BIOMD0000000419
type: SBMLModel
modified:
  W3 CDTF: Wed Jul 11 19:14:11 BST 2012
parameter: 665333
parameter: 665340
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
volume units: 678655
reaction: 665320
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name: Ratushny2012_SPF_I
created:
  W3 CDTF: Thu May 10 18:51:08 BST 2012
time units: 678679
creator:
  ORG:
    orgname: Institute for Systems Biology (ISB) and Seattle BioMed
  n:
    given: Alexander
    family: Ratushny
reaction: 665317
reaction: 665313
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occurs in: http://identifiers.org/taxonomy/4932
notes: This model is from the article: Asymmetric positive feedback loops reliably control biological responses Alexander V Ratushny, Ramsey A Saleem, Katherine Sitko, Stephen A Ramsey & John D Aitchison Mol Syst Biol. 2012 Apr 24;8:577. 22531117 , Abstract: Positive feedback is a common mechanism enabling biological systems to respond to stimuli in a switch-like manner. Such systems are often characterized by the requisite formation of a heterodimer where only one of the pair is subject to feedback. This ASymmetric Self-UpREgulation (ASSURE) motif is central to many biological systems, including cholesterol homeostasis (LXRα/RXRα), adipocyte differentiation (PPARγ/RXRα), development and differentiation (RAR/RXR), myogenesis (MyoD/E12) and cellular antiviral defense (IRF3/IRF7). To understand why this motif is so prevalent, we examined its properties in an evolutionarily conserved transcriptional regulatory network in yeast (Oaf1p/Pip2p). We demonstrate that the asymmetry in positive feedback confers a competitive advantage and allows the system to robustly increase its responsiveness while precisely tuning the response to a consistent level in the presence of varying stimuli. This study reveals evolutionary advantages for the ASSURE motif, and mechanisms for control, that are relevant to pharmacologic intervention and synthetic biology applications. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, La…
parameter: 665330
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is described by: http://identifiers.org/pubmed/22531117
parameter: 665334
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area units: area
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length unit: length
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is version of: GO:0006355
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curated: true
species: 665309
parameter: 665339

665333
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value: NaN

665340
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value: 0.1

665320
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