BIOMD0000000407
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species: 22
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species: 8
species: 28
reaction: 289355
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reaction: 289396
reaction: 289388
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species: 20
length unit: length
reaction: 289461
reaction: 289359
species: 27
species: 36
species: 46
species: 5
species: 30
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reaction: 289379
reaction: 289452
species: 41
reaction: 289403
reaction: 289358
species: 24
reaction: 289450
reaction: 289409
reaction: 289423
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reaction: 289407
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reaction: 289443
reaction: 289376
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reaction: 289440
reaction: 289432
reaction: 289467
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reaction: 289362
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reaction: 289436
reaction: 289382
reaction: 289431
reaction: 289456
reaction: 289415
reaction: 289351
reaction: 289462
species: 35
reaction: 289386
reaction: 289400
reaction: 289435
occurs in: http://identifiers.org/taxonomy/9606
reaction: 289371
reaction: 289419
reaction: 289455
reaction: 289404
curated: true
species: 19
species: 32
species: 13
reaction: 289391
species: 23
reaction: 289439
reaction: 289350
reaction: 289375
reaction: 289459
reaction: 289370
reaction: 289395

12
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449992
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289177
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450040
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2
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289178
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22
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450112
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450100
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289392
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modifier: 451413
product: 451401
reactant: 451389
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fast: false
reversible: false
name: IKK activation by TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2

289525
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units: 450088
value: 0.03125
name: IKK activation by TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2 ka

21
type: Species
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451401
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23
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451389
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450148
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450136
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39
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8
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name: FADD

28
type: Species
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289355
type: Reaction
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product: 450295
is: SBO:0000357
fast: false
reversible: true
name: TRAF2 turnover

289481
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units: 450004
value: 1.0E-4
name: TRAF2 turnover kd

450016
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289479
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value: 3.3056E-5
name: TRAF2 turnover ka

450076
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450064
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450295
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7
type: Species
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29
type: Species
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substance units: 449980
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289179
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constant: true
units: 450028
size: 1.056
spatial dimensions: 3.0

289396
type: Reaction
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product: 451485
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fast: false
reversible: true
name: FLIP turnover

289532
type: LocalParameter
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units: 450004
value: 1.0E-4
name: FLIP turnover kd

289531
type: LocalParameter
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units: 450052
value: 2.24902E-6
name: FLIP turnover ka

451485
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species: 15

15
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boundary condition: false
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initial amount: 0.0320472
is: SBO:0000252
name: FLIP

289388
type: Reaction
kinetic law: 451268
product: 451256
reactant: 451244
reactant: 451232
is: SBO:0000526
fast: false
reversible: false
name: Procaspase-8 recruitment to TNFR Complex2~FLIP

289521
type: LocalParameter
is: SBO:0000009
units: 450088
value: 0.3125
name: Procaspase-8 recruitment to TNFR Complex2~FLIP ka

451256
type: SpeciesReference
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species: 20

20
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451244
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species: 38

38
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name: pCasp8

451232
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16
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43
type: Species
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name: Casp6
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substance units: 449980
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initial amount: 0.0
constant: false

289461
type: Reaction
kinetic law: 453001
modifier: 452989
reactant: 452977
is: SBO:0000179
fast: false
reversible: false
name: XIAP degradation due to Caspase-3

289612
type: LocalParameter
is: SBO:0000356
units: 450088
value: 1.875
name: XIAP degradation due to Caspase-3 ka

42
type: Species
substance units: 449980
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name: Casp3
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452977
type: SpeciesReference
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37
type: Species
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289359
type: Reaction
kinetic law: 450379
reactant: 450367
is: SBO:0000179
fast: false
reversible: false
name: TNF:TNFR:TRADD degradation

289486
type: LocalParameter
is: SBO:0000356
units: 450004
value: 0.02352
name: TNF:TNFR:TRADD degradation ka

450367
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9
type: Species
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name: TNF:TNFR:TRADD
initial amount: 0.0

27
type: Species
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boundary condition: false
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initial concentration: NaN
constant: false
name: IkBa:NFkB
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36
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boundary condition: false
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substance units: 449980
name: BAR
is version of: Q9NZS9

46
type: Species
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substance units: 449980
is: SBO:0000252
initial amount: 1.66667
name: PARP
is version of: P09874
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initial concentration: NaN
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5
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boundary condition: false
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is version of: Q13546
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name: RIP
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initial concentration: NaN

30
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substance units: 449980
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initial concentration: NaN
boundary condition: false
constant: false
has only substance units: true
is version of: P25963
name: IkBa_N
initial amount: 0.0013839

289379
type: Reaction
kinetic law: 450929
product: 450917
reactant: 450905
is: SBO:0000395
fast: false
reversible: false
name: Receptor internalisation step4

289510
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.1135
name: Receptor internalisation step4 ka

450917
type: SpeciesReference
stoichiometry: 1.0
species: 14

14
type: Species
constant: false
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boundary condition: false
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initial concentration: NaN
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name: TNFRC2
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450905
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species: 13

13
type: Species
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289452
type: Reaction
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reactant: 452737
is: SBO:0000357
fast: false
reversible: true
name: PARP turnover

289602
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units: 450052
value: 9.64506E-6
name: PARP turnover kd

289601
type: LocalParameter
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units: 450004
value: 5.78704E-6
name: PARP turnover ka

452737
type: SpeciesReference
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species: 46

41
type: Species
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substance units: 449980
is: SBO:0000252
boundary condition: false
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constant: false
initial amount: 0.0

289403
type: Reaction
kinetic law: 451617
reactant: 451605
is: SBO:0000179
fast: false
reversible: false
name: nuclear NF-kappaB degradation

