BIOMD0000000340
type: SBMLModel
reaction: 112
parameter: 201
species: 54
parameter: 179
reaction: 75
reaction: 72
species: 26
parameter: 216
name: Irreversible association
parameter: 197
parameter: 213
reaction: 121
species: 1
species: 42
reaction: 128
reaction: 55
function def: 230
reaction: 107
reaction: 170
species: 12
reaction: 84
reaction: 89
parameter: 208
parameter: 220
reaction: 108
parameter: 189
species: 30
reaction: 138
reaction: 150
parameter: 209
reaction: 167
parameter: 191
reaction: 130
reaction: 168
name: Warfarin inhibited first order kinetics
reaction: 147
parameter: 223
parameter: 205
is described by: http://identifiers.org/pubmed/19516255
reaction: 65
parameter: 183
function def: 231
reaction: 114
reaction: 164
parameter: 203
reaction: 91
reaction: 143
parameter: 184
reaction: 98
parameter: 217
reaction: 77
rule: 240
species: 47
reaction: 144
species: 28
notes: This model is from the article: A comprehensive model for the humoral coagulation network in humans. Wajima T, Isbister GK, Duffull SB. Clinical Pharmacology and therapeutics Volume 86, Issue 3, 10 June 2009, EPub 19516255 , Abstract: Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration-time and time-effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.
reaction: 71
reaction: 123
reaction: 78
parameter: 199
parameter: 215
parameter: 196
units def: 186716
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reaction: 57
parameter: 180
species: 14
name: Factor production
species: 35
reaction: 156
species: 51
species: 32
parameter: 211
reaction: 74
parameter: 192
parameter: 228
species: 23
reaction: 120

112
type: Reaction
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reversible: false
name: dII

189354
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17
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name: II

229
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spatial dimensions: 3.0
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201
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name: d_XI

54
type: Species
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initial concentration: 115.4754
initial amount: NaN
in compartment: 229
name: VK_p

179
type: Parameter
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value: 0.1
name: VKH2(0)

75
type: Reaction
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product: 187700
reactant: 187688
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reversible: false
name: r21

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187688
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24
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72
type: Reaction
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057872
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057870
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47
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22
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216
type: Parameter
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197
type: Parameter
constant: true
value: 0.2
name: warfarin_CL

213
type: Parameter
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value: 8945.5
name: Fg(0)

121
type: Reaction
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reversible: false
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189584
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12
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42
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name: VK

128
type: Reaction
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reactant: 189753
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reversible: false
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057991
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value: 0.69
name: k1

189753
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50
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55
type: Reaction
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057830
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value: 1.0E-6
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057829
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name: v

186752
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species: 3

3
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186740
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2
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107
type: Reaction
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product: 189174
fast: false
reversible: false
name: pPC_VKH2

35
type: Species
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189174
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27
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170
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40
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84
type: Reaction
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reactant: 188111
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reversible: false
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057895
type: LocalParameter
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value: 0.1
name: c

188135
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species: 31

31
type: Species
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constant: false
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188123
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29
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188111
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10
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name: VII

89
type: Reaction
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057904
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057903
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30
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188367
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species: 6

6
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188355
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5
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208
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constant: true
value: 0.05
name: d_Pk

220
type: Parameter
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value: 1.0
name: R2

108
type: Reaction
kinetic law: 189234
modifier: 189222
product: 189210
fast: false
reversible: false
name: pPS_VKH2

189210
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species: 34

34
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initial amount: NaN
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name: PS

189
type: Parameter
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value: 0.228
name: d_VKO

138
type: Reaction
kinetic law: 190005
reactant: 189993
fast: false
reversible: false
name: dTFPI

189993
type: SpeciesReference
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stoichiometry: 1.0
species: 33

33
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initial amount: NaN
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name: TFPI

150
type: Reaction
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reactant: 190282
fast: false
reversible: false
name: dXIa

058017
type: LocalParameter
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value: 20.0
name: k1

190282
type: SpeciesReference
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species: 7

7
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name: XIa

209
type: Parameter
constant: true
value: 375.0
name: XII(0)

167
type: Reaction
kinetic law: 190726
product: 190714
fast: false
reversible: false
name: pPk

190714
type: SpeciesReference
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stoichiometry: 1.0
species: 45

45
type: Species
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initial concentration: 450.0
initial amount: NaN
in compartment: 229
name: Pk

