BIOMD0000000271
type: SBMLModel
occurs in: http://identifiers.org/taxonomy/39107
is part of: ko04630
species: 774458
length unit: length
modified:
  W3 CDTF: Tue Jan 31 13:10:43 GMT 2012
name: Becker2010_EpoR_CoreModel
parameter: 774490
creator:
  ORG:
    orgname: German Cancer Research Center
  n:
    given: Marcel
    family: Schilling
creator:
  ORG:
    orgname: Department of Systems Biology, Harvard Medical School, Boston, USA
  n:
    given: Verena
    family: Becker
species: 774461
parameter: metaid_0000031
parameter: metaid_0000033
units def: metaid_0000027
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
reaction: 774463
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volume units: 773761
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parameter: 774486
created:
  W3 CDTF: Wed May 26 17:12:55 BST 2010
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reaction: 774471
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parameter: 774480
species: 774455
species: 774457
species: 774460
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units def: metaid_0000028
reaction: 774472
reaction: 774466
notes: This is the core model described in the article: Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor Verena Becker, Marcel Schilling, Julie Bachmann, Ute Baumann, Andreas Raue, Thomas Maiwald, Jens Timmer and Ursula Klingmüller; Science Published Online May 20, 2010; DOI: 10.1126/science.1184913 PMID: 20488988 Abstract: Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input, covering a broad range of ligand concentrations. This relation solely depends on EpoR turnover independent of ligand binding, suggesting an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system. SBML model exported from PottersWheel. % PottersWheel model definition file function m = BeckerSchilling2010_EpoR_CoreModel() m = pwGetEmptyModel(); %% Meta information m.ID = 'BeckerSchilling2010_EpoR_CoreModel'; m.name = 'BeckerSchilling2010_EpoR_CoreModel'; m.description = 'BeckerSchilling2010_EpoR_CoreModel'; m.authors = {'Verena Becker',' Marcel Schilling'}; m.dates = {'2010'}; m.type = 'PW-2-0-42'; %% X: Dynamic variables % m = pwAddX(m, ID, startValue, type, minValue, maxValue, unit, compartment, name, description, typeOfStartValue) m = pwAddX(m, 'EpoR' , 516, 'fix' , 0, 10000, [], 'cell', [] , [] , [] , [] , 'protein.generic'); m = pwAddX(m, 'Epo' , 2030.19, 'global', 1890, 2310, [], …
reaction: 774465
reaction: 774468
compartment: 784453
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parameter: 774484
species: 774454
parameter: 774487
area units: metaid_0000005
parameter: 774481
parameter: 774483
occurs in: BTO:0001035
compartment: 794453
units def: metaid_0000026
time units: metaid_0000026
reaction: 774469
units def: metaid_0000029
curated: true
is described by: http://identifiers.org/pubmed/20488988
is part of: ko04640
compartment: 774453
reaction: 774462

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type: Species
name: Epo_EpoRi
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boundary condition: false
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is: SBO:0000297

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type: Compartment
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constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

774490
type: Parameter
is: SBO:0000356
constant: true
units: metaid_0000027
value: 0.0164042

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name: medium

metaid_0000031
type: Parameter
constant: false
value: NaN
name: Epo_medium

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type: Parameter
constant: false
value: NaN
name: Epo_cells

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kinetic law: 803846
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value: 0.00317871

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fast: false
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774455
type: Species
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name: Epo_EpoR
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is: SBO:0000338
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