289541
type: LocalParameter
is: SBO:0000356
units: 450004
value: 1.0E-4
name: nuclear NF-kappaB degradation ka

451605
type: SpeciesReference
stoichiometry: 1.0
species: 29

289358
type: Reaction
kinetic law: 450355
reactant: 450343
is: SBO:0000179
fast: false
reversible: false
name: TNF~TNFR degradation

289485
type: LocalParameter
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units: 450004
value: 5.6E-5
name: TNF~TNFR degradation ka

450343
type: SpeciesReference
stoichiometry: 1.0
species: 3

3
type: Species
is: SBO:0000297
in compartment: 289178
has only substance units: true
name: TNF:TNFR_E
substance units: 449980
boundary condition: false
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24
type: Species
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initial amount: 0.104434
boundary condition: false
name: A20
substance units: 449980
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constant: false
is: SBO:0000252

289450
type: Reaction
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reactant: 452713
is: SBO:0000179
fast: false
reversible: false
name: BAR~Caspase-8 complex degradation

289599
type: LocalParameter
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units: 450004
value: 5.78704E-5
name: BAR~Caspase-8 complex degradation ka

452713
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species: 44

44
type: Species
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boundary condition: false
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initial concentration: NaN
substance units: 449980
name: BAR:Casp8
in compartment: 289177

289409
type: Reaction
kinetic law: 451713
reactant: 451701
is: SBO:0000179
fast: false
reversible: false
name: nuclear IkappaBalpha~NF-kappaB complex degradation

289548
type: LocalParameter
is: SBO:0000356
units: 450004
value: 1.0E-4
name: nuclear IkappaBalpha~NF-kappaB complex degradation ka

451701
type: SpeciesReference
stoichiometry: 1.0
species: 31

31
type: Species
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constant: false
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initial amount: 9.00189E-5
name: IkBa:NFkB_N
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substance units: 449980
in compartment: 289179

289423
type: Reaction
kinetic law: 452134
modifier: 452122
product: 452110
is: SBO:0000183
fast: false
reversible: false
name: IkappaBalpha-mRNA transcription

289565
type: LocalParameter
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units: 450004
value: 3.0303E-5
name: IkappaBalpha-mRNA transcription ka

452110
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species: 33

33
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is: SBO:0000278
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initial amount: 5.31517E-5
substance units: 449980
constant: false
boundary condition: false
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name: IkBa_mRNA

289407
type: Reaction
kinetic law: 451689
reactant: 451677
is: SBO:0000179
fast: false
reversible: false
name: free nuclear IkappaBalpha degradation

289546
type: LocalParameter
is: SBO:0000356
units: 450004
value: 1.0E-4
name: free nuclear IkappaBalpha degradation ka

451677
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species: 30

289443
type: Reaction
kinetic law: 452605
reactant: 452593
is: SBO:0000179
fast: false
reversible: false
name: Caspase-8 degradation

289591
type: LocalParameter
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units: 450004
value: 5.78704E-5
name: Caspase-8 degradation ka

452593
type: SpeciesReference
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species: 41

289376
type: Reaction
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kinetic law: 450840
product: 450801
product: 450827
is: SBO:0000395
reversible: false
name: Receptor internalisation step2
product: 450814
reactant: 450788

289507
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.001135
name: Receptor internalisation step2 ka

450801
type: SpeciesReference
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species: 5

450827
type: SpeciesReference
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species: 12

450814
type: SpeciesReference
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species: 7

450788
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species: 11

11
type: Species
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initial concentration: NaN
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name: TNFRCint1
substance units: 449980
constant: false
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289367
type: Reaction
kinetic law: 450523
reactant: 450511
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~Procaspase-8~Procaspase-8 degradation

289496
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~Procaspase-8~Procaspase-8 degradation ka

450511
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species: 19

19
type: Species
initial concentration: NaN
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substance units: 449980
name: TNFRC2:pCasp8:pCasp8
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constant: false
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is version of: P01375
boundary condition: false

289440
type: Reaction
kinetic law: 452557
product: 452545
is: SBO:0000357
fast: false
reversible: true
name: Procaspase-3 turnover

289587
type: LocalParameter
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units: 450004
value: 6.17284E-5
name: Procaspase-3 turnover kd

289585
type: LocalParameter
is: SBO:0000009
units: 450052
value: 4.93827E-5
name: Procaspase-3 turnover ka

452545
type: SpeciesReference
stoichiometry: 1.0
species: 39

289432
type: Reaction
kinetic law: 452365
modifier: 452353
product: 452341
is: SBO:0000184
fast: false
reversible: false
name: A20 translation

289575
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.0151515
name: A20 translation ka

32
type: Species
constant: false
is version of: ENST00000237289
name: A20_mRNA
in compartment: 289179
is: SBO:0000278
boundary condition: false
has only substance units: true
initial concentration: NaN
substance units: 449980
initial amount: 5.56657E-5

452341
type: SpeciesReference
stoichiometry: 1.0
species: 24

289467
type: Reaction
kinetic law: 453157
modifier: 453145
product: 453133
reactant: 453121
is: SBO:0000178
fast: false
reversible: false
name: PARP cleavage as Casp3 substrate

289618
type: LocalParameter
is: SBO:0000356
units: 450088
value: 0.1875
name: PARP cleavage as Casp3 substrate ka

453133
type: SpeciesReference
stoichiometry: 1.0
species: 47

47
type: Species
initial amount: 0.0
boundary condition: false
has only substance units: true
constant: false
is version of: P09874
initial concentration: NaN
name: cPARP
is: SBO:0000252
in compartment: 289177
substance units: 449980

