2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v272 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v596 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v567 2(ErbB2)#P:GAP -> R_degraded k60b kd60
v26 EGF:ErbB1:ErbB2 + ATP -> EGF:ErbB1:ErbB2:ATP k122 kd122
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v342 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
2(EGF:ErbB1)#P:GAP:Grb2:Sos , endosomal membrane
v429 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v752 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v726 (ERK#P#P)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v298 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:Sos , plasma membrane
v321 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
2(ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v626 PI3K + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
v521 Pase3 + ERK#P -> ERK#P:Pase3 k58 kd58
v786 HRG:ErbB3 + ErbB2 -> (HRG:ErbB3):ErbB2 k120 kd120
2(EGF:ErbB1)#P:GAP:Shc , endosomal membrane
2(EGF:ErbB1)#P:GAP:Shc , plasma membrane
v167 2(EGF:ErbB1)#P:GAP:Shc -> 2(EGF:ErbB1)#P:GAP:Shc k6 kd6
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v577 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Sos , plasma membrane
v355 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
((HRG:ErbB3):ErbB2):ATP , plasma membrane
((HRG:ErbB3):ErbB2) , endosomal membrane
v41 (HRG:ErbB3):ErbB2) + ATP -> (HRG:ErbB3):ErbB2):ATP k122 kd122
v648 AKT#P + Pase4 -> AKT#P#P:Pase4 k75 kd75
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v191 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP k7 kd7
v809 (ErbB1:ErbB3)#P + ATP -> (EGF:ErbB1:ErbB3):ATP k123 kd123
2(ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
2(ErbB2)2:Gab1#P##:Pase9t , plasma membrane
2(ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v778 Pase9t + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)2:Gab1#P##:Pase9t k118 kd118
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v322 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB4:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
(ErbB4:ErbB2)#P:GAP:(Shc#P) , plasma membrane
v184 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k6b kd6b
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
(EGF:ErbB1:ATP::EGF:ErbB1:Inh)-HalfActive , plasma membrane
v803 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k123 kd123
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , endosomal membrane
(ErbB1:ErbB4)#P:GAP:(Shc#P) , endosomal membrane
v228 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v530 2(EGF:ErbB1)#P:GAP:Shc -> R_degraded k60 kd60
(ErbB1:ErbB4)#P:GAP:Grb2:Sos , endosomal membrane
(ErbB1:ErbB4)#P:GAP:Grb2 , endosomal membrane
v254 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17
v206 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v547 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
(EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive , plasma membrane
v859 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k123 kd123
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
v407 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
v97 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
2(ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v818 2(ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 , plasma membrane
v704 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k106 kd106
(ErbB4:ErbB2)#P:GAP:Shc , plasma membrane
v379 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22
(ErbB1:ErbB4)#P:GAP:Grb2:cPP , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2 , plasma membrane
v66 (ErbB1:ErbB4)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k4b kd4
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v152 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v560 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
(ErbB4:ErbB2)#P:GAP , endosomal membrane
v467 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37
v764 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v113 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v493 MEK + Raf#P -> MEK:Raf#P k44 kd52
(ErbB1:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v598 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP , plasma membrane
v77 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k4b kd4
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P , plasma membrane
v728 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP , plasma membrane
v162 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k5 kd5
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v209 ErbB3 + -> (HRG:ErbB3) k10b kd10
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , plasma membrane
v395 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
(EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , cytoplasm
(ErbB3:ErbB2)#P:GAP:Grb2 , endosomal membrane
v590 (ErbB3:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t , plasma membrane
v773 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117
v523 ErbB1:ATP -> R_degraded k60 kd60
v317 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP , cytoplasm
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) , plasma membrane
v821 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k123 kd123
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
v628 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68b
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v799 ErbB1_h:ATP + -> ErbB1_h:ATP k6 kd6
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
(ErbB1:ErbB3)#P:GAP:Grb2:Sos , endosomal membrane
v357 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
2(EGF:ErbB1)#P:GAP:Grb2:cPP , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2 , plasma membrane
v43 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k4 kd4
(ErbB2:ErbB3)#P:RTK_Pase , endosomal membrane
v654 RTK_Pase + (ErbB3:ErbB2)#P -> (ErbB2:ErbB3)#P:RTK_Pase k94 kd94
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P , plasma membrane
v622 PI3K + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v542 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v219 Grb2 + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v92 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
(ErbB1:ErbB3)#P:GAP:(Shc#P) , plasma membrane
v449 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v532 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> R_degraded k60 kd60
(EGF:ErbB1:ATP::EGF:ErbB1_h:ATP) , plasma membrane
v850 EGF:ErbB1:ATP + EGF:ErbB1_h:ATP -> EGF:ErbB1:ATP::EGF:ErbB1_h:ATP k2 kd2
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1 , plasma membrane
v716 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 , plasma membrane
v637 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k68 kd68b
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v149 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
v10 EGF:ErbB1:ATP + ErbB3 -> EGF:ErbB1:ErbB3 k2b kd2b
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
v279 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v165 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P k6 kd6
2(ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
v575 2(ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
v761 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v678 ErbB2 + ErbB3 -> (ErbB2:ErbB3) k103 kd103
v511 (ERK#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK k53 kd53