191
type: Parameter
constant: true
value: 0.1
name: VKO(0)

130
type: Reaction
kinetic law: 189813
reactant: 189801
fast: false
reversible: false
name: dK

057993
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

189801
type: SpeciesReference
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stoichiometry: 1.0
species: 39

39
type: Species
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constant: false
boundary condition: false
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initial concentration: 0.0
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in compartment: 229
name: K

168
type: Reaction
kinetic law: 190751
product: 190739
fast: false
reversible: false
name: pVK

190739
type: SpeciesReference
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stoichiometry: 1.0
species: 42

147
type: Reaction
kinetic law: 190222
reactant: 190210
fast: false
reversible: false
name: dVIIa_TF_Xa_TFPI

058013
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

190210
type: SpeciesReference
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stoichiometry: 1.0
species: 49

49
type: Species
has only substance units: false
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initial concentration: 0.0
initial amount: NaN
has part: P13726
boundary condition: false
has part: P08709
has part: P10646
name: VIIa_TF_Xa_TFPI
in compartment: 229
constant: false

223
type: Parameter
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constant: true
value: 0.85
name: c46

205
type: Parameter
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constant: true
value: 0.05
name: d_Pg

65
type: Reaction
kinetic law: 187239
modifier: 187227
reactant: 187215
fast: false
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name: r11

057854
type: LocalParameter
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value: 1.0
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057853
type: LocalParameter
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4
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constant: false
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187215
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16
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is version of: P12259
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183
type: Parameter
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value: 0.018
name: d_X

114
type: Reaction
kinetic law: 189426
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fast: false
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name: dTF

057977
type: LocalParameter
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value: 0.05
name: k1

189414
type: SpeciesReference
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stoichiometry: 1.0
species: 29

164
type: Reaction
kinetic law: 190654
product: 190642
fast: false
reversible: false
name: pPg

190642
type: SpeciesReference
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stoichiometry: 1.0
species: 24

203
type: Parameter
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constant: true
value: 0.032
name: d_Fg

91
type: Reaction
kinetic law: 188487
product: 188475
reactant: 188463
reactant: 188451
fast: false
reversible: false
name: r37

057908
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

188475
type: SpeciesReference
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188463
type: SpeciesReference
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188451
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25
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143
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058008
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name: k1

190114
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14
type: Species
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184
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98
type: Reaction
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188811
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51
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name: IIa_ATIII_Heparin
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188799
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188787
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217
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77
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187784
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144
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190137
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28
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71
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057868
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057867
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187507
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46
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18
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123
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189633
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057886
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057885
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187844
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species: 25

187832
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199
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constant: true
value: 0.012
name: d_XII

215
type: Parameter
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value: 2154.3
name: Pg(0)

196
type: Parameter
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name: warfarin_Vd

186716
type: SBMLUnitsDef
unit: 186728
name: substance

186728
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exponent: 1.0
scale: -9
multipler: 1.0
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186826
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180
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156
type: Reaction
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name: eHeparinIIa

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32
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211
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name: XI(0)

74
type: Reaction
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reversible: false
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057876
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187652
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187640
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23
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initial concentration: 70.3

192
type: Parameter
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constant: true
value: 5.08333333333333E-4
name: vitaminK_k21/Vc

228
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value: 24.0
name: heparin_infusion_duration [hr]

120
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reactant: 189560
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reversible: false
name: dVIIIa

057983
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value: 20.0
name: k1

189560
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175
type: Parameter
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name: IX(0)

172
type: Parameter
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name: IC50

20
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name: DP

106
type: Reaction
kinetic law: 189162
modifier: 189150
product: 189138
fast: false
reversible: false
name: pX_VKH2

189138
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 12

83
type: Reaction
kinetic law: 188099
product: 188087
reactant: 188075
reactant: 188062
fast: false
reversible: false
name: r29

057893
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

188087
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 30

188075
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 29

188062
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 11

11
type: Species
is version of: P08709
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: VIIa

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

207
type: Parameter
is: SBO:0000035
constant: true
value: 20.0
name: d_TFPI

132
type: Reaction
kinetic law: 189861
reactant: 189849
fast: false
reversible: false
name: dP

057995
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

189849
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 21

188
type: Parameter
is: SBO:0000035
constant: true
value: 0.228
name: d_VKH2

137
type: Reaction
kinetic law: 189981
reactant: 189969
fast: false
reversible: false
name: dD

