BIOMD0000000256
type: SBMLModel
reaction: 801420
species: 801333
area units: metaid_0000005
units def: 462238
name: Rehm2006_Caspase
reaction: 801409
reaction: 801400
reaction: 801375
parameter: 801645
parameter: 801503
parameter: 801541
reaction: 801417
compartment: 801296
rule: 801469
reaction: 801363
species: 801322
reaction: 801405
parameter: 801579
reaction: 801388
parameter: 801594
rule: 801485
parameter: 801606
parameter: 801621
species: 801327
parameter: 801614
parameter: 801526
occurs in: BTO:0000567
parameter: 801567
parameter: 801499
reaction: 801376
rule: 801480
rule: 801466
parameter: 801632
reaction: 801348
parameter: 801640
parameter: 801649
species: 801336
parameter: 801514
parameter: 801602
species: 801318
parameter: 801494
parameter: 801509
rule: 801478
reaction: 801364
parameter: 801570
parameter: 801512
reaction: 801352
parameter: 801505
reaction: 801419
species: 801328
parameter: 801648
parameter: 801493
species: 801312
rule: 801472
parameter: 801500
reaction: 801340
parameter: 801588
parameter: 801596
parameter: 801511
parameter: 801646
parameter: 801558
parameter: 801599
parameter: 801528
parameter: 801576
parameter: 801591
parameter: 801569
reaction: 801378
reaction: 801395
parameter: 801634
reaction: 801406
parameter: 801642
parameter: 801539
parameter: 801587
parameter: 801554
reaction: 801358
parameter: 801516
parameter: 801564
rule: 801471
reaction: 801366

801420
type: Reaction
has version: REACT 89
reactant: 464833
kinetic law: 464869
is version of: GO:0006461
product: 464857
fast: false
reversible: true
is: SBO:0000526
reactant: 464845

464833
type: SpeciesReference
stoichiometry: 1.0
species: 801303

801303
type: Species
is version of: P55211
name: ProCasp9
in compartment: 801296
boundary condition: false
has only substance units: false
is: SBO:0000245
initial concentration: 0.03
initial amount: NaN
constant: false

801296
type: Compartment
is: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0

464857
type: SpeciesReference
stoichiometry: 1.0
species: 801301

801301
type: Species
is version of: P55211
in compartment: 801296
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000245
initial concentration: 0.0
name: Casp9(p35-p12)
initial amount: NaN

464845
type: SpeciesReference
stoichiometry: 1.0
species: 801328

801328
type: Species
is version of: O14727
is: SBO:0000245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.372
initial amount: NaN
in compartment: 801296

801333
type: Species
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 801296
name: Clevage Products

462238
type: SBMLUnitsDef
unit: 462251
name: 1/min

462251
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

801409
type: Reaction
kinetic law: 464627
reactant: 464615
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464615
type: SpeciesReference
stoichiometry: 1.0
species: 801325

801325
type: Species
has only substance units: false
is part of: P98170
is: SBO:0000296
constant: false
initial concentration: 0.0
initial amount: NaN
name: BIR3R-SMAC
in compartment: 801296
boundary condition: false
has part: Q9NR28

801400
type: Reaction
kinetic law: 464481
reactant: 464469
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464469
type: SpeciesReference
stoichiometry: 1.0
species: 801313

801313
type: Species
initial amount: NaN
name: XIAP-p2frag-Casp3
is: SBO:0000296
constant: false
is part of: P55211
has only substance units: false
boundary condition: false
initial concentration: 0.0
has part: P98170
has part: P42574
in compartment: 801296

801375
type: Reaction
reversible: true
kinetic law: 463823
fast: false
reactant: 463799
is: SBO:0000526
is version of: GO:0006461
product: 463811
reactant: 463787

463799
type: SpeciesReference
stoichiometry: 2.0
species: 801327

801327
type: Species
is version of: Q9NR28
is: SBO:0000245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 801296

463811
type: SpeciesReference
stoichiometry: 1.0
species: 801322

801322
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 0.0
boundary condition: false
in compartment: 801296
constant: false
has part: P98170
name: XIAP-2*SMAC
is: SBO:0000296

463787
type: SpeciesReference
stoichiometry: 1.0
species: 801300

801300
type: Species
is version of: P98170
is: SBO:0000245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.063
initial amount: NaN
in compartment: 801296

801645
type: Parameter
constant: false
units: dimensionless
value: NaN

801503
type: Parameter
constant: true
units: 462141
value: 2.4

462141
type: SBMLUnitsDef
unit: 462178
unit: 462166
unit: 462154
name: 1/(uM*min)

462178
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

462166
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

462154
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

801541
type: Parameter
constant: true
units: 462238
value: 0.144

801417
type: Reaction
is version of: GO:0032403
is: SBO:0000344
product: 464760
product: 464773
kinetic law: 464785
fast: false
reversible: true
reactant: 464748
reactant: 464736

464760
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801304
type: Species
is version of: P42574
is: SBO:0000245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 801296

464773
type: SpeciesReference
stoichiometry: 1.0
species: 801333

464748
type: SpeciesReference
stoichiometry: 1.0
species: 801331

801331
type: Species
constant: false
boundary condition: false
has only substance units: false
is part of: P42574
initial concentration: 1.0
is: SBO:0000252
initial amount: NaN
name: Casp3 Substrate
in compartment: 801296

464736
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801363
type: Reaction
is: SBO:0000344
product: 463376
reactant: 463364
reversible: true
product: 463389
fast: false
reactant: 463352
is version of: GO:0032403
product: 463401
kinetic law: 463413

463376
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463364
type: SpeciesReference
stoichiometry: 1.0
species: 801310

801310
type: Species
initial concentration: 0.0
is: SBO:0000296
has part: P42574
name: XIAP-Casp9-Casp3
has part: P55211
in compartment: 801296
boundary condition: false
constant: false
has part: P98170
has only substance units: false
initial amount: NaN

463389
type: SpeciesReference
stoichiometry: 1.0
species: 801306

801306
type: Species
constant: false
initial concentration: 0.0
initial amount: NaN
has part: P55211
boundary condition: false
name: Casp9(p35-p10)
in compartment: 801296
is: SBO:0000245
has only substance units: false

463352
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463401
type: SpeciesReference
stoichiometry: 1.0
species: 801313

801405
type: Reaction
kinetic law: 464555
reactant: 464543
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464543
type: SpeciesReference
stoichiometry: 1.0
species: 801315

801315
type: Species
is part of: P98170
is: SBO:0000245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 801296

801579
type: Parameter
constant: false
units: 462238
value: 0.0347

801388
type: Reaction
kinetic law: 464310
reactant: 464298
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464298
type: SpeciesReference
stoichiometry: 1.0
species: 801306

801594
type: Parameter
constant: true
units: 462238
value: 0.0058

801606
type: Parameter
constant: false
units: 462056
value: NaN
name: limiting factor for apoptosome formation

462056
type: SBMLUnitsDef
unit: 462081
unit: 462068
name: microM

462081
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

462068
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

801621
type: Parameter
constant: false
units: dimensionless
value: NaN
name: normalised Casp-3

801614
type: Parameter
constant: false
units: dimensionless
value: NaN
name: XIAP2*SMAC per XIAP

801526
type: Parameter
constant: true
units: 462141
value: 12.0

801567
type: Parameter
constant: true
units: 462141
value: 156.0

801499
type: Parameter
constant: true
units: 462141
value: 6.0

801376
type: Reaction
is version of: GO:0032403
product: 463872
reactant: 463847
kinetic law: 463884
reversible: true
reactant: 463835
is: SBO:0000526
product: 463860
is version of: REACT 1312
fast: false

463872
type: SpeciesReference
stoichiometry: 1.0
species: 801301

463847
type: SpeciesReference
stoichiometry: 2.0
species: 801327

463835
type: SpeciesReference
stoichiometry: 1.0
species: 801309

801309
type: Species
constant: false
name: XIAP-Casp9
has only substance units: false
has part: P98170
initial concentration: 0.0
is: SBO:0000296
initial amount: NaN
boundary condition: false
in compartment: 801296
has part: P55211

463860
type: SpeciesReference
stoichiometry: 1.0
species: 801322

801632
type: Parameter
constant: false
units: dimensionless
value: NaN

801348
type: Reaction
is: SBO:0000526
reversible: true
product: 462686
fast: false
kinetic law: 462698
reactant: 462662
is version of: GO:0006461
reactant: 462674

462686
type: SpeciesReference
stoichiometry: 1.0
species: 801310

462662
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462674
type: SpeciesReference
stoichiometry: 1.0
species: 801309

