BIOMD0000000339
type: SBMLModel
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parameter: 196
parameter: 202
reaction: 149
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function def: 229
notes: This model is from the article: A comprehensive model for the humoral coagulation network in humans. Wajima T, Isbister GK, Duffull SB. Clinical Pharmacology and therapeutics Volume 86, Issue 3, 10 June 2009, EPub 19516255 , Abstract: Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration-time and time-effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.
reaction: 100
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reaction: 150
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event: 232
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function def: 230
units def: 127997
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reaction: 135
reaction: 126
function def: 231
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reaction: 129
reaction: 64
parameter: 194
parameter: 200
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reaction: 82
curated: true
reaction: 57
reaction: 85
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reaction: 97
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name: Irreversible association
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66
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59
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53
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214
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150
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224
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28
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232
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208
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32
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114
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020414
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130688
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29
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34
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164
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167
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131991
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45
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50
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172
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71
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182
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109
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135
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126
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130628
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 17

153
type: Reaction
kinetic law: 131666
reactant: 131653
fast: false
reversible: false
name: eHeparin

131653
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 40

103
type: Reaction
kinetic law: 130326
modifier: 130313
product: 130301
fast: false
reversible: false
name: pII_VKH2

35
type: Species
is version of: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 226
name: VKH2

130301
type: SpeciesReference
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stoichiometry: 1.0
species: 17

48
type: Species
has part: P00734
in compartment: 226
initial amount: NaN
boundary condition: false
name: TAT
initial concentration: 0.0
has only substance units: false
constant: false
has part: P01008

217
type: Parameter
constant: true
value: 2.5
name: TFPI(0)

218
type: Parameter
constant: true
value: 450.0
name: Pk(0)

170
type: Parameter
constant: true
value: 1.0
name: I_max

156
type: Reaction
kinetic law: 131739
reactant: 131726
fast: false
reversible: false
name: eHeparinIIa

131726
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 51

51
type: Species
in compartment: 226
has part: P01008
boundary condition: false
initial concentration: 0.0
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has only substance units: false
constant: false
name: IIa_ATIII_Heparin
has part: P00734
initial amount: NaN

106
type: Reaction
kinetic law: 130435
modifier: 130422
product: 130410
fast: false
reversible: false
name: pX_VKH2

130410
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 12

180
type: Parameter
is: SBO:0000035
constant: true
value: 0.12
name: d_VII

133
type: Reaction
kinetic law: 131161
reactant: 131149
fast: false
reversible: false
name: dPC

131149
type: SpeciesReference
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stoichiometry: 1.0
species: 27

27
type: Species
is: P04070
constant: false
boundary condition: false
has only substance units: false
initial concentration: 60.0
initial amount: NaN
in compartment: 226
name: PC

121
type: Reaction
kinetic law: 130870
reactant: 130858
fast: false
reversible: false
name: dX

130858
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 12

124
type: Reaction
kinetic law: 130944
reactant: 130932
fast: false
reversible: false
name: dIXa

020425
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

130932
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 6

52
type: Species
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: A_warf

62
type: Reaction
kinetic law: 128384
modifier: 128372
product: 128359
reactant: 128347
fast: false
reversible: false
name: r8

020298
type: LocalParameter
is: SBO:0000371
value: 0.1
name: k

020296
type: LocalParameter
is: SBO:0000025
value: 2.0
name: v

128359
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 13

128347
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 12

192
type: Parameter
is: SBO:0000035
constant: true
value: 0.0587
name: VitaminK_k12

33
type: Species
is: P10646
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: 226
name: TFPI

145
type: Reaction
kinetic law: 131449
reactant: 131437
fast: false
reversible: false
name: dIIa_Tmod

020448
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

131437
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 26

175
type: Parameter
constant: true
value: 174.3
name: X(0)

83
type: Reaction
kinetic law: 129371
product: 129359
reactant: 129347
reactant: 129334
fast: false
reversible: false
name: r29