058001
type: LocalParameter
is: SBO:0000035
value: 0.1
name: k1

189969
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 47

166
type: Reaction
kinetic law: 190702
product: 190690
fast: false
reversible: false
name: pTFPI

190690
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 33

219
type: Parameter
constant: true
value: 0.140845070422535
name: R1

149
type: Reaction
kinetic law: 190270
reactant: 190258
fast: false
reversible: false
name: dCA

058016
type: LocalParameter
is: SBO:0000035
value: 0.05
name: k1

190258
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 37

37
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: CA

146
type: Reaction
kinetic law: 190198
reactant: 190186
fast: false
reversible: false
name: dXa_TFPI

058012
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

190186
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 32

182
type: Parameter
is: SBO:0000035
constant: true
value: 0.029
name: d_IX

113
type: Reaction
kinetic law: 189402
product: 189390
reactant: 189378
fast: false
reversible: false
name: dIIa

057976
type: LocalParameter
is: SBO:0000035
value: 67.4
name: k1

189390
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 48

48
type: Species
name: TAT
initial amount: NaN
in compartment: 229
initial concentration: 0.0
boundary condition: false
has only substance units: false
has part: P00734
has part: P01008
constant: false

189378
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 1

158
type: Reaction
kinetic law: 190510
product: 190498
fast: false
reversible: false
name: pXII

190498
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 38

38
type: Species
is: P00748
constant: false
boundary condition: false
has only substance units: false
initial concentration: 375.0
initial amount: NaN
in compartment: 229
name: XII

90
type: Reaction
kinetic law: 188439
modifier: 188427
product: 188415
reactant: 188403
fast: false
reversible: false
name: r36

057906
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057905
type: LocalParameter
is: SBO:0000025
value: 1000.0
name: v

188415
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 30

188403
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 31

59
type: Reaction
kinetic law: 186959
modifier: 186947
product: 186935
reactant: 186923
fast: false
reversible: false
name: r5

057840
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057838
type: LocalParameter
is: SBO:0000025
value: 10.0
name: v

186935
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 7

186923
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 8

8
type: Species
is: P03951
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.6
initial amount: NaN
in compartment: 229
name: XI

142
type: Reaction
kinetic law: 190102
reactant: 190089
fast: false
reversible: false
name: dVa_Xa

058007
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

190089
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 36

36
type: Species
has part: P00742
has part: P12259
constant: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
has only substance units: false
name: Va_Xa
boundary condition: false

53
type: Species
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: A_warf

76
type: Reaction
kinetic law: 187772
modifier: 187760
product: 187748
reactant: 187736
fast: false
reversible: false
name: r22

057880
type: LocalParameter
is: SBO:0000371
value: 10000.0
name: k

057879
type: LocalParameter
is: SBO:0000025
value: 5.0
name: v

187748
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 21

187736
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 24

194
type: Parameter
is: SBO:0000035
constant: true
value: 0.693
name: heparin_ke

176
type: Parameter
constant: true
value: 174.3
name: X(0)

70
type: Reaction
kinetic law: 187483
modifier: 187471
product: 187458
reactant: 187446
fast: false
reversible: false
name: r16

057866
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057865
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

187458
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 22

187446
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 18

125
type: Reaction
kinetic law: 189693
reactant: 189681
fast: false
reversible: false
name: dXII

189681
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 38

214
type: Parameter
constant: true
value: 70.3
name: XIII(0)

122
type: Reaction
kinetic law: 189621
reactant: 189609
fast: false
reversible: false
name: dXa

057985
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

189609
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 13

13
type: Species
is version of: P00742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: Xa

154
type: Reaction
kinetic law: 190414
reactant: 190402
fast: false
reversible: false
name: eHeparinXa

190402
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 41

41
type: Species
constant: false
boundary condition: false
has only substance units: false
in compartment: 229
name: Xa_ATIII_Heparin
initial concentration: 0.0
initial amount: NaN
has part: CHEBI:28304
has part: P01008
has part: P00742

56
type: Reaction
kinetic law: 186814
modifier: 186802
reactant: 186790
fast: false
reversible: false
name: r2

057832
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057831
type: LocalParameter
is: SBO:0000025
value: 50.0
name: v

186790
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 3

174
type: Parameter
constant: true
value: 10.0
name: VII(0)

85
type: Reaction
kinetic law: 188197
product: 188185
reactant: 188173
reactant: 188161
fast: false
reversible: false
name: r31

