BIOMD0000000342
type: SBMLModel
units def: volume
reaction: re19
reaction: re25
parameter: totalNumLRC
units def: time
parameter: kon Smads
parameter: kpho Smad2
units def: area
species: PSmad2 PSmad2 c
units def: length
event: single pulse stimulation
species: LRC surf
species: PSmad2 Smad4 c
rule: CDMT00109
parameter: kdepho Smad2
compartment: default
parameter: kdeg T1R
length unit: length
rule: CDMT00110
units def: third order
parameter: kimp Smads
reaction: re17
species: PSmad2c
parameter: koff Smads
reaction: re8
reaction: re9
parameter: k T2R
parameter: kdiss LRC
reaction: re2
reaction: re23
time units: time
substance units: substance
units def: nM per min
parameter: kdeg TGF beta
rule: CDMT00106
reaction: re22
reaction: re28
compartment: Vnuc
parameter: KD ns
parameter: kexp Smad4
compartment: Vmed
parameter: totalSmad2n
reaction: re10
parameter: stimulation type
reaction: re15
reaction: re16
parameter: totalSmad2c
parameter: kimp Smad4
reaction: re6
parameter: kexp Smad2
reaction: re7
species: AA
species: Smad4n
is: MODEL1104050000
reaction: re18
parameter: kdeg LRC
occurs in: http://identifiers.org/taxonomy/9606
parameter: kdeg T2R
rule: CDMT00112
rule: CDMT00115
rule: CDMT00111
is described by: http://identifiers.org/pubmed/21613981
area units: area
species: Smad4c
parameter: totalNumPSmad2
species: TGF beta ex
species: T2R endo
species: LRC endo
parameter: k T1R
parameter: totalNumT1R
species: T2R surf
parameter: kr
species: PSmad2 Smad4 n
species: PSmad2 PSmad2 n
is part of: REACT 6844
species: TGF beta ns
reaction: re21
reaction: re1
rule: CDMT00107

volume
type: SBMLUnitsDef
unit: CDMT00097
name: volume

CDMT00097
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

re19
type: Reaction
kinetic law: CDMT00063
product: CDMT00062
reactant: CDMT00061
is version of: GO:0051169
fast: false
reversible: false
name: PSmad2 nuclear import

CDMT00062
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2n

PSmad2n
type: Species
constant: false
initial amount: NaN
has only substance units: false
is version of: C00562
initial concentration: 0.0
name: PSmad2n
is: SBO:0000252
substance units: nM
boundary condition: false
in compartment: Vnuc
is version of: Q15796

nM
type: SBMLUnitsDef
unit: CDMT00104
name: nanomolar

CDMT00104
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

Vnuc
type: Compartment
is version of: GO:0005634
is: SBO:0000290
constant: true
units: volume
size: 1.0E-12
spatial dimensions: 3.0
name: Nucleus

CDMT00061
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2c

PSmad2c
type: Species
initial concentration: 0.0
has only substance units: false
is version of: Q15796
boundary condition: false
is: SBO:0000252
name: PSmad2c
initial amount: NaN
is version of: C00562
substance units: nM
in compartment: Vcyt
constant: false

Vcyt
type: Compartment
is version of: GO:0005737
is: SBO:0000290
constant: true
units: volume
size: 2.3E-12
spatial dimensions: 3.0
name: Cytoplasm

re25
type: Reaction
kinetic law: CDMT00083
product: CDMT00082
reactant: CDMT00081
is version of: GO:0006461
fast: false
reversible: true
name: PSmad2 dimer formation

CDMT00082
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 PSmad2 c

PSmad2 PSmad2 c
type: Species
has part: Q15796
is: SBO:0000286
initial amount: NaN
boundary condition: false
has only substance units: false
name: PSmad2_PSmad2_c
in compartment: Vcyt
initial concentration: 0.0
is version of: C00562
constant: false
substance units: nM