020362
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

129359
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 30

129347
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 29

129334
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 11

W3 CDTF: Tue Jul 05 18:07:03 BST 2011

178
type: Parameter
constant: true
value: 0.1
name: VKH2(0)

138
type: Reaction
kinetic law: 131281
reactant: 131269
fast: false
reversible: false
name: dTFPI

131269
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 33

74
type: Reaction
kinetic law: 128950
modifier: 128938
product: 128926
reactant: 128914
fast: false
reversible: false
name: r20

020340
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020338
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

128926
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 50

128914
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 23

23
type: Species
name: XIII
initial amount: NaN
has only substance units: false
in compartment: 226
has part: P05160
has part: P00488
initial concentration: 70.3
constant: false
boundary condition: false

185
type: Parameter
constant: true
value: 24.0
name: VitaminK_Vc

188
type: Parameter
constant: true
value: 0.228
name: d_VKO

210
type: Parameter
constant: true
value: 0.7
name: VIII(0)

91
type: Reaction
kinetic law: 129759
product: 129747
reactant: 129735
reactant: 129723
fast: false
reversible: false
name: r37

020375
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

129747
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 4

129735
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 34

129723
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 25

25
type: Species
is version of: P04070
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: APC

92
type: Reaction
kinetic law: 129807
modifier: 129795
product: 129783
reactant: 129771
fast: false
reversible: false
name: r38

020380
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

020377
type: LocalParameter
is: SBO:0000025
value: 1.0
name: v

129783
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 11

129771
type: SpeciesReference
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stoichiometry: 1.0
species: 10

95
type: Reaction
kinetic law: 129951
modifier: 129939
product: 129927
reactant: 129915
fast: false
reversible: false
name: r41

020392
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020390
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

129927
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 9

129915
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 38

159
type: Reaction
kinetic law: 131811
product: 131799
fast: false
reversible: false
name: pVIII

131799
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 2

2
type: Species
is: P00451
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 226
name: VIII

197
type: Parameter
constant: true
value: 0.02
name: Warfarin_ke

203
type: Parameter
is: SBO:0000035
constant: true
value: 0.032
name: d_Fg

130
type: Reaction
kinetic law: 131089
reactant: 131077
fast: false
reversible: false
name: dK

020431
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

131077
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 39

69
type: Reaction
kinetic law: 128710
modifier: 128698
product: 128686
reactant: 128674
fast: false
reversible: false
name: r15

020322
type: LocalParameter
is: SBO:0000371
value: 500.0
name: k

020320
type: LocalParameter
is: SBO:0000025
value: 500.0
name: v

128686
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 46

128674
type: SpeciesReference
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stoichiometry: 1.0
species: 19

88
type: Reaction
kinetic law: 129615
modifier: 129603
product: 129591
reactant: 129579
fast: false
reversible: false
name: r34

020370
type: LocalParameter
is: SBO:0000371
value: 200.0
name: k

020369
type: LocalParameter
is: SBO:0000025
value: 900.0
name: v

129591
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 13

129579
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 12

78
type: Reaction
kinetic law: 129142
modifier: 129130
product: 129118
reactant: 129106
fast: false
reversible: false
name: r24

020354
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020352
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

129118
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 25

129106
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 27

160
type: Reaction
kinetic law: 131835
product: 131823
fast: false
reversible: false
name: pXI

131823
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 8

101
type: Reaction
kinetic law: 130240
modifier: 130228
product: 130216
reactant: 130204
fast: false
reversible: false
name: r47

43
type: Species
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: C_warf

130216
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 35

130204
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 42

42
type: Species
is: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 226
name: VK

151
type: Reaction
kinetic law: 131605
product: 131593
reactant: 131581
fast: false
reversible: false
name: dVKH2

131593
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 44

131581
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 35

215
type: Parameter
constant: true
value: 2154.3
name: Pg(0)

3
type: Species
is version of: P00451
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: VIIIa

225
type: Parameter
is: SBO:0000035
constant: true
value: 0.2052
name: d_VK

122
type: Reaction
kinetic law: 130894
reactant: 130882
fast: false
reversible: false
name: dXa