453121
type: SpeciesReference
stoichiometry: 1.0
species: 46

289362
type: Reaction
kinetic law: 450427
reactant: 450415
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2 degradation

289489
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2 degradation ka

450415
type: SpeciesReference
stoichiometry: 1.0
species: 14

289411
type: Reaction
kinetic law: 451761
reactant: 451749
is: SBO:0000179
fast: false
reversible: false
name: A20-mRNA degradation

289551
type: LocalParameter
is: SBO:0000356
units: 450004
value: 4.70498E-4
name: A20-mRNA degradation ka

451749
type: SpeciesReference
stoichiometry: 1.0
species: 32

17
type: Species
in compartment: 289177
initial amount: 0.0
is version of: Q13158
constant: false
boundary condition: false
name: TNFRC2:pCasp8
is version of: Q14790
has only substance units: true
is version of: P19438
is version of: P01375
substance units: 449980
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is: SBO:0000297
initial concentration: NaN

289436
type: Reaction
kinetic law: 452473
modifier: 452461
product: 452449
is: SBO:0000183
fast: false
reversible: false
name: FLIP-mRNA transcription

289579
type: LocalParameter
is: SBO:0000009
units: 450004
value: 3.33333E-5
name: FLIP-mRNA transcription ka

452449
type: SpeciesReference
stoichiometry: 1.0
species: 35

35
type: Species
is: SBO:0000278
name: FLIP_mRNA
initial concentration: NaN
initial amount: 1.39056E-4
in compartment: 289179
is version of: ENST00000309955
constant: false
substance units: 449980
boundary condition: false
has only substance units: true

289382
type: Reaction
kinetic law: 451027
product: 451014
reactant: 451001
reactant: 450989
is: SBO:0000526
fast: false
reversible: false
name: FLIP recruitment to TNFR Complex2~FLIP

289513
type: LocalParameter
is: SBO:0000009
units: 450088
value: 0.3125
name: FLIP recruitment to TNFR Complex2~FLIP ka

451014
type: SpeciesReference
stoichiometry: 1.0
species: 18

18
type: Species
initial amount: 0.0
is version of: Q13158
is version of: O15519
is version of: P01375
boundary condition: false
substance units: 449980
is version of: Q15628
initial concentration: NaN
is version of: P19438
constant: false
has only substance units: true
in compartment: 289177
name: TNFRC2:FLIP:FLIP
is: SBO:0000297

451001
type: SpeciesReference
stoichiometry: 1.0
species: 16

450989
type: SpeciesReference
stoichiometry: 1.0
species: 15

289431
type: Reaction
kinetic law: 452329
modifier: 452317
product: 452305
is: SBO:0000183
fast: false
reversible: false
name: A20-mRNA transcription

289573
type: LocalParameter
is: SBO:0000009
units: 450004
value: 3.78788E-5
name: A20-mRNA transcription ka

452305
type: SpeciesReference
stoichiometry: 1.0
species: 32

289456
type: Reaction
kinetic law: 452869
modifier: 452857
product: 452845
reactant: 452833
is: SBO:0000170
fast: false
reversible: false
name: Caspase-6 activation

289606
type: LocalParameter
is: SBO:0000363
units: 450088
value: 0.009375
name: Caspase-6 activation ka

452845
type: SpeciesReference
stoichiometry: 1.0
species: 43

452833
type: SpeciesReference
stoichiometry: 1.0
species: 40

40
type: Species
is version of: P55212
initial concentration: NaN
is: SBO:0000252
initial amount: 0.064
boundary condition: false
has only substance units: true
name: pCasp6
constant: false
substance units: 449980
in compartment: 289177

289415
type: Reaction
kinetic law: 451857
modifier: 451845
product: 451833
reactant: 451821
is: SBO:0000170
fast: false
reversible: false
name: IKK activation by TNFR Complex1

289555
type: LocalParameter
is: SBO:0000363
units: 450088
value: 93.75
name: IKK activation by TNFR Complex1 ka

10
type: Species
is version of: Q12933
is: SBO:0000297
initial concentration: NaN
boundary condition: false
initial amount: 0.0
is version of: Q13546
has only substance units: true
in compartment: 289177
is version of: P19438
is version of: P01375
is version of: Q15628
name: TNFRC1
substance units: 449980
constant: false

451833
type: SpeciesReference
stoichiometry: 1.0
species: 23

451821
type: SpeciesReference
stoichiometry: 1.0
species: 22

289351
type: Reaction
kinetic law: 450234
reactant: 450222
is: SBO:0000179
fast: false
reversible: false
name: TNFR degradation

289472
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR degradation ka

450222
type: SpeciesReference
stoichiometry: 1.0
species: 1

1
type: Species
has only substance units: true
boundary condition: false
initial amount: 0.005
substance units: 449980
constant: false
is: SBO:0000252
is version of: P19438
name: TNFR_E
initial concentration: NaN
in compartment: 289178

289462
type: Reaction
kinetic law: 453037
product: 453025
reactant: 453013
is: SBO:0000180
fast: false
reversible: false
name: XIAP~Caspase-3 complex breakup

289613
type: LocalParameter
is: SBO:0000282
units: 450004
value: 5.0E-5
name: XIAP~Caspase-3 complex breakup ka

453025
type: SpeciesReference
stoichiometry: 1.0
species: 37

453013
type: SpeciesReference
stoichiometry: 1.0
species: 45

45
type: Species
substance units: 449980
initial amount: 0.0
constant: false
is version of: P42574
boundary condition: false
initial concentration: NaN
has only substance units: true
is: SBO:0000297
name: XIAP:Casp3
in compartment: 289177
is version of: P98170