CDMT00081
type: SpeciesReference
stoichiometry: 2.0
species: PSmad2c

totalNumLRC
type: Parameter
constant: false
units: mol per cell
value: 0.0

mol per cell
type: SBMLUnitsDef
unit: CDMT00117
name: molecules per cell

CDMT00117
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

time
type: SBMLUnitsDef
unit: CDMT00100
name: min

CDMT00100
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

kon Smads
type: Parameter
constant: true
units: second order
value: 0.198472

second order
type: SBMLUnitsDef
unit: CDMT00137
unit: CDMT00136
name: second order rate constant

CDMT00137
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

CDMT00136
type: SBMLUnit
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE

kpho Smad2
type: Parameter
constant: true
units: second order
value: 0.0488268

area
type: SBMLUnitsDef
unit: CDMT00098
name: area

CDMT00098
type: SBMLUnit
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE

length
type: SBMLUnitsDef
unit: CDMT00099
name: length

CDMT00099
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE

single pulse stimulation
type: Event
event assignment: CDMT00128
delay: CDMT00125
trigger: CDMT00124
use values from trigger time: true
name: TGF-beta washout in singel pulse stimulation

TGF beta ex
type: Species
name: TGF_beta_ex
is version of: P01137
initial concentration: 0.05
initial amount: NaN
in compartment: Vmed
occurs in: BTO:0000316
constant: false
is: SBO:0000252
substance units: nM
has only substance units: false
boundary condition: false

Vmed
type: Compartment
is version of: BTO:0000316
is: SBO:0000290
constant: false
units: volume
size: 2.0E-9
spatial dimensions: 3.0
name: Medium

CDMT00124
type: Trigger
persistant: true
initial value: true

LRC surf
type: Species
has only substance units: false
has part: P36897
initial amount: NaN
constant: false
name: LRC_surf
is version of: GO:0043235
is: SBO:0000297
has part: P01137
has part: P37173
occurs in: GO:0009986
boundary condition: false
initial concentration: 0.0
substance units: nM
in compartment: Vcyt

PSmad2 Smad4 c
type: Species
has part: Q15796
initial concentration: 0.0
is version of: C00562
constant: false
in compartment: Vcyt
substance units: nM
initial amount: NaN
name: PSmad2_Smad4_c
boundary condition: false
has part: Q13485
is: SBO:0000297
has only substance units: false

kdepho Smad2
type: Parameter
constant: true
units: per min
value: 0.394

per min
type: SBMLUnitsDef
unit: CDMT00101
name: per min

CDMT00101
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

default
type: Compartment
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0

kdeg T1R
type: Parameter
constant: true
units: per min
value: 0.00256

third order
type: SBMLUnitsDef
unit: CDMT00114
unit: CDMT00113
name: third order rate constant

CDMT00114
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

CDMT00113
type: SBMLUnit
exponent: -2.0
scale: -9
multipler: 1.0
kind: MOLE

kimp Smads
type: Parameter
constant: true
units: per min
value: 0.889

re17
type: Reaction
kinetic law: CDMT00056
product: CDMT00055
reactant: CDMT00054
is version of: GO:0051169
fast: false
reversible: false
name: Smad4 nuclear export

CDMT00055
type: SpeciesReference
stoichiometry: 1.0
species: Smad4c

Smad4c
type: Species
name: Smad4c
in compartment: Vcyt
boundary condition: false
is: SBO:0000252
is version of: Q13485
initial concentration: 50.8
initial amount: NaN
has only substance units: false
substance units: nM
constant: false

CDMT00054
type: SpeciesReference
stoichiometry: 1.0
species: Smad4n

Smad4n
type: Species
is version of: Q13485
substance units: nM
boundary condition: false
initial amount: NaN
has only substance units: false
name: Smad4n
in compartment: Vnuc
constant: false
initial concentration: 50.8
is: SBO:0000252

koff Smads
type: Parameter
constant: true
units: per min
value: 1.0

re8
type: Reaction
kinetic law: CDMT00025
product: CDMT00024
reactant: CDMT00023
is version of: GO:0032801
fast: false
reversible: false
name: T2R constitutive degradation

CDMT00024
type: SpeciesReference
stoichiometry: 1.0
species: empty degraded

empty degraded
type: Species
initial concentration: 0.0
has only substance units: false
boundary condition: true
in compartment: Vcyt
name: empty_degraded
constant: true
substance units: nM
is: SBO:0000291
initial amount: NaN

CDMT00023
type: SpeciesReference
stoichiometry: 1.0
species: T2R endo

T2R endo
type: Species
is: SBO:0000244
in compartment: Vcyt
name: T2R_endo
initial concentration: 1.43997
has only substance units: false
constant: false
is version of: P37173
substance units: nM
boundary condition: false
encodes: GO:0005769
initial amount: NaN

re9
type: Reaction
reversible: false
kinetic law: CDMT00030
reactant: CDMT00028
reactant: CDMT00026
name: LRC activation
reactant: CDMT00027
fast: false
product: CDMT00029
is version of: GO:0005102

CDMT00028
type: SpeciesReference
stoichiometry: 1.0
species: T1R surf

T1R surf
type: Species
occurs in: GO:0009986
in compartment: Vcyt
boundary condition: false
initial amount: NaN
substance units: nM
constant: false
is: SBO:0000244
name: T1R_surf
initial concentration: 0.702494
has only substance units: false
is version of: P36897

CDMT00026
type: SpeciesReference
stoichiometry: 1.0
species: TGF beta ex

CDMT00027
type: SpeciesReference
stoichiometry: 1.0
species: T2R surf

T2R surf
type: Species
boundary condition: false
is: SBO:0000244
name: T2R_surf
has only substance units: false
constant: false
occurs in: GO:0009986
initial amount: NaN
initial concentration: 0.201077
is version of: P37173
in compartment: Vcyt
substance units: nM

CDMT00029
type: SpeciesReference
stoichiometry: 1.0
species: LRC surf

k T2R
type: Parameter
constant: true
units: nM per min
value: 0.0190076

nM per min
type: SBMLUnitsDef
unit: CDMT00103
unit: CDMT00102
name: nM per min

CDMT00103
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

CDMT00102
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

kdiss LRC
type: Parameter
constant: true
units: per min
value: 0.0438111

re2
type: Reaction
kinetic law: CDMT00007
product: CDMT00006
reactant: CDMT00005
is version of: GO:0031623
fast: false
reversible: false
name: T1R internalization to early endosome

CDMT00006
type: SpeciesReference
stoichiometry: 1.0
species: T1R endo

T1R endo
type: Species
initial concentration: 6.52344
is: SBO:0000244
occurs in: GO:0005769
is version of: P36897
constant: false
name: T1R_endo
in compartment: Vcyt
substance units: nM
initial amount: NaN
has only substance units: false
boundary condition: false

CDMT00005
type: SpeciesReference
stoichiometry: 1.0
species: T1R surf

re23
type: Reaction
kinetic law: CDMT00077
product: CDMT00076
product: CDMT00075
reactant: CDMT00074
is version of: GO:0051169
fast: false
reversible: true
name: Smad2-Smad4 dissociation

CDMT00076
type: SpeciesReference
stoichiometry: 1.0
species: Smad4n

CDMT00075
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2n

CDMT00074
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 Smad4 n

PSmad2 Smad4 n
type: Species
name: PSmad2_Smad4_n
is: SBO:0000297
initial concentration: 0.0
has only substance units: false
substance units: nM
constant: false
has part: Q15796
has version: C00562
initial amount: NaN
boundary condition: false
has part: Q13485
in compartment: Vnuc

substance
type: SBMLUnitsDef
unit: CDMT00096
name: substance

CDMT00096
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

kdeg TGF beta
type: Parameter
constant: true
units: per min
value: 0.347

re22
type: Reaction
kinetic law: CDMT00073
product: CDMT00072
reactant: CDMT00071
fast: false
reversible: false
name: Smad2-Smad4 nuclear import

