BIOMD0000000418
type: SBMLModel
modified:
  W3 CDTF: Wed Jul 11 19:12:54 BST 2012
compartment: 519915
parameter: 519930
parameter: 519942
rule: 519925
species: 519917
reaction: 519919
parameter: 519936
time units: 678679
rule: 519923
reaction: 519921
parameter: 519932
parameter: 519944
length unit: length
creator:
  ORG:
    orgname: Institute for Systems Biology (ISB) and Seattle BioMed
  n:
    given: Alexander
    family: Ratushny
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
parameter: 519926
parameter: 519938
is version of: GO:0006355
is: MODEL1203010000
area units: area
notes: This model is from the article: Asymmetric positive feedback loops reliably control biological responses Alexander V Ratushny, Ramsey A Saleem, Katherine Sitko, Stephen A Ramsey & John D Aitchison Mol Syst Biol. 2012 Apr 24;8:577. 22531117 , Abstract: Positive feedback is a common mechanism enabling biological systems to respond to stimuli in a switch-like manner. Such systems are often characterized by the requisite formation of a heterodimer where only one of the pair is subject to feedback. This ASymmetric Self-UpREgulation (ASSURE) motif is central to many biological systems, including cholesterol homeostasis (LXRα/RXRα), adipocyte differentiation (PPARγ/RXRα), development and differentiation (RAR/RXR), myogenesis (MyoD/E12) and cellular antiviral defense (IRF3/IRF7). To understand why this motif is so prevalent, we examined its properties in an evolutionarily conserved transcriptional regulatory network in yeast (Oaf1p/Pip2p). We demonstrate that the asymmetry in positive feedback confers a competitive advantage and allows the system to robustly increase its responsiveness while precisely tuning the response to a consistent level in the presence of varying stimuli. This study reveals evolutionary advantages for the ASSURE motif, and mechanisms for control, that are relevant to pharmacologic intervention and synthetic biology applications. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, La…
volume units: 678655
created:
  W3 CDTF: Thu May 10 18:48:43 BST 2012
curated: true
parameter: 519940
parameter: 519934
is described by: http://identifiers.org/pubmed/22531117
occurs in: http://identifiers.org/taxonomy/4932
parameter: 519928
substance units: 678703
name: Ratushny2012_SPF

519915
type: Compartment
occurs in: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0

519930
type: Parameter
constant: false
value: NaN

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type: Parameter
constant: true
value: 0.1

519917
type: Species
is version of: GO:0003675
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10.0
in compartment: 519915

519919
type: Reaction
kinetic law: 755473
product: 755461
fast: false
reversible: false

755461
type: SpeciesReference
stoichiometry: 1.0
species: 519917

519936
type: Parameter
constant: true
value: 0.1

519921
type: Reaction
kinetic law: 755497
reactant: 755485
fast: false
reversible: false

519922
type: LocalParameter
value: 0.1

755485
type: SpeciesReference
stoichiometry: 1.0
species: 519917

519932
type: Parameter
constant: false
value: NaN

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constant: true
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519926
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constant: true
value: 1.0E-5

519938
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value: 40.0

519940
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constant: true
value: 10.0

519934
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constant: true
value: 2.0

519928
type: Parameter
constant: true
value: 0.001