction: COPASI146
name: function_4_VcSHMT_1
name: function_4_V_DMGD_1
species: COPASI37
name: function_4_V_PGT_1
name: function_4_V_DNMT_1
name: function_4_VcMTCH_1
is: MODEL1305060001
species: COPASI28
species: COPASI33
name: function_4_V_c_gsgHb_1
parameter: COPASI79
species: COPASI50
reaction: COPASI97
reaction: COPASI91
name: function_4_V_SAHH_1
reaction: COPASI95
name: function_4_VmFTS_1
reaction: COPASI124
reaction: COPASI136
name: function_4_V_b_SER_c_1
volume units: metaid_0000007
species: COPASI16
name: function_4_c_gsg_degr_1
reaction: COPASI122
reaction: COPASI134
name: function_4_V_ODC_1
reaction: COPASI141
species: COPASI27
parameter: COPASI80
species: COPASI9
reaction: COPASI137
reaction: COPASI135
area units: area
parameter: COPASI74
name: function_4_VmFTD_1
name: function_4_b_cys_loss_1
name: function_4_VcMTD_1
name: function_4_V_MATII
parameter: COPASI81
name: function_4_V_PAO_AD_1
species: COPASI52
name: function_4_VmSERc_1
name: function_4_c_gsh_degr_1
name: function_4_VcNE_1
reaction: COPASI100
reaction: COPASI112
reaction: COPASI147
name: function_4_V_b_CYS_c_1
parameter: COPASI86
species: COPASI8
parameter: COPASI62
species: COPASI24
reaction: COPASI110
species: COPASI20
reaction: COPASI113
parameter: COPASI87
name: function_4_V_GR_1
name: function_4_V_b_GLY_c_1
parameter: COPASI63
reaction: COPASI111
name: MM
parameter: COPASI76
species: COPASI12
species: COPASI39
reaction: COPASI108
species: COPASI19
reaction: COPASI92
species: COPASI56
reaction: COPASI106
name: Constant flux (reversible)
reaction: COPASI118
name: function_4_V_GNMT_1
reaction: COPASI125
compartment: COPASI5
species: COPASI48
reaction: COPASI123

http://identifiers.org/biomodels.db/BIOMD0000000450#_0ddf89c3_605c_4728_8664_e38f4cadae99
type: Parameter
constant: true
value: 150.0
name: V_gshHb

COPASI103
type: Reaction
is version of: GO:0042883
name: V_b_CYS_c
reversible: true
fast: false

COPASI10
type: Species
initial concentration: 183.099466381356
name: b_Cysteine
in compartment: COPASI2
is version of: CHEBI:15356
constant: false
boundary condition: false
initial amount: NaN
is version of: C00736
has only substance units: false

COPASI2
type: Compartment
is version of: BTO:0000089
constant: true
size: 1.0
spatial dimensions: 3.0
name: blood

http://identifiers.org/biomodels.db/BIOMD0000000450#faf93253_a7d9_463a_91e5_7a852615c8fb
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

http://identifiers.org/biomodels.db/BIOMD0000000450#_66cbc728_2924_4a55_ae89_8852dc04c676
type: SpeciesReference
stoichiometry: 1.0
species: COPASI26

COPASI26
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 179.792196767939
is version of: CHEBI:15356
name: c_Cysteine
in compartment: COPASI3
is version of: C00736

COPASI3
type: Compartment
is version of: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol

COPASI45
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 38.833390762794
initial amount: NaN
in compartment: COPASI3
name: Acetyl-CoA

COPASI146
type: Reaction
fast: false
reversible: false
name: V_PUT_efflux

http://identifiers.org/biomodels.db/BIOMD0000000450#ffb770b5_f2ea_49a8_a23a_a74919c51a80
type: LocalParameter
value: 0.6
name: k1

COPASI39
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 98.2036296721139
initial amount: NaN
in compartment: COPASI3
name: Putrescine

http://identifiers.org/biomodels.db/BIOMD0000000450#_3d2ae1c4_8268_4557_a750_73a8ce268f87
type: SpeciesReference
stoichiometry: 1.0
species: COPASI39

http://identifiers.org/biomodels.db/BIOMD0000000450#_699bdbf4_3126_41ad_9c2d_c35c483e6174
type: Parameter
constant: true
value: 180000.0
name: Vf_mMTD

http://identifiers.org/biomodels.db/BIOMD0000000450#_5fdcfde7_2312_4096_a0bd_928446502cee
type: Parameter
constant: false
value: 630.0
name: V_oGly_b

http://identifiers.org/biomodels.db/BIOMD0000000450#_38f9cc13_5f95_42e9_a8a7_40bee764c709
type: Parameter
constant: true
value: 150.0
name: b_ser_basal

http://identifiers.org/biomodels.db/BIOMD0000000450#_993b69d7_360d_4a86_b389_2d1743c16356
type: Parameter
constant: true
value: 1.0
name: k_out_ser

http://identifiers.org/biomodels.db/BIOMD0000000450#_635e01f1_8589_49c3_99a0_212e9e34c6eb
type: Parameter
constant: true
value: 892.5
name: Vm_GR

http://identifiers.org/biomodels.db/BIOMD0000000450#e0dc5250_365b_44dc_80c7_254b286f43ea
type: Parameter
constant: true
value: 3000.0
name: K_gshLb

COPASI37
type: Species
constant: false
initial concentration: 13.9758110645557
name: c_Formate
has only substance units: false
in compartment: COPASI3
boundary condition: false
is version of: CHEBI:15740
is version of: C00058
initial amount: NaN

http://identifiers.org/biomodels.db/BIOMD0000000450#_18100bda_cb51_4976_8614_b194be32fb75
type: Parameter
constant: true
value: 320.0
name: Vf_SAHH

http://identifiers.org/biomodels.db/BIOMD0000000450#_7c80759a_9d85_4e03_a90b_0dc394408208
type: Parameter
constant: true
value: 1.0
name: k_out_cys

http://identifiers.org/biomodels.db/BIOMD0000000450#_35d39164_3ec0_4f35_ac0f_92474da1c3cc
type: Parameter
constant: true
value: 0.03
name: k1_mNE

COPASI28
type: Species
initial amount: NaN
is version of: CHEBI:15428
initial concentration: 927.56013101536
name: c_Glycine
constant: false
is version of: C00037
has only substance units: false
in compartment: COPASI3
boundary condition: false

COPASI33
type: Species
boundary condition: false
name: c_Serine
constant: false
has only substance units: false
is version of: C00716
initial concentration: 571.225285800751
initial amount: NaN
is version of: CHEBI:17822
in compartment: COPASI3

http://identifiers.org/biomodels.db/BIOMD0000000450#_764dfa66_d470_47f4_b640_e70ffd898d82
type: Parameter
constant: true
value: 40.0
name: V_gsgHb

http://identifiers.org/biomodels.db/BIOMD0000000450#ab7f76c9_e566_4e7f_96d7_c8dbab3fa1e6
type: Parameter
constant: true
value: 180.0
name: Vm_DNMT

http://identifiers.org/biomodels.db/BIOMD0000000450#_7d400541_34c3_435f_a1fe_b9b658142252
type: Parameter
constant: true
value: 300.0
name: K_bglutc

http://identifiers.org/biomodels.db/BIOMD0000000450#fafd0de4_2b71_4f96_bb09_99558e95881d
type: Parameter
constant: true
value: 5700.0
name: K_cser

COPASI79
type: Parameter
constant: true
value: 60.0
name: Ks_SAMDC

COPASI50
type: Species
is version of: http://identifiers.org/pubchem.compound/644350
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.55022131198345
initial amount: NaN
in compartment: COPASI4
name: m_5-10-methenyl-THF

COPASI4
type: Compartment
is version of: GO:0005739
constant: true
size: 1.0
spatial dimensions: 3.0
name: mitochondrion

COPASI97
type: Reaction
is version of: GO:0015816
fast: false
reversible: true
name: b_gly_import

http://identifiers.org/biomodels.db/BIOMD0000000450#_8a768215_ccc2_4e56_9017_c030b7bf4a44
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI8
type: Species
has only substance units: false
is version of: CHEBI:15428
name: b_Glycine
initial amount: NaN
in compartment: COPASI2
initial concentration: 218.733171504338
boundary condition: false
constant: false
is version of: C00037

http://identifiers.org/biomodels.db/BIOMD0000000450#b40777b2_f788_49dc_8922_52b3acc9618b
type: Parameter
constant: true
value: 107.0
name: K_gsg_GR

http://identifiers.org/biomodels.db/BIOMD0000000450#_975070d7_b5ea_4fad_85f7_e72a1c7a5476
type: Parameter
constant: true
value: 100.0
name: K_cys_GCS

COPASI91
type: Reaction
is version of: GO:0009093
fast: false
reversible: true
name: b_cys_loss

http://identifiers.org/biomodels.db/BIOMD0000000450#_88419b97_10e2_440e_b344_740d36a07382
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

http://identifiers.org/biomodels.db/BIOMD0000000450#_4dc4a408_9a73_40b9_93b8_85b1eaaeb477
type: Parameter
constant: true
value: 3.0
name: h_gshLb

COPASI95
type: Reaction
is version of: GO:0006751
fast: false
reversible: true
name: b_gsg_loss

COPASI11
type: Species
is version of: C00127
in compartment: COPASI2
constant: false
name: b_GSSG
initial amount: NaN
initial concentration: 0.472632922783833
has only substance units: false
is version of: CHEBI:17858
boundary condition: false

http://identifiers.org/biomodels.db/BIOMD0000000450#f0c911d9_0733_4ef2_9171_abac5e6856fd
type: SpeciesReference
stoichiometry: 1.0
species: COPASI11

http://identifiers.org/biomodels.db/BIOMD0000000450#a8a561af_00a7_423e_be1a_595dd61654f8
type: Parameter
constant: true
value: 320.0
name: K_src_SDH

http://identifiers.org/biomodels.db/BIOMD0000000450#bac3634f_55f7_4edf_9960_80c64260e700
type: Parameter
constant: true
value: 1000.0
name: K_hcy_CBS

http://identifiers.org/biomodels.db/BIOMD0000000450#bdb5bf0c_6aaa_43cd_ba6a_a6e9186ed478
type: Parameter
constant: true
value: 43.0
name: K_coo_cFTS

COPASI124
type: Reaction
fast: false
name: V_SAHH
is version of: R00192
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#a13e08d4_ca88_4cba_b8d3_d42b97380b80
type: SpeciesReference
stoichiometry: 1.0
species: COPASI32

COPASI32
type: Species
is version of: CHEBI:17230
name: Homocysteine
in compartment: COPASI3
is version of: C05330
initial concentration: 1.02425194863179
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN

COPASI34
type: Species
name: SAH
has only substance units: false
is version of: CHEBI:16680
boundary condition: false
is version of: C00021
initial concentration: 15.5626693211634
initial amount: NaN
in compartment: COPASI3
constant: false

http://identifiers.org/biomodels.db/BIOMD0000000450#cb1eeebd_5cfc_4371_8d08_4a4f947c5a6b
type: SpeciesReference
stoichiometry: 1.0
species: COPASI34

COPASI136
type: Reaction
reversible: true
name: V_ODC
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_5c0c883d_ac2b_4d5b_9d33_dac254439ccc
type: SpeciesReference
stoichiometry: 1.0
species: COPASI44

COPASI44
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: COPASI3
name: Ornithine

http://identifiers.org/biomodels.db/BIOMD0000000450#_8ed91f5a_21d3_4cd2_a499_dfb8daea974a
type: SpeciesReference
stoichiometry: 1.0
species: COPASI39

http://identifiers.org/biomodels.db/BIOMD0000000450#_526fbfcb_b19c_482a_bf49_ed980ba3e68a
type: LocalParameter
value: 60.0
name: Kmodc

http://identifiers.org/biomodels.db/BIOMD0000000450#f76d030b_4e51_4aef_94b0_138ca11e0643
type: LocalParameter
value: 1300.0
name: Kipodc

COPASI16
type: Species
boundary condition: true
is version of: CHEBI:17622
name: dUMP
has only substance units: false
constant: true
in compartment: COPASI3
initial concentration: 20.0
is version of: C00365
initial amount: NaN

COPASI122
type: Reaction
is version of: R00367
fast: false
reversible: true
name: V_GNMT

http://identifiers.org/biomodels.db/BIOMD0000000450#f2002117_f651_45e0_8d5f_0c5be218d152
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

COPASI35
type: Species
has only substance units: false
initial concentration: 65.0613824844853
initial amount: NaN
in compartment: COPASI3
constant: false
is version of: CHEBI:15414
name: SAM
boundary condition: false
is version of: C00019

http://identifiers.org/biomodels.db/BIOMD0000000450#_3c84ec44_20bf_4ce2_9fdb_160e5e17ab96
type: SpeciesReference
stoichiometry: 1.0
species: COPASI57

COPASI57
type: Species
constant: false
boundary condition: false
initial amount: NaN
is version of: C00213
in compartment: COPASI5
is version of: CHEBI:15611
name: Sarcosine
has only substance units: false
initial concentration: 8.25411023033989

COPASI5
type: Compartment
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

http://identifiers.org/biomodels.db/BIOMD0000000450#_79eda052_6f3d_445c_9273_ac9b3b3e05dc
type: SpeciesReference
stoichiometry: 1.0
species: COPASI35

COPASI19
type: Species
name: c_5-methyl-THF
initial concentration: 5.36079859230553
is version of: CHEBI:15641
has only substance units: false
initial amount: NaN
in compartment: COPASI3
constant: false
is version of: C00440
boundary condition: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_7da91a91_9f93_4832_aacb_42d50089cadd
type: SpeciesReference
stoichiometry: 1.0
species: COPASI34

http://identifiers.org/biomodels.db/BIOMD0000000450#a726b70a_89ca_4cfa_b53b_7a2390c4798f
type: Parameter
constant: true
value: 50.0
name: K_thf_DMGD

http://identifiers.org/biomodels.db/BIOMD0000000450#_6563f8a9_de51_4b2c_9639_6ff37972ded9
type: Parameter
constant: true
value: 22.0
name: k2_cNE

COPASI134
type: Reaction
is version of: GO:0006751
fast: false
reversible: true
name: c_gsh_degr

COPASI30
type: Species
initial amount: NaN
is version of: CHEBI:16856
is version of: C00051
has only substance units: false
boundary condition: false
initial concentration: 6272.51492720171
name: c_GSH
constant: false
in compartment: COPASI3

http://identifiers.org/biomodels.db/BIOMD0000000450#c5b8ba22_56a2_443c_81cf_20b5409e71bd
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

http://identifiers.org/biomodels.db/BIOMD0000000450#_5cbbfa21_a81e_4a51_bf90_d0086d70b3f8
type: Reaction
name: V_MS
reversible: true
fast: false

COPASI17
type: Species
constant: true
has only substance units: false
name: H2O2
in compartment: COPASI3
is version of: C00027
initial amount: NaN
initial concentration: 0.015
is version of: CHEBI:16240
boundary condition: true

http://identifiers.org/biomodels.db/BIOMD0000000450#f202ac39_3814_441d_8687_bd14ac4778c1
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

http://identifiers.org/biomodels.db/BIOMD0000000450#bbd6d249_ef36_46c4_a30e_87bf4044dbda
type: SpeciesReference
stoichiometry: 1.0
species: COPASI32

http://identifiers.org/biomodels.db/BIOMD0000000450#_370e9560_ecb1_47e1_9edc_73e0eac2b3dc
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

COPASI18
type: Species
is version of: C00101
constant: false
initial concentration: 4.0250933022918
is version of: CHEBI:15635
name: c_THF
has only substance units: false
boundary condition: false
initial amount: NaN
in compartment: COPASI3

http://identifiers.org/biomodels.db/BIOMD0000000450#ae5b0f61_f27b_4336_9d18_deba2b33357a
type: SpeciesReference
stoichiometry: 1.0
species: COPASI36

COPASI36
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 50.6006924474774
has only substance units: false
in compartment: COPASI3
is: CHEBI:16811
name: c_Methionine
is: C01733

http://identifiers.org/biomodels.db/BIOMD0000000450#b1d907e5_d75d_4989_9a1e_e85b61c307af
type: Parameter
constant: true
value: 5600.0
name: Ke_GS

COPASI141
type: Reaction
name: V_PAO_AS
reversible: true
fast: false

COPASI43
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.903751442137693
initial amount: NaN
in compartment: COPASI3
name: Acetylspermidine

COPASI42
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0272742537826481
initial amount: NaN
in compartment: COPASI3
name: Acetylspermine

http://identifiers.org/biomodels.db/BIOMD0000000450#_04814c05_2ea2_411c_ab2b_6fd5c8296913
type: SpeciesReference
stoichiometry: 1.0
species: COPASI41

COPASI41
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 79.5917525310194
initial amount: NaN
in compartment: COPASI3
name: Spermidine

COPASI40
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 61.3595114874529
initial amount: NaN
in compartment: COPASI3
name: Spermine

http://identifiers.org/biomodels.db/BIOMD0000000450#c7860883_75b4_42c7_8807_1e233316fc1d
type: LocalParameter
value: 621.0
name: Vmpao

http://identifiers.org/biomodels.db/BIOMD0000000450#_64631311_aee7_42e2_9f9f_d839ab5c8cc5
type: LocalParameter
value: 15.0
name: Kmspao

http://identifiers.org/biomodels.db/BIOMD0000000450#b3f8409a_541a_45e6_9a21_8e28b6ec6843
type: LocalParameter
value: 50.0
name: Kmdpao

http://identifiers.org/biomodels.db/BIOMD0000000450#a060ff91_c3ab_4ecb_8fbe_622762b7c3a6
type: LocalParameter
value: 0.6
name: Kmaspao

http://identifiers.org/biomodels.db/BIOMD0000000450#a18f695d_521a_45a6_88d2_989a36b266bd
type: LocalParameter
value: 14.0
name: Kmadpao

http://identifiers.org/biomodels.db/BIOMD0000000450#a46a22c5_8880_4816_abb9_35fc343fa0e2
type: SpeciesReference
stoichiometry: 1.0
species: COPASI42

http://identifiers.org/biomodels.db/BIOMD0000000450#_31bd42c9_b919_4bde_b793_4d991e03ae82
type: Parameter
constant: true
value: 273.0
name: V_oGlu_b_basal

http://identifiers.org/biomodels.db/BIOMD0000000450#fa7f3119_920d_4423_8b47_5e091d835598
type: Parameter
constant: true
value: 2140.0
name: Ki_MAT1

COPASI27
type: Species
initial concentration: 9.60706615144005
name: Glutamyl-Cysteine
initial amount: NaN
boundary condition: false
is version of: C00669
constant: false
in compartment: COPASI3
has only substance units: false
is version of: CHEBI:17515

COPASI80
type: Parameter
constant: true
value: 0.02
name: Kd_ANTZ

http://identifiers.org/biomodels.db/BIOMD0000000450#_02f8f26f_6719_449e_931f_64b888b39210
type: Parameter
constant: true
value: 913.4
name: V_bmetc

http://identifiers.org/biomodels.db/BIOMD0000000450#_97970a67_cd02_4501_afc4_4198dfb426d8
type: Parameter
constant: true
value: 2100.0
name: K_bcysc

COPASI9
type: Species
boundary condition: false
has only substance units: false
initial concentration: 60.4651616225031
constant: false
is version of: C00302
is version of: CHEBI:18237
name: b_Glutamate
initial amount: NaN
in compartment: COPASI2

http://identifiers.org/biomodels.db/BIOMD0000000450#_016b59f3_18de_4d98_87a4_37d9f91195c3
type: Parameter
constant: false
value: 273.0
name: V_oGlu_b

COPASI137
type: Reaction
name: V_SAMDC
fast: false
reversible: true

COPASI38
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.011178638638793
initial amount: NaN
in compartment: COPASI3
name: dcSAM

http://identifiers.org/biomodels.db/BIOMD0000000450#d0779250_328b_44e8_b784_0b82bc5ed412
type: SpeciesReference
stoichiometry: 1.0
species: COPASI38

http://identifiers.org/biomodels.db/BIOMD0000000450#_5cbd34e7_90aa_4f59_97c0_e24498cbed2f
type: SpeciesReference
stoichiometry: 1.0
species: COPASI35

http://identifiers.org/biomodels.db/BIOMD0000000450#fa32a7ac_ce71_49c5_b19a_9ca3db066373
type: LocalParameter
value: 50.0
name: Kmsamdc

http://identifiers.org/biomodels.db/BIOMD0000000450#d0b250af_80e4_4643_b858_46ab8d9850e7
type: LocalParameter
value: 500.0
name: Kissamdc

http://identifiers.org/biomodels.db/BIOMD0000000450#c2d720d3_06bb_4846_b626_483276362f3c
type: LocalParameter
value: 2.5
name: Kiasamdc

http://identifiers.org/biomodels.db/BIOMD0000000450#a6c07bf4_484b_4ea9_8d67_37dd51da36f5
type: LocalParameter
value: 0.5
name: Kapsamdc

http://identifiers.org/biomodels.db/BIOMD0000000450#_9b6ebc4b_a4b4_4fbb_9ee9_b64ac9606a57
type: Parameter
constant: true
value: 0.5
name: K_dhf_DHFR

http://identifiers.org/biomodels.db/BIOMD0000000450#_6569a7fa_d94f_4d0c_a6c7_d48916246ad4
type: Parameter
constant: true
value: 43.0
name: K_coo_mFTS

http://identifiers.org/biomodels.db/BIOMD0000000450#_79b93084_5b2f_4dac_835a_6c7c2994f48b
type: Parameter
constant: true
value: 41.0
name: Km_MAT1

COPASI135
type: Reaction
is version of: GO:0006751
fast: false
reversible: true
name: c_gsg_degr

COPASI29
type: Species
in compartment: COPASI3
initial amount: NaN
initial concentration: 59.8062682413464
is version of: CHEBI:17858
constant: false
boundary condition: false
is version of: C00127
has only substance units: false
name: c_GSSG

http://identifiers.org/biomodels.db/BIOMD0000000450#c9f6dba2_36dd_485a_bf8f_2d9b616c7cea
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

