Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05616 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1)
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05627 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05615 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/Casein Kinase 1/_br_Glycogen Synthase Kinase-3_Beta_/PP2A)
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05607 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)
mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05609 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A)
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05633 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A)
Long Name: Low density lipoprotein receptor related protein Synonym: Arrow Accession: P01431
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05637 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05629 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd#
Long Name: Casein Kinase 1 Synonym: CK1 Accession: P01460
reversible rapid-equilibrium random order ternary-complex mechanism with two products
Long Name: ADP Synonym: Synonym not specified Accession: S01880
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05626 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;LRP5/6#PROTEIN#Low density lipoprotein receptor related protein#P01431#Arrow#;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless#
Long Name: ATP Synonym: Synonym not specified Accession: S01878
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05624 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05608 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05622 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05623 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;SWI/SNF#PROTEIN#Switched/Sucrose Non Fermentation#P01435#Switched/Sucrose Non Fermentation#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05611 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A)
Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444
Long Name: Switched/Sucrose Non Fermentation Synonym: Switched/Sucrose Non Fermentation Accession: P01435
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05613 Heterodimer Member Info: TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05636 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
Long Name: B-cell lymphoma 9 Synonym: B-cell lymphoma 9,Legless,Lgs Accession: P01450
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05606 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05641 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;Frodo#PROTEIN#Frodo#P01470#frd#
Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2)
Long Name: CREB binding protein Synonym: CREB binding protein Accession: P01448
Long Name: Casein Kinase 2 Synonym: Casein Kinase II,Protein Kinase CK2 Accession: P01459
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05625 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A)
Long Name: Wnt Target Genes Synonym: Axin,Conductin,CyclinD1,En-2,ID2,MMP7,Myc,Naked,Nkd,PPAR Delta,Siamois,TCF-1,Twin,Ubx,Xbra,Xnr3 Accession: G01558
Long Name: Diversin Synonym: Ankrd6 Accession: P01466
mass action rate law for first order irreversible reactions, continuous scheme
This model is from the article: A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways. Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S. OMICS 2011 Oct;15(10):729-37. 21978399 , Abstract: The Notch, Sonic Hedgehog (Shh), Wnt, and EGF pathways have long been known to in fluence cell fate specification in the developing nervous system. Here we attempt ed to evaluate the contemporary knowledge about neural stem cell differentiation promoted by various drug-based regulations through a systems biology approach. Ou r model showed the phenomenon of DAPT-mediated antagonism of Enhancer of split [E (spl)] genes and enhancement of Shh target genes by a SAG agonist that were effec tively demonstrated computationally and were consistent with experimental studies . However, in the case of model simulation of Wnt and EGF pathways, the model net work did not supply any concurrent results with experimental data despite the fac t that drugs were added at the appropriate positions. This paves insight into the potential of crosstalks between pathways considered in our study. Therefore, we manually developed a map of signaling crosstalk, which included the species conne cted by representatives from Notch, Shh, Wnt, and EGF pathways and highlighted th e regulation of a single target gene, Hes-1, based on drug-induced simulations. T hese simulations provided results that matched with experimental studies. Therefo re, these signaling crosstalk models complement as a tool toward the discovery of novel regulatory processes involved in neural stem cell maintenance, proliferati on, and differentiation during mammalian central nervous system development. To o ur knowledge, this is the first report of a simple crosstalk map that highlights the differential regulation of neural stem cell differentiation and underscores t he flow of positive and negative regulatory signals modulated by drugs. Note: The secreted protein Wnt activates the heptahelical receptor Frizzled on nieghboring cells. Activation of Frizzled causes the recruitment of additional membrane proteins which in turn result in 1) the activation of the protein Dishevelled via phosphorylation and 2) the activation of a heterotrimeric G protein of unknown type. Activation of Dishevelled results in the down-regulation of the Beta-Catenin destruction complex which causes ubiquitination of Beta-Catenin and its ultimate degradation via the proteasome. Inhibition of the Beta-Catenin destruction complex yields a higher cytosolic concentration of Beta-Catenin, which enters the nucleus, binds various transcriptional regulatory molecules including the TCF/LEF class of proteins, and results in the transcription of TCF/LEF target genes. Activation of the heterotrimeric G-protein pathway in turn activates Phospholipase C which in turn catalyzes the catalysis of PI(4,5)P2 into DAG and IP3. References: 12356903 , 12573432 & Wnt signaling pathway
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05619 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus#
Long Name: Pygopus Synonym: Pygopus Accession: P01464
Long Name: Frequently rearranged in advanced T-cell lymphomas Synonym: Frequently rearranged in advanced T-cell lymphomas Accession: P01467
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05614 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Axin/PP2A/_br_Adenomatous Polyposis Coli)
Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01883
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05620 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;FRAT#PROTEIN#Frequently rearranged in advanced T-cell lymphomas#P01467#Frequently rearranged in advanced T-cell lymphomas#;Frodo#PROTEIN#Frodo#P01470#frd#
Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT)
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05617 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi)
Long Name: Glycogen Synthase Kinase-3Beta Synonym: GSK3B,GSK3Beta,Sgg,Shaggy,Zeste White 3,Zw3 Accession: P01441
reversible thermodynamically independent convenience kinetics
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05639 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1)
Long Name: betaTransducin repeat-containing protein Synonym: BTrCP,Beta Transducin Repeat-Containing Protein,Slimb Accession: P01454
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05635 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A)
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05612 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1#
Long Name: Frizzled Synonym: Synonym not specified Accession: P01428