289386
type: Reaction
kinetic law: 451171
product: 451159
product: 451147
reactant: 451135
is: SBO:0000180
fast: false
reversible: false
name: Caspase-8 activation by TNFR Complex2

289518
type: LocalParameter
is: SBO:0000363
units: 450004
value: 0.45
name: Caspase-8 activation by TNFR Complex2 ka

451159
type: SpeciesReference
stoichiometry: 1.0
species: 41

451147
type: SpeciesReference
stoichiometry: 1.0
species: 14

451135
type: SpeciesReference
stoichiometry: 1.0
species: 19

289400
type: Reaction
kinetic law: 451569
reactant: 451557
is: SBO:0000179
fast: false
reversible: false
name: IKK* degradation

289538
type: LocalParameter
is: SBO:0000356
units: 450004
value: 1.0E-4
name: IKK* degradation ka

451557
type: SpeciesReference
stoichiometry: 1.0
species: 23

289435
type: Reaction
kinetic law: 452437
modifier: 452425
product: 452413
is: SBO:0000184
fast: false
reversible: false
name: XIAP translation

289578
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.0506061
name: XIAP translation ka

34
type: Species
substance units: 449980
is: SBO:0000278
initial amount: 2.19646E-4
name: XIAP_mRNA
in compartment: 289179
boundary condition: false
is version of: ENST00000371199
has only substance units: true
initial concentration: NaN
constant: false

452413
type: SpeciesReference
stoichiometry: 1.0
species: 37

289371
type: Reaction
kinetic law: 450620
product: 450608
reactant: 450596
reactant: 450584
is: SBO:0000526
fast: false
reversible: true
name: TNF~TNFR binding and release

289501
type: LocalParameter
is: SBO:0000337
units: 450004
value: 6.60377E-5
name: TNF~TNFR binding and release kd

289500
type: LocalParameter
is: SBO:0000337
units: 450088
value: 0.00953471
name: TNF~TNFR binding and release ka

450608
type: SpeciesReference
stoichiometry: 1.0
species: 3

450596
type: SpeciesReference
stoichiometry: 1.0
species: 2

450584
type: SpeciesReference
stoichiometry: 1.0
species: 1

289419
type: Reaction
kinetic law: 452002
product: 451990
reactant: 451978
reactant: 451966
is: SBO:0000526
fast: false
reversible: false
name: IkappaBalpha NF-kappaB association

289560
type: LocalParameter
is: SBO:0000337
units: 450088
value: 1.25
name: IkappaBalpha NF-kappaB association ka

451990
type: SpeciesReference
stoichiometry: 1.0
species: 27

451978
type: SpeciesReference
stoichiometry: 1.0
species: 26

26
type: Species
constant: false
name: IkBa
boundary condition: false
is: SBO:0000252
initial concentration: NaN
initial amount: 0.00101518
is version of: P25963
substance units: 449980
has only substance units: true
in compartment: 289177

451966
type: SpeciesReference
stoichiometry: 1.0
species: 25

25
type: Species
boundary condition: false
initial concentration: NaN
is version of: P19838
constant: false
has only substance units: true
is: SBO:0000252
name: NFkB
substance units: 449980
in compartment: 289177
initial amount: 1.15365E-4

289455
type: Reaction
kinetic law: 452821
modifier: 452809
product: 452797
reactant: 452785
is: SBO:0000170
fast: false
reversible: false
name: Caspase-3 activation

289605
type: LocalParameter
is: SBO:0000363
units: 450088
value: 0.015625
name: Caspase-3 activation ka

452797
type: SpeciesReference
stoichiometry: 1.0
species: 42

452785
type: SpeciesReference
stoichiometry: 1.0
species: 39

289404
type: Reaction
kinetic law: 451641
reactant: 451629
is: SBO:0000179
fast: false
reversible: false
name: IkappaBalpha-mRNA degradation

289543
type: LocalParameter
is: SBO:0000356
units: 450004
value: 3.94201E-4
name: IkappaBalpha-mRNA degradation ka

451629
type: SpeciesReference
stoichiometry: 1.0
species: 33

289391
type: Reaction
product: 451365
name: RIP~TRAF2 recruitment at TNFR Complex2~FLIP~Procaspase-8
reversible: false
reactant: 451329
is: SBO:0000526
fast: false
kinetic law: 451377
reactant: 451353
reactant: 451341

451365
type: SpeciesReference
stoichiometry: 1.0
species: 21

451329
type: SpeciesReference
stoichiometry: 1.0
species: 5

289524
type: LocalParameter
is: SBO:0000009
units: 450124
value: 0.00976562
name: RIP~TRAF2 recruitment at TNFR Complex2~FLIP~Procaspase-8 ka

451353
type: SpeciesReference
stoichiometry: 1.0
species: 20

451341
type: SpeciesReference
stoichiometry: 1.0
species: 7

289439
type: Reaction
kinetic law: 452533
product: 452521
is: SBO:0000357
fast: false
reversible: true
name: Procaspase-8 turnover

289583
type: LocalParameter
is: SBO:0000009
units: 450004
value: 6.17284E-5
name: Procaspase-8 turnover kd

289582
type: LocalParameter
is: SBO:0000009
units: 450052
value: 1.97531E-4
name: Procaspase-8 turnover ka

452521
type: SpeciesReference
stoichiometry: 1.0
species: 38

289350
type: Reaction
kinetic law: 450210
product: 450198
is: SBO:0000393
fast: false
reversible: false
name: TNFR production