801640
type: Parameter
constant: false
units: dimensionless
value: NaN

801649
type: Parameter
constant: false
units: 462056
value: NaN

801336
type: Species
initial concentration: 10.0
is: SBO:0000245
has only substance units: false
boundary condition: false
is version of: P08574
constant: false
name: Cytochrome C in mitochondrium
in compartment: 801298
initial amount: NaN

801298
type: Compartment
is version of: GO:0005739
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: mitochondrium

801514
type: Parameter
constant: true
units: 462141
value: 156.0

801602
type: Parameter
constant: true
units: 462238
value: 0.0058

801318
type: Species
is part of: P98170
is: SBO:0000245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 801296

801494
type: Parameter
constant: false
units: 462238
value: 0.0039

801509
type: Parameter
constant: true
units: 462238
value: 0.144

801364
type: Reaction
product: 463461
is version of: GO:0032403
is: SBO:0000344
reactant: 463425
fast: false
reversible: true
kinetic law: 463486
reactant: 463437
product: 463449
product: 463473

463461
type: SpeciesReference
stoichiometry: 1.0
species: 801306

463425
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463437
type: SpeciesReference
stoichiometry: 1.0
species: 801309

463449
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463473
type: SpeciesReference
stoichiometry: 1.0
species: 801312

801312
type: Species
name: XIAP-p2 fragment
boundary condition: false
has part: P98170
initial amount: NaN
initial concentration: 0.0
is: SBO:0000296
constant: false
is part of: P55211
has only substance units: false
in compartment: 801296

801570
type: Parameter
constant: true
units: 462141
value: 156.0

801512
type: Parameter
constant: true
units: 462238
value: 0.144

801352
type: Reaction
product: 462832
fast: false
reactant: 462806
is: SBO:0000526
is version of: GO:0032403
kinetic law: 462872
product: 462845
reversible: true
product: 462859
reactant: 462819

462832
type: SpeciesReference
stoichiometry: 1.0
species: 801315

462806
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462845
type: SpeciesReference
stoichiometry: 1.0
species: 801318

462859
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462819
type: SpeciesReference
stoichiometry: 1.0
species: 801300

801505
type: Parameter
constant: true
units: 462141
value: 156.0

801419
type: Reaction
kinetic law: 464821
product: 464809
reactant: 464797
is version of: REACT 1101
is: SBO:0000185
fast: false
reversible: true

464809
type: SpeciesReference
stoichiometry: 1.0
species: 801327

464797
type: SpeciesReference
stoichiometry: 1.0
species: 801334

801334
type: Species
name: SMAC in mitochondrium
is version of: Q9NR28
initial concentration: 0.126
in compartment: 801298
has only substance units: false
is: SBO:0000245
constant: false
initial amount: NaN
boundary condition: false

801648
type: Parameter
constant: false
units: 462056
value: NaN

801493
type: Parameter
constant: false
units: 462093
value: 4.68E-4

462093
type: SBMLUnitsDef
unit: 462129
unit: 462117
unit: 462105
name: uM/min

462129
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

462117
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

462105
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

801500
type: Parameter
constant: true
units: 462141
value: 12.0

801340
type: Reaction
product: 462419
kinetic law: 462431
fast: false
reactant: 462383
product: 462407
is: SBO:0000297
is version of: GO:0016485
reversible: true
reactant: 462395

462419
type: SpeciesReference
stoichiometry: 1.0
species: 801301

462383
type: SpeciesReference
stoichiometry: 1.0
species: 801301

462407
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462395
type: SpeciesReference
stoichiometry: 1.0
species: 801299

801299
type: Species
initial concentration: 0.12
boundary condition: false
name: ProCasp3
in compartment: 801296
is version of: P42574
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000245

801588
type: Parameter
constant: false
units: 462238
value: 0.0347

801596
type: Parameter
constant: false
units: 462238
value: 0.0347

801511
type: Parameter
constant: true
units: 462141
value: 156.0

801646
type: Parameter
constant: true
units: 462056
value: 0.01

801558
type: Parameter
constant: true
units: 462190
value: 156.0

462190
type: SBMLUnitsDef
unit: 462226
unit: 462214
unit: 462202
name: 1/(uM^2*min)

462226
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

462214
type: SBMLUnit
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE

462202
type: SBMLUnit
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE

801599
type: Parameter
constant: false
units: 462238
value: 0.0058

801528
type: Parameter
constant: true
units: 462141
value: 12.0

801576
type: Parameter
constant: true
units: 462238
value: 0.0058

801591
type: Parameter
constant: true
units: 462238
value: 0.0058

801569
type: Parameter
constant: true
units: 462141
value: 0.33

801378
type: Reaction
is version of: REACT 1090
is: SBO:0000526
reactant: 463908
fast: false
reactant: 463896
kinetic law: 463945
product: 463920
is version of: GO:0032403
product: 463933
reversible: true

463908
type: SpeciesReference
stoichiometry: 2.0
species: 801327

463896
type: SpeciesReference
stoichiometry: 1.0
species: 801307

801307
type: Species
initial concentration: 0.0
is: SBO:0000296
constant: false
has part: P42574
has only substance units: false
boundary condition: false
initial amount: NaN
name: XIAP-Casp3
in compartment: 801296
has part: P98170

463920
type: SpeciesReference
stoichiometry: 1.0
species: 801322

463933
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801395
type: Reaction
kinetic law: 464407
reactant: 464395
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464395
type: SpeciesReference
stoichiometry: 1.0
species: 801310

801634
type: Parameter
constant: false
units: dimensionless
value: NaN

801406
type: Reaction
kinetic law: 464579
reactant: 464567
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464567
type: SpeciesReference
stoichiometry: 1.0
species: 801318

801642
type: Parameter
constant: false
units: dimensionless
value: NaN

801539
type: Parameter
constant: true
units: 462141
value: 156.0

801587
type: Parameter
constant: true
units: 462238
value: 0.0347

801554
type: Parameter
constant: true
units: 462141
value: 156.0

801358
type: Reaction
product: 463174
is: SBO:0000344
is version of: GO:0032403
kinetic law: 463187
product: 463161
product: 463148
reversible: true
fast: false
reactant: 463135
reactant: 463122

463174
type: SpeciesReference
stoichiometry: 1.0
species: 801321

801321
type: Species
name: BIR3R-p2frag
initial concentration: 0.0
has only substance units: false
in compartment: 801296
is: SBO:0000296
boundary condition: false
is part of: P55211
is part of: P98170
initial amount: NaN
constant: false

463161
type: SpeciesReference
stoichiometry: 1.0
species: 801316

801316
type: Species
boundary condition: false
in compartment: 801296
has only substance units: false
name: BIR12-Casp3
initial concentration: 0.0
is: SBO:0000296
constant: false
has part: P42574
initial amount: NaN
is part of: P98170

463148
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463135
type: SpeciesReference
stoichiometry: 1.0
species: 801313

463122
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801516
type: Parameter
constant: true
units: 462238
value: 0.144

801564
type: Parameter
constant: true
units: 462238
value: 14.2

801366
type: Reaction
kinetic law: 463558
product: 463534
is: SBO:0000344
reactant: 463510
product: 463522
is version of: GO:0032403
fast: false
reactant: 463498
product: 463546
reversible: true

463534
type: SpeciesReference
stoichiometry: 1.0
species: 801321

463510
type: SpeciesReference
stoichiometry: 1.0
species: 801319

801319
type: Species
has part: P55211
is part of: P98170
is: SBO:0000296
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
in compartment: 801296
initial concentration: 0.0
name: BIR3R-Casp9

463522
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463498
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463546
type: SpeciesReference
stoichiometry: 1.0
species: 801306

801572
type: Parameter
constant: true
units: 462190
value: 420.0

462008
type: SBMLUnitsDef
unit: 462020
name: min

462020
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

801519
type: Parameter
constant: true
units: 462141
value: 12.0

801534
type: Parameter
constant: true
units: 462238
value: 0.144

801391
type: Reaction
kinetic law: 464359
reactant: 464347
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464347
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801369
type: Reaction
is version of: GO:0006461
kinetic law: 463654
reactant: 463618
product: 463642
fast: false
reactant: 463630
reversible: true
is: SBO:0000344

463618
type: SpeciesReference
stoichiometry: 1.0
species: 801301

463642
type: SpeciesReference
stoichiometry: 1.0
species: 801310

463630
type: SpeciesReference
stoichiometry: 1.0
species: 801307

801575
type: Parameter
constant: true
units: 462238
value: 0.0058

801542
type: Parameter
constant: true
value: 0.0

801590
type: Parameter
constant: false
units: 462238
value: 0.0347

801583
type: Parameter
constant: false
units: 462238
value: 0.0347

801346
type: Reaction
reversible: true
kinetic law: 462650
fast: false
reactant: 462625
is: SBO:0000526
product: 462638
is version of: GO:0006461
reactant: 462612

462625
type: SpeciesReference
stoichiometry: 1.0
species: 801300

462638
type: SpeciesReference
stoichiometry: 1.0
species: 801307

462612
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801354
type: Reaction
is: SBO:0000344
product: 462937
product: 462924
fast: false
kinetic law: 462950
product: 462911
reactant: 462898
is version of: GO:0032403
reactant: 462885
reversible: true

462937
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462924
type: SpeciesReference
stoichiometry: 1.0
species: 801319

462911
type: SpeciesReference
stoichiometry: 1.0
species: 801315

462898
type: SpeciesReference
stoichiometry: 1.0
species: 801309

462885
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801560
type: Parameter
constant: true
units: 462141
value: 4.45

801349
type: Reaction
reversible: true
reactant: 462722
is: SBO:0000526
reactant: 462710
fast: false
is version of: GO:0006461
product: 462734
kinetic law: 462746

462722
type: SpeciesReference
stoichiometry: 1.0
species: 801312

462710
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462734
type: SpeciesReference
stoichiometry: 1.0
species: 801313

801619
type: Parameter
constant: false
units: dimensionless
value: NaN
name: normalised Casp9-P

801522
type: Parameter
constant: true
units: 462141
value: 12.0

801357
type: Reaction
fast: false
product: 463095
kinetic law: 463108
is: SBO:0000344
reversible: true
product: 463069
is version of: GO:0032403
product: 463082
reactant: 463043
reactant: 463056

463095
type: SpeciesReference
stoichiometry: 1.0
species: 801321

463069
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463082
type: SpeciesReference
stoichiometry: 1.0
species: 801315

463043
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463056
type: SpeciesReference
stoichiometry: 1.0
species: 801312

801563
type: Parameter
constant: true
units: 462141
value: 0.33

801342
type: Reaction
fast: false
reactant: 462456
is: SBO:0000231
kinetic law: 462492
reversible: true
product: 462480
is version of: GO:0016485
product: 462468
reactant: 462444

462456
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462480
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462468
type: SpeciesReference
stoichiometry: 1.0
species: 801306

462444
type: SpeciesReference
stoichiometry: 1.0
species: 801301

801330
type: Species
has part: Q9NR28
name: XIAP-p2frag-2*SMAC
constant: false
has only substance units: false
initial concentration: 0.0
in compartment: 801296
is part of: P55211
is: SBO:0000296
boundary condition: false
initial amount: NaN
has part: P98170

801629
type: Parameter
constant: false
units: 462056
value: NaN
name: total SMAC

801623
type: Parameter
constant: false
units: 462056
value: NaN
name: Caspase3 tot

801617
type: Parameter
constant: false
units: 462056
value: NaN
name: Caspase9 tot

801612
type: Parameter
constant: false
units: 462056
value: NaN
name: initial XIAP conc

801345
type: Reaction
fast: false
kinetic law: 462600
is: SBO:0000344
is version of: GO:0016485
reversible: true
reactant: 462564
product: 462588
reactant: 462576

462564
type: SpeciesReference
stoichiometry: 1.0
species: 801299

462588
type: SpeciesReference
stoichiometry: 2.0
species: 801304

462576
type: SpeciesReference
stoichiometry: 1.0
species: 801304

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

801324
type: Species
has part: Q9NR28
is: SBO:0000296
constant: false
initial amount: NaN
is part of: P98170
initial concentration: 0.0
in compartment: 801296
name: BIR12-SMAC
has only substance units: false
boundary condition: false

801463
type: Event
event assignment: 464966
event assignment: 464942
event assignment: 465028
event assignment: 465015
event assignment: 465064
event assignment: 465052
event assignment: 464930
event assignment: 465003
event assignment: 464979
event assignment: 464954
event assignment: 464991
event assignment: 465076
event assignment: 465040
use values from trigger time: true
trigger: 464918

801593
type: Parameter
constant: false
units: 462238
value: 0.0347

801581
type: Parameter
constant: false
units: 462238
value: 0.0347

801496
type: Parameter
constant: false
units: 462093
value: 7.308E-4

801600
type: Parameter
constant: false
units: 462238
value: 0.0347

801497
type: Parameter
constant: false
units: 462238
value: 0.0116

464918
type: Trigger
persistant: true
initial value: true

801548
type: Parameter
constant: true
units: 462190
value: 420.0

801408
type: Reaction
kinetic law: 464603
reactant: 464591
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464591
type: SpeciesReference
stoichiometry: 1.0
species: 801324

801556
type: Parameter
constant: true
units: 462190
value: 420.0

801597
type: Parameter
constant: true
units: 462238
value: 0.0058

801393
type: Reaction
kinetic law: 464383
reactant: 464371
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464371
type: SpeciesReference
stoichiometry: 1.0
species: 801307

801529
type: Parameter
constant: true
units: 462141
value: 12.0

801544
type: Parameter
constant: true
value: 0.0

801379
type: Reaction
is version of: GO:0032403
product: 463982
reactant: 463957
is: SBO:0000526
kinetic law: 464018
product: 463994
reactant: 463969
fast: false
reversible: true
product: 464006

463982
type: SpeciesReference
stoichiometry: 1.0
species: 801322

463957
type: SpeciesReference
stoichiometry: 1.0
species: 801310

463994
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463969
type: SpeciesReference
stoichiometry: 2.0
species: 801327

464006
type: SpeciesReference
stoichiometry: 1.0
species: 801301

801585
type: Parameter
constant: true
units: 462238
value: 0.0058

801547
type: Parameter
constant: true
units: 462238
value: 0.133

801373
type: Reaction
kinetic law: 463775
product: 463763
reactant: 463751
is version of: GO:0043241
is: SBO:0000180
fast: false
reversible: true

463763
type: SpeciesReference
stoichiometry: 1.0
species: 801300

463751
type: SpeciesReference
stoichiometry: 1.0
species: 801312

801381
type: Reaction
reversible: true
is version of: GO:0006461
product: 464055
fast: false
reactant: 464043
reactant: 464031
is: SBO:0000526
kinetic law: 464067

464055
type: SpeciesReference
stoichiometry: 1.0
species: 801324

464043
type: SpeciesReference
stoichiometry: 1.0
species: 801327

464031
type: SpeciesReference
stoichiometry: 1.0
species: 801315

801517
type: Parameter
constant: true
units: 462141
value: 12.0

801338
type: Reaction
kinetic law: 462347
product: 462335
is: SBO:0000393
fast: false
reversible: true
name: ProCaspase3 Production

462335
type: SpeciesReference
stoichiometry: 1.0
species: 801299

801532
type: Parameter
constant: true
units: 462141
value: 156.0

801337
type: Species
is: SBO:0000245
has only substance units: false
initial concentration: 0.0
in compartment: 801296
constant: false
initial amount: NaN
boundary condition: false
is version of: P08574
name: cytosolic Cytochrome C

801367
type: Reaction
is version of: GO:0006461
reactant: 463570
reactant: 463582
fast: false
reversible: true
kinetic law: 463606
is: SBO:0000344
product: 463594

463570
type: SpeciesReference
stoichiometry: 1.0
species: 801301

463582
type: SpeciesReference
stoichiometry: 1.0
species: 801300

463594
type: SpeciesReference
stoichiometry: 1.0
species: 801309

801573
type: Parameter
constant: true
units: 462238
value: 156.0

801639
type: Parameter
constant: false
units: dimensionless
value: NaN

801384
type: Reaction
reversible: true
product: 464152
product: 464164
has version: REACT 1090
reactant: 464128
kinetic law: 464176
fast: false
reactant: 464140
is: SBO:0000526
is version of: GO:0032403

464152
type: SpeciesReference
stoichiometry: 1.0
species: 801324

464164
type: SpeciesReference
stoichiometry: 1.0
species: 801304

464128
type: SpeciesReference
stoichiometry: 1.0
species: 801316

464140
type: SpeciesReference
stoichiometry: 1.0
species: 801327

801535
type: Parameter
constant: true
units: 462141
value: 156.0

801550
type: Parameter
constant: true
units: 462141
value: 156.0

801361
type: Reaction
product: 463303
reactant: 463291
reactant: 463278
reversible: true
kinetic law: 463340
fast: false
is: SBO:0000344
product: 463315
is version of: GO:0032403
product: 463327