057896
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

188185
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 49

188173
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 32

188161
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 30

105
type: Reaction
kinetic law: 189126
modifier: 189114
product: 189102
fast: false
reversible: false
name: pIX_VKH2

189102
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 5

82
type: Reaction
kinetic law: 188049
product: 188037
reactant: 188025
reactant: 188012
fast: false
reversible: false
name: r28

057892
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

188037
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 26

188025
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 28

188012
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 1

134
type: Reaction
kinetic law: 189909
reactant: 189897
fast: false
reversible: false
name: dAPC

057997
type: LocalParameter
is: SBO:0000035
value: 20.4
name: k1

189897
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 25

86
type: Reaction
kinetic law: 188245
product: 188233
reactant: 188221
reactant: 188209
fast: false
reversible: false
name: r32

057898
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

188233
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 32

188221
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 33

188209
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 13

210
type: Parameter
constant: true
value: 0.7
name: VIII(0)

186692
type: SBMLUnitsDef
unit: 186704
name: time

186704
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

151
type: Reaction
kinetic law: 190330
product: 190318
reactant: 190306
fast: false
reversible: false
name: dVKH2

190318
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 44

190306
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 35

9
type: Species
is version of: P00748
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: XIIa

227
type: Parameter
constant: true
value: 0.0
name: heparin_bolus

69
type: Reaction
kinetic law: 187433
modifier: 187421
product: 187409
reactant: 187397
fast: false
reversible: false
name: r15

057864
type: LocalParameter
is: SBO:0000371
value: 500.0
name: k

057863
type: LocalParameter
is: SBO:0000025
value: 500.0
name: v

187409
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 46

187397
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 19

19
type: Species
initial amount: NaN
constant: false
name: Fg
has part: P02679
has only substance units: false
initial concentration: 8945.5
boundary condition: false
in compartment: 229
has part: P02675
has part: P02671

101
type: Reaction
kinetic law: 188969
modifier: 188956
product: 188944
reactant: 188932
fast: false
reversible: false
name: r47

43
type: Species
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: C_warf

188944
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 35

188932
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 42

187
type: Parameter
constant: true
value: 0.0228
name: d_VK2

66
type: Reaction
kinetic law: 187287
modifier: 187275
product: 187263
reactant: 187251
fast: false
reversible: false
name: r12

057856
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057855
type: LocalParameter
is: SBO:0000025
value: 100.0
name: v

187263
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 1

187251
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 17

118
type: Reaction
kinetic law: 189524
reactant: 189511
fast: false
reversible: false
name: dVIIa

057981
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

189511
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 11

95
type: Reaction
kinetic law: 188679
modifier: 188667
product: 188655
reactant: 188643
fast: false
reversible: false
name: r41

057916
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057915
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

188655
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 9

188643
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 38

61
type: Reaction
kinetic law: 187056
modifier: 187043
product: 187031
reactant: 187019
fast: false
reversible: false
name: r7

057844
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057843
type: LocalParameter
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value: 0.02
name: v

187031
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 13

187019
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 12

161
type: Reaction
kinetic law: 190582
product: 190570
fast: false
reversible: false
name: pV

190570
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 15

15
type: Species
is: P12259
constant: false
boundary condition: false
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initial concentration: 26.7
initial amount: NaN
in compartment: 229
name: V

110
type: Reaction
kinetic law: 189306
product: 189294
reactant: 189282
fast: false
reversible: false
name: dF

057972
type: LocalParameter
is: SBO:0000035
value: 0.05
name: k1

189294
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 46

189282
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 18

62
type: Reaction
kinetic law: 187105
modifier: 187093
product: 187081
reactant: 187068
fast: false
reversible: false
name: r8

057846
type: LocalParameter
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value: 0.1
name: k

057845
type: LocalParameter
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value: 2.0
name: v

187081
type: SpeciesReference
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stoichiometry: 1.0
species: 13

187068
type: SpeciesReference
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stoichiometry: 1.0
species: 12

115
type: Reaction
kinetic law: 189451
reactant: 189438
fast: false
reversible: false
name: dV

189438
type: SpeciesReference
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stoichiometry: 1.0
species: 15

92
type: Reaction
kinetic law: 188535
modifier: 188523
product: 188511
reactant: 188499
fast: false
reversible: false
name: r38

057910
type: LocalParameter
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value: 10.0
name: k