289471
type: LocalParameter
is: SBO:0000009
units: 450052
value: 2.8E-7
name: TNFR production ka

450198
type: SpeciesReference
stoichiometry: 1.0
species: 4

4
type: Species
is version of: P19438
substance units: 449980
initial amount: 2.8E-4
is: SBO:0000252
has only substance units: true
constant: false
boundary condition: false
in compartment: 289177
name: TNFR
initial concentration: NaN

289375
type: Reaction
kinetic law: 450775
product: 450762
reactant: 450748
is: SBO:0000395
fast: false
reversible: false
name: Receptor internalisation step1

289506
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.001135
name: Receptor internalisation step1 ka

450762
type: SpeciesReference
stoichiometry: 1.0
species: 11

450748
type: SpeciesReference
stoichiometry: 1.0
species: 10

289459
type: Reaction
kinetic law: 452965
product: 452953
reactant: 452941
reactant: 452929
is: SBO:0000526
fast: false
reversible: true
name: XIAP~Caspase-3 complex formation

289610
type: LocalParameter
is: SBO:0000337
units: 450004
value: 0.001
name: XIAP~Caspase-3 complex formation kd

289609
type: LocalParameter
is: SBO:0000337
units: 450088
value: 0.625
name: XIAP~Caspase-3 complex formation ka

452953
type: SpeciesReference
stoichiometry: 1.0
species: 45

452941
type: SpeciesReference
stoichiometry: 1.0
species: 42

452929
type: SpeciesReference
stoichiometry: 1.0
species: 37

289370
type: Reaction
kinetic law: 450572
reactant: 450560
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2 degradation

289499
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2 degradation ka

450560
type: SpeciesReference
stoichiometry: 1.0
species: 21

289395
type: Reaction
kinetic law: 451473
product: 451461
is: SBO:0000357
fast: false
reversible: true
name: NF-kappaB turnover

289530
type: LocalParameter
is: SBO:0000009
units: 450004
value: 1.0E-4
name: NF-kappaB turnover kd

289529
type: LocalParameter
is: SBO:0000009
units: 450052
value: 1.6E-6
name: NF-kappaB turnover ka

451461
type: SpeciesReference
stoichiometry: 1.0
species: 25

289368
type: Reaction
kinetic law: 450547
reactant: 450535
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP~Procaspase-8 degradation

289497
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP~Procaspase-8 degradation ka

450535
type: SpeciesReference
stoichiometry: 1.0
species: 20

289390
type: Reaction
kinetic law: 451317
product: 451305
product: 451293
reactant: 451280
is: SBO:0000180
fast: false
reversible: false
name: Caspase-8 activation by TNFR Complex2~FLIP~Procaspase-8

289522
type: LocalParameter
is: SBO:0000363
units: 450004
value: 0.3
name: Caspase-8 activation by TNFR Complex2~FLIP~Procaspase-8 ka

451305
type: SpeciesReference
stoichiometry: 1.0
species: 41

451293
type: SpeciesReference
stoichiometry: 1.0
species: 14

451280
type: SpeciesReference
stoichiometry: 1.0
species: 20

289428
type: Reaction
kinetic law: 452257
product: 452245
reactant: 452233
reactant: 452221
is: SBO:0000526
fast: false
reversible: false
name: IkappaBalpha binding NF-kappaB in nucleus

289570
type: LocalParameter
is: SBO:0000337
units: 450088
value: 1.4348
name: IkappaBalpha binding NF-kappaB in nucleus ka

452245
type: SpeciesReference
stoichiometry: 1.0
species: 31

452233
type: SpeciesReference
stoichiometry: 1.0
species: 30

452221
type: SpeciesReference
stoichiometry: 1.0
species: 29

289374
type: Reaction
reactant: 450695
kinetic law: 450735
reactant: 450708
reversible: false
product: 450721
name: TNFR Complex1 building
fast: false
reactant: 450682
is: SBO:0000526

450695
type: SpeciesReference
stoichiometry: 1.0
species: 7

289504
type: LocalParameter
is: SBO:0000337
units: 450124
value: 0.0976562
name: TNFR Complex1 building ka

450708
type: SpeciesReference
stoichiometry: 1.0
species: 9

450721
type: SpeciesReference
stoichiometry: 1.0
species: 10

450682
type: SpeciesReference
stoichiometry: 1.0
species: 5

6
type: Species
name: TRADD
is version of: Q15628
initial concentration: NaN
is: SBO:0000252
has only substance units: true
boundary condition: false
substance units: 449980
initial amount: 0.29344
in compartment: 289177
constant: false

289464
type: Reaction
kinetic law: 453073
modifier: 453061
reactant: 453049
is: SBO:0000169
fast: false
reversible: false
name: negative feedback loop Caspase-3 on TNFR Complex1

289615
type: LocalParameter
is: SBO:0000261
units: 450088
value: 0.15625
name: negative feedback loop Caspase-3 on TNFR Complex1 ka

453049
type: SpeciesReference
stoichiometry: 1.0
species: 5

289366
type: Reaction
kinetic law: 450499
reactant: 450487
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~Procaspase-8 degradation

289494
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~Procaspase-8 degradation ka

450487
type: SpeciesReference
stoichiometry: 1.0
species: 17

289448
type: Reaction
kinetic law: 452677
reactant: 452665
is: SBO:0000179
fast: false
reversible: false
name: XIAP~Caspase-3 complex degradation

289595
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: XIAP~Caspase-3 complex degradation ka

452665
type: SpeciesReference
stoichiometry: 1.0
species: 45

289394
type: Reaction
kinetic law: 451449
product: 451437
is: SBO:0000357
fast: false
reversible: true
name: IKK turnover