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v305 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P) , endosomal membrane
v479 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P , plasma membrane
v776 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k117 kd117
2(ErbB2)#P:GAP:Grb2 , endosomal membrane
v505 Pase2 + (MEK#P)_i -> (MEK#P:Pase2)_i k50 kd50
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v345 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP , cytoplasm
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1 , plasma membrane
v31 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k122 kd122
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , endosomal membrane
v610 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v558 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v792 ErbB1:ATP + (HRG:ErbB3) -> (HRG:ErbB3:ErbB1) k120b kd120
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v174 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k6 kd6
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v335 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v687 PTEN + PIP2 -> PIP3:PTEN k104 kd104
v535 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + -> R_degraded k60 kd60
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v329 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v640 PIP3 + AKT#P -> PIP3:AKT#P k69 kd69
v212 Grb2 + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) , endosomal membrane
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , endosomal membrane
v619 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k65 kd65
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2 , plasma membrane
v694 (ErbB4:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
(ErbB1:ErbB2)#P:GAP:Shc , plasma membrane
v369 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b
v514 (ERK#P#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK#P k55 kd55
v666 ErbB2 + Inh -> ErbB2:Inh k98 kd98
(ErbB3:ErbB2)#P:GAP , endosomal membrane
v238 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd24
2(ErbB2)#P:GAP:(Shc#P) , endosomal membrane
v482 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v823 (ErbB1:ErbB4)#P + ATP -> (HRG:ErbB4:ErbB1):ATP k123 kd123
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v261 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
2(EGF:ErbB1)#P:GAP:(Shc#P) , endosomal membrane
v446 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37
v231 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v104 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
v711 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v544 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
(ErbB1:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
v75 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v136 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
(EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , plasma membrane
v862 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k123h kd123h
2(ErbB2)#P:GAP:Grb2:Sos , plasma membrane
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v425 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v22 (EGF:ErbB1:ErbB3) + ATP -> (EGF:ErbB1:ErbB3):ATP k122 kd122
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i , plasma membrane
v748 (ERK#P#P)_i + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k111 kd111
(ErbB1:ErbB3)#P:GAP:Grb2 , plasma membrane
v690 (ErbB1:ErbB3)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 k105 kd105
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v121 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v59 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
v470 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v735 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
2(ErbB2)#P:GAP:(Shc#P) , plasma membrane
v193 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k7 kd7
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v145 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
2(EGF:ErbB1)#P:GAP:Grb2:Sos#P , plasma membrane
v485 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v277 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v601 (EGF:ErbB1:ErbB3) -> R_degraded k62b kd60b
v573 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v347 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v757 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v644 AKT#P#P + PIP3:PDK1 -> PIP3:AKT#P:PDK1 k72 kd72
v507 ERK + MEK#P#P -> ERK:MEK#P#P k52 kd44
(ErbB4:ErbB2)#P:GAP:Shc , endosomal membrane
v180 (ErbB4:ErbB2)#P:GAP:Shc -> (ErbB4:ErbB2)#P:GAP:Shc k6 kd6
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v50 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4 kd4
(ErbB3:ErbB2)#P:GAP:Shc , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P) , plasma membrane
v381 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23
2(EGF:ErbB1)#P:GAP:Grb2 , endosomal membrane
v526 2(EGF:ErbB1)#P:GAP:Grb2 -> R_degraded k60 kd60
((HRG:ErbB4):ErbB2) , endosomal membrane
v202 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8
v564 (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v403 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v668 ErbB3 + Inh -> ErbB3:Inh k100 kd100
(ErbB1:ErbB4)#P:GAP , endosomal membrane
v196 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b
v814 2(ErbB2)#P + ATP -> ErbB2:ErbB2#P:ATP k123 kd123
v556 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v148 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v233 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
v745 ERK#P#P + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v420 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v289 Ras:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 , plasma membrane
v713 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k107 kd107
v463 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v685 ErbB2 + ErbB4:Inh -> ErbB4:Inh:ErbB2 k103 kd103
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v257 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v760 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v489 Raf + Pase1 -> Raf#P:Pase1 k43 kd43
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v594 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v24 2(EGF:ErbB1:ATP) + ATP -> 2(EGF:ErbB1):ATP k122 kd122
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v71 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v158 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k5 kd5
v28 EGF:ErbB1:ErbB4 + ATP -> EGF:ErbB1:ErbB4:ATP k122 kd122
v472 Sos + (Shc#P):Grb2 -> (Shc#P):Grb2:Sos k40 kd40
2(ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
v313 Ras_activated:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v795 EGF + ErbB1_h:Inh -> EGF:ErbB1_h:Inh k1 kd1
v603 (HRG:ErbB3:ErbB1) -> R_degraded k62b kd60b
2(EGF:ErbB1_h:ATP)-FullActive , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v353 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB2)#P:GAP:Grb2 , plasma membrane
v701 PIP2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> PI3K k106 kd106
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) , endosomal membrane
v618 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65
v376 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v63 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
(ErbB1:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
(ErbB1:ErbB2)#P:GAP , endosomal membrane
v451 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37
v245 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17
2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
v215 2(EGF:ErbB1)#P:GAP + Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , plasma membrane
v398 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
(ErbB2:ErbB4)#P:RTK_Pase , endosomal membrane
v663 RTK_Pase + (ErbB4:ErbB2) -> (ErbB2:ErbB4)#P:RTK_Pase k95 kd95
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v88 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v12 EGF:ErbB1:ATP + ErbB2 -> (EGF:ErbB1:ErbB2) k2b kd2b
v528 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60
v826 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2):ATP k123 kd123
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
v633 PIP3 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v48 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k4 kd4
v275 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v377 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b
v787 (HRG:ErbB3) + ErbB2 -> (HRG:ErbB3):ErbB2) k120 kd120
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v301 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v719 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
v454 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v606 (HRG:ErbB4):ErbB2) -> R_degraded k62b kd60b
v554 (ErbB1:ErbB4)#P:GAP:Grb2 -> R_degraded k60b kd60
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v15 EGF:ErbB1:Inh + ErbB2 -> EGF:ErbB1:Inh:ErB2 k2b kd2b
(ErbB3:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
v284 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v170 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k6 kd6
(ErbB3:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
v581 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60
v683 ErbB2:Inh + ErbB3 -> ErbB3:ErbB2:Inh k103 kd103
v516 (ERK#P#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k56 kd56
(ErbB1:ErbB4)#P:RTK_Pase , endosomal membrane
v651 RTK_Pase + (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P:RTK_Pase k94b kd94
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v310 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
ErbB3/4:ErbB2:Gab1#P##:Pase9t , plasma membrane
v781 Pase9t + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k118 kd118
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
v325 Ras_activated:GTP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP , plasma membrane
v129 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k5 kd5b
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , plasma membrane
v615 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65
v186 (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P k7 kd7
v797 EGF:ErbB1_h:Inh + EGF:ErbB1_h:Inh -> 2(EGF:ErbB1_h:Inh) k2 kd2
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v84 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v410 (Ras:GTP)_i + Raf -> (Raf:Ras:GTP)_i k28 kd28
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v100 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v675 EGF:ErbB1#P + ErbB3#P -> (ErbB1:ErbB3)#P k102 kd102
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v540 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
v217 Grb2 + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
v697 PIP2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v61 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
(ErbB1:ErbB2)#P:GAP:Shc , endosomal membrane
v372 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b
v447 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37
v828 ErbB1 + ATP -> ErbB1:ATP k122 kd122
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v116 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b
v8 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP) k2 kd2
v549 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v466 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37
v80 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
v731 ERK#P#P + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v303 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2 , endosomal membrane
v141 cPP + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k5 kd5b
2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
v27 EGF:ErbB1:ErbB3 + ATP -> EGF:ErbB1:ErbB3:ATP k122 kd122
(ErbB1:ErbB3)#P:RTK_Pase , endosomal membrane
v753 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v428 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34
v126 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
v204 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v172 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k6 kd6
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v583 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60
v360 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v46 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v333 2(ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v816 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k123 kd123
2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
v327 Ras_activated:GTP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v512 MEK#P#P + ERK#P -> ERK:MEK#P#P k53 kd53
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , plasma membrane
(ErbB1:ErbB4)#P:GAP:(Shc#P) , plasma membrane
v552 (ErbB1:ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
2(EGF:ErbB1)#P:GAP:(Shc#P) , plasma membrane
v444 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37
v56 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v412 Ras_activated:GTP + Raf#P -> Raf:Ras:GTP k29 kd29
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v102 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
v709 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v384 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23
(ErbB1:ErbB3)#P:GAP:Grb2 , endosomal membrane
v253 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v438 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34
(EGF:ErbB1:ATP::EGF:ErbB1:Inh) , plasma membrane
v5 EGF:ErbB1:ATP + EGF:ErbB1:Inh -> (EGF:ErbB1:ErbB1):Inh k2 kd2
v569 2(ErbB2)#P:GAP:(Shc#P) -> R_degraded k60b kd60
v673 EGF:ErbB1#P + EGF:ErbB1#P -> 2(EGF:ErbB1)#P k102 kd102
(EGF:ErbB1:ErbB3)#P:Inh , plasma membrane
v20 EGF:ErbB1:ATP + ErbB3:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v315 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
This is A431 IERMv1.0 model described in the article Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger and Peter K Sorger. Molecular Systems Biology 2009; 5:239. PMID: 19156131 , DOI: 10.1038/msb.2008.74 Abstract: The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood how different ligands induce different responses and how this is affected by oncogenic mutations. To quantify signal flow through ErbB-activated pathways we have constructed, trained and analyzed a mass action model of immediate-early signaling involving ErbB1-4 receptors (EGFR, HER2/Neu2, ErbB3 and ErbB4), and the MAPK and PI3K/Akt cascades. We find that parameter sensitivity is strongly dependent on the feature (e.g. ERK or Akt activation) or condition (e.g. EGF or heregulin stimulation) under examination and that this context dependence is informative with respect to mechanisms of signal propagation. Modeling predicts log-linear amplification so that significant ERK and Akt activation is observed at ligand concentrations far below the K(d) for receptor binding. However, MAPK and Akt modules isolated from the ErbB model continue to exhibit switch-like responses. Thus, key system-wide features of ErbB signaling arise from nonlinear interaction among signaling elements, the properties of which appear quite different in context and in isolation. The sbml model is available as supplemental material to the article and at http://www.cdpcenter.org/resources/models/chen-et-al-2008/ . It was slightly changed to make it valid SBML and to incorporate the step functions, described in the readme file and needed for inhibitor preincubation. the equilibration processes end at 1800 sec, so to reproduce the dynamics shown in the publication and supplemental material, only the time points after 1800 need to be considered. The parameter set is the hand fitted one used for Sfigure 3 in the supplemental materials. All species are in molecules, apart from HRG, EGF and Inh, which are in M. The results shown in SFigure 3 can be calculated dividing the parameters ERK_PP , AKT_PP and ERB_B1_P_tot by ERK_t , AKT_t and EGFR_t , respectively. Somehow we did not find the right scaleing factor for the phosphorylated ErbB1 receptor. Therefore the model does only qualitatively reproduces the timecourses shown in the first row of Sfigure 3. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Nov������re N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v268 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v153 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
v338 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v294 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v468 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v262 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v765 AKT#P#P + Raf#P -> AKT:P:P:Raf:P:Ser k114 kd114
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P , endosomes
v199 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8 kd8
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v112 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b
v494 MEK#P + Raf#P -> MEK#P:Raf#P k44 kd52
v811 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1):ATP k123 kd123
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
v727 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
(ErbB3:ErbB2)#P:GAP:Grb2 , plasma membrane
v241 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v33 2(ErbB2)#P:GAP:Grb2:Gab1 + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v659 RTK_Pase + (EGF:ErbB1:ErbB4) -> (ErbB1:ErbB4)#P:RTK_Pase k95 kd95
(ErbB1:ErbB4)#P:GAP:Shc , endosomal membrane
v394 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23
2(ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
v83 2(ErbB2)#P:GAP:Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v524 2(EGF:ErbB1:ATP) -> R_degraded k60 kd60
v789 HRG:ErbB3 + ErbB1:ATP -> (HRG:ErbB3:ErbB1) k120b kd120
v318 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB1:ErbB3)#P:GAP:Shc , plasma membrane
2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v629 PIP3 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v224 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 , plasma membrane
v706 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k106 kd106
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v271 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v623 PI3K + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , plasma membrane
v456 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37
v68 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
(ErbB1:ErbB3)#P:GAP:Grb2:Sos , plasma membrane
v250 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17
2(EGF:ErbB1)#P:RTK_Pase , endosomal membrane
v855 EGF:ErbB1:ATP::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k122 kd122
v265 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v93 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v17 ErbB4 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB4 k2b kd2b
v743 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
v418 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v287 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v181 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k6b kd6b
(ErbB4:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
v280 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
(ErbB3:ErbB2)#P:GAP:Shc , endosomal membrane
v382 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23
v350 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
2(EGF:ErbB1)#P:GAP:Grb2:Gab1 , plasma membrane
v36 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k122 kd122
v306 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB4:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2 , endosomal membrane
v109 cPP + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k5b kd5b
v480 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v156 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5
v565 (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
v125 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v506 Pase2 + MEK#P -> MEK#P:Pase2 k50 kd50
v724 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k110 kd110
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P , plasma membrane
v611 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k64 kd64
v767 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser k115 kd115
v793 ErbB1:ATP + (HRG:ErbB4) -> (HRG:ErbB4:ErbB1) k120b kd120
(ErbB1:ErbB4)#P:GAP:Shc , plasma membrane
v391 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23
v336 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB1:ErbB3)#P:GAP:Shc , endosomal membrane
v519 ERK + Pase3 -> ERK#P:Pase3 k57 kd57
v406 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v784 HRG + ErbB3 -> HRG:ErbB3 k119 kd119
v671 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101
v243 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v330 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v39 (HRG:ErbB4):ErbB2 + ATP -> (HRG:ErbB4):ErbB2:ATP k122 kd122
v236 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v693 (ErbB3:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
v368 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22
(ErbB1:ErbB2)#P:RTK_Pase , endosomal membrane
v657 RTK_Pase + (EGF:ErbB1:ErbB2) -> (ErbB1:ErbB2)#P:RTK_Pase k95 kd95
v415 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v105 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b
v680 ErbB2#P + ErbB3#P -> (ErbB3:ErbB2)#P k103 kd103
v545 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
v430 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v702 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k106 kd106
(ErbB1:ErbB3)#P:GAP , endosomal membrane
v452 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37
v64 (ErbB1:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k4b kd4
v717 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
(ErbB1:ErbB2)#P:GAP:(Shc#P) , plasma membrane
v475 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v150 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
v122 cPP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b
v501 MEK#P + Pase2 -> MEK#P#P:Pase2 k49 kd49
v13 EGF:ErbB1:ATP + ErbB3 -> (EGF:ErbB1:ErbB3) k2b kd2b
v282 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v579 (ErbB3:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60
v356 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
((HRG:ErbB4):ErbB2):ATP , endosomal membrane
v42 (HRG:ErbB4):ErbB2) + ATP -> (HRG:ErbB4):ErbB2):ATP k122 kd122
v762 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v649 PDK1 + PIP3 -> PIP3:PDK1 k76 kd76
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
v736 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v308 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v185 (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P k7 kd7
v613 ERK#P#P + Sos -> (ERK#P#P):Sos k64 kd64
v433 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34
2(EGF:ErbB1):Gab1#P##:Pase9t , plasma membrane
v531 2(EGF:ErbB1)#P:GAP:(Shc#P) -> R_degraded k60 kd60
v636 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k68 kd68b
v207 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8
v502 MEK + Pase2 -> MEK#P:Pase2 k49 kd49
v588 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
v365 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v52 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v408 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v819 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v705 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k106 kd106
v380 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v138 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v387 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23
v652 RTK_Pase + 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P:RTK_Pase k94 kd94
v1 EGF + ErbB1:ATP -> EGF:ErbB1:ATP k1 kd1
ErbB1:ErbB:Gab1#P##:Pase9t , plasma membrane
v782 Pase9t + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB1:ErbB:Gab1#P##:Pase9t k118 kd118
v750 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v557 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v232 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63
v421 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v290 (Ras:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
v714 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v78 2(ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v258 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v163 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k6 kd6
v595 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v646 AKT#P + Pase4 -> AKT#P:Pase4 k73 kd73
v396 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v189 (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P k7 kd7
v807 (ErbB1:ErbB2)#P + ATP -> EGF:ErbB1:ErbB2:ATP k123 kd123
v591 (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60
ErbB3/4:ErbB2:Gab1#P## , plasma membrane
v774 Pase9t + ErbB3/4:ErbB2:Gab1#P## -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k117 kd117
v320 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v343 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v801 ErbB1_h:ATP + EGF -> EGF:ErbB1:ATP k10b kd10
v29 ErbB2:ErbB2#P + ATP -> ErbB2:ErbB2#P:ATP k122 kd122
v608 (ErbB4:ErbB2) -> R_degraded k62b kd60b
v358 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v655 RTK_Pase + (ErbB4:ErbB2)#P -> (ErbB2:ErbB4)#P:RTK_Pase k94 kd94
v117 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b
v497 MEK#P#P + Raf#P -> MEK#P:Raf#P k47 kd47
v220 (ErbB1:ErbB2)#P:GAP + Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24
v732 (ERK#P#P)_i + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v246 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17
v533 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60 kd60
(EGF:ErbB1:Inh::EGF:ErbB1_h:ATP) , plasma membrane
v851 EGF:ErbB1:Inh + EGF:ErbB1_h:ATP -> EGF:ErbB1:Inh::EGF:ErbB1_h:ATP k2 kd2
v638 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k68 kd68b
v399 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v89 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v664 ErbB2#P + ErbB2#P -> 2(ErbB2)#P k96 kd96
v229 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v276 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v459 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37
v346 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
(EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive , plasma membrane
v860 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k123h kd123h
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t , endosomal membrane
v559 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v423 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v175 2(EGF:ErbB1)#P:GAP:Grb2 + -> 2(EGF:ErbB1)#P:GAP:Grb2 k6 kd6
v720 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k108 kd108
v292 (Ras:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v586 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60
v688 2(EGF:ErbB1)#P:GAP:Grb2 + Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 k105 kd105
v553 (ErbB1:ErbB3)#P:GAP:Grb2 -> R_degraded k60b kd60
v370 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b
v515 ERK#P#P + Pase3 -> ERK#P#P:Pase3 k56 kd56
v483 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v161 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k5 kd5
v570 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
v130 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b
v642 PDK1 + PIP3:AKT -> PIP3:AKT:PDK1 k70 kd70
v392 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23
v772 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117
v441 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v222 (ErbB1:ErbB4)#P:GAP + Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24
v411 (Ras_activated:GTP)_i + (Raf#P)_i -> (Raf:Ras:GTP)_i k29 kd29
v676 EGF:ErbB1#P + ErbB4#P -> (ErbB1:ErbB4)#P k102 kd102
v101 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
v248 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17
v541 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
(EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) , plasma membrane
v853 EGF:ErbB1_h:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh k2 kd2
v698 PIP2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v373 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b
v60 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v471 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v146 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v9 EGF:ErbB1:ATP + ErbB2 -> EGF:ErbB1:ErbB2 k2b kd2b
v278 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v348 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v435 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v758 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k113 kd113
v304 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
v107 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b
v487 Pase1 + (Raf#P)_i -> (Raf#P:Pase1)_i k42 kd42
v592 (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60
v69 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v722 PIP3 + Shp -> PIP3:Shp k109 kd109
v203 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8
v389 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23
v584 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60
v361 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v47 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k4 kd4
v517 (ERK#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k57 kd57
v197 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v815 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v234 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v96 (ErbB4:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k4b kd4
v746 (ERK#P#P)_i + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v260 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v641 PDK1 + PIP3:AKT#P -> PIP3:AKT#P:PDK1 k70 kd70
v413 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v824 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2:ATP k123 kd123
v710 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v543 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
v385 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23
v143 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v72 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
v437 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34
v4 EGF + ErbB1:Inh -> EGF:ErbB1:Inh k1 kd1
v273 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v159 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5
v568 2(ErbB2)#P:GAP:Shc -> R_degraded k60b kd60
v755 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v672 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101
v299 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v473 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v770 Pase9t + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1):Gab1#P##:Pase9t k117 kd117
v120 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v499 (MEK#P#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k48 kd48
v339 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v796 EGF:ErbB1:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1:ErbB1_h:Inh k2 kd2
v604 (HRG:ErbB4:ErbB1) -> R_degraded k62b kd60b
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
v734 (ERK#P#P)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v200 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b
v168 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k6 kd6
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
v216 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24
v401 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v194 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8b kd8b
v812 (ErbB1:ErbB3)#P + ATP -> EGF:ErbB1:ErbB3:ATP k123 kd123
v486 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v779 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118
v529 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60 kd60
v323 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v827 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2):ATP k123 kd123
v634 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k68 kd68b
v363 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v508 MEK#P#P + ERK#P -> ERK#P:MEK#P#P k52 kd44
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v49 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4 kd4
v660 RTK_Pase + 2(EGF:ErbB1:ATP) -> 2(EGF:ErbB1)#P:RTK_Pase k95 kd95
v255 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v225 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24
v98 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
v67 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v455 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37
v856 EGF:ErbB1:Inh::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k122 kd122
v419 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v16 ErbB3 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB3 k2b kd2b
v285 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
v742 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v712 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v684 ErbB2:Inh + ErbB4 -> ErbB4:ErbB2:Inh k103 kd103
v311 Ras_activated:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v114 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b
v805 EGF:ErbB1:ErbB1_h:Inh + ATP -> k122 kd122
v351 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v464 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37
v729 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k110 kd110
v616 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k65 kd65
v187 (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P k7 kd7
v490 Raf + Pase1 -> (Raf#P:Pase1)_i k43 kd43
v798 EGF + ErbB1_h:ATP -> EGF:ErbB1_h:ATP k1 kd1
v85 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
v631 PIP3 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v44 2(EGF:ErbB1)#P:GAP:Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k4 kd4
v625 PI3K + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
v375 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b
v520 ERK + Pase3 -> (ERK#P:Pase3)_i k57 kd57
v785 ErbB4 + HRG -> HRG:ErbB4 k119 kd119
v397 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v662 RTK_Pase + (ErbB3:ErbB2) -> (ErbB2:ErbB3)#P:RTK_Pase k95 kd95
v808 (ErbB1:ErbB2)#P + ATP -> (EGF:ErbB1:ErbB2):ATP k123 kd123
v550 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v142 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v227 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24
v707 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v457 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v754 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v858 EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k122 kd122
v127 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
v18 EGF:ErbB1:ATP + ErbB2:Inh -> (EGF:ErbB1:ErbB2):Inh k2b kd2b
(ErbB1:ErbB3)#P:GAP:Grb2:cPP , plasma membrane
v65 (ErbB1:ErbB3)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k4b kd4
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v32 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k122 kd122
v476 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v741 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k111 kd111
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v151 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v283 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v580 (ErbB4:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60
v763 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v650 RTK_Pase + (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P:RTK_Pase k94b kd94
v513 ERK#P#P + MEK#P#P -> ERK#P:MEK#P#P k55 kd55
v307 Ras:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v492 MEK + (Raf#P)_i -> (MEK:Raf#P)_i k44 kd52
v597 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
v695 PIP2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v612 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k64 kd64
v57 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v445 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37
v239 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd24
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v208 ErbB1:ATP + EGF -> EGF:ErbB1:ATP k10b kd10
v439 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v81 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v6 EGF:ErbB1:Inh + EGF:ErbB1:Inh -> 2(EGF:ErbB1:Inh) k2 kd2
v522 Pase3 + (ERK#P)_i -> (ERK#P:Pase3)_i k58 kd58
v820 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v627 PI3K + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v139 cPP + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k5 kd5b
v269 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v341 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v751 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k112 kd112
v426 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v295 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v469 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v691 (ErbB1:ErbB4)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 k105 kd105
v263 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v495 MEK#P + Raf#P -> MEK:Raf#P k45 kd45
v448 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37
v600 (EGF:ErbB1:ErbB2) -> R_degraded k62b kd60b
v548 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v79 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v574 2(ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60
v34 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v677 ErbB2#P + ErbB2 -> ErbB2:ErbB2#P k103 kd103
v510 (MEK#P#P)_i + (ERK#P)_i -> MEK#P#P:ERK#P k52 kd44
v645 AKT#P#P + Pase4 -> AKT#P#P:Pase4 k74 kd74
v190 (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P k7 kd7
v478 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v775 Pase9t + ErbB1:ErbB:Gab1#P## -> ErbB1:ErbB:Gab1#P##:Pase9t k117 kd117
v504 (MEK#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k49 kd49
v319 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
2(ErbB2)#P:GAP:Grb2:cPP , plasma membrane
v123 cPP + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:cPP k5 kd5b
v802 (EGF:ErbB1:ErbB1):Inh + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k122 kd122
v609 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64
v359 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v737 ERK#P#P + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
v624 PI3K + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
v251 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17
2(ErbB2)#P:RTK_Pase , endosomal membrane
v334 2(ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v221 (ErbB1:ErbB3)#P:GAP + Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24
v404 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
(ErbB3:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
v94 (ErbB3:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k4b kd4
v669 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P k101 kd101
v534 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60
v328 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v852 EGF:ErbB1_h:ATP + EGF:ErbB1_h:ATP -> 2(EGF:ErbB1_h:ATP) k2 kd2
v266 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v55 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v281 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v110 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b
v103 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b
v725 ERK#P#P + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
v297 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v135 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v267 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v337 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v602 (EGF:ErbB1:ErbB4) -> R_degraded k62b kd60b
v21 (EGF:ErbB1:ErbB2) + ATP -> (EGF:ErbB1:ErbB2):ATP k122 kd122
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P , plasma membrane
v747 ERK#P#P + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k111 kd111
v422 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v689 (ErbB1:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
v316 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v198 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8
v166 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP k6 kd6
v576 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v354 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v331 Ras_activated:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v40 (HRG:ErbB3):ErbB2 + ATP -> (HRG:ErbB3):ErbB2:ATP k122 kd122
v647 AKT + Pase4 -> AKT#P:Pase4 k75 kd75
v810 (ErbB1:ErbB4)#P + ATP -> (EGF:ErbB1:ErbB4):ATP k123 kd123
v621 PI3K + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v192 2(ErbB2)#P:GAP:Shc -> 2(ErbB2)#P:GAP:Shc k7 kd7
v484 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v777 Pase9t + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1):Gab1#P##:Pase9t k118 kd118
v91 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v416 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v106 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b
v681 ErbB2#P + ErbB4#P -> (ErbB4:ErbB2)#P k103 kd103
v546 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v223 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v703 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k106 kd106
v378 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b
v247 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17
(EGF:ErbB1:Inh::EGF:ErbB1_h:Inh) , plasma membrane
v854 EGF:ErbB1_h:Inh + EGF:ErbB1:Inh -> EGF:ErbB1_h:Inh::EGF:ErbB1:Inh k2 kd2
v563 (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
v667 ErbB4 + Inh -> ErbB4:Inh k99 kd99
v14 EGF:ErbB1:ATP + ErbB4 -> (EGF:ErbB1:ErbB4) k2b kd2b
v555 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v309 Ras:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v147 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v288 (Ras:GTP)_i + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v462 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v76 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k4b kd4
v759 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v434 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34
v488 Pase1 + Raf#P -> Raf#P:Pase1 k42 kd42
v134 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v593 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v23 (EGF:ErbB1:ErbB4) + ATP -> (EGF:ErbB1:ErbB4):ATP k122 kd122
v37 (HRG:ErbB3:ErbB1) + ATP -> (HRG:ErbB3:ErbB1):ATP k122 kd122
v589 (ErbB4:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60
v366 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v53 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v388 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23
v653 RTK_Pase + 2(ErbB2)#P -> 2(ErbB2)#P:RTK_Pase k94 kd94
v2 (ErbB2:ErbB3) + EGF -> (ErbB3:ErbB2)#P k1c kd1c
v518 ERK#P + Pase3 -> ERK#P#P:Pase3 k57 kd57
v783 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k118 kd118
v312 (Ras_activated:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v218 Grb2 + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24
v38 (HRG:ErbB4:ErbB1) + ATP -> (HRG:ErbB4:ErbB1):ATP k122 kd122
v700 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106
v617 ERK#P#P + Sos#P -> (ERK#P#P):Sos k65 kd65
v450 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37
v62 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v244 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v291 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v829 ErbB1_h + ATP -> ErbB1_h:ATP k122 kd122
v715 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v259 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v87 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v11 ErbB4 + EGF:ErbB1:ATP -> EGF:ErbB1:ErbB4 k2b kd2b
v679 ErbB2 + ErbB4 -> ErbB2:ErbB4 k103 kd103
v160 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5
v274 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v344 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v30 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v431 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34
v300 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v474 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v205 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8
v118 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b
v500 MEK#P#P + Pase2 -> MEK#P#P:Pase2 k48 kd48
v173 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k6 kd6
v718 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v605 (HRG:ErbB3):ErbB2) -> R_degraded k62b kd60b
v817 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k123 kd123
v733 ERK#P#P + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
v400 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v665 ErbB1 + Inh -> ErbB1:Inh k97 kd97
v90 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v237 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd63
v324 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v128 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k5 kd5b
v635 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k68 kd68b
v230 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v362 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v256 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v137 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v861 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k123 kd123
v409 Ras:GTP + Raf -> Raf:Ras:GTP k28 kd28
v749 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
v99 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v674 ErbB2#P + EGF:ErbB1#P -> (ErbB1:ErbB2)#P k102 kd102
v424 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v721 PIP3 + PTEN -> PIP3:PTEN k109 kd109
v293 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v155 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5
v286 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v766 AKT#P#P + (Raf#P)_i -> AKT:P:P:Raf:P:Ser_i k114 kd114
v115 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b
v572 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v133 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v730 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v643 PIP3:PDK1 + AKT#P -> PIP3:AKT:PDK1 k71 kd71
v302 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v179 (ErbB3:ErbB2)#P:GAP:Shc ->(ErbB3:ErbB2)#P:GAP:Shc k6b kd6b
v607 (ErbB3:ErbB2) -> R_degraded k62b kd60b
v427 (Shc#P) + Grb2:Sos -> (Shc#P):Grb2:Sos k33 kd33
v525 2(EGF:ErbB1)#P:GAP -> R_degraded k60 kd60
v790 HRG:ErbB4 + ErbB1:ATP -> (HRG:ErbB4:ErbB1) k120b kd120
v249 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v630 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K + PIP3 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v201 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b
v171 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k6 kd6
v582 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60
v332 (Ras_activated:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v45 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4 kd4
v656 RTK_Pase + (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P:RTK_Pase k94 kd94
v402 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v813 (ErbB1:ErbB4)#P + ATP -> EGF:ErbB1:ErbB4:ATP k123 kd123
v699 PIP2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106
v374 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b
v744 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v686 Shp + PIP2 -> PIP3:Shp k104 kd104
v551 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v436 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34
v108 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b
v708 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v383 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23
v70 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
v458 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37
v723 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k110 kd110
v252 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v481 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v157 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5
v19 EGF:ErbB1:ATP + ErbB4:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b
v390 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23
v585 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60
v768 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser_i k115 kd115
v314 (Ras_activated:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v794 ErbB1_h + Inh -> ErbB1_h:Inh k97c kd97c
v352 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v214 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24
v696 PIP2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v371 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b
v58 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v240 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd63
v527 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> R_degraded k60 kd60
v414 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v825 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2:ATP k123 kd123
v632 PIP3 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v386 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23
v144 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v440 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v658 RTK_Pase + (EGF:ErbB1:ErbB3) -> (ErbB1:ErbB3)#P:RTK_Pase k95 kd95
v393 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23
v82 2(ErbB2)#P:GAP:Grb2 + cPP -> 2(ErbB2)#P:GAP:Grb2:cPP k4b kd4
v7 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP)) k2 kd2
v756 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v270 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v453 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37
v340 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v296 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v264 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v417 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v169 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k6 kd6
v682 ErbB2#P + ErbB2:Inh -> ErbB2:ErbB2:Inh k103 kd103
v432 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34
v195 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b
v780 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118
v326 Ras_activated:GTP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v349 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v35 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v587 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
v364 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v509 ERK + (MEK#P#P)_i -> MEK#P#P:ERK k52 kd44
v661 RTK_Pase + 2(ErbB2) -> 2(ErbB2)#P:RTK_Pase k95 kd95
v477 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v124 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v503 MEK + Pase2 -> (MEK#P:Pase2)_i k49 kd49
v226 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v822 (ErbB1:ErbB3)#P + ATP -> (HRG:ErbB3:ErbB1):ATP k123 kd123
v738 (ERK#P#P)_i + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v857 2(EGF:ErbB1_h:ATP) + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k122 kd122
v405 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v670 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) k101 kd101
v95 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v242 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v235 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v692 2(ErbB2)#P:GAP:Grb2 + Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
v367 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22
v54 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v465 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37
v140 cPP + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k5 kd5b
v111 cPP + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k5b kd5b
v3 ErbB2:ErbB4 + EGF -> (ErbB4:ErbB2)#P k1d kd1d