BIOMD0000000302
type: SBMLModel
compartment: 740161
rule: 740181
parameter: 740247
parameter: 740232
parameter: 740223
parameter: 740231
curated: true
parameter: 740235
parameter: 740226
parameter: 740206
rule: 740198
parameter: 740238
units def: 447752
time units: 447703
parameter: 740218
rule: 740197
parameter: 740240
rule: 740189
rule: 740169
units def: 447776
parameter: 740212
rule: 740185
parameter: 740203
parameter: 740216
rule: 740168
rule: 740188
rule: 740184
parameter: 740215
units def: 447703
rule: 740176
rule: 740172
parameter: 740245
rule: 740192
parameter: 740221
length unit: length
rule: 740175
rule: 740191
compartment: 740162
units def: 447812
parameter: 740248
parameter: 740233
parameter: 740224
name: Wang1996_Synaptic_Inhibition_Two_Neuron
parameter: 740236
parameter: 740227
parameter: 740207
volume units: metaid_0000008
parameter: 740210
parameter: 740201
parameter: 740219
rule: 740196
parameter: 740241
parameter: 740205
rule: 740179
rule: 740199
parameter: 740213
rule: 740195
units def: 447727
notes: This is a model of one presynaptic and one postsynaptic cell, as described in the article: Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model. Wang XJ, Buzsáki G. J Neurosci. 1996 Oct 15;16(20):6402-13. PMID: 8815919 ; Abstract: Fast neuronal oscillations (gamma, 20-80 Hz) have been observed in the neocortex and hippocampus during behavioral arousal. Using computer simulations, we investigated the hypothesis that such rhythmic activity can emerge in a random network of interconnected GABAergic fast-spiking interneurons. Specific conditions for the population synchronization, on properties of single cells and the circuit, were identified. These include the following: (1) that the amplitude of spike afterhyperpolarization be above the GABAA synaptic reversal potential; (2) that the ratio between the synaptic decay time constant and the oscillation period be sufficiently large; (3) that the effects of heterogeneities be modest because of a steep frequency-current relationship of fast-spiking neurons. Furthermore, using a population coherence measure, based on coincident firings of neural pairs, it is demonstrated that large-scale network synchronization requires a critical (minimal) average number of synaptic contacts per cell, which is not sensitive to the network size. By changing the GABAA synaptic maximal conductance, synaptic decay time constant, or the mean external excitatory drive to the network, the neuronal firing frequencies were gradually and monotonically varied. By contrast, the network synchronization was found to be high only within a frequency band coinciding with the gamma (20-80 Hz) range. We conclude that the GABAA synaptic transmission provides a suitable mechanism for synchronized gamma oscillations in a sparsely connected network of fast-spiking interneurons. In turn, the interneuronal network can presumably maintain subthreshold oscillations in principal cell populations and serve to synchronize discharges of s…
rule: 740167
rule: 740187
rule: 740183
parameter: 740228
rule: 740166
parameter: 740242
rule: 740182
parameter: 740246
area units: area
substance units: metaid_0000010
units def: 447848
parameter: 740222
rule: 740170
rule: 740190
parameter: 740239
parameter: 740225
occurs in: BTO:0000601
initial assignment: BIOMD0000000302#
is: MODEL1101240000
parameter: 740237

740161
type: Compartment
is: FMA:54527
occurs in: FMA:62493
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0

740247
type: Parameter
constant: false
units: 447776
value: NaN

447776
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unit: 447800
unit: 447788
name: microA_per_cm2

447800
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

447788
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: AMPERE

740232
type: Parameter
constant: true
units: 447727
value: 0.1

447727
type: SBMLUnitsDef
unit: 447740
name: per_ms

447740
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

740223
type: Parameter
constant: false
units: 447727
value: NaN

740231
type: Parameter
constant: false
units: dimensionless
value: NaN

740235
type: Parameter
constant: true
units: 447752
value: 0.0

447752
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unit: 447764
name: mV

