Long Name: EGFR Synonym: Gurken receptor, Erb, Neu, neuregulin Accession: P00542
mass action rate law for second order irreversible reactions, two reactants, continuous scheme
This model is from the article: A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways. Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S. OMICS 2011 Oct;15(10):729-37. 21978399 , Abstract: The Notch, Sonic Hedgehog (Shh), Wnt, and EGF pathways have long been known to in fluence cell fate specification in the developing nervous system. Here we attempt ed to evaluate the contemporary knowledge about neural stem cell differentiation promoted by various drug-based regulations through a systems biology approach. Ou r model showed the phenomenon of DAPT-mediated antagonism of Enhancer of split [E (spl)] genes and enhancement of Shh target genes by a SAG agonist that were effec tively demonstrated computationally and were consistent with experimental studies . However, in the case of model simulation of Wnt and EGF pathways, the model net work did not supply any concurrent results with experimental data despite the fac t that drugs were added at the appropriate positions. This paves insight into the potential of crosstalks between pathways considered in our study. Therefore, we manually developed a map of signaling crosstalk, which included the species conne cted by representatives from Notch, Shh, Wnt, and EGF pathways and highlighted th e regulation of a single target gene, Hes-1, based on drug-induced simulations. T hese simulations provided results that matched with experimental studies. Therefo re, these signaling crosstalk models complement as a tool toward the discovery of novel regulatory processes involved in neural stem cell maintenance, proliferati on, and differentiation during mammalian central nervous system development. To o ur knowledge, this is the first report of a simple crosstalk map that highlights the differential regulation of neural stem cell differentiation and underscores t he flow of positive and negative regulatory signals modulated by drugs. Note: EGFR belongs to the human epidermal receptor (HER) family of receptor tyrosine kinases, which consists of four closely related receptors (EGFR (HER1, erbB1), HER2 (neu, erbB2), HER3 (erbB3), and HER4 (erbB4)) that mediate cellular signaling pathways involved in growth and proliferation in response to the binding of a variety of growth factor ligands. There are currently six known endogenous ligands for EGFR: EGF, transforming growth factor- (TGF-), amphiregulin, betacellulin, heparin-binding EGF (HB-EGF), and epiregulin.Upon ligand binding, the EGFR forms homo- or heterodimeric complexes (usually with HER2), which leads to activation of the receptor tyrosine kinase, via autophosphorylation. References: 12813928 14527402 14561424 14766123 This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Long Name: GTP Synonym: Synonym not specified Accession: S01653
Long Name: 14-3-3 Synonym: PAR-5,Stratifin,protein kinase C inhibitor protein-1 (KCIP-1) Accession: P00539
Long Name: PKC Synonym: Synonym not specified Accession: P00565
Long Name: protein phosphatase 2A Synonym: Serine/threonine protein phosphatase 2A Accession: P00547
Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00551
Long Name: Raf-1 kinase inhibitor protein Synonym: Hippocampal cholinergic stimulatory peptide precursor,PEBP,Phosphatidylethanolamine-binding protein,Terminal flower 1,neuropolypeptide h3,prostastic binding protein Accession: P00548
Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00560
Long Name: Ras Synonym: Synonym not specified Accession: P00552
Long Name: Epidermal growth factor Synonym: gurken,transforming growth factor alpha Accession: P00549
Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase Accession: P00559
kinetics of non-modulated unireactant enzymes
Long Name: Mitogenesis Differentiation Synonym: Synonym not specified Accession: U02228
Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00543
mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
reversible rapid-equilibrium random order ternary-complex mechanism with one product
Long Name: GDP Synonym: Synonym not specified Accession: S01652
reversible rapid-equilibrium random order ternary-complex mechanism with two products