COPASI74
type: Parameter
constant: true
value: 3.0
name: Kd_ODC

COPASI81
type: Parameter
constant: true
value: 0.02
name: Ks_ANTZ

http://identifiers.org/biomodels.db/BIOMD0000000450#c08e7c49_7aba_4534_aae2_2a575e310297
type: Parameter
constant: true
value: 22.0
name: K_glc_GS

http://identifiers.org/biomodels.db/BIOMD0000000450#_722a5eba_46a9_48b4_8ed6_c82d5ac79c76
type: Parameter
constant: true
value: 5597.0
name: Ke_GCS

http://identifiers.org/biomodels.db/BIOMD0000000450#_666bb8dd_8b31_405f_a70d_30ca597d5f10
type: Parameter
constant: true
value: 500.0
name: K_cyt_CTGL

http://identifiers.org/biomodels.db/BIOMD0000000450#_695e1484_fb01_4e31_bb86_4cd30b23d69e
type: Reaction
fast: false
reversible: true
name: VmHCOOHc

http://identifiers.org/biomodels.db/BIOMD0000000450#_966016ee_1909_453d_a345_965456c4a73f
type: SpeciesReference
stoichiometry: 3.0
species: COPASI54

COPASI54
type: Species
boundary condition: false
constant: false
is version of: C00058
has only substance units: false
initial concentration: 58.3710073680041
name: m_Formate
is version of: CHEBI:15740
in compartment: COPASI4
initial amount: NaN

http://identifiers.org/biomodels.db/BIOMD0000000450#af56f2f9_887d_4ffd_bf1e_75b8138b7eb9
type: SpeciesReference
stoichiometry: 1.0
species: COPASI37

http://identifiers.org/biomodels.db/BIOMD0000000450#_868527b8_02a7_43b1_8b6f_5ba311528358
type: Parameter
constant: true
value: 100.0
name: K_bet_BHMT

COPASI52
type: Species
name: m_Serine
has only substance units: false
constant: false
in compartment: COPASI4
is version of: CHEBI:17822
is version of: C00716
initial amount: NaN
initial concentration: 2150.05782513217
boundary condition: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_3645baae_bb1c_4aee_9816_34224530f62d
type: Reaction
fast: false
reversible: true
name: V_DHFR

COPASI23
type: Species
name: c_DHF
boundary condition: false
initial concentration: 0.0352527196984464
is version of: C00415
constant: false
in compartment: COPASI3
is version of: CHEBI:15633
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/BIOMD0000000450#c39e75c1_7c11_43e0_bee2_bb81bd9a7902
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

COPASI14
type: Species
initial amount: NaN
initial concentration: 50.0
is version of: C00005
is version of: CHEBI:16474
boundary condition: true
constant: true
name: NADPH
has only substance units: false
in compartment: COPASI3

http://identifiers.org/biomodels.db/BIOMD0000000450#_2bcc913b_01fb_4df9_9a38_52d08c98937f
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

http://identifiers.org/biomodels.db/BIOMD0000000450#b59d2e24_2b5b_4a24_9f72_c3cbd345d843
type: SpeciesReference
stoichiometry: 1.0
species: COPASI23

http://identifiers.org/biomodels.db/BIOMD0000000450#c02d9384_d574_481c_b27f_e2152baffd12
type: Parameter
constant: true
value: 63.0
name: K_sam_GNMT

http://identifiers.org/biomodels.db/BIOMD0000000450#be93effa_2a88_4171_ad1d_1427abb835a1
type: Parameter
constant: true
value: 2000.0
name: Vm_DHFR

http://identifiers.org/biomodels.db/BIOMD0000000450#c72e0c21_6e72_47e6_957f_96ee8f9a6093
type: Parameter
constant: true
value: 260.0
name: Vm_GNMT

COPASI100
type: Reaction
is version of: GO:0034635
fast: false
name: V_c_gshLb
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#_3c904235_f227_46f7_b47c_e8418f330178
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

http://identifiers.org/biomodels.db/BIOMD0000000450#_4ca4a2a4_89de_47bd_9a38_b423a342d2dc
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

COPASI12
type: Species
boundary condition: false
initial amount: NaN
constant: false
is version of: C00051
initial concentration: 12.5470655822207
is version of: CHEBI:16856
name: b_GSH
has only substance units: false
in compartment: COPASI2

COPASI112
type: Reaction
fast: false
reversible: true
name: VcFTD

COPASI22
type: Species
has only substance units: false
name: c_10-formyl-THF
in compartment: COPASI3
initial concentration: 3.25539505319571
constant: false
boundary condition: false
is version of: CHEBI:15637
initial amount: NaN
is version of: C00234

http://identifiers.org/biomodels.db/BIOMD0000000450#_98e1f2a6_8c3d_4c84_abde_7ad452b6c893
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

http://identifiers.org/biomodels.db/BIOMD0000000450#_4591c563_9b42_4bd7_91fc_dd4eca429ab5
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

COPASI147
type: Reaction
fast: false
reversible: false
name: V_AD_efflux

http://identifiers.org/biomodels.db/BIOMD0000000450#b5e30dc3_428f_4c5e_b39c_87dd3645f453
type: LocalParameter
value: 0.6
name: k1

http://identifiers.org/biomodels.db/BIOMD0000000450#_39c215a9_b380_4809_a91f_ba345e8c06e4
type: SpeciesReference
stoichiometry: 1.0
species: COPASI43

http://identifiers.org/biomodels.db/BIOMD0000000450#_65299554_f7c9_4a67_9489_603a5860d019
type: Parameter
constant: true
value: 2000.0
name: Vf_mFTS

COPASI86
type: Parameter
constant: false
value: 100.0
name: R_percent

COPASI62
type: Parameter
constant: true
value: 1.0
name: dinner

http://identifiers.org/biomodels.db/BIOMD0000000450#c60cd67b_49b3_4304_a952_9b826bae1f6c
type: Parameter
constant: true
value: 0.03
name: k1_cNE

http://identifiers.org/biomodels.db/BIOMD0000000450#_8c68c6dc_c3c3_4ae5_a351_e59f2b6ea7e0
type: Parameter
constant: true
value: 5400.0
name: Vm_GS

COPASI24
type: Species
initial concentration: 0.944676738309717
boundary condition: false
initial amount: NaN
constant: false
is version of: CHEBI:18406
in compartment: COPASI3
has only substance units: false
is version of: C04677
name: AICAR

http://identifiers.org/biomodels.db/BIOMD0000000450#_13998e7a_1b4c_44c5_9c3f_7a84bf0c1fc2
type: Parameter
constant: true
value: 15000.0
name: Vm_SDH

COPASI110
type: Reaction
name: VmFTS
reversible: true
fast: false
is version of: R00944

COPASI48
type: Species
initial amount: NaN
is version of: CHEBI:15635
constant: false
boundary condition: false
initial concentration: 20.989363966111
is version of: C00101
name: m_THF
has only substance units: false
in compartment: COPASI4

http://identifiers.org/biomodels.db/BIOMD0000000450#_408bb095_b61f_45b8_bc52_6e15dfd00d6c
type: SpeciesReference
stoichiometry: 1.0
species: COPASI54

http://identifiers.org/biomodels.db/BIOMD0000000450#_2a382a8b_b35d_483c_96d7_5d0214a59f28
type: SpeciesReference
stoichiometry: 1.0
species: COPASI51

COPASI51
type: Species
constant: false
initial concentration: 15.9931179032642
in compartment: COPASI4
has only substance units: false
name: m_10-formyl-THF
initial amount: NaN
is version of: C00234
is version of: CHEBI:15637
boundary condition: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_5ad2c827_fa48_4440_8a68_ca0c9f3405e2
type: SpeciesReference
stoichiometry: 1.0
species: COPASI48

http://identifiers.org/biomodels.db/BIOMD0000000450#adc4f333_ffc1_4f4f_b53f_5f56a4567b79
type: Parameter
constant: true
value: 300.0
name: K_gly_GS

http://identifiers.org/biomodels.db/BIOMD0000000450#cbcd4018_f922_46c0_a6ac_b2b9212d783b
type: Parameter
constant: true
value: 1330.0
name: K_gsh_GPX

COPASI20
type: Species
initial amount: NaN
is version of: CHEBI:1989
is version of: C00143
in compartment: COPASI3
initial concentration: 0.463962655701761
boundary condition: false
constant: false
name: c_5-10-methylene-THF
has only substance units: false

COPASI113
type: Reaction
reversible: true
name: VcSHMT
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_488b57ef_ead1_4ce6_ba11_2d97ec924b83
type: SpeciesReference
stoichiometry: 1.0
species: COPASI33

http://identifiers.org/biomodels.db/BIOMD0000000450#bdde571a_ec84_4394_afca_5433d11e1772
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

http://identifiers.org/biomodels.db/BIOMD0000000450#_835e7c2c_f656_4daf_9e0c_1b3eba5bf374
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

http://identifiers.org/biomodels.db/BIOMD0000000450#_571e1fbb_17ab_4c20_b039_8a21eb2ea3a3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

http://identifiers.org/biomodels.db/BIOMD0000000450#_7467158e_4c62_4cff_b112_1cdac82178cd
type: Parameter
constant: true
value: 150.0
name: K_bserc

COPASI87
type: Parameter
constant: true
value: 220.0
name: Vm_MATII

COPASI63
type: Parameter
constant: true
value: 1.0
name: lunch

COPASI111
type: Reaction
is version of: R09093
reversible: true
fast: false
name: VmNE

http://identifiers.org/biomodels.db/BIOMD0000000450#ec7bb5a5_9845_4504_bed4_63204a66edec
type: SpeciesReference
stoichiometry: 1.0
species: COPASI56

COPASI56
type: Species
has only substance units: false
in compartment: COPASI5
constant: true
initial concentration: 500.0
initial amount: NaN
is version of: CHEBI:16842
name: Formaldehyde
boundary condition: true
is version of: C00067

http://identifiers.org/biomodels.db/BIOMD0000000450#_892ad601_75c0_4331_97cc_070ea67b8f0e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI49

COPASI49
type: Species
is version of: CHEBI:1989
is version of: C00143
in compartment: COPASI4
name: m_5-10-methylene-THF
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.66729681864136
constant: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_824bde67_cc6c_41f3_8a0e_7cb5ec0b3841
type: SpeciesReference
stoichiometry: 1.0
species: COPASI48

http://identifiers.org/biomodels.db/BIOMD0000000450#ae1ec68b_d210_47cb_8dbc_5f8f48a5d2b8
type: Parameter
constant: true
value: 630.0
name: V_oGly_b_basal

http://identifiers.org/biomodels.db/BIOMD0000000450#_8cea5c5b_d8a4_4f30_bc19_6ff92dace796
type: Parameter
constant: true
value: 150.0
name: K_hcy_SAHH

http://identifiers.org/biomodels.db/BIOMD0000000450#_5aa391e2_f19a_4dda_9a60_8104cb0219e8
type: Parameter
constant: true
value: 5000.0
name: Vm_TS

COPASI76
type: Parameter
constant: true
value: 12.0
name: Kd_SSAT

http://identifiers.org/biomodels.db/BIOMD0000000450#_07b43327_a6ae_46a0_8c29_f9dc58da1972
type: Parameter
constant: true
value: 10000.0
name: V_mser

http://identifiers.org/biomodels.db/BIOMD0000000450#d4444f52_ad93_4f8d_95b2_bd0b626f65d2
type: Parameter
constant: true
value: 28000.0
name: V_bglutc

