BIOMD0000000324
type: SBMLModel
parameter: 249413
units def: 759899
parameter: 249422
parameter: 249425
name: Morris1981_MuscleFibre_Voltage_full
volume units: 749163
compartment: 249390
parameter: 249416
has version: GO:0005249
parameter: 249428
rule: 249393
rule: 249394
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units def: 759827
parameter: 249434
parameter: 249437
parameter: 249410
is: MODEL1011230001
parameter: 249446
parameter: 249419
parameter: 249449
rule: 249405
time units: 759753
modified:
  W3 CDTF: Thu Mar 31 01:49:12 BST 2011
is described by: http://identifiers.org/pubmed/7260316
occurs in: http://identifiers.org/taxonomy/6678
units def: 759803
parameter: 249455
notes: This is the full model (eq. 1 and 2) of the voltage oscillations in barnacle muscle fibers described in the article: Voltage oscillations in the barnacle giant muscle fiber. Morris C, Lecar H. Biophys J. 1981 Jul;35(1):193-213. PubmedID: 7260316 ; DOI: 10.1016/S0006-3495(81)84782-0 Abstract: Barnacle muscle fibers subjected to constant current stimulation produce a variety of types of oscillatory behavior when the internal medium contains the Ca++ chelator EGTA. Oscillations are abolished if Ca++ is removed from the external medium, or if the K+ conductance is blocked. Available voltage-clamp data indicate that the cell's active conductance systems are exceptionally simple. Given the complexity of barnacle fiber voltage behavior, this seems paradoxical. This paper presents an analysis of the possible modes of behavior available to a system of two noninactivating conductance mechanisms, and indicates a good correspondence to the types of behavior exhibited by barnacle fiber. The differential equations of a simple equivalent circuit for the fiber are dealt with by means of some of the mathematical techniques of nonlinear mechanics. General features of the system are (a) a propensity to produce damped or sustained oscillations over a rather broad parameter range, and (b) considerable latitude in the shape of the oscillatory potentials. It is concluded that for cells subject to changeable parameters (either from cell to cell or with time during cellular activity), a system dominated by two noninactivating conductances can exhibit varied oscillatory and bistable behavior. The model consists of the differential equations (1) and (2) given on pages 195 and 196 of the article. There is one typo in the equation for I in (1), g L (V L ) should be g L (V - V L ). This was changed in the SBML file. As there are no current values given, for reproducing the time courses in figure 6 an applied current of 50 uA was assumed. The legend for the broken and the full line in this figure…
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has version: GO:0005245
parameter: 249452
is version of: GO:0042391
created:
  W3 CDTF: Thu Mar 31 01:20:52 BST 2011
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