BIOMD0000000397
type: SBMLModel
parameter: 181040
species: 180521
reaction: 180812
species: 180572
species: 180441
parameter: 181148
species: 180154
reaction: 180929
curated: true
parameter: 181098
species: 180104
species: 180632
reaction: 180755
species: 180137
species: 180270
parameter: 181144
species: 180511
parameter: 181046
compartment: 180039
species: 180351
parameter: 181140
species: 180087
species: 180381
species: 180411
reaction: 180967
parameter: 181092
species: 180653
species: 180602
species: 180371
parameter: 181146
species: 180321
species: 180187
reaction: 180943
species: 180170
species: 180401
species: 180254
reaction: 180907
parameter: 181142
parameter: 181076
reaction: 180990
name: Sivakumar2011_WntSignalingPathway
species: 180562
parameter: 181056
reaction: 180979
species: 180643
parameter: 181072
reaction: 180707
parameter: 181052
reaction: 180730
parameter: 181094
parameter: 181041
species: 180674
notes: This model is from the article: A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways. Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S. OMICS 2011 Oct;15(10):729-37. 21978399 , Abstract: The Notch, Sonic Hedgehog (Shh), Wnt, and EGF pathways have long been known to in fluence cell fate specification in the developing nervous system. Here we attempt ed to evaluate the contemporary knowledge about neural stem cell differentiation promoted by various drug-based regulations through a systems biology approach. Ou r model showed the phenomenon of DAPT-mediated antagonism of Enhancer of split [E (spl)] genes and enhancement of Shh target genes by a SAG agonist that were effec tively demonstrated computationally and were consistent with experimental studies . However, in the case of model simulation of Wnt and EGF pathways, the model net work did not supply any concurrent results with experimental data despite the fac t that drugs were added at the appropriate positions. This paves insight into the potential of crosstalks between pathways considered in our study. Therefore, we manually developed a map of signaling crosstalk, which included the species conne cted by representatives from Notch, Shh, Wnt, and EGF pathways and highlighted th e regulation of a single target gene, Hes-1, based on drug-induced simulations. T hese simulations provided results that matched with experimental studies. Therefo re, these signaling crosstalk models complement as a tool toward the discovery of novel regulatory processes involved in neural stem cell maintenance, proliferati on, and differentiation during mammalian central nervous system development. To o ur knowledge, this is the first report of a simple crosstalk map that highlights the differential regulation of neural stem cell differentiation and underscores t he flow of positive and negative regulatory signals modulated by drugs. Note: The secreted protein Wnt activate…
reaction: 180955
species: 180341
species: 180304
parameter: 181080
parameter: 181090
parameter: 181088
reaction: 180766
is version of: GO:0060070
occurs in: http://identifiers.org/taxonomy/40674
parameter: 181128
parameter: 181070
parameter: 181068
parameter: 181078
is: MODEL1101270002
species: 180220
parameter: 181150
parameter: 181084
parameter: 181108
volume units: 142784
species: 180471
parameter: 181058
parameter: 181124
reaction: 180719
parameter: 181064
parameter: 181074
reaction: 181001

181040
type: Parameter
constant: true
value: 0.784

180521
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05616 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1)

180039
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: Plasma Membrane

180812
type: Reaction
kinetic law: 226118
product: 226105
product: 226092
reactant: 226079
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true

226105
type: SpeciesReference
stoichiometry: 1.0
species: 180653

180653
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05627 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(_beta_TrCP/_Beta_-Catenin)

226092
type: SpeciesReference
stoichiometry: 1.0
species: 180341

180341
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05615 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/Casein Kinase 1/_br_Glycogen Synthase Kinase-3_Beta_/PP2A)

226079
type: SpeciesReference
stoichiometry: 1.0
species: 180643

180643
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05607 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)

180572
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05609 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A)

180441
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05633 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A)

181148
type: Parameter
constant: true
value: 0.7

180154
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is version of: O75581
name: LRP5/6
in compartment: 180039
boundary condition: false
notes: Long Name: Low density lipoprotein receptor related protein Synonym: Arrow Accession: P01431
initial amount: 3.0
is version of: O75197

