BIOMD0000000330
type: SBMLModel
rule: metaid_0000026
species: metaid_0000008
parameter: metaid_0000018
parameter: metaid_0000128
substance units: 858204
compartment: metaid_0000004
time units: 858180
parameter: metaid_0000025
species: metaid_0000007
parameter: metaid_0000020
is version of: GO:0019722
modified:
  W3 CDTF: Mon Jul 11 13:48:35 BST 2011
parameter: metaid_0000012
parameter: metaid_0000019
notes: This model is from the article: On the encoding and decoding of calcium signals in hepatocytes Ann Zahle Larsen, Lars Folke Olsen and Ursula Kummera Biophysical Chemistry Volume 107, Issue 1, 1 January 2004, Pages 83-99 14871603 , Abstract: Many different agonists use calcium as a second messenger. Despite intensive research in intracellular calcium signalling it is an unsolved riddle how the different types of information represented by the different agonists, is encoded using the universal carrier calcium. It is also still not clear how the information encoded is decoded again into the intracellular specific information at the site of enzymes and genes. After the discovery of calcium oscillations, one likely mechanism is that information is encoded in the frequency, amplitude and waveform of the oscillations. This hypothesis has received some experimental support. However, the mechanism of decoding of oscillatory signals is still not known. Here, we study a mechanistic model of calcium oscillations, which is able to reproduce both spiking and bursting calcium oscillations. We use the model to study the decoding of calcium signals on the basis of co-operativity of calcium binding to various proteins. We show that this co-operativity offers a simple way to decode different calcium dynamics into different enzyme activities. Note: This model corresponds to the 5 variable receptor-operated model, as described by Larsen et al., 2004. This model is a modified version of the model described in Kummer 2000 (PMID: 10968983 )
created:
  W3 CDTF: Thu May 05 13:59:47 BST 2011
parameter: metaid_0000013
is described by: http://identifiers.org/pubmed/14871603
parameter: metaid_0000129
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occurs in: http://identifiers.org/taxonomy/10116
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parameter: metaid_0000011
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compartment: metaid_0000030
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volume units: 858228
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compartment: metaid_0000003
curated: true
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length unit: length
occurs in: CL:0000182
rule: metaid_0000029
is: MODEL1105060001
name: Larsen2004_CalciumSpiking
parameter: metaid_0000010
parameter: metaid_0000009
area units: area
species: metaid_0000006
parameter: metaid_0000015
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
parameter: metaid_0000021
parameter: metaid_0000014

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