COPASI108
type: Reaction
reversible: true
fast: false
is version of: R00941
name: VmFTD

http://identifiers.org/biomodels.db/BIOMD0000000450#d1510c2b_0e6a_416d_88db_3e4ea2fa0c5b
type: SpeciesReference
stoichiometry: 1.0
species: COPASI48

http://identifiers.org/biomodels.db/BIOMD0000000450#dd06a8eb_2425_4dbe_b354_ef6997d0ce76
type: SpeciesReference
stoichiometry: 1.0
species: COPASI51

http://identifiers.org/biomodels.db/BIOMD0000000450#f95fc3a6_cc95_4219_9256_02ca03cabb70
type: Parameter
constant: true
value: 4500.0
name: Vm_GPX

COPASI92
type: Reaction
is version of: GO:0006538
fast: false
reversible: true
name: b_glu_loss

http://identifiers.org/biomodels.db/BIOMD0000000450#dc62aa46_751b_4a16_b149_4582421443d7
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

http://identifiers.org/biomodels.db/BIOMD0000000450#_3902e8fd_f1a7_40d3_8cc9_09ae7fd51f48
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

COPASI106
type: Reaction
is version of: GO:0032329
name: V_b_SER_c
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_42fc34f2_5209_4298_87a5_20ce0355990b
type: SpeciesReference
stoichiometry: 1.0
species: COPASI33

COPASI7
type: Species
initial concentration: 150.0
has only substance units: false
name: b_Serine
initial amount: NaN
in compartment: COPASI2
is version of: CHEBI:17822
is version of: C00716
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_6defc669_dc85_40df_a830_bad4894a5d92
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

http://identifiers.org/biomodels.db/BIOMD0000000450#b7954479_7a35_42eb_b345_8fa01b769d57
type: Parameter
constant: true
value: 1.0
name: K_hcy_MS

COPASI118
type: Reaction
name: V_ART
fast: false
reversible: true
is version of: R04560

http://identifiers.org/biomodels.db/BIOMD0000000450#_6853c412_fd93_4220_a6ee_c88d4deed819
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

http://identifiers.org/biomodels.db/BIOMD0000000450#_878a57bd_c9a9_4ebf_8bbb_1ba85630a792
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

http://identifiers.org/biomodels.db/BIOMD0000000450#_4594eb04_76ca_46cc_9807_4714fb550274
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

http://identifiers.org/biomodels.db/BIOMD0000000450#_11b61fc0_2688_4fe2_a7bd_74eb10c9368a
type: Reaction
name: VcNE
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#f1cb2dcd_ea03_48f3_9d13_a72239e62e3c
type: SpeciesReference
stoichiometry: 1.0
species: COPASI56

http://identifiers.org/biomodels.db/BIOMD0000000450#c584a180_d38b_467a_bed3_591dff81b2a1
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

http://identifiers.org/biomodels.db/BIOMD0000000450#dc50ffe5_e313_43b1_85d3_fff1e2468ff3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

http://identifiers.org/biomodels.db/BIOMD0000000450#_0bff1eab_656d_4f00_8c1f_4c936c0df9c4
type: Parameter
constant: true
value: 14950.0
name: V_bcysc

COPASI125
type: Reaction
is version of: R0006565
fast: false
reversible: true
name: gluconeogenesis_ser

http://identifiers.org/biomodels.db/BIOMD0000000450#d3b55a3b_5e4d_4f80_92a1_7aedaf12767d
type: SpeciesReference
stoichiometry: 1.0
species: COPASI33

http://identifiers.org/biomodels.db/BIOMD0000000450#c133d118_9803_4628_a709_c0e9c077d859
type: Parameter
constant: true
value: 5.9
name: K_10f_ART

http://identifiers.org/biomodels.db/BIOMD0000000450#_5ef6f774_838f_49d9_81f9_7600e23f12aa
type: Parameter
constant: true
value: 100.0
name: K_aic_ART

http://identifiers.org/biomodels.db/BIOMD0000000450#_480fadb0_0ef6_4e30_972b_cd5e8dbe74d3
type: Parameter
constant: true
value: 5700.0
name: K_cgly

COPASI123
type: Reaction
reversible: true
name: V_DNMT
is version of: R00649
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#d270b963_c4df_42c2_af1e_9f75fa6008a5
type: SpeciesReference
stoichiometry: 1.0
species: COPASI34

http://identifiers.org/biomodels.db/BIOMD0000000450#_858c462b_3840_43a4_b112_a6baa0e6de99
type: SpeciesReference
stoichiometry: 1.0
species: COPASI35

COPASI64
type: Parameter
constant: true
value: 1.0
name: breakfast

COPASI119
type: Reaction
is version of: R02821
fast: false
reversible: true
name: V_BHMT

COPASI15
type: Species
is: C00719
boundary condition: true
name: Betaine
initial concentration: 50.0
has only substance units: false
in compartment: COPASI3
is: CHEBI:17750
initial amount: NaN
constant: true

http://identifiers.org/biomodels.db/BIOMD0000000450#_2446474e_f1db_4c92_a340_1db9c0a709e3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI15

http://identifiers.org/biomodels.db/BIOMD0000000450#_41170aac_1475_4ffd_8f27_802d67e4feda
type: SpeciesReference
stoichiometry: 1.0
species: COPASI32

http://identifiers.org/biomodels.db/BIOMD0000000450#a64bb7c4_fcff_4fc5_8c70_b6c11596f1e3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI58

COPASI58
type: Species
constant: false
in compartment: COPASI5
has only substance units: false
initial amount: NaN
is version of: CHEBI:17724
name: Dimethylglycine
initial concentration: 0.677559463168903
is version of: C01026
boundary condition: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_24f493c5_74e9_44f4_a5ea_080b82997718
type: SpeciesReference
stoichiometry: 1.0
species: COPASI36

http://identifiers.org/biomodels.db/BIOMD0000000450#c648eb0f_d639_453c_a343_aa4598e66eef
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

http://identifiers.org/biomodels.db/BIOMD0000000450#_49530b3a_40f7_4cd4_9069_221f669f8c04
type: Parameter
constant: true
value: 300.0
name: Kp_GCS

http://identifiers.org/biomodels.db/BIOMD0000000450#_20761621_a737_4175_a761_e762b375b3dc
type: Parameter
constant: true
value: 2700.0
name: V_bserc

http://identifiers.org/biomodels.db/BIOMD0000000450#aaadd432_3d8c_4326_aa52_f6b2514b6597
type: Parameter
constant: true
value: 1.0
name: k_out_glu

http://identifiers.org/biomodels.db/BIOMD0000000450#e48fcadb_cf11_470b_a1f2_ac342f82ecfe
type: Reaction
name: V_PGT
fast: false
reversible: true

COPASI13
type: Species
boundary condition: true
initial concentration: 10.0
has only substance units: false
in compartment: COPASI3
name: GAR
is version of: CHEBI:18349
initial amount: NaN
constant: true
is version of: C003838

http://identifiers.org/biomodels.db/BIOMD0000000450#d6986f2f_331b_420a_9554_442d794e13c5
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

http://identifiers.org/biomodels.db/BIOMD0000000450#_6acf59d2_c247_41ef_8bd0_b7eff54cfaed
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

http://identifiers.org/biomodels.db/BIOMD0000000450#_97edb03c_b455_4108_b019_73cdec075113
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

http://identifiers.org/biomodels.db/BIOMD0000000450#b1b419cf_6cec_4e1a_b634_6a2f4d4225f7
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

http://identifiers.org/biomodels.db/BIOMD0000000450#_04f5a0ab_89a2_4d97_bc04_94d0ee2a41ef
type: Parameter
constant: true
value: 16.0
name: K_NADPH_MTHFR

COPASI55
type: Species
has only substance units: false
initial concentration: 20.1
constant: true
initial amount: NaN
is version of: C00504
is version of: CHEBI:27470
in compartment: COPASI5
boundary condition: true
name: Folate

http://identifiers.org/biomodels.db/BIOMD0000000450#_30f3e90c_2b50_4e11_a9ae_c2d98e8cc734
type: Parameter
constant: true
value: 1100.0
name: V_gshLb

COPASI98
type: Reaction
is version of: GO:0015813
fast: false
reversible: true
name: b_glu_import

http://identifiers.org/biomodels.db/BIOMD0000000450#ce9f6201_70d3_4102_a782_af7fccba6bdc
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

COPASI75
type: Parameter
constant: true
value: 300.0
name: Ks_ODC

COPASI65
type: Parameter
constant: true
value: 1.0
name: fasting

http://identifiers.org/biomodels.db/BIOMD0000000450#_38ffaf79_babc_423b_b0ca_c1526714eb0c
type: Parameter
constant: true
value: 300.0
name: Km_MAT3

http://identifiers.org/biomodels.db/BIOMD0000000450#_5b2e3f42_e501_4745_b30b_39ec1a6196ec
type: Parameter
constant: true
value: 22.0
name: K_10f_mFTS

http://identifiers.org/biomodels.db/BIOMD0000000450#_7ba34da7_16cf_40e2_a1b3_312dcc722bc7
type: Parameter
constant: true
value: 7100.0
name: K_gsgLb

http://identifiers.org/biomodels.db/BIOMD0000000450#_1ff28620_394e_4f5f_b619_14eedce42650
type: Parameter
constant: true
value: 5200.0
name: Vf_cSHMT

http://identifiers.org/biomodels.db/BIOMD0000000450#fa7abb7b_402b_4873_8b94_1d03c494fcc3
type: Reaction
name: VmMTCH
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#_742eca9e_b3d6_4b37_ad9e_b2bce5ad1ada
type: SpeciesReference
stoichiometry: 1.0
species: COPASI51

http://identifiers.org/biomodels.db/BIOMD0000000450#a2765951_0eb5_43f9_bad2_52b71d8b9d84
type: SpeciesReference
stoichiometry: 1.0
species: COPASI50

http://identifiers.org/biomodels.db/BIOMD0000000450#_9954693c_e280_408b_ac73_4ceaac02b7f4
type: Parameter
constant: true
value: 5300.0
name: Vm_MTHFR

http://identifiers.org/biomodels.db/BIOMD0000000450#_2ea635cc_1f93_442c_9479_3f0bcacd9494
type: Reaction
reversible: true
name: VcFTS
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_53b6d78c_6d92_424e_a279_37c873046140
type: SpeciesReference
stoichiometry: 1.0
species: COPASI37

http://identifiers.org/biomodels.db/BIOMD0000000450#fbc5b781_839b_403c_9af2_b7f197ff145e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

http://identifiers.org/biomodels.db/BIOMD0000000450#_62a61369_a771_4bdb_8856_65bb0031e86e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

http://identifiers.org/biomodels.db/BIOMD0000000450#e8b9c26d_4216_4dff_96c2_dd930d9fcb5a
type: Parameter
constant: true
value: 1.0
name: k_out_met

http://identifiers.org/biomodels.db/BIOMD0000000450#_8d3b28db_5b06_46e1_a42a_e78d8b033427
type: Parameter
constant: true
value: 1050.0
name: Vm_mFTD

COPASI101
type: Reaction
name: V_c_gsgHb
is version of: GO:0034635
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_72ab3c1c_45cd_4980_9fa3_dcd90daf0e49
type: SpeciesReference
stoichiometry: 1.0
species: COPASI11

http://identifiers.org/biomodels.db/BIOMD0000000450#_3dd3f84a_9ad9_490d_bd9d_600812571c4c
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

COPASI144
type: Reaction
fast: false
reversible: false
name: V_COA

http://identifiers.org/biomodels.db/BIOMD0000000450#_5d6709c4_3f13_4bad_af6a_c4a390060be0
type: SpeciesReference
stoichiometry: 1.0
species: COPASI46

COPASI46
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 160.666609237206
initial amount: NaN
in compartment: COPASI3
name: CoA

http://identifiers.org/biomodels.db/BIOMD0000000450#_43d6c5c6_56d6_4eb0_8f08_bd7795be4bd0
type: SpeciesReference
stoichiometry: 1.0
species: COPASI45

http://identifiers.org/biomodels.db/BIOMD0000000450#_501dabad_0030_4b06_83ec_39d650bbd72d
type: Parameter
constant: true
value: 10000.0
name: V_cser

http://identifiers.org/biomodels.db/BIOMD0000000450#_51cdc832_376f_454c_88ea_993832208cfc
type: Parameter
constant: true
value: 4600.0
name: V_bglyc

http://identifiers.org/biomodels.db/BIOMD0000000450#_65d8694d_835d_4bd8_a6cf_597fba61ef55
type: Parameter
constant: true
value: 3.0
name: K_thf_cFTS

http://identifiers.org/biomodels.db/BIOMD0000000450#_56dd8b49_4c97_447d_a057_42223690cc8a
type: Parameter
constant: true
value: 100.0
name: K_10f_MTCH

http://identifiers.org/biomodels.db/BIOMD0000000450#_32e51370_d4cf_4696_a8c0_2a0397a51afe
type: Parameter
constant: true
value: 4.0
name: K_NADPH_DHFR

http://identifiers.org/biomodels.db/BIOMD0000000450#e75b8a67_d47b_4cbc_af4b_ed9171352765
type: Parameter
constant: true
value: 25.0
name: K_5mf_MS

COPASI142
type: Reaction
name: V_SPDS
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#_5ea704f8_c79b_4bbf_b151_39222a2a14f1
type: LocalParameter
value: 657.0
name: Vmspds

http://identifiers.org/biomodels.db/BIOMD0000000450#_04aab5f0_0c44_4309_bc2d_5fe277fff6f7
type: LocalParameter
value: 40.0
name: Kpspds

http://identifiers.org/biomodels.db/BIOMD0000000450#cb3f49e3_0525_4f2a_a97d_8be8185fd798
type: LocalParameter
value: 100.0
name: Kidspds

http://identifiers.org/biomodels.db/BIOMD0000000450#_3a8ffd72_f548_4a66_a88e_aea8c0008470
type: LocalParameter
value: 0.8
name: Kiaspds

http://identifiers.org/biomodels.db/BIOMD0000000450#_29142ade_be3a_4143_9a94_3942baf0b1e6
type: LocalParameter
value: 0.3
name: KaSpds

http://identifiers.org/biomodels.db/BIOMD0000000450#_97986184_5fba_489f_87e9_90885dcd453d
type: SpeciesReference
stoichiometry: 1.0
species: COPASI38

http://identifiers.org/biomodels.db/BIOMD0000000450#_7875ba6b_9794_493d_bfbf_cc8d7b37f26e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI41

http://identifiers.org/biomodels.db/BIOMD0000000450#_61b94e79_8ecc_4d88_87e4_eaf23b974c93
type: SpeciesReference
stoichiometry: 1.0
species: COPASI39

http://identifiers.org/biomodels.db/BIOMD0000000450#_79e561cc_512f_4557_9aa9_46181fb9d88f
type: Parameter
constant: true
value: 50.0
name: K_thf_SDH

http://identifiers.org/biomodels.db/BIOMD0000000450#_5903a308_10b2_469b_ac26_08226a03515d
type: Parameter
constant: true
value: 150.0
name: K_bmetc

http://identifiers.org/biomodels.db/BIOMD0000000450#_9aa41a78_a9d3_4b33_b3c8_006be71ad19e
type: Parameter
constant: true
value: 2.0
name: K_2cf_MTD

http://identifiers.org/biomodels.db/BIOMD0000000450#_75b989e1_fe1c_4b6c_ae1c_1281f34c3a34
type: Parameter
constant: true
value: 14.0
name: K_2cf_TS

http://identifiers.org/biomodels.db/BIOMD0000000450#_1cdd6dd5_9a9b_4266_adc2_b5bd91783e0d
type: Parameter
constant: true
value: 6.3
name: K_DUMP_TS

http://identifiers.org/biomodels.db/BIOMD0000000450#_5a2bb9cf_e47d_4034_8440_b6167c036ead
type: Parameter
constant: true
value: 0.01
name: Ki_MS

COPASI31
type: Species
is version of: http://identifiers.org/pubchem.compound/834
constant: false
boundary condition: false
has only substance units: false
initial concentration: 32.3047581589977
initial amount: NaN
in compartment: COPASI3
name: Cystathionine

http://identifiers.org/biomodels.db/BIOMD0000000450#fe4aca31_0f56_4e73_acc0_98ae672264b7
type: Parameter
constant: true
value: 3.0E7
name: Vr_mSHMT

http://identifiers.org/biomodels.db/BIOMD0000000450#_543e58e5_569c_483b_a580_50be66efcfd2
type: Reaction
name: V_DMGD
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#b69a5203_a7f1_40aa_bbc6_1c7e5ff0bf4c
type: SpeciesReference
stoichiometry: 1.0
species: COPASI58

http://identifiers.org/biomodels.db/BIOMD0000000450#_069f258c_e896_4f2f_9283_1b955695cfe4
type: SpeciesReference
stoichiometry: 1.0
species: COPASI48

http://identifiers.org/biomodels.db/BIOMD0000000450#e924b7b6_675c_4131_a948_a1bcbf196018
type: SpeciesReference
stoichiometry: 1.0
species: COPASI57

http://identifiers.org/biomodels.db/BIOMD0000000450#_5a2aa034_8bc5_4fbf_8f0d_c9aa51424bf3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI49

COPASI77
type: Parameter
constant: true
value: 0.06
name: Ks_SSAT

http://identifiers.org/biomodels.db/BIOMD0000000450#f29ca30f_ebd9_4ba7_b27f_c9c7a1f7db09
type: Parameter
constant: true
value: 420000.0
name: Vm_CBS

COPASI109
type: Reaction
reversible: true
is version of: R00945
fast: false
name: VmSHMT

COPASI53
type: Species
boundary condition: false
is version of: CHEBI:15428
in compartment: COPASI4
initial amount: NaN
is version of: C00037
name: m_Glycine
initial concentration: 2043.470284255
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_16ecb849_62e5_4c02_a8f2_7511a7cb1cbe
type: SpeciesReference
stoichiometry: 1.0
species: COPASI52

http://identifiers.org/biomodels.db/BIOMD0000000450#_3fdb189e_9390_4c4b_b706_23917b9cfb6b
type: SpeciesReference
stoichiometry: 1.0
species: COPASI48

http://identifiers.org/biomodels.db/BIOMD0000000450#_5828dbd6_2bef_4e0e_aeef_01b72d6fc908
type: SpeciesReference
stoichiometry: 1.0
species: COPASI53

http://identifiers.org/biomodels.db/BIOMD0000000450#_2b097bf4_69fb_425e_bc07_e0c23226d7d8
type: SpeciesReference
stoichiometry: 1.0
species: COPASI49

http://identifiers.org/biomodels.db/BIOMD0000000450#_9fdbae73_ae00_4f7a_9449_c4bd3fc706fe
type: Parameter
constant: true
value: 50.0
name: K_thf_SHMT

http://identifiers.org/biomodels.db/BIOMD0000000450#e4e1f394_c315_41ea_b301_7462e56f84f8
type: Parameter
constant: true
value: 80000.0
name: Vf_cMTD

COPASI93
type: Reaction
is version of: GO:0006546
fast: false
reversible: true
name: b_gly_loss

http://identifiers.org/biomodels.db/BIOMD0000000450#a51e26b0_feb9_4694_874c_d47213828f34
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI107
type: Reaction
fast: false
is version of: GO:0015821
reversible: true
name: V_b_MET_c

COPASI6
type: Species
initial amount: NaN
is version of: C01733
name: b_Methionine
boundary condition: true
in compartment: COPASI2
constant: false
has only substance units: false
initial concentration: 30.0
is version of: CHEBI:16811

http://identifiers.org/biomodels.db/BIOMD0000000450#_04015b9b_2337_44b2_9349_0eebfbe50d5b
type: SpeciesReference
stoichiometry: 1.0
species: COPASI36

http://identifiers.org/biomodels.db/BIOMD0000000450#_90bc49d5_57b7_4300_86c6_578c6e9b0963
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

http://identifiers.org/biomodels.db/BIOMD0000000450#e0931af4_b470_4e72_a88c_42a1808ffd1f
type: Reaction
reversible: true
fast: false
name: V_SDH

http://identifiers.org/biomodels.db/BIOMD0000000450#_6e3f59e1_244c_4f29_907d_7ed7a42e52d6
type: SpeciesReference
stoichiometry: 1.0
species: COPASI49

http://identifiers.org/biomodels.db/BIOMD0000000450#_19a9002a_77d9_49be_bc03_6bf377c93861
type: SpeciesReference
stoichiometry: 1.0
species: COPASI53

http://identifiers.org/biomodels.db/BIOMD0000000450#fdd849a4_d2d9_4577_87eb_f4b76a0b66d5
type: SpeciesReference
stoichiometry: 1.0
species: COPASI48

http://identifiers.org/biomodels.db/BIOMD0000000450#_27e11943_f2ec_499a_81f6_c4a1297e95a3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI57

http://identifiers.org/biomodels.db/BIOMD0000000450#_0d13b85b_e0c3_4308_92b8_9c4a9cd8607d
type: Parameter
constant: true
value: 1.4
name: Km_DNMT

http://identifiers.org/biomodels.db/BIOMD0000000450#_7c6396b6_9a7e_44aa_9542_012ae0721524
type: Parameter
constant: true
value: 0.01
name: Ki_BHMT

COPASI47
type: Species
is version of: C00011
in compartment: COPASI4
name: CO2
initial concentration: 0.0
constant: true
is version of: CHEBI:16526
has only substance units: false
boundary condition: true
initial amount: NaN

COPASI88
type: Reaction
fast: false
name: b_gsh_decomp
reversible: true
is version of: GO:0006751

http://identifiers.org/biomodels.db/BIOMD0000000450#_85a2fa5c_66ce_4da9_bcd0_6a117a35c859
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

http://identifiers.org/biomodels.db/BIOMD0000000450#cdc073f5_0663_48d7_be98_a17d326d980e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

http://identifiers.org/biomodels.db/BIOMD0000000450#_80ec7221_71af_4cf4_9fa8_d0a4e99dfe44
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

http://identifiers.org/biomodels.db/BIOMD0000000450#_1237e1c4_0773_4000_b166_6a3d1516b5af
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

http://identifiers.org/biomodels.db/BIOMD0000000450#_249e45d9_289e_44aa_bdf8_2124eb924b12
type: Parameter
constant: true
value: 2160.0
name: Vm_BHMT

COPASI120
type: Reaction
name: V_MATI
reversible: true
fast: false
is version of: R00650

http://identifiers.org/biomodels.db/BIOMD0000000450#_71d1ce5f_d056_4ea8_9624_a52edf8f97eb
type: SpeciesReference
stoichiometry: 1.0
species: COPASI36

http://identifiers.org/biomodels.db/BIOMD0000000450#bdf187f7_fafc_4bf9_be04_a0e698177ef4
type: SpeciesReference
stoichiometry: 1.0
species: COPASI35

COPASI132
type: Reaction
fast: false
reversible: true
is version of: R00274
name: V_GPX

http://identifiers.org/biomodels.db/BIOMD0000000450#ec3f2726_1234_4d6e_9453_07e4beb792f3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

http://identifiers.org/biomodels.db/BIOMD0000000450#_7f0f5982_2ed4_4d12_aea1_b47f151ca798
type: SpeciesReference
stoichiometry: 2.0
species: COPASI30

http://identifiers.org/biomodels.db/BIOMD0000000450#_6a77f12a_c18a_4de2_b1ab_2e1c6d2b40a3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

http://identifiers.org/biomodels.db/BIOMD0000000450#_94aea1cc_c4b3_488f_819e_b9aa81209cee
type: Parameter
constant: true
value: 3.0
name: K_thf_mFTS

COPASI130
type: Reaction
is version of: GO:0006538
fast: false
reversible: true
name: c_glu_usage

COPASI25
type: Species
boundary condition: false
is version of: C00302
in compartment: COPASI3
has only substance units: false
initial amount: NaN
is version of: CHEBI:18237
initial concentration: 3236.78229408139
constant: false
name: c_Glutamate

http://identifiers.org/biomodels.db/BIOMD0000000450#_507b052f_839f_44b5_9d93_0bf6bee29851
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

http://identifiers.org/biomodels.db/BIOMD0000000450#_797130f5_5dcf_4409_9168_8c6985b44e94
type: Parameter
constant: true
value: 0.035
name: Ka_CBS

COPASI89
type: Reaction
is version of: GO:0006751
name: b_gsg_decomp
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#_571b4ffb_81d5_4699_907a_26759df06e2c
type: SpeciesReference
stoichiometry: 2.0
species: COPASI9

http://identifiers.org/biomodels.db/BIOMD0000000450#c82004e2_5949_47a2_9f73_907072706cdc
type: SpeciesReference
stoichiometry: 2.0
species: COPASI8

http://identifiers.org/biomodels.db/BIOMD0000000450#_18bf4090_331e_42fd_8067_05f9e470a62a
type: SpeciesReference
stoichiometry: 2.0
species: COPASI10

http://identifiers.org/biomodels.db/BIOMD0000000450#_6a170fdc_311b_4120_bad8_d66483f49403
type: SpeciesReference
stoichiometry: 1.0
species: COPASI11

http://identifiers.org/biomodels.db/BIOMD0000000450#cceec877_27d7_4d5d_9b7a_e13ac8726e84
type: Reaction
name: VmGLYc
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_5191369d_4229_44cc_b5ec_27e64721101e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

http://identifiers.org/biomodels.db/BIOMD0000000450#_23ed4c5e_5a9e_403a_bd53_9a411f2cb3ef
type: SpeciesReference
stoichiometry: 3.0
species: COPASI53

COPASI59
type: Parameter
constant: true
value: 0.0
name: Vm_MAT1

http://identifiers.org/biomodels.db/BIOMD0000000450#ab249d22_bb64_4a14_b29e_d7451aa4065e
type: Parameter
constant: true
value: 50.0
name: K_2cf_MTHFR

COPASI133
type: Reaction
reversible: true
fast: false
name: V_GR
is version of: R00115

http://identifiers.org/biomodels.db/BIOMD0000000450#c9d1164c_c0b5_4676_9bc0_4e40f0ecf4a7
type: SpeciesReference
stoichiometry: 2.0
species: COPASI30

http://identifiers.org/biomodels.db/BIOMD0000000450#_41246c9f_f473_4f14_9c4c_98d4e90ad586
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

http://identifiers.org/biomodels.db/BIOMD0000000450#_85c7fb73_a759_48af_b0d8_66bc040e33ed
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

COPASI99
type: Reaction
name: V_c_gshHb
is version of: GO:0034635
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#_4923c573_0e9b_422c_839e_66d608519715
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

http://identifiers.org/biomodels.db/BIOMD0000000450#_88ab7323_fa90_4ac4_a0da_96fb0339a283
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

COPASI72
type: Parameter
constant: false
value: 0.58497831332261
name: ANTZ

http://identifiers.org/biomodels.db/BIOMD0000000450#_42f9e129_4593_4e96_864e_1803bd1fe720
type: Parameter
constant: true
value: 600.0
name: K_ser_SHMT

http://identifiers.org/biomodels.db/BIOMD0000000450#_1692a69e_f53e_4eb1_b7d9_364f5636ba15
type: Parameter
constant: false
value: 13.4
name: tot_cfol

http://identifiers.org/biomodels.db/BIOMD0000000450#_990d8856_72bc_4153_b01b_12ce37c3486a
type: Parameter
constant: false
value: 70.0
name: V_oCys_b

COPASI131
type: Reaction
name: V_GS
reversible: true
is version of: R00497
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#f91534fe_4f44_4fbe_ace7_0f31383457f9
type: SpeciesReference
stoichiometry: 1.0
species: COPASI27

http://identifiers.org/biomodels.db/BIOMD0000000450#df90c8cb_2252_491b_9eee_a6075a861d65
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

http://identifiers.org/biomodels.db/BIOMD0000000450#ce81c310_fd61_4e55_81de_a881213e34be
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

COPASI70
type: Parameter
constant: false
value: 42.2853792055417
name: Vm_SSAT

http://identifiers.org/biomodels.db/BIOMD0000000450#_2ba872af_aa6c_4753_8187_939ee4130cd5
type: Parameter
constant: true
value: 5700.0
name: K_mgly

http://identifiers.org/biomodels.db/BIOMD0000000450#_84fd3993_502a_49c4_acf7_ef469423aaba
type: Parameter
constant: true
value: 11440.0
name: Vf_mSHMT

COPASI128
type: Reaction
reversible: true
name: V_GCS
fast: false
is version of: R00894

http://identifiers.org/biomodels.db/BIOMD0000000450#_7b656eae_428e_4696_8f2f_b03fff3e296b
type: SpeciesReference
stoichiometry: 1.0
species: COPASI26

http://identifiers.org/biomodels.db/BIOMD0000000450#bdb51f22_21ae_4cd9_a94d_cdfd70816ea5
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

http://identifiers.org/biomodels.db/BIOMD0000000450#_7a1fd302_118e_4f1b_a679_bd33398f728e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI27

http://identifiers.org/biomodels.db/BIOMD0000000450#_688c19b5_6f33_44d0_b6ef_c59e08e792d4
type: Parameter
constant: true
value: 20000.0
name: Vr_MTCH

http://identifiers.org/biomodels.db/BIOMD0000000450#_887d69ed_9e17_48ca_ac81_4f877ebd2acf
type: Reaction
name: V_GDC
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#c060b6ef_422a_46b0_b3c9_4ca3eb3fc053
type: SpeciesReference
stoichiometry: 1.0
species: COPASI47

http://identifiers.org/biomodels.db/BIOMD0000000450#ac680a05_fd36_42ef_a5fd_a5bc2e44d35d
type: SpeciesReference
stoichiometry: 1.0
species: COPASI48

http://identifiers.org/biomodels.db/BIOMD0000000450#bb69f0e6_51b8_465e_ad9d_0ef8dec73e57
type: SpeciesReference
stoichiometry: 1.0
species: COPASI53

http://identifiers.org/biomodels.db/BIOMD0000000450#_5dc125ed_9c9f_4f2d_85bd_336ebdcb6346
type: SpeciesReference
stoichiometry: 1.0
species: COPASI49

COPASI126
type: Reaction
reversible: true
name: V_CBS
fast: false
is version of: R01289

http://identifiers.org/biomodels.db/BIOMD0000000450#f2406a6f_aaa6_4ba0_930a_39c8e720b322
type: SpeciesReference
stoichiometry: 1.0
species: COPASI32

http://identifiers.org/biomodels.db/BIOMD0000000450#_9a5649e6_160a_4cae_ad9d_c2bcfe0de002
type: SpeciesReference
stoichiometry: 1.0
species: COPASI33

http://identifiers.org/biomodels.db/BIOMD0000000450#_55404ed6_4127_4b1f_9695_02dc6b6234b3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI31

COPASI138
type: Reaction
name: V_SSAT_S
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#df14f5d9_9e67_4406_bf27_f199aabb6f48
type: SpeciesReference
stoichiometry: 1.0
species: COPASI45

http://identifiers.org/biomodels.db/BIOMD0000000450#_306cb0d7_e3b0_4232_8536_4f4bdc0fc500
type: SpeciesReference
stoichiometry: 1.0
species: COPASI40

http://identifiers.org/biomodels.db/BIOMD0000000450#_04633865_255a_4ab0_8211_b2e0a70f28d4
type: SpeciesReference
stoichiometry: 1.0
species: COPASI42

http://identifiers.org/biomodels.db/BIOMD0000000450#b8bb88cc_6d25_4ccf_b8ff_602aa3b28e1d
type: SpeciesReference
stoichiometry: 1.0
species: COPASI46

http://identifiers.org/biomodels.db/BIOMD0000000450#b131b7b0_1f14_4aef_8f35_bb5557e7d889
type: LocalParameter
value: 35.0
name: Kmsssat

http://identifiers.org/biomodels.db/BIOMD0000000450#_8d6dc4f9_b748_4144_b647_e9f2a3bbaaf4
type: LocalParameter
value: 130.0
name: Kmdssat

http://identifiers.org/biomodels.db/BIOMD0000000450#_5efd34f0_9030_45fb_8c44_a886f4501203
type: LocalParameter
value: 40.0
name: Kmcoassat

http://identifiers.org/biomodels.db/BIOMD0000000450#_0254d908_ac5e_438e_af32_e4fca7a71d5a
type: LocalParameter
value: 1.5
name: Kmaccoassat

http://identifiers.org/biomodels.db/BIOMD0000000450#_6e806e03_186e_4c70_b738_fa5ec580b533
type: LocalParameter
value: 4.44
name: C

http://identifiers.org/biomodels.db/BIOMD0000000450#d4cb72ce_d6b8_49a1_8ccd_5c0531e45ba1
type: Reaction
reversible: true
name: VmMTD
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_37a5574c_76d8_46fa_8cde_1cb3af88549e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI49

http://identifiers.org/biomodels.db/BIOMD0000000450#_3b9eaecb_7558_403a_acd8_bc4b5cb2ae2a
type: SpeciesReference
stoichiometry: 1.0
species: COPASI50

http://identifiers.org/biomodels.db/BIOMD0000000450#_9e02fe38_86f8_429f_9fdd_9049d9521f45
type: Parameter
constant: true
value: 55000.0
name: Vm_ART

http://identifiers.org/biomodels.db/BIOMD0000000450#caf092ca_da29_432c_9cc1_827aad48dbde
type: Parameter
constant: true
value: 4025.0
name: V_gsgLb

COPASI145
type: Reaction
fast: false
reversible: false
name: V_ACCOA

http://identifiers.org/biomodels.db/BIOMD0000000450#_8147af41_1c7a_4ae3_a39b_d59edb6d1704
type: SpeciesReference
stoichiometry: 1.0
species: COPASI45

http://identifiers.org/biomodels.db/BIOMD0000000450#_7fc47fc6_424c_48ed_8d9a_b76749b71a9b
type: SpeciesReference
stoichiometry: 1.0
species: COPASI46

COPASI84
type: Parameter
constant: true
value: 0.24
name: R

COPASI143
type: Reaction
name: V_SPMS
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#dfd8f604_a656_4220_9c29_a77a2ebe0576
type: SpeciesReference
stoichiometry: 1.0
species: COPASI41

http://identifiers.org/biomodels.db/BIOMD0000000450#_819c88fc_362f_4214_a9a3_6e333790de9d
type: LocalParameter
value: 193.8
name: Vmspms

http://identifiers.org/biomodels.db/BIOMD0000000450#_6beb24a8_a221_400d_bb6c_325727a6474f
type: LocalParameter
value: 25.0
name: Kisspms

http://identifiers.org/biomodels.db/BIOMD0000000450#_2ba4d5bd_7f19_45b1_aecd_8fe8fbf8fcb7
type: LocalParameter
value: 0.06
name: Kiaspms

http://identifiers.org/biomodels.db/BIOMD0000000450#_35cef2b4_2e0c_423e_b525_06d3500de236
type: LocalParameter
value: 60.0
name: Kdspms

http://identifiers.org/biomodels.db/BIOMD0000000450#c8f05ddf_bcd4_4c3b_833f_2e4de0248311
type: LocalParameter
value: 0.1
name: Kaspms

http://identifiers.org/biomodels.db/BIOMD0000000450#_85f59844_408e_4835_8435_8f317c0c5892
type: SpeciesReference
stoichiometry: 1.0
species: COPASI40

http://identifiers.org/biomodels.db/BIOMD0000000450#_3128cb29_dc6c_4e44_8154_ae9b3fe7dfe5
type: SpeciesReference
stoichiometry: 1.0
species: COPASI38

COPASI60
type: Parameter
constant: true
value: 0.0
name: Vm_MAT3

http://identifiers.org/biomodels.db/BIOMD0000000450#_0669562d_38cd_4b05_8c34_5b799b8102c9
type: Parameter
constant: true
value: 0.01
name: Ka_GCS

http://identifiers.org/biomodels.db/BIOMD0000000450#fa11c452_d332_4539_adea_4a972c8ff47e
type: Parameter
constant: true
value: 10000.0
name: K_gly_SHMT

COPASI82
type: Parameter
constant: false
value: 0.24
name: K_accoa

http://identifiers.org/biomodels.db/BIOMD0000000450#_3982cb04_7de6_420f_b250_d3974ed1af10
type: Parameter
constant: true
value: 500.0
name: Vm_cFTD

http://identifiers.org/biomodels.db/BIOMD0000000450#_03991def_38f9_43fc_9ce3_ca80cb00fd9e
type: Parameter
constant: true
value: 100.0
name: k_out_coo

http://identifiers.org/biomodels.db/BIOMD0000000450#_649d7b0b_dc3e_47cf_8d30_69dd6c9ee76c
type: Parameter
constant: true
value: 150.0
name: K_bglyc

COPASI139
type: Reaction
name: V_SSAT_D
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#_53a1945a_af53_4c90_ac86_5007411c0df1
type: LocalParameter
value: 35.0
name: Kmsssat

http://identifiers.org/biomodels.db/BIOMD0000000450#_2c03d069_5aeb_4c68_9620_b22f5a83fdb3
type: LocalParameter
value: 130.0
name: Kmdssat

http://identifiers.org/biomodels.db/BIOMD0000000450#_36842cd9_a086_4af5_b2e4_55c3e11692e1
type: LocalParameter
value: 40.0
name: Kmcoassat

http://identifiers.org/biomodels.db/BIOMD0000000450#f68cd7ac_a6fc_4cb0_b198_8095546d78b2
type: LocalParameter
value: 1.5
name: Kmaccoassat

http://identifiers.org/biomodels.db/BIOMD0000000450#_2db3ed3c_0195_4367_bcdd_0beca69cf888
type: SpeciesReference
stoichiometry: 1.0
species: COPASI41

http://identifiers.org/biomodels.db/BIOMD0000000450#_53ada106_2c80_4982_b6d9_b2cff142e443
type: SpeciesReference
stoichiometry: 1.0
species: COPASI45

http://identifiers.org/biomodels.db/BIOMD0000000450#_008d47b8_2db4_42cf_83cb_5335d2f043af
type: SpeciesReference
stoichiometry: 1.0
species: COPASI43

http://identifiers.org/biomodels.db/BIOMD0000000450#_5b8db07f_f36e_416e_914b_3bd5c647925d
type: SpeciesReference
stoichiometry: 1.0
species: COPASI46

http://identifiers.org/biomodels.db/BIOMD0000000450#fffe62c8_5bff_4631_b8ef_86906716369c
type: Parameter
constant: true
value: 12.0
name: K_hcy_BHMT

http://identifiers.org/biomodels.db/BIOMD0000000450#_1e3b17ec_bd49_4138_8398_bf765d40beb7
type: Parameter
constant: true
value: 4030.0
name: Ki_MAT3

http://identifiers.org/biomodels.db/BIOMD0000000450#_8b015c1f_c2e8_443a_a12a_0bcd65014cba
type: Parameter
constant: true
value: 100.0
name: k_in_coo

http://identifiers.org/biomodels.db/BIOMD0000000450#a3601f5c_f996_48d6_a1fa_c10d1fcea9d0
type: Parameter
constant: true
value: 594000.0
name: Vr_MTD

http://identifiers.org/biomodels.db/BIOMD0000000450#_2d419287_9629_4740_a18e_6fd67bc7696c
type: Parameter
constant: true
value: 30.0
name: Kp_GS

http://identifiers.org/biomodels.db/BIOMD0000000450#daccfe79_1b0e_4ffb_95b8_233af4075cc8
type: Parameter
constant: true
value: 4530.0
name: Vr_SAHH

http://identifiers.org/biomodels.db/BIOMD0000000450#_52b7bcc5_bd3b_46c6_8f7d_3db1d3f8b09a
type: Parameter
constant: true
value: 790000.0
name: Vf_mMTCH

COPASI85
type: Parameter
constant: false
value: 140.951264018472
name: S+D

http://identifiers.org/biomodels.db/BIOMD0000000450#ebdf9b25_7b31_47ef_ba78_0b99b214e7ef
type: Parameter
constant: true
value: 15000.0
name: Vm_GDC

COPASI61
type: Parameter
constant: true
value: 10.4
name: K_NADPH_GR

http://identifiers.org/biomodels.db/BIOMD0000000450#_4945db52_6faf_4221_bd71_a9900e37effe
type: Parameter
constant: true
value: 4.9
name: K_10f_PGT

http://identifiers.org/biomodels.db/BIOMD0000000450#b507db25_682e_4a28_9f81_91ac21cb617e
type: Parameter
constant: true
value: 18.0
name: Ki_GNMT

COPASI83
type: Parameter
constant: false
value: 0.72
name: K_coa

http://identifiers.org/biomodels.db/BIOMD0000000450#_7edeeb78_532e_41f2_afaa_b5574cce7d5d
type: Parameter
constant: true
value: 8200.0
name: Ki_GCS

COPASI104
type: Reaction
is version of: GO:0015813
reversible: true
fast: false
name: V_b_GLU_c

http://identifiers.org/biomodels.db/BIOMD0000000450#_97250561_5191_4e34_920a_fc67702e60b4
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

http://identifiers.org/biomodels.db/BIOMD0000000450#f07235c6_c41a_4b21_9a4e_df82f1c2502d
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

http://identifiers.org/biomodels.db/BIOMD0000000450#f253e258_f33f_42ab_b016_a1571419af3a
type: Parameter
constant: true
value: 15000.0
name: Vm_DMGD

http://identifiers.org/biomodels.db/BIOMD0000000450#_52573217_fc0e_4fe8_95e4_b4038a847c03
type: Parameter
constant: true
value: 130.0
name: K_gly_GNMT

COPASI116
type: Reaction
is version of: R01220
fast: false
reversible: true
name: VcMTD

http://identifiers.org/biomodels.db/BIOMD0000000450#_1a64a55a_6e41_4693_b56b_ab9df32f77b4
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

COPASI21
type: Species
is version of: http://identifiers.org/pubchem.compound/644350
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259497676806752
initial amount: NaN
in compartment: COPASI3
name: c_5-10-methenyl-THF

http://identifiers.org/biomodels.db/BIOMD0000000450#_5258bab9_b548_4c97_b11c_c8485b832489
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

http://identifiers.org/biomodels.db/BIOMD0000000450#_9585c222_ddd4_42db_9f62_68d3f30ec550
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

http://identifiers.org/biomodels.db/BIOMD0000000450#_73cc5a0f_b22a_4707_8143_6599bc2e3a3d
type: Parameter
constant: true
value: 2000.0
name: K_ser_CBS

http://identifiers.org/biomodels.db/BIOMD0000000450#_7e451daa_aaed_4c9c_b43a_534b264804e9
type: Parameter
constant: true
value: 3400.0
name: K_gly_GDC

http://identifiers.org/biomodels.db/BIOMD0000000450#a52eb7b0_5073_4cc3_8b03_f1eed8a3b11b
type: Parameter
constant: true
value: 6.5
name: K_sah_SAHH

COPASI102
type: Reaction
reversible: true
name: V_c_gsgLb
is version of: GO:0034635
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_99de3d1e_0dcd_483b_89f5_f674a1678d29
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

http://identifiers.org/biomodels.db/BIOMD0000000450#_2d1eda74_36a4_493f_8476_0f7ae4fbcc5c
type: SpeciesReference
stoichiometry: 1.0
species: COPASI11

http://identifiers.org/biomodels.db/BIOMD0000000450#_71057530_bb5e_4cfa_a90a_221505a213ef
type: Parameter
constant: true
value: 250.0
name: K_1cf_MTCH

http://identifiers.org/biomodels.db/BIOMD0000000450#_7656777e_9112_457c_943d_d633f693c1fe
type: Parameter
constant: true
value: 500000.0
name: Vf_cMTCH

COPASI114
type: Reaction
name: V_TS
is version of: R02101
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#fb28b1f4_1fa3_42d5_af50_b8b0533e4943
type: SpeciesReference
stoichiometry: 1.0
species: COPASI16

http://identifiers.org/biomodels.db/BIOMD0000000450#_2555d980_bfcb_4db8_8381_c6b2e72a2c7d
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

http://identifiers.org/biomodels.db/BIOMD0000000450#_7ef0cab0_1953_4520_a26b_44776b41e373
type: SpeciesReference
stoichiometry: 1.0
species: COPASI23

http://identifiers.org/biomodels.db/BIOMD0000000450#bc948491_5101_4690_b200_5c7a090e82a4
type: Parameter
constant: true
value: 10.0
name: K_1cf_MTD

http://identifiers.org/biomodels.db/BIOMD0000000450#e2401af5_0e19_46f1_b2c6_e00e5bcc79c6
type: Reaction
name: VmSERc
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#ae0ce0ca_8a44_46cb_8306_722ab4439a8a
type: SpeciesReference
stoichiometry: 3.0
species: COPASI52

http://identifiers.org/biomodels.db/BIOMD0000000450#f1809d51_8168_42d5_9a56_a8222775a4a3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI33

http://identifiers.org/biomodels.db/BIOMD0000000450#cd7e3281_ad1c_4b95_85e5_0113d3d88195
type: Parameter
constant: true
value: 3200.0
name: K_2cf_SHMT

http://identifiers.org/biomodels.db/BIOMD0000000450#c62ebbb8_8336_4a3a_8449_836d2e351e2b
type: Parameter
constant: true
value: 1900.0
name: K_glu_GCS

COPASI121
type: Reaction
fast: false
name: V_MATIII
is version of: R00650
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#dd3a3412_a87a_4e9d_b0ce_457f05991e45
type: SpeciesReference
stoichiometry: 1.0
species: COPASI36

http://identifiers.org/biomodels.db/BIOMD0000000450#_8902511a_d55b_4cc7_8949_2df3fda55f76
type: SpeciesReference
stoichiometry: 1.0
species: COPASI35

http://identifiers.org/biomodels.db/BIOMD0000000450#_0c4610cc_3bb2_41bc_a0df_c5b733a4b4c2
type: Parameter
constant: true
value: 600000.0
name: Vr_cMTD

http://identifiers.org/biomodels.db/BIOMD0000000450#_72bc2747_0576_43a5_81ad_a43f60619bf9
type: Parameter
constant: true
value: 520.0
name: K_GAR_PGT

COPASI117
type: Reaction
name: VcMTCH
is version of: R01655
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_2ad88f7f_6312_4607_a87b_da3d8ffada96
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

http://identifiers.org/biomodels.db/BIOMD0000000450#_3e12f6f5_dffa_45a1_90d5_64d134ea9077
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

http://identifiers.org/biomodels.db/BIOMD0000000450#_62b594f2_e7de_4050_ad1a_514f4d60f303
type: Parameter
constant: true
value: 150.0
name: K_gshHb

http://identifiers.org/biomodels.db/BIOMD0000000450#_3fbf8d1e_a0f1_4578_9945_b8dc3f24ad91
type: Parameter
constant: true
value: 5700.0
name: K_mser

COPASI115
type: Reaction
is version of: R01220
name: V_MTHFR
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_2892ae90_eb04_437b_8753_0261c99ee499
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

http://identifiers.org/biomodels.db/BIOMD0000000450#_922588a5_32cb_421a_9c47_1188a20f2cc3
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

http://identifiers.org/biomodels.db/BIOMD0000000450#_8dc8deb1_c4d1_4791_95af_d6d1abbb259a
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

http://identifiers.org/biomodels.db/BIOMD0000000450#_7ab43b8f_033d_4ac8_9c95_1d3240a23a90
type: Parameter
constant: true
value: 30.0
name: b_met_basal

COPASI96
type: Reaction
is version of: GO:0042883
fast: false
reversible: true
name: b_cys_import

http://identifiers.org/biomodels.db/BIOMD0000000450#_32bc358b_583f_446a_a15c_53fdcf43645e
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

COPASI78
type: Parameter
constant: true
value: 1.2
name: Kd_SAMDC

COPASI73
type: Parameter
constant: true
value: 1.0
name: Ke_POL

COPASI90
type: Reaction
is version of: GO:0019456
fast: false
reversible: true
name: b_cys_cystine_conv

http://identifiers.org/biomodels.db/BIOMD0000000450#_267923a8_462f_41df_b412_e7c48c9476ad
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

COPASI94
type: Reaction
is version of: GO:0006751
fast: false
reversible: true
name: b_gsh_loss

http://identifiers.org/biomodels.db/BIOMD0000000450#_73f8a3df_9a5d_43fe_b80e_1a3fd8bdce40
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

COPASI71
type: Parameter
constant: false
value: 21.1340139923629
name: Vm_SAMDC

http://identifiers.org/biomodels.db/BIOMD0000000450#e923b83d_0568_4ba1_a851_f758391cf942
type: Parameter
constant: true
value: 3600.0
name: Vm_GCS

COPASI129
type: Reaction
is version of: GO:0009093
fast: false
reversible: true
name: cys_usage

http://identifiers.org/biomodels.db/BIOMD0000000450#_60c2d739_aa73_40f5_8801_1ccb15f8a0db
type: SpeciesReference
stoichiometry: 1.0
species: COPASI26

http://identifiers.org/biomodels.db/BIOMD0000000450#c22b60a0_e3d4_4e0d_a687_94516a1398ab
type: Parameter
constant: true
value: 1.4
name: Ki_DNMT

COPASI127
type: Reaction
name: V_CTGL
is version of: R00894
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#d96103fe_b8ea_47e4_94d3_7626b0e1fdd6
type: SpeciesReference
stoichiometry: 1.0
species: COPASI31

http://identifiers.org/biomodels.db/BIOMD0000000450#_9aa98476_afd3_4d38_97d1_c37a1fd425b2
type: SpeciesReference
stoichiometry: 1.0
species: COPASI26

http://identifiers.org/biomodels.db/BIOMD0000000450#_6e75ca45_6008_4fdf_8fce_c260db2fd694
type: Parameter
constant: true
value: 1250.0
name: K_gsgHb

http://identifiers.org/biomodels.db/BIOMD0000000450#_47f47a3f_b692_4b55_8ab4_0f308aa751a9
type: Parameter
constant: true
value: 50.0
name: K_dmg_DMGD

COPASI68
type: Parameter
constant: true
value: 70.0
name: V_oCys_b_basal

http://identifiers.org/biomodels.db/BIOMD0000000450#_75b7e5f6_23d6_4266_b33e_ba864bac1789
type: Parameter
constant: true
value: 500.0
name: Vm_MS

http://identifiers.org/biomodels.db/BIOMD0000000450#fb7f9665_56b9_49c6_bff2_32631c2c7791
type: Parameter
constant: true
value: 1.5E7
name: Vr_cSHMT

http://identifiers.org/biomodels.db/BIOMD0000000450#_22a39dcb_cced_4467_9107_3793b6ea36c9
type: Parameter
constant: true
value: 20.0
name: k2_mNE

http://identifiers.org/biomodels.db/BIOMD0000000450#_5ce9721e_773a_4c61_babf_c9aa1cd4c092
type: Parameter
constant: true
value: 20.0
name: K_10f_FTD

COPASI66
type: Parameter
constant: false
value: 0.0
name: daytime

COPASI140
type: Reaction
fast: false
name: V_PAO_AD
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000450#a7c0f23a_771c_445a_949b_721ab91f1beb
type: SpeciesReference
stoichiometry: 1.0
species: COPASI43

http://identifiers.org/biomodels.db/BIOMD0000000450#d1a9d0e1_7d85_4efb_b84e_ead89149c606
type: SpeciesReference
stoichiometry: 1.0
species: COPASI39

http://identifiers.org/biomodels.db/BIOMD0000000450#_453f7173_fb74_45d6_9094_e60986f70e78
type: LocalParameter
value: 621.0
name: Vmpao

http://identifiers.org/biomodels.db/BIOMD0000000450#_6f5a1ebe_fb09_4327_bb3e_958cf1f2818f
type: LocalParameter
value: 15.0
name: Kmspao

http://identifiers.org/biomodels.db/BIOMD0000000450#c613ed33_f159_4bf5_9f74_c5f8ef63c3db
type: LocalParameter
value: 50.0
name: Kmdpao

http://identifiers.org/biomodels.db/BIOMD0000000450#ea4cdc43_d8d0_4f46_a1fc_e62181fc480b
type: LocalParameter
value: 0.6
name: Kmaspao

http://identifiers.org/biomodels.db/BIOMD0000000450#_4dba9c26_b7de_45ab_b55c_6e8ff0881d5b
type: LocalParameter
value: 14.0
name: Kmadpao

http://identifiers.org/biomodels.db/BIOMD0000000450#fc000ab0_2555_464c_9e6d_fe3fd64eb5a1
type: Parameter
constant: true
value: 24300.0
name: Vm_PGT

http://identifiers.org/biomodels.db/BIOMD0000000450#_06ff6d47_1f74_4668_a61b_aa4e454cae14
type: Parameter
constant: true
value: 3900.0
name: Vm_cFTS

http://identifiers.org/biomodels.db/BIOMD0000000450#a9652c27_65d9_44ba_9b2f_c88dd077df07
type: Parameter
constant: true
value: 1.0
name: k_out_gly

http://identifiers.org/biomodels.db/BIOMD0000000450#_8192fcc4_8760_41b0_aef7_e5cfface74c8
type: Parameter
constant: true
value: 360.0
name: Ka_MAT3

COPASI69
type: Parameter
constant: false
value: 72.2557178994351
name: Vm_ODC

http://identifiers.org/biomodels.db/BIOMD0000000450#a2662811_ffa9_4665_95fc_baca8789bce4
type: Parameter
constant: true
value: 10000.0
name: V_cgly

http://identifiers.org/biomodels.db/BIOMD0000000450#af6728cb_c97d_425e_bd17_75090f39ceda
type: Parameter
constant: true
value: 0.09
name: K_H2O2_GPX

http://identifiers.org/biomodels.db/BIOMD0000000450#_5c609c23_6c48_44a6_9f35_91ee7625a1ec
type: Parameter
constant: true
value: 6300.0
name: Vr_mFTS

COPASI67
type: Parameter
constant: false
value: 1.0
name: Aminoacid_input

http://identifiers.org/biomodels.db/BIOMD0000000450#_76630329_c79a_4d31_83fb_f97537806dd5
type: Parameter
constant: true
value: 0.01
name: ssH2O2

http://identifiers.org/biomodels.db/BIOMD0000000450#_47e429c2_7bb5_4c21_80f7_c9ce4f930caf
type: Parameter
constant: true
value: 50.0
name: K_thf_GDC

http://identifiers.org/biomodels.db/BIOMD0000000450#ba8f3d16_3416_434d_a056_910a99408a5d
type: Parameter
constant: true
value: 1500.0
name: Vm_CTGL

http://identifiers.org/biomodels.db/BIOMD0000000450#bfd6d891_32b9_4b0a_a776_cf60d2a9b007
type: Parameter
constant: true
value: 10000.0
name: V_mgly

COPASI105
type: Reaction
fast: false
reversible: true
name: V_b_GLY_c
is version of: GO:0015816

http://identifiers.org/biomodels.db/BIOMD0000000450#_74d40020_3ea6_41f9_9b22_1b9b31216622
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

http://identifiers.org/biomodels.db/BIOMD0000000450#_737c1186_186d_4c06_900e_b6a1f26ca788
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI148
type: Reaction
reversible: true
name: V_MATII
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000450#_122de929_735f_41f9_b587_8adb3a6bf713
type: SpeciesReference
stoichiometry: 1.0
species: COPASI35

http://identifiers.org/biomodels.db/BIOMD0000000450#_7c99204e_059b_465e_959f_20fb4b8ed1e2
type: LocalParameter
value: 4.0
name: Km

http://identifiers.org/biomodels.db/BIOMD0000000450#dbb75068_5026_43a4_ba3f_fdf9c7a01465
type: LocalParameter
value: 50.0
name: Ki

http://identifiers.org/biomodels.db/BIOMD0000000450#_7cc662e8_8795_481d_a956_0f37da460adb
type: SpeciesReference
stoichiometry: 1.0
species: COPASI36

http://identifiers.org/biomodels.db/BIOMD0000000450#_146e215d_2abe_44c9_bac8_4b1ad643540a
type: Parameter
constant: false
value: 40.2
name: tot_mfol