BIOMD0000000409
type: SBMLModel
parameter: 307136
parameter: 307146
parameter: 307142
parameter: 307132
parameter: 307117
parameter: 307113
reaction: 307053
species: 307008
parameter: 307121
parameter: 307108
is: MODEL5951818256
species: 307030
parameter: 307112
parameter: 307122
species: 307014
area units: area
species: 307026
species: 307021
rule: 307101
species: 307018
substance units: substance
parameter: 307165
parameter: 307175
rule: 307093
parameter: 307171
species: 307020
parameter: 307156
parameter: 307166
species: 307004
compartment: 307002
parameter: 307170
reaction: 307062
parameter: 307151
rule: 307105
reaction: 307063
parameter: 307147
reaction: 307038
parameter: 307143
reaction: 307046
reaction: 307056
rule: 307096
reaction: 307064
parameter: 307150
parameter: 307138
parameter: 307148
is version of: GO:0000278
reaction: 307037
reaction: 307047
parameter: 307115
parameter: 307123
parameter: 307133
curated: true
rule: 307100
reaction: 307032
parameter: 307118
species: 307011
species: 307023
species: 307003
parameter: 307120
is version of: CCO:P0000038
reaction: 307041
parameter: 307167
parameter: 307168
species: 307006
length unit: length
species: 307013
rule: 307103
species: 307025
parameter: 307172
parameter: 307157
parameter: 307153
species: 307029
rule: 307095
parameter: 307161
volume units: volume
reaction: 307048
reaction: 307058
species: 307016
parameter: 307152

307136
type: Parameter
constant: true
value: 0.4
name: kp

307146
type: Parameter
constant: true
value: 0.01
name: kdpolo

307142
type: Parameter
constant: true
value: 1.0
name: Net1T

307132
type: Parameter
constant: true
value: 1.0
name: ldsecurin

307117
type: Parameter
constant: true
value: 2.0
name: kadcdc20

307113
type: Parameter
constant: true
value: 2.0
name: kaadclb2

307053
type: Reaction
reversible: true
modifier: 514055
product: 514019
fast: false
reactant: 514007
is: SBO:0000216
name: Net1Cdc14 phosphorylation
kinetic law: 514067
modifier: 514043
modifier: 514031
is version of: GO:0016310

307004
type: Species
initial concentration: 0.997
in compartment: 307002
name: Clb2
is version of: P24869
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000252
constant: false

307002
type: Compartment
is version of: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment

514019
type: SpeciesReference
stoichiometry: 1.0
species: 307030

307030
type: Species
is: SBO:0000297
name: Net1P
is version of: C00562
constant: false
initial concentration: NaN
in compartment: 307002
has only substance units: false
is version of: P47035
initial amount: NaN
boundary condition: true

514007
type: SpeciesReference
stoichiometry: 1.0
species: 307018

307018
type: Species
has only substance units: false
initial concentration: 0.485
initial amount: NaN
constant: false
name: Net1Cdc14
has part: P47035
is: SBO:0000297
in compartment: 307002
boundary condition: false
has part: Q00684

307016
type: Species
name: Net1
initial amount: NaN
initial concentration: 0.098
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: false
is version of: P47035
in compartment: 307002

307028
type: Species
initial concentration: 8.0E-6
name: MEN
boundary condition: false
in compartment: 307002
is: SBO:0000297
constant: false
has only substance units: false
initial amount: NaN
has part: P27636
has part: P38987

307008
type: Species
name: Cdh1
initial amount: NaN
is: SBO:0000252
initial concentration: 3.8E-5
in compartment: 307002
constant: false
has only substance units: false
is version of: P53197
boundary condition: false

307121
type: Parameter
constant: true
value: 1.0
name: kapcdh

307108
type: Parameter
constant: false
value: NaN
name: Cdk activity

307112
type: Parameter
constant: true
value: 0.2
name: kadclb2

307122
type: Parameter
constant: true
value: 0.0015
name: Jcdh

307014
type: Species
boundary condition: true
has only substance units: false
name: separase
initial amount: NaN
in compartment: 307002
is: SBO:0000252
constant: false
initial concentration: NaN
is version of: Q03018

307026
type: Species
initial amount: NaN
name: inactive Cdc15
is: SBO:0000252
is version of: P27636
has only substance units: false
initial concentration: NaN
boundary condition: true
in compartment: 307002
constant: false