447764
type: SBMLUnit
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scale: -3
multipler: 1.0
kind: VOLT

740226
type: Parameter
constant: false
units: 447776
value: NaN

740206
type: Parameter
is: SBO:0000259
constant: true
units: 447752
value: -90.0

740238
type: Parameter
constant: false
units: dimensionless
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447703
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name: ms

447715
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kind: SECOND

740218
type: Parameter
constant: false
units: 447727
value: NaN

740240
type: Parameter
constant: false
units: dimensionless
value: NaN

740212
type: Parameter
constant: true
units: 447776
value: 0.0

740203
type: Parameter
is: SBO:0000257
constant: true
units: 447848
value: 9.0

447848
type: SBMLUnitsDef
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unit: 447861
name: mS_per_cm2

447873
type: SBMLUnit
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447861
type: SBMLUnit
exponent: 1.0
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kind: SIEMENS

740216
type: Parameter
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constant: false
units: 447752
value: -64.0

740215
type: Parameter
constant: false
units: dimensionless
value: NaN

740245
type: Parameter
constant: false
units: 447727
value: NaN

740221
type: Parameter
constant: false
units: 447776
value: NaN

740162
type: Compartment
is: FMA:54527
occurs in: FMA:62493
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0

447812
type: SBMLUnitsDef
unit: 447836
unit: 447824
name: uF_per_cm2

447836
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exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

447824
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exponent: 1.0
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multipler: 1.0
kind: FARAD

740248
type: Parameter
constant: false
units: 447776
value: NaN

740233
type: Parameter
is: SBO:0000259
constant: false
units: 447752
value: -64.0

740224
type: Parameter
constant: false
units: 447727
value: NaN

740236
type: Parameter
constant: false
units: 447776
value: NaN

740227
type: Parameter
is: SBO:0000257
constant: true
units: 447848
value: 0.1

740207
type: Parameter
is: SBO:0000259
constant: true
units: 447752
value: -65.0

740210
type: Parameter
constant: true
units: dimensionless
value: 5.0

740201
type: Parameter
is: SBO:0000258
constant: true
units: 447812
value: 1.0

740219
type: Parameter
constant: false
units: 447727
value: NaN

740241
type: Parameter
constant: false
units: 447727
value: NaN

740205
type: Parameter
is: SBO:0000257
constant: true
units: 447848
value: 35.0

740213
type: Parameter
constant: false
units: 447776
value: NaN

740228
type: Parameter
constant: false
units: dimensionless
value: NaN

740242
type: Parameter
constant: false
units: 447727
value: NaN

740246
type: Parameter
constant: false
units: 447727
value: NaN

740222
type: Parameter
constant: false
units: dimensionless
value: NaN

740239
type: Parameter
constant: false
units: dimensionless
value: NaN

740225
type: Parameter
constant: false
units: 447776
value: NaN

740237
type: Parameter
constant: false
units: 447776
value: NaN

740217
type: Parameter
constant: false
units: 447727
value: NaN

740208
type: Parameter
is: SBO:0000259
constant: true
units: 447752
value: 55.0

740211
type: Parameter
constant: false
units: 447703
value: NaN

740202
type: Parameter
is: SBO:0000257
constant: true
units: 447848
value: 0.1

740214
type: Parameter
constant: false
units: dimensionless
value: NaN

740230
type: Parameter
constant: true
units: 447727
value: 12.0

740244
type: Parameter
constant: false
units: 447727
value: NaN

740220
type: Parameter
constant: false
units: 447727
value: NaN

740229
type: Parameter
constant: true
units: 447752
value: -75.0

740243
type: Parameter
constant: false
units: 447727
value: NaN

W3 CDTF: Mon Jan 24 00:42:22 GMT 2011

W3 CDTF: Thu Mar 17 01:47:34 GMT 2011

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler