BIOMD0000000371
type: SBMLModel
parameter: metaid_0000066
is: MODEL0911270002
rule: metaid_0000038
parameter: metaid_0000050
area units: 498119
parameter: metaid_0000052
length unit: length
rule: metaid_0000036
name: DeVries2000_PancreaticBetaCells_InsulinSecretion
compartment: metaid_0000031
modified:
  W3 CDTF: Thu Mar 08 12:39:46 GMT 2012
rule: metaid_0000041
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
parameter: metaid_0000029
parameter: metaid_0000046
parameter: metaid_0000047
parameter: metaid_0000053
species: metaid_0000044
parameter: metaid_0000054
substance units: 709238
parameter: metaid_0000056
rule: metaid_0000040
volume units: 498095
parameter: metaid_0000049
parameter: metaid_0000051
is described by: http://identifiers.org/pubmed/11093836
rule: metaid_0000035
parameter: metaid_0000057
parameter: metaid_0000061
parameter: metaid_0000063
parameter: metaid_0000058
parameter: metaid_0000030
rule: metaid_0000033
species: metaid_0000043
rule: metaid_0000037
parameter: metaid_0000048
parameter: metaid_0000060
parameter: metaid_0000055
parameter: metaid_0000065
rule: metaid_0000032
created:
  W3 CDTF: Wed Sep 28 22:16:51 BST 2011
rule: metaid_0000039
time units: 709214
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Ishan
    family: Ajmera
is version of: GO:0030073
rule: metaid_0000034
parameter: metaid_0000062
parameter: metaid_0000064
parameter: metaid_0000045
parameter: metaid_0000059
is version of: GO:0044342
species: metaid_0000042
notes: This a model from the article: Channel sharing in pancreatic beta -cells revisited: enhancement of emergent bursting by noise. De Vries G, Sherman A. J Theor Biol 2000 Dec 21;207(4):513-30 11093836 , Abstract: Secretion of insulin by electrically coupled populations of pancreatic beta -cells is governed by bursting electrical activity. Isolated beta -cells, however, exhibit atypical bursting or continuous spike activity. We study bursting as an emergent property of the population, focussing on interactions among the subclass of spiking cells. These are modelled by equipping the fast subsystem with a saddle-node-loop bifurcation, which makes it monostable. Such cells can only spike tonically or remain silent when isolated, but can be induced to burst with weak diffusive coupling. With stronger coupling, the cells revert to tonic spiking. We demonstrate that the addition of noise dramatically increases, via a phenomenon like stochastic resonance, the coupling range over which bursting is seen. Copyright 2000 Academic Press. This model was taken from the CellML repository and automatically converted to SBML. The original model was: De Vries G, Sherman A. (2000) - version01 This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
occurs in: http://identifiers.org/taxonomy/9606
curated: true
occurs in: BTO:0000783

metaid_0000066
type: Parameter
constant: false
value: 6.0
name: i_K_ATP

metaid_0000050
type: Parameter
is: SBO:0000009
constant: true
value: -20.0
name: V_m

metaid_0000052
type: Parameter
constant: false
value: 5.0
name: i_K

metaid_0000031
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: Compartment

metaid_0000029
type: Parameter
is: SBO:0000345
constant: true
value: 20000.0
name: tau_s

metaid_0000046
type: Parameter
constant: false
value: -7.4446678508483
name: i_Ca

metaid_0000047
type: Parameter
is: SBO:0000009
constant: true
value: 3.6
name: g_Ca

metaid_0000053
type: Parameter
is: SBO:0000009
constant: true
value: -75.0
name: V_K

metaid_0000044
type: Species
is: PATO:0001227
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.025
in compartment: metaid_0000031
name: s

metaid_0000054
type: Parameter
is: SBO:0000009
constant: true
value: 10.0
name: g_K

metaid_0000056
type: Parameter
is: SBO:0000009
constant: true
value: -17.0
name: V_n

metaid_0000049
type: Parameter
constant: false
value: 0.0229773699100256
name: m_infinity

metaid_0000051
type: Parameter
is: SBO:0000009
constant: true
value: 12.0
name: theta_m

metaid_0000057
type: Parameter
is: SBO:0000009
constant: true
value: 5.6
name: theta_n

metaid_0000061
type: Parameter
is: SBO:0000009
constant: true
value: 4.0
name: g_s

metaid_0000063
type: Parameter
is: SBO:0000009
constant: true
value: -22.0
name: V_s

metaid_0000058
type: Parameter
is: SBO:0000009
constant: true
value: 0.8
name: lamda

metaid_0000030
type: Parameter
constant: true
value: 1.2
name: g_K_ATP

metaid_0000043
type: Species
is version of: GO:0005251
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.05
in compartment: metaid_0000031
name: n

metaid_0000048
type: Parameter
is: SBO:0000009
constant: true
value: 25.0
name: V_Ca

metaid_0000060
type: Parameter
constant: false
value: 1.0
name: i_s

metaid_0000055
type: Parameter
constant: false
value: 1.89405943825186E-4
name: n_infinity

metaid_0000065
type: Parameter
is: SBO:0000009
constant: true
value: 0.5
name: p

metaid_0000062
type: Parameter
constant: false
value: 0.00460957217937421
name: s_infinity

metaid_0000064
type: Parameter
is: SBO:0000009
constant: true
value: 8.0
name: theta_s

metaid_0000045
type: Parameter
is: SBO:0000345
constant: true
value: 20.0
name: tau

metaid_0000059
type: Parameter
is: SBO:0000345
constant: true
value: 20.0
name: tau_2

metaid_0000042
type: Species
is: PATO:0001462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: -65.0
in compartment: metaid_0000031
name: V_membrane