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notes: This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE 2011; 6(7): e22038. doi:10.1371/journal.pone.0022038 , Abstract: Neurodegeneration is an age-related disorder which is characterised by the accumulation of aggregated protein and neuronal cell death. There are many different neurodegenerative diseases which are classified according to the specific proteins involved and the regions of the brain which are affected. Despite individual differences, there are common mechanisms at the sub-cellular level leading to loss of protein homeostasis. The two central systems in protein homeostasis are the chaperone system, which promotes correct protein folding, and the cellular proteolytic system, which degrades misfolded or damaged proteins. Since these systems and their interactions are very complex, we use mathematical modelling to aid understanding of the processes involved. The model developed in this study focuses on the role of Hsp70 (IPR00103) and Hsp90 (IPR001404) chaperones in preventing both protein aggregation and cell death. Simulations were performed under three different conditions: no stress; transient stress due to an increase in reactive oxygen species; and high stress due to sustained increases in reactive oxygen species. The model predicts that protein homeostasis can be maintained during short periods of stress. However, under long periods of stress, the chaperone system becomes overwhelmed and the probability of cell death pathways being activated increases. Simulations were also run in which cell death mediated by the JNK (P45983) and p38 (Q16539) pathways was inhibited. The model predicts that inhibiting either or both of these pathways may delay cell death but does not stop the aggregation process and that eventually cells die due to aggregated protein inhibiting proteasomal function. This problem can be overcome if the sequestration of aggregated protein …
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boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 490.0
in compartment: 840070

292988
type: SpeciesReference
stoichiometry: 1.0
species: 840085

840189
type: Reaction
product: 294258
reactant: 294246
reactant: 294234
is version of: GO:0009056
fast: false
kinetic law: 294282
is: SBO:0000179
product: 294270
reversible: false

294258
type: SpeciesReference
stoichiometry: 1.0
species: 840125

294246
type: SpeciesReference
stoichiometry: 1.0
species: 840132

294234
type: SpeciesReference
stoichiometry: 1.0
species: 840081

294270
type: SpeciesReference
stoichiometry: 1.0
species: 840134

840121
type: Species
is version of: IPR012233
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 100.0
in compartment: 840070

840171
type: Reaction
fast: false
product: 293630
reversible: false
is: SBO:0000216
product: 293618
reactant: 293606
kinetic law: 293642
is version of: GO:0016310
reactant: 293594

293630
type: SpeciesReference
stoichiometry: 1.0
species: 840121

293618
type: SpeciesReference
stoichiometry: 1.0
species: 840101

293606
type: SpeciesReference
stoichiometry: 1.0
species: 840121

293594
type: SpeciesReference
stoichiometry: 1.0
species: 840100

840170
type: Reaction
is: SBO:0000180
reactant: 293544
is version of: GO:0032986
fast: false
product: 293556
product: 293569
kinetic law: 293582
reversible: false

293544
type: SpeciesReference
stoichiometry: 1.0
species: 840109

293556
type: SpeciesReference
stoichiometry: 1.0
species: 840105

840105
type: Species
is: SBO:0000369
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 2.0
in compartment: 840071

293569
type: SpeciesReference
stoichiometry: 1.0
species: 840100

840204
type: Reaction
kinetic law: 294909
product: 294897
reactant: 294885
is version of: GO:0070841
is: SBO:0000177
fast: false
reversible: false

294897
type: SpeciesReference
stoichiometry: 1.0
species: 840127

294885
type: SpeciesReference
stoichiometry: 2.0
species: 840074

840398
type: Parameter
is: SBO:0000009
constant: true
value: 0.01

840240
type: Reaction
is version of: GO:0070841
reversible: false
reactant: 296226
reactant: 296238
product: 296250
kinetic law: 296262
fast: false
is: SBO:0000177