057909
type: LocalParameter
is: SBO:0000025
value: 1.0
name: v

188511
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 11

188499
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

218
type: Parameter
constant: true
value: 450.0
name: Pk(0)

141
type: Reaction
kinetic law: 190077
reactant: 190065
fast: false
reversible: false
name: dAPC_PS

058005
type: LocalParameter
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value: 20.0
name: k1

190065
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 4

198
type: Parameter
constant: true
value: 0.02
name: warfarin_ke

221
type: Parameter
is: SBO:0000036
constant: true
value: 0.119718309859155
name: c44

148
type: Reaction
kinetic law: 190246
reactant: 190234
fast: false
reversible: false
name: dTAT

058014
type: LocalParameter
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value: 0.2
name: k1

190234
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 48

178
type: Parameter
constant: true
value: 300.0
name: PS(0)

127
type: Reaction
kinetic law: 189741
reactant: 189729
fast: false
reversible: false
name: dXIII

189729
type: SpeciesReference
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stoichiometry: 1.0
species: 23

157
type: Reaction
kinetic law: 190486
reactant: 190474
fast: false
reversible: false
name: dXI

058022
type: LocalParameter
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value: 0.1
name: k1

190474
type: SpeciesReference
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stoichiometry: 1.0
species: 8

58
type: Reaction
kinetic law: 186911
modifier: 186899
product: 186886
reactant: 186874
fast: false
reversible: false
name: r4

057836
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057835
type: LocalParameter
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value: 7.0
name: v

186886
type: SpeciesReference
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stoichiometry: 1.0
species: 7

186874
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 8

88
type: Reaction
kinetic law: 188343
modifier: 188330
product: 188318
reactant: 188306
fast: false
reversible: false
name: r34

057902
type: LocalParameter
is: SBO:0000371
value: 200.0
name: k

057901
type: LocalParameter
is: SBO:0000025
value: 900.0
name: v

188318
type: SpeciesReference
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stoichiometry: 1.0
species: 13

188306
type: SpeciesReference
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stoichiometry: 1.0
species: 12

212
type: Parameter
constant: true
value: 26.7
name: V(0)

193
type: Parameter
is: SBO:0000035
constant: true
value: 0.0587
name: vitaminK_k12

124
type: Reaction
kinetic law: 189669
reactant: 189657
fast: false
reversible: false
name: dIXa

057987
type: LocalParameter
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value: 20.0
name: k1

189657
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 6

226
type: Parameter
is: SBO:0000048
constant: false
value: 0.0
name: heparin_infusion

103
type: Reaction
kinetic law: 189054
modifier: 189041
product: 189029
fast: false
reversible: false
name: pII_VKH2

189029
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 17

153
type: Reaction
kinetic law: 190390
reactant: 190378
fast: false
reversible: false
name: eHeparin

190378
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 40

68
type: Reaction
kinetic law: 187385
modifier: 187373
product: 187361
reactant: 187348
fast: false
reversible: false
name: r14

057862
type: LocalParameter
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value: 0.5
name: k

057861
type: LocalParameter
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value: 20000.0
name: v

187361
type: SpeciesReference
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stoichiometry: 1.0
species: 18

187348
type: SpeciesReference
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stoichiometry: 1.0
species: 19

80
type: Reaction
kinetic law: 187952
product: 187940
reactant: 187928
reactant: 187916
fast: false
reversible: false
name: r26

057889
type: LocalParameter
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value: 0.01
name: c

187940
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 14

187928
type: SpeciesReference
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stoichiometry: 1.0
species: 3

187916
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 6

173
type: Parameter
constant: true
value: 1394.4
name: II(0)

190
type: Parameter
constant: true
value: 1.0
name: VK(0)

97
type: Reaction
kinetic law: 188775
modifier: 188763
product: 188751
reactant: 188739
fast: false
reversible: false
name: r43

057922
type: LocalParameter
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value: 1.0
name: k

057921
type: LocalParameter
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value: 7.0
name: v

188751
type: SpeciesReference
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stoichiometry: 1.0
species: 39

188739
type: SpeciesReference
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stoichiometry: 1.0
species: 45

104
type: Reaction
kinetic law: 189090
modifier: 189078
product: 189066
fast: false
reversible: false
name: pVII_VKH2

189066
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 10

81
type: Reaction
kinetic law: 188000
product: 187988
reactant: 187976
reactant: 187964
fast: false
reversible: false
name: r27