180929
type: Reaction
reactant: 226539
reversible: true
product: 226563
modifier: 226599
notes: reversible rapid-equilibrium random order ternary-complex mechanism with two products
fast: false
product: 226575
kinetic law: 226611
modifier: 226587
reactant: 226551

226539
type: SpeciesReference
stoichiometry: 1.0
species: 180321

180321
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05637 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 3.0
in compartment: 180039
name: Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)

226563
type: SpeciesReference
stoichiometry: 1.0
species: 180592

180592
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05629 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)

180170
type: Species
in compartment: 180039
notes: Long Name: Casein Kinase 1 Synonym: CK1 Accession: P01460
has only substance units: false
boundary condition: false
name: Casein Kinase 1
initial concentration: NaN
constant: false
is version of: P54367
initial amount: 1.0

226575
type: SpeciesReference
stoichiometry: 1.0
species: 180220

180220
type: Species
constant: false
is version of: CHEBI:16761
initial concentration: NaN
boundary condition: false
notes: Long Name: ADP Synonym: Synonym not specified Accession: S01880
in compartment: 180039
initial amount: 0.0
name: ADP
has only substance units: false

180137
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05626 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;LRP5/6#PROTEIN#Low density lipoprotein receptor related protein#P01431#Arrow#;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Frizzled/Wnt/_br_LRP5/6)

226551
type: SpeciesReference
stoichiometry: 1.0
species: 180204

180204
type: Species
in compartment: 180039
notes: Long Name: ATP Synonym: Synonym not specified Accession: S01878
name: ATP
boundary condition: false
initial concentration: NaN
initial amount: 1.0
has only substance units: false
is version of: CHEBI:15422
constant: false

181098
type: Parameter
constant: true
value: 1.45

180104
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05624 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Wnt/Frizzled)

180632
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05608 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)

180755
type: Reaction
kinetic law: 225865
product: 225852
reactant: 225839
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true

225852
type: SpeciesReference
stoichiometry: 1.0
species: 180471

180471
type: Species
initial amount: 0.0
initial concentration: NaN
name: _Beta_-Catenin
is version of: P35222
in compartment: 180055
constant: false
has only substance units: false
boundary condition: false
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432

180055
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: Nucleus

225839
type: SpeciesReference
stoichiometry: 1.0
species: 180431

180431
type: Species
in compartment: 180039
name: _Beta_-Catenin
boundary condition: false
constant: false
initial concentration: NaN
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
has only substance units: false
initial amount: 5.0
is version of: P35222

180270
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05622 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 3.0
in compartment: 180039
name: Complex_br_(Ebi/Siah-1)

181144
type: Parameter
constant: true
value: 1.32

180511
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05623 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;SWI/SNF#PROTEIN#Switched/Sucrose Non Fermentation#P01435#Switched/Sucrose Non Fermentation#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(_Beta_-Catenin/TCF/_br_Smad4/Bcl9/_br_Pygo/SWI/_br_SNF)

181046
type: Parameter
constant: true
value: 0.92

180351
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05611 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A)

181140
type: Parameter
constant: true
value: 0.83

180087
type: Species
constant: false
is version of: P56704
name: Wnt
initial concentration: NaN
has only substance units: false
notes: Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444
initial amount: 0.0
boundary condition: false
in compartment: 180038

180038
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0

180381
type: Species
name: SWI/SNF
initial concentration: NaN
initial amount: 2.0
is version of: O60264
notes: Long Name: Switched/Sucrose Non Fermentation Synonym: Switched/Sucrose Non Fermentation Accession: P01435
constant: false
has only substance units: false
in compartment: 180055
boundary condition: false

180411
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05613 Heterodimer Member Info: TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 4.0
in compartment: 180055
name: Complex_br_(TCF/Smad4)

180967
type: Reaction
kinetic law: 226782
product: 226770
reactant: 226758
reactant: 226746
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226770
type: SpeciesReference
stoichiometry: 1.0
species: 180491

180491
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05636 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(TCF/_Beta_-Catenin/_br_Smad4/Bcl9)

226758
type: SpeciesReference
stoichiometry: 1.0
species: 180391

180391
type: Species
initial concentration: NaN
name: Bcl9
is version of: O00512
in compartment: 180055
initial amount: 2.0
has only substance units: false
notes: Long Name: B-cell lymphoma 9 Synonym: B-cell lymphoma 9,Legless,Lgs Accession: P01450
boundary condition: false
constant: false

226746
type: SpeciesReference
stoichiometry: 1.0
species: 180481

180481
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05606 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(TCF/Smad4/_br__Beta_-Catenin)

181092
type: Parameter
constant: true
value: 1.16

180602
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05641 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2)

180371
type: Species
boundary condition: false
name: CBP
has only substance units: false
initial amount: 2.0
initial concentration: NaN
notes: Long Name: CREB binding protein Synonym: CREB binding protein Accession: P01448
is version of: P45481
constant: false
in compartment: 180055

181146
type: Parameter
constant: true
value: 0.86

180187
type: Species
constant: false
has part: P67870
name: Casein Kinase 2
boundary condition: false
has only substance units: false
notes: Long Name: Casein Kinase 2 Synonym: Casein Kinase II,Protein Kinase CK2 Accession: P01459
in compartment: 180039
initial amount: 3.0
initial concentration: NaN
has part: P68400

180943
type: Reaction
reversible: true
product: 226660
fast: false
reactant: 226624
reactant: 226636
modifier: 226672
notes: reversible rapid-equilibrium random order ternary-complex mechanism with two products
kinetic law: 226684
product: 226648

226660
type: SpeciesReference
stoichiometry: 1.0
species: 180220

226624
type: SpeciesReference
stoichiometry: 1.0
species: 180451

180451
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05625 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A)

226636
type: SpeciesReference
stoichiometry: 1.0
species: 180204

226648
type: SpeciesReference
stoichiometry: 1.0
species: 180521

180401
type: Species
notes: Long Name: Wnt Target Genes Synonym: Axin,Conductin,CyclinD1,En-2,ID2,MMP7,Myc,Naked,Nkd,PPAR Delta,Siamois,TCF-1,Twin,Ubx,Xbra,Xnr3 Accession: G01558
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Wnt Target Genes

180254
type: Species
in compartment: 180039
notes: Long Name: Diversin Synonym: Ankrd6 Accession: P01466
initial concentration: NaN
initial amount: 1.0
boundary condition: false
name: Diversin
is homolog to: Q8UVT6
has only substance units: false
constant: false

180907
type: Reaction
kinetic law: 226489
product: 226477
reactant: 226465
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true

226477
type: SpeciesReference
stoichiometry: 1.0
species: 180170

226465
type: SpeciesReference
stoichiometry: 1.0
species: 180592

181142
type: Parameter
constant: true
value: 0.87

181076
type: Parameter
constant: true
value: 1.99

180990
type: Reaction
kinetic law: 226856
product: 226844
reactant: 226832
notes: mass action rate law for first order irreversible reactions, continuous scheme
fast: false
reversible: false

226844
type: SpeciesReference
stoichiometry: 1.0
species: 180471

226832
type: SpeciesReference
stoichiometry: 1.0
species: 180562

180562
type: Species
constant: false
name: _Beta_-Catenin
initial concentration: NaN
in compartment: 180039
has only substance units: false
boundary condition: false
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
is version of: P35222
initial amount: 0.0

181056
type: Parameter
constant: true
value: 0.8

180979
type: Reaction
kinetic law: 226819
product: 226807
reactant: 226795
notes: mass action rate law for first order irreversible reactions, continuous scheme
fast: false
reversible: false

226807
type: SpeciesReference
stoichiometry: 1.0
species: 180471

226795
type: SpeciesReference
stoichiometry: 1.0
species: 180551

180551
type: Species
initial amount: 0.0
boundary condition: false
constant: false
in compartment: 180039
initial concentration: NaN
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
is version of: P35222
name: _Beta_-Catenin
has only substance units: false

181072
type: Parameter
constant: true
value: 1.8

180707
type: Reaction
kinetic law: 225673
product: 225660
reactant: 225647
reactant: 225635
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

225660
type: SpeciesReference
stoichiometry: 1.0
species: 180137

225647
type: SpeciesReference
stoichiometry: 1.0
species: 180104

225635
type: SpeciesReference
stoichiometry: 1.0
species: 180154

181052
type: Parameter
constant: true
value: 0.85

180730
type: Reaction
kinetic law: 225775
product: 225762
reactant: 225749
reactant: 225737
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

225762
type: SpeciesReference
stoichiometry: 1.0
species: 180451

225749
type: SpeciesReference
stoichiometry: 1.0
species: 180254

225737
type: SpeciesReference
stoichiometry: 1.0
species: 180441

181094
type: Parameter
constant: true
value: 0.58

181041
type: Parameter
constant: true
value: 0.82

180674
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(Bcl9/Pygo/../Smad4)

180955
type: Reaction
kinetic law: 226733
product: 226721
reactant: 226709
reactant: 226697
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226721
type: SpeciesReference
stoichiometry: 1.0
species: 180501

180501
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05619 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(Bcl9/_Beta_-Catenin/_br_TCF/Smad4/_br_Pygo)

226709
type: SpeciesReference
stoichiometry: 1.0
species: 180361

180361
type: Species
initial amount: 2.0
is version of: Q9V9W8
notes: Long Name: Pygopus Synonym: Pygopus Accession: P01464
in compartment: 180055
name: Pygo
boundary condition: false
initial concentration: NaN
has only substance units: false
constant: false

226697
type: SpeciesReference
stoichiometry: 1.0
species: 180491

180304
type: Species
initial concentration: NaN
has only substance units: false
name: FRAT
notes: Long Name: Frequently rearranged in advanced T-cell lymphomas Synonym: Frequently rearranged in advanced T-cell lymphomas Accession: P01467
boundary condition: false
in compartment: 180039
constant: false
is version of: Q92837
initial amount: 3.0

181080
type: Parameter
constant: true
value: 2.0

181090
type: Parameter
constant: true
value: 0.36

181088
type: Parameter
constant: true
value: 1.028

180766
type: Reaction
kinetic law: 225916
product: 225903
reactant: 225890
reactant: 225878
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

225903
type: SpeciesReference
stoichiometry: 1.0
species: 180481

225890
type: SpeciesReference
stoichiometry: 1.0
species: 180471

225878
type: SpeciesReference
stoichiometry: 1.0
species: 180411

181128
type: Parameter
constant: true
value: 1.056

181070
type: Parameter
constant: true
value: 0.72

181068
type: Parameter
constant: true
value: 1.29

181078
type: Parameter
constant: true
value: 0.036

181150
type: Parameter
constant: true
value: 1.43

181084
type: Parameter
constant: true
value: 1.09

181108
type: Parameter
constant: true
value: 0.854

181058
type: Parameter
constant: true
value: 1.7

181124
type: Parameter
constant: true
value: 1.13

180719
type: Reaction
kinetic law: 225724
product: 225711
reactant: 225698
reactant: 225686
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

225711
type: SpeciesReference
stoichiometry: 1.0
species: 180441

225698
type: SpeciesReference
stoichiometry: 1.0
species: 180431

225686
type: SpeciesReference
stoichiometry: 1.0
species: 180331

180331
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05614 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 4.0
in compartment: 180039
name: Complex_br_(Axin/PP2A/_br_Adenomatous Polyposis Coli)

181064
type: Parameter
constant: true
value: 1.77

181074
type: Parameter
constant: true
value: 0.004

181001
type: Reaction
kinetic law: 226905
product: 226893
reactant: 226881
reactant: 226869
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226893
type: SpeciesReference
stoichiometry: 1.0
species: 180674

226881
type: SpeciesReference
stoichiometry: 1.0
species: 180371

226869
type: SpeciesReference
stoichiometry: 1.0
species: 180511

180684
type: Reaction
kinetic law: 225571
product: 225558
reactant: 225545
fast: false
reversible: false

225558
type: SpeciesReference
stoichiometry: 1.0
species: 180401

225545
type: SpeciesReference
stoichiometry: 1.0
species: 180674

181104
type: Parameter
constant: true
value: 1.09

181054
type: Parameter
constant: true
value: 1.36

181120
type: Parameter
constant: true
value: 1.62

181060
type: Parameter
constant: true
value: 1.74

180541
type: Species
notes: Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1.0
in compartment: 180039
name: Ubiquitin

181100
type: Parameter
constant: true
value: 0.183

181050
type: Parameter
constant: true
value: 0.81

181082
type: Parameter
constant: true
value: 0.2

180884
type: Reaction
kinetic law: 226415
product: 226403
reactant: 226390
reactant: 226378
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226403
type: SpeciesReference
stoichiometry: 1.0
species: 180612

180612
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05620 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;FRAT#PROTEIN#Frequently rearranged in advanced T-cell lymphomas#P01467#Frequently rearranged in advanced T-cell lymphomas#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT)

226390
type: SpeciesReference
stoichiometry: 1.0
species: 180304

226378
type: SpeciesReference
stoichiometry: 1.0
species: 180602

180461
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05617 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi)

180801
type: Reaction
kinetic law: 226066
product: 226054
reactant: 226042
reactant: 226030
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226054
type: SpeciesReference
stoichiometry: 1.0
species: 180643

226042
type: SpeciesReference
stoichiometry: 1.0
species: 180541

226030
type: SpeciesReference
stoichiometry: 1.0
species: 180632

181136
type: Parameter
constant: true
value: 0.649

181086
type: Parameter
constant: true
value: 0.27

181013
type: Reaction
modifier: 227014
reactant: 226943
reactant: 226918
modifier: 227026
reactant: 226931
product: 226990
reactant: 226955
fast: false
kinetic law: 227038
product: 227002
notes: reversible thermodynamically independent convenience kinetics
reversible: true
product: 226967
product: 226979

180237
type: Species
boundary condition: false
initial concentration: NaN
initial amount: 0.0
notes: Long Name: Glycogen Synthase Kinase-3Beta Synonym: GSK3B,GSK3Beta,Sgg,Shaggy,Zeste White 3,Zw3 Accession: P01441
in compartment: 180039
is version of: P49841
constant: false
has only substance units: false
name: Glycogen Synthase Kinase-3_Beta_

226943
type: SpeciesReference
stoichiometry: 1.0
species: 180204

226918
type: SpeciesReference
stoichiometry: 1.0
species: 180521

180663
type: Species
is version of: CHEBI:25750
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.5
in compartment: 180039
name: 6 bromoindirubin 3'oxime

226931
type: SpeciesReference
stoichiometry: 1.0
species: 180204

226990
type: SpeciesReference
stoichiometry: 1.0
species: 180220

226955
type: SpeciesReference
stoichiometry: 1.0
species: 180204

227002
type: SpeciesReference
stoichiometry: 1.0
species: 180220

226967
type: SpeciesReference
stoichiometry: 1.0
species: 180531

180531
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05639 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 5.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1)

226979
type: SpeciesReference
stoichiometry: 1.0
species: 180220

180918
type: Reaction
kinetic law: 226526
product: 226514
reactant: 226502
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true

226514
type: SpeciesReference
stoichiometry: 1.0
species: 180087

226502
type: SpeciesReference
stoichiometry: 1.0
species: 180421

180421
type: Species
has only substance units: false
boundary condition: false
in compartment: 180071
is homolog to: A4F2Q1
notes: Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444
constant: false
initial concentration: NaN
name: Wnt
initial amount: 5.0

180071
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cell Membrane

180789
type: Reaction
kinetic law: 226017
product: 226004
reactant: 225992
reactant: 225980
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226004
type: SpeciesReference
stoichiometry: 1.0
species: 180632

225992
type: SpeciesReference
stoichiometry: 1.0
species: 180622

180622
type: Species
constant: false
boundary condition: false
is homolog to: Q91854
name: _beta_TrCP
in compartment: 180039
initial concentration: NaN
notes: Long Name: betaTransducin repeat-containing protein Synonym: BTrCP,Beta Transducin Repeat-Containing Protein,Slimb Accession: P01454
initial amount: 2.0
has only substance units: false

225980
type: SpeciesReference
stoichiometry: 1.0
species: 180531

181116
type: Parameter
constant: true
value: 1.277

181126
type: Parameter
constant: true
value: 0.91

180860
type: Reaction
kinetic law: 226316
product: 226304
product: 226292
reactant: 226280
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true

226304
type: SpeciesReference
stoichiometry: 1.0
species: 180562

226292
type: SpeciesReference
stoichiometry: 1.0
species: 180351

226280
type: SpeciesReference
stoichiometry: 1.0
species: 180582

180582
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05635 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A)

181066
type: Parameter
constant: true
value: 0.61

181132
type: Parameter
constant: true
value: 1.278

181106
type: Parameter
constant: true
value: 0.51

W3 CDTF: Fri Apr 20 20:39:01 BST 2012

181112
type: Parameter
constant: true
value: 1.65

180848
type: Reaction
kinetic law: 226267
product: 226255
product: 226243
reactant: 226231
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true

226255
type: SpeciesReference
stoichiometry: 1.0
species: 180582

226243
type: SpeciesReference
stoichiometry: 1.0
species: 180287

180287
type: Species
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05612 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Siah-1/Ebi)

226231
type: SpeciesReference
stoichiometry: 1.0
species: 180572

181122
type: Parameter
constant: true
value: 0.05

181062
type: Parameter
constant: true
value: 0.25

180896
type: Reaction
kinetic law: 226452
product: 226440
reactant: 226428
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true

226440
type: SpeciesReference
stoichiometry: 1.0
species: 180237

226428
type: SpeciesReference
stoichiometry: 1.0
species: 180612

181102
type: Parameter
constant: true
value: 1.97

180824
type: Reaction
kinetic law: 226168
product: 226156
product: 226144
reactant: 226131
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true

226156
type: SpeciesReference
stoichiometry: 1.0
species: 180551

226144
type: SpeciesReference
stoichiometry: 1.0
species: 180622

226131
type: SpeciesReference
stoichiometry: 1.0
species: 180653

181138
type: Parameter
constant: true
value: 1.68

180872
type: Reaction
kinetic law: 226365
product: 226353
reactant: 226341
reactant: 226329
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226353
type: SpeciesReference
stoichiometry: 1.0
species: 180602

226341
type: SpeciesReference
stoichiometry: 1.0
species: 180187

226329
type: SpeciesReference
stoichiometry: 1.0
species: 180592

181118
type: Parameter
constant: true
value: 0.48

181134
type: Parameter
constant: true
value: 0.7

180120
type: Species
initial amount: 3.0
initial concentration: NaN
has only substance units: false
notes: Long Name: Frizzled Synonym: Synonym not specified Accession: P01428
boundary condition: false
name: Frizzled
constant: false
in compartment: 180039
is version of: P18537

181096
type: Parameter
constant: true
value: 0.92

180777
type: Reaction
kinetic law: 225967
product: 225954
reactant: 225941
reactant: 225929
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

225954
type: SpeciesReference
stoichiometry: 1.0
species: 180511

225941
type: SpeciesReference
stoichiometry: 1.0
species: 180381

225929
type: SpeciesReference
stoichiometry: 1.0
species: 180501

181114
type: Parameter
constant: true
value: 0.45

181048
type: Parameter
constant: true
value: 1.31

181130
type: Parameter
constant: true
value: 0.39

180695
type: Reaction
kinetic law: 225622
product: 225609
reactant: 225596
reactant: 225584
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

225609
type: SpeciesReference
stoichiometry: 1.0
species: 180104

225596
type: SpeciesReference
stoichiometry: 1.0
species: 180120

225584
type: SpeciesReference
stoichiometry: 1.0
species: 180087

180743
type: Reaction
kinetic law: 225826
product: 225813
reactant: 225800
reactant: 225788
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

225813
type: SpeciesReference
stoichiometry: 1.0
species: 180461

225800
type: SpeciesReference
stoichiometry: 1.0
species: 180270

225788
type: SpeciesReference
stoichiometry: 1.0
species: 180441

180836
type: Reaction
kinetic law: 226218
product: 226206
reactant: 226193
reactant: 226181
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true

226206
type: SpeciesReference
stoichiometry: 1.0
species: 180572

226193
type: SpeciesReference
stoichiometry: 1.0
species: 180541

226181
type: SpeciesReference
stoichiometry: 1.0
species: 180461

181110
type: Parameter
constant: true
value: 0.163

181044
type: Parameter
constant: true
value: 1.15

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

ORG:
  orgname: Rajiv Gandhi Centre for Biotechnology
n:
  given: KC
  family: Sivakumar

W3 CDTF: Wed Nov 02 14:46:25 GMT 2011