BIOMD0000000404
type: SBMLModel
reaction: COPASI59
reaction: COPASI74
reaction: COPASI42
name: Autophosphorylation
species: COPASI31
reaction: COPASI47
is: MODEL6929313478
rule: 557279
reaction: COPASI71
species: COPASI15
function def: COPASI77
species: COPASI28
species: COPASI27
parameter: COPASI36
name: function_4_motor_r3
name: function_4_motor_r2
parameter: COPASI32
species: COPASI20
length unit: length
function def: COPASI76
reaction: COPASI63
reaction: COPASI68
occurs in: http://identifiers.org/taxonomy/562
species: COPASI6
reaction: COPASI51
species: COPASI5
reaction: COPASI56
reaction: COPASI60
reaction: COPASI65
species: COPASI3
species: COPASI11
reaction: COPASI44
function def: 557284
reaction: COPASI53
reaction: COPASI49
species: COPASI24
species: COPASI23
reaction: COPASI73
species: COPASI17
curated: true
species: COPASI16
reaction: COPASI70
reaction: COPASI75
species: COPASI29
parameter: COPASI38
name: function_4_motor_r4
parameter: COPASI34
species: COPASI22
species: COPASI21
time units: metaid_0000322
name: ModAutophosphorylation
species: COPASI19
event: COPASI39
parameter: COPASI35
name: Bray1993_chemotaxis
species: COPASI30
function def: 557280
function def: 557281
area units: 498119
species: COPASI8
species: COPASI7
reaction: COPASI58
reaction: COPASI62
reaction: COPASI67
species: COPASI13
notes: This version of the model is very close to the version described in the paper with one exception: the binding of aspartate to the various receptor complexes, as well as the formation of the different complexes are modeled using chemical kinetics (mass action law), rather than instant equilibrium. The qualitative behaviour of the model is unchanged. Note that in order to quantitatively replicate the figure 8b, and in particular to have a basal bias of 0.7, we have to change the rate constant of the aspartate-triggered dephosphorylation of CheY from 59000 to 70000. The peaks have then slightly different values. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2012 The BioModels.net Team. For more information see the terms of use . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: COPASI12
reaction: COPASI41
reaction: COPASI46
reaction: COPASI50
reaction: COPASI55
reaction: COPASI64
species: COPASI26
species: COPASI25
reaction: COPASI43
species: COPASI9
compartment: COPASI2
reaction: COPASI48
species: COPASI18

COPASI59
type: Reaction
name: Tasp+W<->Tasp_W
kinetic law: 382651
reactant: 382627
reversible: true
product: 382639
is version of: GO:0006461
is: SBO:0000177
fast: false
reactant: 382615

557211
type: LocalParameter
value: 1.0
name: k2

557210
type: LocalParameter
value: 100000.0
name: k1

382627
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI8
type: Species
is: P0A964
initial concentration: 2.89E-6
is: SBO:0000245
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: W
in compartment: COPASI2

COPASI2
type: Compartment
is version of: GO:0005623
is: SBO:0000290
constant: true
size: 1.41E-15
spatial dimensions: 3.0
name: cell

382639
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

COPASI10
type: Species
has part: P07017
in compartment: COPASI2
boundary condition: false
is: SBO:0000253
constant: false
has part: P0A964
has only substance units: false
name: Tasp_W
initial concentration: 0.0
initial amount: NaN
has part: CHEBI:35391

382615
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

COPASI6
type: Species
in compartment: COPASI2
name: Tasp
constant: false
initial concentration: 0.0
has part: P07017
has part: CHEBI:35391
has only substance units: false
initial amount: NaN
is: SBO:0000253
boundary condition: false

COPASI74
type: Reaction
kinetic law: 383372
is version of: GO:0070335
is: SBO:0000177
name: TW+asp <-> Tasp_W
reversible: true
fast: false
reactant: 383347
product: 383359
reactant: 383335

557236
type: LocalParameter
value: 1.0
name: k2

557235
type: LocalParameter
value: 1000000.0
name: k1

383347
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

COPASI3
type: Species
constant: false
name: asp
is: CHEBI:35391
initial amount: NaN
in compartment: COPASI2
is: SBO:0000247
has only substance units: false
initial concentration: 0.0
boundary condition: true