289528
type: LocalParameter
is: SBO:0000009
units: 450004
value: 1.0E-4
name: IKK turnover kd

289527
type: LocalParameter
is: SBO:0000009
units: 450052
value: 6.4E-5
name: IKK turnover ka

451437
type: SpeciesReference
stoichiometry: 1.0
species: 22

W3 CDTF: Thu Mar 08 11:11:11 GMT 2012

289468
type: Reaction
kinetic law: 453205
product: 453193
reactant: 453181
reactant: 453169
is: SBO:0000526
fast: false
reversible: true
name: BAR~Caspase-8 complex formation

289620
type: LocalParameter
is: SBO:0000337
units: 450004
value: 0.001
name: BAR~Caspase-8 complex formation kd

289619
type: LocalParameter
is: SBO:0000337
units: 450088
value: 0.520833
name: BAR~Caspase-8 complex formation ka

453193
type: SpeciesReference
stoichiometry: 1.0
species: 44

453181
type: SpeciesReference
stoichiometry: 1.0
species: 41

453169
type: SpeciesReference
stoichiometry: 1.0
species: 36

289363
type: Reaction
kinetic law: 450451
reactant: 450439
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP degradation

289491
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP degradation ka

450439
type: SpeciesReference
stoichiometry: 1.0
species: 16

289383
type: Reaction
kinetic law: 451075
product: 451063
reactant: 451051
reactant: 451039
is: SBO:0000526
fast: false
reversible: false
name: Procaspase-8 recruitment to TNFR Complex2

289515
type: LocalParameter
is: SBO:0000009
units: 450088
value: 0.03125
name: Procaspase-8 recruitment to TNFR Complex2 ka

451063
type: SpeciesReference
stoichiometry: 1.0
species: 17

451051
type: SpeciesReference
stoichiometry: 1.0
species: 38

451039
type: SpeciesReference
stoichiometry: 1.0
species: 14

289356
type: Reaction
kinetic law: 450331
product: 450319
is: SBO:0000357
fast: false
reversible: true
name: FADD turnover

289483
type: LocalParameter
is: SBO:0000009
units: 450004
value: 1.0E-4
name: FADD turnover kd

289482
type: LocalParameter
is: SBO:0000009
units: 450052
value: 3.0944E-5
name: FADD turnover ka

450319
type: SpeciesReference
stoichiometry: 1.0
species: 8

289421
type: Reaction
reactant: 452014
name: release and degradation of bound IkappaBalpha
fast: false
reversible: false
kinetic law: 452062
modifier: 452050
product: 452038
is: SBO:0000179
product: 452026

452014
type: SpeciesReference
stoichiometry: 1.0
species: 27

289562
type: LocalParameter
is: SBO:0000356
units: 450088
value: 0.104167
name: release and degradation of bound IkappaBalpha ka

452038
type: SpeciesReference
stoichiometry: 1.0
species: 28

452026
type: SpeciesReference
stoichiometry: 1.0
species: 25

289354
type: Reaction
kinetic law: 450283
product: 450271
is: SBO:0000357
fast: false
reversible: true
name: TRADD turnover

289477
type: LocalParameter
is: SBO:0000009
units: 450004
value: 1.0E-4
name: TRADD turnover kd

289476
type: LocalParameter
is: SBO:0000009
units: 450052
value: 2.9344E-5
name: TRADD turnover ka

450271
type: SpeciesReference
stoichiometry: 1.0
species: 6

289348
type: Reaction
kinetic law: 450185
product: 450173
reactant: 450161
is: SBO:0000185
fast: false
reversible: false
name: TNFR transport into membrane

289469
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.001
name: TNFR transport into membrane ka

450173
type: SpeciesReference
stoichiometry: 1.0
species: 1

450161
type: SpeciesReference
stoichiometry: 1.0
species: 4

289425
type: Reaction
kinetic law: 452172
modifier: 452159
product: 452146
is: SBO:0000184
fast: false
reversible: false
name: IkappaBalpha translation

289566
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.0606061
name: IkappaBalpha translation ka

452146
type: SpeciesReference
stoichiometry: 1.0
species: 26

289399
type: Reaction
kinetic law: 451545
product: 451533
is: SBO:0000357
fast: false
reversible: true
name: A20 turnover

289537
type: LocalParameter
is: SBO:0000009
units: 450004
value: 1.0E-4
name: A20 turnover kd

289536
type: LocalParameter
is: SBO:0000009
units: 450052
value: 9.6E-6
name: A20 turnover ka

451533
type: SpeciesReference
stoichiometry: 1.0
species: 24

289410
type: Reaction
kinetic law: 451737
reactant: 451725
is: SBO:0000179
fast: false
reversible: false
name: P-IkappaBa degradation

289549
type: LocalParameter
is: SBO:0000356
units: 450004
value: 0.0115517
name: P-IkappaBa degradation ka

451725
type: SpeciesReference
stoichiometry: 1.0
species: 28

289445
type: Reaction
kinetic law: 452629
reactant: 452617
is: SBO:0000179
fast: false
reversible: false
name: Caspase-3 degradation

289592
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: Caspase-3 degradation ka

452617
type: SpeciesReference
stoichiometry: 1.0
species: 42

289378
type: Reaction
kinetic law: 450892
product: 450879
reactant: 450866
reactant: 450853
is: SBO:0000395
fast: false
reversible: false
name: Receptor internalisation step3

289509
type: LocalParameter
is: SBO:0000009
units: 450124
value: 0.0118534
name: Receptor internalisation step3 ka

450879
type: SpeciesReference
stoichiometry: 1.0
species: 13

450866
type: SpeciesReference
stoichiometry: 1.0
species: 12

450853
type: SpeciesReference
stoichiometry: 2.0
species: 8

289429
type: Reaction
kinetic law: 452293
product: 452281
reactant: 452269
is: SBO:0000185
fast: false
reversible: false
name: IkappaBalpha_NF-kappaB N-C export

289572
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.0151515
name: IkappaBalpha_NF-kappaB N-C export ka

452281
type: SpeciesReference
stoichiometry: 1.0
species: 27

452269
type: SpeciesReference
stoichiometry: 1.0
species: 31

289465
type: Reaction
kinetic law: 453109
modifier: 453097
reactant: 453085
is: SBO:0000179
fast: false
reversible: false
name: FLIP degradation by Caspase-3

289616
type: LocalParameter
is: SBO:0000356
units: 450088
value: 0.15625
name: FLIP degradation by Caspase-3 ka

453085
type: SpeciesReference
stoichiometry: 1.0
species: 15

289414
type: Reaction
kinetic law: 451809
reactant: 451797
is: SBO:0000179
fast: false
reversible: false
name: FLIP-mRNA degradation

289554
type: LocalParameter
is: SBO:0000356
units: 450004
value: 1.65744E-4
name: FLIP-mRNA degradation ka

451797
type: SpeciesReference
stoichiometry: 1.0
species: 35

289398
type: Reaction
kinetic law: 451521
product: 451509
is: SBO:0000357
fast: false
reversible: true
name: XIAP turnover

289535
type: LocalParameter
is: SBO:0000009
units: 450004
value: 1.0E-4
name: XIAP turnover kd

289534
type: LocalParameter
is: SBO:0000009
units: 450052
value: 7.72256E-4
name: XIAP turnover ka

451509
type: SpeciesReference
stoichiometry: 1.0
species: 37

289449
type: Reaction
kinetic law: 452701
product: 452689
is: SBO:0000357
fast: false
reversible: true
name: BAR turnover

289598
type: LocalParameter
is: SBO:0000009
units: 450004
value: 5.78704E-6
name: BAR turnover kd

289597
type: LocalParameter
is: SBO:0000009
units: 450052
value: 1.66603E-6
name: BAR turnover ka

452689
type: SpeciesReference
stoichiometry: 1.0
species: 36

289360
type: Reaction
kinetic law: 450403
reactant: 450391
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex1 degradation

289488
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex1 degradation ka

450391
type: SpeciesReference
stoichiometry: 1.0
species: 10

289380
type: Reaction
kinetic law: 450977
product: 450965
reactant: 450953
reactant: 450941
is: SBO:0000526
fast: false
reversible: false
name: FLIP recruitment to TNFR Complex2

289512
type: LocalParameter
is: SBO:0000009
units: 450088
value: 0.3125
name: FLIP recruitment to TNFR Complex2 ka

450965
type: SpeciesReference
stoichiometry: 1.0
species: 16

450953
type: SpeciesReference
stoichiometry: 1.0
species: 15

450941
type: SpeciesReference
stoichiometry: 1.0
species: 14

289418
type: Reaction
product: 451929
is: SBO:0000169
reactant: 451905
fast: false
reversible: false
product: 451917
kinetic law: 451953
name: TNFR Complex1 inactivation by A20
modifier: 451941

451929
type: SpeciesReference
stoichiometry: 1.0
species: 9

451905
type: SpeciesReference
stoichiometry: 1.0
species: 10

451917
type: SpeciesReference
stoichiometry: 1.0
species: 7

289558
type: LocalParameter
is: SBO:0000349
units: 450088
value: 0.00625
name: TNFR Complex1 inactivation by A20 ka

289364
type: Reaction
kinetic law: 450475
reactant: 450463
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP~FLIP degradation

289492
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP~FLIP degradation ka

450463
type: SpeciesReference
stoichiometry: 1.0
species: 18

289413
type: Reaction
kinetic law: 451785
reactant: 451773
is: SBO:0000179
fast: false
reversible: false
name: XIAP-mRNA degradation

289552
type: LocalParameter
is: SBO:0000356
units: 450004
value: 1.04931E-4
name: XIAP-mRNA degradation ka

451773
type: SpeciesReference
stoichiometry: 1.0
species: 34

289387
type: Reaction
kinetic law: 451220
product: 451208
reactant: 451195
reactant: 451183
is: SBO:0000526
fast: false
reversible: false
name: FLIP recruitment to TNFR Complex2~Procaspase-8

289519
type: LocalParameter
is: SBO:0000009
units: 450088
value: 0.3125
name: FLIP recruitment to TNFR Complex2~Procaspase-8 ka

451208
type: SpeciesReference
stoichiometry: 1.0
species: 20

451195
type: SpeciesReference
stoichiometry: 1.0
species: 17

451183
type: SpeciesReference
stoichiometry: 1.0
species: 15

289384
type: Reaction
kinetic law: 451123
product: 451111
reactant: 451099
reactant: 451087
is: SBO:0000526
fast: false
reversible: false
name: Procaspase-8 recruitment to TNFR Complex2~Procaspase-8

289516
type: LocalParameter
is: SBO:0000009
units: 450088
value: 0.03125
name: Procaspase-8 recruitment to TNFR Complex2~Procaspase-8 ka

451111
type: SpeciesReference
stoichiometry: 1.0
species: 19

451099
type: SpeciesReference
stoichiometry: 1.0
species: 38

451087
type: SpeciesReference
stoichiometry: 1.0
species: 17

289433
type: Reaction
kinetic law: 452401
modifier: 452389
product: 452377
is: SBO:0000183
fast: false
reversible: false
name: XIAP-mRNA transcription

289576
type: LocalParameter
is: SBO:0000009
units: 450004
value: 3.33333E-5
name: XIAP-mRNA transcription ka

452377
type: SpeciesReference
stoichiometry: 1.0
species: 34

289458
type: Reaction
kinetic law: 452917
modifier: 452905
product: 452893
reactant: 452881
is: SBO:0000170
fast: false
reversible: false
name: Caspase-8 activation

289608
type: LocalParameter
is: SBO:0000363
units: 450088
value: 0.0015625
name: Caspase-8 activation ka

452893
type: SpeciesReference
stoichiometry: 1.0
species: 41

452881
type: SpeciesReference
stoichiometry: 1.0
species: 38

289417
type: Reaction
kinetic law: 451893
product: 451881
reactant: 451869
is: SBO:0000169
fast: false
reversible: false
name: IKK* inactivation

289557
type: LocalParameter
is: SBO:0000349
units: 450004
value: 0.1
name: IKK* inactivation ka

451881
type: SpeciesReference
stoichiometry: 1.0
species: 22

451869
type: SpeciesReference
stoichiometry: 1.0
species: 23

289453
type: Reaction
kinetic law: 452773
reactant: 452761
is: SBO:0000179
fast: false
reversible: false
name: CPARP degradation

289603
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.78704E-6
name: CPARP degradation ka

452761
type: SpeciesReference
stoichiometry: 1.0
species: 47

289402
type: Reaction
kinetic law: 451593
reactant: 451581
is: SBO:0000179
fast: false
reversible: false
name: IkappaBalpha~NF-kappaB complex degradation

289540
type: LocalParameter
is: SBO:0000356
units: 450004
value: 1.0E-4
name: IkappaBalpha~NF-kappaB complex degradation ka

451581
type: SpeciesReference
stoichiometry: 1.0
species: 27

289437
type: Reaction
kinetic law: 452509
modifier: 452497
product: 452485
is: SBO:0000184
fast: false
reversible: false
name: FLIP translation

289581
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.00687273
name: FLIP translation ka

452485
type: SpeciesReference
stoichiometry: 1.0
species: 15

289422
type: Reaction
kinetic law: 452098
product: 452086
reactant: 452074
is: SBO:0000185
fast: false
reversible: false
name: NF-kappaB nuclear translocation

289563
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.0125
name: NF-kappaB nuclear translocation ka

452086
type: SpeciesReference
stoichiometry: 1.0
species: 29

452074
type: SpeciesReference
stoichiometry: 1.0
species: 25

289406
type: Reaction
kinetic law: 451665
reactant: 451653
is: SBO:0000179
fast: false
reversible: false
name: IkappaBalpha degradation

289545
type: LocalParameter
is: SBO:0000356
units: 450004
value: 0.00154022
name: IkappaBalpha degradation ka

451653
type: SpeciesReference
stoichiometry: 1.0
species: 26

289352
type: Reaction
kinetic law: 450259
product: 450246
is: SBO:0000357
fast: false
reversible: true
name: RIP turnover

289475
type: LocalParameter
is: SBO:0000009
units: 450004
value: 1.0E-4
name: RIP turnover kd

289474
type: LocalParameter
is: SBO:0000009
units: 450052
value: 2.0256E-5
name: RIP turnover ka

450246
type: SpeciesReference
stoichiometry: 1.0
species: 5

289442
type: Reaction
kinetic law: 452581
product: 452569
is: SBO:0000357
fast: false
reversible: true
name: Procaspase-6 turnover

289589
type: LocalParameter
is: SBO:0000009
units: 450004
value: 6.17284E-5
name: Procaspase-6 turnover kd

289588
type: LocalParameter
is: SBO:0000009
units: 450052
value: 3.95062E-6
name: Procaspase-6 turnover ka

452569
type: SpeciesReference
stoichiometry: 1.0
species: 40

289426
type: Reaction
kinetic law: 452209
product: 452196
reactant: 452184
is: SBO:0000526
fast: false
reversible: true
name: IkappaBalpha nuclear translocation

289569
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.00257576
name: IkappaBalpha nuclear translocation kd

289568
type: LocalParameter
is: SBO:0000009
units: 450004
value: 0.005
name: IkappaBalpha nuclear translocation ka

452196
type: SpeciesReference
stoichiometry: 1.0
species: 30

452184
type: SpeciesReference
stoichiometry: 1.0
species: 26

289372
type: Reaction
kinetic law: 450669
product: 450657
reactant: 450645
reactant: 450633
is: SBO:0000526
fast: false
reversible: false
name: TNF~TNFR~TRADD building

289503
type: LocalParameter
is: SBO:0000337
units: 450088
value: 0.00427827
name: TNF~TNFR~TRADD building ka

450657
type: SpeciesReference
stoichiometry: 1.0
species: 9

450645
type: SpeciesReference
stoichiometry: 1.0
species: 6

450633
type: SpeciesReference
stoichiometry: 1.0
species: 3

289446
type: Reaction
kinetic law: 452653
reactant: 452641
is: SBO:0000179
fast: false
reversible: false
name: Caspase-6 degradation

289594
type: LocalParameter
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: Caspase-6 degradation ka

452641
type: SpeciesReference
stoichiometry: 1.0
species: 43

W3 CDTF: Mon Jan 16 14:48:14 GMT 2012

ORG:
  orgname: Otto-von-Guericke-Universität Magdeburg
n:
  given: Monica
  family: Schliemann

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah