Long Name: a46_degraded Synonym: Synonym not specified Accession: U02510
Long Name: Long Name: Suppressor of Hairless and Co-repressors Synonym: Synonym not specified Accession: U05412 Heterodimer Member Info: Su(H)#PROTEIN#Suppressor of Hairless [Su(H)]#P01101#C-promoter binding factor 1|CBF1|IKJRB1|Immunoglobulin Kappa J region recombination signal-binding protein 1|LAG-1#;CoR#PROTEIN#Co-repressors#P01112##
Long Name: Co-repressors Synonym: Synonym not specified Accession: P01112
Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120
Long Name: Suppressor of Hairless [Su(H)] Synonym: C-promoter binding factor 1,CBF1,IKJRB1,Immunoglobulin Kappa J region recombination signal-binding protein 1,LAG-1 Accession: P01101
Long Name: Notch intracellular tethered fragment Synonym: Synonym not specified Accession: P01119
Long Name: Notch transmembrane domain fragment Synonym: Synonym not specified Accession: P01114
Long Name: Serrate Synonym: APX-1,F16B12.2,Jagged1,Jagged2 Accession: P01104
Long Name: Enhancer of Split complex genes Synonym: Synonym not specified Accession: G01541
Long Name: Delta Synonym: Delta-like1,Delta-like3,Delta-like4,DeltaC,LAG-2 Accession: P01116
Long Name: LNXp80 Synonym: Ligand of Numb-protein X 80 kDa Accession: P01111
Long Name: a25_degraded Synonym: Synonym not specified Accession: U02509
Long Name: Numb Synonym: Synonym not specified Accession: P01118
kinetics of non-modulated unireactant enzymes
Long Name: Neurotic Synonym: O-fucosyltransferase 1,O-fut1,OFUT1,Ofut1 Accession: P01115
reversible rapid-equilibrium random order ternary-complex mechanism with one product
Long Name: Fucose Synonym: Synonym not specified Accession: S01795
Long Name: Notch Synonym: GLP-1,LIN-12,Notch1,Notch2,Notch3,Notch4 Accession: P01099
Long Name: Sel 10 Synonym: Synonym not specified Accession: P01102
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05413 Heterodimer Member Info: CoA#PROTEIN#Co-Activators#P01100##;Su(H)#PROTEIN#Suppressor of Hairless [Su(H)]#P01101#C-promoter binding factor 1|CBF1|IKJRB1|Immunoglobulin Kappa J region recombination signal-binding protein 1|LAG-1#;Mastermind#PROTEIN#Mastermind#P01106#MECT-1|Mastermind-like 1 (MAML1)|Mastermind-like2 (MAML2)|Mastermind-like3(MAML3)|mucoepidermoid carcinoma-translocated 1#;NIcs#PROTEIN#Notch intracellular soluble fragment#P01120##
Long Name: Co-Activators Synonym: Synonym not specified Accession: P01100
Long Name: Mastermind Synonym: MECT-1,Mastermind-like 1 (MAML1),Mastermind-like2 (MAML2),Mastermind-like3(MAML3),mucoepidermoid carcinoma-translocated 1 Accession: P01106
mass action rate law for , reversible reactions, continuous scheme
Long Name: a7_degraded Synonym: Synonym not specified Accession: U02511
Long Name: Long Name: Serrate and Notch extracellular fragment Synonym: Synonym not specified Accession: U05414 Heterodimer Member Info: Next#PROTEIN#Serrate and Notch extracellular fragment#P01103##;Serrate#PROTEIN#Serrate#P01104#APX-1|F16B12.2|Jagged1|Jagged2#
Long Name: Long Name: Serrate and Notch (fucosylated) Synonym: Synonym not specified Accession: U05410 Heterodimer Member Info: Notch#PROTEIN#Notch#P01099#GLP-1|LIN-12|Notch1|Notch2|Notch3|Notch4#;Serrate#PROTEIN#Serrate#P01104#APX-1|F16B12.2|Jagged1|Jagged2#
Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01796
mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
Long Name: Fringe Synonym: Lunatic Fringe,Manic Fringe,Radical Fringe Accession: P01107
Long Name: Neuralized Synonym: Neu Accession: P01117
Long Name: Long Name: Delta and Notch (fucosylated) Synonym: Synonym not specified Accession: U05411 Heterodimer Member Info: Notch#PROTEIN#Notch#P01099#GLP-1|LIN-12|Notch1|Notch2|Notch3|Notch4#;Delta#PROTEIN#Delta#P01116#Delta-like1|Delta-like3|Delta-like4|DeltaC|LAG-2#
Long Name: TACE Synonym: A disintegrin and metalloproteinase domain 17,ADAM17,Tumor necrosis factor alpha converting enzyme Accession: P01105
mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
Long Name: Long Name: Delta and Notch extracellular fragment Synonym: Synonym not specified Accession: U05409 Heterodimer Member Info: Next#PROTEIN#Serrate and Notch extracellular fragment#P01103##;Delta#PROTEIN#Delta#P01116#Delta-like1|Delta-like3|Delta-like4|DeltaC|LAG-2#
This model is from the article: A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways. Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S. OMICS 2011 Oct;15(10):729-37. 21978399 , Abstract: The Notch, Sonic Hedgehog (Shh), Wnt, and EGF pathways have long been known to in fluence cell fate specification in the developing nervous system. Here we attempt ed to evaluate the contemporary knowledge about neural stem cell differentiation promoted by various drug-based regulations through a systems biology approach. Ou r model showed the phenomenon of DAPT-mediated antagonism of Enhancer of split [E (spl)] genes and enhancement of Shh target genes by a SAG agonist that were effec tively demonstrated computationally and were consistent with experimental studies . However, in the case of model simulation of Wnt and EGF pathways, the model net work did not supply any concurrent results with experimental data despite the fac t that drugs were added at the appropriate positions. This paves insight into the potential of crosstalks between pathways considered in our study. Therefore, we manually developed a map of signaling crosstalk, which included the species conne cted by representatives from Notch, Shh, Wnt, and EGF pathways and highlighted th e regulation of a single target gene, Hes-1, based on drug-induced simulations. T hese simulations provided results that matched with experimental studies. Therefo re, these signaling crosstalk models complement as a tool toward the discovery of novel regulatory processes involved in neural stem cell maintenance, proliferati on, and differentiation during mammalian central nervous system development. To o ur knowledge, this is the first report of a simple crosstalk map that highlights the differential regulation of neural stem cell differentiation and underscores t he flow of positive and negative regulatory signals modulated by drugs. Note: Notch is a transmembrane receptor that mediates local cell-cell co mmunication and coordinates a signaling cascade. It plays a key role in modulati ng cell fate decisions throughout the development of invertebrate and vertebrate species and the misregulation leads to a number of human diseases. Eg: 11112321 , 12366684 , 12651094 , 12676578 & 14973298 .