057891
type: LocalParameter
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value: 0.5
name: c

187988
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 36

187976
type: SpeciesReference
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stoichiometry: 1.0
species: 13

187964
type: SpeciesReference
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stoichiometry: 1.0
species: 16

133
type: Reaction
kinetic law: 189885
reactant: 189873
fast: false
reversible: false
name: dPC

189873
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 27

60
type: Reaction
kinetic law: 187007
modifier: 186995
product: 186983
reactant: 186971
fast: false
reversible: false
name: r6

057842
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057841
type: LocalParameter
is: SBO:0000025
value: 0.1
name: v

186983
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 11

186971
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

222
type: Parameter
is: SBO:0000036
constant: true
value: 0.85
name: c45

163
type: Reaction
kinetic law: 190630
product: 190618
fast: false
reversible: false
name: pXIII

190618
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 23

236
type: Event
event assignment: 190826
trigger: 190813
use values from trigger time: true
name: warfarin_administration

190813
type: Trigger
persistant: true
initial value: true

64
type: Reaction
kinetic law: 187203
modifier: 187191
product: 187179
reactant: 187166
fast: false
reversible: false
name: r10

057852
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057850
type: LocalParameter
is: SBO:0000025
value: 50000.0
name: v

187179
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 16

187166
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 15

100
type: Reaction
kinetic law: 188920
product: 188907
reactant: 188895
reactant: 188883
fast: false
reversible: false
name: r46

188907
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 52

52
type: Species
boundary condition: false
initial amount: NaN
name: IXa_ATIII_Heparin
has part: P00740
initial concentration: 0.0
constant: false
has part: CHEBI:28304
in compartment: 229
has part: P01008
has only substance units: false

188895
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 40

188883
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 6

186
type: Parameter
constant: true
value: 24.0
name: vitaminK_Vc

202
type: Parameter
is: SBO:0000035
constant: true
value: 0.043
name: d_V

117
type: Reaction
kinetic law: 189499
reactant: 189487
fast: false
reversible: false
name: dVII

189487
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

94
type: Reaction
kinetic law: 188631
modifier: 188619
product: 188607
reactant: 188595
fast: false
reversible: false
name: r40

057914
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057913
type: LocalParameter
is: SBO:0000025
value: 0.2
name: v

188607
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 11

188595
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

73
type: Reaction
kinetic law: 187628
modifier: 187616
product: 187603
reactant: 187591
fast: false
reversible: false
name: r19

057874
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057873
type: LocalParameter
is: SBO:0000025
value: 1.0
name: v

187603
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 47

187591
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 22

160
type: Reaction
kinetic law: 190558
product: 190546
fast: false
reversible: false
name: pXI

190546
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 8

129
type: Reaction
kinetic law: 189789
reactant: 189777
fast: false
reversible: false
name: dPk

189777
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 45

159
type: Reaction
kinetic law: 190534
product: 190522
fast: false
reversible: false
name: pVIII

190522
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 2

140
type: Reaction
kinetic law: 190053
reactant: 190041
fast: false
reversible: false
name: dVII_TF

058004
type: LocalParameter
is: SBO:0000035
value: 0.7
name: k1

190041
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 31

109
type: Reaction
kinetic law: 189270
product: 189258
reactant: 189246
fast: false
reversible: false
name: dFg

189258
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 46

189246
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 19

195
type: Parameter
constant: true
value: 1.0
name: warfarin_ka

177
type: Parameter
constant: true
value: 60.0
name: PC(0)

237
type: Event
event assignment: 190851
trigger: 190838
use values from trigger time: true
name: heparin_administration

190838
type: Trigger
persistant: true
initial value: true

126
type: Reaction
kinetic law: 189717
reactant: 189705
fast: false
reversible: false
name: dXIIa

057989
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

189705
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 9

155
type: Reaction
kinetic law: 190438
reactant: 190426
fast: false
reversible: false
name: eHeparinIXa

190426
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 52

152
type: Reaction
kinetic law: 190366
product: 190354
reactant: 190342
fast: false
reversible: true
name: VK_transport

190354
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 54

190342
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 42

169
type: Reaction
kinetic law: 190775
reactant: 190763
fast: false
reversible: false
name: dVK

190763
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 42

W3 CDTF: Fri Apr 20 22:45:50 BST 2012

135
type: Reaction
kinetic law: 189933
reactant: 189921
fast: false
reversible: false
name: dPS