383359
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

383335
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

COPASI9
type: Species
has only substance units: false
has part: P07017
name: TW
boundary condition: false
is: SBO:0000253
initial concentration: 5.91E-7
has part: P0A964
initial amount: NaN
constant: false
in compartment: COPASI2

COPASI42
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
is version of: GO:0006468
is: SBO:0000216
reversible: false
product: 381796
name: TWA+A->TWA+Ap
modifier: 381808
kinetic law: 381820
reactant: 381784

381796
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

COPASI20
type: Species
is version of: P07363
has only substance units: false
has property: MOD:00696
is: SBO:0000245
initial concentration: 3.48E-8
initial amount: NaN
name: Ap
in compartment: COPASI2
boundary condition: false
constant: false

COPASI16
type: Species
is: SBO:0000253
has part: P0A964
has part: P07017
initial concentration: 8.47E-7
in compartment: COPASI2
constant: false
has part: P07363
has only substance units: false
boundary condition: false
name: TWA
initial amount: NaN

557182
type: LocalParameter
value: 75000.0
name: kcat

381784
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

COPASI19
type: Species
boundary condition: false
is: SBO:0000245
initial concentration: 3.0E-6
in compartment: COPASI2
initial amount: NaN
name: A
constant: false
has only substance units: false
is version of: P07363

COPASI31
type: Species
is: SBO:0000247
initial concentration: 0.1
boundary condition: true
is: CHEBI:15422
in compartment: COPASI2
constant: true
has only substance units: false
name: ATP
initial amount: NaN

COPASI47
type: Reaction
reactant: 382037
is: SBO:0000330
product: 382049
kinetic law: 382061
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0006470
name: Yp->Y
reversible: false
fast: false

382037
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

COPASI25
type: Species
has only substance units: false
is version of: P0AE67
name: Yp
initial concentration: 7.0E-9
constant: false
boundary condition: false
initial amount: NaN
in compartment: COPASI2
has property: MOD:00696

382049
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

COPASI24
type: Species
has only substance units: false
boundary condition: false
in compartment: COPASI2
is version of: P0AE67
constant: false
initial concentration: 9.9E-6
is: SBO:0000245
initial amount: NaN
name: Y

557189
type: LocalParameter
value: 0.037
name: k1

COPASI71
type: Reaction
reactant: 383203
kinetic law: 383227
name: MYpYp+Yp<->MYpYpYp
is: SBO:0000177
fast: false
reactant: 383191
is version of: GO:0006461
product: 383215
reversible: true

383203
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

383191
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

COPASI28
type: Species
name: MYpYp
in compartment: COPASI2
boundary condition: false
initial amount: NaN
initial concentration: 2.99E-10
is: SBO:0000253
has part: P06974
has part: P0AE67
constant: false
has only substance units: false

383215
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

COPASI29
type: Species
initial amount: NaN
in compartment: COPASI2
boundary condition: false
is: SBO:0000253
has part: P06974
constant: false
name: MYpYpYp
initial concentration: 3.78E-10
has only substance units: false
has part: P0AE67

COPASI15
type: Species
constant: false
has part: P0A964
has only substance units: false
initial amount: NaN
initial concentration: 6.78E-7
is: SBO:0000253
in compartment: COPASI2
has part: P07363
boundary condition: false
name: WA

COPASI27
type: Species
constant: false
has only substance units: false
initial amount: NaN
has part: P06974
has part: P0AE67
is: SBO:0000253
initial concentration: 7.77E-10
in compartment: COPASI2
boundary condition: false
name: MYp

COPASI36
type: Parameter
constant: true
value: 1.0E-7
name: asp_pulse

COPASI32
type: Parameter
constant: true
value: 0.14
name: alpha

COPASI63
type: Reaction
kinetic law: 382843
reactant: 382819
is version of: GO:0006461
fast: false
product: 382831
reversible: true
is: SBO:0000177
reactant: 382807
name: Tasp+WA<->Tasp_WA

557219
type: LocalParameter
value: 1.0
name: k2

557218
type: LocalParameter
value: 400000.0
name: k1

382819
type: SpeciesReference
stoichiometry: 1.0
species: COPASI15

382831
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

COPASI17
type: Species
in compartment: COPASI2
has part: P07363
name: Tasp_WA
initial concentration: 0.0
boundary condition: false
is: SBO:0000253
has part: P07017
has part: P0A964
constant: false
has part: CHEBI:35391
has only substance units: false
initial amount: NaN

382807
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

COPASI68
type: Reaction
is version of: GO:0006461
fast: false
reactant: 383047
reversible: true
is: SBO:0000177
product: 383071
reactant: 383059
kinetic law: 383083
name: Tni+WA<->Tni_WA

383047
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

COPASI7
type: Species
has part: P07017
in compartment: COPASI2
name: Tni
initial amount: NaN
has only substance units: false
is: SBO:0000253
initial concentration: 0.0
has part: CHEBI:49786
constant: false
boundary condition: false

383071
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

COPASI18
type: Species
has part: P07017
name: Tni_WA
constant: false
in compartment: COPASI2
has part: P07363
has only substance units: false
initial concentration: 0.0
boundary condition: false
has part: CHEBI:49786
has part: P0A964
initial amount: NaN
is: SBO:0000253

383059
type: SpeciesReference
stoichiometry: 1.0
species: COPASI15

557229
type: LocalParameter
value: 1.0
name: k2

557228
type: LocalParameter
value: 0.4
name: k1

COPASI51
type: Reaction
fast: false
reactant: 382241
is: SBO:0000177
kinetic law: 382265
reversible: true
is version of: GO:0070335
name: T+asp<->Tasp
product: 382253
reactant: 382229

382241
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

557195
type: LocalParameter
value: 1.0
name: k2

557194
type: LocalParameter
value: 1000000.0
name: k1

382253
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

382229
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

COPASI5
type: Species
constant: false
in compartment: COPASI2
has only substance units: false
is: P07017
initial amount: NaN
is: SBO:0000245
name: T
initial concentration: 3.12E-6
boundary condition: false

COPASI56
type: Reaction
product: 382495
reactant: 382482
kinetic law: 382507
reversible: true
reactant: 382470
is version of: GO:0006461
fast: false
is: SBO:0000177
name: TW+A<->TWA

382495
type: SpeciesReference
stoichiometry: 1.0
species: COPASI16

382482
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

557205
type: LocalParameter
value: 1.0
name: k2

557204
type: LocalParameter
value: 400000.0
name: k1

382470
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

COPASI60
type: Reaction
product: 382687
reactant: 382675
kinetic law: 382699
is: SBO:0000177
reactant: 382663
is version of: GO:0006461
reversible: true
name: Tasp+A<->Tasp_A
fast: false

382687
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

COPASI13
type: Species
name: Tasp_A
constant: false
boundary condition: false
has part: P07363
is: SBO:0000253
initial amount: NaN
in compartment: COPASI2
has part: P07017
initial concentration: 0.0
has part: CHEBI:35391
has only substance units: false

382675
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

557213
type: LocalParameter
value: 1.0
name: k2

557212
type: LocalParameter
value: 10000.0
name: k1

382663
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

COPASI65
type: Reaction
is version of: GO:0006461
reactant: 382915
is: SBO:0000177
fast: false
name: Tni+A<->Tni_A
reversible: true
product: 382927
kinetic law: 382939
reactant: 382903

382915
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

382927
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

COPASI14
type: Species
is: SBO:0000253
initial concentration: 0.0
initial amount: NaN
has part: CHEBI:49786
has part: P07017
name: Tni_A
boundary condition: false
has part: P07363
has only substance units: false
in compartment: COPASI2
constant: false

557223
type: LocalParameter
value: 1.0
name: k2

557222
type: LocalParameter
value: 0.01
name: k1

382903
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

COPASI11
type: Species
name: Tni_W
has only substance units: false
is: SBO:0000253
initial amount: NaN
boundary condition: false
initial concentration: 0.0
in compartment: COPASI2
has part: CHEBI:49786
constant: false
has part: P0A964
has part: P07017

COPASI44
type: Reaction
reactant: 381880
is: SBO:0000330
product: 381904
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.16
reversible: false
product: 381916
reactant: 381892
kinetic law: 381929
name: Tasp_WA+Yp->Tasp_WA+Y
is version of: GO:0006470

381880
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

381904
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

381916
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

381892
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

557185
type: LocalParameter
value: 1.0E8
name: k1

COPASI53
type: Reaction
is: SBO:0000177
reactant: 382325
fast: false
reactant: 382338
kinetic law: 382362
reversible: true
name: T+W<->TW
product: 382350
is version of: GO:0006461

382325
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

382338
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

557199
type: LocalParameter
value: 1.0
name: k2

557198
type: LocalParameter
value: 100000.0
name: k1

382350
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

COPASI49
type: Reaction
reactant: 382133
name: Ap+B->A+Bp
has part: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000402
product: 382169
kinetic law: 382181
has part: GO:0006470
product: 382157
has part: GO:0006468
reversible: false
has part: http://identifiers.org/ec-code/3.1.3.16
fast: false
reactant: 382145

382133
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

382169
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

COPASI22
type: Species
has only substance units: false
has property: MOD:00696
initial amount: NaN
initial concentration: 6.87E-8
name: Bp
is version of: P07330
constant: false
in compartment: COPASI2
boundary condition: false

557191
type: LocalParameter
value: 1000000.0
name: k1

382157
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

382145
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

COPASI21
type: Species
is: SBO:0000245
has only substance units: false
initial concentration: 1.93E-6
initial amount: NaN
is version of: P07330
name: B
constant: false
in compartment: COPASI2
boundary condition: false

COPASI23
type: Species
constant: false
initial concentration: 2.0E-5
is: SBO:0000245
name: Z
has only substance units: false
initial amount: NaN
is: P0A9H9
boundary condition: false
in compartment: COPASI2

COPASI73
type: Reaction
is: SBO:0000177
fast: false
reactant: 383299
reversible: true
kinetic law: 383323
is version of: GO:0070335
product: 383311
name: TA + asp <-> Tasp_A
reactant: 383287

383299
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

557234
type: LocalParameter
value: 1.0
name: k2

557233
type: LocalParameter
value: 1000000.0
name: k1

383311
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

383287
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

COPASI12
type: Species
in compartment: COPASI2
initial concentration: 4.44E-7
is: SBO:0000253
initial amount: NaN
name: TA
constant: false
has part: P07017
has part: P07363
has only substance units: false
boundary condition: false

COPASI70
type: Reaction
product: 383167
fast: false
name: MYp+Yp<->MYpYp
reactant: 383155
kinetic law: 383179
is version of: GO:0006461
is: SBO:0000177
reactant: 383143
reversible: true

383167
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

383155
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

383143
type: SpeciesReference
stoichiometry: 1.0
species: COPASI27

COPASI75
type: Reaction
product: 383408
name: TWA+asp <-> Tasp_WA
is: SBO:0000177
kinetic law: 383420
reactant: 383396
fast: false
is version of: GO:0070335
reversible: true
reactant: 383384

383408
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

557238
type: LocalParameter
value: 1.0
name: k2

557237
type: LocalParameter
value: 1000000.0
name: k1

383396
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

383384
type: SpeciesReference
stoichiometry: 1.0
species: COPASI16

COPASI38
type: Parameter
constant: true
value: 3.0E-4
name: KmATP

COPASI34
type: Parameter
constant: true
value: 0.1
name: ka

COPASI39
type: Event
event assignment: 383444
trigger: 383432
use values from trigger time: true
name: Add ASP

383432
type: Trigger
persistant: true
initial value: true

COPASI35
type: Parameter
constant: false
value: 0.701419432227109
name: Bias

COPASI30
type: Species
initial concentration: 2.31E-9
name: MYpYpYpYp
boundary condition: false
has part: P06974
has only substance units: false
initial amount: NaN
in compartment: COPASI2
constant: false
is: SBO:0000253
has part: P0AE67

COPASI58
type: Reaction
reactant: 382567
name: T+WA<->TWA
product: 382591
reactant: 382579
is version of: GO:0006461
kinetic law: 382603
is: SBO:0000177
fast: false
reversible: true

382567
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

382591
type: SpeciesReference
stoichiometry: 1.0
species: COPASI16

382579
type: SpeciesReference
stoichiometry: 1.0
species: COPASI15

557209
type: LocalParameter
value: 1.0
name: k2

557208
type: LocalParameter
value: 400000.0
name: k1

COPASI62
type: Reaction
product: 382783
reactant: 382759
kinetic law: 382795
reactant: 382771
reversible: true
is: SBO:0000177
name: Tasp_A+W<->Tasp_WA
is version of: GO:0006461
fast: false

382783
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

382759
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

557217
type: LocalParameter
value: 1.0
name: k2

557216
type: LocalParameter
value: 400000.0
name: k1

382771
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI67
type: Reaction
product: 383023
fast: false
name: Tni_A+W<->Tni_WA
reactant: 383011
is version of: GO:0006461
reactant: 382999
reversible: true
kinetic law: 383035
is: SBO:0000177

383023
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

383011
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

382999
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

557227
type: LocalParameter
value: 1.0
name: k2

557226
type: LocalParameter
value: 0.4
name: k1

COPASI41
type: Reaction
name: A->Ap
reversible: false
is version of: GO:0006468
fast: false
product: 381760
is: SBO:0000216
kinetic law: 381772
reactant: 381748
is version of: http://identifiers.org/ec-code/2.7.11.1

381760
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

557181
type: LocalParameter
value: 0.001
name: kcat

381748
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

COPASI46
type: Reaction
is version of: GO:0006468
kinetic law: 382025
name: Y ->Yp
reversible: false
product: 382013
is: SBO:0000216
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: 382001

557187
type: LocalParameter
value: 0.0
name: kcat

382013
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

382001
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

COPASI50
type: Reaction
kinetic law: 382217
is version of: GO:0006470
name: Bp->B
is version of: http://identifiers.org/ec-code/3.1.3.16
reactant: 382193
fast: false
reversible: false
is: SBO:0000330
product: 382205

557193
type: LocalParameter
value: 1.0
name: k1

382193
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

382205
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

COPASI55
type: Reaction
product: 382446
is version of: GO:0006461
reactant: 382422
fast: false
kinetic law: 382458
name: W+A<->WA
reactant: 382434
reversible: true
is: SBO:0000177

382446
type: SpeciesReference
stoichiometry: 1.0
species: COPASI15

382422
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

557203
type: LocalParameter
value: 1.0
name: k2

557202
type: LocalParameter
value: 100000.0
name: k1

382434
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

COPASI64
type: Reaction
reactant: 382855
name: Tni+W<->Tni_W
product: 382879
is: SBO:0000177
reversible: true
is version of: GO:0006461
kinetic law: 382891
reactant: 382867
fast: false

382855
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

382879
type: SpeciesReference
stoichiometry: 1.0
species: COPASI11

557221
type: LocalParameter
value: 1.0
name: k2

557220
type: LocalParameter
value: 0.1
name: k1

382867
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI26
type: Species
boundary condition: false
has only substance units: false
initial concentration: 6.24E-9
in compartment: COPASI2
constant: false
is: SBO:0000245
initial amount: NaN
name: M
is: P06974

COPASI43
type: Reaction
kinetic law: 381868
is: SBO:0000216
product: 381844
fast: false
reversible: false
name: Tni_WA+A->Tni_WA+Ap
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: 381856
reactant: 381832
is version of: GO:0006468

557183
type: LocalParameter
value: 200000.0
name: kcat

381844
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

381832
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

COPASI48
type: Reaction
reactant: 382073
is: SBO:0000330
product: 382109
product: 382097
is version of: GO:0006470
reversible: false
fast: false
reactant: 382085
name: Yp+Z->Y+Z
is version of: http://identifiers.org/ec-code/3.1.3.16
kinetic law: 382121

382073
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

382109
type: SpeciesReference
stoichiometry: 1.0
species: COPASI23

382097
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

382085
type: SpeciesReference
stoichiometry: 1.0
species: COPASI23

557190
type: LocalParameter
value: 500000.0
name: k1

COPASI72
type: Reaction
kinetic law: 383275
reactant: 383251
reactant: 383239
reversible: true
fast: false
name: MYpYpYp+Yp<->MYpYpYpYp
product: 383263
is version of: GO:0006461
is: SBO:0000177

383251
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

383239
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

383263
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

COPASI40
type: Event
event assignment: 383469
trigger: 383456
use values from trigger time: true
name: Remove ASP

383456
type: Trigger
persistant: true
initial value: true

COPASI4
type: Species
initial concentration: 0.0
in compartment: COPASI2
name: ni
is: SBO:0000247
has only substance units: false
constant: true
boundary condition: true
is: CHEBI:49786
initial amount: NaN

COPASI37
type: Parameter
constant: false
value: 0.997008973080758
name: autoPhospho

COPASI33
type: Parameter
constant: true
value: 2.25E-7
name: kappa

COPASI69
type: Reaction
reversible: true
is: SBO:0000177
reactant: 383095
name: M+Yp<->MYp
product: 383119
kinetic law: 383131
is version of: GO:0006461
fast: false
reactant: 383107

383095
type: SpeciesReference
stoichiometry: 1.0
species: COPASI26

383119
type: SpeciesReference
stoichiometry: 1.0
species: COPASI27

383107
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

COPASI52
type: Reaction
kinetic law: 382313
is: SBO:0000177
reversible: true
reactant: 382277
product: 382301
reactant: 382289
fast: false
name: T+ni<->Tni
is version of: GO:0016151

557197
type: LocalParameter
value: 1.0
name: k2

557196
type: LocalParameter
value: 1000.0
name: k1

382277
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

382301
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

382289
type: SpeciesReference
stoichiometry: 1.0
species: COPASI4

COPASI57
type: Reaction
is: SBO:0000177
name: TA+W<->TWA
reversible: true
reactant: 382531
is version of: GO:0006461
kinetic law: 382555
fast: false
product: 382543
reactant: 382519

382531
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

557207
type: LocalParameter
value: 1.0
name: k2

557206
type: LocalParameter
value: 400000.0
name: k1

382543
type: SpeciesReference
stoichiometry: 1.0
species: COPASI16

382519
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

COPASI61
type: Reaction
is version of: GO:0006461
reactant: 382723
reactant: 382711
fast: false
is: SBO:0000177
kinetic law: 382747
product: 382735
reversible: true
name: Tasp_W+A<->Tasp_WA

382723
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

382711
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

557215
type: LocalParameter
value: 1.0
name: k2

557214
type: LocalParameter
value: 400000.0
name: k1

382735
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

COPASI66
type: Reaction
name: Tni_W+A<->Tni_WA
product: 382975
is: SBO:0000177
reactant: 382951
kinetic law: 382987
reversible: true
fast: false
reactant: 382963
is version of: GO:0006461

382975
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

382951
type: SpeciesReference
stoichiometry: 1.0
species: COPASI11

557225
type: LocalParameter
value: 1.0
name: k2

557224
type: LocalParameter
value: 0.4
name: k1

382963
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

COPASI45
type: Reaction
is version of: GO:0006468
product: 381977
kinetic law: 381989
is: SBO:0000216
reactant: 381953
fast: false
reactant: 381941
product: 381965
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
name: Ap+Y->A+Yp

381977
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

557186
type: LocalParameter
value: 200000.0
name: k1

381953
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

381941
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

381965
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

COPASI54
type: Reaction
name: T+A<->TA
reversible: true
is version of: GO:0006461
fast: false
reactant: 382374
kinetic law: 382410
is: SBO:0000177
product: 382398
reactant: 382386

382374
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

557201
type: LocalParameter
value: 1.0
name: k2

557200
type: LocalParameter
value: 10000.0
name: k1

382398
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

382386
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

W3 CDTF: Thu Mar 08 11:12:55 GMT 2012

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

W3 CDTF: Mon Nov 03 11:29:04 GMT 2008

ORG:
  orgname: Department of Physiology, Development and Neuroscience - University of Cambridge
n:
  given: Dennis
  family: Bray