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parameter: 334945
is described by: http://identifiers.org/pubmed/13692276
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has version: REACT 1383.6
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species: 334658
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parameter: 334969
units def: 943966
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substance units: metaid_0000060
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species: 334613
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occurs in: http://identifiers.org/taxonomy/9606
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species: 334634
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reaction: 334731
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is: MODEL1010190002
reaction: 334743
species: 334598
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parameter: 334921
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notes: This model is described inthe article: Metabolic control mechanisms. 5. A solution for the equations representing interaction between glycolysis and respiration in ascites tumor cells. Britton Chance, David Garfinkel, Joseph Higgins and Benno Hess, J Biol Chem. 1960 35:2426-2439. PubmedID: 13692276 Abstract: The other papers of this series present experimental evidence for possible relationships between the kinetics of oxygen, glucose, adenosine diphosphate, adenosine triphosphate, and phosphate and those of the cytochromes and pyridine nucleotides of the ascites tumor cell. From these general experiments we are able to formulate, under the law of mass action, a minimum hypothesis under which the four metabolic regulations previously described can be observed. In brief, the system can be represented by the known enzyme systems, a relatively higher ADP affinity in respiration than in glycolysis, the mitochondrial membrane, a segregation of ATP into two compartments, and an ATP-utilizing system that is responsive to small decreases of the intracellular ADP level. The chemical equations for the pathway from glucose to oxygen are solved by a digital computer method so that the responses of the chemical equations and of the living cell can be accurately compared. For reasons already described, we greatly prefer a com- puter representation based upon a physical or chemical law representing the action of the system to a model simulating the operation of the chemical system but not based upon funda- mental laws for the reactions involved; such a representation would not adequately represent the kinetics of the system, as in an electric circuit network or in some types of hydraulic ana- logues. The model gives solutions of the reaction kinetics for three types of metabolism: 0 - 64s, metabolism of endogenous substrate 64s - 119s, metabolism of added glucose, illustrating the activated and inhibited aspects of glucose metabolism 119s - 153s, relief of glucose and oxygen inhib…
species: 334637
compartment: metaid cell
name: Chance1960_Glycolysis_Respiration
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rule: 334874
rule: 334817
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units def: 944014
reaction: 334704
species: 334625

334734
type: Reaction
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reactant: 944960
product: 944972
product: 944984
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reversible: false
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334778
type: LocalParameter
units: 944014
value: 7.5E12

944014
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name: per molar squared per second

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944038
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944026
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944948
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334655
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constant: false
name: (XI) low energy intermediate in oxidative phosphorylation
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metaid cell
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size: 1.0
spatial dimensions: 3.0
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944960
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334661
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944972
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334658
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944984
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334649
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944936
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334652
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334619
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name: (GPP) hexose diphosphate

334915
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334945
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334607
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334887
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name: relative GLU

334924
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334676
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name: (PPP) enzyme intermediate concerned in ATP utilization
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initial concentration: 1.0E-6
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has property: GO:0016887
initial amount: NaN

334957
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name: relative TP2

334930
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name: relative PGA

334936
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name: relative LAC

334664
type: Species
name: (XSP) phosphorylated intermediate in oxidative phosphorylation
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334939
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334969
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943966
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name: per molar per second

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943990
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943978
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334906
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name: relative ETG

334646
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name: (LAC) lactate
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334900
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name: relative GLP

334628
type: Species
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name: (DPN) extramitochondrial diphospyridine nucleotide
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is: CHEBI:15846
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initial concentration: 1.0E-4
is: C00003

334613
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initial amount: NaN
name: (ETZ) phosphofructokinase
initial concentration: 1.0E-5
is version of: IPR022463

943942
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334918
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334719
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944655
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334769
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value: 1.0E10

944642
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334637
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name: (DGA) 1,3 diphosphoglycerate
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initial amount: NaN

944680
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species: 334640

334640
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initial concentration: 0.0
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name: (PGA) 3 phosphoglycerate
constant: false
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is: CHEBI:17794
boundary condition: false
is: SBO:0000247

944668
type: SpeciesReference
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species: 334604

334604
type: Species
initial concentration: 5.0E-4
name: (TP1) adenosine triphosphate in store 1 (cytoplasm)
constant: false
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initial amount: NaN
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boundary condition: false
is: CHEBI:15422
has only substance units: false
is: SBO:0000247

334912
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constant: false
units: dimensionless
value: NaN
name: relative GAP

334689
type: Reaction
fast: false
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is part of: R00299
reversible: false
kinetic law: 944098
reactant: 944062
is part of: GO:0004396
is: SBO:0000177
product: 944086
reactant: 944074
name: reaction 1

334753
type: LocalParameter
units: 943966
value: 3.0E9

944062
type: SpeciesReference
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species: 334595

334595
type: Species
has only substance units: false
is: CHEBI:17234
boundary condition: false
name: (GLU) glucose
initial concentration: 0.0
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is: C00293
initial amount: NaN
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is: SBO:0000247

944086
type: SpeciesReference
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species: 334601

334601
type: Species
boundary condition: false
initial concentration: 0.0
has only substance units: false
has version: IPR001312
has part: CHEBI:17234
name: (ENG) hexokinase-glucose intermediate
in compartment: metaid cell
is: SBO:0000297
constant: false
initial amount: NaN

944074
type: SpeciesReference
stoichiometry: 1.0
species: 334598

334598
type: Species
is version of: IPR001312
constant: false
name: (ENZ) hexokinase
initial amount: NaN
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initial concentration: 1.0E-5
has property: GO:0004396
boundary condition: false
is: SBO:0000297
has only substance units: false

334903
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative ETZ

334966
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constant: false
units: dimensionless
value: NaN
name: relative PPP

334897
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative ADP

334792
type: Event
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trigger: 945344
use values from trigger time: true
name: addition of uncoupling agent

334670
type: Species
initial concentration: 0.0
initial amount: NaN
name: (DBP) dibromophenol
has only substance units: false
is: SBO:0000247
in compartment: metaid cell
constant: false
boundary condition: false
is: CHEBI:33625

945344
type: Trigger
persistant: true
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334728
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: 944876
is version of: R00703
reactant: 944838
reactant: 944826
reversible: false
is: SBO:0000200
product: 944851
is version of: GO:0004459
product: 944864
name: reaction 14
fast: false

334774
type: LocalParameter
units: 943966
value: 1.0E7

944838
type: SpeciesReference
stoichiometry: 1.0
species: 334628

944826
type: SpeciesReference
stoichiometry: 1.0
species: 334646

944851
type: SpeciesReference
stoichiometry: 1.0
species: 334643

334643
type: Species
boundary condition: false
constant: false
initial concentration: 0.001
initial amount: NaN
in compartment: metaid cell
is: C00022
name: (PYR) pyruvate
is: CHEBI:32816
has only substance units: false
is: SBO:0000247

944864
type: SpeciesReference
stoichiometry: 1.0
species: 334631

334631
type: Species
is: CHEBI:16908
has only substance units: false
constant: false
name: (DPH) extramitochondrial reduced diphospyridine nucleotide
is: SBO:0000247
is: C00004
in compartment: metaid cell
initial concentration: 1.0E-4
boundary condition: false
initial amount: NaN

334951
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative OXY

334634
type: Species
in compartment: metaid cell
has only substance units: false
initial concentration: 0.004
is: C00009
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:18367
name: (PID) inorganic phosphate

334888
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative ENZ

334963
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative PUE

334731
type: Reaction
reactant: 944900
reactant: 944888
is version of: GO:0042867
is: SBO:0000200
fast: false
product: 944912
kinetic law: 944924
reversible: false
name: reaction 15
has version: GO:0006099

944900
type: SpeciesReference
stoichiometry: 4.0
species: 334649

944888
type: SpeciesReference
stoichiometry: 1.0
species: 334643

944912
type: SpeciesReference
stoichiometry: 4.0
species: 334652

334777
type: LocalParameter
units: 943966
value: 2.0E7

334743
type: Reaction
fast: false
is: SBO:0000200
reactant: 945116
reversible: false
is version of: GO:0022900
name: reaction 19
kinetic law: 945152
modifier: 945140
product: 945128

945116
type: SpeciesReference
stoichiometry: 1.0
species: 334658

334783
type: LocalParameter
units: 943966
value: 1.2E8

945128
type: SpeciesReference
stoichiometry: 1.0
species: 334655

334610
type: Species
name: (GLP) glucose 6-phosphate
constant: false
is: C00092
initial concentration: 0.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
in compartment: metaid cell
is: CHEBI:4170

334921
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative DPH

334752
type: Reaction
is: SBO:0000330
product: 945296
product: 945284
fast: false
reactant: 945260
product: 945272
kinetic law: 945308
name: reaction 22
reversible: false
is version of: GO:0006200

945296
type: SpeciesReference
stoichiometry: 1.0
species: 334634

945284
type: SpeciesReference
stoichiometry: 1.0
species: 334673

334673
type: Species
is version of: CHEBI:16541
name: (PUE) enzyme concerned in ATP utilization
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000297
in compartment: metaid cell
initial concentration: 2.0E-6
initial amount: NaN
is version of: C00017

945260
type: SpeciesReference
stoichiometry: 1.0
species: 334676

945272
type: SpeciesReference
stoichiometry: 1.0
species: 334607

334788
type: LocalParameter
units: 943942
value: 2000000.0

334942
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative DIH

334704
type: Reaction
is part of: GO:0006127
fast: false
name: reaction 6
reversible: false
product: 944375
is version of: http://identifiers.org/ec-code/1.1.1.8
reactant: 944351
is version of: GO:0004367
kinetic law: 944399
product: 944387
reactant: 944363
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is: SBO:0000200

944375
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species: 334679

334679
type: Species
is: SBO:0000247
initial amount: NaN
in compartment: metaid cell
is: CHEBI:16221
boundary condition: false
name: (AGP) alpha-glycerophosphate
is: C00623
has only substance units: false
initial concentration: 0.0
constant: false

944351
type: SpeciesReference
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species: 334625

334625
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:16108
name: (DHA) dihydroxacetone phosphate
is: C00111
in compartment: metaid cell
initial concentration: 0.0
initial amount: NaN

334762
type: LocalParameter
units: 943966
value: 2.0E9

944387
type: SpeciesReference
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species: 334628

944363
type: SpeciesReference
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species: 334631

334954
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative XSP

334789
type: Event
event assignment: 945332
trigger: 945320
use values from trigger time: true
name: addition of glucose

945320
type: Trigger
persistant: true
initial value: true

334716
type: Reaction
product: 944618
name: reaction 10
reversible: false
reactant: 944606
is part of: GO:0008943
is part of: http://identifiers.org/ec-code/1.2.1.12
is: SBO:0000177
kinetic law: 944630
fast: false
reactant: 944593
is part of: R01061

944618
type: SpeciesReference
stoichiometry: 1.0
species: 334682

334682
type: Species
in compartment: metaid cell
name: (MOD) glyceraldehyde 3-phoshphate dehydrogenase-DPN complex
has version: IPR006424
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constant: false
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has only substance units: false
initial concentration: 5.0E-5
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944606
type: SpeciesReference
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species: 334628

334768
type: LocalParameter
units: 943966
value: 6.0E9

944593
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species: 334688

334688
type: Species
has only substance units: false
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is version of: IPR006424
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initial concentration: 0.0
has property: GO:0004365
name: (MOX) glyceraldehyde 3-phoshphate dehydrogenase
is: SBO:0000252
is version of: Q2TSD0
is version of: P04406
in compartment: metaid cell
constant: false

334695
type: Reaction
reactant: 944195
name: reaction 3
is part of: R04779
is: SBO:0000177
reversible: false
fast: false
reactant: 944183
is part of: http://identifiers.org/ec-code/2.7.1.4
is part of: GO:0008865
product: 944207
kinetic law: 944219

944195
type: SpeciesReference
stoichiometry: 1.0
species: 334613

944183
type: SpeciesReference
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species: 334610

944207
type: SpeciesReference
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species: 334616

334616
type: Species
has only substance units: false
constant: false
has version: IPR022463
is: SBO:0000297
initial amount: NaN
boundary condition: false
name: (ETG) phosphofructokinase intermediate
has part: CHEBI:4170
initial concentration: 0.0
in compartment: metaid cell
has property: GO:0008662

334757
type: LocalParameter
units: 943966
value: 4.0E10

334978
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative MOX

334710
type: Reaction
is part of: GO:0008943
is part of: R01061
product: 944496
reactant: 944472
kinetic law: 944520
product: 944508
is: SBO:0000176
name: reaction 8
reversible: false
fast: false
reactant: 944484
is part of: http://identifiers.org/ec-code/1.2.1.12

944496
type: SpeciesReference
stoichiometry: 1.0
species: 334685

334685
type: Species
name: (MOB) acyl enzyme intermediate of glyceraldehyde 3-phoshphate dehydrogenase
boundary condition: false
in compartment: metaid cell
has only substance units: false
initial concentration: 0.0
has property: GO:0004365
constant: false
has part: CHEBI:29052
initial amount: NaN
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has version: IPR006424

944472
type: SpeciesReference
stoichiometry: 1.0
species: 334622

334622
type: Species
is: CHEBI:29052
is: SBO:0000247
name: (GAP) glyceraldehyde 3-phosphate
boundary condition: false
initial amount: NaN
is: C00118
constant: false
in compartment: metaid cell
initial concentration: 0.0
has only substance units: false

334764
type: LocalParameter
units: 943966
value: 6.0E11

944508
type: SpeciesReference
stoichiometry: 1.0
species: 334631

944484
type: SpeciesReference
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species: 334682

334713
type: Reaction
is part of: R01061
is: SBO:0000216
reactant: 944532
reactant: 944544
product: 944556
is part of: GO:0008943
reversible: false
product: 944568
kinetic law: 944581
name: reaction 9
fast: false
is part of: http://identifiers.org/ec-code/1.2.1.12

944532
type: SpeciesReference
stoichiometry: 1.0
species: 334685

944544
type: SpeciesReference
stoichiometry: 1.0
species: 334634

944556
type: SpeciesReference
stoichiometry: 1.0
species: 334637

944568
type: SpeciesReference
stoichiometry: 1.0
species: 334688

334767
type: LocalParameter
units: 943966
value: 4.0E8

334891
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative ENG

334725
type: Reaction
is: SBO:0000200
reactant: 944778
kinetic law: 944814
is version of: http://identifiers.org/ec-code/1.1.1.27
is version of: GO:0004459
reversible: false
name: reaction 13
product: 944790
fast: false
is version of: R00703
product: 944802
reactant: 944766

944778
type: SpeciesReference
stoichiometry: 1.0
species: 334631

334773
type: LocalParameter
units: 943966
value: 5.0E8

944790
type: SpeciesReference
stoichiometry: 1.0
species: 334646

944802
type: SpeciesReference
stoichiometry: 1.0
species: 334628

944766
type: SpeciesReference
stoichiometry: 1.0
species: 334643

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

W3 CDTF: Sun Oct 10 11:10:10 BST 2010

334909
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative GPP

334960
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative DBP

334698
type: Reaction
kinetic law: 944291
fast: false
product: 944255
is part of: http://identifiers.org/ec-code/2.7.1.4
name: reaction 4
is: SBO:0000216
is part of: R04779
product: 944279
reactant: 944243
reversible: false
reactant: 944231
product: 944267
is part of: GO:0008865

334758
type: LocalParameter
units: 943966
value: 4.0E10

944255
type: SpeciesReference
stoichiometry: 1.0
species: 334619

944279
type: SpeciesReference
stoichiometry: 1.0
species: 334607

944243
type: SpeciesReference
stoichiometry: 1.0
species: 334604

944231
type: SpeciesReference
stoichiometry: 1.0
species: 334616

944267
type: SpeciesReference
stoichiometry: 1.0
species: 334613

334746
type: Reaction
fast: false
name: reaction 20
reversible: false
is version of: GO:0015867
reactant: 945164
kinetic law: 945200
modifier: 945188
product: 945176
is: SBO:0000185

945164
type: SpeciesReference
stoichiometry: 1.0
species: 334667

334667
type: Species
initial amount: NaN
is: CHEBI:15422
name: (TP2) adenosine triphosphate in store 2 (mitochondria)
boundary condition: false
is: SBO:0000247
in compartment: metaid cell
is: C00002
initial concentration: 5.0E-4
has only substance units: false
constant: false

334784
type: LocalParameter
units: 943966
value: 4000000.0

945176
type: SpeciesReference
stoichiometry: 1.0
species: 334604

334737
type: Reaction
fast: false
kinetic law: 945044
is part of: GO:0006119
name: reaction 17
reactant: 945020
reversible: false
is: SBO:0000216
reactant: 945008
product: 945032

334779
type: LocalParameter
units: 943966
value: 4.0E8

945020
type: SpeciesReference
stoichiometry: 1.0
species: 334634

945008
type: SpeciesReference
stoichiometry: 1.0
species: 334658

945032
type: SpeciesReference
stoichiometry: 1.0
species: 334664

334927
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative DGA

334749
type: Reaction
reactant: 945224
reversible: false
reactant: 945212
product: 945236
is: SBO:0000177
name: reaction 21
kinetic law: 945248
is version of: GO:0005524
fast: false

945224
type: SpeciesReference
stoichiometry: 1.0
species: 334673

945212
type: SpeciesReference
stoichiometry: 1.0
species: 334604

945236
type: SpeciesReference
stoichiometry: 1.0
species: 334676

334787
type: LocalParameter
units: 943966
value: 3.0E9

334707
type: Reaction
product: 944448
is: SBO:0000200
kinetic law: 944460
name: reaction 7
is version of: http://identifiers.org/ec-code/1.1.1.8
is version of: R00842
is version of: GO:0004367
is part of: GO:0006127
reversible: false
reactant: 944411
fast: false
reactant: 944424
product: 944436

944448
type: SpeciesReference
stoichiometry: 1.0
species: 334631

334763
type: LocalParameter
units: 943966
value: 8.0E7

944411
type: SpeciesReference
stoichiometry: 1.0
species: 334679

944424
type: SpeciesReference
stoichiometry: 1.0
species: 334628

944436
type: SpeciesReference
stoichiometry: 1.0
species: 334625

334701
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: 944303
name: reaction 5
is: SBO:0000376
kinetic law: 944339
product: 944315
product: 944327
is version of: GO:0004332
fast: false
is version of: R01068

944303
type: SpeciesReference
stoichiometry: 1.0
species: 334619

334759
type: LocalParameter
units: 943942
value: 100000.0

944315
type: SpeciesReference
stoichiometry: 1.0
species: 334622

944327
type: SpeciesReference
stoichiometry: 1.0
species: 334625

334692
type: Reaction
is: SBO:0000216
reactant: 944110
reversible: false
kinetic law: 944171
product: 944134
is part of: GO:0004396
fast: false
is part of: R00299
reactant: 944122
name: reaction 2
product: 944146
product: 944158
is part of: http://identifiers.org/ec-code/2.7.1.1

944110
type: SpeciesReference
stoichiometry: 1.0
species: 334601

334754
type: LocalParameter
units: 943966
value: 1.0E10

944134
type: SpeciesReference
stoichiometry: 1.0
species: 334607

944122
type: SpeciesReference
stoichiometry: 1.0
species: 334604

944146
type: SpeciesReference
stoichiometry: 1.0
species: 334610

944158
type: SpeciesReference
stoichiometry: 1.0
species: 334598

334948
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative XSI

334894
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative TP1

334740
type: Reaction
product: 945080
reactant: 945068
is part of: GO:0006119
reversible: false
kinetic law: 945104
product: 945092
name: reaction 18
reactant: 945056
fast: false
is: SBO:0000216

945080
type: SpeciesReference
stoichiometry: 1.0
species: 334667

945068
type: SpeciesReference
stoichiometry: 1.0
species: 334607

334782
type: LocalParameter
units: 943966
value: 1.5E10

945092
type: SpeciesReference
stoichiometry: 1.0
species: 334655

945056
type: SpeciesReference
stoichiometry: 1.0
species: 334664

334722
type: Reaction
reactant: 944718
has part: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000216
has version: R00200
has part: http://identifiers.org/ec-code/4.2.1.11
product: 944730
product: 944742
reactant: 944705
fast: false
kinetic law: 944754
name: reaction 12
has part: R00658
has version: GO:0004634
has version: GO:0004743
reversible: false

944718
type: SpeciesReference
stoichiometry: 1.0
species: 334607

944730
type: SpeciesReference
stoichiometry: 1.0
species: 334604

944742
type: SpeciesReference
stoichiometry: 1.0
species: 334643

944705
type: SpeciesReference
stoichiometry: 1.0
species: 334640

334772
type: LocalParameter
units: 943966
value: 5.0E9

334933
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative PYR

334972
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative MOD

334975
type: Parameter
constant: false
units: dimensionless
value: NaN
name: relative MOB

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

W3 CDTF: Wed Mar 16 03:53:21 GMT 2011