189921
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 34

87
type: Reaction
kinetic law: 188294
modifier: 188281
product: 188269
reactant: 188257
fast: false
reversible: false
name: r33

057900
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057899
type: LocalParameter
is: SBO:0000025
value: 70.0
name: v

188269
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 30

188257
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 31

224
type: Parameter
is: SBO:0000035
constant: true
value: 0.2052
name: d_VK

206
type: Parameter
is: SBO:0000035
constant: true
value: 0.05
name: d_Tmod

139
type: Reaction
kinetic law: 190029
reactant: 190017
fast: false
reversible: false
name: dVIIa_TF

058003
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

190017
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 30

136
type: Reaction
kinetic law: 189957
reactant: 189945
fast: false
reversible: false
name: dFDP

057999
type: LocalParameter
is: SBO:0000035
value: 3.5
name: k1

189945
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 46

171
type: Parameter
constant: true
value: 1.0
name: I_max

225
type: Parameter
constant: true
value: 4.0
name: warfarin_daily_dose

165
type: Reaction
kinetic law: 190678
product: 190666
fast: false
reversible: false
name: pTmod

190666
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 28

102
type: Reaction
kinetic law: 189017
modifier: 189005
product: 188993
reactant: 188981
fast: false
reversible: false
name: r48

188993
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 42

188981
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 44

204
type: Parameter
is: SBO:0000035
constant: true
value: 0.0036
name: d_XIII

67
type: Reaction
kinetic law: 187336
modifier: 187324
product: 187312
reactant: 187299
fast: false
reversible: false
name: r13

057860
type: LocalParameter
is: SBO:0000371
value: 500.0
name: k

057858
type: LocalParameter
is: SBO:0000025
value: 9.0
name: v

187312
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 1

187299
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 17

W3 CDTF: Tue Jul 05 18:07:40 BST 2011

185
type: Parameter
is: SBO:0000035
constant: true
value: 0.0165
name: d_PS

119
type: Reaction
kinetic law: 189548
reactant: 189536
fast: false
reversible: false
name: dVIII

189536
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 2

99
type: Reaction
kinetic law: 188871
product: 188859
reactant: 188847
reactant: 188835
fast: false
reversible: false
name: r45

188859
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 41

188847
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 40

188835
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 13

131
type: Reaction
kinetic law: 189837
reactant: 189825
fast: false
reversible: false
name: dPg

189825
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 24

96
type: Reaction
kinetic law: 188727
modifier: 188715
product: 188703
reactant: 188691
fast: false
reversible: false
name: r42

057920
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057918
type: LocalParameter
is: SBO:0000025
value: 70.0
name: v

188703
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 9

188691
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 38

116
type: Reaction
kinetic law: 189475
reactant: 189463
fast: false
reversible: false
name: dVa

057979
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

189463
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 16

93
type: Reaction
kinetic law: 188583
modifier: 188571
product: 188559
reactant: 188547
fast: false
reversible: false
name: r39

057912
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057911
type: LocalParameter
is: SBO:0000025
value: 1.0
name: v

188559
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 11

188547
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

145
type: Reaction
kinetic law: 190174
reactant: 190161
fast: false
reversible: false
name: dIIa_Tmod

058010
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

190161
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 26

162
type: Reaction
kinetic law: 190606
product: 190594
fast: false
reversible: false
name: pFg

190594
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 19

79
type: Reaction
kinetic law: 187904
modifier: 187892
reactant: 187880
fast: false
reversible: false
name: r25

057888
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

057887
type: LocalParameter
is: SBO:0000025
value: 2.0
name: v

187880
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 36

111
type: Reaction
kinetic law: 189342
product: 189330
reactant: 189318
fast: false
reversible: false
name: dXF

057973
type: LocalParameter
is: SBO:0000035
value: 0.05
name: k1

189330
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 47

189318
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 22

200
type: Parameter
is: SBO:0000035
constant: true
value: 0.058
name: d_VIII

63
type: Reaction
kinetic law: 187154
modifier: 187142
product: 187130
reactant: 187117
fast: false
reversible: false
name: r9

057848
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

057847
type: LocalParameter
is: SBO:0000025
value: 1.0E-9
name: v

187130
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 13

187117
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 12

181
type: Parameter
is: SBO:0000035
constant: true
value: 0.12
name: d_VII