020423
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

130882
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 13

209
type: Parameter
constant: true
value: 375.0
name: XII(0)

60
type: Reaction
kinetic law: 128286
modifier: 128274
product: 128262
reactant: 128250
fast: false
reversible: false
name: r6

020292
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

020290
type: LocalParameter
is: SBO:0000025
value: 0.1
name: v

128262
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 11

128250
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

115
type: Reaction
kinetic law: 130724
reactant: 130712
fast: false
reversible: false
name: dV

130712
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 15

165
type: Reaction
kinetic law: 131955
product: 131943
fast: false
reversible: false
name: pTmod

131943
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 28

168
type: Reaction
kinetic law: 132027
product: 132015
fast: false
reversible: false
name: pVK

132015
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 42

173
type: Parameter
constant: true
value: 10.0
name: VII(0)

118
type: Reaction
kinetic law: 130797
reactant: 130785
fast: false
reversible: false
name: dVIIa

020419
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

130785
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 11

119
type: Reaction
kinetic law: 130821
reactant: 130809
fast: false
reversible: false
name: dVIII

130809
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 2

136
type: Reaction
kinetic law: 131233
reactant: 131221
fast: false
reversible: false
name: dFDP

020437
type: LocalParameter
is: SBO:0000035
value: 3.5
name: k1

131221
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 46

72
type: Reaction
kinetic law: 128854
modifier: 128842
product: 128830
reactant: 128818
fast: false
reversible: false
name: r18

020332
type: LocalParameter
is: SBO:0000371
value: 100.0
name: k

020331
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

128830
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 47

128818
type: SpeciesReference
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stoichiometry: 1.0
species: 22

22
type: Species
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has only substance units: false
in compartment: 226
constant: false
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name: XF
boundary condition: false
has part: P02671
initial amount: NaN
has part: P02679

183
type: Parameter
is: SBO:0000035
constant: true
value: 0.05
name: d_PC

127973
type: SBMLUnitsDef
unit: 127985
name: time

127985
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

127
type: Reaction
kinetic law: 131017
reactant: 131005
fast: false
reversible: false
name: dXIII

131005
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 23

157
type: Reaction
kinetic law: 131763
reactant: 131751
fast: false
reversible: false
name: dXI

020460
type: LocalParameter
is: SBO:0000035
value: 0.1
name: k1

131751
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 8

65
type: Reaction
kinetic law: 128518
modifier: 128505
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fast: false
reversible: false
name: r11

020308
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020306
type: LocalParameter
is: SBO:0000025
value: 50.0
name: v

128493
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 16

195
type: Parameter
constant: true
value: 10.0
name: Warfarin_Vd

201
type: Parameter
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value: 0.1
name: d_XI

148
type: Reaction
kinetic law: 131521
reactant: 131509
fast: false
reversible: false
name: dTAT

020452
type: LocalParameter
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value: 0.2
name: k1

131509
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 48

67
type: Reaction
kinetic law: 128614
modifier: 128602
product: 128590
reactant: 128578
fast: false
reversible: false
name: r13

020314
type: LocalParameter
is: SBO:0000371
value: 500.0
name: k

020313
type: LocalParameter
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value: 9.0
name: v

128590
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 1

128578
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 17

58
type: Reaction
kinetic law: 128190
modifier: 128177
product: 128165
reactant: 128153
fast: false
reversible: false
name: r4

020286
type: LocalParameter
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value: 1.0
name: k

020284
type: LocalParameter
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value: 7.0
name: v

128165
type: SpeciesReference
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stoichiometry: 1.0
species: 7

128153
type: SpeciesReference
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species: 8

86
type: Reaction
kinetic law: 129518
product: 129506
reactant: 129494
reactant: 129482
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reversible: false
name: r32

020366
type: LocalParameter
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value: 0.5
name: c

129506
type: SpeciesReference
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species: 32

129494
type: SpeciesReference
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species: 33

129482
type: SpeciesReference
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species: 13

169
type: Reaction
kinetic law: 132051
reactant: 132039
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name: dVK

132039
type: SpeciesReference
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species: 42

77
type: Reaction
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modifier: 129082
product: 129070
reactant: 129058
fast: false
reversible: false
name: r23

020350
type: LocalParameter
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value: 1.0
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020348
type: LocalParameter
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value: 2.0
name: v

129070
type: SpeciesReference
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stoichiometry: 1.0
species: 21

129058
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species: 24

213
type: Parameter
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value: 8945.5
name: Fg(0)

220
type: Parameter
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value: 1.0
name: R2

79
type: Reaction
kinetic law: 129178
modifier: 129166
reactant: 129154
fast: false
reversible: false
name: r25

020356
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value: 1.0
name: k

020355
type: LocalParameter
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value: 2.0
name: v

129154
type: SpeciesReference
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species: 36

223
type: Parameter
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constant: true
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name: c46

98
type: Reaction
kinetic law: 130096
product: 130084
reactant: 130072
reactant: 130060
fast: false
reversible: false
name: r44

130084
type: SpeciesReference
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species: 51

130072
type: SpeciesReference
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species: 40

130060
type: SpeciesReference
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species: 1

142
type: Reaction
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reactant: 131365
fast: false
reversible: false
name: dVa_Xa

020444
type: LocalParameter
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value: 20.0
name: k1

131365
type: SpeciesReference
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stoichiometry: 1.0
species: 36

206
type: Parameter
is: SBO:0000035
constant: true
value: 0.05
name: d_Tmod

207
type: Parameter
is: SBO:0000035
constant: true
value: 20.0
name: d_TFPI

191
type: Parameter
is: SBO:0000038
constant: true
value: 5.08333333333333E-4
name: VitaminK_k21/Vc

221
type: Parameter
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constant: true
value: 0.119718309859155
name: c44

110
type: Reaction
kinetic law: 130580
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reactant: 130556
fast: false
reversible: false
name: dF

020410
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value: 0.05
name: k1

130568
type: SpeciesReference
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stoichiometry: 1.0
species: 46

130556
type: SpeciesReference
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species: 18

113
type: Reaction
kinetic law: 130676
product: 130664
reactant: 130652
fast: false
reversible: false
name: dIIa

020413
type: LocalParameter
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value: 67.4
name: k1

130664
type: SpeciesReference
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stoichiometry: 1.0
species: 48

130652
type: SpeciesReference
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species: 1

163
type: Reaction
kinetic law: 131907
product: 131895
fast: false
reversible: false
name: pXIII

131895
type: SpeciesReference
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stoichiometry: 1.0
species: 23

104
type: Reaction
kinetic law: 130362
modifier: 130350
product: 130338
fast: false
reversible: false
name: pVII_VKH2

130338
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stoichiometry: 1.0
species: 10

166
type: Reaction
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product: 131967
fast: false
reversible: false
name: pTFPI

131967
type: SpeciesReference
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stoichiometry: 1.0
species: 33

154
type: Reaction
kinetic law: 131690
reactant: 131678
fast: false
reversible: false
name: eHeparinXa

131678
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 41

219
type: Parameter
constant: true
value: 0.140845070422535
name: R1

171
type: Parameter
constant: true
value: 0.34
name: IC50

107
type: Reaction
kinetic law: 130472
modifier: 130459
product: 130447
fast: false
reversible: false
name: pPC_VKH2

130447
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 27

181
type: Parameter
is: SBO:0000035
constant: true
value: 0.029
name: d_IX

108
type: Reaction
kinetic law: 130508
modifier: 130496
product: 130484
fast: false
reversible: false
name: pPS_VKH2

130484
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 34

134
type: Reaction
kinetic law: 131185
reactant: 131173
fast: false
reversible: false
name: dAPC

020435
type: LocalParameter
is: SBO:0000035
value: 20.4
name: k1

131173
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 25

125
type: Reaction
kinetic law: 130968
reactant: 130956
fast: false
reversible: false
name: dXII

