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notes: This model is from the article: Modelling thrombin generation in human ovarian follicular fluid Bungay Sharene D., Gentry Patricia A., Gentry Rodney D. Bulletin of Mathematical Biology Volume 68, Issue 8, 12 July 2006, Pages 2283-302 16838084 , Abstract: A mathematical model is constructed to study thrombin production in human ovarian follicular fluid. The model results show that the amount of thrombin that can be produced in ovarian follicular fluid is much lower than that in blood plasma, failing to reach the level required for fibrin formation, and thereby supporting the hypothesis that in follicular fluid thrombin functions to initiate cellular activities via intracellular signalling receptors. It is also concluded that the absence of the amplification pathway to thrombin production in follicular fluid is a major factor in restricting the amount of thrombin that can be produced. Titration of the initial concentrations of the various reactants in the model lead to predictions for the amount of tissue factor and phospholipid that is required to maintain thrombin production in the follicle, as well as to the conclusion that tissue factor pathway inhibitor has little effect on the time that thrombin generation is sustained. Numerical experiments to determine the effect of factor V, which is at a much reduced level in follicular fluid compared to plasma, and thrombomodulin, illustrate the importance for further experimental work to determine values for several parameters that have yet to be reported in the literature.
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name: VIII_l

910660
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

metaid_0000201
type: Reaction
kinetic law: 909590
product: 909578
reactant: 909566
reactant: 909554
fast: false
reversible: false
name: PS lipid binding

909578
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000142

metaid_0000142
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: PS_l

909566
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909554
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000141

metaid_0000141
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: metaid_0000114
name: PS_f

metaid_0000065
type: Parameter
constant: true
value: 0.023

metaid_0000190
type: Reaction
kinetic law: 909059
product: 909047
reactant: 909035
reactant: 909023
fast: false
reversible: false
name: Factor V lipid binding

909047
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

metaid_0000120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_l

909035
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909023
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000245
type: Reaction
kinetic law: 911713
product: 911701
reactant: 911689
reactant: 911677
fast: false
reversible: false

911701
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000182

metaid_0000182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIII_mIIa_l

911689
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

911677
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000118
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_l

metaid_0000238
type: Reaction
kinetic law: 911375
product: 911363
reactant: 911350
reactant: 911338
fast: false
reversible: false

911363
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000175

metaid_0000175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_Xa_l

911350
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000172

metaid_0000172
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_f

911338
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

metaid_0000137
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_f

metaid_0000013
type: Parameter
constant: true
value: 0.05

metaid_0000047
type: Parameter
constant: true
value: 32.5

metaid_0000204
type: Reaction
kinetic law: 909737
product: 909725
reactant: 909713
reactant: 909701
fast: false
reversible: false
name: PC lipid binding

909725
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000148

909713
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909701
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000147

metaid_0000072
type: Parameter
constant: true
value: 0.1

metaid_0000152
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_IX_l

metaid_0000032
type: Parameter
constant: true
value: 0.2

metaid_0000230
type: Reaction
kinetic law: 910987
product: 910975
reactant: 910963
reactant: 910951
fast: false
reversible: false

910975
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000180

metaid_0000180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VII_Xa_l

910963
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

910951
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 170.0
initial amount: NaN
in compartment: metaid_0000114
name: X_f

metaid_0000103
type: Parameter
constant: true
value: 1.0

metaid_0000027
type: Parameter
constant: true
value: 0.029

metaid_0000218
type: Reaction
kinetic law: 910407
product: 910395
reactant: 910383
reactant: 910371
fast: false
reversible: false
name: V_Xa binding

910395
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000160

910383
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

910371
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000061
type: Parameter
constant: true
value: 1.0

metaid_0000163
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_IIa_l

metaid_0000012
type: Parameter
constant: true
value: 0.17

metaid_0000210
type: Reaction
kinetic law: 910018
product: 910006
reactant: 909994
fast: false
reversible: false
name: Factor X activation

910006
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

metaid_0000155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_Xa_l

909994
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

metaid_0000154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_X_l

metaid_0000125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000114
name: VIIa_f

metaid_0000077
type: Parameter
constant: true
value: 15.0

metaid_0000200
type: Reaction
kinetic law: 909542
product: 909530
reactant: 909518
reactant: 909506
fast: false
reversible: false
name: APC lipid binding

909530
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000140

909518
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909506
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000139

metaid_0000139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_f

metaid_0000262
type: Reaction
kinetic law: 912199
product: 912187
reactant: 912175
reactant: 912163
fast: false
reversible: false
name: R33

