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type: SBMLModel
time units: metaid_0000168
is version of: GO:0007623
rule: 964428
name: Leloup1999_CircadianRhythms_Neurospora
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parameter: 964441
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compartment: 964418
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
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occurs in: http://identifiers.org/taxonomy/5141
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notes: This a model from the article: Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora. Leloup JC, Gonze D, Goldbeter A. J Biol Rhythms. 1999 Dec;14(6):433-48. 10643740 , Abstract: We examine theoretical models for circadian oscillations based on transcriptional regulation in Drosophila and Neurospora. For Drosophila, the molecular model is based on the negative feedback exerted on the expression of the per and tim genes by the complex formed between the PER and TIM proteins. For Neurospora, similarly, the model relies on the feedback exerted on the expression of the frq gene by its protein product FRQ. In both models, sustained rhythmic variations in protein and mRNA levels occur in continuous darkness, in the form of limit cycle oscillations. The effect of light on circadian rhythms is taken into account in the models by considering that it triggers degradation of the TIM protein in Drosophila, and frq transcription in Neurospora. When incorporating the control exerted by light at the molecular level, we show that the models can account for the entrainment of circadian rhythms by light-dark cycles and for the damping of the oscillations in constant light, though such damping occurs more readily in the Drosophila model. The models account for the phase shifts induced by light pulses and allow the construction of phase response curves. These compare well with experimental results obtained in Drosophila. The model for Drosophila shows that when applied at the appropriate phase, light pulses of appropriate duration and magnitude can permanently or transiently suppress circadian rhythmicity. We investigate the effects of the magnitude of light-induced changes on oscillatory behavior. Finally, we discuss the common and distinctive features of circadian oscillations in the two organisms. This particular version of the model has been translated from equations 4a-4c (Neurospora). This model was taken from the CellML reposit…
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is described by: http://identifiers.org/pubmed/10643740
species: 083424
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modified:
  W3 CDTF: Tue Jan 18 12:23:47 GMT 2011
curated: true
created:
  W3 CDTF: Fri Jan 14 14:22:45 GMT 2011
creator:
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    orgname: EMBL-EBI
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