296226
type: SpeciesReference
stoichiometry: 1.0
species: 840079

296238
type: SpeciesReference
stoichiometry: 1.0
species: 840127

296250
type: SpeciesReference
stoichiometry: 1.0
species: 840129

840129
type: Species
is version of: CHEBI:36080
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070

840402
type: Parameter
is: SBO:0000009
constant: true
value: 0.02

840151
type: Reaction
reversible: false
is version of: GO:0070389
fast: false
is: SBO:0000180
product: 292831
product: 292843
reactant: 292819
kinetic law: 292855

292831
type: SpeciesReference
stoichiometry: 1.0
species: 840074

292843
type: SpeciesReference
stoichiometry: 1.0
species: 840075

292819
type: SpeciesReference
stoichiometry: 1.0
species: 840098

840098
type: Species
has only substance units: true
initial amount: 410.0
in compartment: 840070
initial concentration: NaN
is: SBO:0000297
boundary condition: false
has part: IPR001404
has part: CHEBI:36080
constant: false

840185
type: Reaction
kinetic law: 294125
product: 294113
reactant: 294101
is version of: GO:0006412
is: SBO:0000184
fast: false
reversible: false

294113
type: SpeciesReference
stoichiometry: 1.0
species: 840075

294101
type: SpeciesReference
stoichiometry: 1.0
species: 840135

840393
type: Parameter
is: SBO:0000009
constant: true
value: 0.05

840122
type: Species
is version of: Q16539
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 100.0
in compartment: 840070

840220
type: Reaction
is: SBO:0000180
kinetic law: 295502
product: 295478
fast: false
reactant: 295466
is version of: GO:0043241
reversible: false
product: 295490

295478
type: SpeciesReference
stoichiometry: 1.0
species: 840088

295466
type: SpeciesReference
stoichiometry: 1.0
species: 840093

840093
type: Species
boundary condition: false
is: SBO:0000297
has part: P31749
initial concentration: NaN
initial amount: 0.0
has only substance units: true
constant: false
has part: GO:0000502
in compartment: 840070

295490
type: SpeciesReference
stoichiometry: 1.0
species: 840125

840165
type: Reaction
kinetic law: 293385
product: 293373
reactant: 293361
is version of: GO:0043241
is: SBO:0000180
fast: false
reversible: false

293373
type: SpeciesReference
stoichiometry: 2.0
species: 840094

293361
type: SpeciesReference
stoichiometry: 1.0
species: 840102

840139
type: Species
is: SBO:0000236
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070

840416
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-8

840073
type: Species
is version of: CHEBI:36080
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 17600.0
in compartment: 840070

840237
type: Reaction
reactant: 296153
reactant: 296140
is version of: GO:0070841
product: 296165
reversible: false
is: SBO:0000177
kinetic law: 296177
fast: false

296153
type: SpeciesReference
stoichiometry: 1.0
species: 840127

296140
type: SpeciesReference
stoichiometry: 1.0
species: 840077

296165
type: SpeciesReference
stoichiometry: 1.0
species: 840129

840434
type: Parameter
constant: false
value: 0.0

840145
type: Reaction
reactant: 292542
product: 292579
is: SBO:0000344
product: 292567
kinetic law: 292591
is version of: GO:0000302
reversible: false
fast: false
reactant: 292555

292542
type: SpeciesReference
stoichiometry: 1.0
species: 840073

292579
type: SpeciesReference
stoichiometry: 1.0
species: 840131

292567
type: SpeciesReference
stoichiometry: 1.0
species: 840074

292555
type: SpeciesReference
stoichiometry: 1.0
species: 840131

840356
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-8

840217
type: Reaction
reversible: false
fast: false
product: 295358
is: SBO:0000526
reactant: 295346
kinetic law: 295382
product: 295370
is version of: GO:0043241

295358
type: SpeciesReference
stoichiometry: 1.0
species: 840090

295346
type: SpeciesReference
stoichiometry: 1.0
species: 840092

295370
type: SpeciesReference
stoichiometry: 1.0
species: 840089

840385
type: Parameter
is: SBO:0000009
constant: true
value: 0.001

840161
type: Reaction
kinetic law: 293252
product: 293240
reactant: 293228
is version of: GO:0042803
is: SBO:0000526
fast: false
reversible: false

293240
type: SpeciesReference
stoichiometry: 1.0
species: 840102

293228
type: SpeciesReference
stoichiometry: 2.0
species: 840094

840177
type: Reaction
is: SBO:0000526
kinetic law: 293848
fast: false
is version of: GO:0006461
reactant: 293812
reactant: 293824
product: 293836
reversible: false

293812
type: SpeciesReference
stoichiometry: 1.0
species: 840101

293824
type: SpeciesReference
stoichiometry: 1.0
species: 840105

293836
type: SpeciesReference
stoichiometry: 1.0
species: 840110

840164
type: Reaction
fast: false
product: 293337
is: SBO:0000180
reversible: false
kinetic law: 293349
product: 293325
is version of: GO:0070206
reactant: 293313

293337
type: SpeciesReference
stoichiometry: 1.0
species: 840102

293325
type: SpeciesReference
stoichiometry: 1.0
species: 840094

293313
type: SpeciesReference
stoichiometry: 1.0
species: 840100

840365
type: Parameter
is: SBO:0000009
constant: true
value: 0.5

840213
type: Reaction
is version of: GO:0006461
is: SBO:0000526
reactant: 295214
reversible: false
product: 295226
fast: false
reactant: 295202
kinetic law: 295238

295214
type: SpeciesReference
stoichiometry: 1.0
species: 840088

295226
type: SpeciesReference
stoichiometry: 1.0
species: 840089

295202
type: SpeciesReference
stoichiometry: 1.0
species: 840076

840233
type: Reaction
is: SBO:0000177
fast: false
reactant: 296019
is version of: GO:0006461
reversible: false
reactant: 296007
kinetic law: 296043
product: 296031

296019
type: SpeciesReference
stoichiometry: 1.0
species: 840125

296007
type: SpeciesReference
stoichiometry: 1.0
species: 840077

296031
type: SpeciesReference
stoichiometry: 1.0
species: 840081

840229
type: Reaction
is: SBO:0000393
fast: false
reversible: false
is version of: GO:0052064
kinetic law: 295875
product: 295863
reactant: 295839
product: 295851

295863
type: SpeciesReference
stoichiometry: 1.0
species: 840131

295839
type: SpeciesReference
stoichiometry: 1.0
species: 840123

295851
type: SpeciesReference
stoichiometry: 1.0
species: 840123

840196
type: Reaction
kinetic law: 294585
reactant: 294561
is: SBO:0000526
product: 294573
reactant: 294549
reversible: false
fast: false
is version of: GO:0006461

294561
type: SpeciesReference
stoichiometry: 1.0
species: 840114

840114
type: Species
is version of: GO:0008287
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070

294573
type: SpeciesReference
stoichiometry: 1.0
species: 840119

840119
type: Species
initial concentration: NaN
constant: false
has part: IPR001023
has only substance units: true
initial amount: 100.0
is: SBO:0000297
boundary condition: false
in compartment: 840070
has part: GO:0008287

294549
type: SpeciesReference
stoichiometry: 1.0
species: 840075

840144
type: Reaction
kinetic law: 292530
product: 292518
reactant: 292506
is version of: GO:0006412
is: SBO:0000284
fast: false
reversible: false

292518
type: SpeciesReference
stoichiometry: 1.0
species: 840073

292506
type: SpeciesReference
stoichiometry: 1.0
species: 840135

840410
type: Parameter
is: SBO:0000009
constant: true
value: 6.0E-8

840173
type: Reaction
fast: false
reversible: false
product: 293679
kinetic law: 293703
is version of: GO:0016311
reactant: 293654
is: SBO:0000330
product: 293691
reactant: 293667

293679
type: SpeciesReference
stoichiometry: 1.0
species: 840100

293654
type: SpeciesReference
stoichiometry: 1.0
species: 840101

293691
type: SpeciesReference
stoichiometry: 1.0
species: 840119

293667
type: SpeciesReference
stoichiometry: 1.0
species: 840119

840160
type: Reaction
is: SBO:0000180
is version of: GO:0032986
kinetic law: 293216
reactant: 293180
product: 293204
product: 293192
reversible: false
fast: false

293180
type: SpeciesReference
stoichiometry: 1.0
species: 840096

840096
type: Species
has part: IPR001404
is: SBO:0000297
constant: false
initial amount: 95.0
boundary condition: false
has only substance units: true
in compartment: 840070
initial concentration: NaN
has part: Q00613

293204
type: SpeciesReference
stoichiometry: 1.0
species: 840094

293192
type: SpeciesReference
stoichiometry: 1.0
species: 840076

840361
type: Parameter
is: SBO:0000009
constant: true
value: 8.0E-5

840427
type: Parameter
is: SBO:0000009
constant: true
value: 1.5E-7

ORG:
  orgname: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, UK
n:
  given: Carole J
  family: Proctor

840404
type: Parameter
is: SBO:0000009
constant: true
value: 0.05

840153
type: Reaction
is: SBO:0000526
kinetic law: 292976
product: 292964
reactant: 292952
is version of: GO:0006461
fast: false
reactant: 292940
reversible: false

292964
type: SpeciesReference
stoichiometry: 1.0
species: 840085

292952
type: SpeciesReference
stoichiometry: 1.0
species: 840082

292940
type: SpeciesReference
stoichiometry: 1.0
species: 840075

840225
type: Reaction
is version of: GO:0009056
kinetic law: 295707
reactant: 295671
product: 295695
reactant: 295659
product: 295683
reversible: false
fast: false
is: SBO:0000179

295671
type: SpeciesReference
stoichiometry: 1.0
species: 840132

295695
type: SpeciesReference
stoichiometry: 1.0
species: 840134

295659
type: SpeciesReference
stoichiometry: 1.0
species: 840118

295683
type: SpeciesReference
stoichiometry: 1.0
species: 840125

840156
type: Reaction
product: 293060
reactant: 293036
reversible: false
reactant: 293048
kinetic law: 293072
is: SBO:0000526
fast: false
is version of: GO:0006461

293060
type: SpeciesReference
stoichiometry: 1.0
species: 840086

293036
type: SpeciesReference
stoichiometry: 1.0
species: 840076

293048
type: SpeciesReference
stoichiometry: 1.0
species: 840084

840422
type: Parameter
is: SBO:0000009
constant: true
value: 0.001

840205
type: Reaction
reactant: 294933
reactant: 294921
reversible: false
fast: false
product: 294945
is: SBO:0000177
is version of: GO:0051235
kinetic law: 294957

294933
type: SpeciesReference
stoichiometry: 1.0
species: 840127

294921
type: SpeciesReference
stoichiometry: 1.0
species: 840074

294945
type: SpeciesReference
stoichiometry: 1.0
species: 840129

840239
type: Reaction
kinetic law: 296214
product: 296202
reactant: 296189
is version of: GO:0070841
is: SBO:0000177
fast: false
reversible: false

296202
type: SpeciesReference
stoichiometry: 1.0
species: 840127

296189
type: SpeciesReference
stoichiometry: 2.0
species: 840079

840373
type: Parameter
is: SBO:0000009
constant: true
value: 0.08

840418
type: Parameter
is: SBO:0000009
constant: true
value: 9.6E-9

840390
type: Parameter
is: SBO:0000009
constant: false
value: 5.0

840241
type: Reaction
reversible: false
product: 296298
is: SBO:0000177
kinetic law: 296310
is version of: GO:0051235
reactant: 296274
reactant: 296286
fast: false

296298
type: SpeciesReference
stoichiometry: 2.0
species: 840129

296274
type: SpeciesReference
stoichiometry: 1.0
species: 840077

296286
type: SpeciesReference
stoichiometry: 1.0
species: 840129

W3 CDTF: Thu Jul 21 17:40:43 BST 2011

840152
type: Reaction
kinetic law: 292928
is: SBO:0000344
reversible: false
fast: false
reactant: 292867
product: 292904
reactant: 292879
product: 292916
is version of: GO:0070389
product: 292891

292867
type: SpeciesReference
stoichiometry: 1.0
species: 840098

292904
type: SpeciesReference
stoichiometry: 1.0
species: 840073

292879
type: SpeciesReference
stoichiometry: 1.0
species: 840132

292916
type: SpeciesReference
stoichiometry: 1.0
species: 840134

292891
type: SpeciesReference
stoichiometry: 1.0
species: 840075

840186
type: Reaction
fast: false
reactant: 294137
kinetic law: 294174
product: 294149
is version of: GO:0032092
is: SBO:0000177
reversible: false
product: 294162

294137
type: SpeciesReference
stoichiometry: 1.0
species: 840107

294149
type: SpeciesReference
stoichiometry: 1.0
species: 840107

294162
type: SpeciesReference
stoichiometry: 1.0
species: 840075

840219
type: Reaction
is version of: GO:0070628
kinetic law: 295454
reactant: 295394
fast: false
reversible: false
reactant: 295406
product: 295430
product: 295418
is: SBO:0000177
product: 295442

295394
type: SpeciesReference
stoichiometry: 1.0
species: 840092

295406
type: SpeciesReference
stoichiometry: 1.0
species: 840125

295430
type: SpeciesReference
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species: 840090

295418
type: SpeciesReference
stoichiometry: 1.0
species: 840093

295442
type: SpeciesReference
stoichiometry: 1.0
species: 840076

840353
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-7

840369
type: Parameter
is: SBO:0000009
constant: true
value: 0.5

840394
type: Parameter
is: SBO:0000009
constant: true
value: 0.2

840201
type: Reaction
reactant: 294765
product: 294801
reversible: false
reactant: 294777
product: 294789
kinetic law: 294813
is version of: GO:0016310
is: SBO:0000216
fast: false

294765
type: SpeciesReference
stoichiometry: 1.0
species: 840131

294801
type: SpeciesReference
stoichiometry: 1.0
species: 840123

294777
type: SpeciesReference
stoichiometry: 1.0
species: 840122

294789
type: SpeciesReference
stoichiometry: 1.0
species: 840131

840147
type: Reaction
product: 292675
kinetic law: 292687
reactant: 292651
reversible: false
is version of: GO:0070389
product: 292663
fast: false
is: SBO:0000180

292675
type: SpeciesReference
stoichiometry: 1.0
species: 840076

292651
type: SpeciesReference
stoichiometry: 1.0
species: 840097

292663
type: SpeciesReference
stoichiometry: 1.0
species: 840074

840221
type: Reaction
kinetic law: 295563
reactant: 295514
product: 295551
fast: false
reactant: 295526
product: 295539
is version of: GO:0009056
reversible: false
is: SBO:0000179

295514
type: SpeciesReference
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species: 840093

295551
type: SpeciesReference
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species: 840134

295526
type: SpeciesReference
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species: 840132

295539
type: SpeciesReference
stoichiometry: 1.0
species: 840125

840417
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-5

840166
type: Reaction
reactant: 293409
fast: false
is version of: GO:0006461
reversible: false
is: SBO:0000526
reactant: 293397
kinetic law: 293433
product: 293421

293409
type: SpeciesReference
stoichiometry: 1.0
species: 840103

293397
type: SpeciesReference
stoichiometry: 1.0
species: 840100

293421
type: SpeciesReference
stoichiometry: 1.0
species: 840106

840179
type: Reaction
kinetic law: 293933
product: 293921
reactant: 293908
is version of: GO:0006412
is: SBO:0000184
fast: false
reversible: false

293921
type: SpeciesReference
stoichiometry: 1.0
species: 840076

293908
type: SpeciesReference
stoichiometry: 1.0
species: 840135

840215
type: Reaction
product: 295274
is version of: GO:0043241
reactant: 295250
kinetic law: 295286
is: SBO:0000180
reversible: false
fast: false
product: 295262

295274
type: SpeciesReference
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species: 840076

295250
type: SpeciesReference
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species: 840089

295262
type: SpeciesReference
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species: 840088

840190
type: Reaction
product: 294318
kinetic law: 294342
product: 294330
is: SBO:0000177
reversible: false
reactant: 294306
fast: false
reactant: 294294
is version of: GO:0070628

294318
type: SpeciesReference
stoichiometry: 1.0
species: 840126

840126
type: Species
in compartment: 840070
initial concentration: NaN
has part: GO:0000502
has part: CHEBI:36080
has only substance units: true
initial amount: 0.0
is: SBO:0000297
boundary condition: false
constant: false

294330
type: SpeciesReference
stoichiometry: 1.0
species: 840075

294306
type: SpeciesReference
stoichiometry: 1.0
species: 840125

294294
type: SpeciesReference
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species: 840098

840435
type: Parameter
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value: 0.0

840198
type: Reaction
product: 294609
fast: false
is version of: GO:0043241
reversible: false
kinetic law: 294633
reactant: 294597
product: 294621
is: SBO:0000180

294609
type: SpeciesReference
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species: 840075

294597
type: SpeciesReference
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species: 840119

294621
type: SpeciesReference
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species: 840114

840412
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-8

840386
type: Parameter
is: SBO:0000009
constant: true
value: 2.0E-4

840159
type: Reaction
fast: false
reactant: 293144
reactant: 293132
kinetic law: 293168
reversible: false
is: SBO:0000526
product: 293156
is version of: GO:0006461

293144
type: SpeciesReference
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species: 840094

293132
type: SpeciesReference
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species: 840076

293156
type: SpeciesReference
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species: 840096

840178
type: Reaction
reactant: 293860
product: 293884
is version of: GO:0032986
reversible: false
product: 293872
is: SBO:0000180
fast: false
kinetic law: 293896

293860
type: SpeciesReference
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species: 840110

293884
type: SpeciesReference
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species: 840105

293872
type: SpeciesReference
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species: 840101

840231
type: Reaction
is: SBO:0000177
product: 295923
is version of: GO:0006974
fast: false
reactant: 295887
reversible: false
reactant: 295899
product: 295911
kinetic law: 295935

295923
type: SpeciesReference
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species: 840131

295887
type: SpeciesReference
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species: 840075

295899
type: SpeciesReference
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species: 840131

295911
type: SpeciesReference
stoichiometry: 1.0
species: 840077

840381
type: Parameter
is: SBO:0000009
constant: true
value: 0.01

840227
type: Reaction
product: 295755
fast: false
is version of: GO:0016310
kinetic law: 295767
product: 295743
reversible: false
reactant: 295731
reactant: 295719
is: SBO:0000216

295755
type: SpeciesReference
stoichiometry: 1.0
species: 840075

295743
type: SpeciesReference
stoichiometry: 1.0
species: 840117

295731
type: SpeciesReference
stoichiometry: 1.0
species: 840075

295719
type: SpeciesReference
stoichiometry: 1.0
species: 840115

840211
type: Reaction
kinetic law: 295153
reactant: 295114
fast: false
product: 295129
is version of: GO:0052064
reversible: false
is: SBO:0000393
product: 295141

295114
type: SpeciesReference
stoichiometry: 1.0
species: 840130

295129
type: SpeciesReference
stoichiometry: 1.0
species: 840130

295141
type: SpeciesReference
stoichiometry: 1.0
species: 840131

840174
type: Reaction
reactant: 293716
fast: false
is version of: GO:0006461
reversible: false
reactant: 293728
product: 293740
is: SBO:0000526
kinetic law: 293752

293716
type: SpeciesReference
stoichiometry: 1.0
species: 840101

293728
type: SpeciesReference
stoichiometry: 1.0
species: 840103

293740
type: SpeciesReference
stoichiometry: 1.0
species: 840107

840207
type: Reaction
fast: false
reactant: 294981
reversible: false
is: SBO:0000177
product: 294993
kinetic law: 295005
reactant: 294969
is version of: GO:0090261

294981
type: SpeciesReference
stoichiometry: 1.0
species: 840074

294993
type: SpeciesReference
stoichiometry: 2.0
species: 840129

294969
type: SpeciesReference
stoichiometry: 1.0
species: 840129

840357
type: Parameter
is: SBO:0000009
constant: true
value: 7.0E-7

840362
type: Parameter
is: SBO:0000009
constant: true
value: 5.5E-4

840169
type: Reaction
fast: false
product: 293519
kinetic law: 293532
reversible: false
is version of: GO:0006461
is: SBO:0000526
reactant: 293494
reactant: 293507

293519
type: SpeciesReference
stoichiometry: 1.0
species: 840109

293494
type: SpeciesReference
stoichiometry: 1.0
species: 840100

293507
type: SpeciesReference
stoichiometry: 1.0
species: 840105

840243
type: Reaction
reversible: false
kinetic law: 296358
is: SBO:0000177
product: 296346
is version of: GO:0051235
reactant: 296334
reactant: 296322
fast: false

296346
type: SpeciesReference
stoichiometry: 2.0
species: 840129

296334
type: SpeciesReference
stoichiometry: 1.0
species: 840129

296322
type: SpeciesReference
stoichiometry: 1.0
species: 840079

840405
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-6

840396
type: Parameter
is: SBO:0000009
constant: true
value: 5.0

840203
type: Reaction
kinetic law: 294873
is: SBO:0000330
product: 294849
product: 294861
reversible: false
is version of: GO:0016311
reactant: 294837
reactant: 294825
fast: false

294849
type: SpeciesReference
stoichiometry: 1.0
species: 840122

294861
type: SpeciesReference
stoichiometry: 1.0
species: 840117

294837
type: SpeciesReference
stoichiometry: 1.0
species: 840117

294825
type: SpeciesReference
stoichiometry: 1.0
species: 840123

840423
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-4

840400
type: Parameter
is: SBO:0000009
constant: true
value: 0.1

840389
type: Parameter
is: SBO:0000009
constant: true
value: 2.0E-4

840374
type: Parameter
is: SBO:0000009
constant: true
value: 0.2

840150
type: Reaction
is: SBO:0000526
kinetic law: 292807
reactant: 292771
is version of: GO:0051087
product: 292795
reactant: 292783
reversible: false
fast: false

292771
type: SpeciesReference
stoichiometry: 1.0
species: 840074

292795
type: SpeciesReference
stoichiometry: 1.0
species: 840098

292783
type: SpeciesReference
stoichiometry: 1.0
species: 840075

840193
type: Reaction
is: SBO:0000179
is version of: GO:0009056
reactant: 294414
reversible: false
reactant: 294426
kinetic law: 294463
fast: false
product: 294438
product: 294451

294414
type: SpeciesReference
stoichiometry: 1.0
species: 840126

294426
type: SpeciesReference
stoichiometry: 1.0
species: 840132

294438
type: SpeciesReference
stoichiometry: 1.0
species: 840125

294451
type: SpeciesReference
stoichiometry: 1.0
species: 840134

840351
type: Parameter
is: SBO:0000009
constant: true
value: 0.042

840419
type: Parameter
is: SBO:0000009
constant: true
value: 0.01

840392
type: Parameter
is: SBO:0000009
constant: true
value: 0.02

840354
type: Parameter
is: SBO:0000009
constant: true
value: 0.01

840148
type: Reaction
product: 292723
fast: false
reversible: false
is: SBO:0000344
product: 292747
reactant: 292711
product: 292735
kinetic law: 292759
is version of: GO:0070389
reactant: 292699

292723
type: SpeciesReference
stoichiometry: 1.0
species: 840076

292747
type: SpeciesReference
stoichiometry: 1.0
species: 840134

292711
type: SpeciesReference
stoichiometry: 1.0
species: 840132

292735
type: SpeciesReference
stoichiometry: 1.0
species: 840073

292699
type: SpeciesReference
stoichiometry: 1.0
species: 840097

840433
type: Parameter
constant: false
value: 0.0

840191
type: Reaction
kinetic law: 294402
product: 294390
fast: false
reversible: false
reactant: 294354
is: SBO:0000177
reactant: 294366
is version of: GO:0070628
product: 294378

294390
type: SpeciesReference
stoichiometry: 1.0
species: 840076

294354
type: SpeciesReference
stoichiometry: 1.0
species: 840097

294366
type: SpeciesReference
stoichiometry: 1.0
species: 840125

294378
type: SpeciesReference
stoichiometry: 1.0
species: 840126

840408
type: Parameter
is: SBO:0000009
constant: true
value: 3.7E-4

840157
type: Reaction
fast: false
reactant: 293084
is version of: GO:0032986
product: 293108
reversible: false
product: 293096
is: SBO:0000180
kinetic law: 293120

293084
type: SpeciesReference
stoichiometry: 1.0
species: 840086

293108
type: SpeciesReference
stoichiometry: 1.0
species: 840084

293096
type: SpeciesReference
stoichiometry: 1.0
species: 840076

840413
type: Parameter
is: SBO:0000009
constant: true
value: 0.01

840364
type: Parameter
is: SBO:0000009
constant: false
value: 0.02

840209
type: Reaction
reversible: false
is: SBO:0000393
kinetic law: 295102
product: 295077
is version of: GO:0052064
fast: false
product: 295090
reactant: 295065

295077
type: SpeciesReference
stoichiometry: 1.0
species: 840127

295090
type: SpeciesReference
stoichiometry: 1.0
species: 840131

295065
type: SpeciesReference
stoichiometry: 1.0
species: 840127

840377
type: Parameter
is: SBO:0000009
constant: true
value: 0.008

840382
type: Parameter
is: SBO:0000009
constant: true
value: 0.01

840245
type: Reaction
product: 296442
fast: false
is version of: GO:0008219
kinetic law: 296478
reversible: false
is: SBO:0000179
reactant: 296430
product: 296454
product: 296466

296442
type: SpeciesReference
stoichiometry: 1.0
species: 840113

296430
type: SpeciesReference
stoichiometry: 1.0
species: 840113

296454
type: SpeciesReference
stoichiometry: 1.0
species: 840139

296466
type: SpeciesReference
stoichiometry: 1.0
species: 840142

840425
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-8

840200
type: Reaction
kinetic law: 294753
reactant: 294705
reversible: false
is: SBO:0000330
fast: false
product: 294729
is version of: GO:0016311
product: 294741
reactant: 294717

294705
type: SpeciesReference
stoichiometry: 1.0
species: 840113

294729
type: SpeciesReference
stoichiometry: 1.0
species: 840111

294741
type: SpeciesReference
stoichiometry: 1.0
species: 840117

294717
type: SpeciesReference
stoichiometry: 1.0
species: 840117

840376
type: Parameter
is: SBO:0000009
constant: true
value: 0.008

840358
type: Parameter
is: SBO:0000009
constant: true
value: 1.0E-5

840421
type: Parameter
is: SBO:0000009
constant: true
value: 0.02

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

W3 CDTF: Fri Apr 20 22:44:33 BST 2012