BIOMD0000000270
type: SBMLModel
reaction: 451766
parameter: 451813
parameter: 451829
reaction: 451714
reaction: 451695
parameter: 291542
parameter: 291548
parameter: 451801
parameter: 451797
parameter: 451827
reaction: 451750
parameter: 451835
species: 451645
reaction: 451702
reaction: 451736
time units: 773736
species: 451634
volume units: 773761
notes: This is the distributive model described the article: Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann WD, Timmer J and Klingmueller U; Mol Syst Biol. 2009;5:334. PubmedID: 20029368 ; DOI: 10.1038/msb.2009.91 Abstract: Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. By combining quantitative data from erythropoietin-induced pathway activation in primary erythroid progenitor (colony-forming unit erythroid stage, CFU-E) cells with mathematical modelling, we predicted and experimentally confirmed a distributive ERK phosphorylation mechanism in CFU-E cells. Model analysis showed bow-tie-shaped signal processing and inherently transient signalling for cytokine-induced ERK signalling. Sensitivity analysis predicted that, through a feedback-mediated process, increasing one ERK isoform reduces activation of the other isoform, which was verified by protein over-expression. We calculated ERK activation for biochemically not addressable but physiologically relevant ligand concentrations showing that double-phosphorylated ERK1 attenuates proliferation beyond a certain activation level, whereas activated ERK2 enhances proliferation with saturation kinetics. Thus, we provide a quantitative link between earlier unobservable signalling dynamics and cell fate decisions. SBML model exported from PottersWheel on 2009-04-20 18:57:44. Below follows the source code for the model definition file in PottersWheel/Matlab: % PottersWheel model definition file function m = getModel() m = pwGetEmptyModel(); %% Meta information m.ID = 'ERK_distributive_model'; m.name = 'ERK_distributive_model'; m.description = 'ERK model calibrated to CFU-E as described in Schilling et al.'; m.authors = {'Marcel Schilling','…
reaction: 451724
species: 451659
has version: mmu04630
species: 451622
reaction: 451716
units def: 773992
parameter: 451845
parameter: 291518
parameter: 451799
parameter: 451811
reaction: 451752
compartment: 451619
parameter: 451837
reaction: 451704
species: 451677
reaction: 451693
reaction: 451740
rule: 291481
rule: 291478
species: 451683
name: Schilling2009_ERK_distributive
parameter: 291524
parameter: 451821
species: 451626
reaction: 451722
species: 451657
units def: 773895
species: 451620
parameter: 451843
units def: 773736
parameter: 291530
species: 451669
species: 451685
species: 451651
occurs in: http://identifiers.org/taxonomy/10090
reaction: 451754
species: 451681
species: 451628
parameter: 291539
reaction: 451742
length unit: length
species: 451624
reaction: 451728
rule: 291484
reaction: 451689
reaction: 451686
parameter: 451823
reaction: 451764
species: 451667
substance units: 773712
has version: GO:0000165
reaction: 451756
rule: 291480
is: MODEL1001120000
has version: GO:0004900
reaction: 451697
rule: 291489
species: 451632
reaction: 451744
reaction: 451691

451766
type: Reaction
kinetic law: 775672
product: 775660
fast: false
is version of: GO:0006470
reactant: 775648
is part of: REACT 12439.1
is version of: GO:0017017
is: SBO:0000216
reversible: false

775660
type: SpeciesReference
stoichiometry: 1.0
species: 451636

451636
type: Species
is version of: P63085
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 21.0
initial amount: NaN
in compartment: 451619

451619
type: Compartment
is version of: GO:0005623
is version of: FMA:83517
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

775648
type: SpeciesReference
stoichiometry: 1.0
species: 451667

451667
type: Species
has part: MOD:00048
is version of: C00562
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
has only substance units: false
constant: false
is version of: P63085
is: SBO:0000252
boundary condition: false

451813
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 15.5956

773968
type: SBMLUnitsDef
unit: 773980
name: per minute

773980
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

451829
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 0.0732724

451714
type: Reaction
modifier: 774573
reversible: false
is: SBO:0000330
is version of: http://identifiers.org/ec-code/3.1.3.48
reactant: 774549
kinetic law: 774585
product: 774561
fast: false
is version of: GO:0004725

451645
type: Species
has property: GO:0004725
is version of: P29351
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 0.0
boundary condition: false
in compartment: 451619

774549
type: SpeciesReference
stoichiometry: 1.0
species: 451640

451640
type: Species
is version of: C00562
boundary condition: false
initial concentration: 0.0
is: SBO:0000252
constant: false
has version: MOD:00048
in compartment: 451619
initial amount: NaN
is version of: P14753
has only substance units: false

774561
type: SpeciesReference
stoichiometry: 1.0
species: 451622

451622
type: Species
is version of: P14753
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 451619

451695
type: Reaction
kinetic law: 774245
product: 774233
reactant: 774220
is: SBO:0000397
fast: false
reversible: false

774233
type: SpeciesReference
stoichiometry: 1.0
species: 451671

451671
type: Species
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

774220
type: SpeciesReference
stoichiometry: 1.0
species: 451669

451669
type: Species
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

291542
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_pJAK2

773895
type: SBMLUnitsDef
unit: 773907
name: arb. units

773907
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

291548
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_SOS

451801
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 0.408408

773992
type: SBMLUnitsDef
unit: 774028
unit: 774016
unit: 774004
name: second order rate constant

774028
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

774016
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE

774004
type: SBMLUnit
exponent: -1.0
scale: 4
multipler: 1.0
kind: ITEM

451797
type: Parameter
is: SBO:0000036
constant: true
units: 773846
value: 0.0122149

773846
type: SBMLUnitsDef
unit: 773882
unit: 773870
unit: 773858
name: per min per (Uml)

773882
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

773870
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE

773858
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

451827
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 0.130937

451750
type: Reaction
kinetic law: 775335
is version of: http://identifiers.org/ec-code/2.7.12.2
is: SBO:0000216
fast: false
is version of: GO:0004708
reactant: 775299
modifier: 775323
reversible: false
product: 775311

775299
type: SpeciesReference
stoichiometry: 1.0
species: 451636

451653
type: Species
is version of: P31938
initial amount: NaN
has only substance units: false
has part: MOD:00048
is version of: C00562
has property: GO:0004709
initial concentration: 0.0
in compartment: 451619
boundary condition: false
constant: false
has part: MOD:00047
is: SBO:0000252

775311
type: SpeciesReference
stoichiometry: 1.0
species: 451667

451835
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 2.44361

451702
type: Reaction
kinetic law: 774355
product: 774343
reactant: 774331
is: SBO:0000397
fast: false
reversible: false

774343
type: SpeciesReference
stoichiometry: 1.0
species: 451677

451677
type: Species
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

774331
type: SpeciesReference
stoichiometry: 1.0
species: 451675

451675
type: Species
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

451736
type: Reaction
product: 775022
is version of: GO:0051389
is version of: GO:0006470
fast: false
kinetic law: 775034
reversible: false
is: SBO:0000330
reactant: 775010

775022
type: SpeciesReference
stoichiometry: 1.0
species: 451661

451661
type: Species
is version of: C00562
is: SBO:0000252
is version of: Q63932
initial amount: NaN
constant: false
in compartment: 451619
initial concentration: 0.0
boundary condition: false
has only substance units: false

775010
type: SpeciesReference
stoichiometry: 1.0
species: 451651

451651
type: Species
has version: MOD:00047
has only substance units: false
in compartment: 451619
is version of: Q63932
has property: GO:0004709
constant: false
boundary condition: false
has version: MOD:00048
initial amount: NaN
is version of: C00562
is: SBO:0000252
initial concentration: 0.0

773736
type: SBMLUnitsDef
unit: 773748
name: minutes

773748
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

451634
type: Species
is version of: Q63844
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.0
initial amount: NaN
in compartment: 451619

773761
type: SBMLUnitsDef
unit: 773774
name: ml

773774
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE

451724
type: Reaction
is version of: GO:0006470
kinetic law: 774804
fast: false
reactant: 774780
product: 774792
reversible: false
is: SBO:0000330
is version of: GO:0051390

774780
type: SpeciesReference
stoichiometry: 1.0
species: 451649

451649
type: Species
initial concentration: 0.0
constant: false
is version of: Q99N57
has version: MOD:00046
boundary condition: false
is homolog to: REACT 3158
has property: GO:0004709
in compartment: 451619
has only substance units: false
is: SBO:0000252
initial amount: NaN
is version of: C00562

774792
type: SpeciesReference
stoichiometry: 1.0
species: 451628

451628
type: Species
is version of: Q99N57
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.7719
initial amount: NaN
in compartment: 451619

451659
type: Species
initial concentration: 0.0
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: false
is version of: C00562
is version of: Q62245
constant: false
in compartment: 451619

451716
type: Reaction
is: SBO:0000330
fast: false
reactant: 774597
product: 774610
is version of: GO:0004725
modifier: 774622
is version of: http://identifiers.org/ec-code/3.1.3.48
kinetic law: 774634
reversible: false

774597
type: SpeciesReference
stoichiometry: 1.0
species: 451638

451638
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: 0.0
is homolog to: REACT_24029
boundary condition: false
is version of: C00562
is version of: Q62120
constant: false
in compartment: 451619
has version: MOD:00048
has property: GO:0004713

774610
type: SpeciesReference
stoichiometry: 1.0
species: 451620

451620
type: Species
is version of: Q62120
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 451619

451845
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 0.124944

291518
type: Parameter
is: SBO:0000381
constant: true
units: 773919
value: 13.5981
name: scale_ppERK

773919
type: SBMLUnitsDef
unit: 773956
unit: 773944
unit: 773931
name: arb. unit. per 10000 molecules

773956
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

773944
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE

773931
type: SBMLUnit
exponent: -1.0
scale: 4
multipler: 1.0
kind: ITEM

451799
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 3.15714

451811
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 0.10271

451752
type: Reaction
is part of: REACT 136.4
is version of: http://identifiers.org/ec-code/2.7.12.2
reactant: 775347
is version of: GO:0000187
product: 775359
is version of: GO:0004708
reversible: false
kinetic law: 775384
is: SBO:0000216
fast: false
modifier: 775371

775347
type: SpeciesReference
stoichiometry: 1.0
species: 451665

451665
type: Species
is version of: C00562
in compartment: 451619
initial concentration: 0.0
constant: false
boundary condition: false
is: SBO:0000252
initial amount: NaN
is version of: Q63844
has part: MOD:00048
has only substance units: false

775359
type: SpeciesReference
stoichiometry: 1.0
species: 451655

451655
type: Species
is version of: Q63844
has part: MOD:00048
is version of: C00562
has only substance units: false
constant: false
initial concentration: 0.0
in compartment: 451619
boundary condition: false
has property: GO:0004707
is: SBO:0000252
initial amount: NaN
has part: MOD:00047

451837
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 53.0816

451704
type: Reaction
kinetic law: 774392
product: 774380
reactant: 774367
is: SBO:0000397
fast: false
reversible: false

774380
type: SpeciesReference
stoichiometry: 1.0
species: 451679

451679
type: Species
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

774367
type: SpeciesReference
stoichiometry: 1.0
species: 451677

451693
type: Reaction
kinetic law: 774208
product: 774196
reactant: 774184
is: SBO:0000397
fast: false
reversible: false

774196
type: SpeciesReference
stoichiometry: 1.0
species: 451669

774184
type: SpeciesReference
stoichiometry: 1.0
species: 451642

451642
type: Species
boundary condition: false
has property: GO:0019897
initial concentration: 0.0
initial amount: NaN
has only substance units: false
is version of: P29351
in compartment: 451619
is: SBO:0000252
constant: false

451740
type: Reaction
kinetic law: 775106
product: 775094
reactant: 775082
is version of: GO:0006470
is: SBO:0000330
fast: false
reversible: false

775094
type: SpeciesReference
stoichiometry: 1.0
species: 451630

451630
type: Species
is version of: Q63932
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 11.0
initial amount: NaN
in compartment: 451619

775082
type: SpeciesReference
stoichiometry: 1.0
species: 451661

451683
type: Species
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

291524
type: Parameter
is: SBO:0000381
constant: true
units: 773919
value: 40.5364
name: scale_ppMEK

451821
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 215.158

451626
type: Species
has version: Q62245
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5101
initial amount: NaN
in compartment: 451619

451722
type: Reaction
is: SBO:0000216
product: 774744
kinetic law: 774768
modifier: 774756
is version of: GO:0000185
is version of: GO:0006468
fast: false
reversible: false
reactant: 774732

774744
type: SpeciesReference
stoichiometry: 1.0
species: 451649

451647
type: Species
in compartment: 451619
is: SBO:0000252
constant: false
initial amount: NaN
has property: GO:0005085
initial concentration: 0.0
has property: GO:0019897
has only substance units: false
is version of: Q62245
boundary condition: false

774732
type: SpeciesReference
stoichiometry: 1.0
species: 451628

451657
type: Species
has only substance units: false
has property: GO:0004707
is: SBO:0000252
is version of: P63085
has part: MOD:00047
boundary condition: false
initial amount: NaN
is version of: C00562
has part: MOD:00048
in compartment: 451619
constant: false
initial concentration: 0.0

451843
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 5122.68

291530
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppMEK1

451685
type: Species
in compartment: 451619
constant: false
is version of: P07321
has only substance units: false
initial concentration: 50.0
substance units: 773786
is: SBO:0000252
boundary condition: false
initial amount: NaN
has property: GO:0005128

773786
type: SBMLUnitsDef
unit: 773798
name: U

773798
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

451754
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.12.2
is version of: GO:0000187
reactant: 775396
modifier: 775420
is: SBO:0000216
reversible: false
kinetic law: 775432
fast: false
product: 775408
is version of: GO:0004708

775396
type: SpeciesReference
stoichiometry: 1.0
species: 451667

775408
type: SpeciesReference
stoichiometry: 1.0
species: 451657

451681
type: Species
has version: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

291539
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppERK2

451742
type: Reaction
kinetic law: 775143
product: 775131
reactant: 775119
is version of: GO:0006470
is: SBO:0000330
fast: false
reversible: false

775131
type: SpeciesReference
stoichiometry: 1.0
species: 451632

451632
type: Species
is version of: P31938
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 24.0
initial amount: NaN
in compartment: 451619

775119
type: SpeciesReference
stoichiometry: 1.0
species: 451663

451663
type: Species
initial amount: NaN
is version of: C00562
boundary condition: false
is: SBO:0000252
has only substance units: false
is version of: P31938
in compartment: 451619
constant: false
initial concentration: 0.0

451624
type: Species
is version of: P29351
in compartment: 451619
is version of: IPR000387
constant: false
boundary condition: false
initial concentration: 10.7991
is: SBO:0000252
has only substance units: false
initial amount: NaN

451728
type: Reaction
is: SBO:0000216
is version of: GO:0004709
reversible: false
modifier: 774889
is part of: REACT 545.5
is version of: http://identifiers.org/ec-code/2.7.11.25
product: 774877
fast: false
reactant: 774865
kinetic law: 774901

774877
type: SpeciesReference
stoichiometry: 1.0
species: 451663

774865
type: SpeciesReference
stoichiometry: 1.0
species: 451632

451689
type: Reaction
modifier: 774112
fast: false
is version of: GO:0004715
product: 774100
reactant: 774088
reversible: false
kinetic law: 774124
is: SBO:0000216
is version of: http://identifiers.org/ec-code/2.7.10.2

774100
type: SpeciesReference
stoichiometry: 1.0
species: 451640

774088
type: SpeciesReference
stoichiometry: 1.0
species: 451622

451686
type: Reaction
is version of: GO:0010535
kinetic law: 774076
is homolog to: REACT 23935.1
is version of: http://identifiers.org/ec-code/2.7.10.2
modifier: 774064
is: SBO:0000216
product: 774052
reversible: false
reactant: 774040
fast: false
is version of: GO:0004715

774052
type: SpeciesReference
stoichiometry: 1.0
species: 451638

774040
type: SpeciesReference
stoichiometry: 1.0
species: 451620

451823
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 0.687193

451764
type: Reaction
is version of: GO:0017017
reactant: 775612
is part of: REACT 12439.1
reversible: false
is: SBO:0000216
is version of: GO:0006470
fast: false
kinetic law: 775636
product: 775624

775612
type: SpeciesReference
stoichiometry: 1.0
species: 451665

775624
type: SpeciesReference
stoichiometry: 1.0
species: 451634

773712
type: SBMLUnitsDef
unit: 773724
name: 10E4 molecules

773724
type: SBMLUnit
exponent: 1.0
scale: 4
multipler: 1.0
kind: ITEM

451756
type: Reaction
kinetic law: 775480
is: SBO:0000216
is version of: GO:0004708
product: 775456
reversible: false
reactant: 775444
fast: false
modifier: 775468
is part of: REACT 136.4
is version of: http://identifiers.org/ec-code/2.7.12.2
is version of: GO:0000187

775456
type: SpeciesReference
stoichiometry: 1.0
species: 451655

775444
type: SpeciesReference
stoichiometry: 1.0
species: 451665

451697
type: Reaction
kinetic law: 774282
product: 774269
reactant: 774257
is: SBO:0000397
fast: false
reversible: false

774269
type: SpeciesReference
stoichiometry: 1.0
species: 451673

451673
type: Species
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619

774257
type: SpeciesReference
stoichiometry: 1.0
species: 451671

451744
type: Reaction
modifier: 775179
reactant: 775155
kinetic law: 775191
is version of: GO:0004708
reversible: false
fast: false
is part of: REACT 136.4
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 775167
is: SBO:0000216

775155
type: SpeciesReference
stoichiometry: 1.0
species: 451634

775167
type: SpeciesReference
stoichiometry: 1.0
species: 451665

451691
type: Reaction
reversible: false
is version of: GO:0006461
reactant: 774136
fast: false
modifier: 774160
product: 774148
is: SBO:0000177
is version of: GO:0051668
kinetic law: 774172

774136
type: SpeciesReference
stoichiometry: 1.0
species: 451624

774148
type: SpeciesReference
stoichiometry: 1.0
species: 451642

451772
type: Reaction
kinetic law: 775804
product: 775792
reactant: 775780
is version of: GO:0006470
is: SBO:0000330
fast: false
reversible: false

775792
type: SpeciesReference
stoichiometry: 1.0
species: 451626

775780
type: SpeciesReference
stoichiometry: 1.0
species: 451659

451817
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 0.374228

291551
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_mSOS

451841
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 3.00453

451738
type: Reaction
reactant: 775046
is version of: GO:0051389
reversible: false
is version of: GO:0006470
kinetic law: 775070
is: SBO:0000330
fast: false
product: 775058

775046
type: SpeciesReference
stoichiometry: 1.0
species: 451653

775058
type: SpeciesReference
stoichiometry: 1.0
species: 451663

451760
type: Reaction
reversible: false
is part of: REACT 12439.1
is: SBO:0000216
product: 775552
is version of: GO:0000188
kinetic law: 775564
is version of: GO:0017017
is version of: GO:0006470
reactant: 775540
fast: false

775552
type: SpeciesReference
stoichiometry: 1.0
species: 451665

775540
type: SpeciesReference
stoichiometry: 1.0
species: 451655

291536
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppERK1

451805
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 0.0248773

451825
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 667.957

451839
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 39.0886

451726
type: Reaction
kinetic law: 774852
is version of: GO:0004709
is: SBO:0000216
reversible: false
modifier: 774840
product: 774828
reactant: 774816
is version of: http://identifiers.org/ec-code/2.7.11.25
is part of: REACT 1727.5
fast: false

774828
type: SpeciesReference
stoichiometry: 1.0
species: 451661

774816
type: SpeciesReference
stoichiometry: 1.0
species: 451630

W3 CDTF: Wed Oct 27 17:50:24 BST 2010

451762
type: Reaction
reversible: false
is part of: REACT 12439.1
is version of: GO:0006470
kinetic law: 775600
is: SBO:0000216
product: 775588
fast: false
reactant: 775576
is version of: GO:0000188
is version of: GO:0017017

775588
type: SpeciesReference
stoichiometry: 1.0
species: 451667

775576
type: SpeciesReference
stoichiometry: 1.0
species: 451657

451733
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.25
is version of: GO:0000186
product: 774974
reactant: 774962
kinetic law: 774998
fast: false
reversible: false
is part of: REACT 545.5
modifier: 774986
is: SBO:0000216

774974
type: SpeciesReference
stoichiometry: 1.0
species: 451653

774962
type: SpeciesReference
stoichiometry: 1.0
species: 451663

451710
type: Reaction
kinetic law: 774501
product: 774489
reactant: 774477
is: SBO:0000396
fast: false
reversible: false

774489
type: SpeciesReference
stoichiometry: 1.0
species: 451645

774477
type: SpeciesReference
stoichiometry: 1.0
species: 451683

291527
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_pEpoR

451831
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 2.4927

451770
type: Reaction
product: 775744
is: GO:0004707
is version of: http://identifiers.org/ec-code/2.7.11.24
fast: false
is: SBO:0000216
kinetic law: 775768
reactant: 775732
is homolog to: REACT 1420.5
is version of: GO:0006468
reversible: false
modifier: 775756

775744
type: SpeciesReference
stoichiometry: 1.0
species: 451659

775732
type: SpeciesReference
stoichiometry: 1.0
species: 451647

451758
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.12.2
is version of: GO:0000187
fast: false
product: 775504
is version of: GO:0004708
modifier: 775516
reversible: false
reactant: 775492
is: SBO:0000216
kinetic law: 775528

775504
type: SpeciesReference
stoichiometry: 1.0
species: 451657

775492
type: SpeciesReference
stoichiometry: 1.0
species: 451667

451815
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 0.144515

291515
type: Parameter
is: SBO:0000381
constant: true
units: 773919
value: 0.21008
name: scale_pJAK2

ORG:
  orgname: German Cancer Research Center
n:
  given: Marcel
  family: Schilling

291545
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_pSOS

451746
type: Reaction
modifier: 775227
kinetic law: 775239
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 775215
fast: false
is version of: GO:0004708
is: SBO:0000216
reversible: false
reactant: 775203

775215
type: SpeciesReference
stoichiometry: 1.0
species: 451667

775203
type: SpeciesReference
stoichiometry: 1.0
species: 451636

451720
type: Reaction
kinetic law: 774720
product: 774707
reactant: 774695
is: SBO:0000180
fast: false
reversible: false

774707
type: SpeciesReference
stoichiometry: 1.0
species: 451626

774695
type: SpeciesReference
stoichiometry: 1.0
species: 451647

451809
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 0.368384

451803
type: Parameter
is: SBO:0000035
constant: true
units: 773968
value: 0.408408

451708
type: Reaction
kinetic law: 774464
product: 774452
reactant: 774440
is: SBO:0000397
fast: false
reversible: false

774452
type: SpeciesReference
stoichiometry: 1.0
species: 451683

774440
type: SpeciesReference
stoichiometry: 1.0
species: 451681

291521
type: Parameter
is: SBO:0000381
constant: true
units: 773919
value: 1.10228
name: scale_SOS

451712
type: Reaction
kinetic law: 774537
product: 774525
reactant: 774513
is: SBO:0000396
fast: false
reversible: false

774525
type: SpeciesReference
stoichiometry: 1.0
species: 451624

774513
type: SpeciesReference
stoichiometry: 1.0
species: 451645

291533
type: Parameter
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppMEK2

451718
type: Reaction
is version of: GO:0006461
reactant: 774646
kinetic law: 774683
fast: false
is: SBO:0000177
reversible: false
modifier: 774670
product: 774658

774646
type: SpeciesReference
stoichiometry: 1.0
species: 451626

774658
type: SpeciesReference
stoichiometry: 1.0
species: 451647

451768
type: Reaction
fast: false
is version of: GO:0006468
kinetic law: 775720
is version of: http://identifiers.org/ec-code/2.7.11.24
modifier: 775708
is: GO:0004707
reactant: 775684
is: SBO:0000216
product: 775696
reversible: false
is homolog to: REACT 1420.5

775684
type: SpeciesReference
stoichiometry: 1.0
species: 451647

775696
type: SpeciesReference
stoichiometry: 1.0
species: 451659

451833
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 59.5251

451700
type: Reaction
kinetic law: 774319
product: 774307
reactant: 774295
is: SBO:0000397
fast: false
reversible: false

774307
type: SpeciesReference
stoichiometry: 1.0
species: 451675

774295
type: SpeciesReference
stoichiometry: 1.0
species: 451673

451706
type: Reaction
kinetic law: 774428
product: 774416
reactant: 774404
is: SBO:0000397
fast: false
reversible: false

774416
type: SpeciesReference
stoichiometry: 1.0
species: 451681

774404
type: SpeciesReference
stoichiometry: 1.0
species: 451679

451748
type: Reaction
is: SBO:0000216
modifier: 775275
reversible: false
is part of: REACT 136.4
product: 775263
is version of: GO:0004708
fast: false
is version of: http://identifiers.org/ec-code/2.7.12.2
kinetic law: 775287
reactant: 775251

775263
type: SpeciesReference
stoichiometry: 1.0
species: 451665

775251
type: SpeciesReference
stoichiometry: 1.0
species: 451634

451819
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 3.11919

451730
type: Reaction
reactant: 774913
kinetic law: 774949
is part of: REACT 1727.5
modifier: 774937
is version of: GO:0000186
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.25
product: 774925
is: SBO:0000216
fast: false

774913
type: SpeciesReference
stoichiometry: 1.0
species: 451661

774925
type: SpeciesReference
stoichiometry: 1.0
species: 451651

291512
type: Parameter
is: SBO:0000381
constant: true
units: 773919
value: 0.493312
name: scale_pEpoR

451807
type: Parameter
is: SBO:0000036
constant: true
units: 773992
value: 1.19995

773811
type: SBMLUnitsDef
unit: 773834
unit: 773822
name: U_per_ml

773834
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE

773822
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

W3 CDTF: Fri Oct 29 12:55:02 BST 2010

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler