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notes: This model is from the article: A mathematical model of lipid-mediated thrombin generation Bungay Sharene D., Gentry Patricia A., Gentry Rodney D. Mathematical Medicine and Biology Volume 20, Issue 1, 1 March 2003, Pages 105-29 12974500 , Abstract: Thrombin is an enzyme that is generated in both vascular and non-vascular systems. In blood coagulation, a fundamental process in all species, thrombin induces the formation of a fibrin clot. A dynamical model of thrombin generation in the presence of lipid surfaces is presented. This model also includes the self-regulating thrombin feedback reactions, the thrombomodulin-protein C-protein S inhibitory system, tissue factor pathway inhibitor (TFPI), and the inhibitor, antithrombin (AT). The dynamics of this complex system were found to be highly lipid dependent, as would be expected from experimental studies. Simulations of this model indicate that a threshold lipid level is required to generate physiologically relevant amounts of thrombin. The dependence of the onset, the peak levels, and the duration of thrombin generation on lipid was saturable. The lipid concentration affects the way in which the inhibitors modulate thrombin production. A novel feature of this model is the inclusion of the dynamical protein C pathway, initiated by thrombin feedback. This inhibitory system exerts its effects on the lipid surface, where its substrates are formed. The maximum impact of TFPI occurs at intermediate vesicle concentrations. Inhibition by AT is only indirectly affected by the lipid since AT irreversibly binds only to solution phase proteins. In a system with normal plasma concentrations of the proteins involved in thrombin formation, the combination of these three inhibitors is sufficient both to effectively stop thrombin generation prior to the exhaustion of its precursor, prothrombin, and to inhibit all thrombin formed. This model can be used to predict thrombin generation under extreme lipid conditions that are difficult to…
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is described by: http://identifiers.org/pubmed/12974500
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metaid_0000075
type: Parameter
constant: true
value: 66.0

metaid_0000183
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000114
name: TM_l

metaid_0000096
type: Parameter
constant: true
value: 6.83E-5

metaid_0000056
type: Parameter
constant: true
value: 1.0

metaid_0000211
type: Reaction
kinetic law: 978617
product: 978605
product: 978593
reactant: 978581
fast: false
reversible: false
name: Factor Xa release

978605
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

978593
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

978581
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

metaid_0000003
type: Parameter
constant: true
value: 0.0043

metaid_0000017
type: Parameter
constant: true
value: 0.05

metaid_0000098
type: Parameter
constant: true
value: 6.94

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

metaid_0000111
type: Parameter
constant: true
value: 0.01

metaid_0000010
type: Parameter
constant: true
value: 0.145

metaid_0000045
type: Parameter
constant: true
value: 0.34

metaid_0000036
type: Parameter
constant: true
value: 0.17

metaid_0000207
type: Reaction
kinetic law: 978436
product: 978424
reactant: 978412
reactant: 978400
fast: false
reversible: false
name: IX_TF_VIIa binding

978424
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000152

metaid_0000152
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_IX_l

978412
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

978400
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000132

metaid_0000052
type: Parameter
constant: true
value: 15.2

metaid_0000087
type: Parameter
constant: true
value: 0.1

metaid_0000078
type: Parameter
constant: true
value: 0.05

metaid_0000026
type: Parameter
constant: true
value: 1.9

metaid_0000025
type: Parameter
constant: true
value: 0.01

metaid_0000251
type: Reaction
kinetic law: 980543
product: 980531
reactant: 980519
reactant: 980507
fast: false
reversible: false

980531
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

980519
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000140

metaid_0000140
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_l

980507
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000142

metaid_0000142
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: PS_l

metaid_0000041
type: Parameter
constant: true
value: 0.005

metaid_0000032
type: Parameter
constant: true
value: 0.2

metaid_0000067
type: Parameter
constant: true
value: 6.94

metaid_0000074
type: Parameter
constant: true
value: 0.1

metaid_0000219
type: Reaction
kinetic law: 979007
product: 978995
product: 978983
reactant: 978970
fast: false
reversible: false
name: Factor V activation

978995
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

978983
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

978970
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000160

metaid_0000160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_Xa_l

metaid_0000231
type: Reaction
kinetic law: 979573
product: 979561
product: 979549
reactant: 979537
fast: false
reversible: false

979561
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

979549
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

979537
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000180

metaid_0000153
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_IXa_l

metaid_0000092
type: Parameter
constant: true
value: 0.01

metaid_0000021
type: Parameter
constant: true
value: 0.05

metaid_0000254
type: SBMLUnitsDef
unit: 977467
name: nano mole

977467
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000063
type: Parameter
constant: true
value: 0.1

metaid_0000084
type: Parameter
constant: true
value: 0.1

metaid_0000044
type: Parameter
constant: true
value: 2.09

metaid_0000119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: metaid_0000114
name: V_f

metaid_0000191
type: Reaction
kinetic law: 977660
product: 977648
reactant: 977636
reactant: 977624
fast: false
reversible: false
name: Factor Va lipid binding

977648
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

977636
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977624
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

metaid_0000121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Va_f

metaid_0000086
type: Parameter
constant: true
value: 0.4

metaid_0000243
type: Reaction
kinetic law: 980156
product: 980144
reactant: 980132
reactant: 980120
fast: false
reversible: false

980144
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000181

980132
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

980120
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000234
type: Reaction
kinetic law: 979717
product: 979705
reactant: 979693
reactant: 979681
fast: false
reversible: false

979705
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000171

metaid_0000171
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_PS_VIIIa_l

979693
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

979681
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

metaid_0000024
type: Parameter
constant: true
value: 0.115

metaid_0000198
type: Reaction
kinetic law: 978001
product: 977989
reactant: 977977
reactant: 977965
fast: false
reversible: false
name: Factor X lipid binding

977989
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000136

977977
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977965
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000135

metaid_0000135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 170.0
initial amount: NaN
in compartment: metaid_0000114
name: X_f

metaid_0000189
type: Reaction
kinetic law: 977564
product: 977552
reactant: 977540
reactant: 977528
fast: false
reversible: false
name: Factor mIIa lipid binding

977552
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

977540
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977528
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_f

metaid_0000040
type: Parameter
constant: true
value: 0.005

metaid_0000066
type: Parameter
constant: true
value: 0.1

metaid_0000247
type: Reaction
kinetic law: 980351
product: 980339
reactant: 980327
reactant: 980315
fast: false
reversible: false

980339
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000184

980327
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

980315
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000183

metaid_0000154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_X_l

metaid_0000230
type: Reaction
kinetic law: 979525
product: 979513
reactant: 979501
reactant: 979489
fast: false
reversible: false

979513
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000180

979501
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

979489
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000091
type: Parameter
constant: true
value: 3.3E-4

metaid_0000020
type: Parameter
constant: true
value: 0.335

metaid_0000194
type: Reaction
kinetic law: 977807
product: 977795
reactant: 977783
reactant: 977770
fast: false
reversible: false
name: Factor VIII lipid binding

977795
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

977783
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977770
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

metaid_0000127
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: metaid_0000114
name: VIII_f

metaid_0000169
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: XIa_l

metaid_0000227
type: Reaction
kinetic law: 979393
product: 979381
reactant: 979369
reactant: 979357
fast: false
reversible: false

979381
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000166

979369
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

979357
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000062
type: Parameter
constant: true
value: 0.043

metaid_0000210
type: Reaction
kinetic law: 978569
product: 978557
reactant: 978545
fast: false
reversible: false
name: Factor X activation

978557
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

978545
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

metaid_0000080
type: Parameter
constant: true
value: 15.2

metaid_0000071
type: Parameter
constant: true
value: 0.9

metaid_0000100
type: Parameter
constant: true
value: 0.1

metaid_0000190
type: Reaction
kinetic law: 977612
product: 977600
reactant: 977588
reactant: 977576
fast: false
reversible: false
name: Factor V lipid binding

977600
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

977588
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977576
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_Xa_TF_VIIa_l

metaid_0000242
type: Reaction
kinetic law: 980108
product: 980095
reactant: 980083
reactant: 980071
fast: false
reversible: false

980095
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000174

980083
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

980071
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000197
type: Reaction
kinetic law: 977953
product: 977940
reactant: 977927
reactant: 977915
fast: false
reversible: false
name: Factor IXa lipid binding

977940
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

metaid_0000134
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IXa_l

977927
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977915
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

metaid_0000015
type: Parameter
constant: true
value: 0.05

metaid_0000239
type: Reaction
kinetic law: 979959
product: 979947
reactant: 979934
reactant: 979922
fast: false
reversible: false

979947
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000176

979934
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000175

metaid_0000175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_Xa_l

979922
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

metaid_0000222
type: Reaction
kinetic law: 979152
product: 979139
reactant: 979127
reactant: 979115
fast: false
reversible: false

979139
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000163

979127
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

979115
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

metaid_0000009
type: Parameter
constant: true
value: 0.05

metaid_0000145
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Vai_f

metaid_0000083
type: Parameter
constant: true
value: 1.43

metaid_0000203
type: Reaction
kinetic law: 978244
product: 978231
reactant: 978219
reactant: 978207
fast: false
reversible: false
name: Factor Vai lipid binding

978231
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000146

978219
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

978207
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000145

metaid_0000187
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: XIa_IX_l

metaid_0000037
type: Parameter
constant: true
value: 0.05

metaid_0000235
type: Reaction
kinetic law: 979766
product: 979754
product: 979742
reactant: 979729
fast: false
reversible: false

979754
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

979742
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000144

979729
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000171

metaid_0000226
type: Reaction
kinetic law: 979345
product: 979332
reactant: 979320
reactant: 979308
fast: false
reversible: false

979332
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000165

979320
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

979308
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

metaid_0000116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: II_l

metaid_0000106
type: Parameter
constant: true
value: 6.4

metaid_0000005
type: Parameter
constant: true
value: 100.0

metaid_0000215
type: Reaction
kinetic law: 978812
product: 978800
reactant: 978788
reactant: 978776
fast: false
reversible: false
name: Va_Xa binding

978800
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

978788
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

978776
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

metaid_0000206
type: Reaction
kinetic law: 978388
product: 978376
reactant: 978364
reactant: 978352
fast: false
reversible: false
name: TF_VII binding

978376
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000151

metaid_0000151
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VII_l

978364
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

978352
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

metaid_0000013
type: Parameter
constant: true
value: 0.05

metaid_0000049
type: Parameter
constant: true
value: 1.0

metaid_0000193
type: Reaction
kinetic law: 977758
product: 977746
reactant: 977734
reactant: 977721
fast: false
reversible: false
name: Factor VIIa lipid binding

977746
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

977734
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977721
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000125

metaid_0000250
type: Reaction
kinetic law: 980495
product: 980483
reactant: 980471
reactant: 980459
fast: false
reversible: false

980483
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000186

980471
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

980459
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000238
type: Reaction
kinetic law: 979910
product: 979898
reactant: 979886
reactant: 979874
fast: false
reversible: false

979898
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000175

979886
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000172

979874
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

metaid_0000109
type: Parameter
constant: true
value: 0.1

metaid_0000095
type: Parameter
constant: true
value: 2.3E-6

metaid_0000061
type: Parameter
constant: true
value: 1.0

metaid_0000008
type: Parameter
constant: true
value: 0.475

metaid_0000055
type: Parameter
constant: true
value: 1.0

metaid_0000202
type: Reaction
kinetic law: 978195
product: 978183
reactant: 978171
reactant: 978159
fast: false
reversible: false
name: Factor VIIIai lipid binding

978183
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000144

978171
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

978159
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000143

metaid_0000201
type: Reaction
kinetic law: 978147
product: 978135
reactant: 978123
reactant: 978111
fast: false
reversible: false
name: PS lipid binding

978135
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000142

978123
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

978111
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000141

metaid_0000218
type: Reaction
kinetic law: 978958
product: 978946
reactant: 978934
reactant: 978922
fast: false
reversible: false
name: V_Xa binding

978946
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000160

978934
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

978922
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000097
type: Parameter
constant: true
value: 0.1

metaid_0000110
type: Parameter
constant: true
value: 0.5

metaid_0000035
type: Parameter
constant: true
value: 0.057

metaid_0000105
type: Parameter
constant: true
value: 0.1

metaid_0000051
type: Parameter
constant: true
value: 44.8

metaid_0000077
type: Parameter
constant: true
value: 15.0

metaid_0000058
type: Parameter
constant: true
value: 10.7

metaid_0000214
type: Reaction
kinetic law: 978764
product: 978752
reactant: 978740
reactant: 978727
fast: false
reversible: false
name: VIIIa_IXa binding

978752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000157

978740
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

978727
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

metaid_0000019
type: Parameter
constant: true
value: 0.05

metaid_0000031
type: Parameter
constant: true
value: 0.05

metaid_0000048
type: Parameter
constant: true
value: 1.5

metaid_0000113
type: Parameter
constant: true
value: 0.183

metaid_0000012
type: Parameter
constant: true
value: 0.17

metaid_0000047
type: Parameter
constant: true
value: 32.5

metaid_0000073
type: Parameter
constant: true
value: 100.0

metaid_0000209
type: Reaction
kinetic law: 978533
product: 978521
reactant: 978509
reactant: 978496
fast: false
reversible: false
name: X_TF_VIIa complex formation

978521
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

978509
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

978496
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000136

metaid_0000054
type: Parameter
constant: true
value: 0.2

metaid_0000089
type: Parameter
constant: true
value: 0.4

metaid_0000200
type: Reaction
kinetic law: 978099
product: 978087
reactant: 978075
reactant: 978063
fast: false
reversible: false
name: APC lipid binding

978087
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000140

978075
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

978063
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000139

metaid_0000028
type: Parameter
constant: true
value: 3.3

metaid_0000253
type: Reaction
kinetic law: 980639
product: 980627
product: 980615
reactant: 980603
fast: false
reversible: false

980627
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000169

980615
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

980603
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000187

metaid_0000043
type: Parameter
constant: true
value: 0.01

metaid_0000034
type: Parameter
constant: true
value: 0.335

metaid_0000069
type: Parameter
constant: true
value: 0.1

metaid_0000085
type: Parameter
constant: true
value: 1.6

metaid_0000076
type: Parameter
constant: true
value: 13.0

metaid_0000233
type: Reaction
kinetic law: 979669
product: 979657
product: 979645
reactant: 979633
fast: false
reversible: false

979657
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000169

979645
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

979633
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000168

metaid_0000094
type: Parameter
constant: true
value: 4.9E-7

metaid_0000023
type: Parameter
constant: true
value: 0.05

metaid_0000212
type: Reaction
kinetic law: 978665
product: 978653
reactant: 978641
reactant: 978629
fast: false
reversible: false
name: Xa_TF_VII binding

978653
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000156

978641
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000151

978629
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000188
type: Reaction
kinetic law: 977516
product: 977503
reactant: 977491
reactant: 977479
fast: false
reversible: false
name: Factor II lipid binding

977503
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

977491
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

977479
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000018
type: Parameter
constant: true
value: 0.1

metaid_0000030
type: Parameter
constant: true
value: 3.5

metaid_0000065
type: Parameter
constant: true
value: 0.023

metaid_0000046
type: Parameter
constant: true
value: 0.1

metaid_0000208
type: Reaction
kinetic law: 978484
product: 978472
product: 978460
reactant: 978448
fast: false
reversible: false
name: Factor IX activation

978472
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

978460
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

978448
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000152

metaid_0000090
type: Parameter
constant: true
value: 0.016

metaid_0000088
type: Parameter
constant: true
value: 1.6

metaid_0000246
type: Reaction
kinetic law: 980302
product: 980290
product: 980278
reactant: 980266
fast: false
reversible: false

980290
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

980278
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

980266
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000182

metaid_0000050
type: Parameter
constant: true
value: 0.05

metaid_0000245
type: Reaction
kinetic law: 980254
product: 980241
reactant: 980229
reactant: 980217
fast: false
reversible: false

980241
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000182

980229
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

980217
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

metaid_0000252
type: Reaction
kinetic law: 980591
product: 980579
reactant: 980567
reactant: 980555
fast: false
reversible: false

980579
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000187

980567
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000169

980555
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000132

metaid_0000070
type: Parameter
constant: true
value: 13.8

metaid_0000042
type: Parameter
constant: true
value: 0.005

metaid_0000068
type: Parameter
constant: true
value: 0.23

metaid_0000249
type: Reaction
kinetic law: 980447
product: 980435
product: 980423
reactant: 980411
fast: false
reversible: false

980435
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000184

980423
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000140

980411
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000185

metaid_0000241
type: Reaction
kinetic law: 980059
product: 980047
reactant: 980035
reactant: 980020
fast: false
reversible: false

980047
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000179

980035
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

980020
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000232
type: Reaction
kinetic law: 979621
product: 979609
reactant: 979597
reactant: 979585
fast: false
reversible: false

979609
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000168

979597
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000167

979585
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

metaid_0000072
type: Parameter
constant: true
value: 0.1

metaid_0000093
type: Parameter
constant: true
value: 0.0011

metaid_0000022
type: Parameter
constant: true
value: 0.115

W3 CDTF: Fri Apr 20 22:54:24 BST 2012

W3 CDTF: Tue Jan 08 18:06:42 GMT 2008