BIOMD0000000374
type: SBMLModel
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notes: This a model from the article: A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells. Bertram R, Smolen P, Sherman A, Mears D, Atwater I, Martin F, Soria B. Biophys J 1995 Jun;68(6):2323-32 7647236 , Abstract: S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Bertram R, Smolen P, Sherman A, Mears D, Atwater I, Martin F, Soria B. (1995) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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W3 CDTF: Thu Mar 08 12:51:27 GMT 2012

ORG:
  orgname: EMBL-EBI
n:
  given: Ishan
  family: Ajmera

W3 CDTF: Thu Sep 29 23:07:50 BST 2011

ORG:
  orgname: The University of Auckland,The Bioengineering Institute
n:
  given: Catherine
  family: Lloyd