463303
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463291
type: SpeciesReference
stoichiometry: 1.0
species: 801322

463278
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463315
type: SpeciesReference
stoichiometry: 1.0
species: 801324

463327
type: SpeciesReference
stoichiometry: 1.0
species: 801325

801609
type: Parameter
constant: true
units: 462008
value: 1.5

W3 CDTF: Fri Jul 30 16:23:23 BST 2010

801520
type: Parameter
constant: true
units: 462141
value: 12.0

801355
type: Reaction
product: 463002
is version of: GO:0032403
kinetic law: 463029
product: 463016
fast: false
product: 462989
reversible: true
reactant: 462976
is: SBO:0000344
reactant: 462963

463002
type: SpeciesReference
stoichiometry: 1.0
species: 801316

463016
type: SpeciesReference
stoichiometry: 1.0
species: 801318

462989
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462976
type: SpeciesReference
stoichiometry: 1.0
species: 801307

462963
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801561
type: Parameter
constant: true
units: 462238
value: 31.9

801627
type: Parameter
constant: false
units: dimensionless
value: NaN
name: percent SMAC release

801372
type: Reaction
kinetic law: 463739
product: 463727
reactant: 463715
is version of: GO:0043241
is: SBO:0000180
fast: false
reversible: true

463727
type: SpeciesReference
stoichiometry: 1.0
species: 801318

463715
type: SpeciesReference
stoichiometry: 1.0
species: 801321

801523
type: Parameter
constant: true
units: 462141
value: 12.0

801531
type: Parameter
constant: true
units: 462141
value: 12.0

801343
type: Reaction
product: 462540
is version of: GO:0006461
reactant: 462504
is: SBO:0000231
fast: false
reversible: true
product: 462528
kinetic law: 462552
reactant: 462516

462540
type: SpeciesReference
stoichiometry: 1.0
species: 801304

462504
type: SpeciesReference
stoichiometry: 1.0
species: 801306

462528
type: SpeciesReference
stoichiometry: 1.0
species: 801306

462516
type: SpeciesReference
stoichiometry: 1.0
species: 801299

801615
type: Parameter
constant: false
units: dimensionless
value: NaN
name: normalised Casp-9

801360
type: Reaction
is: SBO:0000344
product: 463226
reactant: 463213
product: 463252
product: 463239
reactant: 463200
fast: false
is version of: GO:0032403
kinetic law: 463265
reversible: true

463226
type: SpeciesReference
stoichiometry: 1.0
species: 801304

463213
type: SpeciesReference
stoichiometry: 1.0
species: 801310

463252
type: SpeciesReference
stoichiometry: 1.0
species: 801319

463239
type: SpeciesReference
stoichiometry: 1.0
species: 801316

463200
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801608
type: Parameter
constant: true
units: 462008
value: 2.3
name: t_Apop_0.5

W3 CDTF: Wed May 16 15:44:17 BST 2012

801603
type: Parameter
constant: true
units: 462141
value: 12.0

801611
type: Parameter
constant: false
units: dimensionless
value: NaN
name: free SMAC per XIAP

801398
type: Reaction
kinetic law: 464457
reactant: 464444
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464444
type: SpeciesReference
stoichiometry: 1.0
species: 801312

801403
type: Reaction
kinetic law: 464530
reactant: 464518
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464518
type: SpeciesReference
stoichiometry: 1.0
species: 801322

801506
type: Parameter
constant: true
units: 462238
value: 0.144

801411
type: Reaction
kinetic law: 464651
reactant: 464639
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464639
type: SpeciesReference
stoichiometry: 1.0
species: 801316

801537
type: Parameter
constant: true
units: 462238
value: 0.144

801552
type: Parameter
constant: true
units: 462190
value: 420.0

801545
type: Parameter
constant: true
units: 462190
value: 420.0

801414
type: Reaction
kinetic law: 464700
reactant: 464688
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464688
type: SpeciesReference
stoichiometry: 1.0
species: 801321

801422
type: Reaction
kinetic law: 464906
product: 464894
reactant: 464881
is version of: REACT 535
is: SBO:0000185
fast: false
reversible: true

464894
type: SpeciesReference
stoichiometry: 1.0
species: 801337

464881
type: SpeciesReference
stoichiometry: 1.0
species: 801336

801397
type: Reaction
kinetic law: 464431
reactant: 464419
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464419
type: SpeciesReference
stoichiometry: 1.0
species: 801309

801637
type: Parameter
constant: false
units: dimensionless
value: NaN

801525
type: Parameter
constant: true
units: 462141
value: 12.0

801502
type: Parameter
constant: true
units: 462141
value: 48.0

801382
type: Reaction
reactant: 464079
product: 464104
kinetic law: 464116
is version of: GO:0006461
fast: false
reactant: 464092
is: SBO:0000526
reversible: true

464079
type: SpeciesReference
stoichiometry: 1.0
species: 801318

464104
type: SpeciesReference
stoichiometry: 1.0
species: 801325

464092
type: SpeciesReference
stoichiometry: 1.0
species: 801327

801339
type: Reaction
kinetic law: 462371
product: 462359
is: SBO:0000393
fast: false
reversible: true
name: XIAP Production

462359
type: SpeciesReference
stoichiometry: 1.0
species: 801300

801390
type: Reaction
kinetic law: 464335
reactant: 464323
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464323
type: SpeciesReference
stoichiometry: 1.0
species: 801301

801402
type: Reaction
kinetic law: 464506
reactant: 464493
is part of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464493
type: SpeciesReference
stoichiometry: 1.0
species: 801330

801385
type: Reaction
kinetic law: 464238
product: 464226
reactant: 464201
product: 464213
reversible: true
fast: false
has version: REACT 1312
reactant: 464188
is: SBO:0000526
is version of: GO:0032403

464226
type: SpeciesReference
stoichiometry: 1.0
species: 801301

464201
type: SpeciesReference
stoichiometry: 1.0
species: 801327

464213
type: SpeciesReference
stoichiometry: 1.0
species: 801325

464188
type: SpeciesReference
stoichiometry: 1.0
species: 801319

801625
type: Parameter
constant: false
units: dimensionless
value: NaN
name: normalised Procasp-3

801370
type: Reaction
reactant: 463678
fast: false
reversible: true
is version of: GO:0006461
is: SBO:0000344
product: 463690
kinetic law: 463702
reactant: 463666

463678
type: SpeciesReference
stoichiometry: 1.0
species: 801318

463690
type: SpeciesReference
stoichiometry: 1.0
species: 801319

463666
type: SpeciesReference
stoichiometry: 1.0
species: 801301

801578
type: Parameter
constant: true
units: 462238
value: 0.0058

801643
type: Parameter
constant: false
units: dimensionless
value: NaN

462032
type: SBMLUnitsDef
unit: 462044
name: micromole

462044
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

801636
type: Parameter
constant: false
units: dimensionless
value: NaN

801605
type: Parameter
constant: true
units: 462008
value: 7.0
name: t_SMAC_0.5

801566
type: Parameter
constant: true
units: 462141
value: 4.45

801631
type: Parameter
constant: false
units: dimensionless
value: NaN
name: percent Apoptosome formation

801508
type: Parameter
constant: true
units: 462141
value: 156.0

801416
type: Reaction
kinetic law: 464724
reactant: 464712
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464712
type: SpeciesReference
stoichiometry: 1.0
species: 801327

801351
type: Reaction
product: 462782
kinetic law: 462794
is version of: GO:0006461
reactant: 462770
reactant: 462758
reversible: true
fast: false
is: SBO:0000526

462782
type: SpeciesReference
stoichiometry: 1.0
species: 801316

462770
type: SpeciesReference
stoichiometry: 1.0
species: 801315

462758
type: SpeciesReference
stoichiometry: 1.0
species: 801304

801412
type: Reaction
kinetic law: 464675
reactant: 464663
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: true

464663
type: SpeciesReference
stoichiometry: 1.0
species: 801319

801387
type: Reaction
product: 464274
fast: false
reversible: true
has version: REACT 1090
kinetic law: 464286
reactant: 464262
is version of: GO:0006461
reactant: 464250
is: SBO:0000526

464274
type: SpeciesReference
stoichiometry: 1.0
species: 801330

464262
type: SpeciesReference
stoichiometry: 2.0
species: 801327

464250
type: SpeciesReference
stoichiometry: 1.0
species: 801312