307021
type: Species
is version of: P32562
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
in compartment: 307002
name: inactive Polo
constant: false
has only substance units: false

307165
type: Parameter
constant: true
value: 0.2
name: kaicdc15

307175
type: Parameter
constant: true
value: 0.0
name: Inh

307171
type: Parameter
constant: true
value: 0.1
name: kpp

307020
type: Species
has only substance units: false
initial amount: NaN
name: Polo
initial concentration: 0.945
in compartment: 307002
is version of: P32562
is: SBO:0000252
boundary condition: false
constant: false

307156
type: Parameter
constant: true
value: 0.1
name: kitem

307166
type: Parameter
constant: true
value: 0.2
name: Jcdc15

307170
type: Parameter
constant: true
value: 1.0
name: Cdc15T

307062
type: Reaction
kinetic law: 514408
modifier: 514396
product: 514384
name: v24
is: SBO:0000181
fast: false
is version of: GO:0006464
reversible: true
reactant: 514372

307029
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is version of: Q00362
name: PP2A
has only substance units: false
is: SBO:0000252
boundary condition: true
in compartment: 307002

514384
type: SpeciesReference
stoichiometry: 1.0
species: 307024

307024
type: Species
boundary condition: true
initial amount: NaN
name: inactive Tem1
constant: false
initial concentration: NaN
has only substance units: false
in compartment: 307002
is: SBO:0000252
is version of: P38987

514372
type: SpeciesReference
stoichiometry: 1.0
species: 307023

307023
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: Tem1
boundary condition: false
constant: false
in compartment: 307002
initial concentration: 0.00389
is version of: P38987

307151
type: Parameter
constant: true
value: 0.1
name: kipolo

307063
type: Reaction
is: SBO:0000181
fast: false
reversible: true
modifier: 514444
product: 514432
kinetic law: 514456
name: v25
reactant: 514420
is version of: GO:0006464

307031
type: Species
is: SBO:0000252
is version of: Q00684
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: Cdc14
initial concentration: NaN
in compartment: 307002

514432
type: SpeciesReference
stoichiometry: 1.0
species: 307025

307025
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: Cdc15
boundary condition: false
in compartment: 307002
has only substance units: false
is version of: P27636
initial concentration: 0.0257

514420
type: SpeciesReference
stoichiometry: 1.0
species: 307026

307147
type: Parameter
constant: true
value: 0.25
name: kadpolo

307038
type: Reaction
kinetic law: 513428
product: 513416
reactant: 513404
is version of: GO:0006464
is: SBO:0000181
fast: false
reversible: true
name: v6

513416
type: SpeciesReference
stoichiometry: 1.0
species: 307009

307009
type: Species
initial amount: NaN
in compartment: 307002
is: SBO:0000252
name: inactive Cdh1
constant: false
is version of: P53197
initial concentration: NaN
boundary condition: true
has only substance units: false

513404
type: SpeciesReference
stoichiometry: 1.0
species: 307008

307143
type: Parameter
constant: true
value: 0.5
name: Cdc14T

307046
type: Reaction
fast: false
reactant: 513692
name: securinseparase securindegradation
reversible: true
is version of: GO:0043241
product: 513704
modifier: 513716
kinetic law: 513729
is: SBO:0000179

513692
type: SpeciesReference
stoichiometry: 1.0
species: 307015

307015
type: Species
name: securin:separase
initial amount: NaN
has part: Q03018
has part: P40316
constant: false
initial concentration: 0.248
is: SBO:0000297
boundary condition: false
in compartment: 307002
has only substance units: false

513704
type: SpeciesReference
stoichiometry: 1.0
species: 307014

307006
type: Species
in compartment: 307002
name: Cdc20
initial amount: NaN
is: SBO:0000252
constant: false
is version of: P26309
initial concentration: 0.0
boundary condition: false
has only substance units: false

307056
type: Reaction
name: v19
reactant: 514140
fast: false
kinetic law: 514176
is version of: GO:0030163
is: SBO:0000179
reactant: 514128
modifier: 514164
product: 514152
reversible: true

514140
type: SpeciesReference
stoichiometry: 1.0
species: 307021

514128
type: SpeciesReference
stoichiometry: 1.0
species: 307019

307019
type: Species
boundary condition: false
constant: false
is: SBO:0000252
has only substance units: false
name: PoloT
in compartment: 307002
initial amount: NaN
is version of: P32562
initial concentration: 0.99

514152
type: SpeciesReference
stoichiometry: 1.0
species: 307005

307005
type: Species
is: SBO:0000291
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 307002
name: degr

307064
type: Reaction
kinetic law: 514493
product: 514481
reactant: 514469
is version of: GO:0006464
is: SBO:0000181
fast: false
reversible: true
name: v26

514481
type: SpeciesReference
stoichiometry: 1.0
species: 307026

514469
type: SpeciesReference
stoichiometry: 1.0
species: 307025

307150
type: Parameter
constant: true
value: 0.5
name: kaapolo

307138
type: Parameter
constant: true
value: 0.2
name: Jnet

307148
type: Parameter
constant: true
value: 0.0
name: kapolo

307037
type: Reaction
product: 513367
name: v5
fast: false
is version of: GO:0006464
modifier: 513379
is: SBO:0000181
kinetic law: 513392
reactant: 513355
reversible: true

513367
type: SpeciesReference
stoichiometry: 1.0
species: 307008

513355
type: SpeciesReference
stoichiometry: 1.0
species: 307009

307047
type: Reaction
kinetic law: 513766
product: 513753
reactant: 513741
is version of: GO:0043241
is: SBO:0000179
fast: false
reversible: true
name: securin:separase separase degradation

513753
type: SpeciesReference
stoichiometry: 1.0
species: 307011

307011
type: Species
has only substance units: false
is: SBO:0000252
is version of: P40316
in compartment: 307002
initial concentration: NaN
constant: false
name: securin
initial amount: NaN
boundary condition: true

513741
type: SpeciesReference
stoichiometry: 1.0
species: 307015

307115
type: Parameter
constant: true
value: 0.015
name: kscdc20

307123
type: Parameter
constant: true
value: 1.0
name: Cdh1T

307133
type: Parameter
constant: true
value: 0.1
name: kad

307032
type: Reaction
kinetic law: 513197
product: 513185
reactant: 513173
is version of: GO:0006412
is: SBO:0000393
fast: false
reversible: true
name: v1

513185
type: SpeciesReference
stoichiometry: 1.0
species: 307004

513173
type: SpeciesReference
stoichiometry: 1.0
species: 307003

307003
type: Species
is: SBO:0000291
name: AA
constant: true
is version of: CHEBI:33704
in compartment: 307002
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN

307118
type: Parameter
constant: true
value: 0.01
name: kdcdh

307120
type: Parameter
constant: true
value: 1.0
name: kadcdh

307041
type: Reaction
reactant: 513500
modifier: 513524
reversible: true
fast: false
name: v8
product: 513512
kinetic law: 513536
is version of: GO:0030163
reactant: 513488
is: SBO:0000179

513500
type: SpeciesReference
stoichiometry: 1.0
species: 307011

513512
type: SpeciesReference
stoichiometry: 1.0
species: 307005

513488
type: SpeciesReference
stoichiometry: 1.0
species: 307010

307010
type: Species
in compartment: 307002
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: securinT
boundary condition: false
initial concentration: 0.6
is version of: P40316
constant: false

307167
type: Parameter
constant: true
value: 10.0
name: lamen

307168
type: Parameter
constant: true
value: 0.1
name: ldmen

307013
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 0.25
in compartment: 307002
name: separaseT
is version of: Q03018
boundary condition: false
is: SBO:0000252
constant: false

307172
type: Parameter
constant: true
value: 20.0
name: ki

307157
type: Parameter
constant: true
value: 1.0
name: kaitem

307153
type: Parameter
constant: true
value: 0.0
name: katem

307161
type: Parameter
constant: true
value: 0.02
name: kacdc15

307048
type: Reaction
modifier: 513814
reversible: true
modifier: 513826
fast: false
product: 513790
reactant: 513778
name: Net1P dephosphorylation
is: SBO:0000330
kinetic law: 513838
is version of: GO:0016311
modifier: 513802

513790
type: SpeciesReference
stoichiometry: 1.0
species: 307016

513778
type: SpeciesReference
stoichiometry: 1.0
species: 307030

307058
type: Reaction
kinetic law: 514262
product: 514250
reactant: 514238
is version of: GO:0006464
is: SBO:0000181
fast: false
reversible: true
name: v21

514250
type: SpeciesReference
stoichiometry: 1.0
species: 307021

514238
type: SpeciesReference
stoichiometry: 1.0
species: 307020

307152
type: Parameter
constant: true
value: 0.25
name: Jpolo

307162
type: Parameter
constant: true
value: 0.5
name: kaacdc15

307066
type: Reaction
fast: false
is: SBO:0000393
reactant: 514505
modifier: 514541
name: v27
reversible: true
kinetic law: 514553
modifier: 514529
is version of: GO:0006412
product: 514517

514505
type: SpeciesReference
stoichiometry: 1.0
species: 307003

514517
type: SpeciesReference
stoichiometry: 1.0
species: 307028

307039
type: Reaction
fast: false
product: 513452
is: SBO:0000393
name: v7
kinetic law: 513476
product: 513464
reactant: 513440
is version of: GO:0006412
reversible: true

513452
type: SpeciesReference
stoichiometry: 1.0
species: 307010

513464
type: SpeciesReference
stoichiometry: 1.0
species: 307011

513440
type: SpeciesReference
stoichiometry: 1.0
species: 307003

307049
type: Reaction
is version of: GO:0016310
fast: false
reactant: 513850
reversible: true
product: 513862
is: SBO:0000216
modifier: 513874
modifier: 513886
name: Net1 phosphorylation
modifier: 513898
kinetic law: 513910

513850
type: SpeciesReference
stoichiometry: 1.0
species: 307016

513862
type: SpeciesReference
stoichiometry: 1.0
species: 307030

307057
type: Reaction
product: 514200
reactant: 514188
modifier: 514213
kinetic law: 514225
is version of: GO:0006464
is: SBO:0000181
fast: false
reversible: true
name: v20

514200
type: SpeciesReference
stoichiometry: 1.0
species: 307020

514188
type: SpeciesReference
stoichiometry: 1.0
species: 307021

307067
type: Reaction
kinetic law: 514589
product: 514577
reactant: 514565
is version of: GO:0030163
is: SBO:0000179
fast: false
reversible: true
name: v28

514577
type: SpeciesReference
stoichiometry: 1.0
species: 307005

514565
type: SpeciesReference
stoichiometry: 1.0
species: 307028

307125
type: Parameter
constant: true
value: 0.03
name: kssecurin

307135
type: Parameter
constant: true
value: 0.45
name: kd

307131
type: Parameter
constant: true
value: 500.0
name: lasecurin

307034
type: Reaction
kinetic law: 513294
product: 513281
reactant: 513269
is version of: GO:0006412
is: SBO:0000393
fast: false
reversible: true
name: v3

513281
type: SpeciesReference
stoichiometry: 1.0
species: 307006

513269
type: SpeciesReference
stoichiometry: 1.0
species: 307003

307052
type: Reaction
kinetic law: 513995
product: 513983
reactant: 513971
is version of: GO:0043241
is: SBO:0000180
fast: false
reversible: true
name: v16

513983
type: SpeciesReference
stoichiometry: 1.0
species: 307016

513971
type: SpeciesReference
stoichiometry: 1.0
species: 307018

307042
type: Reaction
product: 513572
reactant: 513548
fast: false
is version of: GO:0006412
kinetic law: 513584
is: SBO:0000393
reversible: true
name: v9
product: 513560

513572
type: SpeciesReference
stoichiometry: 1.0
species: 307014

513548
type: SpeciesReference
stoichiometry: 1.0
species: 307003

513560
type: SpeciesReference
stoichiometry: 1.0
species: 307013

307116
type: Parameter
constant: true
value: 0.05
name: kdcdc20

307126
type: Parameter
constant: true
value: 0.05
name: kdsecurin

307033
type: Reaction
is: SBO:0000179
fast: false
modifier: 513245
reversible: true
name: v2
reactant: 513209
kinetic law: 513257
is version of: GO:0030163
product: 513221
modifier: 513233

513209
type: SpeciesReference
stoichiometry: 1.0
species: 307004

513221
type: SpeciesReference
stoichiometry: 1.0
species: 307005

307130
type: Parameter
constant: true
value: 0.004
name: kdseparase

307140
type: Parameter
constant: true
value: 500.0
name: lanet

307043
type: Reaction
reactant: 513608
product: 513620
is: SBO:0000179
kinetic law: 513632
name: v10
reversible: true
fast: false
reactant: 513596
is version of: GO:0030163

513608
type: SpeciesReference
stoichiometry: 1.0
species: 307014

513620
type: SpeciesReference
stoichiometry: 1.0
species: 307005

513596
type: SpeciesReference
stoichiometry: 1.0
species: 307013

307111
type: Parameter
constant: true
value: 0.03
name: kdclb2

W3 CDTF: Thu Aug 20 17:15:09 BST 2009

307110
type: Parameter
constant: true
value: 0.03
name: ksclb2

307155
type: Parameter
constant: true
value: 0.5
name: kaatem

307163
type: Parameter
constant: true
value: 0.0
name: kicdc15

307173
type: Parameter
constant: true
value: 1.0
name: PP2AT

307158
type: Parameter
constant: true
value: 0.005
name: Jtem1

307068
type: Reaction
is: SBO:0000179
name: Tem1 degradation in MEN
is version of: GO:0030163
reversible: true
kinetic law: 514637
reactant: 514601
modifier: 514613
modifier: 514625
fast: false

514601
type: SpeciesReference
stoichiometry: 1.0
species: 307028

307160
type: Parameter
constant: true
value: 1.0
name: Tem1T

307059
type: Reaction
fast: false
reversible: true
is version of: GO:0030163
is: SBO:0000179
modifier: 514299
name: v22
reactant: 514274
product: 514287
kinetic law: 514311

514274
type: SpeciesReference
stoichiometry: 1.0
species: 307020

514287
type: SpeciesReference
stoichiometry: 1.0
species: 307005

307069
type: Reaction
modifier: 514661
fast: false
kinetic law: 514685
reversible: true
is: SBO:0000179
modifier: 514673
reactant: 514649
is version of: GO:0030163
name: Cdc15 degradation in MEN

514649
type: SpeciesReference
stoichiometry: 1.0
species: 307028

307127
type: Parameter
constant: true
value: 2.0
name: kadsecurin

307137
type: Parameter
constant: true
value: 2.0
name: kap

W3 CDTF: Mon Jul 16 13:01:33 BST 2012

307061
type: Reaction
reversible: true
fast: false
product: 514335
reactant: 514323
is: SBO:0000181
name: v23
is version of: GO:0006464
kinetic law: 514360
modifier: 514347

514335
type: SpeciesReference
stoichiometry: 1.0
species: 307023

514323
type: SpeciesReference
stoichiometry: 1.0
species: 307024

307051
type: Reaction
is: SBO:0000526
fast: false
name: v15
modifier: 513947
kinetic law: 513959
reactant: 513923
product: 513935
is version of: GO:0006461
reversible: true

513923
type: SpeciesReference
stoichiometry: 1.0
species: 307016

513935
type: SpeciesReference
stoichiometry: 1.0
species: 307018

307145
type: Parameter
constant: true
value: 0.01
name: kspolo

307036
type: Reaction
is version of: GO:0030163
fast: false
reversible: true
name: v4
is: SBO:0000179
reactant: 513306
modifier: 513330
product: 513318
kinetic law: 513343

513306
type: SpeciesReference
stoichiometry: 1.0
species: 307006

513318
type: SpeciesReference
stoichiometry: 1.0
species: 307005

307054
type: Reaction
reactant: 514079
product: 514103
product: 514091
is version of: GO:0006412
fast: false
name: v18
kinetic law: 514115
is: SBO:0000393
reversible: true

514079
type: SpeciesReference
stoichiometry: 1.0
species: 307003

514103
type: SpeciesReference
stoichiometry: 1.0
species: 307021

514091
type: SpeciesReference
stoichiometry: 1.0
species: 307019

307141
type: Parameter
constant: true
value: 1.0
name: ldnet

307044
type: Reaction
fast: false
reactant: 513656
kinetic law: 513680
is: SBO:0000526
is version of: GO:0006461
reversible: true
product: 513668
name: v11
reactant: 513644

513656
type: SpeciesReference
stoichiometry: 1.0
species: 307014

513668
type: SpeciesReference
stoichiometry: 1.0
species: 307015

513644
type: SpeciesReference
stoichiometry: 1.0
species: 307011

307128
type: Parameter
constant: true
value: 0.001
name: ksseparase

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah