BIOMD0000000424
type: SBMLModel
reaction: 139923
parameter: 140021
parameter: 140134
parameter: 140154
species: 139710
reaction: 139906
parameter: 140116
reaction: 139824
reaction: 139859
parameter: 140073
parameter: 140187
parameter: 140020
parameter: 140153
species: 139780
species: 139770
reaction: 139846
parameter: 140059
parameter: 140173
parameter: 140142
reaction: 139897
species: 139764
species: 139754
parameter: 140139
parameter: 140158
parameter: 140123
reaction: 139828
species: 139702
reaction: 139850
species: 139774
parameter: 140141
parameter: 140178
parameter: 140160
reaction: 139913
species: 139758
parameter: 140082
reaction: 139885
parameter: 140180
species: 139794
parameter: 140013
parameter: 140177
parameter: 140146
species: 139801
species: 139708
reaction: 139888
species: 139778
parameter: 140128
parameter: 140032
reaction: 139874
species: 139798
parameter: 140165
parameter: 140071
reaction: 139840
parameter: 140185
species: 139690
species: 139742
parameter: 140068
parameter: 140151
parameter: 140171
reaction: 139862
curated: true
parameter: 140004
parameter: 140023
parameter: 140137
parameter: 140156
species: 139684
parameter: 140094
species: 139748
reaction: 139909
reaction: 139826
substance units: substance
species: 139678
parameter: 140056
parameter: 140076
reaction: 139845
reaction: 139912
compartment: 139677
reaction: 139882
species: 139726
reaction: 139831

139923
type: Reaction
kinetic law: 975747
product: 975735
reactant: 975723
fast: true
reversible: false
name: R36

975735
type: SpeciesReference
stoichiometry: 1.0
species: 139793

139793
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
occurs in: GO:0005737
initial concentration: 0.0
has part: P04626
in compartment: 139677
has part: CHEMBL2007641

139677
type: Compartment
is: GO:0005886
is: SBO:0000410
constant: false
size: 1.0
spatial dimensions: 3.0

975723
type: SpeciesReference
stoichiometry: 1.0
species: 139707

139707
type: Species
has part: AAC37531.1
initial concentration: 0.0
in compartment: 139677
initial amount: NaN
constant: false
boundary condition: false
has part: P04626
is version of: http://identifiers.org/ec-code/2.7.10.1
has part: CHEMBL2007641
has only substance units: false

140021
type: Parameter
constant: false
value: 0.0

140134
type: Parameter
constant: false
value: 100.0

140154
type: Parameter
constant: false
value: 0.1

139710
type: Species
has part: http://identifiers.org/pubchem.compound/24755492
has part: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

139906
type: Reaction
kinetic law: 975471
product: 975459
product: 975447
reactant: 975435
fast: true
reversible: false
name: R31_3

975459
type: SpeciesReference
stoichiometry: 1.0
species: 139723

139723
type: Species
is version of: P63151
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 139677

975447
type: SpeciesReference
stoichiometry: 1.0
species: 139751

139751
type: Species
has part: http://identifiers.org/pubchem.compound/24755492
has part: P31749
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

975435
type: SpeciesReference
stoichiometry: 1.0
species: 139730

139730
type: Species
constant: false
initial concentration: 0.0
has only substance units: false
has part: P31749
in compartment: 139677
has part: P63151
boundary condition: false
initial amount: NaN
has part: http://identifiers.org/pubchem.compound/24755492

140116
type: Parameter
constant: false
value: 1.0

139824
type: Reaction
kinetic law: 973960
product: 973948
product: 973936
reactant: 973924
fast: true
reversible: false
name: R8

973948
type: SpeciesReference
stoichiometry: 1.0
species: 139792

139792
type: Species
has part: P62993
initial amount: NaN
initial concentration: 0.0
boundary condition: false
constant: false
has only substance units: false
has part: Q07889
has part: P29353
in compartment: 139677
has part: Q07890

973936
type: SpeciesReference
stoichiometry: 1.0
species: 139693

139693
type: Species
initial concentration: 0.0
in compartment: 139677
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
has part: P04626
has part: http://identifiers.org/ec-code/2.7.10.1
is version of: C00562
has part: Q02297
has part: P21860

973924
type: SpeciesReference
stoichiometry: 1.0
species: 139706

139706
type: Species
has part: P62993
in compartment: 139677
has only substance units: false
has part: Q07890
has part: Q02297
has part: http://identifiers.org/ec-code/2.7.10.1
has part: P29353
has part: P21860
boundary condition: false
has part: P04626
is version of: C00562
has part: Q07889
initial amount: NaN
constant: false
initial concentration: 0.0

139859
type: Reaction
kinetic law: 974715
modifier: 974703
product: 974691
reactant: 974679
fast: true
reversible: false
name: R21

139780
type: Species
is version of: C00562
is version of: Q02750
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

974691
type: SpeciesReference
stoichiometry: 1.0
species: 139794

139794
type: Species
is version of: C00562
is version of: P27361
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

974679
type: SpeciesReference
stoichiometry: 1.0
species: 139739

139739
type: Species
is version of: C00562
is version of: P27361
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

140073
type: Parameter
constant: false
value: 0.0154

140187
type: Parameter
constant: false
value: 100.0

140020
type: Parameter
constant: false
value: 0.0

140153
type: Parameter
constant: false
value: 3.0

139770
type: Species
has part: P60484
has part: CHEBI:15552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 5.02914E-8
initial amount: NaN
in compartment: 139677

139846
type: Reaction
kinetic law: 974499
product: 974487
reactant: 974475
reactant: 974463
fast: true
reversible: false
name: R18_1

974487
type: SpeciesReference
stoichiometry: 1.0
species: 139733

139733
type: Species
initial concentration: 0.0
has part: P63151
constant: false
boundary condition: false
in compartment: 139677
is version of: C00562
has only substance units: false
initial amount: NaN
has part: Q02750

974475
type: SpeciesReference
stoichiometry: 1.0
species: 139723

974463
type: SpeciesReference
stoichiometry: 1.0
species: 139780

140059
type: Parameter
constant: false
value: 36.0

140173
type: Parameter
constant: false
value: 0.0

140142
type: Parameter
constant: false
value: 150.0

139897
type: Reaction
kinetic law: 975339
product: 975327
reactant: 975315
fast: true
reversible: false
name: R30

975327
type: SpeciesReference
stoichiometry: 1.0
species: 139775

139775
type: Species
initial concentration: 0.0
constant: false
has part: P31749
in compartment: 139677
is version of: C00562
has only substance units: false
has part: http://identifiers.org/pubchem.compound/24755492
boundary condition: false
initial amount: NaN

975315
type: SpeciesReference
stoichiometry: 1.0
species: 139751

139764
type: Species
initial concentration: 8.05772E-12
in compartment: 139677
is version of: C05981
initial amount: NaN
is version of: CHEBI:16618
boundary condition: false
constant: false
is version of: http://identifiers.org/pubchem.compound/24755492
has only substance units: false

139754
type: Species
is version of: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

140139
type: Parameter
constant: false
value: 0.01

140158
type: Parameter
constant: false
value: 0.001

140123
type: Parameter
constant: false
value: 0.06

139828
type: Reaction
kinetic law: 974128
product: 974116
reactant: 974104
fast: true
reversible: false
name: R12

974116
type: SpeciesReference
stoichiometry: 1.0
species: 139709

139709
type: Species
has part: P01116
has part: CHEBI:17552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 139677

974104
type: SpeciesReference
stoichiometry: 1.0
species: 139798

139798
type: Species
has part: P01116
has part: CHEBI:15996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

139702
type: Species
initial amount: NaN
is version of: C00562
in compartment: 139677
has only substance units: false
initial concentration: 0.0
has part: P04626
has part: Q02297
has part: P21860
boundary condition: false
has part: http://identifiers.org/ec-code/2.7.10.1
has part: P29353
constant: false

139850
type: Reaction
kinetic law: 974583
product: 974571
product: 974559
reactant: 974547
fast: true
reversible: false
name: R18_3

974571
type: SpeciesReference
stoichiometry: 1.0
species: 139723

974559
type: SpeciesReference
stoichiometry: 1.0
species: 139720

139720
type: Species
is version of: C00562
is version of: Q02750
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

974547
type: SpeciesReference
stoichiometry: 1.0
species: 139726

139726
type: Species
has only substance units: false
initial concentration: 0.0
is version of: C00562
has part: P63151
constant: false
has part: Q02750
in compartment: 139677
initial amount: NaN
boundary condition: false

139774
type: Species
is version of: P60484
constant: false
is version of: GO:0043234
in compartment: 139677
boundary condition: false
initial amount: NaN
has only substance units: false
is version of: C00562
initial concentration: 0.955337

140141
type: Parameter
constant: false
value: 3.6

140178
type: Parameter
constant: false
value: 300.0

140160
type: Parameter
constant: false
value: 20000.0

139913
type: Reaction
kinetic law: 975591
product: 975579
reactant: 975567
fast: true
reversible: false
name: R33_2

975579
type: SpeciesReference
stoichiometry: 1.0
species: 139758

139758
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 0.0
has part: P31749
constant: false
in compartment: 139677
is version of: C00562
has part: P63151
has part: http://identifiers.org/pubchem.compound/24755492

975567
type: SpeciesReference
stoichiometry: 1.0
species: 139786

139786
type: Species
in compartment: 139677
boundary condition: false
has part: P63151
constant: false
initial concentration: 0.0
has part: P31749
is version of: C00562
initial amount: NaN
has only substance units: false
has part: http://identifiers.org/pubchem.compound/24755492

140082
type: Parameter
constant: false
value: 1.0

139885
type: Reaction
kinetic law: 975183
product: 975171
reactant: 975159
reactant: 975147
fast: true
reversible: false
name: R28_5

975171
type: SpeciesReference
stoichiometry: 1.0
species: 139774

975159
type: SpeciesReference
stoichiometry: 1.0
species: 139773

139773
type: Species
is version of: C00562
is version of: P60484
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.39885
initial amount: NaN
in compartment: 139677

975147
type: SpeciesReference
stoichiometry: 1.0
species: 139761

139761
type: Species
is version of: C05981
has only substance units: false
boundary condition: false
constant: false
is version of: http://identifiers.org/ec-code/3.1.3.16
in compartment: 139677
is version of: P60484
initial concentration: 42.7798
initial amount: NaN

140180
type: Parameter
constant: false
value: 0.0

140013
type: Parameter
constant: false
value: 70.0

140177
type: Parameter
constant: false
value: 50.0

140146
type: Parameter
constant: false
value: 150.0

139801
type: Species
is version of: C00562
is version of: P29353
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

139708
type: Species
initial concentration: 0.0
has part: P60484
in compartment: 139677
boundary condition: false
constant: false
has part: AAH05821.1
has part: http://identifiers.org/pubchem.compound/16760324
initial amount: NaN
has only substance units: false

139888
type: Reaction
kinetic law: 975219
product: 975207
reactant: 975195
fast: true
reversible: false
name: R28_6

975207
type: SpeciesReference
stoichiometry: 1.0
species: 139778

139778
type: Species
is version of: GO:0043234
is version of: P60484
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.955337
initial amount: NaN
in compartment: 139677

975195
type: SpeciesReference
stoichiometry: 1.0
species: 139774

140128
type: Parameter
constant: false
value: 0.06

140032
type: Parameter
constant: false
value: 0.01

139874
type: Reaction
kinetic law: 974967
product: 974955
reactant: 974943
reactant: 974931
fast: true
reversible: false
name: R27_1

974955
type: SpeciesReference
stoichiometry: 1.0
species: 139779

139779
type: Species
has part: CHEBI:16618
has part: CHEBI:15552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

974943
type: SpeciesReference
stoichiometry: 1.0
species: 139754

974931
type: SpeciesReference
stoichiometry: 1.0
species: 139755

139755
type: Species
is version of: C01312
is version of: CHEBI:15552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: 139677

140165
type: Parameter
constant: false
value: 100.0

140071
type: Parameter
constant: false
value: 35.0

139840
type: Reaction
kinetic law: 974319
product: 974307
reactant: 974295
reactant: 974283
fast: true
reversible: false
name: R16_1

974307
type: SpeciesReference
stoichiometry: 1.0
species: 139726

974295
type: SpeciesReference
stoichiometry: 1.0
species: 139723

974283
type: SpeciesReference
stoichiometry: 1.0
species: 139720

140185
type: Parameter
constant: false
value: 100.0

139690
type: Species
has only substance units: false
constant: false
has part: http://identifiers.org/ec-code/2.7.10.1
boundary condition: false
initial concentration: 0.0
has part: Q02297
has part: P21860
initial amount: NaN
in compartment: 139677
has part: P04626

139742
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
in compartment: 139677
occurs in: GO:0005737
has part: P21860
has part: http://identifiers.org/ec-code/2.7.10.1
has part: Q02297
initial concentration: 0.0

140068
type: Parameter
constant: false
value: 0.1

140151
type: Parameter
constant: false
value: 0.1

140171
type: Parameter
constant: false
value: 0.0

139862
type: Reaction
kinetic law: 974751
product: 974739
reactant: 974727
fast: true
reversible: false
name: R22

974739
type: SpeciesReference
stoichiometry: 1.0
species: 139739

974727
type: SpeciesReference
stoichiometry: 1.0
species: 139794

140004
type: Parameter
constant: false
value: 10.0

140023
type: Parameter
constant: false
value: 600.0

140137
type: Parameter
constant: false
value: 8000.0

140156
type: Parameter
constant: false
value: 30.0

139684
type: Species
initial concentration: 0.0
in compartment: 139677
initial amount: NaN
has only substance units: false
has part: http://identifiers.org/ec-code/2.7.10.1
constant: false
boundary condition: false
has part: P21860
has part: Q02297

140094
type: Parameter
constant: false
value: 0.0

139748
type: Species
has part: P21860
is version of: GO:0005942
has part: http://identifiers.org/ec-code/2.7.10.1
has part: P04626
has part: Q02297
constant: false
in compartment: 139677
boundary condition: false
has only substance units: false
initial concentration: 0.0
is version of: C00562
initial amount: NaN

139909
type: Reaction
kinetic law: 975507
product: 975495
reactant: 975483
fast: true
reversible: false
name: R32

975495
type: SpeciesReference
stoichiometry: 1.0
species: 139783

139783
type: Species
initial concentration: 0.0
in compartment: 139677
has part: http://identifiers.org/pubchem.compound/24755492
boundary condition: false
initial amount: NaN
has part: P31749
constant: false
is version of: C00562
has only substance units: false

975483
type: SpeciesReference
stoichiometry: 1.0
species: 139775

139826
type: Reaction
kinetic law: 974044
product: 974032
reactant: 974020
fast: true
reversible: false
name: R10

974032
type: SpeciesReference
stoichiometry: 1.0
species: 139696

139696
type: Species
is: P29353
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677

974020
type: SpeciesReference
stoichiometry: 1.0
species: 139801

139678
type: Species
is version of: P21860
is version of: http://identifiers.org/ec-code/2.7.10.1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 80.0
initial amount: NaN
in compartment: 139677

140056
type: Parameter
constant: false
value: 3.0

140076
type: Parameter
constant: false
value: 340.0

139845
type: Reaction
kinetic law: 974451
modifier: 974439
product: 974427
reactant: 974415
fast: true
reversible: false
name: R17_1

139795
type: Species
is version of: P04049
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

974427
type: SpeciesReference
stoichiometry: 1.0
species: 139780

974415
type: SpeciesReference
stoichiometry: 1.0
species: 139720

139912
type: Reaction
kinetic law: 975555
product: 975543
reactant: 975531
reactant: 975519
fast: true
reversible: false
name: R33_1

975543
type: SpeciesReference
stoichiometry: 1.0
species: 139786

975531
type: SpeciesReference
stoichiometry: 1.0
species: 139723

975519
type: SpeciesReference
stoichiometry: 1.0
species: 139783

139882
type: Reaction
kinetic law: 975135
product: 975123
reactant: 975111
fast: true
reversible: false
name: R28_4

975123
type: SpeciesReference
stoichiometry: 1.0
species: 139773

975111
type: SpeciesReference
stoichiometry: 1.0
species: 139761

139831
type: Reaction
kinetic law: 974176
modifier: 974164
product: 974152
reactant: 974140
fast: true
reversible: false
name: R13

974152
type: SpeciesReference
stoichiometry: 1.0
species: 139795

974140
type: SpeciesReference
stoichiometry: 1.0
species: 139711

139711
type: Species
is version of: P04049
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677

140062
type: Parameter
constant: false
value: 9.0

140144
type: Parameter
constant: false
value: 1.0

140176
type: Parameter
constant: false
value: 200.0

139814
type: Reaction
kinetic law: 973780
product: 973768
reactant: 973756
fast: true
reversible: false
name: R4

973768
type: SpeciesReference
stoichiometry: 1.0
species: 139690

973756
type: SpeciesReference
stoichiometry: 1.0
species: 139693

139996
type: Parameter
constant: false
value: 1.0

140107
type: Parameter
constant: false
value: 6.0

140108
type: Parameter
constant: false
value: 0.18

140126
type: Parameter
constant: false
value: 0.6

139834
type: Reaction
kinetic law: 974224
modifier: 974211
product: 974200
reactant: 974188
fast: true
reversible: false
name: R14

974200
type: SpeciesReference
stoichiometry: 1.0
species: 139711

974188
type: SpeciesReference
stoichiometry: 1.0
species: 139795

139900
type: Reaction
kinetic law: 975387
product: 975375
reactant: 975363
reactant: 975351
fast: true
reversible: false
name: R31_1

975375
type: SpeciesReference
stoichiometry: 1.0
species: 139758

975363
type: SpeciesReference
stoichiometry: 1.0
species: 139723

975351
type: SpeciesReference
stoichiometry: 1.0
species: 139775

140131
type: Parameter
constant: false
value: 1.8

139853
type: Reaction
kinetic law: 974631
modifier: 974619
product: 974607
reactant: 974595
fast: true
reversible: false
name: R19

974607
type: SpeciesReference
stoichiometry: 1.0
species: 139739

974595
type: SpeciesReference
stoichiometry: 1.0
species: 139736

139736
type: Species
is version of: P27361
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 139677

140163
type: Parameter
constant: false
value: 100.0

139935
type: Reaction
kinetic law: 975903
product: 975891
reactant: 975879
fast: true
reversible: false
name: R40

975891
type: SpeciesReference
stoichiometry: 1.0
species: 139693

975879
type: SpeciesReference
stoichiometry: 1.0
species: 139714

139714
type: Species
in compartment: 139677
initial amount: NaN
initial concentration: 0.0
has part: http://identifiers.org/ec-code/2.7.10.1
occurs in: GO:0005737
has part: P04626
constant: false
boundary condition: false
has part: Q02297
has part: P21860
has only substance units: false

140085
type: Parameter
constant: false
value: 300.0

140050
type: Parameter
constant: false
value: 1.0

140183
type: Parameter
constant: false
value: 10.0

140016
type: Parameter
constant: false
value: 10.0

140035
type: Parameter
constant: false
value: 1.0

140149
type: Parameter
constant: false
value: 20.0

140168
type: Parameter
constant: false
value: 0.0

140002
type: Parameter
constant: false
value: 30.0

140022
type: Parameter
constant: false
value: 0.005

140135
type: Parameter
constant: false
value: 30.0

140120
type: Parameter
constant: false
value: 7.0

139877
type: Reaction
kinetic law: 975015
product: 975003
reactant: 974991
reactant: 974979
fast: true
reversible: false
name: R28_1

975003
type: SpeciesReference
stoichiometry: 1.0
species: 139767

139767
type: Species
has part: http://identifiers.org/pubchem.compound/24755492
has part: P60484
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.14554E-8
initial amount: NaN
in compartment: 139677

974991
type: SpeciesReference
stoichiometry: 1.0
species: 139761

974979
type: SpeciesReference
stoichiometry: 1.0
species: 139764

140091
type: Parameter
constant: false
value: 13520.0

139805
type: Reaction
kinetic law: 973660
product: 973648
reactant: 973636
reactant: 973624
fast: true
reversible: false
name: R1

973648
type: SpeciesReference
stoichiometry: 1.0
species: 139684

973636
type: SpeciesReference
stoichiometry: 1.0
species: 139804

139804
type: Species
is version of: Q02297
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3000.0
initial amount: NaN
in compartment: 139677

973624
type: SpeciesReference
stoichiometry: 1.0
species: 139678

140117
type: Parameter
constant: false
value: 11.7

139843
type: Reaction
kinetic law: 974355
product: 974343
reactant: 974331
fast: true
reversible: false
name: R16_2

974343
type: SpeciesReference
stoichiometry: 1.0
species: 139727

139727
type: Species
has part: Q02750
has part: P63151
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

974331
type: SpeciesReference
stoichiometry: 1.0
species: 139726

139808
type: Reaction
kinetic law: 973708
product: 973696
reactant: 973684
reactant: 973672
fast: true
reversible: false
name: R2

973696
type: SpeciesReference
stoichiometry: 1.0
species: 139690

973684
type: SpeciesReference
stoichiometry: 1.0
species: 139684

973672
type: SpeciesReference
stoichiometry: 1.0
species: 139687

139687
type: Species
is version of: P04626
is version of: http://identifiers.org/ec-code/2.7.10.1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677

139880
type: Reaction
kinetic law: 975051
product: 975039
reactant: 975027
fast: true
reversible: false
name: R28_2

975039
type: SpeciesReference
stoichiometry: 1.0
species: 139770

975027
type: SpeciesReference
stoichiometry: 1.0
species: 139767

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

140041
type: Parameter
constant: false
value: 10.0

140010
type: Parameter
constant: false
value: 0.0

140174
type: Parameter
constant: false
value: 2900.0

140143
type: Parameter
constant: false
value: 2.0

139865
type: Reaction
kinetic law: 974799
product: 974787
reactant: 974775
reactant: 974763
fast: true
reversible: false
name: R23

974787
type: SpeciesReference
stoichiometry: 1.0
species: 139748

974775
type: SpeciesReference
stoichiometry: 1.0
species: 139745

139745
type: Species
is version of: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 200.0
initial amount: NaN
in compartment: 139677

974763
type: SpeciesReference
stoichiometry: 1.0
species: 139693

140007
type: Parameter
constant: false
value: 91.0

140026
type: Parameter
constant: false
value: 10.0

139947
type: Reaction
kinetic law: 976059
product: 976047
reactant: 976035
fast: true
reversible: false
name: R44

976047
type: SpeciesReference
stoichiometry: 1.0
species: 139681

139681
type: Species
has part: CHEMBL98350
has part: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

976035
type: SpeciesReference
stoichiometry: 1.0
species: 139745

140159
type: Parameter
constant: false
value: 0.003

140097
type: Parameter
constant: false
value: 900.0

140161
type: Parameter
constant: false
value: 0.6

139914
type: Reaction
kinetic law: 975639
product: 975627
product: 975615
reactant: 975603
fast: true
reversible: false
name: R33_3

975627
type: SpeciesReference
stoichiometry: 1.0
species: 139723

975615
type: SpeciesReference
stoichiometry: 1.0
species: 139775

975603
type: SpeciesReference
stoichiometry: 1.0
species: 139758

139699
type: Species
has part: P04626
initial amount: NaN
has part: P21860
initial concentration: 0.0
has only substance units: false
has part: P29353
in compartment: 139677
is version of: C00562
has part: http://identifiers.org/ec-code/2.7.10.1
constant: false
has part: Q02297
boundary condition: false

139917
type: Reaction
kinetic law: 975663
reactant: 975651
fast: true
reversible: false
name: R34

975651
type: SpeciesReference
stoichiometry: 1.0
species: 139693

140181
type: Parameter
constant: false
value: 10.0

140065
type: Parameter
constant: false
value: 12.0

140147
type: Parameter
constant: false
value: 150.0

139817
type: Reaction
kinetic law: 973828
product: 973816
reactant: 973804
reactant: 973792
fast: true
reversible: false
name: R5

973816
type: SpeciesReference
stoichiometry: 1.0
species: 139699

973804
type: SpeciesReference
stoichiometry: 1.0
species: 139696

973792
type: SpeciesReference
stoichiometry: 1.0
species: 139693

139999
type: Parameter
constant: false
value: 0.6

140129
type: Parameter
constant: false
value: 1.2

139871
type: Reaction
kinetic law: 974883
product: 974871
product: 974859
reactant: 974847
fast: true
reversible: false
name: R25

974871
type: SpeciesReference
stoichiometry: 1.0
species: 139754

974859
type: SpeciesReference
stoichiometry: 1.0
species: 139693

974847
type: SpeciesReference
stoichiometry: 1.0
species: 139777

139777
type: Species
is version of: C00562
has only substance units: false
in compartment: 139677
is version of: GO:0005942
initial amount: NaN
initial concentration: 0.0
has part: Q02297
constant: false
has part: P04626
has part: P21860
boundary condition: false

140133
type: Parameter
constant: false
value: 0.03

139856
type: Reaction
kinetic law: 974667
product: 974655
reactant: 974643
fast: true
reversible: false
name: R20

974655
type: SpeciesReference
stoichiometry: 1.0
species: 139736

974643
type: SpeciesReference
stoichiometry: 1.0
species: 139739

139938
type: Reaction
kinetic law: 975939
product: 975927
reactant: 975915
fast: true
reversible: false
name: R41

975927
type: SpeciesReference
stoichiometry: 1.0
species: 139710

975915
type: SpeciesReference
stoichiometry: 1.0
species: 139779

140115
type: Parameter
constant: false
value: 0.1

139823
type: Reaction
kinetic law: 973912
product: 973900
reactant: 973888
reactant: 973876
fast: true
reversible: false
name: R7

973900
type: SpeciesReference
stoichiometry: 1.0
species: 139706

973888
type: SpeciesReference
stoichiometry: 1.0
species: 139705

139705
type: Species
in compartment: 139677
has part: P62993
has part: Q07890
has part: Q07889
boundary condition: false
initial amount: NaN
initial concentration: 100.0
has only substance units: false
constant: false

973876
type: SpeciesReference
stoichiometry: 1.0
species: 139702

140088
type: Parameter
constant: false
value: 0.0

140053
type: Parameter
constant: false
value: 12.0

140072
type: Parameter
constant: false
value: 0.0

140186
type: Parameter
constant: false
value: 120.0

140019
type: Parameter
constant: false
value: 0.0

140038
type: Parameter
constant: false
value: 0.1

W3 CDTF: Thu Aug 18 13:13:07 BST 2011

140172
type: Parameter
constant: false
value: 0.0

139926
type: Reaction
kinetic law: 975783
product: 975771
reactant: 975759
fast: true
reversible: false
name: R37

975771
type: SpeciesReference
stoichiometry: 1.0
species: 139742

975759
type: SpeciesReference
stoichiometry: 1.0
species: 139684

139811
type: Reaction
kinetic law: 973744
product: 973732
reactant: 973720
fast: true
reversible: false
name: R3

973732
type: SpeciesReference
stoichiometry: 1.0
species: 139693

973720
type: SpeciesReference
stoichiometry: 1.0
species: 139690

140024
type: Parameter
constant: false
value: 10.0

140157
type: Parameter
constant: false
value: 0.3

140122
type: Parameter
constant: false
value: 1.0

139827
type: Reaction
kinetic law: 974092
modifier: 974080
product: 974068
reactant: 974056
fast: true
reversible: false
name: R11

974068
type: SpeciesReference
stoichiometry: 1.0
species: 139798

974056
type: SpeciesReference
stoichiometry: 1.0
species: 139709

139929
type: Reaction
kinetic law: 975831
product: 975819
reactant: 975807
reactant: 975795
fast: true
reversible: false
name: R38

975819
type: SpeciesReference
stoichiometry: 1.0
species: 139690

975807
type: SpeciesReference
stoichiometry: 1.0
species: 139742

975795
type: SpeciesReference
stoichiometry: 1.0
species: 139687

140140
type: Parameter
constant: false
value: 15.0

139932
type: Reaction
kinetic law: 975867
product: 975855
reactant: 975843
fast: true
reversible: false
name: R39

975855
type: SpeciesReference
stoichiometry: 1.0
species: 139714

975843
type: SpeciesReference
stoichiometry: 1.0
species: 139690

140044
type: Parameter
constant: false
value: 50.0

140145
type: Parameter
constant: false
value: 2.2

139868
type: Reaction
kinetic law: 974835
product: 974823
reactant: 974811
fast: true
reversible: false
name: R24

974823
type: SpeciesReference
stoichiometry: 1.0
species: 139777

974811
type: SpeciesReference
stoichiometry: 1.0
species: 139748

140029
type: Parameter
constant: false
value: 0.01

140109
type: Parameter
constant: false
value: 3.0

140127
type: Parameter
constant: false
value: 0.6

ORG:
  orgname: EMBL-EBI
n:
  given: Stuart
  family: Moodie

139920
type: Reaction
kinetic law: 975711
product: 975699
reactant: 975687
reactant: 975675
fast: true
reversible: false
name: R35

975699
type: SpeciesReference
stoichiometry: 1.0
species: 139707

975687
type: SpeciesReference
stoichiometry: 1.0
species: 139789

139789
type: Species
notes: Kinetic equations are usually written in terms of concentrations (not of mole numbers), since the reaction rates are functions of concentrations. If the same compound participates in reactions taking place in different compartments with different volumes, the effective concentration of that compound will be different depending on the volume of the corresponding compartment. Step 1 (EGF binding to EGFR) could be considered as taking place in the extracellular compartment with a given initial concentration of EGF. The concentration of EGFR in the extracellular compartment would then be calculated as the number of the receptors on the cell surface divided by the (average) volume of incubation medium per cell (V m). In step 2, association and dissociation of the receptor monomers occurs in the cell membrane. All other steps are considered as taking place in the cytosolic compartment. Therefore, the same mole number of EGFR would give rise to three EGFR concentrations (representing the different compartments). However, for computational purposes, it is more convenient to deal only with a single concentration of EGFR related to the cytoplasmic water volume (V cw) of the cell. This requires rescaling the rate constants of steps 1 and 2. For the purpose of this rescaling, the EGF concentration in the model was also related to the cytoplasmic water volume; i.e. [EGF] in the experimental medium was multiplied by the ratio Vm/V cw (see TableII). Typically, there were 107cells/ml in our experiments (see “Cell Preparation and Incubation Conditions”); therefore, Vm = 10−7 ml. Assuming the diameter of a hepatocyte of 20 μm and a cytoplasmic water volume of about 70% of total intracellular volume, Vm/Vcw = 33.3. [taken from Kholodenko 1999; http://www.jbc.org/content/274/42/30169.long] Per = 0 [without Inhibitor Pertuzumab] Per = 300000 [with Inhibitor Pertuzumab] - Stuart Moodie
is version of: CHEMBL2007641
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677

975675
type: SpeciesReference
stoichiometry: 1.0
species: 139687

140132
type: Parameter
constant: false
value: 10.0

140164
type: Parameter
constant: false
value: 10.0

139903
type: Reaction
kinetic law: 975423
product: 975411
reactant: 975399
fast: true
reversible: false
name: R31_2

975411
type: SpeciesReference
stoichiometry: 1.0
species: 139730

975399
type: SpeciesReference
stoichiometry: 1.0
species: 139758

139820
type: Reaction
kinetic law: 973864
product: 973852
reactant: 973840
fast: true
reversible: false
name: R6

973852
type: SpeciesReference
stoichiometry: 1.0
species: 139702

973840
type: SpeciesReference
stoichiometry: 1.0
species: 139699

140184
type: Parameter
constant: false
value: 10.0

140150
type: Parameter
constant: false
value: 15000.0

140169
type: Parameter
constant: false
value: 0.0

139941
type: Reaction
kinetic law: 975987
product: 975975
product: 975963
reactant: 975951
fast: true
reversible: false
name: R42

975975
type: SpeciesReference
stoichiometry: 1.0
species: 139764

975963
type: SpeciesReference
stoichiometry: 1.0
species: 139754

975951
type: SpeciesReference
stoichiometry: 1.0
species: 139710

140170
type: Parameter
constant: false
value: 0.0

139894
type: Reaction
kinetic law: 975303
product: 975291
reactant: 975279
reactant: 975267
fast: true
reversible: false
name: R29

975291
type: SpeciesReference
stoichiometry: 1.0
species: 139751

975279
type: SpeciesReference
stoichiometry: 1.0
species: 139764

975267
type: SpeciesReference
stoichiometry: 1.0
species: 139776

139776
type: Species
is version of: P31749
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677

140003
type: Parameter
constant: false
value: 65.0

140136
type: Parameter
constant: false
value: 30.0

139944
type: Reaction
kinetic law: 976023
product: 976011
reactant: 975999
fast: true
reversible: false
name: R43

976011
type: SpeciesReference
stoichiometry: 1.0
species: 139708

975999
type: SpeciesReference
stoichiometry: 1.0
species: 139761

140155
type: Parameter
constant: false
value: 45.0

140121
type: Parameter
constant: false
value: 2.1

139825
type: Reaction
kinetic law: 974008
product: 973996
product: 973984
reactant: 973972
fast: true
reversible: false
name: R9

973996
type: SpeciesReference
stoichiometry: 1.0
species: 139801

973984
type: SpeciesReference
stoichiometry: 1.0
species: 139705

973972
type: SpeciesReference
stoichiometry: 1.0
species: 139792

140118
type: Parameter
constant: false
value: 0.6

140119
type: Parameter
constant: false
value: 50.0

139844
type: Reaction
kinetic law: 974403
product: 974391
product: 974379
reactant: 974367
fast: true
reversible: false
name: R16_3

974391
type: SpeciesReference
stoichiometry: 1.0
species: 139723

974379
type: SpeciesReference
stoichiometry: 1.0
species: 139717

139717
type: Species
is version of: Q02750
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 139677

974367
type: SpeciesReference
stoichiometry: 1.0
species: 139727

140188
type: Parameter
constant: false
value: 100.0

W3 CDTF: Thu Aug 09 17:20:50 BST 2012

139881
type: Reaction
kinetic law: 975099
product: 975087
product: 975075
reactant: 975063
fast: true
reversible: false
name: R28_3

975087
type: SpeciesReference
stoichiometry: 1.0
species: 139761

975075
type: SpeciesReference
stoichiometry: 1.0
species: 139755

975063
type: SpeciesReference
stoichiometry: 1.0
species: 139770

139847
type: Reaction
kinetic law: 974535
product: 974523
reactant: 974511
fast: true
reversible: false
name: R18_2

974523
type: SpeciesReference
stoichiometry: 1.0
species: 139726

974511
type: SpeciesReference
stoichiometry: 1.0
species: 139733

140175
type: Parameter
constant: false
value: -2920.0

139995
type: Parameter
constant: false
value: 0.0

140125
type: Parameter
constant: false
value: 1.0

140047
type: Parameter
constant: false
value: 0.06

140130
type: Parameter
constant: false
value: 10.0

140079
type: Parameter
constant: false
value: 3.0

140162
type: Parameter
constant: false
value: 0.012

140182
type: Parameter
constant: false
value: 100.0

140148
type: Parameter
constant: false
value: 15000.0

140167
type: Parameter
constant: false
value: 80.0

139837
type: Reaction
kinetic law: 974272
modifier: 974259
product: 974248
reactant: 974236
fast: true
reversible: false
name: R15

974248
type: SpeciesReference
stoichiometry: 1.0
species: 139720

974236
type: SpeciesReference
stoichiometry: 1.0
species: 139717

139891
type: Reaction
kinetic law: 975255
product: 975243
reactant: 975231
fast: true
reversible: false
name: R28_7

975243
type: SpeciesReference
stoichiometry: 2.0
species: 139761

975231
type: SpeciesReference
stoichiometry: 1.0
species: 139778

139873
type: Reaction
kinetic law: 974919
product: 974907
reactant: 974895
fast: true
reversible: false
name: R26

974907
type: SpeciesReference
stoichiometry: 1.0
species: 139745

974895
type: SpeciesReference
stoichiometry: 1.0
species: 139754