BIOMD0000000435
type: SBMLModel
species: 103118
volume units: 103022
reaction: COPASI5
species: 103094
reaction: COPASI4
creator:
  ORG:
    orgname: Dresden University of Technology
  n:
    given: Lutz
    family: Brusch
time units: 103046
curated: true
reaction: COPASI3
is: MODEL1211010000
function def: COPASI11
compartment: COPASI2
units def: 103022
units def: 103070
is part of: GO:0031016
species: 103106
units def: 103046
reaction: COPASI9
function def: COPASI12
is described by: http://identifiers.org/pubmed/23193107
is version of: GO:0007267
reaction: COPASI8
name: Lateral inhibition [1]
reaction: COPASI10
reaction: COPASI7
substance units: 103070
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
created:
  W3 CDTF: Wed Nov 28 13:53:36 GMT 2012
reaction: COPASI6
species: 103130
modified:
  W3 CDTF: Tue Feb 12 15:33:48 GMT 2013
name: Lateral stabilisation [1]
notes: deBack2012 - Lineage Specification in Pancreas Development This model of two neighbouring pancreas precursor cells, describes the exocrine versus endocrine lineage specification process. To account for the tissue scale patterns, this couplet model has been extended to hundreds of coupled cells. This model is described in the article: On the role of lateral stabilization during early patterning in the pancreas de Back W., Zhou JX, Brusch L J. R. Soc. Interface 6 February 2013 vol. 10 no. 79 20120766 Abstract: The cell fate decision of multi-potent pancreatic progenitor cells between the exocrine and endocrine lineages is regulated by Notch signalling, mediated by cell–cell interactions. However, canonical models of Notch-mediated lateral inhibition cannot explain the scattered spatial distribution of endocrine cells and the cell-type ratio in the developing pancreas. Based on evidence from acinar-to-islet cell transdifferentiation in vitro, we propose that lateral stabilization, i.e. positive feedback between adjacent progenitor cells, acts in parallel with lateral inhibition to regulate pattern formation in the pancreas. A simple mathematical model of transcriptional regulation and cell–cell interaction reveals the existence of multi-stability of spatial patterns whose simultaneous occurrence causes scattering of endocrine cells in the presence of noise. The scattering pattern allows for control of the endocrine-to-exocrine cell-type ratio by modulation of lateral stabilization strength. These theoretical results suggest a previously unrecognized role for lateral stabilization in lineage specification, spatial patterning and cell-type ratio control in organ development. This model is hosted on BioModels Database and identified by: MODEL1211010000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouri…
area units: 844749
length unit: 844677
occurs in: http://identifiers.org/taxonomy/39107
name: deBack2012 - Lineage Specification in Pancreas Development

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kind: LITRE

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modifier: 814241
modifier: 814229
reversible: false
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