CDMT00072
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 Smad4 n

CDMT00071
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 Smad4 c

re28
type: Reaction
kinetic law: CDMT00095
product: CDMT00094
reactant: CDMT00093
is version of: GO:0009057
fast: false
reversible: false
name: negative feedback induced LRC degradation

CDMT00094
type: SpeciesReference
stoichiometry: 1.0
species: empty degraded

CDMT00093
type: SpeciesReference
stoichiometry: 1.0
species: LRC surf

KD ns
type: Parameter
constant: true
units: dimensionless
value: 40.2257

kexp Smad4
type: Parameter
constant: true
units: per min
value: 0.359

totalSmad2n
type: Parameter
constant: false
units: nM
value: 28.5

re10
type: Reaction
kinetic law: CDMT00033
product: CDMT00032
reactant: CDMT00031
is version of: GO:0031623
fast: false
reversible: false
name: LRC internalization to early endosome

CDMT00032
type: SpeciesReference
stoichiometry: 1.0
species: LRC endo

LRC endo
type: Species
has part: P01137
boundary condition: false
initial amount: NaN
has only substance units: false
in compartment: Vcyt
name: LRC_endo
is version of: GO:0043235
initial concentration: 0.0
has part: P36897
constant: false
occurs in: GO:0005769
has part: P37173
is: SBO:0000297
substance units: nM

CDMT00031
type: SpeciesReference
stoichiometry: 1.0
species: LRC surf

stimulation type
type: Parameter
constant: true
units: dimensionless
value: 1.0

re15
type: Reaction
kinetic law: CDMT00050
product: CDMT00049
reactant: CDMT00048
is version of: GO:0051169
fast: false
reversible: false
name: Smad2 nuclear export

CDMT00049
type: SpeciesReference
stoichiometry: 1.0
species: Smad2c

Smad2c
type: Species
name: Smad2c
boundary condition: false
substance units: nM
initial concentration: 60.6
in compartment: Vcyt
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is version of: Q15796

CDMT00048
type: SpeciesReference
stoichiometry: 1.0
species: Smad2n

Smad2n
type: Species
is version of: Q15796
in compartment: Vnuc
is: SBO:0000252
substance units: nM
boundary condition: false
initial concentration: 28.5
constant: false
initial amount: NaN
has only substance units: false
name: Smad2n

re16
type: Reaction
kinetic law: CDMT00053
product: CDMT00052
reactant: CDMT00051
is version of: GO:0051169
fast: false
reversible: false
name: Smad4 nuclear import

CDMT00052
type: SpeciesReference
stoichiometry: 1.0
species: Smad4n

CDMT00051
type: SpeciesReference
stoichiometry: 1.0
species: Smad4c

totalSmad2c
type: Parameter
constant: false
units: nM
value: 60.6

kimp Smad4
type: Parameter
constant: true
units: per min
value: 0.156

re6
type: Reaction
kinetic law: CDMT00019
product: CDMT00018
reactant: CDMT00017
is version of: GO:0031623
fast: false
reversible: false
name: T2R internalization to early endosome

CDMT00018
type: SpeciesReference
stoichiometry: 1.0
species: T2R endo

CDMT00017
type: SpeciesReference
stoichiometry: 1.0
species: T2R surf

kexp Smad2
type: Parameter
constant: true
units: per min
value: 0.763

re7
type: Reaction
kinetic law: CDMT00022
product: CDMT00021
reactant: CDMT00020
is version of: GO:0032456
fast: false
reversible: false
name: T2R recycling from early endosome

CDMT00021
type: SpeciesReference
stoichiometry: 1.0
species: T2R surf

CDMT00020
type: SpeciesReference
stoichiometry: 1.0
species: T2R endo

AA
type: Species
is: SBO:0000291
in compartment: Vcyt
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: 0.0
substance units: nM
constant: true
name: AA

re18
type: Reaction
kinetic law: CDMT00060
modifier: CDMT00059
product: CDMT00058
reactant: CDMT00057
is version of: GO:0006468
fast: false
reversible: false
name: Smad2 phosphorylation

CDMT00058
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2c

CDMT00057
type: SpeciesReference
stoichiometry: 1.0
species: Smad2c

kdeg LRC
type: Parameter
constant: true
units: per min
value: 0.00256

kdeg T2R
type: Parameter
constant: true
units: per min
value: 0.0132

totalNumPSmad2
type: Parameter
constant: false
units: mol per cell
value: 0.0

k T1R
type: Parameter
constant: true
units: nM per min
value: 0.0167

totalNumT1R
type: Parameter
constant: false
units: mol per cell
value: 10005.0

kr
type: Parameter
constant: true
units: per min
value: 0.0333

PSmad2 PSmad2 n
type: Species
initial amount: NaN
has only substance units: false
has part: Q15796
in compartment: Vnuc
initial concentration: 0.0
is version of: C00562
constant: false
boundary condition: false
name: PSmad2_PSmad2_n
is: SBO:0000286
substance units: nM

TGF beta ns
type: Species
initial concentration: 0.0
has only substance units: false
in compartment: Vmed
name: TGF_beta_ns
constant: false
boundary condition: false
is version of: P01137
is: SBO:0000252
substance units: nM
initial amount: NaN

re21
type: Reaction
kinetic law: CDMT00070
product: CDMT00069
reactant: CDMT00068
reactant: CDMT00067
is version of: GO:0006461
fast: false
reversible: true
name: Smad2-Smad4 complex formation

CDMT00069
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 Smad4 c

CDMT00068
type: SpeciesReference
stoichiometry: 1.0
species: Smad4c

CDMT00067
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2c

re1
type: Reaction
kinetic law: CDMT00004
product: CDMT00003
reactant: CDMT00002
is version of: GO:0032800
fast: false
reversible: false
name: T1R production

CDMT00003
type: SpeciesReference
stoichiometry: 1.0
species: T1R surf

CDMT00002
type: SpeciesReference
stoichiometry: 1.0
species: AA

re27
type: Reaction
kinetic law: CDMT00089
product: CDMT00088
reactant: CDMT00087
is version of: GO:0043241
fast: false
reversible: true
name: PSmad2 dimmer dissociation

CDMT00088
type: SpeciesReference
stoichiometry: 2.0
species: PSmad2n

CDMT00087
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 PSmad2 n

koff ns
type: Parameter
constant: false
units: per min
value: 2.03306

re29
type: Reaction
kinetic law: CDMT00092
product: CDMT00091
reactant: CDMT00090
is version of: GO:0005102
fast: false
reversible: true
name: non-specific binding of TGF-beta

CDMT00091
type: SpeciesReference
stoichiometry: 1.0
species: TGF beta ns

CDMT00090
type: SpeciesReference
stoichiometry: 1.0
species: TGF beta ex

min
type: SBMLUnitsDef
unit: CDMT00138
name: minute

CDMT00138
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

re26
type: Reaction
kinetic law: CDMT00086
product: CDMT00085
reactant: CDMT00084
is version of: GO:0051169
fast: false
reversible: false
name: PSmad2 dimer nuclear import

CDMT00085
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 PSmad2 n

CDMT00084
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2 PSmad2 c

re13
type: Reaction
kinetic law: CDMT00041
product: CDMT00040
reactant: CDMT00039
is version of: GO:0030163
fast: false
reversible: false
name: TGF-beta constitutive degradation

CDMT00040
type: SpeciesReference
stoichiometry: 1.0
species: empty degraded

CDMT00039
type: SpeciesReference
stoichiometry: 1.0
species: TGF beta endo

TGF beta endo
type: Species
boundary condition: false
in compartment: Vcyt
has only substance units: false
initial amount: NaN
is version of: P01137
occurs in: GO:0005769
substance units: nM
name: TGF_beta_endo
constant: false
initial concentration: 0.0
is: SBO:0000252

re14
type: Reaction
kinetic law: CDMT00047
product: CDMT00046
reactant: CDMT00045
is version of: GO:0051169
fast: false
reversible: false
name: Smad2 nuclear import

CDMT00046
type: SpeciesReference
stoichiometry: 1.0
species: Smad2n

CDMT00045
type: SpeciesReference
stoichiometry: 1.0
species: Smad2c

kimp Smad2
type: Parameter
constant: true
units: per min
value: 0.156

kon ns
type: Parameter
constant: true
units: per min
value: 0.0505413

re5
type: Reaction
kinetic law: CDMT00016
product: CDMT00015
reactant: CDMT00014
is version of: GO:0032800
fast: false
reversible: false
name: T2R production

CDMT00015
type: SpeciesReference
stoichiometry: 1.0
species: T2R surf

CDMT00014
type: SpeciesReference
stoichiometry: 1.0
species: AA

re4
type: Reaction
kinetic law: CDMT00013
product: CDMT00012
reactant: CDMT00011
is version of: GO:0032801
fast: false
reversible: false
name: T1R constitutive degradation

CDMT00012
type: SpeciesReference
stoichiometry: 1.0
species: empty degraded

CDMT00011
type: SpeciesReference
stoichiometry: 1.0
species: T1R endo

ki
type: Parameter
constant: true
units: per min
value: 0.333

TGF beta dose
type: Parameter
constant: false
units: mol per cell
value: 0.0

totalNumT2R
type: Parameter
constant: false
units: mol per cell
value: 2272.0

single pulse duration
type: Parameter
constant: true
units: min
value: 0.5

medium TGF beta amount
type: Parameter
constant: false
units: mol per cell
value: 0.0

klid
type: Parameter
constant: true
units: per min
value: 0.0233678

ka LRC
type: Parameter
constant: true
units: third order
value: 117.897

re24
type: Reaction
kinetic law: CDMT00080
product: CDMT00079
reactant: CDMT00078
is version of: GO:0006470
fast: false
reversible: false
name: Smad2 dephosphorylation

CDMT00079
type: SpeciesReference
stoichiometry: 1.0
species: Smad2n

CDMT00078
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2n

re11
type: Reaction
kinetic law: CDMT00044
product: CDMT00043
reactant: CDMT00042
is version of: GO:0032801
fast: false
reversible: false
name: LRC constitutive degradation

CDMT00043
type: SpeciesReference
stoichiometry: 1.0
species: empty degraded

CDMT00042
type: SpeciesReference
stoichiometry: 1.0
species: LRC endo

re20
type: Reaction
kinetic law: CDMT00066
product: CDMT00065
reactant: CDMT00064
is version of: GO:0051169
fast: false
reversible: false
name: PSmad2 nuclear export

CDMT00065
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2c

CDMT00064
type: SpeciesReference
stoichiometry: 1.0
species: PSmad2n

re12
type: Reaction
product: CDMT00037
name: dissociation of LRC in endosome
product: CDMT00035
reversible: false
is version of: GO:0043241
product: CDMT00036
kinetic law: CDMT00038
reactant: CDMT00034
fast: false

CDMT00037
type: SpeciesReference
stoichiometry: 1.0
species: TGF beta endo

CDMT00035
type: SpeciesReference
stoichiometry: 1.0
species: T1R endo

CDMT00036
type: SpeciesReference
stoichiometry: 1.0
species: T2R endo

CDMT00034
type: SpeciesReference
stoichiometry: 1.0
species: LRC endo

re3
type: Reaction
kinetic law: CDMT00010
product: CDMT00009
reactant: CDMT00008
is version of: GO:0032456
fast: false
reversible: false
name: T1R recycling from early endosome

CDMT00009
type: SpeciesReference
stoichiometry: 1.0
species: T1R surf

CDMT00008
type: SpeciesReference
stoichiometry: 1.0
species: T1R endo

totalNuclearPSmad2
type: Parameter
constant: false
units: nM
value: 0.0

ORG:
  orgname: BIOSS Centre for Biological Signalling Studies, University of Freiburg
n:
  given: Zhike
  family: Zi

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

W3 CDTF: Thu Jul 14 13:23:21 BST 2011

W3 CDTF: Fri Jun 07 16:42:26 BST 2013