912187
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000256

912175
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

912163
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000255

metaid_0000255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2600.0
initial amount: NaN
in compartment: metaid_0000114
name: alpha2M_l

metaid_0000244
type: Reaction
kinetic law: 911664
product: 911652
product: 911640
reactant: 911628
fast: false
reversible: false

911652
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

911640
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

911628
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000181

metaid_0000181
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_mIIa_l

metaid_0000111
type: Parameter
constant: true
value: 0.01

metaid_0000046
type: Parameter
constant: true
value: 0.1

metaid_0000254
type: SBMLUnitsDef
unit: 908914
name: nano mole

908914
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

W3 CDTF: Thu May 12 13:58:49 BST 2011

metaid_0000209
type: Reaction
kinetic law: 909982
product: 909970
reactant: 909958
reactant: 909945
fast: false
reversible: false
name: X_TF_VIIa complex formation

909970
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

909958
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

909945
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000136

metaid_0000214
type: Reaction
kinetic law: 910210
product: 910198
reactant: 910186
reactant: 910174
fast: false
reversible: false
name: VIIIa_IXa binding

910198
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000157

910186
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

910174
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

metaid_0000039
type: Parameter
constant: true
value: 0.5

metaid_0000073
type: Parameter
constant: true
value: 100.0

metaid_0000026
type: Parameter
constant: true
value: 1.9

metaid_0000178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IXa_AT_f

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

metaid_0000093
type: Parameter
constant: true
value: 0.0011

metaid_0000092
type: Parameter
constant: true
value: 0.01

metaid_0000053
type: Parameter
constant: true
value: 0.1

metaid_0000087
type: Parameter
constant: true
value: 0.1

metaid_0000100
type: Parameter
constant: true
value: 0.1

metaid_0000035
type: Parameter
constant: true
value: 0.057

metaid_0000233
type: Reaction
kinetic law: 911131
product: 911119
product: 911107
reactant: 911095
fast: false
reversible: false

911119
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000169

911107
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

911095
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000168

metaid_0000226
type: Reaction
kinetic law: 910795
product: 910783
reactant: 910770
reactant: 910758
fast: false
reversible: false

910783
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000165

910770
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

910758
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

metaid_0000208
type: Reaction
kinetic law: 909933
product: 909921
product: 909909
reactant: 909897
fast: false
reversible: false
name: Factor IX activation

909921
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

909909
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

909897
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000152

metaid_0000038
type: Parameter
constant: true
value: 11.5

metaid_0000067
type: Parameter
constant: true
value: 6.94

metaid_0000193
type: Reaction
kinetic law: 909205
product: 909193
reactant: 909180
reactant: 909168
fast: false
reversible: false
name: Factor VIIa lipid binding

909193
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

909180
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909168
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000125

metaid_0000015
type: Parameter
constant: true
value: 0.05

metaid_0000206
type: Reaction
kinetic law: 909835
product: 909823
reactant: 909811
reactant: 909799
fast: false
reversible: false
name: TF_VII binding

909823
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000151

909811
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

909799
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

metaid_0000105
type: Parameter
constant: true
value: 0.1

metaid_0000086
type: Parameter
constant: true
value: 0.4

metaid_0000250
type: Reaction
kinetic law: 911956
product: 911944
reactant: 911932
reactant: 911920
fast: false
reversible: false

911944
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000186

911932
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_f

911920
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000063
type: Parameter
constant: true
value: 0.1

metaid_0000127
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: metaid_0000114
name: VIII_f

metaid_0000202
type: Reaction
kinetic law: 909639
product: 909627
reactant: 909615
reactant: 909603
fast: false
reversible: false
name: Factor VIIIai lipid binding

909627
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000144

metaid_0000144
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIIai_l

909615
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909603
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000143

metaid_0000143
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIIai_f

metaid_0000066
type: Parameter
constant: true
value: 0.1

metaid_0000246
type: Reaction
kinetic law: 911761
product: 911749
product: 911737
reactant: 911725
fast: false
reversible: false

911749
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

911737
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

911725
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000182

metaid_0000014
type: Parameter
constant: true
value: 0.66

metaid_0000048
type: Parameter
constant: true
value: 1.5

metaid_0000075
type: Parameter
constant: true
value: 66.0

metaid_0000028
type: Parameter
constant: true
value: 3.3

metaid_0000062
type: Parameter
constant: true
value: 0.043

metaid_0000078
type: Parameter
constant: true
value: 0.05

metaid_0000095
type: Parameter
constant: true
value: 2.3E-6

metaid_0000055
type: Parameter
constant: true
value: 1.0

metaid_0000024
type: Parameter
constant: true
value: 0.115

metaid_0000222
type: Reaction
kinetic law: 910600
product: 910588
reactant: 910576
reactant: 910564
fast: false
reversible: false

910588
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000163

910576
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

910564
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

metaid_0000074
type: Parameter
constant: true
value: 0.1

metaid_0000090
type: Parameter
constant: true
value: 0.016

metaid_0000051
type: Parameter
constant: true
value: 44.8

metaid_0000069
type: Parameter
constant: true
value: 0.1

metaid_0000094
type: Parameter
constant: true
value: 4.9E-7

metaid_0000054
type: Parameter
constant: true
value: 0.2

metaid_0000088
type: Parameter
constant: true
value: 1.6

metaid_0000036
type: Parameter
constant: true
value: 0.17

metaid_0000234
type: Reaction
kinetic law: 911180
product: 911168
reactant: 911156
reactant: 911143
fast: false
reversible: false

911168
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000171

911156
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

911143
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

metaid_0000129
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIIa_f

metaid_0000263
type: Reaction
kinetic law: 912247
product: 912235
reactant: 912223
reactant: 912211
fast: false
reversible: false
name: R34

912235
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000257

metaid_0000257
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: alpha2M_Xa_l

912223
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

912211
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000255

metaid_0000189
type: Reaction
kinetic law: 909011
product: 908999
reactant: 908987
reactant: 908975
fast: false
reversible: false
name: Factor mIIa lipid binding

908999
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

908987
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

908975
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000017
type: Parameter
constant: true
value: 0.05

metaid_0000016
type: Parameter
constant: true
value: 0.227

metaid_0000112
type: Parameter
constant: true
value: 1.417

metaid_0000050
type: Parameter
constant: true
value: 0.05

metaid_0000045
type: Parameter
constant: true
value: 0.34

metaid_0000243
type: Reaction
kinetic law: 911616
product: 911604
reactant: 911592
reactant: 911580
fast: false
reversible: false

911604
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000181

911592
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

911580
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000153
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_IXa_l

W3 CDTF: Fri Apr 20 22:55:14 BST 2012

metaid_0000198
type: Reaction
kinetic law: 909446
product: 909434
reactant: 909422
reactant: 909409
fast: false
reversible: false
name: Factor X lipid binding

909434
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000136

909422
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909409
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000135

metaid_0000064
type: Parameter
constant: true
value: 2.1

metaid_0000080
type: Parameter
constant: true
value: 15.2

metaid_0000029
type: Parameter
constant: true
value: 0.05

metaid_0000041
type: Parameter
constant: true
value: 0.005

metaid_0000194
type: Reaction
kinetic law: 909253
product: 909241
reactant: 909229
reactant: 909217
fast: false
reversible: false
name: Factor VIII lipid binding

909241
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

909229
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909217
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

metaid_0000057
type: Parameter
constant: true
value: 0.1

metaid_0000009
type: Parameter
constant: true
value: 0.05

metaid_0000021
type: Parameter
constant: true
value: 0.05

metaid_0000207
type: Reaction
kinetic law: 909884
product: 909872
reactant: 909860
reactant: 909848
fast: false
reversible: false
name: IX_TF_VIIa binding

909872
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000152

909860
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

909848
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000132

metaid_0000003
type: Parameter
constant: true
value: 0.0043

metaid_0000076
type: Parameter
constant: true
value: 13.0

metaid_0000179
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_AT_f

metaid_0000251
type: Reaction
kinetic law: 912006
product: 911994
reactant: 911982
reactant: 911969
fast: false
reversible: false

911994
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

911982
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000140

911969
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000142

metaid_0000096
type: Parameter
constant: true
value: 6.83E-6

metaid_0000259
type: Parameter
constant: true
value: 2.5E-6

metaid_0000056
type: Parameter
constant: true
value: 1.0

metaid_0000005
type: Parameter
constant: true
value: 100.0

metaid_0000258
type: Parameter
constant: true
value: 2.3E-6

metaid_0000239
type: Reaction
kinetic law: 911423
product: 911411
reactant: 911399
reactant: 911387
fast: false
reversible: false

911411
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000176

911399
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000175

911387
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

metaid_0000033
type: Parameter
constant: true
value: 0.05

metaid_0000231
type: Reaction
kinetic law: 911035
product: 911023
product: 911011
reactant: 910999
fast: false
reversible: false

911023
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

911011
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

910999
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000180

metaid_0000109
type: Parameter
constant: true
value: 0.1

metaid_0000019
type: Parameter
constant: true
value: 0.05

metaid_0000091
type: Parameter
constant: true
value: 3.3E-4

metaid_0000052
type: Parameter
constant: true
value: 15.2

metaid_0000235
type: Reaction
kinetic law: 911228
product: 911216
product: 911204
reactant: 911192
fast: false
reversible: false

911216
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

911204
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000144

911192
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000171

metaid_0000183
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000114
name: TM_l

metaid_0000097
type: Parameter
constant: true
value: 0.1

metaid_0000083
type: Parameter
constant: true
value: 1.43

metaid_0000215
type: Reaction
kinetic law: 910259
product: 910246
reactant: 910234
reactant: 910222
fast: false
reversible: false
name: Va_Xa binding

910246
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

910234
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

910222
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

metaid_0000043
type: Parameter
constant: true
value: 0.01

metaid_0000079
type: Parameter
constant: true
value: 44.8

metaid_0000241
type: Reaction
kinetic law: 911519
product: 911507
reactant: 911495
reactant: 911483
fast: false
reversible: false

911507
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000179

911495
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

911483
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000018
type: Parameter
constant: true
value: 0.1

metaid_0000113
type: Parameter
constant: true
value: 0.183

metaid_0000196
type: Reaction
kinetic law: 909349
product: 909337
reactant: 909325
reactant: 909313
fast: false
reversible: false
name: Factor IX lipid binding

909337
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000132

909325
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909313
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000131

metaid_0000131
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 90.0
initial amount: NaN
in compartment: metaid_0000114
name: IX_f

metaid_0000247
type: Reaction
kinetic law: 911810
product: 911798
reactant: 911786
reactant: 911773
fast: false
reversible: false

911798
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000184

911786
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

911773
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000183

metaid_0000023
type: Parameter
constant: true
value: 0.05

metaid_0000059
type: Parameter
constant: true
value: 8.3

metaid_0000221
type: Reaction
kinetic law: 910552
product: 910539
product: 910527
reactant: 910515
fast: false
reversible: false
name: Factor VIII activation

910539
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

910527
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

910515
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

metaid_0000199
type: Reaction
kinetic law: 909494
product: 909482
reactant: 909470
reactant: 909458
fast: false
reversible: false
name: Factor Xa lipid binding

909482
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

909470
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909458
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

metaid_0000211
type: Reaction
kinetic law: 910066
product: 910054
product: 910042
reactant: 910030
fast: false
reversible: false
name: Factor Xa release

910054
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

910042
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

910030
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

metaid_0000227
type: Reaction
kinetic law: 910843
product: 910831
reactant: 910819
reactant: 910807
fast: false
reversible: false

910831
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000166

910819
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

910807
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000253
type: Reaction
kinetic law: 912102
product: 912090
product: 912078
reactant: 912066
fast: false
reversible: false

912090
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000169

912078
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

912066
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000187

metaid_0000082
type: Parameter
constant: true
value: 10.0

metaid_0000081
type: Parameter
constant: true
value: 0.1

metaid_0000240
type: Reaction
kinetic law: 911471
product: 911459
reactant: 911447
reactant: 911435
fast: false
reversible: false

911459
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000178

911447
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

911435
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000042
type: Parameter
constant: true
value: 0.005

metaid_0000007
type: Parameter
constant: true
value: 0.05

metaid_0000195
type: Reaction
kinetic law: 909301
product: 909289
reactant: 909277
reactant: 909265
fast: false
reversible: false
name: Factor VIIIa lipid binding

909289
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

909277
type: SpeciesReference
stoichiometry: 100.0
species: metaid_0000004

909265
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000129

metaid_0000220
type: Reaction
kinetic law: 910503
product: 910491
reactant: 910479
reactant: 910467
fast: false
reversible: false
name: Xa_VIII binding

910491
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

910479
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

910467
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000022
type: Parameter
constant: true
value: 0.115

metaid_0000058
type: Parameter
constant: true
value: 10.7

metaid_0000106
type: Parameter
constant: true
value: 6.4

metaid_0000223
type: Reaction
kinetic law: 910648
product: 910636
product: 910624
reactant: 910612
fast: false
reversible: false

910636
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

910624
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

910612
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000163