130956
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 38

63
type: Reaction
kinetic law: 128432
modifier: 128420
product: 128408
reactant: 128396
fast: false
reversible: false
name: r9

020300
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

020299
type: LocalParameter
is: SBO:0000025
value: 1.0E-9
name: v

128408
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 13

128396
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 12

193
type: Parameter
is: SBO:0000035
constant: true
value: 0.693
name: Heparin_ke

146
type: Reaction
kinetic law: 131473
reactant: 131461
fast: false
reversible: false
name: dXa_TFPI

020449
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

131461
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 32

80
type: Reaction
kinetic law: 129226
product: 129214
reactant: 129202
reactant: 129190
fast: false
reversible: false
name: r26

020358
type: LocalParameter
is: SBO:0000036
value: 0.01
name: c

129214
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 14

129202
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 3

129190
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 6

81
type: Reaction
kinetic law: 129274
product: 129262
reactant: 129250
reactant: 129238
fast: false
reversible: false
name: r27

020359
type: LocalParameter
is: SBO:0000036
value: 0.5
name: c

129262
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 36

129250
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 13

129238
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 16

56
type: Reaction
kinetic law: 128093
modifier: 128081
reactant: 128069
fast: false
reversible: false
name: r2

020280
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020278
type: LocalParameter
is: SBO:0000025
value: 50.0
name: v

128069
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 3

176
type: Parameter
constant: true
value: 60.0
name: PC(0)

84
type: Reaction
kinetic law: 129420
product: 129408
reactant: 129396
reactant: 129383
fast: false
reversible: false
name: r30

020363
type: LocalParameter
is: SBO:0000036
value: 0.1
name: c

129408
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 31

129396
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 29

129383
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

179
type: Parameter
is: SBO:0000035
constant: true
value: 0.01
name: d_II

20
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: DP

75
type: Reaction
kinetic law: 128998
modifier: 128986
product: 128974
reactant: 128962
fast: false
reversible: false
name: r21

020344
type: LocalParameter
is: SBO:0000371
value: 5000.0
name: k

020342
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

128974
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 21

128962
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 24

186
type: Parameter
constant: true
value: 0.0228
name: d_VK2

139
type: Reaction
kinetic law: 131305
reactant: 131293
fast: false
reversible: false
name: dVIIa_TF

020440
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

131293
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 30

189
type: Parameter
constant: true
value: 1.0
name: VK(0)

211
type: Parameter
constant: true
value: 30.6
name: XI(0)

93
type: Reaction
kinetic law: 129855
modifier: 129843
product: 129831
reactant: 129819
fast: false
reversible: false
name: r39

020384
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

020382
type: LocalParameter
is: SBO:0000025
value: 1.0
name: v

129831
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 11

129819
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 10

96
type: Reaction
kinetic law: 130000
modifier: 129988
product: 129975
reactant: 129963
fast: false
reversible: false
name: r42

020396
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020394
type: LocalParameter
is: SBO:0000025
value: 70.0
name: v

129975
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 9

129963
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 38

198
type: Parameter
constant: false
value: 0.0
name: Integral_Fibrin

204
type: Parameter
is: SBO:0000035
constant: true
value: 0.0036
name: d_XIII

140
type: Reaction
kinetic law: 131329
reactant: 131317
fast: false
reversible: false
name: dVII_TF

020442
type: LocalParameter
is: SBO:0000035
value: 0.7
name: k1

131317
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 31

233
type: Event
event assignment: 132099
trigger: 132087
use values from trigger time: true
name: dilution event

132087
type: Trigger
persistant: true
initial value: true

131
type: Reaction
kinetic law: 131113
reactant: 131101
fast: false
reversible: false
name: dPg

131101
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 24

111
type: Reaction
kinetic law: 130616
product: 130604
reactant: 130592
fast: false
reversible: false
name: dXF

020411
type: LocalParameter
is: SBO:0000035
value: 0.05
name: k1

130604
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 47

130592
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 22

161
type: Reaction
kinetic law: 131859
product: 131847
fast: false
reversible: false
name: pV

131847
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 15

155
type: Reaction
kinetic law: 131714
reactant: 131702
fast: false
reversible: false
name: eHeparinIXa

131702
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 53

102
type: Reaction
kinetic law: 130288
modifier: 130276
product: 130264
reactant: 130252
fast: false
reversible: false
name: r48

130264
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 42

130252
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 44

216
type: Parameter
constant: true
value: 50.0
name: Tmod(0)

152
type: Reaction
kinetic law: 131641
product: 131629
reactant: 131617
fast: false
reversible: true
name: VK_transport

131629
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 54

131617
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 42

105
type: Reaction
kinetic law: 130398
modifier: 130386
product: 130374
fast: false
reversible: false
name: pIX_VKH2

130374
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 5

120
type: Reaction
kinetic law: 130846
reactant: 130834
fast: false
reversible: false
name: dVIIIa

020421
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

130834
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 3

123
type: Reaction
kinetic law: 130919
reactant: 130906
fast: false
reversible: false
name: dIX

130906
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 5

61
type: Reaction
kinetic law: 128335
modifier: 128323
product: 128310
reactant: 128298
fast: false
reversible: false
name: r7

020294
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

020293
type: LocalParameter
is: SBO:0000025
value: 0.02
name: v

128310
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 13

128298
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 12

190
type: Parameter
constant: true
value: 0.1
name: VKO(0)

116
type: Reaction
kinetic law: 130749
reactant: 130737
fast: false
reversible: false
name: dVa

020416
type: LocalParameter
is: SBO:0000035
value: 20.0
name: k1

130737
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 16

70
type: Reaction
kinetic law: 128758
modifier: 128746
product: 128734
reactant: 128722
fast: false
reversible: false
name: r16

020326
type: LocalParameter
is: SBO:0000371
value: 10.0
name: k

020324
type: LocalParameter
is: SBO:0000025
value: 7.0
name: v

128734
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 22

128722
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 18

55
type: Reaction
kinetic law: 128057
modifier: 128045
product: 128033
reactant: 128021
fast: false
reversible: false
name: r1

020276
type: LocalParameter
is: SBO:0000371
value: 1.0E-6
name: k

020274
type: LocalParameter
is: SBO:0000025
value: 50000.0
name: v

128033
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 3

128021
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 2

174
type: Parameter
constant: true
value: 89.6
name: IX(0)

177
type: Parameter
constant: true
value: 300.0
name: PS(0)

73
type: Reaction
kinetic law: 128902
modifier: 128890
product: 128878
reactant: 128866
fast: false
reversible: false
name: r19

020336
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020334
type: LocalParameter
is: SBO:0000025
value: 1.0
name: v

128878
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 47

128866
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 22

184
type: Parameter
is: SBO:0000035
constant: true
value: 0.0165
name: d_PS

137
type: Reaction
kinetic law: 131257
reactant: 131245
fast: false
reversible: false
name: dD

020438
type: LocalParameter
is: SBO:0000035
value: 0.1
name: k1

131245
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 47

90
type: Reaction
kinetic law: 129711
modifier: 129699
product: 129687
reactant: 129675
fast: false
reversible: false
name: r36

020374
type: LocalParameter
is: SBO:0000371
value: 1.0
name: k

020373
type: LocalParameter
is: SBO:0000025
value: 1000.0
name: v

129687
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 30

129675
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 31

128
type: Reaction
kinetic law: 131041
reactant: 131029
fast: false
reversible: false
name: dXIIIa

020429
type: LocalParameter
is: SBO:0000035
value: 0.69
name: k1

131029
type: SpeciesReference
is: SBO:0000010
stoichiometry: 1.0
species: 50

158
type: Reaction
kinetic law: 131787
product: 131775
fast: false
reversible: false
name: pXII

131775
type: SpeciesReference
is: SBO:0000011
stoichiometry: 1.0
species: 38

W3 CDTF: Fri Apr 20 22:45:59 BST 2012

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert