BIOMD0000000255
type: SBMLModel
reaction: 327471
reaction: 328109
parameter: 329201
reaction: 328055
reaction: 326997
parameter: 329179
reaction: 327611
parameter: 329341
reaction: 327785
reaction: 328421
reaction: 328369
reaction: 327523
species: 325998
species: 326094
species: 326301
species: 326649
reaction: 327569
parameter: 328943
parameter: 329053
species: 326357
reaction: 328169
reaction: 327969
reaction: 328489
reaction: 327263
reaction: 328073
reaction: 327637
reaction: 327027
species: 326773
reaction: 328213
species: 326108
rule: 328912
reaction: 327311
reaction: 328533
parameter: 329143
species: 326213
reaction: 328473
species: 326423
reaction: 327571
species: 326701
reaction: 327297
parameter: 329351
species: 326078
reaction: 328521
reaction: 327383
species: 326545
units def: 074830
species: 326223
reaction: 327987
reaction: 327435
reaction: 327341
species: 326817
parameter: 328953
reaction: 328019
reaction: 328593
parameter: 329389
parameter: 329305
parameter: 329025
reaction: 327741
species: 326685
reaction: 327131
reaction: 328551
reaction: 328325
parameter: 329165
reaction: 327685
reaction: 327075
function def: 328925
species: 326869
parameter: 329123
reaction: 327235
reaction: 328045
species: 326203
species: 326917
parameter: 329225
parameter: 329119
reaction: 327861
reaction: 328445
reaction: 327163
parameter: 329195
species: 326325

327471
type: Reaction
kinetic law: 087205
product: 087193
reactant: 087181
reactant: 087169
fast: false
reversible: true
name: v272 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

087193
type: SpeciesReference
stoichiometry: 1.0
species: 326353

326353
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

325906
type: Compartment
is: GO:0010008
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 2.0
name: endosomal membrane

087181
type: SpeciesReference
stoichiometry: 1.0
species: 326355

326355
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos

087169
type: SpeciesReference
stoichiometry: 1.0
species: 326541

326541
type: Species
notes: Ras:GDP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 58095.2
in compartment: 325908
name: Ras:GDP

325908
type: Compartment
is: GO:0005829
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytoplasm

328109
type: Reaction
kinetic law: 101603
product: 101591
reactant: 101579
fast: false
reversible: true
name: v596 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60

101591
type: SpeciesReference
stoichiometry: 1.0
species: 326641

326641
type: Species
notes: R_degraded , lysosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325902
name: R_degraded

325902
type: Compartment
is: GO:0005764
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: lysosomes

101579
type: SpeciesReference
stoichiometry: 1.0
species: 326315

326315
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

329201
type: Parameter
constant: true
value: 0.0
name: k72

328055
type: Reaction
kinetic law: 100629
product: 100617
reactant: 100605
fast: false
reversible: true
name: v567 2(ErbB2)#P:GAP -> R_degraded k60b kd60

100617
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100605
type: SpeciesReference
stoichiometry: 1.0
species: 326483

326483
type: Species
notes: 2(ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP

326997
type: Reaction
kinetic law: 076163
product: 076151
reactant: 076139
reactant: 076127
fast: false
reversible: true
name: v26 EGF:ErbB1:ErbB2 + ATP -> EGF:ErbB1:ErbB2:ATP k122 kd122

076151
type: SpeciesReference
stoichiometry: 1.0
species: 325992

325992
type: Species
notes: EGF:ErbB1:ErbB2:ATP , cytoplasm
boundary condition: false
initial concentration: NaN
in compartment: 325908
initial amount: 0.0
constant: false
name: EGF:ErbB1:ErbB2:ATP
has part: P00533
has version: P01133
has only substance units: true

076139
type: SpeciesReference
stoichiometry: 1.0
species: 325980

325980
type: Species
notes: ATP 1.2e9
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.2E9
in compartment: 325908
name: ATP 1.2e9

076127
type: SpeciesReference
stoichiometry: 1.0
species: 325940

325940
type: Species
name: EGF:ErbB1:ErbB2
is version of: P04626
has only substance units: true
has part: P00533
initial amount: 0.0
boundary condition: false
constant: false
initial concentration: NaN
in compartment: 325898
notes: EGF:ErbB1:ErbB2 , plasma membrane
has version: P01133

325898
type: Compartment
is: GO:0005886
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 2.0
name: plasma membrane

329179
type: Parameter
notes: %PIP2 binds to PI3K
constant: true
value: 5.0E-5
name: k67

327611
type: Reaction
kinetic law: 090628
product: 090616
reactant: 090604
reactant: 090592
fast: false
reversible: true
name: v342 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

090616
type: SpeciesReference
stoichiometry: 1.0
species: 326351

326351
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

090604
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090592
type: SpeciesReference
stoichiometry: 1.0
species: 326355

329341
type: Parameter
constant: true
value: 0.0
name: k113

327785
type: Reaction
kinetic law: 094647
product: 094634
reactant: 094622
reactant: 094610
fast: false
reversible: true
name: v429 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34

094634
type: SpeciesReference
stoichiometry: 1.0
species: 326421

326421
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos

094622
type: SpeciesReference
stoichiometry: 1.0
species: 326577

326577
type: Species
notes: Grb2:Sos , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 8.8914E7
in compartment: 325908
name: Grb2:Sos

094610
type: SpeciesReference
stoichiometry: 1.0
species: 326431

326431
type: Species
notes: 2(EGF:ErbB1)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP

328421
type: Reaction
kinetic law: 108978
product: 108966
reactant: 108954
reactant: 108942
fast: false
reversible: true
name: v752 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112

108966
type: SpeciesReference
stoichiometry: 1.0
species: 326865

326865
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP

108954
type: SpeciesReference
stoichiometry: 1.0
species: 326689

326689
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K

108942
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328369
type: Reaction
kinetic law: 107726
product: 107714
reactant: 107702
reactant: 107690
fast: false
reversible: true
name: v726 (ERK#P#P)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110

107714
type: SpeciesReference
stoichiometry: 1.0
species: 326827

326827
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i

107702
type: SpeciesReference
stoichiometry: 1.0
species: 326687

326687
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P

107690
type: SpeciesReference
stoichiometry: 1.0
species: 326629

326629
type: Species
notes: (ERK#P#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_PP)_i

327523
type: Reaction
kinetic law: 088456
product: 088444
reactant: 088432
reactant: 088420
fast: false
reversible: true
name: v298 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088444
type: SpeciesReference
stoichiometry: 1.0
species: 326393

326393
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

088432
type: SpeciesReference
stoichiometry: 1.0
species: 326545

326545
type: Species
notes: (Ras:GTP)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Ras:GTP)_i

088420
type: SpeciesReference
stoichiometry: 1.0
species: 326399

326399
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos

325998
type: Species
notes: ErbB2:ErbB2#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB2:ErbB2_P

326094
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:cPP

326301
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

326649
type: Species
notes: (HRG:ErbB4:ErbB1) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB4:ErbB1)

327569
type: Reaction
kinetic law: 089587
product: 089574
reactant: 089561
reactant: 089548
fast: false
reversible: true
name: v321 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089574
type: SpeciesReference
stoichiometry: 1.0
species: 326068

326068
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)

089561
type: SpeciesReference
stoichiometry: 1.0
species: 326547

326547
type: Species
notes: Ras_activated:GTP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Ras_activated:GTP

089548
type: SpeciesReference
stoichiometry: 1.0
species: 326060

326060
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos

328943
type: Parameter
constant: true
units: item
value: 905000.0
name: total AKT

329053
type: Parameter
constant: true
value: 1.67E-5
name: k25

326357
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2

328169
type: Reaction
kinetic law: 102906
product: 102894
reactant: 102882
reactant: 102870
fast: false
reversible: true
name: v626 PI3K + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67

102894
type: SpeciesReference
stoichiometry: 1.0
species: 326701

326701
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K

102882
type: SpeciesReference
stoichiometry: 1.0
species: 326699

326699
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P

102870
type: SpeciesReference
stoichiometry: 1.0
species: 326677

326677
type: Species
has only substance units: true
has part: P42336
notes: PI3K , cytoplasm
is version of: REACT 4240.1
boundary condition: false
initial amount: 3.55656E7
has part: P42338
constant: false
name: PI3K
initial concentration: NaN
has part: P27986
has part: O00459
in compartment: 325908

327969
type: Reaction
kinetic law: 099067
product: 099055
reactant: 099042
reactant: 099030
fast: false
reversible: true
name: v521 Pase3 + ERK#P -> ERK#P:Pase3 k58 kd58

099055
type: SpeciesReference
stoichiometry: 1.0
species: 326637

326637
type: Species
notes: ERK#P:Pase3 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_P:Pase3

099042
type: SpeciesReference
stoichiometry: 1.0
species: 326617

326617
type: Species
notes: ERK#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_P

099030
type: SpeciesReference
stoichiometry: 1.0
species: 326631

326631
type: Species
constant: false
is version of: Q16828
has only substance units: true
in compartment: 325908
boundary condition: false
initial amount: 16870.2
notes: Pase3 , cytoplasm
name: Pase3
initial concentration: NaN

328489
type: Reaction
kinetic law: 110604
product: 110592
reactant: 110580
reactant: 110568
fast: false
reversible: true
name: v786 HRG:ErbB3 + ErbB2 -> (HRG:ErbB3):ErbB2 k120 kd120

110592
type: SpeciesReference
stoichiometry: 1.0
species: 326042

326042
type: Species
notes: (HRG:ErbB3):ErbB2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB3):ErbB2

110580
type: SpeciesReference
stoichiometry: 1.0
species: 325938

325938
type: Species
constant: false
in compartment: 325898
initial concentration: NaN
boundary condition: false
has only substance units: true
is version of: P04626
initial amount: 462000.0
notes: ErbB2 , plasma membrane
name: ErbB2

110568
type: SpeciesReference
stoichiometry: 1.0
species: 326903

326903
type: Species
notes: HRG:ErbB3 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: HRG:ErbB3

327263
type: Reaction
kinetic law: 082515
product: 082503
reactant: 082491
fast: false
reversible: true
name: v167 2(EGF:ErbB1)#P:GAP:Shc -> 2(EGF:ErbB1)#P:GAP:Shc k6 kd6

082503
type: SpeciesReference
stoichiometry: 1.0
species: 326435

326435
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Shc

082491
type: SpeciesReference
stoichiometry: 1.0
species: 326433

326433
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Shc

328073
type: Reaction
kinetic law: 100953
product: 100941
reactant: 100929
fast: false
reversible: true
name: v577 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100941
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100929
type: SpeciesReference
stoichiometry: 1.0
species: 326343

326343
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

327637
type: Reaction
kinetic law: 091252
product: 091240
reactant: 091228
reactant: 091216
fast: false
reversible: true
name: v355 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091240
type: SpeciesReference
stoichiometry: 1.0
species: 326197

326197
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)

091228
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091216
type: SpeciesReference
stoichiometry: 1.0
species: 326209

326209
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos

327027
type: Reaction
kinetic law: 076887
product: 076874
reactant: 076862
reactant: 076850
fast: false
reversible: true
name: v41 (HRG:ErbB3):ErbB2) + ATP -> (HRG:ErbB3):ErbB2):ATP k122 kd122

076874
type: SpeciesReference
stoichiometry: 1.0
species: 326048

326048
type: Species
notes: ((HRG:ErbB3):ErbB2):ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ((HRG:ErbB3):ErbB2):ATP

076862
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076850
type: SpeciesReference
stoichiometry: 1.0
species: 326046

326046
type: Species
notes: ((HRG:ErbB3):ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB3):ErbB2)

326773
type: Species
notes: ErbB1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1080000.0
in compartment: 325898
name: ErbB1

328213
type: Reaction
kinetic law: 103964
product: 103952
reactant: 103940
reactant: 103928
fast: false
reversible: true
name: v648 AKT#P + Pase4 -> AKT#P#P:Pase4 k75 kd75

103952
type: SpeciesReference
stoichiometry: 1.0
species: 326751

326751
type: Species
notes: AKT:P:P:Pase4 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P:Pase4

103940
type: SpeciesReference
stoichiometry: 1.0
species: 326749

326749
type: Species
initial concentration: NaN
initial amount: 450000.0
boundary condition: false
is version of: Q13115
has only substance units: true
constant: false
notes: Pase4 , cytoplasm
name: Pase4
in compartment: 325908

103928
type: SpeciesReference
stoichiometry: 1.0
species: 326735

326735
type: Species
notes: AKT#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT_P

326108
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos

327311
type: Reaction
kinetic law: 083383
product: 083371
reactant: 083359
fast: false
reversible: true
name: v191 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP k7 kd7

083371
type: SpeciesReference
stoichiometry: 1.0
species: 326483

083359
type: SpeciesReference
stoichiometry: 1.0
species: 326481

326481
type: Species
notes: 2(ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP

328533
type: Reaction
kinetic law: 111648
product: 111636
reactant: 111624
reactant: 111612
fast: false
reversible: true
name: v809 (ErbB1:ErbB3)#P + ATP -> (EGF:ErbB1:ErbB3):ATP k123 kd123

111636
type: SpeciesReference
stoichiometry: 1.0
species: 325984

325984
type: Species
name: (EGF:ErbB1:ErbB3):ATP
initial concentration: NaN
has version: P01133
has only substance units: true
has part: P00533
boundary condition: false
initial amount: 0.0
constant: false
in compartment: 325908
notes: (EGF:ErbB1:ErbB3):ATP , cytoplasm

111624
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111612
type: SpeciesReference
stoichiometry: 1.0
species: 326467

326467
type: Species
notes: (ErbB1:ErbB3)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P

329143
type: Parameter
constant: false
value: 3.97392E-4
name: k56

326213
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2

328473
type: Reaction
kinetic law: 110219
product: 110207
reactant: 110195
reactant: 110183
fast: false
reversible: true
name: v778 Pase9t + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)2:Gab1#P##:Pase9t k118 kd118

110207
type: SpeciesReference
stoichiometry: 1.0
species: 326889

326889
type: Species
notes: 2(ErbB2)2:Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)2:Gab1_P#:Pase9t

110195
type: SpeciesReference
stoichiometry: 1.0
species: 326695

326695
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P

110183
type: SpeciesReference
stoichiometry: 1.0
species: 326885

326885
type: Species
notes: Pase9t , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Pase9t

326423
type: Species
notes: ErbB1:ATP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB1:ATP

327571
type: Reaction
kinetic law: 089639
product: 089626
reactant: 089613
reactant: 089600
fast: false
reversible: true
name: v322 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089626
type: SpeciesReference
stoichiometry: 1.0
species: 326084

326084
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

089613
type: SpeciesReference
stoichiometry: 1.0
species: 326547

089600
type: SpeciesReference
stoichiometry: 1.0
species: 326076

326076
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos

327297
type: Reaction
kinetic law: 083130
product: 083118
reactant: 083106
fast: false
reversible: true
name: v184 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k6b kd6b

083118
type: SpeciesReference
stoichiometry: 1.0
species: 326459

326459
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P)

083106
type: SpeciesReference
stoichiometry: 1.0
species: 326457

326457
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P)

329351
type: Parameter
constant: true
value: 1.0
name: kd115

326078
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:cPP

328521
type: Reaction
kinetic law: 111360
product: 111348
reactant: 111336
reactant: 111324
fast: false
reversible: true
name: v803 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k123 kd123

111348
type: SpeciesReference
stoichiometry: 1.0
species: 326925

326925
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1:Inh)-HalfActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1:Inh)-HalfActive

111336
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111324
type: SpeciesReference
stoichiometry: 1.0
species: 326425

326425
type: Species
notes: 2(EGF:ErbB1)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P

327383
type: Reaction
kinetic law: 085085
product: 085072
reactant: 085059
reactant: 085047
fast: false
reversible: true
name: v228 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24

085072
type: SpeciesReference
stoichiometry: 1.0
species: 326401

326401
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2

085059
type: SpeciesReference
stoichiometry: 1.0
species: 326537

326537
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P)

085047
type: SpeciesReference
stoichiometry: 1.0
species: 326521

326521
type: Species
initial concentration: NaN
is described by: http://identifiers.org/omim/108355
constant: false
has only substance units: true
name: Grb2
in compartment: 325908
initial amount: 1264.91
notes: Grb2 , cytoplasm
is version of: P62993
boundary condition: false

074842
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

326223
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP

327987
type: Reaction
kinetic law: 099404
product: 099392
reactant: 099380
fast: false
reversible: true
name: v530 2(EGF:ErbB1)#P:GAP:Shc -> R_degraded k60 kd60

099392
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099380
type: SpeciesReference
stoichiometry: 1.0
species: 326435

327435
type: Reaction
kinetic law: 086339
product: 086327
reactant: 086315
reactant: 086303
fast: false
reversible: true
name: v254 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17

086327
type: SpeciesReference
stoichiometry: 1.0
species: 326359

326359
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos

086315
type: SpeciesReference
stoichiometry: 1.0
species: 326377

326377
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2

086303
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326539
type: Species
initial concentration: NaN
is version of: Q07889
notes: Sos , cytoplasm
has only substance units: true
is described by: http://identifiers.org/omim/182530
in compartment: 325908
constant: false
initial amount: 0.0
boundary condition: false
name: Sos

327341
type: Reaction
kinetic law: 084083
product: 084071
reactant: 084059
reactant: 084047
fast: false
reversible: true
name: v206 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8

084071
type: SpeciesReference
stoichiometry: 1.0
species: 326483

084059
type: SpeciesReference
stoichiometry: 1.0
species: 326493

326493
type: Species
is version of: P20936
constant: false
is described by: http://identifiers.org/omim/139150
name: GAP
has only substance units: true
in compartment: 325908
initial amount: 534751.0
notes: GAP , cytoplasm
is version of: IPR001936
boundary condition: false
initial concentration: NaN

084047
type: SpeciesReference
stoichiometry: 1.0
species: 326475

326475
type: Species
notes: 2(ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P

326817
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2

328953
type: Parameter
constant: false
value: 1.0
name: kd1c

328019
type: Reaction
kinetic law: 099980
product: 099968
reactant: 099956
fast: false
reversible: true
name: v547 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

099968
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099956
type: SpeciesReference
stoichiometry: 1.0
species: 326391

326391
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

328593
type: Reaction
kinetic law: 113132
product: 113120
reactant: 113108
reactant: 113096
fast: false
reversible: true
name: v859 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k123 kd123

113120
type: SpeciesReference
stoichiometry: 1.0
species: 326939

326939
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive

113108
type: SpeciesReference
stoichiometry: 1.0
species: 325980

113096
type: SpeciesReference
stoichiometry: 1.0
species: 326425

329389
type: Parameter
constant: true
value: 0.0
name: k6b

329305
type: Parameter
notes: %Gab1 association
constant: true
value: 6.67E-5
name: k105

329025
type: Parameter
constant: true
value: 0.06
name: kd17

327741
type: Reaction
kinetic law: 093584
product: 093572
reactant: 093560
reactant: 093548
fast: false
reversible: true
name: v407 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093572
type: SpeciesReference
stoichiometry: 1.0
species: 326277

326277
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos

093560
type: SpeciesReference
stoichiometry: 1.0
species: 326245

326245
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2

093548
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326685
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K

327131
type: Reaction
kinetic law: 079394
product: 079382
reactant: 079370
reactant: 079357
fast: false
reversible: true
name: v97 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4

079382
type: SpeciesReference
stoichiometry: 1.0
species: 326287

326287
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:cPP

079370
type: SpeciesReference
stoichiometry: 1.0
species: 326056

326056
type: Species
notes: cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 4498.73
in compartment: 325898
name: cPP

079357
type: SpeciesReference
stoichiometry: 1.0
species: 326285

326285
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos

328551
type: Reaction
kinetic law: 112092
product: 112079
reactant: 112066
reactant: 112053
fast: false
reversible: true
name: v818 2(ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123

112079
type: SpeciesReference
stoichiometry: 1.0
species: 326016

326016
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: 2(ErbB2)_P:GAP:Grb2:Gab1:ATP

112066
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112053
type: SpeciesReference
stoichiometry: 1.0
species: 326695

328325
type: Reaction
kinetic law: 106666
product: 106654
reactant: 106642
reactant: 106630
fast: false
reversible: true
name: v704 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k106 kd106

106654
type: SpeciesReference
stoichiometry: 1.0
species: 326725

326725
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)4

106642
type: SpeciesReference
stoichiometry: 1.0
species: 326723

326723
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)3

106630
type: SpeciesReference
stoichiometry: 1.0
species: 326793

326793
type: Species
notes: PIP2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 393639.0
in compartment: 325908
name: PIP2

329165
type: Parameter
constant: true
value: 0.275
name: kd63

327685
type: Reaction
kinetic law: 092407
product: 092395
reactant: 092383
reactant: 092371
fast: false
reversible: true
name: v379 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22

092395
type: SpeciesReference
stoichiometry: 1.0
species: 326445

326445
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Shc

092383
type: SpeciesReference
stoichiometry: 1.0
species: 326509

326509
type: Species
notes: (ErbB4:ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP

092371
type: SpeciesReference
stoichiometry: 1.0
species: 326551

326551
type: Species
boundary condition: false
is version of: P98077
name: Shc
initial amount: 1100000.0
in compartment: 325908
is described by: http://identifiers.org/omim/605217
notes: Shc , cytoplasm
constant: false
has only substance units: true
initial concentration: NaN

327075
type: Reaction
kinetic law: 078045
product: 078033
reactant: 078021
reactant: 078009
fast: false
reversible: true
name: v66 (ErbB1:ErbB4)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k4b kd4

078033
type: SpeciesReference
stoichiometry: 1.0
species: 326146

326146
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:cPP

078021
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078009
type: SpeciesReference
stoichiometry: 1.0
species: 326144

326144
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2

326869
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP

329123
type: Parameter
constant: true
value: 0.112387
name: kd49

327235
type: Reaction
kinetic law: 081901
product: 081889
reactant: 081877
reactant: 081865
fast: false
reversible: true
name: v152 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b

081889
type: SpeciesReference
stoichiometry: 1.0
species: 326094

081877
type: SpeciesReference
stoichiometry: 1.0
species: 326403

326403
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2

081865
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326309
type: Species
notes: cPP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: cPP

328045
type: Reaction
kinetic law: 100449
product: 100437
reactant: 100424
fast: false
reversible: true
name: v560 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100437
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100424
type: SpeciesReference
stoichiometry: 1.0
species: 326365

326365
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)

326203
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:cPP

326917
type: Species
notes: 2(EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1_h:Inh)

329225
type: Parameter
constant: true
value: 0.1
name: kd22b

329119
type: Parameter
constant: false
value: 2.37E-5
name: k48

327861
type: Reaction
kinetic law: 096464
product: 096452
reactant: 096440
reactant: 096428
fast: false
reversible: true
name: v467 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37

096452
type: SpeciesReference
stoichiometry: 1.0
species: 326459

096440
type: SpeciesReference
stoichiometry: 1.0
species: 326523

326523
type: Species
notes: (Shc#P) , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Shc_P)

096428
type: SpeciesReference
stoichiometry: 1.0
species: 326513

326513
type: Species
notes: (ErbB4:ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP

328445
type: Reaction
kinetic law: 109555
product: 109543
reactant: 109531
reactant: 109519
fast: false
reversible: true
name: v764 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113

109543
type: SpeciesReference
stoichiometry: 1.0
species: 326875

326875
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP

109531
type: SpeciesReference
stoichiometry: 1.0
species: 326817

109519
type: SpeciesReference
stoichiometry: 1.0
species: 326543

326543
type: Species
notes: Ras:GTP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Ras:GTP

327163
type: Reaction
kinetic law: 080164
product: 080152
reactant: 080140
reactant: 080128
fast: false
reversible: true
name: v113 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b

080152
type: SpeciesReference
stoichiometry: 1.0
species: 326267

326267
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP

080140
type: SpeciesReference
stoichiometry: 1.0
species: 326331

326331
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

080128
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329195
type: Parameter
constant: true
value: 0.1
name: kd70

326325
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos

327913
type: Reaction
kinetic law: 097717
product: 097705
reactant: 097693
reactant: 097681
fast: false
reversible: true
name: v493 MEK + Raf#P -> MEK:Raf#P k44 kd52

097705
type: SpeciesReference
stoichiometry: 1.0
species: 326593

326593
type: Species
notes: MEK:Raf#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK:Raf_P

097693
type: SpeciesReference
stoichiometry: 1.0
species: 326573

326573
type: Species
notes: Raf#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Raf_P

097681
type: SpeciesReference
stoichiometry: 1.0
species: 326589

326589
type: Species
is version of: A4QPA9
initial concentration: NaN
is version of: Q02750
initial amount: 3020000.0
notes: MEK , cytoplasm
has only substance units: true
name: MEK
in compartment: 325908
boundary condition: false
constant: false
is described by: http://identifiers.org/omim/176872

328933
type: Parameter
constant: false
units: item
value: NaN

326363
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos

328113
type: Reaction
kinetic law: 101675
product: 101663
reactant: 101651
fast: false
reversible: true
name: v598 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60

101663
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101651
type: SpeciesReference
stoichiometry: 1.0
species: 326311

326311
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

327093
type: Reaction
kinetic law: 078478
product: 078466
reactant: 078454
reactant: 078442
fast: false
reversible: true
name: v77 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k4b kd4

078466
type: SpeciesReference
stoichiometry: 1.0
species: 326211

326211
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:cPP

078454
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078442
type: SpeciesReference
stoichiometry: 1.0
species: 326209

328373
type: Reaction
kinetic law: 107822
product: 107810
reactant: 107798
reactant: 107786
fast: false
reversible: true
name: v728 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110

107810
type: SpeciesReference
stoichiometry: 1.0
species: 326831

326831
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:ERK_PP_i

325900
type: Compartment
is: GO:0005768
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: endosomes

107798
type: SpeciesReference
stoichiometry: 1.0
species: 326691

326691
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P

107786
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328929
type: Parameter
constant: false
units: item
value: NaN

329399
type: Parameter
constant: true
value: 0.1
name: kd123h

329039
type: Parameter
constant: true
value: 3.67E-7
name: k21

327253
type: Reaction
kinetic law: 082334
product: 082322
reactant: 082310
reactant: 082298
fast: false
reversible: true
name: v162 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k5 kd5

082322
type: SpeciesReference
stoichiometry: 1.0
species: 326062

326062
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:cPP

082310
type: SpeciesReference
stoichiometry: 1.0
species: 326421

082298
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326114
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP

327347
type: Reaction
kinetic law: 084228
product: 084216
reactant: 084204
reactant: 084192
fast: false
reversible: true
name: v209 ErbB3 + -> (HRG:ErbB3) k10b kd10

084216
type: SpeciesReference
stoichiometry: 1.0
species: 326519

326519
type: Species
notes: (HRG:ErbB3) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB3)

084204
type: SpeciesReference
stoichiometry: 1.0
species: 326517

326517
type: Species
notes: HRG , endosomes
in compartment: 325900
initial amount: 0.0
name: HRG
has only substance units: true
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is version of: Q02297
is version of: IPR018250

084192
type: SpeciesReference
stoichiometry: 1.0
species: 325954

325954
type: Species
notes: ErbB3 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB3

327717
type: Reaction
kinetic law: 093008
product: 092996
reactant: 092984
reactant: 092973
fast: false
reversible: true
name: v395 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

092996
type: SpeciesReference
stoichiometry: 1.0
species: 326076

092984
type: SpeciesReference
stoichiometry: 1.0
species: 326072

326072
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2

092973
type: SpeciesReference
stoichiometry: 1.0
species: 326539

327305
type: Reaction
kinetic law: 083275
product: 083263
reactant: 083251
fast: false
reversible: true
name: v188 2(ErbB2)#P -> 2(ErbB2)#P k7 kd7

083263
type: SpeciesReference
stoichiometry: 1.0
species: 326475

083251
type: SpeciesReference
stoichiometry: 1.0
species: 326473

326473
type: Species
notes: 2(ErbB2)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P

328527
type: Reaction
kinetic law: 111504
product: 111492
reactant: 111480
reactant: 111468
fast: false
reversible: true
name: v806 2(EGF:ErbB1)#P + ATP -> k123 kd123

111492
type: SpeciesReference
stoichiometry: 1.0
species: 326927

326927
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive

111480
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111468
type: SpeciesReference
stoichiometry: 1.0
species: 326425

328097
type: Reaction
kinetic law: 101386
product: 101374
reactant: 101362
fast: false
reversible: true
name: v590 (ErbB3:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60

101374
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101362
type: SpeciesReference
stoichiometry: 1.0
species: 326327

326327
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2

326797
type: Species
notes: PTEN , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 56100.9
in compartment: 325908
name: PTEN

328463
type: Reaction
kinetic law: 109976
product: 109964
reactant: 109952
reactant: 109940
fast: false
reversible: true
name: v773 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117

109964
type: SpeciesReference
stoichiometry: 1.0
species: 326893

326893
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:Pase9t

109952
type: SpeciesReference
stoichiometry: 1.0
species: 326853

326853
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P

109940
type: SpeciesReference
stoichiometry: 1.0
species: 326885

327973
type: Reaction
kinetic law: 099152
product: 099139
reactant: 099127
fast: false
reversible: true
name: v523 ErbB1:ATP -> R_degraded k60 kd60

099139
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099127
type: SpeciesReference
stoichiometry: 1.0
species: 326423

329273
type: Parameter
constant: true
value: 0.001
name: kd98

325926
type: Species
has part: P00533
constant: false
notes: EGF:ErbB1:Inh , plasma membrane
initial amount: 0.0
boundary condition: false
in compartment: 325898
initial concentration: NaN
has only substance units: true
name: EGF:ErbB1:Inh
has version: P01133

327561
type: Reaction
kinetic law: 089378
product: 089365
reactant: 089351
reactant: 089339
fast: false
reversible: true
name: v317 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089365
type: SpeciesReference
stoichiometry: 1.0
species: 326197

089351
type: SpeciesReference
stoichiometry: 1.0
species: 326547

089339
type: SpeciesReference
stoichiometry: 1.0
species: 326209

328557
type: Reaction
kinetic law: 112249
product: 112236
reactant: 112223
reactant: 112210
fast: false
reversible: true
name: v821 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k123 kd123

112236
type: SpeciesReference
stoichiometry: 1.0
species: 326028

326028
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1:ATP

112223
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112210
type: SpeciesReference
stoichiometry: 1.0
species: 326679

326679
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P#)

328173
type: Reaction
kinetic law: 103002
product: 102990
reactant: 102978
reactant: 102966
fast: false
reversible: true
name: v628 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68b

102990
type: SpeciesReference
stoichiometry: 1.0
species: 326709

326709
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2

102978
type: SpeciesReference
stoichiometry: 1.0
species: 326701

102966
type: SpeciesReference
stoichiometry: 1.0
species: 326707

326707
type: Species
has only substance units: true
name: PIP3
is: CHEBI:16618
in compartment: 325908
initial amount: 0.0
boundary condition: false
notes: PIP3 , cytoplasm
initial concentration: NaN
constant: false

326237
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

328515
type: Reaction
kinetic law: 111216
product: 111204
reactant: 111192
fast: false
reversible: true
name: v799 ErbB1_h:ATP + -> ErbB1_h:ATP k6 kd6

111204
type: SpeciesReference
stoichiometry: 1.0
species: 326923

326923
type: Species
notes: ErbB1_h:ATP , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: ErbB1_h:ATP

111192
type: SpeciesReference
stoichiometry: 1.0
species: 326919

326919
type: Species
notes: ErbB1_h:ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1_h:ATP

327641
type: Reaction
kinetic law: 091348
product: 091336
reactant: 091324
reactant: 091312
fast: false
reversible: true
name: v357 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091336
type: SpeciesReference
stoichiometry: 1.0
species: 326367

326367
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)

091324
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091312
type: SpeciesReference
stoichiometry: 1.0
species: 326361

326361
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos

327031
type: Reaction
kinetic law: 076983
product: 076971
reactant: 076959
reactant: 076947
fast: false
reversible: true
name: v43 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k4 kd4

076971
type: SpeciesReference
stoichiometry: 1.0
species: 326058

326058
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:cPP

076959
type: SpeciesReference
stoichiometry: 1.0
species: 326056

076947
type: SpeciesReference
stoichiometry: 1.0
species: 326054

326054
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2

329129
type: Parameter
constant: true
value: 0.252982
name: kd50

328225
type: Reaction
kinetic law: 104252
product: 104240
reactant: 104228
reactant: 104216
fast: false
reversible: true
name: v654 RTK_Pase + (ErbB3:ErbB2)#P -> (ErbB2:ErbB3)#P:RTK_Pase k94 kd94

104240
type: SpeciesReference
stoichiometry: 1.0
species: 326765

326765
type: Species
notes: (ErbB2:ErbB3)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB2:ErbB3)_P:RTK_Pase

104228
type: SpeciesReference
stoichiometry: 1.0
species: 326477

326477
type: Species
notes: (ErbB3:ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P

104216
type: SpeciesReference
stoichiometry: 1.0
species: 326755

326755
type: Species
notes: RTK_Pase , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 70000.0
in compartment: 325908
name: RTK_Pase

326721
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)2

328161
type: Reaction
kinetic law: 102712
product: 102700
reactant: 102688
reactant: 102676
fast: false
reversible: true
name: v622 PI3K + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66

102700
type: SpeciesReference
stoichiometry: 1.0
species: 326685

102688
type: SpeciesReference
stoichiometry: 1.0
species: 326683

326683
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P

102676
type: SpeciesReference
stoichiometry: 1.0
species: 326677

328009
type: Reaction
kinetic law: 099800
product: 099788
reactant: 099776
fast: false
reversible: true
name: v542 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60

099788
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099776
type: SpeciesReference
stoichiometry: 1.0
species: 326401

326247
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:cPP

326653
type: Species
notes: (ErbB4:ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)

327365
type: Reaction
kinetic law: 084650
product: 084638
reactant: 084626
reactant: 084613
fast: false
reversible: true
name: v219 Grb2 + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24

084638
type: SpeciesReference
stoichiometry: 1.0
species: 326144

084626
type: SpeciesReference
stoichiometry: 1.0
species: 326505

326505
type: Species
notes: (ErbB1:ErbB4)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP

084613
type: SpeciesReference
stoichiometry: 1.0
species: 326521

327121
type: Reaction
kinetic law: 079152
product: 079140
reactant: 079128
reactant: 079116
fast: false
reversible: true
name: v92 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4

079140
type: SpeciesReference
stoichiometry: 1.0
species: 326267

079128
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079116
type: SpeciesReference
stoichiometry: 1.0
species: 326265

326265
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

326571
type: Species
notes: (Raf#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Raf_P)_i

327825
type: Reaction
kinetic law: 095597
product: 095585
reactant: 095573
reactant: 095561
fast: false
reversible: true
name: v449 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37

095585
type: SpeciesReference
stoichiometry: 1.0
species: 326529

326529
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P)

095573
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095561
type: SpeciesReference
stoichiometry: 1.0
species: 326503

326503
type: Species
notes: (ErbB1:ErbB3)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP

327991
type: Reaction
kinetic law: 099476
product: 099464
reactant: 099452
fast: false
reversible: true
name: v532 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> R_degraded k60 kd60

099464
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099452
type: SpeciesReference
stoichiometry: 1.0
species: 326413

326413
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2

329049
type: Parameter
constant: true
value: 0.06
name: kd23

328575
type: Reaction
kinetic law: 112699
product: 112687
reactant: 112674
reactant: 112662
fast: false
reversible: true
name: v850 EGF:ErbB1:ATP + EGF:ErbB1_h:ATP -> EGF:ErbB1:ATP::EGF:ErbB1_h:ATP k2 kd2

112687
type: SpeciesReference
stoichiometry: 1.0
species: 326929

326929
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)

112674
type: SpeciesReference
stoichiometry: 1.0
species: 326921

326921
type: Species
notes: EGF:ErbB1_h:ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: EGF:ErbB1_h:ATP

112662
type: SpeciesReference
stoichiometry: 1.0
species: 325914

325914
type: Species
is: SBO:0000297
initial amount: 0.0
name: EGF:ErbB1:ATP
initial concentration: NaN
notes: EGF:ErbB1:ATP , plasma membrane
has part: CHEBI:15422
has only substance units: true
constant: false
has version: P01133
in compartment: 325898
has part: P00533
boundary condition: false

328349
type: Reaction
kinetic law: 107243
product: 107231
reactant: 107219
reactant: 107207
fast: false
reversible: true
name: v716 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108

107231
type: SpeciesReference
stoichiometry: 1.0
species: 326811

326811
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:Shp2

107219
type: SpeciesReference
stoichiometry: 1.0
species: 326010

326010
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1

107207
type: SpeciesReference
stoichiometry: 1.0
species: 326805

326805
type: Species
initial concentration: NaN
in compartment: 325908
is version of: Q06124
constant: false
boundary condition: false
name: Shp2
initial amount: 1000000.0
notes: Shp2 , cytoplasm
has only substance units: true

329291
type: Parameter
constant: true
value: 0.03
name: kd101

328191
type: Reaction
kinetic law: 103435
product: 103423
reactant: 103411
reactant: 103399
fast: false
reversible: true
name: v637 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k68 kd68b

103423
type: SpeciesReference
stoichiometry: 1.0
species: 326727

326727
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)5

103411
type: SpeciesReference
stoichiometry: 1.0
species: 326725

103399
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327229
type: Reaction
kinetic law: 081757
product: 081745
reactant: 081733
reactant: 081720
fast: false
reversible: true
name: v149 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b

081745
type: SpeciesReference
stoichiometry: 1.0
species: 326106

326106
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:cPP

081733
type: SpeciesReference
stoichiometry: 1.0
species: 326397

326397
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos

081720
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329147
type: Parameter
constant: true
value: 0.0
name: k57

326965
type: Reaction
kinetic law: 075362
product: 075350
reactant: 075337
reactant: 075325
fast: false
reversible: true
name: v10 EGF:ErbB1:ATP + ErbB3 -> EGF:ErbB1:ErbB3 k2b kd2b

075350
type: SpeciesReference
stoichiometry: 1.0
species: 325944

325944
type: Species
initial concentration: NaN
in compartment: 325898
has part: P00533
has version: P01133
has only substance units: true
notes: EGF:ErbB1:ErbB3 , plasma membrane
name: EGF:ErbB1:ErbB3
boundary condition: false
constant: false
initial amount: 0.0

075337
type: SpeciesReference
stoichiometry: 1.0
species: 325942

325942
type: Species
notes: ErbB3 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 6230.0
in compartment: 325898
name: ErbB3

075325
type: SpeciesReference
stoichiometry: 1.0
species: 325914

327485
type: Reaction
kinetic law: 087542
product: 087530
reactant: 087518
reactant: 087506
fast: false
reversible: true
name: v279 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087530
type: SpeciesReference
stoichiometry: 1.0
species: 326297

326297
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

087518
type: SpeciesReference
stoichiometry: 1.0
species: 326289

326289
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos

087506
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327259
type: Reaction
kinetic law: 082443
product: 082431
reactant: 082419
fast: false
reversible: true
name: v165 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P k6 kd6

082431
type: SpeciesReference
stoichiometry: 1.0
species: 326427

326427
type: Species
notes: 2(EGF:ErbB1)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P

082419
type: SpeciesReference
stoichiometry: 1.0
species: 326425

325916
type: Species
is: SBO:0000297
has only substance units: true
initial amount: 0.0
name: (ErbB2:ErbB3)
has part: P04626
boundary condition: false
has part: P21860
notes: (ErbB2:ErbB3) , plasma membrane
constant: false
initial concentration: NaN
in compartment: 325898

328069
type: Reaction
kinetic law: 100880
product: 100868
reactant: 100856
fast: false
reversible: true
name: v575 2(ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60

100868
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100856
type: SpeciesReference
stoichiometry: 1.0
species: 326347

326347
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2:Sos

329287
type: Parameter
constant: true
value: 1.0
name: k100

328439
type: Reaction
kinetic law: 109411
product: 109399
reactant: 109387
reactant: 109375
fast: false
reversible: true
name: v761 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113

109399
type: SpeciesReference
stoichiometry: 1.0
species: 326869

109387
type: SpeciesReference
stoichiometry: 1.0
species: 326685

109375
type: SpeciesReference
stoichiometry: 1.0
species: 326543

329355
type: Parameter
constant: true
value: 0.0
name: kd116

326227
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP

328273
type: Reaction
kinetic law: 105412
product: 105400
reactant: 105388
reactant: 105376
fast: false
reversible: true
name: v678 ErbB2 + ErbB3 -> (ErbB2:ErbB3) k103 kd103

105400
type: SpeciesReference
stoichiometry: 1.0
species: 325916

105388
type: SpeciesReference
stoichiometry: 1.0
species: 325942

105376
type: SpeciesReference
stoichiometry: 1.0
species: 325938

327949
type: Reaction
kinetic law: 098585
product: 098573
reactant: 098561
reactant: 098549
fast: false
reversible: true
name: v511 (ERK#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK k53 kd53

098573
type: SpeciesReference
stoichiometry: 1.0
species: 326621

326621
type: Species
notes: MEK#P#P:ERK , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP:ERK

098561
type: SpeciesReference
stoichiometry: 1.0
species: 326601

326601
type: Species
notes: (MEK#P#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_PP)_i

098549
type: SpeciesReference
stoichiometry: 1.0
species: 326623

326623
type: Species
notes: (ERK#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_P)_i

327537
type: Reaction
kinetic law: 088796
product: 088784
reactant: 088771
reactant: 088759
fast: false
reversible: true
name: v305 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088784
type: SpeciesReference
stoichiometry: 1.0
species: 326373

326373
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)

088771
type: SpeciesReference
stoichiometry: 1.0
species: 326545

088759
type: SpeciesReference
stoichiometry: 1.0
species: 326361

326715
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2

327885
type: Reaction
kinetic law: 097041
product: 097029
reactant: 097017
reactant: 097005
fast: false
reversible: true
name: v479 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097029
type: SpeciesReference
stoichiometry: 1.0
species: 326397

097017
type: SpeciesReference
stoichiometry: 1.0
species: 326535

326535
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P)

097005
type: SpeciesReference
stoichiometry: 1.0
species: 326577

326711
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2

328469
type: Reaction
kinetic law: 110123
product: 110111
reactant: 110098
reactant: 110086
fast: false
reversible: true
name: v776 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k117 kd117

110111
type: SpeciesReference
stoichiometry: 1.0
species: 326899

326899
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:_PP:Pase9t

110098
type: SpeciesReference
stoichiometry: 1.0
species: 326861

326861
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:_PP

110086
type: SpeciesReference
stoichiometry: 1.0
species: 326885

326349
type: Species
notes: 2(ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2

329021
type: Parameter
constant: true
value: 1.667E-7
name: k16b

327937
type: Reaction
kinetic law: 098296
product: 098284
reactant: 098272
reactant: 098260
fast: false
reversible: true
name: v505 Pase2 + (MEK#P)_i -> (MEK#P:Pase2)_i k50 kd50

098284
type: SpeciesReference
stoichiometry: 1.0
species: 326611

326611
type: Species
notes: (MEK#P:Pase2)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_P:Pase2)_i

098272
type: SpeciesReference
stoichiometry: 1.0
species: 326585

326585
type: Species
notes: (MEK#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_P)_i

098260
type: SpeciesReference
stoichiometry: 1.0
species: 326603

326603
type: Species
in compartment: 325908
boundary condition: false
initial amount: 124480.0
notes: Pase2 , cytoplasm
is version of: Q13115
name: Pase2
initial concentration: NaN
constant: false
has only substance units: true

328957
type: Parameter
constant: false
value: 518.0
name: k1d

326387
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

327617
type: Reaction
kinetic law: 090772
product: 090760
reactant: 090748
reactant: 090736
fast: false
reversible: true
name: v345 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

090760
type: SpeciesReference
stoichiometry: 1.0
species: 326084

090748
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090736
type: SpeciesReference
stoichiometry: 1.0
species: 326076

327007
type: Reaction
kinetic law: 076403
product: 076391
reactant: 076379
reactant: 076367
fast: false
reversible: true
name: v31 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k122 kd122

076391
type: SpeciesReference
stoichiometry: 1.0
species: 326008

326008
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1:ATP

076379
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076367
type: SpeciesReference
stoichiometry: 1.0
species: 326006

326006
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1

328137
type: Reaction
kinetic law: 102134
product: 102122
reactant: 102110
reactant: 102098
fast: false
reversible: true
name: v610 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64

102122
type: SpeciesReference
stoichiometry: 1.0
species: 326657

326657
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(ERK_PP)

102110
type: SpeciesReference
stoichiometry: 1.0
species: 326421

102098
type: SpeciesReference
stoichiometry: 1.0
species: 326629

326643
type: Species
notes: 2(ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)

329309
type: Parameter
constant: true
value: 1.33E-5
name: k106

328041
type: Reaction
kinetic law: 100376
product: 100364
reactant: 100352
fast: false
reversible: true
name: v558 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100364
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100352
type: SpeciesReference
stoichiometry: 1.0
species: 326369

326369
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

074769
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND

328501
type: Reaction
kinetic law: 110892
product: 110880
reactant: 110868
reactant: 110856
fast: false
reversible: true
name: v792 ErbB1:ATP + (HRG:ErbB3) -> (HRG:ErbB3:ErbB1) k120b kd120

110880
type: SpeciesReference
stoichiometry: 1.0
species: 326647

326647
type: Species
notes: (HRG:ErbB3:ErbB1) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB3:ErbB1)

110868
type: SpeciesReference
stoichiometry: 1.0
species: 326519

110856
type: SpeciesReference
stoichiometry: 1.0
species: 326423

327277
type: Reaction
kinetic law: 082767
product: 082755
reactant: 082743
fast: false
reversible: true
name: v174 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k6 kd6

082755
type: SpeciesReference
stoichiometry: 1.0
species: 326407

326407
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

082743
type: SpeciesReference
stoichiometry: 1.0
species: 326084

327597
type: Reaction
kinetic law: 090288
product: 090276
reactant: 090264
reactant: 090252
fast: false
reversible: true
name: v335 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

090276
type: SpeciesReference
stoichiometry: 1.0
species: 326305

326305
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

090264
type: SpeciesReference
stoichiometry: 1.0
species: 326547

090252
type: SpeciesReference
stoichiometry: 1.0
species: 326289

328291
type: Reaction
kinetic law: 105847
product: 105835
reactant: 105822
reactant: 105810
fast: false
reversible: true
name: v687 PTEN + PIP2 -> PIP3:PTEN k104 kd104

105835
type: SpeciesReference
stoichiometry: 1.0
species: 326799

326799
type: Species
notes: PIP3:PTEN , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:PTEN

105822
type: SpeciesReference
stoichiometry: 1.0
species: 326793

105810
type: SpeciesReference
stoichiometry: 1.0
species: 326797

327997
type: Reaction
kinetic law: 099584
product: 099572
reactant: 099560
fast: false
reversible: true
name: v535 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + -> R_degraded k60 kd60

099572
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099560
type: SpeciesReference
stoichiometry: 1.0
species: 326407

074818
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

327585
type: Reaction
kinetic law: 089998
product: 089986
reactant: 089974
reactant: 089962
fast: false
reversible: true
name: v329 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089986
type: SpeciesReference
stoichiometry: 1.0
species: 326385

326385
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

089974
type: SpeciesReference
stoichiometry: 1.0
species: 326397

089962
type: SpeciesReference
stoichiometry: 1.0
species: 326549

326549
type: Species
notes: (Ras_activated:GTP)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Ras_activated:GTP)_i

326877
type: Species
notes: AKT:P:P:Raf:P:Ser , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P:Raf:P:Ser

328197
type: Reaction
kinetic law: 103580
product: 103568
reactant: 103555
reactant: 103543
fast: false
reversible: true
name: v640 PIP3 + AKT#P -> PIP3:AKT#P k69 kd69

103568
type: SpeciesReference
stoichiometry: 1.0
species: 326737

326737
type: Species
notes: PIP3:AKT#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT_P

103555
type: SpeciesReference
stoichiometry: 1.0
species: 326735

103543
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327351
type: Reaction
kinetic law: 084312
product: 084300
reactant: 084288
reactant: 084276
fast: false
reversible: true
name: v212 Grb2 + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63

084300
type: SpeciesReference
stoichiometry: 1.0
species: 326054

084288
type: SpeciesReference
stoichiometry: 1.0
species: 326429

326429
type: Species
notes: 2(EGF:ErbB1)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP

084276
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328155
type: Reaction
kinetic law: 102567
product: 102555
reactant: 102543
reactant: 102531
fast: false
reversible: true
name: v619 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k65 kd65

102555
type: SpeciesReference
stoichiometry: 1.0
species: 326661

326661
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(ERK_PP)

102543
type: SpeciesReference
stoichiometry: 1.0
species: 326675

326675
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:(Sos_P)

102531
type: SpeciesReference
stoichiometry: 1.0
species: 326629

329259
type: Parameter
notes: %low affinity Iressa
constant: true
value: 3.5E-8
name: KD_iressa_wt

328305
type: Reaction
kinetic law: 106184
product: 106172
reactant: 106160
reactant: 106148
fast: false
reversible: true
name: v694 (ErbB4:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105

106172
type: SpeciesReference
stoichiometry: 1.0
species: 326022

326022
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1

106160
type: SpeciesReference
stoichiometry: 1.0
species: 326801

326801
type: Species
notes: Gab1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 94868.3
in compartment: 325908
name: Gab1

106148
type: SpeciesReference
stoichiometry: 1.0
species: 326281

326281
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2

327665
type: Reaction
kinetic law: 091926
product: 091914
reactant: 091902
reactant: 091890
fast: false
reversible: true
name: v369 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b

091914
type: SpeciesReference
stoichiometry: 1.0
species: 326553

326553
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Shc

091902
type: SpeciesReference
stoichiometry: 1.0
species: 326501

326501
type: Species
notes: (ErbB1:ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP

091890
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327955
type: Reaction
kinetic law: 098729
product: 098717
reactant: 098705
reactant: 098693
fast: false
reversible: true
name: v514 (ERK#P#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK#P k55 kd55

098717
type: SpeciesReference
stoichiometry: 1.0
species: 326625

326625
type: Species
notes: MEK#P#P:ERK#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP:ERK_P

098705
type: SpeciesReference
stoichiometry: 1.0
species: 326601

098693
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328249
type: Reaction
kinetic law: 104833
product: 104821
reactant: 104809
reactant: 104797
fast: false
reversible: true
name: v666 ErbB2 + Inh -> ErbB2:Inh k98 kd98

104821
type: SpeciesReference
stoichiometry: 1.0
species: 325968

325968
type: Species
notes: ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB2:Inh

104809
type: SpeciesReference
stoichiometry: 1.0
species: 326775

326775
type: Species
constant: false
notes: Inh , medium
name: Inh
initial amount: NaN
has only substance units: false
is version of: CHEBI:49603
in compartment: 325904
initial concentration: 0.0
substance units: mole
boundary condition: true
is version of: GO:0030293

325904
type: Compartment
is: GO:0005615
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: medium

104797
type: SpeciesReference
stoichiometry: 1.0
species: 325938

327403
type: Reaction
kinetic law: 085567
product: 085555
reactant: 085543
reactant: 085530
fast: false
reversible: true
name: v238 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd24

085555
type: SpeciesReference
stoichiometry: 1.0
species: 326327

085543
type: SpeciesReference
stoichiometry: 1.0
species: 326521

085530
type: SpeciesReference
stoichiometry: 1.0
species: 326511

326511
type: Species
notes: (ErbB3:ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP

327891
type: Reaction
kinetic law: 097187
product: 097175
reactant: 097162
reactant: 097150
fast: false
reversible: true
name: v482 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097175
type: SpeciesReference
stoichiometry: 1.0
species: 326355

097162
type: SpeciesReference
stoichiometry: 1.0
species: 326491

326491
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P)

097150
type: SpeciesReference
stoichiometry: 1.0
species: 326577

326339
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2

328561
type: Reaction
kinetic law: 112353
product: 112340
reactant: 112327
reactant: 112314
fast: false
reversible: true
name: v823 (ErbB1:ErbB4)#P + ATP -> (HRG:ErbB4:ErbB1):ATP k123 kd123

112340
type: SpeciesReference
stoichiometry: 1.0
species: 326036

326036
type: Species
notes: (HRG:ErbB4:ErbB1):ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (HRG:ErbB4:ErbB1):ATP

112327
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112314
type: SpeciesReference
stoichiometry: 1.0
species: 326469

326469
type: Species
notes: (ErbB1:ErbB4)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P

327449
type: Reaction
kinetic law: 086676
product: 086664
reactant: 086652
reactant: 086640
fast: false
reversible: true
name: v261 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086664
type: SpeciesReference
stoichiometry: 1.0
species: 326120

326120
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

086652
type: SpeciesReference
stoichiometry: 1.0
species: 326108

086640
type: SpeciesReference
stoichiometry: 1.0
species: 326541

325952
type: Species
notes: (EGF:ErbB1:ErbB2) , endosomal membrane
initial concentration: NaN
in compartment: 325906
has part: P00533
has only substance units: true
constant: false
name: (EGF:ErbB1:ErbB2)
initial amount: 0.0
boundary condition: false
has version: P01133

326118
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP

329319
type: Parameter
constant: true
value: 0.1
name: kd107

327819
type: Reaction
kinetic law: 095453
product: 095441
reactant: 095429
reactant: 095417
fast: false
reversible: true
name: v446 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37

095441
type: SpeciesReference
stoichiometry: 1.0
species: 326439

326439
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P)

095429
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095417
type: SpeciesReference
stoichiometry: 1.0
species: 326431

327389
type: Reaction
kinetic law: 085229
product: 085217
reactant: 085205
reactant: 085193
fast: false
reversible: true
name: v231 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63

085217
type: SpeciesReference
stoichiometry: 1.0
species: 326229

326229
type: Species
notes: 2(ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2

085205
type: SpeciesReference
stoichiometry: 1.0
species: 326521

085193
type: SpeciesReference
stoichiometry: 1.0
species: 326481

327145
type: Reaction
kinetic law: 079732
product: 079720
reactant: 079708
reactant: 079696
fast: false
reversible: true
name: v104 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b

079720
type: SpeciesReference
stoichiometry: 1.0
species: 326303

326303
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP

079708
type: SpeciesReference
stoichiometry: 1.0
species: 326313

326313
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

079696
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328339
type: Reaction
kinetic law: 107003
product: 106991
reactant: 106979
reactant: 106966
fast: false
reversible: true
name: v711 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107

106991
type: SpeciesReference
stoichiometry: 1.0
species: 326815

326815
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2

106979
type: SpeciesReference
stoichiometry: 1.0
species: 326699

106966
type: SpeciesReference
stoichiometry: 1.0
species: 326805

326595
type: Species
notes: MEK#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_P

328013
type: Reaction
kinetic law: 099872
product: 099860
reactant: 099848
fast: false
reversible: true
name: v544 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60

099860
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099848
type: SpeciesReference
stoichiometry: 1.0
species: 326397

327089
type: Reaction
kinetic law: 078382
product: 078370
reactant: 078358
reactant: 078346
fast: false
reversible: true
name: v75 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4

078370
type: SpeciesReference
stoichiometry: 1.0
species: 326203

078358
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078346
type: SpeciesReference
stoichiometry: 1.0
species: 326201

326201
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos

327849
type: Reaction
kinetic law: 096174
product: 096162
reactant: 096150
reactant: 096138
fast: false
reversible: true
name: v461 2(ErbB2)#P:GAP + (Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k37 kd37

096162
type: SpeciesReference
stoichiometry: 1.0
species: 326491

096150
type: SpeciesReference
stoichiometry: 1.0
species: 326523

096138
type: SpeciesReference
stoichiometry: 1.0
species: 326483

327203
type: Reaction
kinetic law: 081125
product: 081113
reactant: 081101
reactant: 081089
fast: false
reversible: true
name: v136 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b

081113
type: SpeciesReference
stoichiometry: 1.0
species: 326158

326158
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP):cPP

081101
type: SpeciesReference
stoichiometry: 1.0
species: 326371

326371
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)

081089
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326000
type: Species
notes: ErbB2:ErbB2#P:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ErbB2:ErbB2_P:ATP

328599
type: Reaction
kinetic law: 113275
product: 113263
reactant: 113251
reactant: 113239
fast: false
reversible: true
name: v862 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k123h kd123h

113263
type: SpeciesReference
stoichiometry: 1.0
species: 326945

326945
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive

113251
type: SpeciesReference
stoichiometry: 1.0
species: 325980

113239
type: SpeciesReference
stoichiometry: 1.0
species: 326425

326909
type: Species
notes: ErbB1_h , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1_h

326233
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos

327777
type: Reaction
kinetic law: 094453
product: 094441
reactant: 094429
reactant: 094417
fast: false
reversible: true
name: v425 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094441
type: SpeciesReference
stoichiometry: 1.0
species: 326253

326253
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos

094429
type: SpeciesReference
stoichiometry: 1.0
species: 326575

326575
type: Species
notes: (Shc#P):Grb2:Sos , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Shc_P):Grb2:Sos

094417
type: SpeciesReference
stoichiometry: 1.0
species: 326509

326989
type: Reaction
kinetic law: 075970
product: 075958
reactant: 075946
reactant: 075934
fast: false
reversible: true
name: v22 (EGF:ErbB1:ErbB3) + ATP -> (EGF:ErbB1:ErbB3):ATP k122 kd122

075958
type: SpeciesReference
stoichiometry: 1.0
species: 325984

075946
type: SpeciesReference
stoichiometry: 1.0
species: 325980

075934
type: SpeciesReference
stoichiometry: 1.0
species: 325956

325956
type: Species
has part: P00533
in compartment: 325906
initial amount: 0.0
has only substance units: true
initial concentration: NaN
boundary condition: false
constant: false
name: (EGF:ErbB1:ErbB3)
has version: P01133
notes: (EGF:ErbB1:ErbB3) , endosomal membrane

326018
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1

328413
type: Reaction
kinetic law: 108784
product: 108772
reactant: 108760
reactant: 108748
fast: false
reversible: true
name: v748 (ERK#P#P)_i + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k111 kd111

108772
type: SpeciesReference
stoichiometry: 1.0
species: 326823

326823
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):ERK_PP_i

108760
type: SpeciesReference
stoichiometry: 1.0
species: 326859

326859
type: Species
notes: 2(EGF:ErbB1):Gab1#P## , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1):Gab1_P#

108748
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328297
type: Reaction
kinetic law: 105991
product: 105979
reactant: 105967
reactant: 105955
fast: false
reversible: true
name: v690 (ErbB1:ErbB3)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 k105 kd105

105979
type: SpeciesReference
stoichiometry: 1.0
species: 326006

105967
type: SpeciesReference
stoichiometry: 1.0
species: 326801

105955
type: SpeciesReference
stoichiometry: 1.0
species: 326140

326140
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2

327177
type: Reaction
kinetic law: 080500
product: 080488
reactant: 080476
reactant: 080464
fast: false
reversible: true
name: v121 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b

080488
type: SpeciesReference
stoichiometry: 1.0
species: 326239

326239
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP

080476
type: SpeciesReference
stoichiometry: 1.0
species: 326345

326345
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

080464
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326739
type: Species
has only substance units: true
initial amount: 3.00416E8
name: PDK1
in compartment: 325908
boundary condition: false
is version of: O15530
initial concentration: NaN
notes: PDK1 , cytoplasm
constant: false

329151
type: Parameter
constant: false
value: 56.7862
name: kd58

326911
type: Species
notes: ErbB1_h:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1_h:Inh

327061
type: Reaction
kinetic law: 077707
product: 077695
reactant: 077683
reactant: 077671
fast: false
reversible: true
name: v59 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4

077695
type: SpeciesReference
stoichiometry: 1.0
species: 326118

077683
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077671
type: SpeciesReference
stoichiometry: 1.0
species: 326116

326116
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

329045
type: Parameter
constant: true
value: 0.1
name: kd22

327867
type: Reaction
kinetic law: 096608
product: 096596
reactant: 096584
reactant: 096572
fast: false
reversible: true
name: v470 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

096596
type: SpeciesReference
stoichiometry: 1.0
species: 326249

326249
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2

096584
type: SpeciesReference
stoichiometry: 1.0
species: 326525

326525
type: Species
notes: (Shc#P):Grb2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Shc_P):Grb2

096572
type: SpeciesReference
stoichiometry: 1.0
species: 326509

328387
type: Reaction
kinetic law: 108158
product: 108146
reactant: 108134
reactant: 108122
fast: false
reversible: true
name: v735 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110

108146
type: SpeciesReference
stoichiometry: 1.0
species: 326845

326845
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP

108134
type: SpeciesReference
stoichiometry: 1.0
species: 326703

326703
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P

108122
type: SpeciesReference
stoichiometry: 1.0
species: 326627

326627
type: Species
notes: ERK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_PP

327315
type: Reaction
kinetic law: 083455
product: 083443
reactant: 083431
fast: false
reversible: true
name: v193 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k7 kd7

083443
type: SpeciesReference
stoichiometry: 1.0
species: 326491

083431
type: SpeciesReference
stoichiometry: 1.0
species: 326489

326489
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P)

328973
type: Parameter
constant: true
value: 1.66E-4
name: kd4

327221
type: Reaction
kinetic law: 081562
product: 081550
reactant: 081537
reactant: 081525
fast: false
reversible: true
name: v145 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b

081550
type: SpeciesReference
stoichiometry: 1.0
species: 326122

326122
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP

081537
type: SpeciesReference
stoichiometry: 1.0
species: 326389

326389
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

081525
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326667
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos_P

327897
type: Reaction
kinetic law: 097333
product: 097321
reactant: 097308
reactant: 097296
fast: false
reversible: true
name: v485 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097321
type: SpeciesReference
stoichiometry: 1.0
species: 326253

097308
type: SpeciesReference
stoichiometry: 1.0
species: 326457

097296
type: SpeciesReference
stoichiometry: 1.0
species: 326577

329083
type: Parameter
constant: false
value: 7.5E-6
name: k35

327919
type: Reaction
kinetic law: 097862
product: 097850
reactant: 097838
reactant: 097826
fast: false
reversible: true
name: v496 (MEK#P)_i + (Raf#P)_i -> (MEK:Raf#P)_i k45 kd45

097850
type: SpeciesReference
stoichiometry: 1.0
species: 326591

326591
type: Species
notes: (MEK:Raf#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK:Raf_P)_i

097838
type: SpeciesReference
stoichiometry: 1.0
species: 326571

097826
type: SpeciesReference
stoichiometry: 1.0
species: 326585

327481
type: Reaction
kinetic law: 087446
product: 087434
reactant: 087422
reactant: 087410
fast: false
reversible: true
name: v277 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

087434
type: SpeciesReference
stoichiometry: 1.0
species: 326257

326257
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

087422
type: SpeciesReference
stoichiometry: 1.0
species: 326277

087410
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328119
type: Reaction
kinetic law: 101785
product: 101772
reactant: 101760
fast: false
reversible: true
name: v601 (EGF:ErbB1:ErbB3) -> R_degraded k62b kd60b

101772
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101760
type: SpeciesReference
stoichiometry: 1.0
species: 325956

328065
type: Reaction
kinetic law: 100808
product: 100796
reactant: 100784
fast: false
reversible: true
name: v573 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100796
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100784
type: SpeciesReference
stoichiometry: 1.0
species: 326351

327621
type: Reaction
kinetic law: 090868
product: 090856
reactant: 090844
reactant: 090832
fast: false
reversible: true
name: v347 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

090856
type: SpeciesReference
stoichiometry: 1.0
species: 326124

326124
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

090844
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090832
type: SpeciesReference
stoichiometry: 1.0
species: 326100

326100
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos

328431
type: Reaction
kinetic law: 109219
product: 109206
reactant: 109194
reactant: 109182
fast: false
reversible: true
name: v757 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112

109206
type: SpeciesReference
stoichiometry: 1.0
species: 326875

109194
type: SpeciesReference
stoichiometry: 1.0
species: 326705

326705
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K

109182
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328205
type: Reaction
kinetic law: 103772
product: 103760
reactant: 103748
reactant: 103736
fast: false
reversible: true
name: v644 AKT#P#P + PIP3:PDK1 -> PIP3:AKT#P:PDK1 k72 kd72

103760
type: SpeciesReference
stoichiometry: 1.0
species: 326741

326741
type: Species
notes: PIP3:AKT#P:PDK1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT_P:PDK1

103748
type: SpeciesReference
stoichiometry: 1.0
species: 326745

326745
type: Species
notes: PIP3:PDK1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:PDK1

103736
type: SpeciesReference
stoichiometry: 1.0
species: 326747

326747
type: Species
notes: AKT:P:P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P

329241
type: Parameter
constant: true
value: 1.67E-6
name: k96

327941
type: Reaction
kinetic law: 098392
product: 098380
reactant: 098368
reactant: 098356
fast: false
reversible: true
name: v507 ERK + MEK#P#P -> ERK:MEK#P#P k52 kd44

098380
type: SpeciesReference
stoichiometry: 1.0
species: 326615

326615
type: Species
notes: ERK:MEK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK:MEK_PP

098368
type: SpeciesReference
stoichiometry: 1.0
species: 326599

326599
type: Species
notes: MEK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP

098356
type: SpeciesReference
stoichiometry: 1.0
species: 326613

326613
type: Species
has only substance units: true
in compartment: 325908
constant: false
is described by: http://identifiers.org/omim/176948
initial concentration: NaN
initial amount: 695000.0
notes: ERK , cytoplasm
boundary condition: false
name: ERK
is version of: P28482

327289
type: Reaction
kinetic law: 082985
product: 082973
reactant: 082961
fast: false
reversible: true
name: v180 (ErbB4:ErbB2)#P:GAP:Shc -> (ErbB4:ErbB2)#P:GAP:Shc k6 kd6

082973
type: SpeciesReference
stoichiometry: 1.0
species: 326447

326447
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Shc

082961
type: SpeciesReference
stoichiometry: 1.0
species: 326445

327045
type: Reaction
kinetic law: 077321
product: 077309
reactant: 077297
reactant: 077285
fast: false
reversible: true
name: v50 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4 kd4

077309
type: SpeciesReference
stoichiometry: 1.0
species: 326086

326086
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP

077297
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077285
type: SpeciesReference
stoichiometry: 1.0
species: 326084

W3 CDTF: Mon Jul 26 18:39:07 BST 2010

325920
type: Species
boundary condition: false
notes: ErbB2:ErbB4 , plasma membrane
has only substance units: true
initial concentration: NaN
initial amount: 0.0
has part: P04626
in compartment: 325898
has part: Q15303
name: ErbB2:ErbB4
constant: false

326441
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Shc

327689
type: Reaction
kinetic law: 092491
product: 092479
reactant: 092467
fast: false
reversible: true
name: v381 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23

092479
type: SpeciesReference
stoichiometry: 1.0
species: 326449

326449
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P)

092467
type: SpeciesReference
stoichiometry: 1.0
species: 326441

327979
type: Reaction
kinetic law: 099260
product: 099248
reactant: 099236
fast: false
reversible: true
name: v526 2(EGF:ErbB1)#P:GAP:Grb2 -> R_degraded k60 kd60

099248
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099236
type: SpeciesReference
stoichiometry: 1.0
species: 326419

326419
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2

328499
type: Reaction
kinetic law: 110844
product: 110832
reactant: 110820
reactant: 110808
fast: false
reversible: true
name: v791 + (HRG:ErbB4) -> k120 kd120

110832
type: SpeciesReference
stoichiometry: 1.0
species: 326050

326050
type: Species
notes: ((HRG:ErbB4):ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ((HRG:ErbB4):ErbB2)

110820
type: SpeciesReference
stoichiometry: 1.0
species: 326907

326907
type: Species
notes: (HRG:ErbB4) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB4)

110808
type: SpeciesReference
stoichiometry: 1.0
species: 325950

325950
type: Species
notes: ErbB2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB2

327333
type: Reaction
kinetic law: 083889
product: 083877
reactant: 083865
reactant: 083853
fast: false
reversible: true
name: v202 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8

083877
type: SpeciesReference
stoichiometry: 1.0
species: 326507

326507
type: Species
notes: (ErbB3:ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP

083865
type: SpeciesReference
stoichiometry: 1.0
species: 325918

325918
type: Species
initial amount: 0.0
has only substance units: true
has part: P04626
boundary condition: false
has part: P21860
constant: false
notes: (ErbB3:ErbB2)#P , plasma membrane
has version: C00562
name: (ErbB3:ErbB2)_P
initial concentration: NaN
in compartment: 325898

083853
type: SpeciesReference
stoichiometry: 1.0
species: 326493

329161
type: Parameter
constant: true
value: 5.7E-4
name: k61

328049
type: Reaction
kinetic law: 100521
product: 100509
reactant: 100497
fast: false
reversible: true
name: v564 (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> R_degraded k60b kd60

100509
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100497
type: SpeciesReference
stoichiometry: 1.0
species: 326361

329017
type: Parameter
constant: true
value: 0.0
name: kd15

325976
type: Species
notes: ErbB3:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3:Inh

327733
type: Reaction
kinetic law: 093392
product: 093380
reactant: 093368
reactant: 093356
fast: false
reversible: true
name: v403 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093380
type: SpeciesReference
stoichiometry: 1.0
species: 326217

326217
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos

093368
type: SpeciesReference
stoichiometry: 1.0
species: 326213

093356
type: SpeciesReference
stoichiometry: 1.0
species: 326539

325972
type: Species
notes: ErbB4:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4:Inh

328253
type: Reaction
kinetic law: 104929
product: 104917
reactant: 104905
reactant: 104893
fast: false
reversible: true
name: v668 ErbB3 + Inh -> ErbB3:Inh k100 kd100

104917
type: SpeciesReference
stoichiometry: 1.0
species: 325976

104905
type: SpeciesReference
stoichiometry: 1.0
species: 326775

104893
type: SpeciesReference
stoichiometry: 1.0
species: 325942

327321
type: Reaction
kinetic law: 083600
product: 083588
reactant: 083576
reactant: 083564
fast: false
reversible: true
name: v196 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b

083588
type: SpeciesReference
stoichiometry: 1.0
species: 326499

326499
type: Species
notes: (ErbB1:ErbB4)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP

083576
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083564
type: SpeciesReference
stoichiometry: 1.0
species: 326471

326471
type: Species
notes: (ErbB1:ErbB4)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P

328543
type: Reaction
kinetic law: 111888
product: 111876
reactant: 111864
reactant: 111852
fast: false
reversible: true
name: v814 2(ErbB2)#P + ATP -> ErbB2:ErbB2#P:ATP k123 kd123

111876
type: SpeciesReference
stoichiometry: 1.0
species: 326000

111864
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111852
type: SpeciesReference
stoichiometry: 1.0
species: 326473

329115
type: Parameter
constant: true
value: 0.8
name: kd47

328037
type: Reaction
kinetic law: 100304
product: 100292
reactant: 100280
fast: false
reversible: true
name: v556 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

100292
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100280
type: SpeciesReference
stoichiometry: 1.0
species: 326373

329361
type: Parameter
constant: true
value: 0.0
name: k118

327227
type: Reaction
kinetic law: 081708
product: 081696
reactant: 081684
reactant: 081672
fast: false
reversible: true
name: v148 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b

081696
type: SpeciesReference
stoichiometry: 1.0
species: 326110

326110
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:cPP

081684
type: SpeciesReference
stoichiometry: 1.0
species: 326395

326395
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos

081672
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326024
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:ATP

327393
type: Reaction
kinetic law: 085326
product: 085314
reactant: 085302
reactant: 085290
fast: false
reversible: true
name: v233 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

085314
type: SpeciesReference
stoichiometry: 1.0
species: 326245

085302
type: SpeciesReference
stoichiometry: 1.0
species: 326449

085290
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328407
type: Reaction
kinetic law: 108640
product: 108628
reactant: 108616
reactant: 108604
fast: false
reversible: true
name: v745 ERK#P#P + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111

108628
type: SpeciesReference
stoichiometry: 1.0
species: 326825

326825
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP

108616
type: SpeciesReference
stoichiometry: 1.0
species: 326857

326857
type: Species
notes: ErbB1:ErbB:Gab1#P## , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ErbB1:ErbB:Gab1_P#

108604
type: SpeciesReference
stoichiometry: 1.0
species: 326627

326219
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP

327767
type: Reaction
kinetic law: 094213
product: 094201
reactant: 094189
reactant: 094177
fast: false
reversible: true
name: v420 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094201
type: SpeciesReference
stoichiometry: 1.0
species: 326395

094189
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094177
type: SpeciesReference
stoichiometry: 1.0
species: 326499

327505
type: Reaction
kinetic law: 088022
product: 088010
reactant: 087998
reactant: 087986
fast: false
reversible: true
name: v289 Ras:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088010
type: SpeciesReference
stoichiometry: 1.0
species: 326221

326221
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

087998
type: SpeciesReference
stoichiometry: 1.0
species: 326217

087986
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328343
type: Reaction
kinetic law: 107099
product: 107087
reactant: 107074
reactant: 107062
fast: false
reversible: true
name: v713 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k107 kd107

107087
type: SpeciesReference
stoichiometry: 1.0
species: 326819

326819
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):Shp2

107074
type: SpeciesReference
stoichiometry: 1.0
species: 326679

107062
type: SpeciesReference
stoichiometry: 1.0
species: 326805

327853
type: Reaction
kinetic law: 096270
product: 096258
reactant: 096246
reactant: 096234
fast: false
reversible: true
name: v463 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

096258
type: SpeciesReference
stoichiometry: 1.0
species: 326357

096246
type: SpeciesReference
stoichiometry: 1.0
species: 326525

096234
type: SpeciesReference
stoichiometry: 1.0
species: 326483

328287
type: Reaction
kinetic law: 105750
product: 105738
reactant: 105726
reactant: 105714
fast: false
reversible: true
name: v685 ErbB2 + ErbB4:Inh -> ErbB4:Inh:ErbB2 k103 kd103

105738
type: SpeciesReference
stoichiometry: 1.0
species: 326789

326789
type: Species
notes: ErbB4:Inh:ErbB2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4:Inh:ErbB2

105726
type: SpeciesReference
stoichiometry: 1.0
species: 325972

105714
type: SpeciesReference
stoichiometry: 1.0
species: 325938

327441
type: Reaction
kinetic law: 086484
product: 086472
reactant: 086459
reactant: 086447
fast: false
reversible: true
name: v257 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

086472
type: SpeciesReference
stoichiometry: 1.0
species: 326417

326417
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)

086459
type: SpeciesReference
stoichiometry: 1.0
species: 326421

086447
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328437
type: Reaction
kinetic law: 109363
product: 109351
reactant: 109339
reactant: 109327
fast: false
reversible: true
name: v760 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113

109351
type: SpeciesReference
stoichiometry: 1.0
species: 326867

326867
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP

109339
type: SpeciesReference
stoichiometry: 1.0
species: 326693

326693
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K

109327
type: SpeciesReference
stoichiometry: 1.0
species: 326543

327905
type: Reaction
kinetic law: 097525
product: 097513
reactant: 097501
reactant: 097489
fast: false
reversible: true
name: v489 Raf + Pase1 -> Raf#P:Pase1 k43 kd43

097513
type: SpeciesReference
stoichiometry: 1.0
species: 326583

326583
type: Species
notes: Raf#P:Pase1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Raf_P:Pase1

097501
type: SpeciesReference
stoichiometry: 1.0
species: 326579

326579
type: Species
initial amount: 50000.0
initial concentration: NaN
has only substance units: true
constant: false
name: Pase1
is version of: P28562
notes: Pase1 , cytoplasm
boundary condition: false
in compartment: 325908

097489
type: SpeciesReference
stoichiometry: 1.0
species: 326565

326565
type: Species
is version of: P04049
in compartment: 325908
notes: Raf , cytoplasm
initial concentration: NaN
boundary condition: false
is described by: http://identifiers.org/omim/164760
constant: false
has only substance units: true
initial amount: 71131.2
name: Raf

327811
type: Reaction
kinetic law: 095273
product: 095261
reactant: 095249
reactant: 095237
fast: false
reversible: true
name: v442 Sos + Grb2 -> Grb2:Sos k35 kd35

095261
type: SpeciesReference
stoichiometry: 1.0
species: 326577

095249
type: SpeciesReference
stoichiometry: 1.0
species: 326521

095237
type: SpeciesReference
stoichiometry: 1.0
species: 326539

325910
type: Species
constant: false
is: SBO:0000297
has only substance units: false
substance units: mole
is version of: GO:0005154
boundary condition: true
notes: EGF , medium
name: EGF
initial concentration: 1.0E-11
initial amount: NaN
is version of: P01133
in compartment: 325904

328105
type: Reaction
kinetic law: 101530
product: 101518
reactant: 101506
fast: false
reversible: true
name: v594 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60

101518
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101506
type: SpeciesReference
stoichiometry: 1.0
species: 326333

326333
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

329035
type: Parameter
constant: true
value: 1.1068E-5
name: k20

329175
type: Parameter
notes: %
constant: true
value: 1.5E-5
name: k66

326993
type: Reaction
kinetic law: 076067
product: 076055
reactant: 076043
reactant: 076031
fast: false
reversible: true
name: v24 2(EGF:ErbB1:ATP) + ATP -> 2(EGF:ErbB1):ATP k122 kd122

076055
type: SpeciesReference
stoichiometry: 1.0
species: 325988

325988
type: Species
in compartment: 325908
boundary condition: false
name: 2(EGF:ErbB1):ATP
has part: P00533
initial concentration: NaN
constant: false
initial amount: 0.0
notes: 2(EGF:ErbB1):ATP , cytoplasm
has only substance units: true
has version: P01133

076043
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076031
type: SpeciesReference
stoichiometry: 1.0
species: 325936

325936
type: Species
name: 2(EGF:ErbB1:ATP)
initial amount: 0.0
initial concentration: NaN
has part: CHEBI:15422
boundary condition: false
has version: P01133
has only substance units: true
has part: P00533
in compartment: 325906
notes: 2(EGF:ErbB1:ATP) , endosomal membrane
constant: false

327085
type: Reaction
kinetic law: 078286
product: 078274
reactant: 078262
reactant: 078250
fast: false
reversible: true
name: v71 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4

078274
type: SpeciesReference
stoichiometry: 1.0
species: 326195

326195
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP):cPP

078262
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078250
type: SpeciesReference
stoichiometry: 1.0
species: 326193

326193
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)

328997
type: Parameter
constant: true
value: 0.02
name: kd8b

327245
type: Reaction
kinetic law: 082141
product: 082129
reactant: 082117
reactant: 082105
fast: false
reversible: true
name: v158 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k5 kd5

082129
type: SpeciesReference
stoichiometry: 1.0
species: 326074

326074
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:cPP

082117
type: SpeciesReference
stoichiometry: 1.0
species: 326413

082105
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329401
type: Parameter
constant: true
value: 1.0
name: KD

327001
type: Reaction
kinetic law: 076259
product: 076247
reactant: 076235
reactant: 076223
fast: false
reversible: true
name: v28 EGF:ErbB1:ErbB4 + ATP -> EGF:ErbB1:ErbB4:ATP k122 kd122

076247
type: SpeciesReference
stoichiometry: 1.0
species: 325996

325996
type: Species
initial amount: 0.0
has version: P01133
notes: EGF:ErbB1:ErbB4:ATP , cytoplasm
name: EGF:ErbB1:ErbB4:ATP
has part: P00533
initial concentration: NaN
in compartment: 325908
has only substance units: true
constant: false
boundary condition: false

076235
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076223
type: SpeciesReference
stoichiometry: 1.0
species: 325948

325948
type: Species
has part: P00533
initial amount: 0.0
initial concentration: NaN
constant: false
notes: EGF:ErbB1:ErbB4 , plasma membrane
name: EGF:ErbB1:ErbB4
has only substance units: true
has version: P01133
boundary condition: false
in compartment: 325898

329069
type: Parameter
constant: true
value: 0.1
name: kd32

327871
type: Reaction
kinetic law: 096704
product: 096692
reactant: 096680
reactant: 096668
fast: false
reversible: true
name: v472 Sos + (Shc#P):Grb2 -> (Shc#P):Grb2:Sos k40 kd40

096692
type: SpeciesReference
stoichiometry: 1.0
species: 326575

096680
type: SpeciesReference
stoichiometry: 1.0
species: 326525

096668
type: SpeciesReference
stoichiometry: 1.0
species: 326539

329371
type: Parameter
constant: false
value: 0.1
name: kd120

328455
type: Reaction
kinetic law: 109783
product: 109771
reactant: 109759
fast: false
reversible: true
name: v769 Pase3 + -> MKP_deg k116 kd116

109771
type: SpeciesReference
stoichiometry: 1.0
species: 326883

326883
type: Species
notes: MKP_deg , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MKP_deg

109759
type: SpeciesReference
stoichiometry: 1.0
species: 326631

329265
type: Parameter
notes: % high affnity Iressa
constant: true
value: 3.0E-9
name: KD_iressa_mt

326014
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1

327553
type: Reaction
kinetic law: 089180
product: 089168
reactant: 089156
reactant: 089144
fast: false
reversible: true
name: v313 Ras_activated:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089168
type: SpeciesReference
stoichiometry: 1.0
species: 326265

089156
type: SpeciesReference
stoichiometry: 1.0
species: 326277

089144
type: SpeciesReference
stoichiometry: 1.0
species: 326547

329337
type: Parameter
notes: %AKT aktiviert Ras
constant: true
value: 0.0047067
name: k112

327923
type: Reaction
kinetic law: 097959
product: 097946
reactant: 097934
reactant: 097922
fast: false
reversible: true
name: v498 (Raf#P)_i + (MEK#P#P)_i -> (MEK#P:Raf#P)_i k47 kd47

097946
type: SpeciesReference
stoichiometry: 1.0
species: 326587

326587
type: Species
notes: (MEK#P:Raf#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_P:Raf_P)_i

097934
type: SpeciesReference
stoichiometry: 1.0
species: 326601

097922
type: SpeciesReference
stoichiometry: 1.0
species: 326571

326455
type: Species
notes: ErbB4:Inh , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB4:Inh

328507
type: Reaction
kinetic law: 111036
product: 111024
reactant: 111012
reactant: 111000
fast: false
reversible: true
name: v795 EGF + ErbB1_h:Inh -> EGF:ErbB1_h:Inh k1 kd1

111024
type: SpeciesReference
stoichiometry: 1.0
species: 326913

326913
type: Species
notes: EGF:ErbB1_h:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: EGF:ErbB1_h:Inh

111012
type: SpeciesReference
stoichiometry: 1.0
species: 326911

111000
type: SpeciesReference
stoichiometry: 1.0
species: 325910

328123
type: Reaction
kinetic law: 101857
product: 101845
reactant: 101833
fast: false
reversible: true
name: v603 (HRG:ErbB3:ErbB1) -> R_degraded k62b kd60b

101845
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101833
type: SpeciesReference
stoichiometry: 1.0
species: 326647

326943
type: Species
notes: 2(EGF:ErbB1_h:ATP)-FullActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1_h:ATP)-FullActive

327633
type: Reaction
kinetic law: 091156
product: 091144
reactant: 091132
reactant: 091120
fast: false
reversible: true
name: v353 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091144
type: SpeciesReference
stoichiometry: 1.0
species: 326189

326189
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

091132
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091120
type: SpeciesReference
stoichiometry: 1.0
species: 326201

326136
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2

328319
type: Reaction
kinetic law: 106522
product: 106510
reactant: 106498
reactant: 106486
fast: false
reversible: true
name: v701 PIP2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> PI3K k106 kd106

106510
type: SpeciesReference
stoichiometry: 1.0
species: 326803

326803
type: Species
has part: P27986
initial concentration: NaN
notes: PI3K , cytoplasm
has part: P42338
in compartment: 325908
boundary condition: false
has part: O00459
initial amount: 0.0
name: PI3K
constant: false
has part: P42336
has only substance units: true
is version of: REACT 4240.1

106498
type: SpeciesReference
stoichiometry: 1.0
species: 326705

106486
type: SpeciesReference
stoichiometry: 1.0
species: 326793

326261
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

328153
type: Reaction
kinetic law: 102518
product: 102506
reactant: 102494
reactant: 102482
fast: false
reversible: true
name: v618 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65

102506
type: SpeciesReference
stoichiometry: 1.0
species: 326657

102494
type: SpeciesReference
stoichiometry: 1.0
species: 326673

326673
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Sos_P)

102482
type: SpeciesReference
stoichiometry: 1.0
species: 326629

327679
type: Reaction
kinetic law: 092262
product: 092250
reactant: 092238
reactant: 092226
fast: false
reversible: true
name: v376 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b

092250
type: SpeciesReference
stoichiometry: 1.0
species: 326487

326487
type: Species
notes: 2(ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Shc

092238
type: SpeciesReference
stoichiometry: 1.0
species: 326483

092226
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327069
type: Reaction
kinetic law: 077901
product: 077889
reactant: 077877
reactant: 077865
fast: false
reversible: true
name: v63 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4

077889
type: SpeciesReference
stoichiometry: 1.0
species: 326134

326134
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP

077877
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077865
type: SpeciesReference
stoichiometry: 1.0
species: 326132

326132
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

327829
type: Reaction
kinetic law: 095693
product: 095681
reactant: 095669
reactant: 095657
fast: false
reversible: true
name: v451 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37

095681
type: SpeciesReference
stoichiometry: 1.0
species: 326533

326533
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P)

095669
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095657
type: SpeciesReference
stoichiometry: 1.0
species: 326495

326495
type: Species
notes: (ErbB1:ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP

328939
type: Parameter
constant: true
units: item
value: 695000.0
name: total ERK

327417
type: Reaction
kinetic law: 085905
product: 085893
reactant: 085881
reactant: 085869
fast: false
reversible: true
name: v245 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17

085893
type: SpeciesReference
stoichiometry: 1.0
species: 326233

085881
type: SpeciesReference
stoichiometry: 1.0
species: 326229

085869
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326040
type: Species
notes: (HRG:ErbB4):ErbB2:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (HRG:ErbB4):ErbB2:ATP

326465
type: Species
notes: (ErbB1:ErbB3)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P

326871
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP

327357
type: Reaction
kinetic law: 084457
product: 084445
reactant: 084433
reactant: 084421
fast: false
reversible: true
name: v215 2(EGF:ErbB1)#P:GAP + Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63

084445
type: SpeciesReference
stoichiometry: 1.0
species: 326419

084433
type: SpeciesReference
stoichiometry: 1.0
species: 326521

084421
type: SpeciesReference
stoichiometry: 1.0
species: 326431

329185
type: Parameter
constant: true
value: 0.0
name: k68

326809
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:Shp2

327723
type: Reaction
kinetic law: 093152
product: 093140
reactant: 093128
reactant: 093116
fast: false
reversible: true
name: v398 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093140
type: SpeciesReference
stoichiometry: 1.0
species: 326104

326104
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos

093128
type: SpeciesReference
stoichiometry: 1.0
species: 326092

326092
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2

093116
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328243
type: Reaction
kinetic law: 104688
product: 104676
reactant: 104664
reactant: 104652
fast: false
reversible: true
name: v663 RTK_Pase + (ErbB4:ErbB2) -> (ErbB2:ErbB4)#P:RTK_Pase k95 kd95

104676
type: SpeciesReference
stoichiometry: 1.0
species: 326767

326767
type: Species
notes: (ErbB2:ErbB4)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB2:ErbB4)_P:RTK_Pase

104664
type: SpeciesReference
stoichiometry: 1.0
species: 326653

104652
type: SpeciesReference
stoichiometry: 1.0
species: 326755

327113
type: Reaction
kinetic law: 078959
product: 078947
reactant: 078935
reactant: 078923
fast: false
reversible: true
name: v88 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4

078947
type: SpeciesReference
stoichiometry: 1.0
species: 326251

326251
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:cPP

078935
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078923
type: SpeciesReference
stoichiometry: 1.0
species: 326249

326969
type: Reaction
kinetic law: 075458
product: 075446
reactant: 075435
reactant: 075423
fast: false
reversible: true
name: v12 EGF:ErbB1:ATP + ErbB2 -> (EGF:ErbB1:ErbB2) k2b kd2b

075446
type: SpeciesReference
stoichiometry: 1.0
species: 325952

075435
type: SpeciesReference
stoichiometry: 1.0
species: 325950

075423
type: SpeciesReference
stoichiometry: 1.0
species: 325934

325934
type: Species
has version: P01133
has part: CHEBI:15422
has part: P00533
boundary condition: false
in compartment: 325906
has only substance units: true
name: EGF:ErbB1:ATP
constant: false
notes: EGF:ErbB1:ATP , endosomal membrane
initial amount: 0.0
initial concentration: NaN

326743
type: Species
notes: PIP3:AKT:PDK1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT:PDK1

327983
type: Reaction
kinetic law: 099332
product: 099320
reactant: 099308
fast: false
reversible: true
name: v528 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60

099320
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099308
type: SpeciesReference
stoichiometry: 1.0
species: 326417

328567
type: Reaction
kinetic law: 112504
product: 112492
reactant: 112479
reactant: 112466
fast: false
reversible: true
name: v826 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2):ATP k123 kd123

112492
type: SpeciesReference
stoichiometry: 1.0
species: 326048

112479
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112466
type: SpeciesReference
stoichiometry: 1.0
species: 326477

328183
type: Reaction
kinetic law: 103242
product: 103230
reactant: 103218
reactant: 103206
fast: false
reversible: true
name: v633 PIP3 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68

103230
type: SpeciesReference
stoichiometry: 1.0
species: 326719

326719
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K:PIP2

103218
type: SpeciesReference
stoichiometry: 1.0
species: 326685

103206
type: SpeciesReference
stoichiometry: 1.0
species: 326707

329245
type: Parameter
constant: true
value: 0.0
name: kd6b

327281
type: Reaction
kinetic law: 082840
product: 082828
reactant: 082816
fast: false
reversible: true
name: v176 ErbB3 -> ErbB3 k6b kd6b

082828
type: SpeciesReference
stoichiometry: 1.0
species: 325954

082816
type: SpeciesReference
stoichiometry: 1.0
species: 325942

326269
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

327041
type: Reaction
kinetic law: 077225
product: 077213
reactant: 077201
reactant: 077189
fast: false
reversible: true
name: v48 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k4 kd4

077213
type: SpeciesReference
stoichiometry: 1.0
species: 326078

077201
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077189
type: SpeciesReference
stoichiometry: 1.0
species: 326076

329139
type: Parameter
constant: true
value: 0.0
name: k55

326609
type: Species
notes: MEK#P:Pase2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_P:Pase2

327477
type: Reaction
kinetic law: 087349
product: 087337
reactant: 087325
reactant: 087313
fast: false
reversible: true
name: v275 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

087337
type: SpeciesReference
stoichiometry: 1.0
species: 326261

087325
type: SpeciesReference
stoichiometry: 1.0
species: 326253

087313
type: SpeciesReference
stoichiometry: 1.0
species: 326541

326851
type: Species
notes: 2(ErbB2)2:Gab1#P## , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)2:Gab1_P#

327681
type: Reaction
kinetic law: 092310
product: 092298
reactant: 092286
reactant: 092274
fast: false
reversible: true
name: v377 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b

092298
type: SpeciesReference
stoichiometry: 1.0
species: 326441

092286
type: SpeciesReference
stoichiometry: 1.0
species: 326507

092274
type: SpeciesReference
stoichiometry: 1.0
species: 326551

329347
type: Parameter
constant: true
value: 0.1
name: kd114

328491
type: Reaction
kinetic law: 110652
product: 110640
reactant: 110628
reactant: 110616
fast: false
reversible: true
name: v787 (HRG:ErbB3) + ErbB2 -> (HRG:ErbB3):ErbB2) k120 kd120

110640
type: SpeciesReference
stoichiometry: 1.0
species: 326046

110628
type: SpeciesReference
stoichiometry: 1.0
species: 325950

110616
type: SpeciesReference
stoichiometry: 1.0
species: 326519

327529
type: Reaction
kinetic law: 088602
product: 088590
reactant: 088578
reactant: 088566
fast: false
reversible: true
name: v301 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088590
type: SpeciesReference
stoichiometry: 1.0
species: 326148

326148
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

088578
type: SpeciesReference
stoichiometry: 1.0
species: 326201

088566
type: SpeciesReference
stoichiometry: 1.0
species: 326543

326933
type: Species
notes: 2(EGF:ErbB1_h:ATP)-FullActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1_h:ATP)-FullActive

326567
type: Species
notes: Raf:Ras:GTP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Raf:Ras:GTP

326317
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

328949
type: Parameter
constant: false
value: 0.033
name: kd1

328355
type: Reaction
kinetic law: 107387
product: 107375
reactant: 107363
reactant: 107351
fast: false
reversible: true
name: v719 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108

107375
type: SpeciesReference
stoichiometry: 1.0
species: 326817

107363
type: SpeciesReference
stoichiometry: 1.0
species: 326022

107351
type: SpeciesReference
stoichiometry: 1.0
species: 326805

327835
type: Reaction
kinetic law: 095838
product: 095826
reactant: 095814
reactant: 095802
fast: false
reversible: true
name: v454 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

095826
type: SpeciesReference
stoichiometry: 1.0
species: 326088

326088
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2

095814
type: SpeciesReference
stoichiometry: 1.0
species: 326525

095802
type: SpeciesReference
stoichiometry: 1.0
species: 326501

328129
type: Reaction
kinetic law: 101965
product: 101953
reactant: 101941
fast: false
reversible: true
name: v606 (HRG:ErbB4):ErbB2) -> R_degraded k62b kd60b

101953
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101941
type: SpeciesReference
stoichiometry: 1.0
species: 326050

326030
type: Species
notes: (HRG:ErbB3:ErbB1) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB3:ErbB1)

329221
type: Parameter
constant: true
value: 0.0
name: kd60d

329059
type: Parameter
constant: true
value: 0.0053
name: kd28

328033
type: Reaction
kinetic law: 100232
product: 100220
reactant: 100208
fast: false
reversible: true
name: v554 (ErbB1:ErbB4)#P:GAP:Grb2 -> R_degraded k60b kd60

100220
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100208
type: SpeciesReference
stoichiometry: 1.0
species: 326377

329191
type: Parameter
constant: true
value: 0.1
name: kd69

326152
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)

326975
type: Reaction
kinetic law: 075610
product: 075597
reactant: 075584
reactant: 075571
fast: false
reversible: true
name: v15 EGF:ErbB1:Inh + ErbB2 -> EGF:ErbB1:Inh:ErB2 k2b kd2b

075597
type: SpeciesReference
stoichiometry: 1.0
species: 325962

325962
type: Species
boundary condition: false
initial concentration: NaN
in compartment: 325898
has version: P01133
has only substance units: true
constant: false
notes: EGF:ErbB1:Inh:ErB2 , plasma membrane
name: EGF:ErbB1:Inh:ErB2
initial amount: 0.0
has part: P00533

075584
type: SpeciesReference
stoichiometry: 1.0
species: 325938

075571
type: SpeciesReference
stoichiometry: 1.0
species: 325926

327495
type: Reaction
kinetic law: 087782
product: 087770
reactant: 087758
reactant: 087746
fast: false
reversible: true
name: v284 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

087770
type: SpeciesReference
stoichiometry: 1.0
species: 326317

087758
type: SpeciesReference
stoichiometry: 1.0
species: 326321

326321
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos

087746
type: SpeciesReference
stoichiometry: 1.0
species: 326545

327269
type: Reaction
kinetic law: 082623
product: 082611
reactant: 082599
fast: false
reversible: true
name: v170 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k6 kd6

082611
type: SpeciesReference
stoichiometry: 1.0
species: 326415

326415
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)

082599
type: SpeciesReference
stoichiometry: 1.0
species: 326068

328079
type: Reaction
kinetic law: 101061
product: 101049
reactant: 101037
fast: false
reversible: true
name: v581 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60

101049
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101037
type: SpeciesReference
stoichiometry: 1.0
species: 326451

326451
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P)

329365
type: Parameter
constant: true
value: 0.0103115
name: kd119

328283
type: Reaction
kinetic law: 105653
product: 105641
reactant: 105629
reactant: 105617
fast: false
reversible: true
name: v683 ErbB2:Inh + ErbB3 -> ErbB3:ErbB2:Inh k103 kd103

105641
type: SpeciesReference
stoichiometry: 1.0
species: 326785

326785
type: Species
notes: ErbB3:ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3:ErbB2:Inh

105629
type: SpeciesReference
stoichiometry: 1.0
species: 325942

105617
type: SpeciesReference
stoichiometry: 1.0
species: 325968

327959
type: Reaction
kinetic law: 098825
product: 098813
reactant: 098801
reactant: 098789
fast: false
reversible: true
name: v516 (ERK#P#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k56 kd56

098813
type: SpeciesReference
stoichiometry: 1.0
species: 326635

326635
type: Species
notes: (ERK#P#P:Pase3)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_PP:Pase3)_i

098801
type: SpeciesReference
stoichiometry: 1.0
species: 326631

098789
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328219
type: Reaction
kinetic law: 104108
product: 104096
reactant: 104084
reactant: 104072
fast: false
reversible: true
name: v651 RTK_Pase + (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P:RTK_Pase k94b kd94

104096
type: SpeciesReference
stoichiometry: 1.0
species: 326759

326759
type: Species
notes: (ErbB1:ErbB4)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:RTK_Pase

104084
type: SpeciesReference
stoichiometry: 1.0
species: 326471

104072
type: SpeciesReference
stoichiometry: 1.0
species: 326755

327547
type: Reaction
kinetic law: 089036
product: 089024
reactant: 089012
reactant: 089000
fast: false
reversible: true
name: v310 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

089024
type: SpeciesReference
stoichiometry: 1.0
species: 326333

089012
type: SpeciesReference
stoichiometry: 1.0
species: 326337

326337
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos

089000
type: SpeciesReference
stoichiometry: 1.0
species: 326545

329255
type: Parameter
constant: true
value: 5.2E-4
name: k60c

329395
type: Parameter
constant: true
value: 1.0E-4
name: KD_ATP

328479
type: Reaction
kinetic law: 110363
product: 110351
reactant: 110339
reactant: 110327
fast: false
reversible: true
name: v781 Pase9t + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k118 kd118

110351
type: SpeciesReference
stoichiometry: 1.0
species: 326895

326895
type: Species
notes: ErbB3/4:ErbB2:Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3/4:ErbB2:Gab1_P#:Pase9t

110339
type: SpeciesReference
stoichiometry: 1.0
species: 326699

110327
type: SpeciesReference
stoichiometry: 1.0
species: 326885

326038
type: Species
notes: (HRG:ErbB4):ErbB2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB4):ErbB2

326841
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP

327577
type: Reaction
kinetic law: 089795
product: 089782
reactant: 089769
reactant: 089756
fast: false
reversible: true
name: v325 Ras_activated:GTP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089782
type: SpeciesReference
stoichiometry: 1.0
species: 326124

089769
type: SpeciesReference
stoichiometry: 1.0
species: 326100

089756
type: SpeciesReference
stoichiometry: 1.0
species: 326547

327193
type: Reaction
kinetic law: 080884
product: 080872
reactant: 080860
reactant: 080848
fast: false
reversible: true
name: v129 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k5 kd5b

080872
type: SpeciesReference
stoichiometry: 1.0
species: 326207

326207
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:cPP

080860
type: SpeciesReference
stoichiometry: 1.0
species: 326361

080848
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326479
type: Species
notes: (ErbB4:ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P

328147
type: Reaction
kinetic law: 102374
product: 102362
reactant: 102350
reactant: 102338
fast: false
reversible: true
name: v615 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65

102362
type: SpeciesReference
stoichiometry: 1.0
species: 326655

326655
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(ERK_PP)

102350
type: SpeciesReference
stoichiometry: 1.0
species: 326667

102338
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327301
type: Reaction
kinetic law: 083203
product: 083191
reactant: 083179
fast: false
reversible: true
name: v186 (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P k7 kd7

083191
type: SpeciesReference
stoichiometry: 1.0
species: 326467

083179
type: SpeciesReference
stoichiometry: 1.0
species: 326465

328523
type: Reaction
kinetic law: 111408
product: 111396
reactant: 111384
reactant: 111372
fast: false
reversible: true
name: v804 2(EGF:ErbB1)#P + ATP -> k123 kd123

111396
type: SpeciesReference
stoichiometry: 1.0
species: 325990

325990
type: Species
has part: P00533
initial concentration: NaN
has version: P01133
initial amount: 0.0
has only substance units: true
in compartment: 325908
boundary condition: false
notes: 2(EGF:ErbB1:ATP)-FullActive , cytoplasm
name: 2(EGF:ErbB1:ATP)-FullActive
constant: false

111384
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111372
type: SpeciesReference
stoichiometry: 1.0
species: 326425

328511
type: Reaction
kinetic law: 111132
product: 111120
reactant: 111108
reactant: 111096
fast: false
reversible: true
name: v797 EGF:ErbB1_h:Inh + EGF:ErbB1_h:Inh -> 2(EGF:ErbB1_h:Inh) k2 kd2

111120
type: SpeciesReference
stoichiometry: 1.0
species: 326917

111108
type: SpeciesReference
stoichiometry: 1.0
species: 326913

111096
type: SpeciesReference
stoichiometry: 1.0
species: 326913

326064
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)

326090
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:cPP

327107
type: Reaction
kinetic law: 078815
product: 078803
reactant: 078791
reactant: 078779
fast: false
reversible: true
name: v84 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4

078803
type: SpeciesReference
stoichiometry: 1.0
species: 326239

078791
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078779
type: SpeciesReference
stoichiometry: 1.0
species: 326237

325994
type: Species
boundary condition: false
name: EGF:ErbB1:ErbB3:ATP
initial amount: 0.0
constant: false
initial concentration: NaN
in compartment: 325908
has version: P01133
notes: EGF:ErbB1:ErbB3:ATP , cytoplasm
has part: P00533
has only substance units: true

326645
type: Species
notes: EGF_degraded , lysosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325902
name: EGF_degraded

329065
type: Parameter
constant: true
value: 1.17E-6
name: k29

327747
type: Reaction
kinetic law: 093729
product: 093717
reactant: 093705
reactant: 093693
fast: false
reversible: true
name: v410 (Ras:GTP)_i + Raf -> (Raf:Ras:GTP)_i k28 kd28

093717
type: SpeciesReference
stoichiometry: 1.0
species: 326569

326569
type: Species
notes: (Raf:Ras:GTP)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Raf:Ras:GTP)_i

093705
type: SpeciesReference
stoichiometry: 1.0
species: 326565

093693
type: SpeciesReference
stoichiometry: 1.0
species: 326545

327137
type: Reaction
kinetic law: 079540
product: 079528
reactant: 079516
reactant: 079503
fast: false
reversible: true
name: v100 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4

079528
type: SpeciesReference
stoichiometry: 1.0
species: 326299

326299
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP

079516
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079503
type: SpeciesReference
stoichiometry: 1.0
species: 326297

328267
type: Reaction
kinetic law: 105267
product: 105255
reactant: 105243
reactant: 105231
fast: false
reversible: true
name: v675 EGF:ErbB1#P + ErbB3#P -> (ErbB1:ErbB3)#P k102 kd102

105255
type: SpeciesReference
stoichiometry: 1.0
species: 326465

105243
type: SpeciesReference
stoichiometry: 1.0
species: 326779

326779
type: Species
notes: ErbB3#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3_P

105231
type: SpeciesReference
stoichiometry: 1.0
species: 326777

326777
type: Species
notes: EGF:ErbB1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: EGF:ErbB1_P

328005
type: Reaction
kinetic law: 099728
product: 099716
reactant: 099704
fast: false
reversible: true
name: v540 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60

099716
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099704
type: SpeciesReference
stoichiometry: 1.0
species: 326405

326405
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2

327361
type: Reaction
kinetic law: 084553
product: 084541
reactant: 084529
reactant: 084517
fast: false
reversible: true
name: v217 Grb2 + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24

084541
type: SpeciesReference
stoichiometry: 1.0
species: 326136

084529
type: SpeciesReference
stoichiometry: 1.0
species: 326501

084517
type: SpeciesReference
stoichiometry: 1.0
species: 326521

329269
type: Parameter
constant: false
value: 0.001
name: kd97c

328311
type: Reaction
kinetic law: 106328
product: 106316
reactant: 106304
reactant: 106292
fast: false
reversible: true
name: v697 PIP2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b

106316
type: SpeciesReference
stoichiometry: 1.0
species: 326717

326717
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K:PIP2

106304
type: SpeciesReference
stoichiometry: 1.0
species: 326693

106292
type: SpeciesReference
stoichiometry: 1.0
species: 326793

327065
type: Reaction
kinetic law: 077804
product: 077792
reactant: 077780
reactant: 077768
fast: false
reversible: true
name: v61 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4

077792
type: SpeciesReference
stoichiometry: 1.0
species: 326126

326126
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP

077780
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077768
type: SpeciesReference
stoichiometry: 1.0
species: 326124

327671
type: Reaction
kinetic law: 092070
product: 092058
reactant: 092046
reactant: 092034
fast: false
reversible: true
name: v372 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b

092058
type: SpeciesReference
stoichiometry: 1.0
species: 326559

326559
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Shc

092046
type: SpeciesReference
stoichiometry: 1.0
species: 326495

092034
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327821
type: Reaction
kinetic law: 095501
product: 095489
reactant: 095477
reactant: 095465
fast: false
reversible: true
name: v447 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37

095489
type: SpeciesReference
stoichiometry: 1.0
species: 326413

095477
type: SpeciesReference
stoichiometry: 1.0
species: 326525

095465
type: SpeciesReference
stoichiometry: 1.0
species: 326431

328571
type: Reaction
kinetic law: 112601
product: 112589
reactant: 112576
reactant: 112564
fast: false
reversible: true
name: v828 ErbB1 + ATP -> ErbB1:ATP k122 kd122

112589
type: SpeciesReference
stoichiometry: 1.0
species: 325912

325912
type: Species
is: SBO:0000297
initial concentration: NaN
has part: CHEBI:15422
notes: ErbB1:ATP , plasma membrane
initial amount: 0.0
has only substance units: true
in compartment: 325898
has part: P00533
constant: false
boundary condition: false
name: ErbB1:ATP

112576
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112564
type: SpeciesReference
stoichiometry: 1.0
species: 326773

329003
type: Parameter
constant: true
value: 0.05426
name: k10b

327169
type: Reaction
kinetic law: 080308
product: 080296
reactant: 080284
reactant: 080272
fast: false
reversible: true
name: v116 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b

080296
type: SpeciesReference
stoichiometry: 1.0
species: 326255

326255
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP

080284
type: SpeciesReference
stoichiometry: 1.0
species: 326337

080272
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329329
type: Parameter
notes: %ERK inhibiert AKT
constant: true
value: 3.33E-4
name: k110

326961
type: Reaction
kinetic law: 075265
product: 075253
reactant: 075241
reactant: 075229
fast: false
reversible: true
name: v8 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP) k2 kd2

075253
type: SpeciesReference
stoichiometry: 1.0
species: 325936

075241
type: SpeciesReference
stoichiometry: 1.0
species: 325934

075229
type: SpeciesReference
stoichiometry: 1.0
species: 325934

329211
type: Parameter
constant: false
value: 0.355656
name: kd74

328023
type: Reaction
kinetic law: 100052
product: 100040
reactant: 100028
fast: false
reversible: true
name: v549 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100040
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100028
type: SpeciesReference
stoichiometry: 1.0
species: 326387

329189
type: Parameter
constant: true
value: 3.33E-5
name: k69

329105
type: Parameter
constant: true
value: 31.6228
name: kd43

327859
type: Reaction
kinetic law: 096416
product: 096404
reactant: 096392
reactant: 096380
fast: false
reversible: true
name: v466 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37

096404
type: SpeciesReference
stoichiometry: 1.0
species: 326457

096392
type: SpeciesReference
stoichiometry: 1.0
species: 326523

096380
type: SpeciesReference
stoichiometry: 1.0
species: 326509

327099
type: Reaction
kinetic law: 078622
product: 078610
reactant: 078598
reactant: 078586
fast: false
reversible: true
name: v80 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4

078610
type: SpeciesReference
stoichiometry: 1.0
species: 326223

078598
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078586
type: SpeciesReference
stoichiometry: 1.0
species: 326221

328379
type: Reaction
kinetic law: 107966
product: 107954
reactant: 107942
reactant: 107930
fast: false
reversible: true
name: v731 ERK#P#P + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110

107954
type: SpeciesReference
stoichiometry: 1.0
species: 326837

326837
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP

107942
type: SpeciesReference
stoichiometry: 1.0
species: 326695

107930
type: SpeciesReference
stoichiometry: 1.0
species: 326627

325958
type: Species
notes: ErbB4 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB4

327533
type: Reaction
kinetic law: 088698
product: 088686
reactant: 088674
reactant: 088662
fast: false
reversible: true
name: v303 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088686
type: SpeciesReference
stoichiometry: 1.0
species: 326156

326156
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)

088674
type: SpeciesReference
stoichiometry: 1.0
species: 326209

088662
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328965
type: Parameter
constant: true
value: 0.016
name: kd2b

327213
type: Reaction
kinetic law: 081366
product: 081354
reactant: 081342
reactant: 081330
fast: false
reversible: true
name: v141 cPP + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k5 kd5b

081354
type: SpeciesReference
stoichiometry: 1.0
species: 326138

326138
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:cPP

081342
type: SpeciesReference
stoichiometry: 1.0
species: 326381

326381
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2

081330
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329075
type: Parameter
constant: true
value: 3.5E-5
name: k33

329207
type: Parameter
constant: false
value: 0.5
name: kd73

326813
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:Shp2

326999
type: Reaction
kinetic law: 076211
product: 076199
reactant: 076187
reactant: 076175
fast: false
reversible: true
name: v27 EGF:ErbB1:ErbB3 + ATP -> EGF:ErbB1:ErbB3:ATP k122 kd122

076199
type: SpeciesReference
stoichiometry: 1.0
species: 325994

076187
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076175
type: SpeciesReference
stoichiometry: 1.0
species: 325944

326757
type: Species
notes: (ErbB1:ErbB3)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:RTK_Pase

328423
type: Reaction
kinetic law: 109026
product: 109014
reactant: 109002
reactant: 108990
fast: false
reversible: true
name: v753 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112

109014
type: SpeciesReference
stoichiometry: 1.0
species: 326867

109002
type: SpeciesReference
stoichiometry: 1.0
species: 326693

108990
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327783
type: Reaction
kinetic law: 094598
product: 094585
reactant: 094573
reactant: 094561
fast: false
reversible: true
name: v428 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34

094585
type: SpeciesReference
stoichiometry: 1.0
species: 326060

094573
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094561
type: SpeciesReference
stoichiometry: 1.0
species: 326429

327187
type: Reaction
kinetic law: 080740
product: 080728
reactant: 080716
reactant: 080704
fast: false
reversible: true
name: v126 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b

080728
type: SpeciesReference
stoichiometry: 1.0
species: 326219

080716
type: SpeciesReference
stoichiometry: 1.0
species: 326355

080704
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329279
type: Parameter
constant: true
value: 0.5
name: kd99

327337
type: Reaction
kinetic law: 083986
product: 083974
reactant: 083961
reactant: 083949
fast: false
reversible: true
name: v204 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8

083974
type: SpeciesReference
stoichiometry: 1.0
species: 326511

083961
type: SpeciesReference
stoichiometry: 1.0
species: 326477

083949
type: SpeciesReference
stoichiometry: 1.0
species: 326493

327273
type: Reaction
kinetic law: 082695
product: 082683
reactant: 082671
fast: false
reversible: true
name: v172 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k6 kd6

082683
type: SpeciesReference
stoichiometry: 1.0
species: 326411

326411
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos

082671
type: SpeciesReference
stoichiometry: 1.0
species: 326076

328083
type: Reaction
kinetic law: 101133
product: 101121
reactant: 101109
fast: false
reversible: true
name: v583 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60

101121
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101109
type: SpeciesReference
stoichiometry: 1.0
species: 326341

326341
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2

327647
type: Reaction
kinetic law: 091492
product: 091480
reactant: 091468
reactant: 091456
fast: false
reversible: true
name: v360 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

091480
type: SpeciesReference
stoichiometry: 1.0
species: 326331

091468
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091456
type: SpeciesReference
stoichiometry: 1.0
species: 326325

327037
type: Reaction
kinetic law: 077127
product: 077115
reactant: 077103
reactant: 077091
fast: false
reversible: true
name: v46 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4

077115
type: SpeciesReference
stoichiometry: 1.0
species: 326070

326070
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP):cPP

077103
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077091
type: SpeciesReference
stoichiometry: 1.0
species: 326068

327593
type: Reaction
kinetic law: 090192
product: 090180
reactant: 090167
reactant: 090155
fast: false
reversible: true
name: v333 2(ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

090180
type: SpeciesReference
stoichiometry: 1.0
species: 326241

326241
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)

090167
type: SpeciesReference
stoichiometry: 1.0
species: 326547

090155
type: SpeciesReference
stoichiometry: 1.0
species: 326233

328547
type: Reaction
kinetic law: 111988
product: 111975
reactant: 111961
reactant: 111948
fast: false
reversible: true
name: v816 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k123 kd123

111975
type: SpeciesReference
stoichiometry: 1.0
species: 326008

111961
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111948
type: SpeciesReference
stoichiometry: 1.0
species: 326691

328397
type: Reaction
kinetic law: 108400
product: 108388
reactant: 108376
reactant: 108364
fast: false
reversible: true
name: v740 (ERK#P#P)_i + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111

108388
type: SpeciesReference
stoichiometry: 1.0
species: 326839

326839
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i

108376
type: SpeciesReference
stoichiometry: 1.0
species: 326851

108364
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328983
type: Parameter
constant: true
value: 0.0
name: k5b

329013
type: Parameter
constant: true
value: 0.0
name: kd14

329093
type: Parameter
constant: true
value: 5.0E-5
name: k40

327581
type: Reaction
kinetic law: 089899
product: 089886
reactant: 089873
reactant: 089860
fast: false
reversible: true
name: v327 Ras_activated:GTP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089886
type: SpeciesReference
stoichiometry: 1.0
species: 326132

089873
type: SpeciesReference
stoichiometry: 1.0
species: 326108

089860
type: SpeciesReference
stoichiometry: 1.0
species: 326547

329009
type: Parameter
constant: true
value: 0.0
name: kd13

329251
type: Parameter
constant: true
value: 4.16E-4
name: k62b

327951
type: Reaction
kinetic law: 098633
product: 098621
reactant: 098609
reactant: 098597
fast: false
reversible: true
name: v512 MEK#P#P + ERK#P -> ERK:MEK#P#P k53 kd53

098621
type: SpeciesReference
stoichiometry: 1.0
species: 326615

098609
type: SpeciesReference
stoichiometry: 1.0
species: 326617

098597
type: SpeciesReference
stoichiometry: 1.0
species: 326599

326669
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:(Sos_P)

329089
type: Parameter
constant: true
value: 0.3
name: kd37

326531
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P)

328029
type: Reaction
kinetic law: 100160
product: 100148
reactant: 100136
fast: false
reversible: true
name: v552 (ErbB1:ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60

100148
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100136
type: SpeciesReference
stoichiometry: 1.0
species: 326381

326271
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP

327815
type: Reaction
kinetic law: 095357
product: 095345
reactant: 095333
reactant: 095321
fast: false
reversible: true
name: v444 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37

095345
type: SpeciesReference
stoichiometry: 1.0
species: 326437

326437
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P)

095333
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095321
type: SpeciesReference
stoichiometry: 1.0
species: 326429

327055
type: Reaction
kinetic law: 077562
product: 077550
reactant: 077538
reactant: 077526
fast: false
reversible: true
name: v56 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4

077550
type: SpeciesReference
stoichiometry: 1.0
species: 326106

077538
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077526
type: SpeciesReference
stoichiometry: 1.0
species: 326104

329315
type: Parameter
constant: true
value: 0.1
name: kd106b

327751
type: Reaction
kinetic law: 093827
product: 093815
reactant: 093803
reactant: 093791
fast: false
reversible: true
name: v412 Ras_activated:GTP + Raf#P -> Raf:Ras:GTP k29 kd29

093815
type: SpeciesReference
stoichiometry: 1.0
species: 326567

093803
type: SpeciesReference
stoichiometry: 1.0
species: 326573

093791
type: SpeciesReference
stoichiometry: 1.0
species: 326547

327141
type: Reaction
kinetic law: 079636
product: 079624
reactant: 079612
reactant: 079600
fast: false
reversible: true
name: v102 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4

079624
type: SpeciesReference
stoichiometry: 1.0
species: 326307

326307
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP

079612
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079600
type: SpeciesReference
stoichiometry: 1.0
species: 326305

328335
type: Reaction
kinetic law: 106906
product: 106894
reactant: 106882
reactant: 106870
fast: false
reversible: true
name: v709 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107

106894
type: SpeciesReference
stoichiometry: 1.0
species: 326811

106882
type: SpeciesReference
stoichiometry: 1.0
species: 326683

106870
type: SpeciesReference
stoichiometry: 1.0
species: 326805

327695
type: Reaction
kinetic law: 092601
product: 092589
reactant: 092576
fast: false
reversible: true
name: v384 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23

092589
type: SpeciesReference
stoichiometry: 1.0
species: 326459

092576
type: SpeciesReference
stoichiometry: 1.0
species: 326447

329171
type: Parameter
constant: true
value: 0.2
name: kd65

327433
type: Reaction
kinetic law: 086291
product: 086279
reactant: 086267
reactant: 086255
fast: false
reversible: true
name: v253 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17

086279
type: SpeciesReference
stoichiometry: 1.0
species: 326361

086267
type: SpeciesReference
stoichiometry: 1.0
species: 326379

326379
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2

086255
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326263
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP

327803
type: Reaction
kinetic law: 095081
product: 095069
reactant: 095057
reactant: 095045
fast: false
reversible: true
name: v438 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34

095069
type: SpeciesReference
stoichiometry: 1.0
species: 326285

095057
type: SpeciesReference
stoichiometry: 1.0
species: 326577

095045
type: SpeciesReference
stoichiometry: 1.0
species: 326507

326955
type: Reaction
kinetic law: 075121
product: 075109
reactant: 075097
reactant: 075085
fast: false
reversible: true
name: v5 EGF:ErbB1:ATP + EGF:ErbB1:Inh -> (EGF:ErbB1:ErbB1):Inh k2 kd2

075109
type: SpeciesReference
stoichiometry: 1.0
species: 325928

325928
type: Species
name: (EGF:ErbB1:ATP::EGF:ErbB1:Inh)
has part: P00533
boundary condition: false
initial concentration: NaN
has only substance units: true
initial amount: 0.0
has part: CHEBI:15422
constant: false
notes: (EGF:ErbB1:ATP::EGF:ErbB1:Inh) , plasma membrane
in compartment: 325898
has version: P01133

075097
type: SpeciesReference
stoichiometry: 1.0
species: 325926

075085
type: SpeciesReference
stoichiometry: 1.0
species: 325914

328059
type: Reaction
kinetic law: 100701
product: 100689
reactant: 100677
fast: false
reversible: true
name: v569 2(ErbB2)#P:GAP:(Shc#P) -> R_degraded k60b kd60

100689
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100677
type: SpeciesReference
stoichiometry: 1.0
species: 326491

328993
type: Parameter
constant: true
value: 5.91474E-7
name: k8

328263
type: Reaction
kinetic law: 105171
product: 105159
reactant: 105146
reactant: 105134
fast: false
reversible: true
name: v673 EGF:ErbB1#P + EGF:ErbB1#P -> 2(EGF:ErbB1)#P k102 kd102

105159
type: SpeciesReference
stoichiometry: 1.0
species: 326425

105146
type: SpeciesReference
stoichiometry: 1.0
species: 326777

105134
type: SpeciesReference
stoichiometry: 1.0
species: 326777

326985
type: Reaction
kinetic law: 075872
product: 075859
reactant: 075846
reactant: 075833
fast: false
reversible: true
name: v20 EGF:ErbB1:ATP + ErbB3:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b

075859
type: SpeciesReference
stoichiometry: 1.0
species: 325978

325978
type: Species
has only substance units: true
initial concentration: NaN
constant: false
initial amount: 0.0
notes: (EGF:ErbB1:ErbB3)#P:Inh , plasma membrane
name: (EGF:ErbB1:ErbB3)_P:Inh
in compartment: 325898
has part: P00533
has version: P01133
boundary condition: false

075846
type: SpeciesReference
stoichiometry: 1.0
species: 325976

075833
type: SpeciesReference
stoichiometry: 1.0
species: 325914

329235
type: Parameter
constant: true
value: 0.01
name: kd94

326279
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP

327557
type: Reaction
kinetic law: 089277
product: 089265
reactant: 089253
reactant: 089241
fast: false
reversible: true
name: v315 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089265
type: SpeciesReference
stoichiometry: 1.0
species: 326189

089253
type: SpeciesReference
stoichiometry: 1.0
species: 326547

089241
type: SpeciesReference
stoichiometry: 1.0
species: 326201

327463
type: Reaction
kinetic law: 087012
product: 087000
reactant: 086988
reactant: 086976
fast: false
reversible: true
name: v268 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087000
type: SpeciesReference
stoichiometry: 1.0
species: 326375

326375
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

086988
type: SpeciesReference
stoichiometry: 1.0
species: 326363

086976
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327237
type: Reaction
kinetic law: 081949
product: 081937
reactant: 081925
reactant: 081913
fast: false
reversible: true
name: v153 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b

081937
type: SpeciesReference
stoichiometry: 1.0
species: 326090

081925
type: SpeciesReference
stoichiometry: 1.0
species: 326405

081913
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329099
type: Parameter
constant: true
value: 0.0429
name: kd41

327603
type: Reaction
kinetic law: 090432
product: 090420
reactant: 090408
reactant: 090396
fast: false
reversible: true
name: v338 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

090420
type: SpeciesReference
stoichiometry: 1.0
species: 326313

090408
type: SpeciesReference
stoichiometry: 1.0
species: 326549

090396
type: SpeciesReference
stoichiometry: 1.0
species: 326321

329333
type: Parameter
constant: true
value: 6.57
name: kd111

326243
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP

327515
type: Reaction
kinetic law: 088263
product: 088251
reactant: 088239
reactant: 088227
fast: false
reversible: true
name: v294 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088251
type: SpeciesReference
stoichiometry: 1.0
species: 326064

088239
type: SpeciesReference
stoichiometry: 1.0
species: 326060

088227
type: SpeciesReference
stoichiometry: 1.0
species: 326543

327863
type: Reaction
kinetic law: 096512
product: 096500
reactant: 096488
reactant: 096476
fast: false
reversible: true
name: v468 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

096500
type: SpeciesReference
stoichiometry: 1.0
species: 326245

096488
type: SpeciesReference
stoichiometry: 1.0
species: 326525

096476
type: SpeciesReference
stoichiometry: 1.0
species: 326507

327451
type: Reaction
kinetic law: 086724
product: 086712
reactant: 086700
reactant: 086688
fast: false
reversible: true
name: v262 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086712
type: SpeciesReference
stoichiometry: 1.0
species: 326393

086700
type: SpeciesReference
stoichiometry: 1.0
species: 326399

086688
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328447
type: Reaction
kinetic law: 109603
product: 109591
reactant: 109579
reactant: 109567
fast: false
reversible: true
name: v765 AKT#P#P + Raf#P -> AKT:P:P:Raf:P:Ser k114 kd114

109591
type: SpeciesReference
stoichiometry: 1.0
species: 326877

109579
type: SpeciesReference
stoichiometry: 1.0
species: 326573

109567
type: SpeciesReference
stoichiometry: 1.0
species: 326747

326833
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P_ERK_PP

327327
type: Reaction
kinetic law: 083745
product: 083733
reactant: 083721
reactant: 083709
fast: false
reversible: true
name: v199 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8 kd8

083733
type: SpeciesReference
stoichiometry: 1.0
species: 326501

083721
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083709
type: SpeciesReference
stoichiometry: 1.0
species: 326461

326461
type: Species
notes: (ErbB1:ErbB2)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P

327161
type: Reaction
kinetic law: 080116
product: 080104
reactant: 080092
reactant: 080080
fast: false
reversible: true
name: v112 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b

080104
type: SpeciesReference
stoichiometry: 1.0
species: 326271

080092
type: SpeciesReference
stoichiometry: 1.0
species: 326329

326329
type: Species
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

080080
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328935
type: Parameter
constant: false
units: item
value: NaN

327915
type: Reaction
kinetic law: 097766
product: 097753
reactant: 097741
reactant: 097729
fast: false
reversible: true
name: v494 MEK#P + Raf#P -> MEK#P:Raf#P k44 kd52

097753
type: SpeciesReference
stoichiometry: 1.0
species: 326597

326597
type: Species
notes: MEK#P:Raf#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_P:Raf_P

097741
type: SpeciesReference
stoichiometry: 1.0
species: 326573

097729
type: SpeciesReference
stoichiometry: 1.0
species: 326595

328115
type: Reaction
kinetic law: 101712
product: 101700
reactant: 101688
fast: false
reversible: true
name: v599 EGF -> EGF_degraded k61 kd61

101700
type: SpeciesReference
stoichiometry: 1.0
species: 326645

101688
type: SpeciesReference
stoichiometry: 1.0
species: 326515

326515
type: Species
in compartment: 325900
notes: EGF , endosomes
constant: false
initial amount: 0.0
is: SBO:0000252
initial concentration: NaN
is version of: P01133
has only substance units: true
is version of: GO:0005154
name: EGF
boundary condition: false

328537
type: Reaction
kinetic law: 111744
product: 111732
reactant: 111720
reactant: 111708
fast: false
reversible: true
name: v811 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1):ATP k123 kd123

111732
type: SpeciesReference
stoichiometry: 1.0
species: 325988

111720
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111708
type: SpeciesReference
stoichiometry: 1.0
species: 326427

328371
type: Reaction
kinetic law: 107774
product: 107762
reactant: 107750
reactant: 107738
fast: false
reversible: true
name: v727 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110

107762
type: SpeciesReference
stoichiometry: 1.0
species: 326829

326829
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:ERK_PP

107750
type: SpeciesReference
stoichiometry: 1.0
species: 326691

107738
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327409
type: Reaction
kinetic law: 085711
product: 085699
reactant: 085687
reactant: 085675
fast: false
reversible: true
name: v241 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17

085699
type: SpeciesReference
stoichiometry: 1.0
species: 326285

085687
type: SpeciesReference
stoichiometry: 1.0
species: 326273

326273
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2

085675
type: SpeciesReference
stoichiometry: 1.0
species: 326539

325986
type: Species
notes: (EGF:ErbB1:ErbB4):ATP , cytoplasm
has part: P00533
has only substance units: true
constant: false
in compartment: 325908
initial concentration: NaN
boundary condition: false
initial amount: 0.0
has version: P01133
name: (EGF:ErbB1:ErbB4):ATP

326032
type: Species
notes: (HRG:ErbB3:ErbB1):ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (HRG:ErbB3:ErbB1):ATP

326082
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP

329109
type: Parameter
constant: true
value: 0.01833
name: kd44

327285
type: Reaction
kinetic law: 082912
product: 082900
reactant: 082888
fast: false
reversible: true
name: v178 ErbB4 -> ErbB4 k6b kd6b

082900
type: SpeciesReference
stoichiometry: 1.0
species: 325958

082888
type: SpeciesReference
stoichiometry: 1.0
species: 325946

325946
type: Species
notes: ErbB4 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 794.0
in compartment: 325898
name: ErbB4

327011
type: Reaction
kinetic law: 076499
product: 076487
reactant: 076475
reactant: 076463
fast: false
reversible: true
name: v33 2(ErbB2)#P:GAP:Grb2:Gab1 + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122

076487
type: SpeciesReference
stoichiometry: 1.0
species: 326016

076475
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076463
type: SpeciesReference
stoichiometry: 1.0
species: 326014

328969
type: Parameter
constant: true
value: 0.001
name: kd3

328235
type: Reaction
kinetic law: 104496
product: 104484
reactant: 104472
reactant: 104460
fast: false
reversible: true
name: v659 RTK_Pase + (EGF:ErbB1:ErbB4) -> (ErbB1:ErbB4)#P:RTK_Pase k95 kd95

104484
type: SpeciesReference
stoichiometry: 1.0
species: 326759

104472
type: SpeciesReference
stoichiometry: 1.0
species: 325960

325960
type: Species
boundary condition: false
initial concentration: NaN
name: (EGF:ErbB1:ErbB4)
has only substance units: true
has version: P01133
notes: (EGF:ErbB1:ErbB4) , endosomal membrane
constant: false
initial amount: 0.0
in compartment: 325906
has part: P00533

104460
type: SpeciesReference
stoichiometry: 1.0
species: 326755

327715
type: Reaction
kinetic law: 092961
product: 092949
reactant: 092937
fast: false
reversible: true
name: v394 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23

092949
type: SpeciesReference
stoichiometry: 1.0
species: 326537

092937
type: SpeciesReference
stoichiometry: 1.0
species: 326563

326563
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Shc

327105
type: Reaction
kinetic law: 078767
product: 078755
reactant: 078743
reactant: 078730
fast: false
reversible: true
name: v83 2(ErbB2)#P:GAP:Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4

078755
type: SpeciesReference
stoichiometry: 1.0
species: 326235

326235
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:cPP

078743
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078730
type: SpeciesReference
stoichiometry: 1.0
species: 326233

329079
type: Parameter
constant: true
value: 7.5E-6
name: k34

326154
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP):cPP

329381
type: Parameter
constant: true
value: 1.0
name: kd121

326130
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP

329275
type: Parameter
constant: true
value: 33300.0
name: k98

327975
type: Reaction
kinetic law: 099188
product: 099176
reactant: 099164
fast: false
reversible: true
name: v524 2(EGF:ErbB1:ATP) -> R_degraded k60 kd60

099176
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099164
type: SpeciesReference
stoichiometry: 1.0
species: 325936

328495
type: Reaction
kinetic law: 110748
product: 110736
reactant: 110724
reactant: 110712
fast: false
reversible: true
name: v789 HRG:ErbB3 + ErbB1:ATP -> (HRG:ErbB3:ErbB1) k120b kd120

110736
type: SpeciesReference
stoichiometry: 1.0
species: 326030

110724
type: SpeciesReference
stoichiometry: 1.0
species: 325912

110712
type: SpeciesReference
stoichiometry: 1.0
species: 326903

327563
type: Reaction
kinetic law: 089430
product: 089417
reactant: 089404
reactant: 089391
fast: false
reversible: true
name: v318 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089417
type: SpeciesReference
stoichiometry: 1.0
species: 326369

089404
type: SpeciesReference
stoichiometry: 1.0
species: 326363

089391
type: SpeciesReference
stoichiometry: 1.0
species: 326549

326555
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Shc

328175
type: Reaction
kinetic law: 103050
product: 103038
reactant: 103026
reactant: 103014
fast: false
reversible: true
name: v629 PIP3 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68

103038
type: SpeciesReference
stoichiometry: 1.0
species: 326711

103026
type: SpeciesReference
stoichiometry: 1.0
species: 326697

326697
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K

103014
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327375
type: Reaction
kinetic law: 084890
product: 084878
reactant: 084866
reactant: 084854
fast: false
reversible: true
name: v224 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24

084878
type: SpeciesReference
stoichiometry: 1.0
species: 326092

084866
type: SpeciesReference
stoichiometry: 1.0
species: 326529

084854
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328329
type: Reaction
kinetic law: 106762
product: 106750
reactant: 106738
reactant: 106726
fast: false
reversible: true
name: v706 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k106 kd106

106750
type: SpeciesReference
stoichiometry: 1.0
species: 326729

326729
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)6

106738
type: SpeciesReference
stoichiometry: 1.0
species: 326727

106726
type: SpeciesReference
stoichiometry: 1.0
species: 326793

326295
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP

327469
type: Reaction
kinetic law: 087157
product: 087145
reactant: 087133
reactant: 087121
fast: false
reversible: true
name: v271 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

087145
type: SpeciesReference
stoichiometry: 1.0
species: 326221

087133
type: SpeciesReference
stoichiometry: 1.0
species: 326217

087121
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328163
type: Reaction
kinetic law: 102760
product: 102748
reactant: 102736
reactant: 102724
fast: false
reversible: true
name: v623 PI3K + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66

102748
type: SpeciesReference
stoichiometry: 1.0
species: 326689

102736
type: SpeciesReference
stoichiometry: 1.0
species: 326687

102724
type: SpeciesReference
stoichiometry: 1.0
species: 326677

327839
type: Reaction
kinetic law: 095934
product: 095922
reactant: 095910
reactant: 095898
fast: false
reversible: true
name: v456 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37

095922
type: SpeciesReference
stoichiometry: 1.0
species: 326096

326096
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2

095910
type: SpeciesReference
stoichiometry: 1.0
species: 326525

095898
type: SpeciesReference
stoichiometry: 1.0
species: 326505

327079
type: Reaction
kinetic law: 078142
product: 078130
reactant: 078118
reactant: 078106
fast: false
reversible: true
name: v68 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4

078130
type: SpeciesReference
stoichiometry: 1.0
species: 326154

078118
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078106
type: SpeciesReference
stoichiometry: 1.0
species: 326152

327427
type: Reaction
kinetic law: 086147
product: 086135
reactant: 086123
reactant: 086111
fast: false
reversible: true
name: v250 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17

086135
type: SpeciesReference
stoichiometry: 1.0
species: 326205

326205
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos

086123
type: SpeciesReference
stoichiometry: 1.0
species: 326140

086111
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326761
type: Species
notes: 2(EGF:ErbB1)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:RTK_Pase

328585
type: Reaction
kinetic law: 112939
product: 112927
reactant: 112915
reactant: 112903
fast: false
reversible: true
name: v855 EGF:ErbB1:ATP::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k122 kd122

112927
type: SpeciesReference
stoichiometry: 1.0
species: 326939

112915
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112903
type: SpeciesReference
stoichiometry: 1.0
species: 326929

329111
type: Parameter
constant: true
value: 1.9
name: kd45

327457
type: Reaction
kinetic law: 086868
product: 086856
reactant: 086844
reactant: 086832
fast: false
reversible: true
name: v265 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

086856
type: SpeciesReference
stoichiometry: 1.0
species: 326148

086844
type: SpeciesReference
stoichiometry: 1.0
species: 326201

086832
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327123
type: Reaction
kinetic law: 079201
product: 079189
reactant: 079176
reactant: 079164
fast: false
reversible: true
name: v93 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4

079189
type: SpeciesReference
stoichiometry: 1.0
species: 326271

079176
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079164
type: SpeciesReference
stoichiometry: 1.0
species: 326269

326979
type: Reaction
kinetic law: 075714
product: 075701
reactant: 075688
reactant: 075675
fast: false
reversible: true
name: v17 ErbB4 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB4 k2b kd2b

075701
type: SpeciesReference
stoichiometry: 1.0
species: 325966

325966
type: Species
has version: P01133
constant: false
in compartment: 325898
initial concentration: NaN
boundary condition: false
notes: EGF:ErbB1:Inh:ErB4 , plasma membrane
has part: P00533
initial amount: 0.0
has only substance units: true
name: EGF:ErbB1:Inh:ErB4

075688
type: SpeciesReference
stoichiometry: 1.0
species: 325926

075675
type: SpeciesReference
stoichiometry: 1.0
species: 325946

328403
type: Reaction
kinetic law: 108544
product: 108532
reactant: 108520
reactant: 108508
fast: false
reversible: true
name: v743 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111

108532
type: SpeciesReference
stoichiometry: 1.0
species: 326829

108520
type: SpeciesReference
stoichiometry: 1.0
species: 326855

326855
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P

108508
type: SpeciesReference
stoichiometry: 1.0
species: 326627

329157
type: Parameter
constant: true
value: 0.00266742
name: k60

327763
type: Reaction
kinetic law: 094117
product: 094105
reactant: 094093
reactant: 094081
fast: false
reversible: true
name: v418 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094105
type: SpeciesReference
stoichiometry: 1.0
species: 326399

094093
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094081
type: SpeciesReference
stoichiometry: 1.0
species: 326495

326066
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP):cPP

327501
type: Reaction
kinetic law: 087926
product: 087914
reactant: 087902
reactant: 087890
fast: false
reversible: true
name: v287 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

087914
type: SpeciesReference
stoichiometry: 1.0
species: 326237

087902
type: SpeciesReference
stoichiometry: 1.0
species: 326233

087890
type: SpeciesReference
stoichiometry: 1.0
species: 326543

329297
type: Parameter
notes: %receptor dimerization ErbB2/3
constant: false
value: 8.36983E-9
name: k103

327291
type: Reaction
kinetic law: 083021
product: 083009
reactant: 082997
fast: false
reversible: true
name: v181 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k6b kd6b

083009
type: SpeciesReference
stoichiometry: 1.0
species: 326451

082997
type: SpeciesReference
stoichiometry: 1.0
species: 326449

329391
type: Parameter
constant: false
value: 0.0
name: k1

327487
type: Reaction
kinetic law: 087590
product: 087578
reactant: 087566
reactant: 087554
fast: false
reversible: true
name: v280 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087578
type: SpeciesReference
stoichiometry: 1.0
species: 326315

087566
type: SpeciesReference
stoichiometry: 1.0
species: 326319

326319
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos

087554
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329031
type: Parameter
constant: true
value: 1.667E-7
name: k19

326335
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

327691
type: Reaction
kinetic law: 092527
product: 092515
reactant: 092503
fast: false
reversible: true
name: v382 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23

092515
type: SpeciesReference
stoichiometry: 1.0
species: 326451

092503
type: SpeciesReference
stoichiometry: 1.0
species: 326443

326443
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Shc

327627
type: Reaction
kinetic law: 091012
product: 091000
reactant: 090988
reactant: 090976
fast: false
reversible: true
name: v350 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

091000
type: SpeciesReference
stoichiometry: 1.0
species: 326387

090988
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090976
type: SpeciesReference
stoichiometry: 1.0
species: 326399

329357
type: Parameter
constant: true
value: 8.33E-8
name: k117

327017
type: Reaction
kinetic law: 076644
product: 076631
reactant: 076619
reactant: 076607
fast: false
reversible: true
name: v36 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k122 kd122

076631
type: SpeciesReference
stoichiometry: 1.0
species: 326028

076619
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076607
type: SpeciesReference
stoichiometry: 1.0
species: 326026

326026
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1

327539
type: Reaction
kinetic law: 088844
product: 088832
reactant: 088820
reactant: 088808
fast: false
reversible: true
name: v306 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088832
type: SpeciesReference
stoichiometry: 1.0
species: 326371

088820
type: SpeciesReference
stoichiometry: 1.0
species: 326545

088808
type: SpeciesReference
stoichiometry: 1.0
species: 326359

327155
type: Reaction
kinetic law: 079972
product: 079960
reactant: 079948
reactant: 079936
fast: false
reversible: true
name: v109 cPP + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k5b kd5b

079960
type: SpeciesReference
stoichiometry: 1.0
species: 326283

326283
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:cPP

079948
type: SpeciesReference
stoichiometry: 1.0
species: 326323

326323
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2

079936
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327887
type: Reaction
kinetic law: 097089
product: 097077
reactant: 097065
reactant: 097053
fast: false
reversible: true
name: v480 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097077
type: SpeciesReference
stoichiometry: 1.0
species: 326395

097065
type: SpeciesReference
stoichiometry: 1.0
species: 326537

097053
type: SpeciesReference
stoichiometry: 1.0
species: 326577

327241
type: Reaction
kinetic law: 082045
product: 082033
reactant: 082021
reactant: 082009
fast: false
reversible: true
name: v156 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5

082033
type: SpeciesReference
stoichiometry: 1.0
species: 326082

082021
type: SpeciesReference
stoichiometry: 1.0
species: 326409

326409
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

082009
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328051
type: Reaction
kinetic law: 100557
product: 100545
reactant: 100533
fast: false
reversible: true
name: v565 (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> R_degraded k60b kd60

100545
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100533
type: SpeciesReference
stoichiometry: 1.0
species: 326359

327185
type: Reaction
kinetic law: 080691
product: 080680
reactant: 080668
reactant: 080656
fast: false
reversible: true
name: v125 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b

080680
type: SpeciesReference
stoichiometry: 1.0
species: 326223

080668
type: SpeciesReference
stoichiometry: 1.0
species: 326353

080656
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328959
type: Parameter
constant: true
value: 7.44622E-6
name: k2

327939
type: Reaction
kinetic law: 098344
product: 098332
reactant: 098320
reactant: 098308
fast: false
reversible: true
name: v506 Pase2 + MEK#P -> MEK#P:Pase2 k50 kd50

098332
type: SpeciesReference
stoichiometry: 1.0
species: 326609

098320
type: SpeciesReference
stoichiometry: 1.0
species: 326595

098308
type: SpeciesReference
stoichiometry: 1.0
species: 326603

328365
type: Reaction
kinetic law: 107630
product: 107618
reactant: 107605
reactant: 107593
fast: false
reversible: true
name: v724 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k110 kd110

107618
type: SpeciesReference
stoichiometry: 1.0
species: 326823

107605
type: SpeciesReference
stoichiometry: 1.0
species: 326679

107593
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328139
type: Reaction
kinetic law: 102182
product: 102170
reactant: 102158
reactant: 102146
fast: false
reversible: true
name: v611 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k64 kd64

102170
type: SpeciesReference
stoichiometry: 1.0
species: 326659

326659
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:ERK_PP

102158
type: SpeciesReference
stoichiometry: 1.0
species: 326076

102146
type: SpeciesReference
stoichiometry: 1.0
species: 326627

329231
type: Parameter
constant: true
value: 5.0E-5
name: k94b

329121
type: Parameter
constant: false
value: 0.79
name: kd48

329061
type: Parameter
constant: true
value: 5.0E-6
name: k28b

326905
type: Species
notes: HRG:ErbB4 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: HRG:ErbB4

328451
type: Reaction
kinetic law: 109699
product: 109687
reactant: 109675
reactant: 109663
fast: false
reversible: true
name: v767 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser k115 kd115

109687
type: SpeciesReference
stoichiometry: 1.0
species: 326877

109675
type: SpeciesReference
stoichiometry: 1.0
species: 326747

109663
type: SpeciesReference
stoichiometry: 1.0
species: 326881

326881
type: Species
notes: Raf:P:Ser , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: Raf:P:Ser

328395
type: Reaction
kinetic law: 108352
product: 108339
reactant: 108327
reactant: 108315
fast: false
reversible: true
name: v739 ERK#P#P + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111

108339
type: SpeciesReference
stoichiometry: 1.0
species: 326837

108327
type: SpeciesReference
stoichiometry: 1.0
species: 326851

108315
type: SpeciesReference
stoichiometry: 1.0
species: 326627

328503
type: Reaction
kinetic law: 110940
product: 110928
reactant: 110916
reactant: 110904
fast: false
reversible: true
name: v793 ErbB1:ATP + (HRG:ErbB4) -> (HRG:ErbB4:ErbB1) k120b kd120

110928
type: SpeciesReference
stoichiometry: 1.0
species: 326649

110916
type: SpeciesReference
stoichiometry: 1.0
species: 326907

110904
type: SpeciesReference
stoichiometry: 1.0
species: 326423

327709
type: Reaction
kinetic law: 092853
product: 092841
reactant: 092829
fast: false
reversible: true
name: v391 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23

092841
type: SpeciesReference
stoichiometry: 1.0
species: 326531

092829
type: SpeciesReference
stoichiometry: 1.0
species: 326557

326557
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Shc

327599
type: Reaction
kinetic law: 090336
product: 090324
reactant: 090312
reactant: 090300
fast: false
reversible: true
name: v336 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

090324
type: SpeciesReference
stoichiometry: 1.0
species: 326311

090312
type: SpeciesReference
stoichiometry: 1.0
species: 326549

090300
type: SpeciesReference
stoichiometry: 1.0
species: 326319

326561
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Shc

327965
type: Reaction
kinetic law: 098970
product: 098958
reactant: 098946
reactant: 098934
fast: false
reversible: true
name: v519 ERK + Pase3 -> ERK#P:Pase3 k57 kd57

098958
type: SpeciesReference
stoichiometry: 1.0
species: 326637

098946
type: SpeciesReference
stoichiometry: 1.0
species: 326631

098934
type: SpeciesReference
stoichiometry: 1.0
species: 326613

327739
type: Reaction
kinetic law: 093536
product: 093524
reactant: 093512
reactant: 093500
fast: false
reversible: true
name: v406 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093524
type: SpeciesReference
stoichiometry: 1.0
species: 326337

093512
type: SpeciesReference
stoichiometry: 1.0
species: 326339

093500
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328485
type: Reaction
kinetic law: 110508
product: 110496
reactant: 110484
reactant: 110472
fast: false
reversible: true
name: v784 HRG + ErbB3 -> HRG:ErbB3 k119 kd119

110496
type: SpeciesReference
stoichiometry: 1.0
species: 326903

110484
type: SpeciesReference
stoichiometry: 1.0
species: 325942

110472
type: SpeciesReference
stoichiometry: 1.0
species: 326901

326901
type: Species
boundary condition: true
substance units: mole
notes: HRG , medium
in compartment: 325904
name: HRG
initial concentration: 0.0
constant: false
has only substance units: false
initial amount: NaN

328259
type: Reaction
kinetic law: 105073
product: 105061
reactant: 105049
reactant: 105037
fast: false
reversible: true
name: v671 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101

105061
type: SpeciesReference
stoichiometry: 1.0
species: 326669

105049
type: SpeciesReference
stoichiometry: 1.0
species: 326072

105037
type: SpeciesReference
stoichiometry: 1.0
species: 326671

326671
type: Species
notes: Sos#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Sos_P

327413
type: Reaction
kinetic law: 085808
product: 085796
reactant: 085784
reactant: 085772
fast: false
reversible: true
name: v243 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17

085796
type: SpeciesReference
stoichiometry: 1.0
species: 326289

085784
type: SpeciesReference
stoichiometry: 1.0
species: 326281

085772
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326731
type: Species
constant: false
initial concentration: NaN
boundary condition: false
initial amount: 905000.0
in compartment: 325908
is version of: P31749
notes: AKT , cytoplasm
has only substance units: true
name: AKT

327587
type: Reaction
kinetic law: 090047
product: 090035
reactant: 090022
reactant: 090010
fast: false
reversible: true
name: v330 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

090035
type: SpeciesReference
stoichiometry: 1.0
species: 326383

326383
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

090022
type: SpeciesReference
stoichiometry: 1.0
species: 326395

090010
type: SpeciesReference
stoichiometry: 1.0
species: 326549

327023
type: Reaction
kinetic law: 076789
product: 076777
reactant: 076765
reactant: 076753
fast: false
reversible: true
name: v39 (HRG:ErbB4):ErbB2 + ATP -> (HRG:ErbB4):ErbB2:ATP k122 kd122

076777
type: SpeciesReference
stoichiometry: 1.0
species: 326040

076765
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076753
type: SpeciesReference
stoichiometry: 1.0
species: 326038

326663
type: Species
notes: (ERK#P#P):Sos , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_PP):Sos

327399
type: Reaction
kinetic law: 085470
product: 085458
reactant: 085446
reactant: 085434
fast: false
reversible: true
name: v236 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

085458
type: SpeciesReference
stoichiometry: 1.0
species: 326339

085446
type: SpeciesReference
stoichiometry: 1.0
species: 326459

085434
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328303
type: Reaction
kinetic law: 106136
product: 106124
reactant: 106111
reactant: 106099
fast: false
reversible: true
name: v693 (ErbB3:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105

106124
type: SpeciesReference
stoichiometry: 1.0
species: 326018

106111
type: SpeciesReference
stoichiometry: 1.0
species: 326801

106099
type: SpeciesReference
stoichiometry: 1.0
species: 326273

327663
type: Reaction
kinetic law: 091878
product: 091866
reactant: 091854
reactant: 091842
fast: false
reversible: true
name: v368 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22

091866
type: SpeciesReference
stoichiometry: 1.0
species: 326435

091854
type: SpeciesReference
stoichiometry: 1.0
species: 326431

091842
type: SpeciesReference
stoichiometry: 1.0
species: 326551

328231
type: Reaction
kinetic law: 104399
product: 104387
reactant: 104375
reactant: 104363
fast: false
reversible: true
name: v657 RTK_Pase + (EGF:ErbB1:ErbB2) -> (ErbB1:ErbB2)#P:RTK_Pase k95 kd95

104387
type: SpeciesReference
stoichiometry: 1.0
species: 326769

326769
type: Species
notes: (ErbB1:ErbB2)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:RTK_Pase

104375
type: SpeciesReference
stoichiometry: 1.0
species: 325952

104363
type: SpeciesReference
stoichiometry: 1.0
species: 326755

329203
type: Parameter
notes: %10.5
constant: true
value: 5.01187
name: kd72

327757
type: Reaction
kinetic law: 093973
product: 093961
reactant: 093948
reactant: 093936
fast: false
reversible: true
name: v415 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

093961
type: SpeciesReference
stoichiometry: 1.0
species: 326100

093948
type: SpeciesReference
stoichiometry: 1.0
species: 326575

093936
type: SpeciesReference
stoichiometry: 1.0
species: 326501

327147
type: Reaction
kinetic law: 079780
product: 079768
reactant: 079756
reactant: 079744
fast: false
reversible: true
name: v105 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b

079768
type: SpeciesReference
stoichiometry: 1.0
species: 326299

079756
type: SpeciesReference
stoichiometry: 1.0
species: 326315

079744
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328277
type: Reaction
kinetic law: 105509
product: 105497
reactant: 105485
reactant: 105473
fast: false
reversible: true
name: v680 ErbB2#P + ErbB3#P -> (ErbB3:ErbB2)#P k103 kd103

105497
type: SpeciesReference
stoichiometry: 1.0
species: 325918

105485
type: SpeciesReference
stoichiometry: 1.0
species: 326779

105473
type: SpeciesReference
stoichiometry: 1.0
species: 326771

326771
type: Species
notes: ErbB2#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB2_P

328015
type: Reaction
kinetic law: 099908
product: 099896
reactant: 099884
fast: false
reversible: true
name: v545 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60

099896
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099884
type: SpeciesReference
stoichiometry: 1.0
species: 326395

327787
type: Reaction
kinetic law: 094695
product: 094683
reactant: 094671
reactant: 094659
fast: false
reversible: true
name: v430 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34

094683
type: SpeciesReference
stoichiometry: 1.0
species: 326201

094671
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094659
type: SpeciesReference
stoichiometry: 1.0
species: 326501

329301
type: Parameter
constant: true
value: 0.0
name: k104

328321
type: Reaction
kinetic law: 106570
product: 106558
reactant: 106546
reactant: 106534
fast: false
reversible: true
name: v702 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k106 kd106

106558
type: SpeciesReference
stoichiometry: 1.0
species: 326721

106546
type: SpeciesReference
stoichiometry: 1.0
species: 326709

106534
type: SpeciesReference
stoichiometry: 1.0
species: 326793

327831
type: Reaction
kinetic law: 095741
product: 095729
reactant: 095717
reactant: 095705
fast: false
reversible: true
name: v452 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37

095729
type: SpeciesReference
stoichiometry: 1.0
species: 326535

095717
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095705
type: SpeciesReference
stoichiometry: 1.0
species: 326497

326497
type: Species
notes: (ErbB1:ErbB3)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP

327071
type: Reaction
kinetic law: 077949
product: 077937
reactant: 077925
reactant: 077913
fast: false
reversible: true
name: v64 (ErbB1:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k4b kd4

077937
type: SpeciesReference
stoichiometry: 1.0
species: 326138

077925
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077913
type: SpeciesReference
stoichiometry: 1.0
species: 326136

328351
type: Reaction
kinetic law: 107291
product: 107279
reactant: 107267
reactant: 107255
fast: false
reversible: true
name: v717 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108

107279
type: SpeciesReference
stoichiometry: 1.0
species: 326813

107267
type: SpeciesReference
stoichiometry: 1.0
species: 326014

107255
type: SpeciesReference
stoichiometry: 1.0
species: 326805

329055
type: Parameter
constant: true
value: 0.0214
name: kd25

327877
type: Reaction
kinetic law: 096848
product: 096836
reactant: 096824
reactant: 096812
fast: false
reversible: true
name: v475 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

096836
type: SpeciesReference
stoichiometry: 1.0
species: 326100

096824
type: SpeciesReference
stoichiometry: 1.0
species: 326527

326527
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P)

096812
type: SpeciesReference
stoichiometry: 1.0
species: 326577

327231
type: Reaction
kinetic law: 081805
product: 081793
reactant: 081781
reactant: 081769
fast: false
reversible: true
name: v150 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b

081793
type: SpeciesReference
stoichiometry: 1.0
species: 326102

326102
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP

081781
type: SpeciesReference
stoichiometry: 1.0
species: 326399

081769
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327179
type: Reaction
kinetic law: 080548
product: 080536
reactant: 080524
reactant: 080512
fast: false
reversible: true
name: v122 cPP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b

080536
type: SpeciesReference
stoichiometry: 1.0
species: 326235

080524
type: SpeciesReference
stoichiometry: 1.0
species: 326347

080512
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327929
type: Reaction
kinetic law: 098103
product: 098091
reactant: 098079
reactant: 098067
fast: false
reversible: true
name: v501 MEK#P + Pase2 -> MEK#P#P:Pase2 k49 kd49

098091
type: SpeciesReference
stoichiometry: 1.0
species: 326607

326607
type: Species
notes: MEK#P#P:Pase2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP:Pase2

098079
type: SpeciesReference
stoichiometry: 1.0
species: 326603

098067
type: SpeciesReference
stoichiometry: 1.0
species: 326595

326971
type: Reaction
kinetic law: 075506
product: 075494
reactant: 075482
reactant: 075470
fast: false
reversible: true
name: v13 EGF:ErbB1:ATP + ErbB3 -> (EGF:ErbB1:ErbB3) k2b kd2b

075494
type: SpeciesReference
stoichiometry: 1.0
species: 325956

075482
type: SpeciesReference
stoichiometry: 1.0
species: 325954

075470
type: SpeciesReference
stoichiometry: 1.0
species: 325934

327491
type: Reaction
kinetic law: 087686
product: 087674
reactant: 087662
reactant: 087650
fast: false
reversible: true
name: v282 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087674
type: SpeciesReference
stoichiometry: 1.0
species: 326317

087662
type: SpeciesReference
stoichiometry: 1.0
species: 326321

087650
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328075
type: Reaction
kinetic law: 100989
product: 100977
reactant: 100965
fast: false
reversible: true
name: v579 (ErbB3:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60

100977
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100965
type: SpeciesReference
stoichiometry: 1.0
species: 326443

327639
type: Reaction
kinetic law: 091300
product: 091288
reactant: 091276
reactant: 091264
fast: false
reversible: true
name: v356 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091288
type: SpeciesReference
stoichiometry: 1.0
species: 326369

091276
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091264
type: SpeciesReference
stoichiometry: 1.0
species: 326363

327029
type: Reaction
kinetic law: 076935
product: 076923
reactant: 076911
reactant: 076899
fast: false
reversible: true
name: v42 (HRG:ErbB4):ErbB2) + ATP -> (HRG:ErbB4):ErbB2):ATP k122 kd122

076923
type: SpeciesReference
stoichiometry: 1.0
species: 326052

326052
type: Species
notes: ((HRG:ErbB4):ErbB2):ATP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ((HRG:ErbB4):ErbB2):ATP

076911
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076899
type: SpeciesReference
stoichiometry: 1.0
species: 326050

328441
type: Reaction
kinetic law: 109459
product: 109447
reactant: 109435
reactant: 109423
fast: false
reversible: true
name: v762 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113

109447
type: SpeciesReference
stoichiometry: 1.0
species: 326871

109435
type: SpeciesReference
stoichiometry: 1.0
species: 326697

109423
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328215
type: Reaction
kinetic law: 104012
product: 104000
reactant: 103988
reactant: 103976
fast: false
reversible: true
name: v649 PDK1 + PIP3 -> PIP3:PDK1 k76 kd76

104000
type: SpeciesReference
stoichiometry: 1.0
species: 326745

103988
type: SpeciesReference
stoichiometry: 1.0
species: 326707

103976
type: SpeciesReference
stoichiometry: 1.0
species: 326739

328389
type: Reaction
kinetic law: 108206
product: 108194
reactant: 108182
reactant: 108170
fast: false
reversible: true
name: v736 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110

108194
type: SpeciesReference
stoichiometry: 1.0
species: 326847

326847
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i

108182
type: SpeciesReference
stoichiometry: 1.0
species: 326703

108170
type: SpeciesReference
stoichiometry: 1.0
species: 326629

327543
type: Reaction
kinetic law: 088940
product: 088928
reactant: 088916
reactant: 088904
fast: false
reversible: true
name: v308 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088928
type: SpeciesReference
stoichiometry: 1.0
species: 326335

088916
type: SpeciesReference
stoichiometry: 1.0
species: 326325

088904
type: SpeciesReference
stoichiometry: 1.0
species: 326545

328975
type: Parameter
constant: true
value: 0.0
name: k4b

329085
type: Parameter
constant: true
value: 0.005
name: k36

326215
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:cPP

329217
type: Parameter
constant: true
value: 0.0
name: k76

327299
type: Reaction
kinetic law: 083167
product: 083155
reactant: 083143
fast: false
reversible: true
name: v185 (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P k7 kd7

083155
type: SpeciesReference
stoichiometry: 1.0
species: 326463

326463
type: Species
notes: (ErbB1:ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P

083143
type: SpeciesReference
stoichiometry: 1.0
species: 326461

328143
type: Reaction
kinetic law: 102278
product: 102266
reactant: 102254
reactant: 102242
fast: false
reversible: true
name: v613 ERK#P#P + Sos -> (ERK#P#P):Sos k64 kd64

102266
type: SpeciesReference
stoichiometry: 1.0
species: 326663

102254
type: SpeciesReference
stoichiometry: 1.0
species: 326539

102242
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327793
type: Reaction
kinetic law: 094839
product: 094827
reactant: 094815
reactant: 094803
fast: false
reversible: true
name: v433 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34

094827
type: SpeciesReference
stoichiometry: 1.0
species: 326363

094815
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094803
type: SpeciesReference
stoichiometry: 1.0
species: 326495

326887
type: Species
notes: 2(EGF:ErbB1):Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1):Gab1_P#:Pase9t

329311
type: Parameter
constant: true
value: 0.1
name: kd106

327989
type: Reaction
kinetic law: 099440
product: 099428
reactant: 099416
fast: false
reversible: true
name: v531 2(EGF:ErbB1)#P:GAP:(Shc#P) -> R_degraded k60 kd60

099428
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099416
type: SpeciesReference
stoichiometry: 1.0
species: 326439

328189
type: Reaction
kinetic law: 103387
product: 103375
reactant: 103363
reactant: 103351
fast: false
reversible: true
name: v636 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k68 kd68b

103375
type: SpeciesReference
stoichiometry: 1.0
species: 326725

103363
type: SpeciesReference
stoichiometry: 1.0
species: 326723

103351
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327343
type: Reaction
kinetic law: 084132
product: 084119
reactant: 084107
reactant: 084095
fast: false
reversible: true
name: v207 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8

084119
type: SpeciesReference
stoichiometry: 1.0
species: 326481

084107
type: SpeciesReference
stoichiometry: 1.0
species: 326493

084095
type: SpeciesReference
stoichiometry: 1.0
species: 326473

327931
type: Reaction
kinetic law: 098151
product: 098139
reactant: 098127
reactant: 098115
fast: false
reversible: true
name: v502 MEK + Pase2 -> MEK#P:Pase2 k49 kd49

098139
type: SpeciesReference
stoichiometry: 1.0
species: 326609

098127
type: SpeciesReference
stoichiometry: 1.0
species: 326603

098115
type: SpeciesReference
stoichiometry: 1.0
species: 326589

328093
type: Reaction
kinetic law: 101314
product: 101302
reactant: 101290
fast: false
reversible: true
name: v588 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60

101302
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101290
type: SpeciesReference
stoichiometry: 1.0
species: 326329

327657
type: Reaction
kinetic law: 091734
product: 091722
reactant: 091710
reactant: 091698
fast: false
reversible: true
name: v365 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091722
type: SpeciesReference
stoichiometry: 1.0
species: 326305

091710
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091698
type: SpeciesReference
stoichiometry: 1.0
species: 326289

327047
type: Reaction
kinetic law: 077369
product: 077357
reactant: 077345
reactant: 077333
fast: false
reversible: true
name: v52 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4

077357
type: SpeciesReference
stoichiometry: 1.0
species: 326090

077345
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077333
type: SpeciesReference
stoichiometry: 1.0
species: 326088

327743
type: Reaction
kinetic law: 093632
product: 093620
reactant: 093608
reactant: 093596
fast: false
reversible: true
name: v408 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093620
type: SpeciesReference
stoichiometry: 1.0
species: 326325

093608
type: SpeciesReference
stoichiometry: 1.0
species: 326341

093596
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328553
type: Reaction
kinetic law: 112144
product: 112131
reactant: 112118
reactant: 112105
fast: false
reversible: true
name: v819 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123

112131
type: SpeciesReference
stoichiometry: 1.0
species: 326020

326020
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1:ATP

112118
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112105
type: SpeciesReference
stoichiometry: 1.0
species: 326699

328327
type: Reaction
kinetic law: 106714
product: 106702
reactant: 106690
reactant: 106678
fast: false
reversible: true
name: v705 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k106 kd106

106702
type: SpeciesReference
stoichiometry: 1.0
species: 326727

106690
type: SpeciesReference
stoichiometry: 1.0
species: 326725

106678
type: SpeciesReference
stoichiometry: 1.0
species: 326793

327687
type: Reaction
kinetic law: 092455
product: 092443
reactant: 092431
reactant: 092419
fast: false
reversible: true
name: v380 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22

092443
type: SpeciesReference
stoichiometry: 1.0
species: 326447

092431
type: SpeciesReference
stoichiometry: 1.0
species: 326513

092419
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327207
type: Reaction
kinetic law: 081221
product: 081209
reactant: 081197
reactant: 081185
fast: false
reversible: true
name: v138 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b

081209
type: SpeciesReference
stoichiometry: 1.0
species: 326150

326150
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP

081197
type: SpeciesReference
stoichiometry: 1.0
species: 326375

081185
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327701
type: Reaction
kinetic law: 092709
product: 092697
reactant: 092685
fast: false
reversible: true
name: v387 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23

092697
type: SpeciesReference
stoichiometry: 1.0
species: 326439

092685
type: SpeciesReference
stoichiometry: 1.0
species: 326435

329125
type: Parameter
constant: true
value: 0.0
name: k49

328221
type: Reaction
kinetic law: 104156
product: 104144
reactant: 104132
reactant: 104120
fast: false
reversible: true
name: v652 RTK_Pase + 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P:RTK_Pase k94 kd94

104144
type: SpeciesReference
stoichiometry: 1.0
species: 326761

104132
type: SpeciesReference
stoichiometry: 1.0
species: 326427

104120
type: SpeciesReference
stoichiometry: 1.0
species: 326755

326947
type: Reaction
kinetic law: 074927
product: 074915
reactant: 074902
reactant: 074890
fast: false
reversible: true
name: v1 EGF + ErbB1:ATP -> EGF:ErbB1:ATP k1 kd1

074915
type: SpeciesReference
stoichiometry: 1.0
species: 325914

074902
type: SpeciesReference
stoichiometry: 1.0
species: 325912

074890
type: SpeciesReference
stoichiometry: 1.0
species: 325910

329019
type: Parameter
constant: true
value: 1.67E-5
name: k16

328481
type: Reaction
kinetic law: 110411
product: 110399
reactant: 110387
reactant: 110375
fast: false
reversible: true
name: v782 Pase9t + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB1:ErbB:Gab1#P##:Pase9t k118 kd118

110399
type: SpeciesReference
stoichiometry: 1.0
species: 326897

326897
type: Species
notes: ErbB1:ErbB:Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1:ErbB:Gab1_P#:Pase9t

110387
type: SpeciesReference
stoichiometry: 1.0
species: 326687

110375
type: SpeciesReference
stoichiometry: 1.0
species: 326885

328417
type: Reaction
kinetic law: 108881
product: 108868
reactant: 108856
reactant: 108844
fast: false
reversible: true
name: v750 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111

108868
type: SpeciesReference
stoichiometry: 1.0
species: 326847

108856
type: SpeciesReference
stoichiometry: 1.0
species: 326861

108844
type: SpeciesReference
stoichiometry: 1.0
species: 326629

329227
type: Parameter
constant: true
value: 0.1
name: kd34b

328039
type: Reaction
kinetic law: 100340
product: 100328
reactant: 100316
fast: false
reversible: true
name: v557 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

100328
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100316
type: SpeciesReference
stoichiometry: 1.0
species: 326371

329197
type: Parameter
constant: true
value: 0.0
name: k71

329325
type: Parameter
constant: true
value: 5.0E-6
name: k109

327391
type: Reaction
kinetic law: 085278
product: 085266
reactant: 085254
reactant: 085242
fast: false
reversible: true
name: v232 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63

085266
type: SpeciesReference
stoichiometry: 1.0
species: 326349

085254
type: SpeciesReference
stoichiometry: 1.0
species: 326521

085242
type: SpeciesReference
stoichiometry: 1.0
species: 326483

327769
type: Reaction
kinetic law: 094261
product: 094249
reactant: 094237
reactant: 094225
fast: false
reversible: true
name: v421 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094249
type: SpeciesReference
stoichiometry: 1.0
species: 326217

094237
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094225
type: SpeciesReference
stoichiometry: 1.0
species: 326481

327507
type: Reaction
kinetic law: 088070
product: 088058
reactant: 088046
reactant: 088034
fast: false
reversible: true
name: v290 (Ras:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088058
type: SpeciesReference
stoichiometry: 1.0
species: 326353

088046
type: SpeciesReference
stoichiometry: 1.0
species: 326355

088034
type: SpeciesReference
stoichiometry: 1.0
species: 326545

328345
type: Reaction
kinetic law: 107147
product: 107135
reactant: 107123
reactant: 107111
fast: false
reversible: true
name: v714 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108

107135
type: SpeciesReference
stoichiometry: 1.0
species: 326807

326807
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2

107123
type: SpeciesReference
stoichiometry: 1.0
species: 326002

326002
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1

107111
type: SpeciesReference
stoichiometry: 1.0
species: 326805

327095
type: Reaction
kinetic law: 078526
product: 078514
reactant: 078502
reactant: 078490
fast: false
reversible: true
name: v78 2(ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4

078514
type: SpeciesReference
stoichiometry: 1.0
species: 326215

078502
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078490
type: SpeciesReference
stoichiometry: 1.0
species: 326213

327443
type: Reaction
kinetic law: 086532
product: 086520
reactant: 086508
reactant: 086496
fast: false
reversible: true
name: v258 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086520
type: SpeciesReference
stoichiometry: 1.0
species: 326409

086508
type: SpeciesReference
stoichiometry: 1.0
species: 326411

086496
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327255
type: Reaction
kinetic law: 082370
product: 082358
reactant: 082346
fast: false
reversible: true
name: v163 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k6 kd6

082358
type: SpeciesReference
stoichiometry: 1.0
species: 326417

082346
type: SpeciesReference
stoichiometry: 1.0
species: 326064

328107
type: Reaction
kinetic law: 101567
product: 101555
reactant: 101543
fast: false
reversible: true
name: v595 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60

101555
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101543
type: SpeciesReference
stoichiometry: 1.0
species: 326317

329283
type: Parameter
constant: true
value: 0.001
name: Kinh3

328209
type: Reaction
kinetic law: 103868
product: 103856
reactant: 103844
reactant: 103832
fast: false
reversible: true
name: v646 AKT#P + Pase4 -> AKT#P:Pase4 k73 kd73

103856
type: SpeciesReference
stoichiometry: 1.0
species: 326753

326753
type: Species
notes: AKT#P:Pase4 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT_P:Pase4

103844
type: SpeciesReference
stoichiometry: 1.0
species: 326749

103832
type: SpeciesReference
stoichiometry: 1.0
species: 326735

326995
type: Reaction
kinetic law: 076115
product: 076103
reactant: 076091
reactant: 076079
fast: false
reversible: true
name: v25 2(EGF:ErbB1:ATP)) + ATP -> k122 kd122

076103
type: SpeciesReference
stoichiometry: 1.0
species: 325990

076091
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076079
type: SpeciesReference
stoichiometry: 1.0
species: 325932

325932
type: Species
has part: CHEBI:15422
in compartment: 325898
notes: 2(EGF:ErbB1:ATP) , plasma membrane
constant: false
has part: P00533
has version: P01133
boundary condition: false
initial concentration: NaN
has only substance units: true
name: 2(EGF:ErbB1:ATP)
initial amount: 0.0

327719
type: Reaction
kinetic law: 093056
product: 093044
reactant: 093032
reactant: 093020
fast: false
reversible: true
name: v396 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093044
type: SpeciesReference
stoichiometry: 1.0
species: 326411

093032
type: SpeciesReference
stoichiometry: 1.0
species: 326413

093020
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326199
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP):cPP

327307
type: Reaction
kinetic law: 083311
product: 083299
reactant: 083287
fast: false
reversible: true
name: v189 (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P k7 kd7

083299
type: SpeciesReference
stoichiometry: 1.0
species: 326477

083287
type: SpeciesReference
stoichiometry: 1.0
species: 325918

328529
type: Reaction
kinetic law: 111552
product: 111540
reactant: 111528
reactant: 111516
fast: false
reversible: true
name: v807 (ErbB1:ErbB2)#P + ATP -> EGF:ErbB1:ErbB2:ATP k123 kd123

111540
type: SpeciesReference
stoichiometry: 1.0
species: 325992

111528
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111516
type: SpeciesReference
stoichiometry: 1.0
species: 326461

328099
type: Reaction
kinetic law: 101422
product: 101410
reactant: 101398
fast: false
reversible: true
name: v591 (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60

101410
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101398
type: SpeciesReference
stoichiometry: 1.0
species: 326321

328465
type: Reaction
kinetic law: 110024
product: 110012
reactant: 110000
reactant: 109988
fast: false
reversible: true
name: v774 Pase9t + ErbB3/4:ErbB2:Gab1#P## -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k117 kd117

110012
type: SpeciesReference
stoichiometry: 1.0
species: 326895

110000
type: SpeciesReference
stoichiometry: 1.0
species: 326849

326849
type: Species
notes: ErbB3/4:ErbB2:Gab1#P## , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3/4:ErbB2:Gab1_P#

109988
type: SpeciesReference
stoichiometry: 1.0
species: 326885

326605
type: Species
notes: (MEK#P#P:Pase2)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_PP:Pase2)_i

327567
type: Reaction
kinetic law: 089535
product: 089522
reactant: 089508
reactant: 089495
fast: false
reversible: true
name: v320 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089522
type: SpeciesReference
stoichiometry: 1.0
species: 326365

089508
type: SpeciesReference
stoichiometry: 1.0
species: 326359

089495
type: SpeciesReference
stoichiometry: 1.0
species: 326549

327613
type: Reaction
kinetic law: 090676
product: 090664
reactant: 090652
reactant: 090640
fast: false
reversible: true
name: v343 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

090664
type: SpeciesReference
stoichiometry: 1.0
species: 326407

090652
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090640
type: SpeciesReference
stoichiometry: 1.0
species: 326411

328517
type: Reaction
kinetic law: 111264
product: 111252
reactant: 111240
reactant: 111228
fast: false
reversible: true
name: v801 ErbB1_h:ATP + EGF -> EGF:ErbB1:ATP k10b kd10

111252
type: SpeciesReference
stoichiometry: 1.0
species: 325934

111240
type: SpeciesReference
stoichiometry: 1.0
species: 326515

111228
type: SpeciesReference
stoichiometry: 1.0
species: 326923

327003
type: Reaction
kinetic law: 076307
product: 076295
reactant: 076283
reactant: 076271
fast: false
reversible: true
name: v29 ErbB2:ErbB2#P + ATP -> ErbB2:ErbB2#P:ATP k122 kd122

076295
type: SpeciesReference
stoichiometry: 1.0
species: 326000

076283
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076271
type: SpeciesReference
stoichiometry: 1.0
species: 325998

328133
type: Reaction
kinetic law: 102037
product: 102025
reactant: 102013
fast: false
reversible: true
name: v608 (ErbB4:ErbB2) -> R_degraded k62b kd60b

102025
type: SpeciesReference
stoichiometry: 1.0
species: 326641

102013
type: SpeciesReference
stoichiometry: 1.0
species: 326653

327643
type: Reaction
kinetic law: 091396
product: 091384
reactant: 091372
reactant: 091360
fast: false
reversible: true
name: v358 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091384
type: SpeciesReference
stoichiometry: 1.0
species: 326365

091372
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091360
type: SpeciesReference
stoichiometry: 1.0
species: 326359

328227
type: Reaction
kinetic law: 104301
product: 104289
reactant: 104277
reactant: 104264
fast: false
reversible: true
name: v655 RTK_Pase + (ErbB4:ErbB2)#P -> (ErbB2:ErbB4)#P:RTK_Pase k94 kd94

104289
type: SpeciesReference
stoichiometry: 1.0
species: 326767

104277
type: SpeciesReference
stoichiometry: 1.0
species: 326479

104264
type: SpeciesReference
stoichiometry: 1.0
species: 326755

329373
type: Parameter
constant: false
value: 5.92538E-11
name: k120b

327171
type: Reaction
kinetic law: 080356
product: 080344
reactant: 080332
reactant: 080320
fast: false
reversible: true
name: v117 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b

080344
type: SpeciesReference
stoichiometry: 1.0
species: 326251

080332
type: SpeciesReference
stoichiometry: 1.0
species: 326339

080320
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326581
type: Species
notes: (Raf#P:Pase1)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Raf_P:Pase1)_i

325930
type: Species
initial amount: 0.0
notes: 2(EGF:ErbB1:Inh) , plasma membrane
has part: P00533
boundary condition: false
initial concentration: NaN
name: 2(EGF:ErbB1:Inh)
constant: false
has only substance units: true
in compartment: 325898
has version: P01133

327921
type: Reaction
kinetic law: 097910
product: 097898
reactant: 097886
reactant: 097874
fast: false
reversible: true
name: v497 MEK#P#P + Raf#P -> MEK#P:Raf#P k47 kd47

097898
type: SpeciesReference
stoichiometry: 1.0
species: 326597

097886
type: SpeciesReference
stoichiometry: 1.0
species: 326573

097874
type: SpeciesReference
stoichiometry: 1.0
species: 326599

327367
type: Reaction
kinetic law: 084698
product: 084686
reactant: 084674
reactant: 084662
fast: false
reversible: true
name: v220 (ErbB1:ErbB2)#P:GAP + Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24

084686
type: SpeciesReference
stoichiometry: 1.0
species: 326381

084674
type: SpeciesReference
stoichiometry: 1.0
species: 326521

084662
type: SpeciesReference
stoichiometry: 1.0
species: 326495

328381
type: Reaction
kinetic law: 108014
product: 108002
reactant: 107990
reactant: 107978
fast: false
reversible: true
name: v732 (ERK#P#P)_i + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110

108002
type: SpeciesReference
stoichiometry: 1.0
species: 326839

107990
type: SpeciesReference
stoichiometry: 1.0
species: 326695

107978
type: SpeciesReference
stoichiometry: 1.0
species: 326629

327419
type: Reaction
kinetic law: 085954
product: 085942
reactant: 085930
reactant: 085918
fast: false
reversible: true
name: v246 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17

085942
type: SpeciesReference
stoichiometry: 1.0
species: 326347

085930
type: SpeciesReference
stoichiometry: 1.0
species: 326349

085918
type: SpeciesReference
stoichiometry: 1.0
species: 326539

327993
type: Reaction
kinetic law: 099512
product: 099500
reactant: 099488
fast: false
reversible: true
name: v533 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60 kd60

099500
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099488
type: SpeciesReference
stoichiometry: 1.0
species: 326411

328577
type: Reaction
kinetic law: 112747
product: 112735
reactant: 112723
reactant: 112711
fast: false
reversible: true
name: v851 EGF:ErbB1:Inh + EGF:ErbB1_h:ATP -> EGF:ErbB1:Inh::EGF:ErbB1_h:ATP k2 kd2

112735
type: SpeciesReference
stoichiometry: 1.0
species: 326931

326931
type: Species
notes: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)

112723
type: SpeciesReference
stoichiometry: 1.0
species: 326921

112711
type: SpeciesReference
stoichiometry: 1.0
species: 325926

328193
type: Reaction
kinetic law: 103483
product: 103471
reactant: 103459
reactant: 103447
fast: false
reversible: true
name: v638 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k68 kd68b

103471
type: SpeciesReference
stoichiometry: 1.0
species: 326729

103459
type: SpeciesReference
stoichiometry: 1.0
species: 326727

103447
type: SpeciesReference
stoichiometry: 1.0
species: 326707

329293
type: Parameter
constant: true
value: 5.0E-7
name: k102

327295
type: Reaction
kinetic law: 083094
product: 083082
reactant: 083069
fast: false
reversible: true
name: v183 ErbB4:Inh -> ErbB4:Inh k6b kd6b

083082
type: SpeciesReference
stoichiometry: 1.0
species: 326455

083069
type: SpeciesReference
stoichiometry: 1.0
species: 325972

328979
type: Parameter
notes: %internalization rate
constant: true
value: 0.0
name: k5

327725
type: Reaction
kinetic law: 093200
product: 093188
reactant: 093176
reactant: 093164
fast: false
reversible: true
name: v399 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093188
type: SpeciesReference
stoichiometry: 1.0
species: 326108

093176
type: SpeciesReference
stoichiometry: 1.0
species: 326096

093164
type: SpeciesReference
stoichiometry: 1.0
species: 326539

329149
type: Parameter
constant: false
value: 8.33E-7
name: k58

327115
type: Reaction
kinetic law: 079007
product: 078995
reactant: 078983
reactant: 078971
fast: false
reversible: true
name: v89 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4

078995
type: SpeciesReference
stoichiometry: 1.0
species: 326255

078983
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078971
type: SpeciesReference
stoichiometry: 1.0
species: 326253

328245
type: Reaction
kinetic law: 104737
product: 104725
reactant: 104712
reactant: 104700
fast: false
reversible: true
name: v664 ErbB2#P + ErbB2#P -> 2(ErbB2)#P k96 kd96

104725
type: SpeciesReference
stoichiometry: 1.0
species: 326473

104712
type: SpeciesReference
stoichiometry: 1.0
species: 326771

104700
type: SpeciesReference
stoichiometry: 1.0
species: 326771

326034
type: Species
notes: (HRG:ErbB4:ErbB1) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB4:ErbB1)

327385
type: Reaction
kinetic law: 085133
product: 085121
reactant: 085109
reactant: 085097
fast: false
reversible: true
name: v229 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

085121
type: SpeciesReference
stoichiometry: 1.0
species: 326213

085109
type: SpeciesReference
stoichiometry: 1.0
species: 326489

085097
type: SpeciesReference
stoichiometry: 1.0
species: 326521

327479
type: Reaction
kinetic law: 087398
product: 087385
reactant: 087373
reactant: 087361
fast: false
reversible: true
name: v276 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

087385
type: SpeciesReference
stoichiometry: 1.0
species: 326333

087373
type: SpeciesReference
stoichiometry: 1.0
species: 326337

087361
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329023
type: Parameter
constant: true
value: 1.67E-5
name: k17

327845
type: Reaction
kinetic law: 096078
product: 096066
reactant: 096054
reactant: 096042
fast: false
reversible: true
name: v459 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37

096066
type: SpeciesReference
stoichiometry: 1.0
species: 326401

096054
type: SpeciesReference
stoichiometry: 1.0
species: 326525

096042
type: SpeciesReference
stoichiometry: 1.0
species: 326499

327619
type: Reaction
kinetic law: 090820
product: 090808
reactant: 090796
reactant: 090784
fast: false
reversible: true
name: v346 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

090808
type: SpeciesReference
stoichiometry: 1.0
species: 326068

090796
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090784
type: SpeciesReference
stoichiometry: 1.0
species: 326060

325964
type: Species
has version: P01133
in compartment: 325898
constant: false
initial concentration: NaN
name: EGF:ErbB1:Inh:ErB3
notes: EGF:ErbB1:Inh:ErB3 , plasma membrane
boundary condition: false
has part: P00533
has only substance units: true
initial amount: 0.0

326485
type: Species
notes: 2(ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Shc

328595
type: Reaction
kinetic law: 113180
product: 113168
reactant: 113156
reactant: 113144
fast: false
reversible: true
name: v860 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k123h kd123h

113168
type: SpeciesReference
stoichiometry: 1.0
species: 326941

326941
type: Species
notes: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive

113156
type: SpeciesReference
stoichiometry: 1.0
species: 325980

113144
type: SpeciesReference
stoichiometry: 1.0
species: 326425

326891
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:Pase9t

328043
type: Reaction
kinetic law: 100412
product: 100400
reactant: 100388
fast: false
reversible: true
name: v559 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100400
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100388
type: SpeciesReference
stoichiometry: 1.0
species: 326367

329167
type: Parameter
constant: true
value: 1.67E-5
name: k64

327773
type: Reaction
kinetic law: 094357
product: 094345
reactant: 094333
reactant: 094321
fast: false
reversible: true
name: v423 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094345
type: SpeciesReference
stoichiometry: 1.0
species: 326277

094333
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094321
type: SpeciesReference
stoichiometry: 1.0
species: 326507

327279
type: Reaction
kinetic law: 082804
product: 082792
reactant: 082780
fast: false
reversible: true
name: v175 2(EGF:ErbB1)#P:GAP:Grb2 + -> 2(EGF:ErbB1)#P:GAP:Grb2 k6 kd6

082792
type: SpeciesReference
stoichiometry: 1.0
species: 326419

082780
type: SpeciesReference
stoichiometry: 1.0
species: 326054

328357
type: Reaction
kinetic law: 107435
product: 107423
reactant: 107411
reactant: 107399
fast: false
reversible: true
name: v720 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k108 kd108

107423
type: SpeciesReference
stoichiometry: 1.0
species: 326819

107411
type: SpeciesReference
stoichiometry: 1.0
species: 326026

107399
type: SpeciesReference
stoichiometry: 1.0
species: 326805

327511
type: Reaction
kinetic law: 088166
product: 088154
reactant: 088142
reactant: 088130
fast: false
reversible: true
name: v292 (Ras:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088154
type: SpeciesReference
stoichiometry: 1.0
species: 326417

088142
type: SpeciesReference
stoichiometry: 1.0
species: 326421

088130
type: SpeciesReference
stoichiometry: 1.0
species: 326545

328089
type: Reaction
kinetic law: 101241
product: 101229
reactant: 101217
fast: false
reversible: true
name: v586 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60

101229
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101217
type: SpeciesReference
stoichiometry: 1.0
species: 326325

328293
type: Reaction
kinetic law: 105895
product: 105883
reactant: 105871
reactant: 105859
fast: false
reversible: true
name: v688 2(EGF:ErbB1)#P:GAP:Grb2 + Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 k105 kd105

105883
type: SpeciesReference
stoichiometry: 1.0
species: 326026

105871
type: SpeciesReference
stoichiometry: 1.0
species: 326801

105859
type: SpeciesReference
stoichiometry: 1.0
species: 326054

328031
type: Reaction
kinetic law: 100196
product: 100184
reactant: 100172
fast: false
reversible: true
name: v553 (ErbB1:ErbB3)#P:GAP:Grb2 -> R_degraded k60b kd60

100184
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100172
type: SpeciesReference
stoichiometry: 1.0
species: 326379

328989
type: Parameter
notes: %Bart2003
constant: false
value: 0.013
name: k6

328931
type: Parameter
constant: false
units: item
value: NaN

329041
type: Parameter
constant: true
value: 0.23
name: kd21

326879
type: Species
notes: AKT:P:P:Raf:P:Ser_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P:Raf:P:Ser_i

328157
type: Reaction
kinetic law: 102615
product: 102603
reactant: 102591
reactant: 102579
fast: false
reversible: true
name: v620 (ERK#P#P)_i + Sos#P -> ((ERK#P#P):Sos)_i k65 kd65

102603
type: SpeciesReference
stoichiometry: 1.0
species: 326665

326665
type: Species
notes: ((ERK#P#P):Sos)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ((ERK_PP):Sos)_i

102591
type: SpeciesReference
stoichiometry: 1.0
species: 326671

102579
type: SpeciesReference
stoichiometry: 1.0
species: 326629

327667
type: Reaction
kinetic law: 091974
product: 091962
reactant: 091950
reactant: 091938
fast: false
reversible: true
name: v370 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b

091962
type: SpeciesReference
stoichiometry: 1.0
species: 326555

091950
type: SpeciesReference
stoichiometry: 1.0
species: 326503

091938
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327957
type: Reaction
kinetic law: 098777
product: 098765
reactant: 098753
reactant: 098741
fast: false
reversible: true
name: v515 ERK#P#P + Pase3 -> ERK#P#P:Pase3 k56 kd56

098765
type: SpeciesReference
stoichiometry: 1.0
species: 326633

326633
type: Species
notes: ERK#P#P:Pase3 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_PP:Pase3

098753
type: SpeciesReference
stoichiometry: 1.0
species: 326631

098741
type: SpeciesReference
stoichiometry: 1.0
species: 326627

329397
type: Parameter
constant: true
value: 0.0
name: k123h

327893
type: Reaction
kinetic law: 097235
product: 097223
reactant: 097211
reactant: 097199
fast: false
reversible: true
name: v483 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097223
type: SpeciesReference
stoichiometry: 1.0
species: 326277

097211
type: SpeciesReference
stoichiometry: 1.0
species: 326449

097199
type: SpeciesReference
stoichiometry: 1.0
species: 326577

327251
type: Reaction
kinetic law: 082286
product: 082274
reactant: 082262
reactant: 082250
fast: false
reversible: true
name: v161 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k5 kd5

082274
type: SpeciesReference
stoichiometry: 1.0
species: 326058

082262
type: SpeciesReference
stoichiometry: 1.0
species: 326309

082250
type: SpeciesReference
stoichiometry: 1.0
species: 326419

328061
type: Reaction
kinetic law: 100736
product: 100724
reactant: 100713
fast: false
reversible: true
name: v570 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60

100724
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100713
type: SpeciesReference
stoichiometry: 1.0
species: 326357

327195
type: Reaction
kinetic law: 080933
product: 080921
reactant: 080909
reactant: 080896
fast: false
reversible: true
name: v130 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b

080921
type: SpeciesReference
stoichiometry: 1.0
species: 326203

080909
type: SpeciesReference
stoichiometry: 1.0
species: 326363

080896
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328201
type: Reaction
kinetic law: 103676
product: 103664
reactant: 103652
reactant: 103640
fast: false
reversible: true
name: v642 PDK1 + PIP3:AKT -> PIP3:AKT:PDK1 k70 kd70

103664
type: SpeciesReference
stoichiometry: 1.0
species: 326743

103652
type: SpeciesReference
stoichiometry: 1.0
species: 326733

326733
type: Species
notes: PIP3:AKT , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT

103640
type: SpeciesReference
stoichiometry: 1.0
species: 326739

327711
type: Reaction
kinetic law: 092889
product: 092877
reactant: 092865
fast: false
reversible: true
name: v392 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23

092877
type: SpeciesReference
stoichiometry: 1.0
species: 326533

092865
type: SpeciesReference
stoichiometry: 1.0
species: 326559

329131
type: Parameter
constant: true
value: 0.033
name: kd52

328461
type: Reaction
kinetic law: 109928
product: 109916
reactant: 109903
reactant: 109891
fast: false
reversible: true
name: v772 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117

109916
type: SpeciesReference
stoichiometry: 1.0
species: 326891

109903
type: SpeciesReference
stoichiometry: 1.0
species: 326855

109891
type: SpeciesReference
stoichiometry: 1.0
species: 326885

327809
type: Reaction
kinetic law: 095225
product: 095213
reactant: 095201
reactant: 095189
fast: false
reversible: true
name: v441 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34

095213
type: SpeciesReference
stoichiometry: 1.0
species: 326319

095201
type: SpeciesReference
stoichiometry: 1.0
species: 326577

095189
type: SpeciesReference
stoichiometry: 1.0
species: 326513

327371
type: Reaction
kinetic law: 084794
product: 084782
reactant: 084770
reactant: 084758
fast: false
reversible: true
name: v222 (ErbB1:ErbB4)#P:GAP + Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24

084782
type: SpeciesReference
stoichiometry: 1.0
species: 326377

084770
type: SpeciesReference
stoichiometry: 1.0
species: 326521

084758
type: SpeciesReference
stoichiometry: 1.0
species: 326499

327749
type: Reaction
kinetic law: 093778
product: 093766
reactant: 093754
reactant: 093742
fast: false
reversible: true
name: v411 (Ras_activated:GTP)_i + (Raf#P)_i -> (Raf:Ras:GTP)_i k29 kd29

093766
type: SpeciesReference
stoichiometry: 1.0
species: 326569

093754
type: SpeciesReference
stoichiometry: 1.0
species: 326571

093742
type: SpeciesReference
stoichiometry: 1.0
species: 326549

328269
type: Reaction
kinetic law: 105315
product: 105303
reactant: 105291
reactant: 105279
fast: false
reversible: true
name: v676 EGF:ErbB1#P + ErbB4#P -> (ErbB1:ErbB4)#P k102 kd102

105303
type: SpeciesReference
stoichiometry: 1.0
species: 326469

105291
type: SpeciesReference
stoichiometry: 1.0
species: 326781

326781
type: Species
notes: ErbB4#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4_P

105279
type: SpeciesReference
stoichiometry: 1.0
species: 326777

327139
type: Reaction
kinetic law: 079588
product: 079576
reactant: 079564
reactant: 079552
fast: false
reversible: true
name: v101 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4

079576
type: SpeciesReference
stoichiometry: 1.0
species: 326303

079564
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079552
type: SpeciesReference
stoichiometry: 1.0
species: 326301

327423
type: Reaction
kinetic law: 086051
product: 086039
reactant: 086027
reactant: 086014
fast: false
reversible: true
name: v248 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17

086039
type: SpeciesReference
stoichiometry: 1.0
species: 326060

086027
type: SpeciesReference
stoichiometry: 1.0
species: 326054

086014
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328941
type: Parameter
constant: false
value: 0.0
name: total ERK_PP

328007
type: Reaction
kinetic law: 099764
product: 099752
reactant: 099740
fast: false
reversible: true
name: v541 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60

099752
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099740
type: SpeciesReference
stoichiometry: 1.0
species: 326403

328581
type: Reaction
kinetic law: 112843
product: 112831
reactant: 112819
reactant: 112807
fast: false
reversible: true
name: v853 EGF:ErbB1_h:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh k2 kd2

328880
type: LocalParameter
value: 1.0
name: kd

112831
type: SpeciesReference
stoichiometry: 1.0
species: 326935

326935
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)

112819
type: SpeciesReference
stoichiometry: 1.0
species: 326913

112807
type: SpeciesReference
stoichiometry: 1.0
species: 326921

329051
type: Parameter
constant: true
value: 0.55
name: kd24

329377
type: Parameter
constant: true
value: 0.001
name: Ks

328313
type: Reaction
kinetic law: 106377
product: 106364
reactant: 106352
reactant: 106340
fast: false
reversible: true
name: v698 PIP2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b

106364
type: SpeciesReference
stoichiometry: 1.0
species: 326719

106352
type: SpeciesReference
stoichiometry: 1.0
species: 326685

106340
type: SpeciesReference
stoichiometry: 1.0
species: 326793

329153
type: Parameter
constant: true
value: 8.85125E-6
name: k52

327673
type: Reaction
kinetic law: 092118
product: 092106
reactant: 092094
reactant: 092082
fast: false
reversible: true
name: v373 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b

092106
type: SpeciesReference
stoichiometry: 1.0
species: 326561

092094
type: SpeciesReference
stoichiometry: 1.0
species: 326497

092082
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327063
type: Reaction
kinetic law: 077756
product: 077744
reactant: 077731
reactant: 077719
fast: false
reversible: true
name: v60 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4

077744
type: SpeciesReference
stoichiometry: 1.0
species: 326122

077731
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077719
type: SpeciesReference
stoichiometry: 1.0
species: 326120

327869
type: Reaction
kinetic law: 096656
product: 096644
reactant: 096632
reactant: 096620
fast: false
reversible: true
name: v471 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

096644
type: SpeciesReference
stoichiometry: 1.0
species: 326339

096632
type: SpeciesReference
stoichiometry: 1.0
species: 326525

096620
type: SpeciesReference
stoichiometry: 1.0
species: 326513

327223
type: Reaction
kinetic law: 081610
product: 081598
reactant: 081586
reactant: 081574
fast: false
reversible: true
name: v146 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b

081598
type: SpeciesReference
stoichiometry: 1.0
species: 326118

081586
type: SpeciesReference
stoichiometry: 1.0
species: 326391

081574
type: SpeciesReference
stoichiometry: 1.0
species: 326309

326963
type: Reaction
kinetic law: 075313
product: 075301
reactant: 075289
reactant: 075277
fast: false
reversible: true
name: v9 EGF:ErbB1:ATP + ErbB2 -> EGF:ErbB1:ErbB2 k2b kd2b

075301
type: SpeciesReference
stoichiometry: 1.0
species: 325940

075289
type: SpeciesReference
stoichiometry: 1.0
species: 325938

075277
type: SpeciesReference
stoichiometry: 1.0
species: 325914

327483
type: Reaction
kinetic law: 087494
product: 087482
reactant: 087470
reactant: 087458
fast: false
reversible: true
name: v278 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

087482
type: SpeciesReference
stoichiometry: 1.0
species: 326335

087470
type: SpeciesReference
stoichiometry: 1.0
species: 326325

087458
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329213
type: Parameter
notes: % determines sharpness of AKT peak
constant: false
value: 0.00633957
name: kd75

327623
type: Reaction
kinetic law: 090916
product: 090904
reactant: 090892
reactant: 090880
fast: false
reversible: true
name: v348 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

090904
type: SpeciesReference
stoichiometry: 1.0
species: 326128

326128
type: Species
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

090892
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090880
type: SpeciesReference
stoichiometry: 1.0
species: 326104

329353
type: Parameter
constant: false
value: 0.0150356
name: k116

327797
type: Reaction
kinetic law: 094935
product: 094923
reactant: 094911
reactant: 094899
fast: false
reversible: true
name: v435 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34

094923
type: SpeciesReference
stoichiometry: 1.0
species: 326359

094911
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094899
type: SpeciesReference
stoichiometry: 1.0
species: 326499

328433
type: Reaction
kinetic law: 109267
product: 109255
reactant: 109243
reactant: 109231
fast: false
reversible: true
name: v758 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k113 kd113

109255
type: SpeciesReference
stoichiometry: 1.0
species: 326863

326863
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):PI3K:Ras:GDP

109243
type: SpeciesReference
stoichiometry: 1.0
species: 326681

326681
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1_P:PI3K

109231
type: SpeciesReference
stoichiometry: 1.0
species: 326543

327535
type: Reaction
kinetic law: 088747
product: 088735
reactant: 088723
reactant: 088711
fast: false
reversible: true
name: v304 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088735
type: SpeciesReference
stoichiometry: 1.0
species: 326375

088723
type: SpeciesReference
stoichiometry: 1.0
species: 326545

088711
type: SpeciesReference
stoichiometry: 1.0
species: 326363

327151
type: Reaction
kinetic law: 079876
product: 079864
reactant: 079852
reactant: 079840
fast: false
reversible: true
name: v107 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b

079864
type: SpeciesReference
stoichiometry: 1.0
species: 326291

326291
type: Species
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:cPP

079852
type: SpeciesReference
stoichiometry: 1.0
species: 326319

079840
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327901
type: Reaction
kinetic law: 097429
product: 097417
reactant: 097405
reactant: 097393
fast: false
reversible: true
name: v487 Pase1 + (Raf#P)_i -> (Raf#P:Pase1)_i k42 kd42

097417
type: SpeciesReference
stoichiometry: 1.0
species: 326581

097405
type: SpeciesReference
stoichiometry: 1.0
species: 326571

097393
type: SpeciesReference
stoichiometry: 1.0
species: 326579

328101
type: Reaction
kinetic law: 101458
product: 101446
reactant: 101434
fast: false
reversible: true
name: v592 (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60

101446
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101434
type: SpeciesReference
stoichiometry: 1.0
species: 326319

327081
type: Reaction
kinetic law: 078190
product: 078178
reactant: 078166
reactant: 078154
fast: false
reversible: true
name: v69 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4

078178
type: SpeciesReference
stoichiometry: 1.0
species: 326158

078166
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078154
type: SpeciesReference
stoichiometry: 1.0
species: 326156

328361
type: Reaction
kinetic law: 107532
product: 107520
reactant: 107508
reactant: 107496
fast: false
reversible: true
name: v722 PIP3 + Shp -> PIP3:Shp k109 kd109

107520
type: SpeciesReference
stoichiometry: 1.0
species: 326795

326795
type: Species
name: PIP3:Shp
boundary condition: false
has part: CHEBI:16618
constant: false
has only substance units: true
initial amount: 0.0
in compartment: 325908
notes: PIP3:Shp , cytoplasm
initial concentration: NaN

107508
type: SpeciesReference
stoichiometry: 1.0
species: 326791

326791
type: Species
notes: Shp , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 2213.59
in compartment: 325908
name: Shp

107496
type: SpeciesReference
stoichiometry: 1.0
species: 326707

329387
type: Parameter
constant: true
value: 0.177828
name: kd123

325922
type: Species
boundary condition: false
notes: (ErbB4:ErbB2)#P , plasma membrane
has only substance units: true
initial amount: 0.0
initial concentration: NaN
has part: P04626
in compartment: 325898
has part: Q15303
constant: false
name: (ErbB4:ErbB2)_P

329027
type: Parameter
constant: true
value: 2.5E-5
name: k18

327335
type: Reaction
kinetic law: 083937
product: 083925
reactant: 083913
reactant: 083901
fast: false
reversible: true
name: v203 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8

083925
type: SpeciesReference
stoichiometry: 1.0
species: 326509

083913
type: SpeciesReference
stoichiometry: 1.0
species: 325922

083901
type: SpeciesReference
stoichiometry: 1.0
species: 326493

327705
type: Reaction
kinetic law: 092781
product: 092769
reactant: 092757
fast: false
reversible: true
name: v389 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23

092769
type: SpeciesReference
stoichiometry: 1.0
species: 326527

092757
type: SpeciesReference
stoichiometry: 1.0
species: 326553

328085
type: Reaction
kinetic law: 101169
product: 101157
reactant: 101145
fast: false
reversible: true
name: v584 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60

101157
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101145
type: SpeciesReference
stoichiometry: 1.0
species: 326337

327649
type: Reaction
kinetic law: 091540
product: 091528
reactant: 091516
reactant: 091504
fast: false
reversible: true
name: v361 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

091528
type: SpeciesReference
stoichiometry: 1.0
species: 326269

091516
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091504
type: SpeciesReference
stoichiometry: 1.0
species: 326253

327039
type: Reaction
kinetic law: 077177
product: 077165
reactant: 077153
reactant: 077140
fast: false
reversible: true
name: v47 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k4 kd4

077165
type: SpeciesReference
stoichiometry: 1.0
species: 326074

077153
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077140
type: SpeciesReference
stoichiometry: 1.0
species: 326072

329261
type: Parameter
constant: false
value: 1000000.0
name: k97

327961
type: Reaction
kinetic law: 098873
product: 098861
reactant: 098849
reactant: 098837
fast: false
reversible: true
name: v517 (ERK#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k57 kd57

098861
type: SpeciesReference
stoichiometry: 1.0
species: 326635

098849
type: SpeciesReference
stoichiometry: 1.0
species: 326631

098837
type: SpeciesReference
stoichiometry: 1.0
species: 326623

325974
type: Species
name: (EGF:ErbB1:ErbB3)_P:Inh
has version: P01133
notes: (EGF:ErbB1:ErbB3)#P:Inh , plasma membrane
boundary condition: false
constant: false
has only substance units: true
initial concentration: NaN
in compartment: 325898
has part: P00533
initial amount: 0.0

327323
type: Reaction
kinetic law: 083648
product: 083636
reactant: 083624
reactant: 083612
fast: false
reversible: true
name: v197 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8

083636
type: SpeciesReference
stoichiometry: 1.0
species: 326431

083624
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083612
type: SpeciesReference
stoichiometry: 1.0
species: 326427

328545
type: Reaction
kinetic law: 111936
product: 111924
reactant: 111912
reactant: 111900
fast: false
reversible: true
name: v815 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123

111924
type: SpeciesReference
stoichiometry: 1.0
species: 326004

326004
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1:ATP

111912
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111900
type: SpeciesReference
stoichiometry: 1.0
species: 326687

329117
type: Parameter
constant: true
value: 0.0
name: k47

329363
type: Parameter
constant: true
value: 0.03
name: kd118

327395
type: Reaction
kinetic law: 085374
product: 085362
reactant: 085350
reactant: 085338
fast: false
reversible: true
name: v234 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

085362
type: SpeciesReference
stoichiometry: 1.0
species: 326341

085350
type: SpeciesReference
stoichiometry: 1.0
species: 326451

085338
type: SpeciesReference
stoichiometry: 1.0
species: 326521

327129
type: Reaction
kinetic law: 079345
product: 079333
reactant: 079321
reactant: 079309
fast: false
reversible: true
name: v96 (ErbB4:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k4b kd4

079333
type: SpeciesReference
stoichiometry: 1.0
species: 326283

079321
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079309
type: SpeciesReference
stoichiometry: 1.0
species: 326281

328409
type: Reaction
kinetic law: 108688
product: 108676
reactant: 108664
reactant: 108652
fast: false
reversible: true
name: v746 (ERK#P#P)_i + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111

108676
type: SpeciesReference
stoichiometry: 1.0
species: 326827

108664
type: SpeciesReference
stoichiometry: 1.0
species: 326857

108652
type: SpeciesReference
stoichiometry: 1.0
species: 326629

329321
type: Parameter
constant: true
value: 0.0
name: k108

326259
type: Species
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP

327999
type: Reaction
kinetic law: 099620
product: 099608
reactant: 099596
fast: false
reversible: true
name: v537 ErbB3 -> R_degraded k60b kd60b

099608
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099596
type: SpeciesReference
stoichiometry: 1.0
species: 325954

327447
type: Reaction
kinetic law: 086628
product: 086616
reactant: 086604
reactant: 086592
fast: false
reversible: true
name: v260 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086616
type: SpeciesReference
stoichiometry: 1.0
species: 326116

086604
type: SpeciesReference
stoichiometry: 1.0
species: 326104

086592
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328199
type: Reaction
kinetic law: 103628
product: 103616
reactant: 103604
reactant: 103592
fast: false
reversible: true
name: v641 PDK1 + PIP3:AKT#P -> PIP3:AKT#P:PDK1 k70 kd70

103616
type: SpeciesReference
stoichiometry: 1.0
species: 326741

103604
type: SpeciesReference
stoichiometry: 1.0
species: 326737

103592
type: SpeciesReference
stoichiometry: 1.0
species: 326739

327353
type: Reaction
kinetic law: 084361
product: 084349
reactant: 084337
reactant: 084325
fast: false
reversible: true
name: v213 Grb2 + (Shc#P) -> (Shc#P):Grb2 k16 kd24

084349
type: SpeciesReference
stoichiometry: 1.0
species: 326525

084337
type: SpeciesReference
stoichiometry: 1.0
species: 326523

084325
type: SpeciesReference
stoichiometry: 1.0
species: 326521

329181
type: Parameter
constant: true
value: 0.02
name: kd67

329317
type: Parameter
constant: true
value: 3.33E-5
name: k107

327813
type: Reaction
kinetic law: 095309
product: 095297
reactant: 095285
fast: false
reversible: true
name: v443 (Shc#P) + -> Shc k36 kd36

095297
type: SpeciesReference
stoichiometry: 1.0
species: 326551

095285
type: SpeciesReference
stoichiometry: 1.0
species: 326523

329037
type: Parameter
constant: true
value: 0.4
name: kd20

325982
type: Species
constant: false
in compartment: 325908
has only substance units: true
has part: P00533
boundary condition: false
has version: P01133
notes: (EGF:ErbB1:ErbB2):ATP , cytoplasm
name: (EGF:ErbB1:ErbB2):ATP
initial concentration: NaN
initial amount: 0.0

327753
type: Reaction
kinetic law: 093875
product: 093863
reactant: 093851
reactant: 093839
fast: false
reversible: true
name: v413 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

093863
type: SpeciesReference
stoichiometry: 1.0
species: 326076

093851
type: SpeciesReference
stoichiometry: 1.0
species: 326575

093839
type: SpeciesReference
stoichiometry: 1.0
species: 326429

328563
type: Reaction
kinetic law: 112403
product: 112391
reactant: 112379
reactant: 112366
fast: false
reversible: true
name: v824 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2:ATP k123 kd123

112391
type: SpeciesReference
stoichiometry: 1.0
species: 326040

112379
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112366
type: SpeciesReference
stoichiometry: 1.0
species: 325922

328337
type: Reaction
kinetic law: 106954
product: 106942
reactant: 106930
reactant: 106918
fast: false
reversible: true
name: v710 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107

106942
type: SpeciesReference
stoichiometry: 1.0
species: 326813

106930
type: SpeciesReference
stoichiometry: 1.0
species: 326695

106918
type: SpeciesReference
stoichiometry: 1.0
species: 326805

328011
type: Reaction
kinetic law: 099836
product: 099824
reactant: 099812
fast: false
reversible: true
name: v543 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60

099824
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099812
type: SpeciesReference
stoichiometry: 1.0
species: 326399

329177
type: Parameter
constant: true
value: 0.2
name: kd66

327697
type: Reaction
kinetic law: 092637
product: 092625
reactant: 092613
fast: false
reversible: true
name: v385 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23

092625
type: SpeciesReference
stoichiometry: 1.0
species: 326489

092613
type: SpeciesReference
stoichiometry: 1.0
species: 326485

327217
type: Reaction
kinetic law: 081463
product: 081451
reactant: 081439
reactant: 081427
fast: false
reversible: true
name: v143 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b

081451
type: SpeciesReference
stoichiometry: 1.0
species: 326130

081439
type: SpeciesReference
stoichiometry: 1.0
species: 326385

081427
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327087
type: Reaction
kinetic law: 078334
product: 078322
reactant: 078310
reactant: 078298
fast: false
reversible: true
name: v72 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4

078322
type: SpeciesReference
stoichiometry: 1.0
species: 326199

078310
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078298
type: SpeciesReference
stoichiometry: 1.0
species: 326197

329135
type: Parameter
constant: true
value: 0.0
name: k53

327801
type: Reaction
kinetic law: 095033
product: 095021
reactant: 095009
reactant: 094997
fast: false
reversible: true
name: v437 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34

095021
type: SpeciesReference
stoichiometry: 1.0
species: 326347

095009
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094997
type: SpeciesReference
stoichiometry: 1.0
species: 326483

326953
type: Reaction
kinetic law: 075073
product: 075061
reactant: 075049
reactant: 075036
fast: false
reversible: true
name: v4 EGF + ErbB1:Inh -> EGF:ErbB1:Inh k1 kd1

075061
type: SpeciesReference
stoichiometry: 1.0
species: 325926

075049
type: SpeciesReference
stoichiometry: 1.0
species: 325924

325924
type: Species
name: ErbB1:Inh
constant: false
boundary condition: false
in compartment: 325898
initial amount: 0.0
initial concentration: NaN
has only substance units: true
notes: ErbB1:Inh , plasma membrane
has part: P00533

075036
type: SpeciesReference
stoichiometry: 1.0
species: 325910

327473
type: Reaction
kinetic law: 087253
product: 087241
reactant: 087229
reactant: 087217
fast: false
reversible: true
name: v273 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087241
type: SpeciesReference
stoichiometry: 1.0
species: 326237

087229
type: SpeciesReference
stoichiometry: 1.0
species: 326233

087217
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327247
type: Reaction
kinetic law: 082189
product: 082177
reactant: 082165
reactant: 082153
fast: false
reversible: true
name: v159 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5

082177
type: SpeciesReference
stoichiometry: 1.0
species: 326070

082165
type: SpeciesReference
stoichiometry: 1.0
species: 326415

082153
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328057
type: Reaction
kinetic law: 100665
product: 100653
reactant: 100641
fast: false
reversible: true
name: v568 2(ErbB2)#P:GAP:Shc -> R_degraded k60b kd60

100653
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100641
type: SpeciesReference
stoichiometry: 1.0
species: 326487

328427
type: Reaction
kinetic law: 109122
product: 109110
reactant: 109098
reactant: 109086
fast: false
reversible: true
name: v755 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112

109110
type: SpeciesReference
stoichiometry: 1.0
species: 326871

109098
type: SpeciesReference
stoichiometry: 1.0
species: 326697

109086
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329343
type: Parameter
constant: true
value: 177.828
name: kd113

328261
type: Reaction
kinetic law: 105122
product: 105109
reactant: 105097
reactant: 105085
fast: false
reversible: true
name: v672 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101

105109
type: SpeciesReference
stoichiometry: 1.0
species: 326675

105097
type: SpeciesReference
stoichiometry: 1.0
species: 326413

105085
type: SpeciesReference
stoichiometry: 1.0
species: 326671

327525
type: Reaction
kinetic law: 088504
product: 088492
reactant: 088480
reactant: 088468
fast: false
reversible: true
name: v299 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088492
type: SpeciesReference
stoichiometry: 1.0
species: 326391

088480
type: SpeciesReference
stoichiometry: 1.0
species: 326545

088468
type: SpeciesReference
stoichiometry: 1.0
species: 326397

329237
type: Parameter
constant: true
value: 0.0
name: k95

327873
type: Reaction
kinetic law: 096752
product: 096740
reactant: 096728
reactant: 096716
fast: false
reversible: true
name: v473 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

096740
type: SpeciesReference
stoichiometry: 1.0
species: 326076

096728
type: SpeciesReference
stoichiometry: 1.0
species: 326437

096716
type: SpeciesReference
stoichiometry: 1.0
species: 326577

328457
type: Reaction
kinetic law: 109831
product: 109819
reactant: 109807
reactant: 109795
fast: false
reversible: true
name: v770 Pase9t + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1):Gab1#P##:Pase9t k117 kd117

109819
type: SpeciesReference
stoichiometry: 1.0
species: 326887

109807
type: SpeciesReference
stoichiometry: 1.0
species: 326859

109795
type: SpeciesReference
stoichiometry: 1.0
species: 326885

327175
type: Reaction
kinetic law: 080452
product: 080440
reactant: 080428
reactant: 080416
fast: false
reversible: true
name: v120 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b

080440
type: SpeciesReference
stoichiometry: 1.0
species: 326243

080428
type: SpeciesReference
stoichiometry: 1.0
species: 326343

080416
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327925
type: Reaction
kinetic law: 098007
product: 097995
reactant: 097983
reactant: 097971
fast: false
reversible: true
name: v499 (MEK#P#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k48 kd48

097995
type: SpeciesReference
stoichiometry: 1.0
species: 326605

097983
type: SpeciesReference
stoichiometry: 1.0
species: 326603

097971
type: SpeciesReference
stoichiometry: 1.0
species: 326601

328945
type: Parameter
constant: false
value: 0.0
name: total AKT_PP

329339
type: Parameter
constant: true
value: 0.1
name: kd112

327605
type: Reaction
kinetic law: 090480
product: 090468
reactant: 090456
reactant: 090444
fast: false
reversible: true
name: v339 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

090468
type: SpeciesReference
stoichiometry: 1.0
species: 326241

090456
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090444
type: SpeciesReference
stoichiometry: 1.0
species: 326233

328509
type: Reaction
kinetic law: 111084
product: 111072
reactant: 111060
reactant: 111048
fast: false
reversible: true
name: v796 EGF:ErbB1:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1:ErbB1_h:Inh k2 kd2

111072
type: SpeciesReference
stoichiometry: 1.0
species: 326915

326915
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)

111060
type: SpeciesReference
stoichiometry: 1.0
species: 326913

111048
type: SpeciesReference
stoichiometry: 1.0
species: 325914

328125
type: Reaction
kinetic law: 101893
product: 101881
reactant: 101869
fast: false
reversible: true
name: v604 (HRG:ErbB4:ErbB1) -> R_degraded k62b kd60b

101881
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101869
type: SpeciesReference
stoichiometry: 1.0
species: 326649

328385
type: Reaction
kinetic law: 108110
product: 108098
reactant: 108086
reactant: 108074
fast: false
reversible: true
name: v734 (ERK#P#P)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110

108098
type: SpeciesReference
stoichiometry: 1.0
species: 326843

326843
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i

108086
type: SpeciesReference
stoichiometry: 1.0
species: 326699

108074
type: SpeciesReference
stoichiometry: 1.0
species: 326629

327329
type: Reaction
kinetic law: 083793
product: 083781
reactant: 083769
reactant: 083757
fast: false
reversible: true
name: v200 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b

083781
type: SpeciesReference
stoichiometry: 1.0
species: 326503

083769
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083757
type: SpeciesReference
stoichiometry: 1.0
species: 326465

329081
type: Parameter
constant: false
value: 0.0015
name: kd35

327265
type: Reaction
kinetic law: 082551
product: 082539
reactant: 082527
fast: false
reversible: true
name: v168 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k6 kd6

082539
type: SpeciesReference
stoichiometry: 1.0
species: 326439

082527
type: SpeciesReference
stoichiometry: 1.0
species: 326437

326873
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP

327359
type: Reaction
kinetic law: 084505
product: 084493
reactant: 084481
reactant: 084469
fast: false
reversible: true
name: v216 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24

084493
type: SpeciesReference
stoichiometry: 1.0
species: 326413

084481
type: SpeciesReference
stoichiometry: 1.0
species: 326439

084469
type: SpeciesReference
stoichiometry: 1.0
species: 326521

327729
type: Reaction
kinetic law: 093296
product: 093284
reactant: 093272
reactant: 093260
fast: false
reversible: true
name: v401 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093284
type: SpeciesReference
stoichiometry: 1.0
species: 326397

093272
type: SpeciesReference
stoichiometry: 1.0
species: 326403

093260
type: SpeciesReference
stoichiometry: 1.0
species: 326539

327317
type: Reaction
kinetic law: 083504
product: 083492
reactant: 083480
reactant: 083468
fast: false
reversible: true
name: v194 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8b kd8b

083492
type: SpeciesReference
stoichiometry: 1.0
species: 326495

083480
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083468
type: SpeciesReference
stoichiometry: 1.0
species: 326463

328539
type: Reaction
kinetic law: 111792
product: 111780
reactant: 111768
reactant: 111756
fast: false
reversible: true
name: v812 (ErbB1:ErbB3)#P + ATP -> EGF:ErbB1:ErbB3:ATP k123 kd123

111780
type: SpeciesReference
stoichiometry: 1.0
species: 325994

111768
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111756
type: SpeciesReference
stoichiometry: 1.0
species: 326465

327899
type: Reaction
kinetic law: 097381
product: 097369
reactant: 097357
reactant: 097345
fast: false
reversible: true
name: v486 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097369
type: SpeciesReference
stoichiometry: 1.0
species: 326337

097357
type: SpeciesReference
stoichiometry: 1.0
species: 326459

097345
type: SpeciesReference
stoichiometry: 1.0
species: 326577

329145
type: Parameter
constant: true
value: 0.0076
name: kd57

328475
type: Reaction
kinetic law: 110267
product: 110255
reactant: 110243
reactant: 110231
fast: false
reversible: true
name: v779 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118

110255
type: SpeciesReference
stoichiometry: 1.0
species: 326891

110243
type: SpeciesReference
stoichiometry: 1.0
species: 326691

110231
type: SpeciesReference
stoichiometry: 1.0
species: 326885

327985
type: Reaction
kinetic law: 099368
product: 099356
reactant: 099344
fast: false
reversible: true
name: v529 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60 kd60

099356
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099344
type: SpeciesReference
stoichiometry: 1.0
species: 326415

327573
type: Reaction
kinetic law: 089691
product: 089678
reactant: 089665
reactant: 089652
fast: false
reversible: true
name: v323 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089678
type: SpeciesReference
stoichiometry: 1.0
species: 326415

089665
type: SpeciesReference
stoichiometry: 1.0
species: 326421

089652
type: SpeciesReference
stoichiometry: 1.0
species: 326549

328569
type: Reaction
kinetic law: 112552
product: 112540
reactant: 112528
reactant: 112516
fast: false
reversible: true
name: v827 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2):ATP k123 kd123

112540
type: SpeciesReference
stoichiometry: 1.0
species: 326052

112528
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112516
type: SpeciesReference
stoichiometry: 1.0
species: 326479

328185
type: Reaction
kinetic law: 103290
product: 103278
reactant: 103266
reactant: 103254
fast: false
reversible: true
name: v634 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k68 kd68b

103278
type: SpeciesReference
stoichiometry: 1.0
species: 326721

103266
type: SpeciesReference
stoichiometry: 1.0
species: 326709

103254
type: SpeciesReference
stoichiometry: 1.0
species: 326707

329247
type: Parameter
constant: true
value: 5.0E-5
name: k7

327653
type: Reaction
kinetic law: 091638
product: 091626
reactant: 091613
reactant: 091601
fast: false
reversible: true
name: v363 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091626
type: SpeciesReference
stoichiometry: 1.0
species: 326301

091613
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091601
type: SpeciesReference
stoichiometry: 1.0
species: 326285

327943
type: Reaction
kinetic law: 098441
product: 098429
reactant: 098416
reactant: 098404
fast: false
reversible: true
name: v508 MEK#P#P + ERK#P -> ERK#P:MEK#P#P k52 kd44

098429
type: SpeciesReference
stoichiometry: 1.0
species: 326619

326619
type: Species
notes: ERK#P:MEK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_P:MEK_PP

098416
type: SpeciesReference
stoichiometry: 1.0
species: 326617

098404
type: SpeciesReference
stoichiometry: 1.0
species: 326599

327043
type: Reaction
kinetic law: 077273
product: 077261
reactant: 077249
reactant: 077237
fast: false
reversible: true
name: v49 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4 kd4

077261
type: SpeciesReference
stoichiometry: 1.0
species: 326082

077249
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077237
type: SpeciesReference
stoichiometry: 1.0
species: 326080

326080
type: Species
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

328237
type: Reaction
kinetic law: 104544
product: 104532
reactant: 104520
reactant: 104508
fast: false
reversible: true
name: v660 RTK_Pase + 2(EGF:ErbB1:ATP) -> 2(EGF:ErbB1)#P:RTK_Pase k95 kd95

104532
type: SpeciesReference
stoichiometry: 1.0
species: 326761

104520
type: SpeciesReference
stoichiometry: 1.0
species: 325936

104508
type: SpeciesReference
stoichiometry: 1.0
species: 326755

327437
type: Reaction
kinetic law: 086387
product: 086375
reactant: 086363
reactant: 086351
fast: false
reversible: true
name: v255 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

086375
type: SpeciesReference
stoichiometry: 1.0
species: 326064

086363
type: SpeciesReference
stoichiometry: 1.0
species: 326060

086351
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329307
type: Parameter
constant: true
value: 0.1
name: kd105

327377
type: Reaction
kinetic law: 084938
product: 084926
reactant: 084914
reactant: 084902
fast: false
reversible: true
name: v225 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24

084926
type: SpeciesReference
stoichiometry: 1.0
species: 326096

084914
type: SpeciesReference
stoichiometry: 1.0
species: 326531

084902
type: SpeciesReference
stoichiometry: 1.0
species: 326521

327133
type: Reaction
kinetic law: 079443
product: 079430
reactant: 079418
reactant: 079406
fast: false
reversible: true
name: v98 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4

079430
type: SpeciesReference
stoichiometry: 1.0
species: 326291

079418
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079406
type: SpeciesReference
stoichiometry: 1.0
species: 326289

328001
type: Reaction
kinetic law: 099656
product: 099644
reactant: 099632
fast: false
reversible: true
name: v538 ErbB2 -> R_degraded k60b kd60b

099644
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099632
type: SpeciesReference
stoichiometry: 1.0
species: 325950

327077
type: Reaction
kinetic law: 078093
product: 078081
reactant: 078069
reactant: 078057
fast: false
reversible: true
name: v67 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4

078081
type: SpeciesReference
stoichiometry: 1.0
species: 326150

078069
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078057
type: SpeciesReference
stoichiometry: 1.0
species: 326148

329091
type: Parameter
constant: true
value: 1.5E-6
name: k37

327837
type: Reaction
kinetic law: 095886
product: 095874
reactant: 095862
reactant: 095850
fast: false
reversible: true
name: v455 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37

095874
type: SpeciesReference
stoichiometry: 1.0
species: 326092

095862
type: SpeciesReference
stoichiometry: 1.0
species: 326525

095850
type: SpeciesReference
stoichiometry: 1.0
species: 326503

328587
type: Reaction
kinetic law: 112987
product: 112975
reactant: 112963
reactant: 112951
fast: false
reversible: true
name: v856 EGF:ErbB1:Inh::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k122 kd122

112975
type: SpeciesReference
stoichiometry: 1.0
species: 326941

112963
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112951
type: SpeciesReference
stoichiometry: 1.0
species: 326931

327765
type: Reaction
kinetic law: 094165
product: 094153
reactant: 094141
reactant: 094129
fast: false
reversible: true
name: v419 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094153
type: SpeciesReference
stoichiometry: 1.0
species: 326397

094141
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094129
type: SpeciesReference
stoichiometry: 1.0
species: 326497

326977
type: Reaction
kinetic law: 075662
product: 075649
reactant: 075636
reactant: 075623
fast: false
reversible: true
name: v16 ErbB3 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB3 k2b kd2b

075649
type: SpeciesReference
stoichiometry: 1.0
species: 325964

075636
type: SpeciesReference
stoichiometry: 1.0
species: 325926

075623
type: SpeciesReference
stoichiometry: 1.0
species: 325942

327497
type: Reaction
kinetic law: 087830
product: 087818
reactant: 087806
reactant: 087794
fast: false
reversible: true
name: v285 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

087818
type: SpeciesReference
stoichiometry: 1.0
species: 326297

087806
type: SpeciesReference
stoichiometry: 1.0
species: 326289

087794
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328401
type: Reaction
kinetic law: 108496
product: 108484
reactant: 108472
reactant: 108460
fast: false
reversible: true
name: v742 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111

108484
type: SpeciesReference
stoichiometry: 1.0
species: 326835

326835
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:ERK_PP_i

108472
type: SpeciesReference
stoichiometry: 1.0
species: 326853

108460
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328341
type: Reaction
kinetic law: 107050
product: 107039
reactant: 107027
reactant: 107015
fast: false
reversible: true
name: v712 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107

107039
type: SpeciesReference
stoichiometry: 1.0
species: 326817

107027
type: SpeciesReference
stoichiometry: 1.0
species: 326703

107015
type: SpeciesReference
stoichiometry: 1.0
species: 326805

074794
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

329367
type: Parameter
constant: false
value: 0.0
name: k119

328285
type: Reaction
kinetic law: 105701
product: 105689
reactant: 105677
reactant: 105665
fast: false
reversible: true
name: v684 ErbB2:Inh + ErbB4 -> ErbB4:ErbB2:Inh k103 kd103

105689
type: SpeciesReference
stoichiometry: 1.0
species: 326787

326787
type: Species
notes: ErbB4:ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4:ErbB2:Inh

105677
type: SpeciesReference
stoichiometry: 1.0
species: 325946

105665
type: SpeciesReference
stoichiometry: 1.0
species: 325968

327549
type: Reaction
kinetic law: 089084
product: 089072
reactant: 089060
reactant: 089048
fast: false
reversible: true
name: v311 Ras_activated:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089072
type: SpeciesReference
stoichiometry: 1.0
species: 326269

089060
type: SpeciesReference
stoichiometry: 1.0
species: 326253

089048
type: SpeciesReference
stoichiometry: 1.0
species: 326547

327165
type: Reaction
kinetic law: 080212
product: 080200
reactant: 080188
reactant: 080176
fast: false
reversible: true
name: v114 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b

080200
type: SpeciesReference
stoichiometry: 1.0
species: 326263

080188
type: SpeciesReference
stoichiometry: 1.0
species: 326333

080176
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329033
type: Parameter
constant: true
value: 0.5
name: kd19

328525
type: Reaction
kinetic law: 111456
product: 111444
reactant: 111432
reactant: 111420
fast: false
reversible: true
name: v805 EGF:ErbB1:ErbB1_h:Inh + ATP -> k122 kd122

111444
type: SpeciesReference
stoichiometry: 1.0
species: 326927

111432
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111420
type: SpeciesReference
stoichiometry: 1.0
species: 326915

329101
type: Parameter
constant: true
value: 6.0E-5
name: k42

327629
type: Reaction
kinetic law: 091060
product: 091048
reactant: 091036
reactant: 091024
fast: false
reversible: true
name: v351 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

091048
type: SpeciesReference
stoichiometry: 1.0
species: 326385

091036
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091024
type: SpeciesReference
stoichiometry: 1.0
species: 326397

327855
type: Reaction
kinetic law: 096318
product: 096306
reactant: 096294
reactant: 096282
fast: false
reversible: true
name: v464 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37

096306
type: SpeciesReference
stoichiometry: 1.0
species: 326449

096294
type: SpeciesReference
stoichiometry: 1.0
species: 326523

096282
type: SpeciesReference
stoichiometry: 1.0
species: 326507

328375
type: Reaction
kinetic law: 107870
product: 107858
reactant: 107846
reactant: 107834
fast: false
reversible: true
name: v729 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k110 kd110

107858
type: SpeciesReference
stoichiometry: 1.0
species: 326833

107846
type: SpeciesReference
stoichiometry: 1.0
species: 326683

107834
type: SpeciesReference
stoichiometry: 1.0
species: 326627

328149
type: Reaction
kinetic law: 102422
product: 102410
reactant: 102398
reactant: 102386
fast: false
reversible: true
name: v616 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k65 kd65

102410
type: SpeciesReference
stoichiometry: 1.0
species: 326659

102398
type: SpeciesReference
stoichiometry: 1.0
species: 326669

102386
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327303
type: Reaction
kinetic law: 083239
product: 083227
reactant: 083215
fast: false
reversible: true
name: v187 (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P k7 kd7

083227
type: SpeciesReference
stoichiometry: 1.0
species: 326471

083215
type: SpeciesReference
stoichiometry: 1.0
species: 326469

328961
type: Parameter
constant: true
value: 0.16
name: kd2

329071
type: Parameter
constant: true
value: 4.0E-7
name: k32

327907
type: Reaction
kinetic law: 097573
product: 097561
reactant: 097549
reactant: 097537
fast: false
reversible: true
name: v490 Raf + Pase1 -> (Raf#P:Pase1)_i k43 kd43

097561
type: SpeciesReference
stoichiometry: 1.0
species: 326581

097549
type: SpeciesReference
stoichiometry: 1.0
species: 326579

097537
type: SpeciesReference
stoichiometry: 1.0
species: 326565

328053
type: Reaction
kinetic law: 100593
product: 100581
reactant: 100569
fast: false
reversible: true
name: v566 2(ErbB2) -> R_degraded k60b kd60

100581
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100569
type: SpeciesReference
stoichiometry: 1.0
species: 326643

328513
type: Reaction
kinetic law: 111180
product: 111168
reactant: 111156
reactant: 111144
fast: false
reversible: true
name: v798 EGF + ErbB1_h:ATP -> EGF:ErbB1_h:ATP k1 kd1

111168
type: SpeciesReference
stoichiometry: 1.0
species: 326921

111156
type: SpeciesReference
stoichiometry: 1.0
species: 326919

111144
type: SpeciesReference
stoichiometry: 1.0
species: 325910

327109
type: Reaction
kinetic law: 078863
product: 078851
reactant: 078839
reactant: 078827
fast: false
reversible: true
name: v85 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4

078851
type: SpeciesReference
stoichiometry: 1.0
species: 326243

078839
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078827
type: SpeciesReference
stoichiometry: 1.0
species: 326241

329067
type: Parameter
constant: true
value: 3.1
name: kd29

328999
type: Parameter
constant: true
value: 9.34641E-6
name: k8b

328179
type: Reaction
kinetic law: 103146
product: 103134
reactant: 103122
reactant: 103110
fast: false
reversible: true
name: v631 PIP3 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68

103134
type: SpeciesReference
stoichiometry: 1.0
species: 326715

103122
type: SpeciesReference
stoichiometry: 1.0
species: 326689

103110
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327033
type: Reaction
kinetic law: 077031
product: 077019
reactant: 077007
reactant: 076995
fast: false
reversible: true
name: v44 2(EGF:ErbB1)#P:GAP:Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k4 kd4

077019
type: SpeciesReference
stoichiometry: 1.0
species: 326062

077007
type: SpeciesReference
stoichiometry: 1.0
species: 326056

076995
type: SpeciesReference
stoichiometry: 1.0
species: 326060

328167
type: Reaction
kinetic law: 102858
product: 102846
reactant: 102834
reactant: 102821
fast: false
reversible: true
name: v625 PI3K + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67

102846
type: SpeciesReference
stoichiometry: 1.0
species: 326697

102834
type: SpeciesReference
stoichiometry: 1.0
species: 326695

102821
type: SpeciesReference
stoichiometry: 1.0
species: 326677

326453
type: Species
notes: ErbB2:Inh , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB2:Inh

327677
type: Reaction
kinetic law: 092214
product: 092202
reactant: 092190
reactant: 092178
fast: false
reversible: true
name: v375 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b

092202
type: SpeciesReference
stoichiometry: 1.0
species: 326485

092190
type: SpeciesReference
stoichiometry: 1.0
species: 326481

092178
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327967
type: Reaction
kinetic law: 099018
product: 099006
reactant: 098994
reactant: 098982
fast: false
reversible: true
name: v520 ERK + Pase3 -> (ERK#P:Pase3)_i k57 kd57

099006
type: SpeciesReference
stoichiometry: 1.0
species: 326639

326639
type: Species
notes: (ERK#P:Pase3)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_P:Pase3)_i

098994
type: SpeciesReference
stoichiometry: 1.0
species: 326631

098982
type: SpeciesReference
stoichiometry: 1.0
species: 326613

328487
type: Reaction
kinetic law: 110556
product: 110544
reactant: 110532
reactant: 110520
fast: false
reversible: true
name: v785 ErbB4 + HRG -> HRG:ErbB4 k119 kd119

110544
type: SpeciesReference
stoichiometry: 1.0
species: 326905

110532
type: SpeciesReference
stoichiometry: 1.0
species: 326901

110520
type: SpeciesReference
stoichiometry: 1.0
species: 325946

329005
type: Parameter
constant: true
value: 0.011
name: kd10

327721
type: Reaction
kinetic law: 093104
product: 093092
reactant: 093080
reactant: 093068
fast: false
reversible: true
name: v397 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093092
type: SpeciesReference
stoichiometry: 1.0
species: 326100

093080
type: SpeciesReference
stoichiometry: 1.0
species: 326088

093068
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328241
type: Reaction
kinetic law: 104640
product: 104628
reactant: 104616
reactant: 104604
fast: false
reversible: true
name: v662 RTK_Pase + (ErbB3:ErbB2) -> (ErbB2:ErbB3)#P:RTK_Pase k95 kd95

104628
type: SpeciesReference
stoichiometry: 1.0
species: 326765

104616
type: SpeciesReference
stoichiometry: 1.0
species: 326651

326651
type: Species
notes: (ErbB3:ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)

104604
type: SpeciesReference
stoichiometry: 1.0
species: 326755

328531
type: Reaction
kinetic law: 111600
product: 111588
reactant: 111576
reactant: 111564
fast: false
reversible: true
name: v808 (ErbB1:ErbB2)#P + ATP -> (EGF:ErbB1:ErbB2):ATP k123 kd123

111588
type: SpeciesReference
stoichiometry: 1.0
species: 325982

111576
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111564
type: SpeciesReference
stoichiometry: 1.0
species: 326463

328025
type: Reaction
kinetic law: 100088
product: 100076
reactant: 100064
fast: false
reversible: true
name: v550 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100076
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100064
type: SpeciesReference
stoichiometry: 1.0
species: 326385

329243
type: Parameter
constant: true
value: 0.1
name: kd96

327215
type: Reaction
kinetic law: 081415
product: 081403
reactant: 081391
reactant: 081378
fast: false
reversible: true
name: v142 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b

081403
type: SpeciesReference
stoichiometry: 1.0
species: 326134

081391
type: SpeciesReference
stoichiometry: 1.0
species: 326383

081378
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327381
type: Reaction
kinetic law: 085035
product: 085023
reactant: 085010
reactant: 084998
fast: false
reversible: true
name: v227 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24

085023
type: SpeciesReference
stoichiometry: 1.0
species: 326403

085010
type: SpeciesReference
stoichiometry: 1.0
species: 326535

084998
type: SpeciesReference
stoichiometry: 1.0
species: 326521

329289
type: Parameter
constant: true
value: 8.33E-7
name: k101

328331
type: Reaction
kinetic law: 106810
product: 106798
reactant: 106786
reactant: 106774
fast: false
reversible: true
name: v707 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107

106798
type: SpeciesReference
stoichiometry: 1.0
species: 326807

106786
type: SpeciesReference
stoichiometry: 1.0
species: 326687

106774
type: SpeciesReference
stoichiometry: 1.0
species: 326805

327841
type: Reaction
kinetic law: 095982
product: 095970
reactant: 095958
reactant: 095946
fast: false
reversible: true
name: v457 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

095970
type: SpeciesReference
stoichiometry: 1.0
species: 326405

095958
type: SpeciesReference
stoichiometry: 1.0
species: 326525

095946
type: SpeciesReference
stoichiometry: 1.0
species: 326495

328951
type: Parameter
constant: false
value: 800.0
name: k1c

328425
type: Reaction
kinetic law: 109074
product: 109062
reactant: 109050
reactant: 109038
fast: false
reversible: true
name: v754 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112

109062
type: SpeciesReference
stoichiometry: 1.0
species: 326869

109050
type: SpeciesReference
stoichiometry: 1.0
species: 326685

109038
type: SpeciesReference
stoichiometry: 1.0
species: 326541

328591
type: Reaction
kinetic law: 113083
product: 113071
reactant: 113059
reactant: 113047
fast: false
reversible: true
name: v858 EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k122 kd122

113071
type: SpeciesReference
stoichiometry: 1.0
species: 326945

113059
type: SpeciesReference
stoichiometry: 1.0
species: 325980

113047
type: SpeciesReference
stoichiometry: 1.0
species: 326935

327189
type: Reaction
kinetic law: 080788
product: 080776
reactant: 080764
reactant: 080752
fast: false
reversible: true
name: v127 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b

080776
type: SpeciesReference
stoichiometry: 1.0
species: 326215

080764
type: SpeciesReference
stoichiometry: 1.0
species: 326357

080752
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329163
type: Parameter
constant: true
value: 0.0
name: kd61

326981
type: Reaction
kinetic law: 075766
product: 075753
reactant: 075740
reactant: 075727
fast: false
reversible: true
name: v18 EGF:ErbB1:ATP + ErbB2:Inh -> (EGF:ErbB1:ErbB2):Inh k2b kd2b

075753
type: SpeciesReference
stoichiometry: 1.0
species: 325970

325970
type: Species
has part: P00533
constant: false
initial concentration: NaN
notes: (EGF:ErbB1:ErbB2):Inh , plasma membrane
initial amount: 0.0
boundary condition: false
in compartment: 325898
name: (EGF:ErbB1:ErbB2):Inh
has only substance units: true
has version: P01133

075740
type: SpeciesReference
stoichiometry: 1.0
species: 325968

075727
type: SpeciesReference
stoichiometry: 1.0
species: 325914

327073
type: Reaction
kinetic law: 077997
product: 077985
reactant: 077973
reactant: 077961
fast: false
reversible: true
name: v65 (ErbB1:ErbB3)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k4b kd4

077985
type: SpeciesReference
stoichiometry: 1.0
species: 326142

326142
type: Species
notes: (ErbB1:ErbB3)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:cPP

077973
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077961
type: SpeciesReference
stoichiometry: 1.0
species: 326140

327009
type: Reaction
kinetic law: 076451
product: 076439
reactant: 076427
reactant: 076415
fast: false
reversible: true
name: v32 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k122 kd122

076439
type: SpeciesReference
stoichiometry: 1.0
species: 326012

326012
type: Species
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1:ATP

076427
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076415
type: SpeciesReference
stoichiometry: 1.0
species: 326010

327879
type: Reaction
kinetic law: 096896
product: 096884
reactant: 096872
reactant: 096860
fast: false
reversible: true
name: v476 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

096884
type: SpeciesReference
stoichiometry: 1.0
species: 326104

096872
type: SpeciesReference
stoichiometry: 1.0
species: 326529

096860
type: SpeciesReference
stoichiometry: 1.0
species: 326577

328399
type: Reaction
kinetic law: 108448
product: 108436
reactant: 108424
reactant: 108412
fast: false
reversible: true
name: v741 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k111 kd111

108436
type: SpeciesReference
stoichiometry: 1.0
species: 326833

108424
type: SpeciesReference
stoichiometry: 1.0
species: 326853

108412
type: SpeciesReference
stoichiometry: 1.0
species: 326627

328985
type: Parameter
constant: true
value: 0.0080833
name: kd5b

327233
type: Reaction
kinetic law: 081853
product: 081841
reactant: 081829
reactant: 081817
fast: false
reversible: true
name: v151 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b

081841
type: SpeciesReference
stoichiometry: 1.0
species: 326098

326098
type: Species
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:cPP

081829
type: SpeciesReference
stoichiometry: 1.0
species: 326401

081817
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329095
type: Parameter
constant: true
value: 0.064
name: kd40

327493
type: Reaction
kinetic law: 087734
product: 087722
reactant: 087710
reactant: 087698
fast: false
reversible: true
name: v283 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

087722
type: SpeciesReference
stoichiometry: 1.0
species: 326293

326293
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)

087710
type: SpeciesReference
stoichiometry: 1.0
species: 326285

087698
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328077
type: Reaction
kinetic law: 101025
product: 101013
reactant: 101001
fast: false
reversible: true
name: v580 (ErbB4:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60

101013
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101001
type: SpeciesReference
stoichiometry: 1.0
species: 326447

328443
type: Reaction
kinetic law: 109507
product: 109495
reactant: 109483
reactant: 109471
fast: false
reversible: true
name: v763 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113

109495
type: SpeciesReference
stoichiometry: 1.0
species: 326873

109483
type: SpeciesReference
stoichiometry: 1.0
species: 326701

109471
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328217
type: Reaction
kinetic law: 104060
product: 104048
reactant: 104036
reactant: 104024
fast: false
reversible: true
name: v650 RTK_Pase + (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P:RTK_Pase k94b kd94

104048
type: SpeciesReference
stoichiometry: 1.0
species: 326757

104036
type: SpeciesReference
stoichiometry: 1.0
species: 326467

104024
type: SpeciesReference
stoichiometry: 1.0
species: 326755

329253
type: Parameter
constant: true
value: 0.0
name: kd60b

327953
type: Reaction
kinetic law: 098681
product: 098669
reactant: 098657
reactant: 098645
fast: false
reversible: true
name: v513 ERK#P#P + MEK#P#P -> ERK#P:MEK#P#P k55 kd55

098669
type: SpeciesReference
stoichiometry: 1.0
species: 326619

098657
type: SpeciesReference
stoichiometry: 1.0
species: 326599

098645
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327541
type: Reaction
kinetic law: 088892
product: 088880
reactant: 088868
reactant: 088856
fast: false
reversible: true
name: v307 Ras:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088880
type: SpeciesReference
stoichiometry: 1.0
species: 326257

088868
type: SpeciesReference
stoichiometry: 1.0
species: 326277

088856
type: SpeciesReference
stoichiometry: 1.0
species: 326543

327911
type: Reaction
kinetic law: 097669
product: 097657
reactant: 097645
reactant: 097633
fast: false
reversible: true
name: v492 MEK + (Raf#P)_i -> (MEK:Raf#P)_i k44 kd52

097657
type: SpeciesReference
stoichiometry: 1.0
species: 326591

097645
type: SpeciesReference
stoichiometry: 1.0
species: 326571

097633
type: SpeciesReference
stoichiometry: 1.0
species: 326589

328111
type: Reaction
kinetic law: 101639
product: 101627
reactant: 101615
fast: false
reversible: true
name: v597 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60

101627
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101615
type: SpeciesReference
stoichiometry: 1.0
species: 326313

328307
type: Reaction
kinetic law: 106232
product: 106220
reactant: 106208
reactant: 106196
fast: false
reversible: true
name: v695 PIP2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b

106220
type: SpeciesReference
stoichiometry: 1.0
species: 326713

326713
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1_P:PI3K:PIP2

106208
type: SpeciesReference
stoichiometry: 1.0
species: 326681

106196
type: SpeciesReference
stoichiometry: 1.0
species: 326793

328141
type: Reaction
kinetic law: 102230
product: 102218
reactant: 102206
reactant: 102194
fast: false
reversible: true
name: v612 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k64 kd64

102218
type: SpeciesReference
stoichiometry: 1.0
species: 326661

102206
type: SpeciesReference
stoichiometry: 1.0
species: 326411

102194
type: SpeciesReference
stoichiometry: 1.0
species: 326629

327057
type: Reaction
kinetic law: 077611
product: 077599
reactant: 077587
reactant: 077574
fast: false
reversible: true
name: v57 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4

077599
type: SpeciesReference
stoichiometry: 1.0
species: 326110

077587
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077574
type: SpeciesReference
stoichiometry: 1.0
species: 326108

327817
type: Reaction
kinetic law: 095405
product: 095393
reactant: 095381
reactant: 095369
fast: false
reversible: true
name: v445 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37

095393
type: SpeciesReference
stoichiometry: 1.0
species: 326072

095381
type: SpeciesReference
stoichiometry: 1.0
species: 326525

095369
type: SpeciesReference
stoichiometry: 1.0
species: 326429

328927
type: Parameter
constant: false
units: item
value: NaN
name: total ERB-B1_P

327405
type: Reaction
kinetic law: 085615
product: 085603
reactant: 085591
reactant: 085579
fast: false
reversible: true
name: v239 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd24

085603
type: SpeciesReference
stoichiometry: 1.0
species: 326281

085591
type: SpeciesReference
stoichiometry: 1.0
species: 326521

085579
type: SpeciesReference
stoichiometry: 1.0
species: 326509

326112
type: Species
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)

327345
type: Reaction
kinetic law: 084180
product: 084168
reactant: 084156
reactant: 084144
fast: false
reversible: true
name: v208 ErbB1:ATP + EGF -> EGF:ErbB1:ATP k10b kd10

084168
type: SpeciesReference
stoichiometry: 1.0
species: 325934

084156
type: SpeciesReference
stoichiometry: 1.0
species: 326515

084144
type: SpeciesReference
stoichiometry: 1.0
species: 326423

329173
type: Parameter
constant: true
value: 0.0
name: k65

327805
type: Reaction
kinetic law: 095129
product: 095117
reactant: 095105
reactant: 095093
fast: false
reversible: true
name: v439 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34

095117
type: SpeciesReference
stoichiometry: 1.0
species: 326321

095105
type: SpeciesReference
stoichiometry: 1.0
species: 326577

095093
type: SpeciesReference
stoichiometry: 1.0
species: 326511

327101
type: Reaction
kinetic law: 078670
product: 078658
reactant: 078646
reactant: 078634
fast: false
reversible: true
name: v81 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4

078658
type: SpeciesReference
stoichiometry: 1.0
species: 326227

078646
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078634
type: SpeciesReference
stoichiometry: 1.0
species: 326225

326225
type: Species
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)

326957
type: Reaction
kinetic law: 075169
product: 075157
reactant: 075145
reactant: 075133
fast: false
reversible: true
name: v6 EGF:ErbB1:Inh + EGF:ErbB1:Inh -> 2(EGF:ErbB1:Inh) k2 kd2

075157
type: SpeciesReference
stoichiometry: 1.0
species: 325930

075145
type: SpeciesReference
stoichiometry: 1.0
species: 325926

075133
type: SpeciesReference
stoichiometry: 1.0
species: 325926

326044
type: Species
notes: (HRG:ErbB3):ErbB2:ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB3):ErbB2:ATP

327971
type: Reaction
kinetic law: 099115
product: 099103
reactant: 099091
reactant: 099079
fast: false
reversible: true
name: v522 Pase3 + (ERK#P)_i -> (ERK#P:Pase3)_i k58 kd58

099103
type: SpeciesReference
stoichiometry: 1.0
species: 326639

099091
type: SpeciesReference
stoichiometry: 1.0
species: 326623

099079
type: SpeciesReference
stoichiometry: 1.0
species: 326631

329271
type: Parameter
constant: true
value: 3.0E-7
name: Kinh2

328555
type: Reaction
kinetic law: 112197
product: 112184
reactant: 112170
reactant: 112157
fast: false
reversible: true
name: v820 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123

112184
type: SpeciesReference
stoichiometry: 1.0
species: 326024

112170
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112157
type: SpeciesReference
stoichiometry: 1.0
species: 326703

328171
type: Reaction
kinetic law: 102954
product: 102942
reactant: 102930
reactant: 102918
fast: false
reversible: true
name: v627 PI3K + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66

102942
type: SpeciesReference
stoichiometry: 1.0
species: 326705

102930
type: SpeciesReference
stoichiometry: 1.0
species: 326703

102918
type: SpeciesReference
stoichiometry: 1.0
species: 326677

327209
type: Reaction
kinetic law: 081269
product: 081257
reactant: 081245
reactant: 081233
fast: false
reversible: true
name: v139 cPP + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k5 kd5b

081257
type: SpeciesReference
stoichiometry: 1.0
species: 326146

081245
type: SpeciesReference
stoichiometry: 1.0
species: 326377

081233
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329127
type: Parameter
constant: true
value: 4.74801E-8
name: k50

327465
type: Reaction
kinetic law: 087060
product: 087048
reactant: 087036
reactant: 087024
fast: false
reversible: true
name: v269 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087048
type: SpeciesReference
stoichiometry: 1.0
species: 326373

087036
type: SpeciesReference
stoichiometry: 1.0
species: 326361

087024
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327609
type: Reaction
kinetic law: 090579
product: 090566
reactant: 090554
reactant: 090542
fast: false
reversible: true
name: v341 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

090566
type: SpeciesReference
stoichiometry: 1.0
species: 326225

090554
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090542
type: SpeciesReference
stoichiometry: 1.0
species: 326217

328419
type: Reaction
kinetic law: 108930
product: 108918
reactant: 108906
reactant: 108893
fast: false
reversible: true
name: v751 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k112 kd112

108918
type: SpeciesReference
stoichiometry: 1.0
species: 326863

108906
type: SpeciesReference
stoichiometry: 1.0
species: 326681

108893
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329335
type: Parameter
constant: true
value: 0.0
name: k111

327779
type: Reaction
kinetic law: 094501
product: 094489
reactant: 094477
reactant: 094465
fast: false
reversible: true
name: v426 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094489
type: SpeciesReference
stoichiometry: 1.0
species: 326337

094477
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094465
type: SpeciesReference
stoichiometry: 1.0
species: 326513

327517
type: Reaction
kinetic law: 088312
product: 088300
reactant: 088288
reactant: 088276
fast: false
reversible: true
name: v295 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088300
type: SpeciesReference
stoichiometry: 1.0
species: 326112

088288
type: SpeciesReference
stoichiometry: 1.0
species: 326543

088276
type: SpeciesReference
stoichiometry: 1.0
species: 326100

327865
type: Reaction
kinetic law: 096560
product: 096548
reactant: 096536
reactant: 096524
fast: false
reversible: true
name: v469 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

096548
type: SpeciesReference
stoichiometry: 1.0
species: 326341

096536
type: SpeciesReference
stoichiometry: 1.0
species: 326525

096524
type: SpeciesReference
stoichiometry: 1.0
species: 326511

328299
type: Reaction
kinetic law: 106039
product: 106027
reactant: 106015
reactant: 106003
fast: false
reversible: true
name: v691 (ErbB1:ErbB4)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 k105 kd105

106027
type: SpeciesReference
stoichiometry: 1.0
species: 326010

106015
type: SpeciesReference
stoichiometry: 1.0
species: 326801

106003
type: SpeciesReference
stoichiometry: 1.0
species: 326144

327453
type: Reaction
kinetic law: 086772
product: 086760
reactant: 086748
reactant: 086736
fast: false
reversible: true
name: v263 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086760
type: SpeciesReference
stoichiometry: 1.0
species: 326391

086748
type: SpeciesReference
stoichiometry: 1.0
species: 326397

086736
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329001
type: Parameter
constant: true
value: 140000.0
name: k10

328937
type: Parameter
constant: true
units: item
value: 1080000.0
name: total EGF receptor

327917
type: Reaction
kinetic law: 097814
product: 097802
reactant: 097790
reactant: 097778
fast: false
reversible: true
name: v495 MEK#P + Raf#P -> MEK:Raf#P k45 kd45

097802
type: SpeciesReference
stoichiometry: 1.0
species: 326593

097790
type: SpeciesReference
stoichiometry: 1.0
species: 326573

097778
type: SpeciesReference
stoichiometry: 1.0
species: 326595

327823
type: Reaction
kinetic law: 095549
product: 095537
reactant: 095525
reactant: 095513
fast: false
reversible: true
name: v448 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37

095537
type: SpeciesReference
stoichiometry: 1.0
species: 326527

095525
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095513
type: SpeciesReference
stoichiometry: 1.0
species: 326501

328117
type: Reaction
kinetic law: 101748
product: 101736
reactant: 101724
fast: false
reversible: true
name: v600 (EGF:ErbB1:ErbB2) -> R_degraded k62b kd60b

101736
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101724
type: SpeciesReference
stoichiometry: 1.0
species: 325952

329047
type: Parameter
constant: true
value: 6.0
name: k23

329187
type: Parameter
notes: %PIP3 dissociates from PI3K
constant: true
value: 20.5
name: kd68b

328021
type: Reaction
kinetic law: 100016
product: 100004
reactant: 099992
fast: false
reversible: true
name: v548 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

100004
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099992
type: SpeciesReference
stoichiometry: 1.0
species: 326389

327097
type: Reaction
kinetic law: 078574
product: 078562
reactant: 078550
reactant: 078538
fast: false
reversible: true
name: v79 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4

078562
type: SpeciesReference
stoichiometry: 1.0
species: 326219

078550
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078538
type: SpeciesReference
stoichiometry: 1.0
species: 326217

327257
type: Reaction
kinetic law: 082406
product: 082394
reactant: 082382
fast: false
reversible: true
name: v164 ErbB1:ATP -> ErbB1:ATP k6 kd6

082394
type: SpeciesReference
stoichiometry: 1.0
species: 326423

082382
type: SpeciesReference
stoichiometry: 1.0
species: 325912

328067
type: Reaction
kinetic law: 100844
product: 100832
reactant: 100820
fast: false
reversible: true
name: v574 2(ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60

100832
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100820
type: SpeciesReference
stoichiometry: 1.0
species: 326349

327013
type: Reaction
kinetic law: 076547
product: 076535
reactant: 076523
reactant: 076511
fast: false
reversible: true
name: v34 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122

076535
type: SpeciesReference
stoichiometry: 1.0
species: 326020

076523
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076511
type: SpeciesReference
stoichiometry: 1.0
species: 326018

328271
type: Reaction
kinetic law: 105364
product: 105352
reactant: 105340
reactant: 105327
fast: false
reversible: true
name: v677 ErbB2#P + ErbB2 -> ErbB2:ErbB2#P k103 kd103

105352
type: SpeciesReference
stoichiometry: 1.0
species: 325998

105340
type: SpeciesReference
stoichiometry: 1.0
species: 325938

105327
type: SpeciesReference
stoichiometry: 1.0
species: 326771

327947
type: Reaction
kinetic law: 098537
product: 098525
reactant: 098513
reactant: 098501
fast: false
reversible: true
name: v510 (MEK#P#P)_i + (ERK#P)_i -> MEK#P#P:ERK#P k52 kd44

098525
type: SpeciesReference
stoichiometry: 1.0
species: 326625

098513
type: SpeciesReference
stoichiometry: 1.0
species: 326623

098501
type: SpeciesReference
stoichiometry: 1.0
species: 326601

328207
type: Reaction
kinetic law: 103820
product: 103808
reactant: 103796
reactant: 103784
fast: false
reversible: true
name: v645 AKT#P#P + Pase4 -> AKT#P#P:Pase4 k74 kd74

103808
type: SpeciesReference
stoichiometry: 1.0
species: 326751

103796
type: SpeciesReference
stoichiometry: 1.0
species: 326749

103784
type: SpeciesReference
stoichiometry: 1.0
species: 326747

327309
type: Reaction
kinetic law: 083347
product: 083335
reactant: 083323
fast: false
reversible: true
name: v190 (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P k7 kd7

083335
type: SpeciesReference
stoichiometry: 1.0
species: 326479

083323
type: SpeciesReference
stoichiometry: 1.0
species: 325922

327883
type: Reaction
kinetic law: 096993
product: 096981
reactant: 096969
reactant: 096957
fast: false
reversible: true
name: v478 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

096981
type: SpeciesReference
stoichiometry: 1.0
species: 326399

096969
type: SpeciesReference
stoichiometry: 1.0
species: 326533

096957
type: SpeciesReference
stoichiometry: 1.0
species: 326577

329383
type: Parameter
constant: false
value: 1.0
name: kd122

328467
type: Reaction
kinetic law: 110074
product: 110061
reactant: 110049
reactant: 110036
fast: false
reversible: true
name: v775 Pase9t + ErbB1:ErbB:Gab1#P## -> ErbB1:ErbB:Gab1#P##:Pase9t k117 kd117

110061
type: SpeciesReference
stoichiometry: 1.0
species: 326897

110049
type: SpeciesReference
stoichiometry: 1.0
species: 326857

110036
type: SpeciesReference
stoichiometry: 1.0
species: 326885

329209
type: Parameter
constant: false
value: 6.36184E-7
name: k74

327935
type: Reaction
kinetic law: 098248
product: 098235
reactant: 098223
reactant: 098211
fast: false
reversible: true
name: v504 (MEK#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k49 kd49

098235
type: SpeciesReference
stoichiometry: 1.0
species: 326605

098223
type: SpeciesReference
stoichiometry: 1.0
species: 326603

098211
type: SpeciesReference
stoichiometry: 1.0
species: 326585

328955
type: Parameter
constant: false
value: 0.1
name: kd1d

327565
type: Reaction
kinetic law: 089482
product: 089469
reactant: 089456
reactant: 089443
fast: false
reversible: true
name: v319 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089469
type: SpeciesReference
stoichiometry: 1.0
species: 326367

089456
type: SpeciesReference
stoichiometry: 1.0
species: 326361

089443
type: SpeciesReference
stoichiometry: 1.0
species: 326549

327181
type: Reaction
kinetic law: 080596
product: 080584
reactant: 080572
reactant: 080560
fast: false
reversible: true
name: v123 cPP + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:cPP k5 kd5b

080584
type: SpeciesReference
stoichiometry: 1.0
species: 326231

326231
type: Species
notes: 2(ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:cPP

080572
type: SpeciesReference
stoichiometry: 1.0
species: 326349

080560
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329349
type: Parameter
constant: true
value: 0.0
name: k115

328519
type: Reaction
kinetic law: 111312
product: 111300
reactant: 111288
reactant: 111276
fast: false
reversible: true
name: v802 (EGF:ErbB1:ErbB1):Inh + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k122 kd122

111300
type: SpeciesReference
stoichiometry: 1.0
species: 326925

111288
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111276
type: SpeciesReference
stoichiometry: 1.0
species: 325928

328135
type: Reaction
kinetic law: 102086
product: 102074
reactant: 102062
reactant: 102050
fast: false
reversible: true
name: v609 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64

102074
type: SpeciesReference
stoichiometry: 1.0
species: 326655

102062
type: SpeciesReference
stoichiometry: 1.0
species: 326060

102050
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327645
type: Reaction
kinetic law: 091444
product: 091432
reactant: 091420
reactant: 091408
fast: false
reversible: true
name: v359 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

091432
type: SpeciesReference
stoichiometry: 1.0
species: 326265

091420
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091408
type: SpeciesReference
stoichiometry: 1.0
species: 326277

329011
type: Parameter
constant: true
value: 0.0
name: k14

328391
type: Reaction
kinetic law: 108254
product: 108242
reactant: 108230
reactant: 108218
fast: false
reversible: true
name: v737 ERK#P#P + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111

108242
type: SpeciesReference
stoichiometry: 1.0
species: 326841

108230
type: SpeciesReference
stoichiometry: 1.0
species: 326849

108218
type: SpeciesReference
stoichiometry: 1.0
species: 326627

328165
type: Reaction
kinetic law: 102809
product: 102797
reactant: 102785
reactant: 102773
fast: false
reversible: true
name: v624 PI3K + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67

102797
type: SpeciesReference
stoichiometry: 1.0
species: 326693

102785
type: SpeciesReference
stoichiometry: 1.0
species: 326691

102773
type: SpeciesReference
stoichiometry: 1.0
species: 326677

327429
type: Reaction
kinetic law: 086195
product: 086183
reactant: 086171
reactant: 086159
fast: false
reversible: true
name: v251 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17

086183
type: SpeciesReference
stoichiometry: 1.0
species: 326209

086171
type: SpeciesReference
stoichiometry: 1.0
species: 326144

086159
type: SpeciesReference
stoichiometry: 1.0
species: 326539

326763
type: Species
notes: 2(ErbB2)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:RTK_Pase

327595
type: Reaction
kinetic law: 090240
product: 090228
reactant: 090216
reactant: 090204
fast: false
reversible: true
name: v334 2(ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

090228
type: SpeciesReference
stoichiometry: 1.0
species: 326343

090216
type: SpeciesReference
stoichiometry: 1.0
species: 326549

090204
type: SpeciesReference
stoichiometry: 1.0
species: 326347

327369
type: Reaction
kinetic law: 084746
product: 084734
reactant: 084722
reactant: 084710
fast: false
reversible: true
name: v221 (ErbB1:ErbB3)#P:GAP + Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24

084734
type: SpeciesReference
stoichiometry: 1.0
species: 326379

084722
type: SpeciesReference
stoichiometry: 1.0
species: 326521

084710
type: SpeciesReference
stoichiometry: 1.0
species: 326497

327735
type: Reaction
kinetic law: 093440
product: 093428
reactant: 093416
reactant: 093404
fast: false
reversible: true
name: v404 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093428
type: SpeciesReference
stoichiometry: 1.0
species: 326355

093416
type: SpeciesReference
stoichiometry: 1.0
species: 326357

093404
type: SpeciesReference
stoichiometry: 1.0
species: 326539

327125
type: Reaction
kinetic law: 079249
product: 079237
reactant: 079225
reactant: 079213
fast: false
reversible: true
name: v94 (ErbB3:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k4b kd4

079237
type: SpeciesReference
stoichiometry: 1.0
species: 326275

326275
type: Species
notes: (ErbB3:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:cPP

079225
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079213
type: SpeciesReference
stoichiometry: 1.0
species: 326273

328255
type: Reaction
kinetic law: 104977
product: 104965
reactant: 104953
reactant: 104941
fast: false
reversible: true
name: v669 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P k101 kd101

104965
type: SpeciesReference
stoichiometry: 1.0
species: 326667

104953
type: SpeciesReference
stoichiometry: 1.0
species: 326054

104941
type: SpeciesReference
stoichiometry: 1.0
species: 326671

327995
type: Reaction
kinetic law: 099548
product: 099536
reactant: 099524
fast: false
reversible: true
name: v534 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60

099536
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099524
type: SpeciesReference
stoichiometry: 1.0
species: 326409

327583
type: Reaction
kinetic law: 089950
product: 089938
reactant: 089925
reactant: 089913
fast: false
reversible: true
name: v328 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089938
type: SpeciesReference
stoichiometry: 1.0
species: 326387

089925
type: SpeciesReference
stoichiometry: 1.0
species: 326399

089913
type: SpeciesReference
stoichiometry: 1.0
species: 326549

328579
type: Reaction
kinetic law: 112795
product: 112783
reactant: 112771
reactant: 112759
fast: false
reversible: true
name: v852 EGF:ErbB1_h:ATP + EGF:ErbB1_h:ATP -> 2(EGF:ErbB1_h:ATP) k2 kd2

112783
type: SpeciesReference
stoichiometry: 1.0
species: 326933

112771
type: SpeciesReference
stoichiometry: 1.0
species: 326921

112759
type: SpeciesReference
stoichiometry: 1.0
species: 326921

328195
type: Reaction
kinetic law: 103531
product: 103519
reactant: 103507
reactant: 103495
fast: false
reversible: true
name: v639 PIP3 + AKT -> PIP3:AKT k69 kd69

103519
type: SpeciesReference
stoichiometry: 1.0
species: 326733

103507
type: SpeciesReference
stoichiometry: 1.0
species: 326731

103495
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327459
type: Reaction
kinetic law: 086916
product: 086904
reactant: 086892
reactant: 086880
fast: false
reversible: true
name: v266 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

086904
type: SpeciesReference
stoichiometry: 1.0
species: 326152

086892
type: SpeciesReference
stoichiometry: 1.0
species: 326205

086880
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329257
type: Parameter
constant: true
value: 0.0471248
name: k60b

327293
type: Reaction
kinetic law: 083057
product: 083045
reactant: 083033
fast: false
reversible: true
name: v182 ErbB2:Inh -> ErbB2:Inh k6b kd6b

083045
type: SpeciesReference
stoichiometry: 1.0
species: 326453

083033
type: SpeciesReference
stoichiometry: 1.0
species: 325968

327053
type: Reaction
kinetic law: 077514
product: 077502
reactant: 077490
reactant: 077478
fast: false
reversible: true
name: v55 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4

077502
type: SpeciesReference
stoichiometry: 1.0
species: 326102

077490
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077478
type: SpeciesReference
stoichiometry: 1.0
species: 326100

327489
type: Reaction
kinetic law: 087638
product: 087626
reactant: 087614
reactant: 087602
fast: false
reversible: true
name: v281 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087626
type: SpeciesReference
stoichiometry: 1.0
species: 326293

087614
type: SpeciesReference
stoichiometry: 1.0
species: 326285

087602
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329359
type: Parameter
constant: true
value: 0.1
name: kd117

327157
type: Reaction
kinetic law: 080020
product: 080008
reactant: 079996
reactant: 079984
fast: false
reversible: true
name: v110 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b

080008
type: SpeciesReference
stoichiometry: 1.0
species: 326279

079996
type: SpeciesReference
stoichiometry: 1.0
species: 326325

079984
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327143
type: Reaction
kinetic law: 079684
product: 079672
reactant: 079660
reactant: 079648
fast: false
reversible: true
name: v103 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b

079672
type: SpeciesReference
stoichiometry: 1.0
species: 326307

079660
type: SpeciesReference
stoichiometry: 1.0
species: 326311

079648
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327847
type: Reaction
kinetic law: 096126
product: 096114
reactant: 096102
reactant: 096090
fast: false
reversible: true
name: v460 2(ErbB2)#P:GAP + (Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k37 kd37

096114
type: SpeciesReference
stoichiometry: 1.0
species: 326489

096102
type: SpeciesReference
stoichiometry: 1.0
species: 326523

096090
type: SpeciesReference
stoichiometry: 1.0
species: 326481

328367
type: Reaction
kinetic law: 107678
product: 107666
reactant: 107654
reactant: 107642
fast: false
reversible: true
name: v725 ERK#P#P + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110

107666
type: SpeciesReference
stoichiometry: 1.0
species: 326825

107654
type: SpeciesReference
stoichiometry: 1.0
species: 326687

107642
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327521
type: Reaction
kinetic law: 088408
product: 088396
reactant: 088384
reactant: 088372
fast: false
reversible: true
name: v297 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088396
type: SpeciesReference
stoichiometry: 1.0
species: 326120

088384
type: SpeciesReference
stoichiometry: 1.0
species: 326543

088372
type: SpeciesReference
stoichiometry: 1.0
species: 326108

327201
type: Reaction
kinetic law: 081077
product: 081065
reactant: 081053
reactant: 081041
fast: false
reversible: true
name: v135 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b

081065
type: SpeciesReference
stoichiometry: 1.0
species: 326191

326191
type: Species
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP

081053
type: SpeciesReference
stoichiometry: 1.0
species: 326369

081041
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329063
type: Parameter
constant: true
value: 0.0053
name: kd28b

327461
type: Reaction
kinetic law: 086964
product: 086952
reactant: 086940
reactant: 086928
fast: false
reversible: true
name: v267 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

086952
type: SpeciesReference
stoichiometry: 1.0
species: 326156

086940
type: SpeciesReference
stoichiometry: 1.0
species: 326209

086928
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327601
type: Reaction
kinetic law: 090384
product: 090372
reactant: 090360
reactant: 090348
fast: false
reversible: true
name: v337 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

090372
type: SpeciesReference
stoichiometry: 1.0
species: 326301

090360
type: SpeciesReference
stoichiometry: 1.0
species: 326547

090348
type: SpeciesReference
stoichiometry: 1.0
species: 326285

328121
type: Reaction
kinetic law: 101821
product: 101809
reactant: 101797
fast: false
reversible: true
name: v602 (EGF:ErbB1:ErbB4) -> R_degraded k62b kd60b

101809
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101797
type: SpeciesReference
stoichiometry: 1.0
species: 325960

326987
type: Reaction
kinetic law: 075922
product: 075910
reactant: 075897
reactant: 075885
fast: false
reversible: true
name: v21 (EGF:ErbB1:ErbB2) + ATP -> (EGF:ErbB1:ErbB2):ATP k122 kd122

075910
type: SpeciesReference
stoichiometry: 1.0
species: 325982

075897
type: SpeciesReference
stoichiometry: 1.0
species: 325980

075885
type: SpeciesReference
stoichiometry: 1.0
species: 325952

328411
type: Reaction
kinetic law: 108736
product: 108724
reactant: 108712
reactant: 108700
fast: false
reversible: true
name: v747 ERK#P#P + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k111 kd111

108724
type: SpeciesReference
stoichiometry: 1.0
species: 326821

326821
type: Species
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):ERK_PP

108712
type: SpeciesReference
stoichiometry: 1.0
species: 326859

108700
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327771
type: Reaction
kinetic law: 094309
product: 094297
reactant: 094285
reactant: 094273
fast: false
reversible: true
name: v422 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094297
type: SpeciesReference
stoichiometry: 1.0
species: 326355

094285
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094273
type: SpeciesReference
stoichiometry: 1.0
species: 326483

328295
type: Reaction
kinetic law: 105943
product: 105931
reactant: 105919
reactant: 105907
fast: false
reversible: true
name: v689 (ErbB1:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105

105931
type: SpeciesReference
stoichiometry: 1.0
species: 326002

105919
type: SpeciesReference
stoichiometry: 1.0
species: 326801

105907
type: SpeciesReference
stoichiometry: 1.0
species: 326136

074878
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

074866
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM

327559
type: Reaction
kinetic law: 089327
product: 089315
reactant: 089302
reactant: 089289
fast: false
reversible: true
name: v316 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20

089315
type: SpeciesReference
stoichiometry: 1.0
species: 326193

089302
type: SpeciesReference
stoichiometry: 1.0
species: 326547

089289
type: SpeciesReference
stoichiometry: 1.0
species: 326205

329267
type: Parameter
constant: false
value: 1000000.0
name: k97c

327325
type: Reaction
kinetic law: 083697
product: 083685
reactant: 083673
reactant: 083661
fast: false
reversible: true
name: v198 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8

083685
type: SpeciesReference
stoichiometry: 1.0
species: 326429

083673
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083661
type: SpeciesReference
stoichiometry: 1.0
species: 326425

327261
type: Reaction
kinetic law: 082479
product: 082467
reactant: 082455
fast: false
reversible: true
name: v166 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP k6 kd6

082467
type: SpeciesReference
stoichiometry: 1.0
species: 326431

082455
type: SpeciesReference
stoichiometry: 1.0
species: 326429

328071
type: Reaction
kinetic law: 100917
product: 100905
reactant: 100892
fast: false
reversible: true
name: v576 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

100905
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100892
type: SpeciesReference
stoichiometry: 1.0
species: 326345

327635
type: Reaction
kinetic law: 091204
product: 091192
reactant: 091180
reactant: 091168
fast: false
reversible: true
name: v354 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091192
type: SpeciesReference
stoichiometry: 1.0
species: 326193

091180
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091168
type: SpeciesReference
stoichiometry: 1.0
species: 326205

327589
type: Reaction
kinetic law: 090095
product: 090083
reactant: 090071
reactant: 090059
fast: false
reversible: true
name: v331 Ras_activated:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

090083
type: SpeciesReference
stoichiometry: 1.0
species: 326225

090071
type: SpeciesReference
stoichiometry: 1.0
species: 326217

090059
type: SpeciesReference
stoichiometry: 1.0
species: 326547

327025
type: Reaction
kinetic law: 076838
product: 076826
reactant: 076814
reactant: 076802
fast: false
reversible: true
name: v40 (HRG:ErbB3):ErbB2 + ATP -> (HRG:ErbB3):ErbB2:ATP k122 kd122

076826
type: SpeciesReference
stoichiometry: 1.0
species: 326044

076814
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076802
type: SpeciesReference
stoichiometry: 1.0
species: 326042

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

328211
type: Reaction
kinetic law: 103916
product: 103904
reactant: 103892
reactant: 103880
fast: false
reversible: true
name: v647 AKT + Pase4 -> AKT#P:Pase4 k75 kd75

103904
type: SpeciesReference
stoichiometry: 1.0
species: 326753

103892
type: SpeciesReference
stoichiometry: 1.0
species: 326749

103880
type: SpeciesReference
stoichiometry: 1.0
species: 326731

328535
type: Reaction
kinetic law: 111696
product: 111684
reactant: 111672
reactant: 111660
fast: false
reversible: true
name: v810 (ErbB1:ErbB4)#P + ATP -> (EGF:ErbB1:ErbB4):ATP k123 kd123

111684
type: SpeciesReference
stoichiometry: 1.0
species: 325986

111672
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111660
type: SpeciesReference
stoichiometry: 1.0
species: 326471

328159
type: Reaction
kinetic law: 102664
product: 102651
reactant: 102639
reactant: 102627
fast: false
reversible: true
name: v621 PI3K + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66

102651
type: SpeciesReference
stoichiometry: 1.0
species: 326681

102639
type: SpeciesReference
stoichiometry: 1.0
species: 326679

102627
type: SpeciesReference
stoichiometry: 1.0
species: 326677

327313
type: Reaction
kinetic law: 083419
product: 083407
reactant: 083395
fast: false
reversible: true
name: v192 2(ErbB2)#P:GAP:Shc -> 2(ErbB2)#P:GAP:Shc k7 kd7

083407
type: SpeciesReference
stoichiometry: 1.0
species: 326487

083395
type: SpeciesReference
stoichiometry: 1.0
species: 326485

328971
type: Parameter
constant: true
value: 6.73E-6
name: k4

327895
type: Reaction
kinetic law: 097284
product: 097272
reactant: 097259
reactant: 097247
fast: false
reversible: true
name: v484 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097272
type: SpeciesReference
stoichiometry: 1.0
species: 326325

097259
type: SpeciesReference
stoichiometry: 1.0
species: 326451

097247
type: SpeciesReference
stoichiometry: 1.0
species: 326577

329141
type: Parameter
constant: false
value: 5.0
name: kd56

328471
type: Reaction
kinetic law: 110171
product: 110159
reactant: 110147
reactant: 110135
fast: false
reversible: true
name: v777 Pase9t + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1):Gab1#P##:Pase9t k118 kd118

110159
type: SpeciesReference
stoichiometry: 1.0
species: 326887

110147
type: SpeciesReference
stoichiometry: 1.0
species: 326679

110135
type: SpeciesReference
stoichiometry: 1.0
species: 326885

329107
type: Parameter
constant: true
value: 0.0
name: k43

327119
type: Reaction
kinetic law: 079104
product: 079092
reactant: 079080
reactant: 079068
fast: false
reversible: true
name: v91 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4

079092
type: SpeciesReference
stoichiometry: 1.0
species: 326263

079080
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079068
type: SpeciesReference
stoichiometry: 1.0
species: 326261

329077
type: Parameter
constant: true
value: 0.03
name: kd34

327759
type: Reaction
kinetic law: 094021
product: 094009
reactant: 093997
reactant: 093985
fast: false
reversible: true
name: v416 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094009
type: SpeciesReference
stoichiometry: 1.0
species: 326104

093997
type: SpeciesReference
stoichiometry: 1.0
species: 326575

093985
type: SpeciesReference
stoichiometry: 1.0
species: 326503

327149
type: Reaction
kinetic law: 079828
product: 079816
reactant: 079804
reactant: 079792
fast: false
reversible: true
name: v106 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b

079816
type: SpeciesReference
stoichiometry: 1.0
species: 326295

079804
type: SpeciesReference
stoichiometry: 1.0
species: 326317

079792
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328279
type: Reaction
kinetic law: 105557
product: 105545
reactant: 105533
reactant: 105521
fast: false
reversible: true
name: v681 ErbB2#P + ErbB4#P -> (ErbB4:ErbB2)#P k103 kd103

105545
type: SpeciesReference
stoichiometry: 1.0
species: 325922

105533
type: SpeciesReference
stoichiometry: 1.0
species: 326781

105521
type: SpeciesReference
stoichiometry: 1.0
species: 326771

328017
type: Reaction
kinetic law: 099944
product: 099932
reactant: 099920
fast: false
reversible: true
name: v546 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

099932
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099920
type: SpeciesReference
stoichiometry: 1.0
species: 326393

329303
type: Parameter
notes: %PIP2 dissociates from PTEN
constant: true
value: 0.2
name: kd104

327373
type: Reaction
kinetic law: 084842
product: 084830
reactant: 084818
reactant: 084806
fast: false
reversible: true
name: v223 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

084830
type: SpeciesReference
stoichiometry: 1.0
species: 326088

084818
type: SpeciesReference
stoichiometry: 1.0
species: 326527

084806
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328323
type: Reaction
kinetic law: 106618
product: 106606
reactant: 106594
reactant: 106582
fast: false
reversible: true
name: v703 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k106 kd106

106606
type: SpeciesReference
stoichiometry: 1.0
species: 326723

106594
type: SpeciesReference
stoichiometry: 1.0
species: 326721

106582
type: SpeciesReference
stoichiometry: 1.0
species: 326793

327683
type: Reaction
kinetic law: 092359
product: 092346
reactant: 092334
reactant: 092322
fast: false
reversible: true
name: v378 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b

092346
type: SpeciesReference
stoichiometry: 1.0
species: 326443

092334
type: SpeciesReference
stoichiometry: 1.0
species: 326511

092322
type: SpeciesReference
stoichiometry: 1.0
species: 326551

W3 CDTF: Thu Sep 08 12:47:19 BST 2011

327421
type: Reaction
kinetic law: 086002
product: 085990
reactant: 085978
reactant: 085966
fast: false
reversible: true
name: v247 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17

085990
type: SpeciesReference
stoichiometry: 1.0
species: 326421

085978
type: SpeciesReference
stoichiometry: 1.0
species: 326419

085966
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328583
type: Reaction
kinetic law: 112891
product: 112879
reactant: 112867
reactant: 112855
fast: false
reversible: true
name: v854 EGF:ErbB1_h:Inh + EGF:ErbB1:Inh -> EGF:ErbB1_h:Inh::EGF:ErbB1:Inh k2 kd2

112879
type: SpeciesReference
stoichiometry: 1.0
species: 326937

326937
type: Species
notes: (EGF:ErbB1:Inh::EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:Inh::EGF:ErbB1_h:Inh)

112867
type: SpeciesReference
stoichiometry: 1.0
species: 325926

112855
type: SpeciesReference
stoichiometry: 1.0
species: 326913

328047
type: Reaction
kinetic law: 100485
product: 100473
reactant: 100461
fast: false
reversible: true
name: v563 (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60

100473
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100461
type: SpeciesReference
stoichiometry: 1.0
species: 326363

329015
type: Parameter
constant: true
value: 1.667E-8
name: k15

328981
type: Parameter
constant: true
value: 0.80833
name: kd5

328251
type: Reaction
kinetic law: 104881
product: 104869
reactant: 104857
reactant: 104845
fast: false
reversible: true
name: v667 ErbB4 + Inh -> ErbB4:Inh k99 kd99

104869
type: SpeciesReference
stoichiometry: 1.0
species: 325972

104857
type: SpeciesReference
stoichiometry: 1.0
species: 326775

104845
type: SpeciesReference
stoichiometry: 1.0
species: 325946

329155
type: Parameter
constant: true
value: 1.07E-5
name: k44

326973
type: Reaction
kinetic law: 075558
product: 075545
reactant: 075532
reactant: 075519
fast: false
reversible: true
name: v14 EGF:ErbB1:ATP + ErbB4 -> (EGF:ErbB1:ErbB4) k2b kd2b

075545
type: SpeciesReference
stoichiometry: 1.0
species: 325960

075532
type: SpeciesReference
stoichiometry: 1.0
species: 325958

075519
type: SpeciesReference
stoichiometry: 1.0
species: 325934

329223
type: Parameter
constant: true
value: 3.5E-5
name: k22b

328035
type: Reaction
kinetic law: 100268
product: 100256
reactant: 100244
fast: false
reversible: true
name: v555 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

100256
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100244
type: SpeciesReference
stoichiometry: 1.0
species: 326375

327545
type: Reaction
kinetic law: 088988
product: 088976
reactant: 088964
reactant: 088952
fast: false
reversible: true
name: v309 Ras:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088976
type: SpeciesReference
stoichiometry: 1.0
species: 326261

088964
type: SpeciesReference
stoichiometry: 1.0
species: 326253

088952
type: SpeciesReference
stoichiometry: 1.0
species: 326543

329193
type: Parameter
constant: true
value: 6.67E-7
name: k70

327225
type: Reaction
kinetic law: 081659
product: 081647
reactant: 081635
reactant: 081623
fast: false
reversible: true
name: v147 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b

081647
type: SpeciesReference
stoichiometry: 1.0
species: 326114

081635
type: SpeciesReference
stoichiometry: 1.0
species: 326393

081623
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329087
type: Parameter
constant: true
value: 0.0
name: kd36

327503
type: Reaction
kinetic law: 087974
product: 087962
reactant: 087950
reactant: 087938
fast: false
reversible: true
name: v288 (Ras:GTP)_i + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

087962
type: SpeciesReference
stoichiometry: 1.0
species: 326345

087950
type: SpeciesReference
stoichiometry: 1.0
species: 326347

087938
type: SpeciesReference
stoichiometry: 1.0
species: 326545

327851
type: Reaction
kinetic law: 096222
product: 096210
reactant: 096198
reactant: 096186
fast: false
reversible: true
name: v462 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37

096210
type: SpeciesReference
stoichiometry: 1.0
species: 326213

096198
type: SpeciesReference
stoichiometry: 1.0
species: 326525

096186
type: SpeciesReference
stoichiometry: 1.0
species: 326481

327091
type: Reaction
kinetic law: 078430
product: 078418
reactant: 078406
reactant: 078394
fast: false
reversible: true
name: v76 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k4b kd4

078418
type: SpeciesReference
stoichiometry: 1.0
species: 326207

078406
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078394
type: SpeciesReference
stoichiometry: 1.0
species: 326205

328435
type: Reaction
kinetic law: 109315
product: 109303
reactant: 109291
reactant: 109279
fast: false
reversible: true
name: v759 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113

109303
type: SpeciesReference
stoichiometry: 1.0
species: 326865

109291
type: SpeciesReference
stoichiometry: 1.0
species: 326689

109279
type: SpeciesReference
stoichiometry: 1.0
species: 326543

327795
type: Reaction
kinetic law: 094887
product: 094875
reactant: 094863
reactant: 094851
fast: false
reversible: true
name: v434 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34

094875
type: SpeciesReference
stoichiometry: 1.0
species: 326361

094863
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094851
type: SpeciesReference
stoichiometry: 1.0
species: 326497

327903
type: Reaction
kinetic law: 097477
product: 097465
reactant: 097453
reactant: 097441
fast: false
reversible: true
name: v488 Pase1 + Raf#P -> Raf#P:Pase1 k42 kd42

097465
type: SpeciesReference
stoichiometry: 1.0
species: 326583

097453
type: SpeciesReference
stoichiometry: 1.0
species: 326573

097441
type: SpeciesReference
stoichiometry: 1.0
species: 326579

327199
type: Reaction
kinetic law: 081029
product: 081017
reactant: 081005
reactant: 080993
fast: false
reversible: true
name: v134 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b

081017
type: SpeciesReference
stoichiometry: 1.0
species: 326195

081005
type: SpeciesReference
stoichiometry: 1.0
species: 326367

080993
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328103
type: Reaction
kinetic law: 101494
product: 101482
reactant: 101470
fast: false
reversible: true
name: v593 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60

101482
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101470
type: SpeciesReference
stoichiometry: 1.0
species: 326335

326991
type: Reaction
kinetic law: 076019
product: 076007
reactant: 075995
reactant: 075983
fast: false
reversible: true
name: v23 (EGF:ErbB1:ErbB4) + ATP -> (EGF:ErbB1:ErbB4):ATP k122 kd122

076007
type: SpeciesReference
stoichiometry: 1.0
species: 325986

075995
type: SpeciesReference
stoichiometry: 1.0
species: 325980

075983
type: SpeciesReference
stoichiometry: 1.0
species: 325960

327019
type: Reaction
kinetic law: 076693
product: 076681
reactant: 076669
reactant: 076657
fast: false
reversible: true
name: v37 (HRG:ErbB3:ErbB1) + ATP -> (HRG:ErbB3:ErbB1):ATP k122 kd122

076681
type: SpeciesReference
stoichiometry: 1.0
species: 326032

076669
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076657
type: SpeciesReference
stoichiometry: 1.0
species: 326030

328095
type: Reaction
kinetic law: 101350
product: 101338
reactant: 101326
fast: false
reversible: true
name: v589 (ErbB4:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60

101338
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101326
type: SpeciesReference
stoichiometry: 1.0
species: 326323

327659
type: Reaction
kinetic law: 091782
product: 091770
reactant: 091758
reactant: 091746
fast: false
reversible: true
name: v366 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091770
type: SpeciesReference
stoichiometry: 1.0
species: 326311

091758
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091746
type: SpeciesReference
stoichiometry: 1.0
species: 326319

327049
type: Reaction
kinetic law: 077417
product: 077405
reactant: 077393
reactant: 077381
fast: false
reversible: true
name: v53 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k4b kd4

077405
type: SpeciesReference
stoichiometry: 1.0
species: 326094

077393
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077381
type: SpeciesReference
stoichiometry: 1.0
species: 326092

328995
type: Parameter
constant: true
value: 0.2
name: kd8

327703
type: Reaction
kinetic law: 092745
product: 092733
reactant: 092721
fast: false
reversible: true
name: v388 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23

092733
type: SpeciesReference
stoichiometry: 1.0
species: 326437

092721
type: SpeciesReference
stoichiometry: 1.0
species: 326433

328223
type: Reaction
kinetic law: 104204
product: 104192
reactant: 104180
reactant: 104168
fast: false
reversible: true
name: v653 RTK_Pase + 2(ErbB2)#P -> 2(ErbB2)#P:RTK_Pase k94 kd94

104192
type: SpeciesReference
stoichiometry: 1.0
species: 326763

104180
type: SpeciesReference
stoichiometry: 1.0
species: 326475

104168
type: SpeciesReference
stoichiometry: 1.0
species: 326755

326949
type: Reaction
kinetic law: 074976
product: 074964
reactant: 074951
reactant: 074939
fast: false
reversible: true
name: v2 (ErbB2:ErbB3) + EGF -> (ErbB3:ErbB2)#P k1c kd1c

074964
type: SpeciesReference
stoichiometry: 1.0
species: 325918

074951
type: SpeciesReference
stoichiometry: 1.0
species: 325910

074939
type: SpeciesReference
stoichiometry: 1.0
species: 325916

327963
type: Reaction
kinetic law: 098921
product: 098909
reactant: 098897
reactant: 098885
fast: false
reversible: true
name: v518 ERK#P + Pase3 -> ERK#P#P:Pase3 k57 kd57

098909
type: SpeciesReference
stoichiometry: 1.0
species: 326633

098897
type: SpeciesReference
stoichiometry: 1.0
species: 326631

098885
type: SpeciesReference
stoichiometry: 1.0
species: 326617

329263
type: Parameter
constant: false
value: 0.015
name: kd97

328483
type: Reaction
kinetic law: 110460
product: 110448
reactant: 110436
reactant: 110423
fast: false
reversible: true
name: v783 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k118 kd118

110448
type: SpeciesReference
stoichiometry: 1.0
species: 326899

110436
type: SpeciesReference
stoichiometry: 1.0
species: 326703

110423
type: SpeciesReference
stoichiometry: 1.0
species: 326885

327551
type: Reaction
kinetic law: 089132
product: 089120
reactant: 089108
reactant: 089096
fast: false
reversible: true
name: v312 (Ras_activated:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089120
type: SpeciesReference
stoichiometry: 1.0
species: 326329

089108
type: SpeciesReference
stoichiometry: 1.0
species: 326337

089096
type: SpeciesReference
stoichiometry: 1.0
species: 326549

327363
type: Reaction
kinetic law: 084601
product: 084589
reactant: 084577
reactant: 084565
fast: false
reversible: true
name: v218 Grb2 + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24

084589
type: SpeciesReference
stoichiometry: 1.0
species: 326140

084577
type: SpeciesReference
stoichiometry: 1.0
species: 326503

084565
type: SpeciesReference
stoichiometry: 1.0
species: 326521

327021
type: Reaction
kinetic law: 076741
product: 076729
reactant: 076717
reactant: 076705
fast: false
reversible: true
name: v38 (HRG:ErbB4:ErbB1) + ATP -> (HRG:ErbB4:ErbB1):ATP k122 kd122

076729
type: SpeciesReference
stoichiometry: 1.0
species: 326036

076717
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076705
type: SpeciesReference
stoichiometry: 1.0
species: 326034

328317
type: Reaction
kinetic law: 106474
product: 106461
reactant: 106449
reactant: 106437
fast: false
reversible: true
name: v700 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106

106461
type: SpeciesReference
stoichiometry: 1.0
species: 326709

106449
type: SpeciesReference
stoichiometry: 1.0
species: 326701

106437
type: SpeciesReference
stoichiometry: 1.0
species: 326793

328151
type: Reaction
kinetic law: 102470
product: 102458
reactant: 102446
reactant: 102434
fast: false
reversible: true
name: v617 ERK#P#P + Sos#P -> (ERK#P#P):Sos k65 kd65

102458
type: SpeciesReference
stoichiometry: 1.0
species: 326663

102446
type: SpeciesReference
stoichiometry: 1.0
species: 326671

102434
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327827
type: Reaction
kinetic law: 095645
product: 095633
reactant: 095621
reactant: 095609
fast: false
reversible: true
name: v450 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37

095633
type: SpeciesReference
stoichiometry: 1.0
species: 326531

095621
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095609
type: SpeciesReference
stoichiometry: 1.0
species: 326505

327067
type: Reaction
kinetic law: 077853
product: 077840
reactant: 077828
reactant: 077816
fast: false
reversible: true
name: v62 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4

077840
type: SpeciesReference
stoichiometry: 1.0
species: 326130

077828
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077816
type: SpeciesReference
stoichiometry: 1.0
species: 326128

329327
type: Parameter
constant: true
value: 0.1
name: kd109

327415
type: Reaction
kinetic law: 085856
product: 085844
reactant: 085832
reactant: 085820
fast: false
reversible: true
name: v244 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17

085844
type: SpeciesReference
stoichiometry: 1.0
species: 326319

085832
type: SpeciesReference
stoichiometry: 1.0
species: 326323

085820
type: SpeciesReference
stoichiometry: 1.0
species: 326539

327509
type: Reaction
kinetic law: 088118
product: 088106
reactant: 088094
reactant: 088082
fast: false
reversible: true
name: v291 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088106
type: SpeciesReference
stoichiometry: 1.0
species: 326409

088094
type: SpeciesReference
stoichiometry: 1.0
species: 326545

088082
type: SpeciesReference
stoichiometry: 1.0
species: 326411

328573
type: Reaction
kinetic law: 112650
product: 112638
reactant: 112626
reactant: 112613
fast: false
reversible: true
name: v829 ErbB1_h + ATP -> ErbB1_h:ATP k122 kd122

112638
type: SpeciesReference
stoichiometry: 1.0
species: 326919

112626
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112613
type: SpeciesReference
stoichiometry: 1.0
species: 326909

328347
type: Reaction
kinetic law: 107195
product: 107183
reactant: 107171
reactant: 107159
fast: false
reversible: true
name: v715 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108

107183
type: SpeciesReference
stoichiometry: 1.0
species: 326809

107171
type: SpeciesReference
stoichiometry: 1.0
species: 326006

107159
type: SpeciesReference
stoichiometry: 1.0
species: 326805

329183
type: Parameter
notes: %PIP3 dissociates from PI3K
constant: true
value: 0.2
name: kd68

327445
type: Reaction
kinetic law: 086581
product: 086569
reactant: 086556
reactant: 086544
fast: false
reversible: true
name: v259 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086569
type: SpeciesReference
stoichiometry: 1.0
species: 326112

086556
type: SpeciesReference
stoichiometry: 1.0
species: 326100

086544
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327111
type: Reaction
kinetic law: 078911
product: 078899
reactant: 078887
reactant: 078875
fast: false
reversible: true
name: v87 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4

078899
type: SpeciesReference
stoichiometry: 1.0
species: 326247

078887
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078875
type: SpeciesReference
stoichiometry: 1.0
species: 326245

326967
type: Reaction
kinetic law: 075411
product: 075399
reactant: 075386
reactant: 075374
fast: false
reversible: true
name: v11 ErbB4 + EGF:ErbB1:ATP -> EGF:ErbB1:ErbB4 k2b kd2b

075399
type: SpeciesReference
stoichiometry: 1.0
species: 325948

075386
type: SpeciesReference
stoichiometry: 1.0
species: 325914

075374
type: SpeciesReference
stoichiometry: 1.0
species: 325946

329285
type: Parameter
constant: true
value: 0.001
name: kd100

328275
type: Reaction
kinetic law: 105461
product: 105449
reactant: 105437
reactant: 105425
fast: false
reversible: true
name: v679 ErbB2 + ErbB4 -> ErbB2:ErbB4 k103 kd103

105449
type: SpeciesReference
stoichiometry: 1.0
species: 325920

105437
type: SpeciesReference
stoichiometry: 1.0
species: 325946

105425
type: SpeciesReference
stoichiometry: 1.0
species: 325938

327249
type: Reaction
kinetic law: 082237
product: 082225
reactant: 082213
reactant: 082201
fast: false
reversible: true
name: v160 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5

082225
type: SpeciesReference
stoichiometry: 1.0
species: 326066

082213
type: SpeciesReference
stoichiometry: 1.0
species: 326417

082201
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327475
type: Reaction
kinetic law: 087301
product: 087289
reactant: 087277
reactant: 087265
fast: false
reversible: true
name: v274 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087289
type: SpeciesReference
stoichiometry: 1.0
species: 326345

087277
type: SpeciesReference
stoichiometry: 1.0
species: 326347

087265
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327615
type: Reaction
kinetic law: 090724
product: 090712
reactant: 090700
reactant: 090688
fast: false
reversible: true
name: v344 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

090712
type: SpeciesReference
stoichiometry: 1.0
species: 326415

090700
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090688
type: SpeciesReference
stoichiometry: 1.0
species: 326421

327005
type: Reaction
kinetic law: 076355
product: 076343
reactant: 076331
reactant: 076319
fast: false
reversible: true
name: v30 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122

076343
type: SpeciesReference
stoichiometry: 1.0
species: 326004

076331
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076319
type: SpeciesReference
stoichiometry: 1.0
species: 326002

329345
type: Parameter
notes: %AKT inhibiert Raf
constant: true
value: 4.98816E-6
name: k114

327789
type: Reaction
kinetic law: 094743
product: 094731
reactant: 094719
reactant: 094707
fast: false
reversible: true
name: v431 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34

094731
type: SpeciesReference
stoichiometry: 1.0
species: 326205

094719
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094707
type: SpeciesReference
stoichiometry: 1.0
species: 326503

327527
type: Reaction
kinetic law: 088553
product: 088541
reactant: 088529
reactant: 088517
fast: false
reversible: true
name: v300 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088541
type: SpeciesReference
stoichiometry: 1.0
species: 326389

088529
type: SpeciesReference
stoichiometry: 1.0
species: 326545

088517
type: SpeciesReference
stoichiometry: 1.0
species: 326395

327875
type: Reaction
kinetic law: 096800
product: 096788
reactant: 096776
reactant: 096764
fast: false
reversible: true
name: v474 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

096788
type: SpeciesReference
stoichiometry: 1.0
species: 326411

096776
type: SpeciesReference
stoichiometry: 1.0
species: 326439

096764
type: SpeciesReference
stoichiometry: 1.0
species: 326577

329375
type: Parameter
constant: false
value: 0.1
name: kd120b

328459
type: Reaction
kinetic law: 109879
product: 109867
reactant: 109855
reactant: 109843
fast: false
reversible: true
name: v771 Pase9t + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)2:Gab1#P##:Pase9t k117 kd117

109867
type: SpeciesReference
stoichiometry: 1.0
species: 326889

109855
type: SpeciesReference
stoichiometry: 1.0
species: 326851

109843
type: SpeciesReference
stoichiometry: 1.0
species: 326885

327339
type: Reaction
kinetic law: 084035
product: 084023
reactant: 084011
reactant: 083998
fast: false
reversible: true
name: v205 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8

084023
type: SpeciesReference
stoichiometry: 1.0
species: 326513

084011
type: SpeciesReference
stoichiometry: 1.0
species: 326479

083998
type: SpeciesReference
stoichiometry: 1.0
species: 326493

327173
type: Reaction
kinetic law: 080404
product: 080392
reactant: 080380
reactant: 080368
fast: false
reversible: true
name: v118 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b

080392
type: SpeciesReference
stoichiometry: 1.0
species: 326247

080380
type: SpeciesReference
stoichiometry: 1.0
species: 326341

080368
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328947
type: Parameter
constant: false
units: metaid_0000007
value: 0.0
name: model_time

327927
type: Reaction
kinetic law: 098055
product: 098043
reactant: 098031
reactant: 098019
fast: false
reversible: true
name: v500 MEK#P#P + Pase2 -> MEK#P#P:Pase2 k48 kd48

098043
type: SpeciesReference
stoichiometry: 1.0
species: 326607

098031
type: SpeciesReference
stoichiometry: 1.0
species: 326603

098019
type: SpeciesReference
stoichiometry: 1.0
species: 326599

327275
type: Reaction
kinetic law: 082731
product: 082719
reactant: 082707
fast: false
reversible: true
name: v173 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k6 kd6

082719
type: SpeciesReference
stoichiometry: 1.0
species: 326409

082707
type: SpeciesReference
stoichiometry: 1.0
species: 326080

328353
type: Reaction
kinetic law: 107339
product: 107327
reactant: 107315
reactant: 107303
fast: false
reversible: true
name: v718 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108

107327
type: SpeciesReference
stoichiometry: 1.0
species: 326815

107315
type: SpeciesReference
stoichiometry: 1.0
species: 326018

107303
type: SpeciesReference
stoichiometry: 1.0
species: 326805

328127
type: Reaction
kinetic law: 101929
product: 101917
reactant: 101905
fast: false
reversible: true
name: v605 (HRG:ErbB3):ErbB2) -> R_degraded k62b kd60b

101917
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101905
type: SpeciesReference
stoichiometry: 1.0
species: 326046

328549
type: Reaction
kinetic law: 112040
product: 112027
reactant: 112014
reactant: 112001
fast: false
reversible: true
name: v817 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k123 kd123

112027
type: SpeciesReference
stoichiometry: 1.0
species: 326012

112014
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112001
type: SpeciesReference
stoichiometry: 1.0
species: 326683

328383
type: Reaction
kinetic law: 108062
product: 108050
reactant: 108038
reactant: 108026
fast: false
reversible: true
name: v733 ERK#P#P + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110

108050
type: SpeciesReference
stoichiometry: 1.0
species: 326841

108038
type: SpeciesReference
stoichiometry: 1.0
species: 326699

108026
type: SpeciesReference
stoichiometry: 1.0
species: 326627

329159
type: Parameter
constant: true
value: 0.0
name: kd60

327727
type: Reaction
kinetic law: 093248
product: 093236
reactant: 093224
reactant: 093212
fast: false
reversible: true
name: v400 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093236
type: SpeciesReference
stoichiometry: 1.0
species: 326399

093224
type: SpeciesReference
stoichiometry: 1.0
species: 326405

093212
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328247
type: Reaction
kinetic law: 104785
product: 104773
reactant: 104761
reactant: 104749
fast: false
reversible: true
name: v665 ErbB1 + Inh -> ErbB1:Inh k97 kd97

104773
type: SpeciesReference
stoichiometry: 1.0
species: 325924

104761
type: SpeciesReference
stoichiometry: 1.0
species: 326775

104749
type: SpeciesReference
stoichiometry: 1.0
species: 326773

327117
type: Reaction
kinetic law: 079056
product: 079044
reactant: 079031
reactant: 079019
fast: false
reversible: true
name: v90 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4

079044
type: SpeciesReference
stoichiometry: 1.0
species: 326259

079031
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079019
type: SpeciesReference
stoichiometry: 1.0
species: 326257

327401
type: Reaction
kinetic law: 085518
product: 085506
reactant: 085494
reactant: 085482
fast: false
reversible: true
name: v237 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd63

085506
type: SpeciesReference
stoichiometry: 1.0
species: 326273

085494
type: SpeciesReference
stoichiometry: 1.0
species: 326521

085482
type: SpeciesReference
stoichiometry: 1.0
species: 326507

329393
type: Parameter
notes: KDATP=1e-4
constant: false
value: 1.8704E-8
name: k122

327575
type: Reaction
kinetic law: 089743
product: 089730
reactant: 089717
reactant: 089704
fast: false
reversible: true
name: v324 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089730
type: SpeciesReference
stoichiometry: 1.0
species: 326407

089717
type: SpeciesReference
stoichiometry: 1.0
species: 326411

089704
type: SpeciesReference
stoichiometry: 1.0
species: 326549

327191
type: Reaction
kinetic law: 080836
product: 080824
reactant: 080812
reactant: 080800
fast: false
reversible: true
name: v128 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k5 kd5b

080824
type: SpeciesReference
stoichiometry: 1.0
species: 326211

080812
type: SpeciesReference
stoichiometry: 1.0
species: 326359

080800
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328187
type: Reaction
kinetic law: 103339
product: 103327
reactant: 103315
reactant: 103303
fast: false
reversible: true
name: v635 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k68 kd68b

103327
type: SpeciesReference
stoichiometry: 1.0
species: 326723

103315
type: SpeciesReference
stoichiometry: 1.0
species: 326721

103303
type: SpeciesReference
stoichiometry: 1.0
species: 326707

329249
type: Parameter
constant: true
value: 1.38E-4
name: kd7

327387
type: Reaction
kinetic law: 085181
product: 085169
reactant: 085157
reactant: 085145
fast: false
reversible: true
name: v230 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

085169
type: SpeciesReference
stoichiometry: 1.0
species: 326357

085157
type: SpeciesReference
stoichiometry: 1.0
species: 326491

085145
type: SpeciesReference
stoichiometry: 1.0
species: 326521

327651
type: Reaction
kinetic law: 091589
product: 091577
reactant: 091565
reactant: 091552
fast: false
reversible: true
name: v362 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

091577
type: SpeciesReference
stoichiometry: 1.0
species: 326329

091565
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091552
type: SpeciesReference
stoichiometry: 1.0
species: 326337

327439
type: Reaction
kinetic law: 086435
product: 086423
reactant: 086411
reactant: 086399
fast: false
reversible: true
name: v256 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086423
type: SpeciesReference
stoichiometry: 1.0
species: 326080

086411
type: SpeciesReference
stoichiometry: 1.0
species: 326076

086399
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327205
type: Reaction
kinetic law: 081173
product: 081161
reactant: 081149
reactant: 081137
fast: false
reversible: true
name: v137 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b

081161
type: SpeciesReference
stoichiometry: 1.0
species: 326154

081149
type: SpeciesReference
stoichiometry: 1.0
species: 326373

081137
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328597
type: Reaction
kinetic law: 113227
product: 113215
reactant: 113203
reactant: 113191
fast: false
reversible: true
name: v861 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k123 kd123

113215
type: SpeciesReference
stoichiometry: 1.0
species: 326943

113203
type: SpeciesReference
stoichiometry: 1.0
species: 325980

113191
type: SpeciesReference
stoichiometry: 1.0
species: 326425

327745
type: Reaction
kinetic law: 093681
product: 093669
reactant: 093657
reactant: 093644
fast: false
reversible: true
name: v409 Ras:GTP + Raf -> Raf:Ras:GTP k28 kd28

093669
type: SpeciesReference
stoichiometry: 1.0
species: 326567

093657
type: SpeciesReference
stoichiometry: 1.0
species: 326565

093644
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328415
type: Reaction
kinetic law: 108832
product: 108820
reactant: 108808
reactant: 108796
fast: false
reversible: true
name: v749 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111

108820
type: SpeciesReference
stoichiometry: 1.0
species: 326845

108808
type: SpeciesReference
stoichiometry: 1.0
species: 326861

108796
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327135
type: Reaction
kinetic law: 079491
product: 079479
reactant: 079467
reactant: 079455
fast: false
reversible: true
name: v99 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4

079479
type: SpeciesReference
stoichiometry: 1.0
species: 326295

079467
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079455
type: SpeciesReference
stoichiometry: 1.0
species: 326293

328265
type: Reaction
kinetic law: 105219
product: 105207
reactant: 105195
reactant: 105183
fast: false
reversible: true
name: v674 ErbB2#P + EGF:ErbB1#P -> (ErbB1:ErbB2)#P k102 kd102

105207
type: SpeciesReference
stoichiometry: 1.0
species: 326461

105195
type: SpeciesReference
stoichiometry: 1.0
species: 326777

105183
type: SpeciesReference
stoichiometry: 1.0
species: 326771

328003
type: Reaction
kinetic law: 099692
product: 099680
reactant: 099668
fast: false
reversible: true
name: v539 ErbB4 -> R_degraded k60b kd60b

099680
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099668
type: SpeciesReference
stoichiometry: 1.0
species: 325958

329331
type: Parameter
constant: true
value: 0.1
name: kd110

329169
type: Parameter
constant: true
value: 0.3
name: kd64

327775
type: Reaction
kinetic law: 094405
product: 094393
reactant: 094381
reactant: 094369
fast: false
reversible: true
name: v424 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094393
type: SpeciesReference
stoichiometry: 1.0
species: 326325

094381
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094369
type: SpeciesReference
stoichiometry: 1.0
species: 326511

328359
type: Reaction
kinetic law: 107484
product: 107472
reactant: 107459
reactant: 107447
fast: false
reversible: true
name: v721 PIP3 + PTEN -> PIP3:PTEN k109 kd109

107472
type: SpeciesReference
stoichiometry: 1.0
species: 326799

107459
type: SpeciesReference
stoichiometry: 1.0
species: 326797

107447
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327513
type: Reaction
kinetic law: 088215
product: 088203
reactant: 088191
reactant: 088179
fast: false
reversible: true
name: v293 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088203
type: SpeciesReference
stoichiometry: 1.0
species: 326080

088191
type: SpeciesReference
stoichiometry: 1.0
species: 326543

088179
type: SpeciesReference
stoichiometry: 1.0
species: 326076

327239
type: Reaction
kinetic law: 081997
product: 081985
reactant: 081973
reactant: 081961
fast: false
reversible: true
name: v155 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5

081985
type: SpeciesReference
stoichiometry: 1.0
species: 326086

081973
type: SpeciesReference
stoichiometry: 1.0
species: 326309

081961
type: SpeciesReference
stoichiometry: 1.0
species: 326407

327499
type: Reaction
kinetic law: 087878
product: 087866
reactant: 087854
reactant: 087842
fast: false
reversible: true
name: v286 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

087866
type: SpeciesReference
stoichiometry: 1.0
species: 326315

087854
type: SpeciesReference
stoichiometry: 1.0
species: 326319

087842
type: SpeciesReference
stoichiometry: 1.0
species: 326545

329043
type: Parameter
constant: true
value: 1.39338E-7
name: k22

329369
type: Parameter
notes: %dimerization
constant: false
value: 1.48131E-8
name: k120

328449
type: Reaction
kinetic law: 109651
product: 109639
reactant: 109627
reactant: 109615
fast: false
reversible: true
name: v766 AKT#P#P + (Raf#P)_i -> AKT:P:P:Raf:P:Ser_i k114 kd114

109639
type: SpeciesReference
stoichiometry: 1.0
species: 326879

109627
type: SpeciesReference
stoichiometry: 1.0
species: 326571

109615
type: SpeciesReference
stoichiometry: 1.0
species: 326747

327167
type: Reaction
kinetic law: 080260
product: 080248
reactant: 080236
reactant: 080224
fast: false
reversible: true
name: v115 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b

080248
type: SpeciesReference
stoichiometry: 1.0
species: 326259

080236
type: SpeciesReference
stoichiometry: 1.0
species: 326335

080224
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328063
type: Reaction
kinetic law: 100772
product: 100760
reactant: 100748
fast: false
reversible: true
name: v572 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60

100760
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100748
type: SpeciesReference
stoichiometry: 1.0
species: 326353

327197
type: Reaction
kinetic law: 080981
product: 080969
reactant: 080957
reactant: 080945
fast: false
reversible: true
name: v133 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b

080969
type: SpeciesReference
stoichiometry: 1.0
species: 326199

080957
type: SpeciesReference
stoichiometry: 1.0
species: 326365

080945
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329103
type: Parameter
constant: true
value: 0.0141589
name: kd42

328377
type: Reaction
kinetic law: 107918
product: 107906
reactant: 107894
reactant: 107882
fast: false
reversible: true
name: v730 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110

107906
type: SpeciesReference
stoichiometry: 1.0
species: 326835

107894
type: SpeciesReference
stoichiometry: 1.0
species: 326683

107882
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328203
type: Reaction
kinetic law: 103724
product: 103712
reactant: 103700
reactant: 103688
fast: false
reversible: true
name: v643 PIP3:PDK1 + AKT#P -> PIP3:AKT:PDK1 k71 kd71

103712
type: SpeciesReference
stoichiometry: 1.0
species: 326743

103700
type: SpeciesReference
stoichiometry: 1.0
species: 326735

103688
type: SpeciesReference
stoichiometry: 1.0
species: 326745

327531
type: Reaction
kinetic law: 088650
product: 088638
reactant: 088626
reactant: 088614
fast: false
reversible: true
name: v302 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19

088638
type: SpeciesReference
stoichiometry: 1.0
species: 326152

088626
type: SpeciesReference
stoichiometry: 1.0
species: 326205

088614
type: SpeciesReference
stoichiometry: 1.0
species: 326543

328963
type: Parameter
constant: true
value: 3.73632E-8
name: k2b

329133
type: Parameter
constant: true
value: 0.28
name: kd53

329073
type: Parameter
constant: true
value: 0.2
name: kd33

329205
type: Parameter
notes: %Pase4 binds AKT:P:P
constant: false
value: 0.00374845
name: k73

327287
type: Reaction
kinetic law: 082949
product: 082936
reactant: 082924
fast: false
reversible: true
name: v179 (ErbB3:ErbB2)#P:GAP:Shc ->(ErbB3:ErbB2)#P:GAP:Shc k6b kd6b

082936
type: SpeciesReference
stoichiometry: 1.0
species: 326443

082924
type: SpeciesReference
stoichiometry: 1.0
species: 326441

328131
type: Reaction
kinetic law: 102001
product: 101989
reactant: 101977
fast: false
reversible: true
name: v607 (ErbB3:ErbB2) -> R_degraded k62b kd60b

101989
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101977
type: SpeciesReference
stoichiometry: 1.0
species: 326651

327781
type: Reaction
kinetic law: 094549
product: 094537
reactant: 094525
reactant: 094513
fast: false
reversible: true
name: v427 (Shc#P) + Grb2:Sos -> (Shc#P):Grb2:Sos k33 kd33

094537
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094525
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094513
type: SpeciesReference
stoichiometry: 1.0
species: 326523

327977
type: Reaction
kinetic law: 099224
product: 099212
reactant: 099200
fast: false
reversible: true
name: v525 2(EGF:ErbB1)#P:GAP -> R_degraded k60 kd60

099212
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099200
type: SpeciesReference
stoichiometry: 1.0
species: 326431

329277
type: Parameter
constant: true
value: 0.113
name: Kinh4

328497
type: Reaction
kinetic law: 110796
product: 110784
reactant: 110772
reactant: 110760
fast: false
reversible: true
name: v790 HRG:ErbB4 + ErbB1:ATP -> (HRG:ErbB4:ErbB1) k120b kd120

110784
type: SpeciesReference
stoichiometry: 1.0
species: 326034

110772
type: SpeciesReference
stoichiometry: 1.0
species: 325912

110760
type: SpeciesReference
stoichiometry: 1.0
species: 326905

327425
type: Reaction
kinetic law: 086099
product: 086087
reactant: 086075
reactant: 086063
fast: false
reversible: true
name: v249 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17

086087
type: SpeciesReference
stoichiometry: 1.0
species: 326201

086075
type: SpeciesReference
stoichiometry: 1.0
species: 326136

086063
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328177
type: Reaction
kinetic law: 103098
product: 103086
reactant: 103074
reactant: 103062
fast: false
reversible: true
name: v630 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K + PIP3 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68

103086
type: SpeciesReference
stoichiometry: 1.0
species: 326713

103074
type: SpeciesReference
stoichiometry: 1.0
species: 326707

103062
type: SpeciesReference
stoichiometry: 1.0
species: 326681

327331
type: Reaction
kinetic law: 083841
product: 083829
reactant: 083817
reactant: 083805
fast: false
reversible: true
name: v201 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b

083829
type: SpeciesReference
stoichiometry: 1.0
species: 326505

083817
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083805
type: SpeciesReference
stoichiometry: 1.0
species: 326469

327271
type: Reaction
kinetic law: 082659
product: 082647
reactant: 082635
fast: false
reversible: true
name: v171 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k6 kd6

082647
type: SpeciesReference
stoichiometry: 1.0
species: 326413

082635
type: SpeciesReference
stoichiometry: 1.0
species: 326072

328081
type: Reaction
kinetic law: 101097
product: 101085
reactant: 101073
fast: false
reversible: true
name: v582 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60

101085
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101073
type: SpeciesReference
stoichiometry: 1.0
species: 326459

329379
type: Parameter
constant: true
value: 0.001
name: k121

327591
type: Reaction
kinetic law: 090143
product: 090131
reactant: 090119
reactant: 090107
fast: false
reversible: true
name: v332 (Ras_activated:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

090131
type: SpeciesReference
stoichiometry: 1.0
species: 326351

090119
type: SpeciesReference
stoichiometry: 1.0
species: 326355

090107
type: SpeciesReference
stoichiometry: 1.0
species: 326549

327035
type: Reaction
kinetic law: 077079
product: 077067
reactant: 077055
reactant: 077043
fast: false
reversible: true
name: v45 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4 kd4

077067
type: SpeciesReference
stoichiometry: 1.0
species: 326066

077055
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077043
type: SpeciesReference
stoichiometry: 1.0
species: 326064

328229
type: Reaction
kinetic law: 104351
product: 104339
reactant: 104326
reactant: 104313
fast: false
reversible: true
name: v656 RTK_Pase + (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P:RTK_Pase k94 kd94

104339
type: SpeciesReference
stoichiometry: 1.0
species: 326769

104326
type: SpeciesReference
stoichiometry: 1.0
species: 326463

104313
type: SpeciesReference
stoichiometry: 1.0
species: 326755

327731
type: Reaction
kinetic law: 093344
product: 093332
reactant: 093320
reactant: 093308
fast: false
reversible: true
name: v402 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093332
type: SpeciesReference
stoichiometry: 1.0
species: 326395

093320
type: SpeciesReference
stoichiometry: 1.0
species: 326401

093308
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328541
type: Reaction
kinetic law: 111840
product: 111828
reactant: 111816
reactant: 111804
fast: false
reversible: true
name: v813 (ErbB1:ErbB4)#P + ATP -> EGF:ErbB1:ErbB4:ATP k123 kd123

111828
type: SpeciesReference
stoichiometry: 1.0
species: 325996

111816
type: SpeciesReference
stoichiometry: 1.0
species: 325980

111804
type: SpeciesReference
stoichiometry: 1.0
species: 326469

328315
type: Reaction
kinetic law: 106425
product: 106413
reactant: 106401
reactant: 106389
fast: false
reversible: true
name: v699 PIP2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106

106413
type: SpeciesReference
stoichiometry: 1.0
species: 326711

106401
type: SpeciesReference
stoichiometry: 1.0
species: 326697

106389
type: SpeciesReference
stoichiometry: 1.0
species: 326793

327675
type: Reaction
kinetic law: 092166
product: 092154
reactant: 092142
reactant: 092130
fast: false
reversible: true
name: v374 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b

092154
type: SpeciesReference
stoichiometry: 1.0
species: 326563

092142
type: SpeciesReference
stoichiometry: 1.0
species: 326499

092130
type: SpeciesReference
stoichiometry: 1.0
species: 326551

329113
type: Parameter
constant: true
value: 0.0
name: k45

329007
type: Parameter
constant: true
value: 0.0
name: k13

328405
type: Reaction
kinetic law: 108592
product: 108580
reactant: 108568
reactant: 108556
fast: false
reversible: true
name: v744 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111

108580
type: SpeciesReference
stoichiometry: 1.0
species: 326831

108568
type: SpeciesReference
stoichiometry: 1.0
species: 326855

108556
type: SpeciesReference
stoichiometry: 1.0
species: 326629

329299
type: Parameter
constant: false
value: 0.016
name: kd103

329215
type: Parameter
constant: true
value: 0.0
name: k75

328289
type: Reaction
kinetic law: 105798
product: 105786
reactant: 105774
reactant: 105762
fast: false
reversible: true
name: v686 Shp + PIP2 -> PIP3:Shp k104 kd104

105786
type: SpeciesReference
stoichiometry: 1.0
species: 326795

105774
type: SpeciesReference
stoichiometry: 1.0
species: 326793

105762
type: SpeciesReference
stoichiometry: 1.0
species: 326791

328027
type: Reaction
kinetic law: 100124
product: 100112
reactant: 100100
fast: false
reversible: true
name: v551 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60

100112
type: SpeciesReference
stoichiometry: 1.0
species: 326641

100100
type: SpeciesReference
stoichiometry: 1.0
species: 326383

327799
type: Reaction
kinetic law: 094985
product: 094973
reactant: 094960
reactant: 094948
fast: false
reversible: true
name: v436 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34

094973
type: SpeciesReference
stoichiometry: 1.0
species: 326233

094960
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094948
type: SpeciesReference
stoichiometry: 1.0
species: 326481

327153
type: Reaction
kinetic law: 079924
product: 079912
reactant: 079900
reactant: 079888
fast: false
reversible: true
name: v108 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b

079912
type: SpeciesReference
stoichiometry: 1.0
species: 326287

079900
type: SpeciesReference
stoichiometry: 1.0
species: 326321

079888
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329313
type: Parameter
constant: true
value: 2.63418E-8
name: k106b

328333
type: Reaction
kinetic law: 106858
product: 106846
reactant: 106834
reactant: 106822
fast: false
reversible: true
name: v708 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107

106846
type: SpeciesReference
stoichiometry: 1.0
species: 326809

106834
type: SpeciesReference
stoichiometry: 1.0
species: 326691

106822
type: SpeciesReference
stoichiometry: 1.0
species: 326805

327693
type: Reaction
kinetic law: 092564
product: 092551
reactant: 092539
fast: false
reversible: true
name: v383 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23

092551
type: SpeciesReference
stoichiometry: 1.0
species: 326457

092539
type: SpeciesReference
stoichiometry: 1.0
species: 326445

327083
type: Reaction
kinetic law: 078238
product: 078226
reactant: 078214
reactant: 078202
fast: false
reversible: true
name: v70 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4

078226
type: SpeciesReference
stoichiometry: 1.0
species: 326191

078214
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078202
type: SpeciesReference
stoichiometry: 1.0
species: 326189

327843
type: Reaction
kinetic law: 096030
product: 096018
reactant: 096006
reactant: 095994
fast: false
reversible: true
name: v458 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37

096018
type: SpeciesReference
stoichiometry: 1.0
species: 326403

096006
type: SpeciesReference
stoichiometry: 1.0
species: 326525

095994
type: SpeciesReference
stoichiometry: 1.0
species: 326497

328363
type: Reaction
kinetic law: 107581
product: 107568
reactant: 107556
reactant: 107544
fast: false
reversible: true
name: v723 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k110 kd110

107568
type: SpeciesReference
stoichiometry: 1.0
species: 326821

107556
type: SpeciesReference
stoichiometry: 1.0
species: 326679

107544
type: SpeciesReference
stoichiometry: 1.0
species: 326627

327431
type: Reaction
kinetic law: 086243
product: 086231
reactant: 086219
reactant: 086207
fast: false
reversible: true
name: v252 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17

086231
type: SpeciesReference
stoichiometry: 1.0
species: 326363

086219
type: SpeciesReference
stoichiometry: 1.0
species: 326381

086207
type: SpeciesReference
stoichiometry: 1.0
species: 326539

327889
type: Reaction
kinetic law: 097138
product: 097126
reactant: 097113
reactant: 097101
fast: false
reversible: true
name: v481 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

097126
type: SpeciesReference
stoichiometry: 1.0
species: 326217

097113
type: SpeciesReference
stoichiometry: 1.0
species: 326489

097101
type: SpeciesReference
stoichiometry: 1.0
species: 326577

327243
type: Reaction
kinetic law: 082093
product: 082081
reactant: 082069
reactant: 082057
fast: false
reversible: true
name: v157 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5

082081
type: SpeciesReference
stoichiometry: 1.0
species: 326078

082069
type: SpeciesReference
stoichiometry: 1.0
species: 326411

082057
type: SpeciesReference
stoichiometry: 1.0
species: 326309

329029
type: Parameter
constant: true
value: 1.3
name: kd18

328991
type: Parameter
constant: false
value: 5.0E-5
name: kd6

326983
type: Reaction
kinetic law: 075819
product: 075806
reactant: 075793
reactant: 075779
fast: false
reversible: true
name: v19 EGF:ErbB1:ATP + ErbB4:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b

075806
type: SpeciesReference
stoichiometry: 1.0
species: 325974

075793
type: SpeciesReference
stoichiometry: 1.0
species: 325972

075779
type: SpeciesReference
stoichiometry: 1.0
species: 325914

327707
type: Reaction
kinetic law: 092817
product: 092805
reactant: 092793
fast: false
reversible: true
name: v390 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23

092805
type: SpeciesReference
stoichiometry: 1.0
species: 326529

092793
type: SpeciesReference
stoichiometry: 1.0
species: 326555

329233
type: Parameter
constant: true
value: 5.0E-5
name: k94

328087
type: Reaction
kinetic law: 101205
product: 101193
reactant: 101181
fast: false
reversible: true
name: v585 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60

101193
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101181
type: SpeciesReference
stoichiometry: 1.0
species: 326339

328453
type: Reaction
kinetic law: 109747
product: 109735
reactant: 109723
reactant: 109711
fast: false
reversible: true
name: v768 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser_i k115 kd115

109735
type: SpeciesReference
stoichiometry: 1.0
species: 326879

109723
type: SpeciesReference
stoichiometry: 1.0
species: 326747

109711
type: SpeciesReference
stoichiometry: 1.0
species: 326881

327555
type: Reaction
kinetic law: 089229
product: 089217
reactant: 089204
reactant: 089192
fast: false
reversible: true
name: v314 (Ras_activated:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089217
type: SpeciesReference
stoichiometry: 1.0
species: 326331

089204
type: SpeciesReference
stoichiometry: 1.0
species: 326325

089192
type: SpeciesReference
stoichiometry: 1.0
species: 326549

328987
type: Parameter
constant: true
value: 0.162
name: kd5c

329097
type: Parameter
constant: true
value: 5.0E-5
name: k41

328505
type: Reaction
kinetic law: 110988
product: 110976
reactant: 110964
reactant: 110952
fast: false
reversible: true
name: v794 ErbB1_h + Inh -> ErbB1_h:Inh k97c kd97c

110976
type: SpeciesReference
stoichiometry: 1.0
species: 326911

110964
type: SpeciesReference
stoichiometry: 1.0
species: 326775

110952
type: SpeciesReference
stoichiometry: 1.0
species: 326909

329229
type: Parameter
constant: true
value: 7.5E-5
name: k34b

327631
type: Reaction
kinetic law: 091108
product: 091096
reactant: 091084
reactant: 091072
fast: false
reversible: true
name: v352 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

091096
type: SpeciesReference
stoichiometry: 1.0
species: 326383

091084
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091072
type: SpeciesReference
stoichiometry: 1.0
species: 326395

329199
type: Parameter
constant: true
value: 25.2
name: kd71

329323
type: Parameter
constant: true
value: 5.0
name: kd108

327355
type: Reaction
kinetic law: 084409
product: 084397
reactant: 084385
reactant: 084373
fast: false
reversible: true
name: v214 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24

084397
type: SpeciesReference
stoichiometry: 1.0
species: 326072

084385
type: SpeciesReference
stoichiometry: 1.0
species: 326437

084373
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328309
type: Reaction
kinetic law: 106280
product: 106268
reactant: 106256
reactant: 106244
fast: false
reversible: true
name: v696 PIP2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b

106268
type: SpeciesReference
stoichiometry: 1.0
species: 326715

106256
type: SpeciesReference
stoichiometry: 1.0
species: 326689

106244
type: SpeciesReference
stoichiometry: 1.0
species: 326793

327669
type: Reaction
kinetic law: 092022
product: 092010
reactant: 091998
reactant: 091986
fast: false
reversible: true
name: v371 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b

092010
type: SpeciesReference
stoichiometry: 1.0
species: 326557

091998
type: SpeciesReference
stoichiometry: 1.0
species: 326505

091986
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327059
type: Reaction
kinetic law: 077659
product: 077647
reactant: 077635
reactant: 077623
fast: false
reversible: true
name: v58 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4

077647
type: SpeciesReference
stoichiometry: 1.0
species: 326114

077635
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077623
type: SpeciesReference
stoichiometry: 1.0
species: 326112

327407
type: Reaction
kinetic law: 085663
product: 085651
reactant: 085639
reactant: 085627
fast: false
reversible: true
name: v240 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd63

085651
type: SpeciesReference
stoichiometry: 1.0
species: 326323

085639
type: SpeciesReference
stoichiometry: 1.0
species: 326521

085627
type: SpeciesReference
stoichiometry: 1.0
species: 326513

327981
type: Reaction
kinetic law: 099296
product: 099284
reactant: 099272
fast: false
reversible: true
name: v527 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> R_degraded k60 kd60

099284
type: SpeciesReference
stoichiometry: 1.0
species: 326641

099272
type: SpeciesReference
stoichiometry: 1.0
species: 326421

327755
type: Reaction
kinetic law: 093923
product: 093911
reactant: 093899
reactant: 093887
fast: false
reversible: true
name: v414 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

093911
type: SpeciesReference
stoichiometry: 1.0
species: 326411

093899
type: SpeciesReference
stoichiometry: 1.0
species: 326575

093887
type: SpeciesReference
stoichiometry: 1.0
species: 326431

328565
type: Reaction
kinetic law: 112454
product: 112442
reactant: 112429
reactant: 112416
fast: false
reversible: true
name: v825 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2:ATP k123 kd123

112442
type: SpeciesReference
stoichiometry: 1.0
species: 326044

112429
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112416
type: SpeciesReference
stoichiometry: 1.0
species: 325918

329281
type: Parameter
constant: false
value: 4.42
name: k99

328181
type: Reaction
kinetic law: 103194
product: 103182
reactant: 103170
reactant: 103158
fast: false
reversible: true
name: v632 PIP3 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68

103182
type: SpeciesReference
stoichiometry: 1.0
species: 326717

103170
type: SpeciesReference
stoichiometry: 1.0
species: 326693

103158
type: SpeciesReference
stoichiometry: 1.0
species: 326707

327699
type: Reaction
kinetic law: 092673
product: 092661
reactant: 092649
fast: false
reversible: true
name: v386 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23

092661
type: SpeciesReference
stoichiometry: 1.0
species: 326491

092649
type: SpeciesReference
stoichiometry: 1.0
species: 326487

327283
type: Reaction
kinetic law: 082876
product: 082864
reactant: 082852
fast: false
reversible: true
name: v177 ErbB2 -> ErbB2 k6b kd6b

082864
type: SpeciesReference
stoichiometry: 1.0
species: 325950

082852
type: SpeciesReference
stoichiometry: 1.0
species: 325938

327219
type: Reaction
kinetic law: 081513
product: 081500
reactant: 081488
reactant: 081476
fast: false
reversible: true
name: v144 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b

081500
type: SpeciesReference
stoichiometry: 1.0
species: 326126

081488
type: SpeciesReference
stoichiometry: 1.0
species: 326387

081476
type: SpeciesReference
stoichiometry: 1.0
species: 326309

328967
type: Parameter
constant: true
value: 1.0
name: k3

327807
type: Reaction
kinetic law: 095177
product: 095165
reactant: 095153
reactant: 095141
fast: false
reversible: true
name: v440 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34

095165
type: SpeciesReference
stoichiometry: 1.0
species: 326289

095153
type: SpeciesReference
stoichiometry: 1.0
species: 326577

095141
type: SpeciesReference
stoichiometry: 1.0
species: 326509

328233
type: Reaction
kinetic law: 104447
product: 104435
reactant: 104423
reactant: 104411
fast: false
reversible: true
name: v658 RTK_Pase + (EGF:ErbB1:ErbB3) -> (ErbB1:ErbB3)#P:RTK_Pase k95 kd95

104435
type: SpeciesReference
stoichiometry: 1.0
species: 326757

104423
type: SpeciesReference
stoichiometry: 1.0
species: 325956

104411
type: SpeciesReference
stoichiometry: 1.0
species: 326755

327713
type: Reaction
kinetic law: 092925
product: 092913
reactant: 092901
fast: false
reversible: true
name: v393 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23

092913
type: SpeciesReference
stoichiometry: 1.0
species: 326535

092901
type: SpeciesReference
stoichiometry: 1.0
species: 326561

329137
type: Parameter
constant: true
value: 70.1662
name: kd55

327103
type: Reaction
kinetic law: 078718
product: 078706
reactant: 078694
reactant: 078682
fast: false
reversible: true
name: v82 2(ErbB2)#P:GAP:Grb2 + cPP -> 2(ErbB2)#P:GAP:Grb2:cPP k4b kd4

078706
type: SpeciesReference
stoichiometry: 1.0
species: 326231

078694
type: SpeciesReference
stoichiometry: 1.0
species: 326056

078682
type: SpeciesReference
stoichiometry: 1.0
species: 326229

326959
type: Reaction
kinetic law: 075217
product: 075205
reactant: 075193
reactant: 075181
fast: false
reversible: true
name: v7 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP)) k2 kd2

075205
type: SpeciesReference
stoichiometry: 1.0
species: 325932

075193
type: SpeciesReference
stoichiometry: 1.0
species: 325914

075181
type: SpeciesReference
stoichiometry: 1.0
species: 325914

328493
type: Reaction
kinetic law: 110700
product: 110688
reactant: 110676
reactant: 110664
fast: false
reversible: true
name: v788 + HRG:ErbB4 -> k120 kd120

110688
type: SpeciesReference
stoichiometry: 1.0
species: 326038

110676
type: SpeciesReference
stoichiometry: 1.0
species: 326905

110664
type: SpeciesReference
stoichiometry: 1.0
species: 325938

328429
type: Reaction
kinetic law: 109170
product: 109158
reactant: 109146
reactant: 109134
fast: false
reversible: true
name: v756 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112

109158
type: SpeciesReference
stoichiometry: 1.0
species: 326873

109146
type: SpeciesReference
stoichiometry: 1.0
species: 326701

109134
type: SpeciesReference
stoichiometry: 1.0
species: 326541

329239
type: Parameter
constant: true
value: 33.0
name: kd95

327467
type: Reaction
kinetic law: 087109
product: 087097
reactant: 087085
reactant: 087073
fast: false
reversible: true
name: v270 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18

087097
type: SpeciesReference
stoichiometry: 1.0
species: 326371

087085
type: SpeciesReference
stoichiometry: 1.0
species: 326359

087073
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327833
type: Reaction
kinetic law: 095789
product: 095777
reactant: 095765
reactant: 095753
fast: false
reversible: true
name: v453 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37

095777
type: SpeciesReference
stoichiometry: 1.0
species: 326537

095765
type: SpeciesReference
stoichiometry: 1.0
species: 326523

095753
type: SpeciesReference
stoichiometry: 1.0
species: 326499

327607
type: Reaction
kinetic law: 090530
product: 090517
reactant: 090504
reactant: 090492
fast: false
reversible: true
name: v340 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

090517
type: SpeciesReference
stoichiometry: 1.0
species: 326343

090504
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090492
type: SpeciesReference
stoichiometry: 1.0
species: 326347

329057
type: Parameter
constant: true
value: 5.0E-6
name: k28

327519
type: Reaction
kinetic law: 088360
product: 088348
reactant: 088336
reactant: 088324
fast: false
reversible: true
name: v296 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19

088348
type: SpeciesReference
stoichiometry: 1.0
species: 326116

088336
type: SpeciesReference
stoichiometry: 1.0
species: 326543

088324
type: SpeciesReference
stoichiometry: 1.0
species: 326104

327455
type: Reaction
kinetic law: 086820
product: 086808
reactant: 086796
reactant: 086784
fast: false
reversible: true
name: v264 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18

086808
type: SpeciesReference
stoichiometry: 1.0
species: 326389

086796
type: SpeciesReference
stoichiometry: 1.0
species: 326395

086784
type: SpeciesReference
stoichiometry: 1.0
species: 326541

327761
type: Reaction
kinetic law: 094069
product: 094057
reactant: 094045
reactant: 094033
fast: false
reversible: true
name: v417 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32

094057
type: SpeciesReference
stoichiometry: 1.0
species: 326108

094045
type: SpeciesReference
stoichiometry: 1.0
species: 326575

094033
type: SpeciesReference
stoichiometry: 1.0
species: 326505

327267
type: Reaction
kinetic law: 082587
product: 082575
reactant: 082563
fast: false
reversible: true
name: v169 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k6 kd6

082575
type: SpeciesReference
stoichiometry: 1.0
species: 326421

082563
type: SpeciesReference
stoichiometry: 1.0
species: 326060

329295
type: Parameter
constant: true
value: 5.61009
name: kd102

328281
type: Reaction
kinetic law: 105605
product: 105593
reactant: 105581
reactant: 105569
fast: false
reversible: true
name: v682 ErbB2#P + ErbB2:Inh -> ErbB2:ErbB2:Inh k103 kd103

105593
type: SpeciesReference
stoichiometry: 1.0
species: 326783

326783
type: Species
notes: ErbB2:ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB2:ErbB2:Inh

105581
type: SpeciesReference
stoichiometry: 1.0
species: 325968

105569
type: SpeciesReference
stoichiometry: 1.0
species: 326771

327791
type: Reaction
kinetic law: 094791
product: 094779
reactant: 094767
reactant: 094755
fast: false
reversible: true
name: v432 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34

094779
type: SpeciesReference
stoichiometry: 1.0
species: 326209

094767
type: SpeciesReference
stoichiometry: 1.0
species: 326577

094755
type: SpeciesReference
stoichiometry: 1.0
species: 326505

327319
type: Reaction
kinetic law: 083552
product: 083540
reactant: 083528
reactant: 083516
fast: false
reversible: true
name: v195 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b

083540
type: SpeciesReference
stoichiometry: 1.0
species: 326497

083528
type: SpeciesReference
stoichiometry: 1.0
species: 326493

083516
type: SpeciesReference
stoichiometry: 1.0
species: 326467

328977
type: Parameter
constant: true
value: 1.66E-4
name: kd4b

328477
type: Reaction
kinetic law: 110315
product: 110303
reactant: 110291
reactant: 110279
fast: false
reversible: true
name: v780 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118

110303
type: SpeciesReference
stoichiometry: 1.0
species: 326893

110291
type: SpeciesReference
stoichiometry: 1.0
species: 326683

110279
type: SpeciesReference
stoichiometry: 1.0
species: 326885

327579
type: Reaction
kinetic law: 089847
product: 089834
reactant: 089821
reactant: 089808
fast: false
reversible: true
name: v326 Ras_activated:GTP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20

089834
type: SpeciesReference
stoichiometry: 1.0
species: 326128

089821
type: SpeciesReference
stoichiometry: 1.0
species: 326104

089808
type: SpeciesReference
stoichiometry: 1.0
species: 326547

329219
type: Parameter
constant: true
value: 142.262
name: kd76

327625
type: Reaction
kinetic law: 090964
product: 090952
reactant: 090940
reactant: 090928
fast: false
reversible: true
name: v349 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21

090952
type: SpeciesReference
stoichiometry: 1.0
species: 326132

090940
type: SpeciesReference
stoichiometry: 1.0
species: 326541

090928
type: SpeciesReference
stoichiometry: 1.0
species: 326108

327015
type: Reaction
kinetic law: 076595
product: 076583
reactant: 076571
reactant: 076559
fast: false
reversible: true
name: v35 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122

076583
type: SpeciesReference
stoichiometry: 1.0
species: 326024

076571
type: SpeciesReference
stoichiometry: 1.0
species: 325980

076559
type: SpeciesReference
stoichiometry: 1.0
species: 326022

328145
type: Reaction
kinetic law: 102326
product: 102314
reactant: 102302
reactant: 102290
fast: false
reversible: true
name: v614 (ERK#P#P)_i + Sos -> ((ERK#P#P):Sos)_i k64 kd64

102314
type: SpeciesReference
stoichiometry: 1.0
species: 326665

102302
type: SpeciesReference
stoichiometry: 1.0
species: 326539

102290
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328091
type: Reaction
kinetic law: 101278
product: 101266
reactant: 101253
fast: false
reversible: true
name: v587 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60

101266
type: SpeciesReference
stoichiometry: 1.0
species: 326641

101253
type: SpeciesReference
stoichiometry: 1.0
species: 326331

327655
type: Reaction
kinetic law: 091686
product: 091674
reactant: 091662
reactant: 091650
fast: false
reversible: true
name: v364 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21

091674
type: SpeciesReference
stoichiometry: 1.0
species: 326313

091662
type: SpeciesReference
stoichiometry: 1.0
species: 326541

091650
type: SpeciesReference
stoichiometry: 1.0
species: 326321

327945
type: Reaction
kinetic law: 098489
product: 098477
reactant: 098465
reactant: 098453
fast: false
reversible: true
name: v509 ERK + (MEK#P#P)_i -> MEK#P#P:ERK k52 kd44

098477
type: SpeciesReference
stoichiometry: 1.0
species: 326621

098465
type: SpeciesReference
stoichiometry: 1.0
species: 326601

098453
type: SpeciesReference
stoichiometry: 1.0
species: 326613

328239
type: Reaction
kinetic law: 104592
product: 104580
reactant: 104568
reactant: 104556
fast: false
reversible: true
name: v661 RTK_Pase + 2(ErbB2) -> 2(ErbB2)#P:RTK_Pase k95 kd95

104580
type: SpeciesReference
stoichiometry: 1.0
species: 326763

104568
type: SpeciesReference
stoichiometry: 1.0
species: 326643

104556
type: SpeciesReference
stoichiometry: 1.0
species: 326755

329385
type: Parameter
constant: true
value: 0.0
name: k123

327881
type: Reaction
kinetic law: 096944
product: 096932
reactant: 096920
reactant: 096908
fast: false
reversible: true
name: v477 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41

096932
type: SpeciesReference
stoichiometry: 1.0
species: 326108

096920
type: SpeciesReference
stoichiometry: 1.0
species: 326531

096908
type: SpeciesReference
stoichiometry: 1.0
species: 326577

327349
type: Reaction
kinetic law: 084264
product: 084252
reactant: 084240
fast: false
reversible: true
name: v211 cPP + -> cPP k15 kd15

084252
type: SpeciesReference
stoichiometry: 1.0
species: 326056

084240
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327183
type: Reaction
kinetic law: 080644
product: 080632
reactant: 080620
reactant: 080608
fast: false
reversible: true
name: v124 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b

080632
type: SpeciesReference
stoichiometry: 1.0
species: 326227

080620
type: SpeciesReference
stoichiometry: 1.0
species: 326351

080608
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327933
type: Reaction
kinetic law: 098199
product: 098187
reactant: 098175
reactant: 098163
fast: false
reversible: true
name: v503 MEK + Pase2 -> (MEK#P:Pase2)_i k49 kd49

098187
type: SpeciesReference
stoichiometry: 1.0
species: 326611

098175
type: SpeciesReference
stoichiometry: 1.0
species: 326603

098163
type: SpeciesReference
stoichiometry: 1.0
species: 326589

327379
type: Reaction
kinetic law: 084986
product: 084974
reactant: 084962
reactant: 084950
fast: false
reversible: true
name: v226 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

084974
type: SpeciesReference
stoichiometry: 1.0
species: 326405

084962
type: SpeciesReference
stoichiometry: 1.0
species: 326533

084950
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328559
type: Reaction
kinetic law: 112301
product: 112288
reactant: 112275
reactant: 112262
fast: false
reversible: true
name: v822 (ErbB1:ErbB3)#P + ATP -> (HRG:ErbB3:ErbB1):ATP k123 kd123

112288
type: SpeciesReference
stoichiometry: 1.0
species: 326032

112275
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112262
type: SpeciesReference
stoichiometry: 1.0
species: 326465

328393
type: Reaction
kinetic law: 108303
product: 108290
reactant: 108278
reactant: 108266
fast: false
reversible: true
name: v738 (ERK#P#P)_i + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111

108290
type: SpeciesReference
stoichiometry: 1.0
species: 326843

108278
type: SpeciesReference
stoichiometry: 1.0
species: 326849

108266
type: SpeciesReference
stoichiometry: 1.0
species: 326629

328589
type: Reaction
kinetic law: 113035
product: 113023
reactant: 113011
reactant: 112999
fast: false
reversible: true
name: v857 2(EGF:ErbB1_h:ATP) + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k122 kd122

113023
type: SpeciesReference
stoichiometry: 1.0
species: 326943

113011
type: SpeciesReference
stoichiometry: 1.0
species: 325980

112999
type: SpeciesReference
stoichiometry: 1.0
species: 326933

327737
type: Reaction
kinetic law: 093488
product: 093476
reactant: 093464
reactant: 093452
fast: false
reversible: true
name: v405 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25

093476
type: SpeciesReference
stoichiometry: 1.0
species: 326253

093464
type: SpeciesReference
stoichiometry: 1.0
species: 326249

093452
type: SpeciesReference
stoichiometry: 1.0
species: 326539

328257
type: Reaction
kinetic law: 105025
product: 105013
reactant: 105001
reactant: 104989
fast: false
reversible: true
name: v670 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) k101 kd101

105013
type: SpeciesReference
stoichiometry: 1.0
species: 326673

105001
type: SpeciesReference
stoichiometry: 1.0
species: 326419

104989
type: SpeciesReference
stoichiometry: 1.0
species: 326671

327127
type: Reaction
kinetic law: 079297
product: 079285
reactant: 079273
reactant: 079261
fast: false
reversible: true
name: v95 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4

079285
type: SpeciesReference
stoichiometry: 1.0
species: 326279

079273
type: SpeciesReference
stoichiometry: 1.0
species: 326056

079261
type: SpeciesReference
stoichiometry: 1.0
species: 326277

327411
type: Reaction
kinetic law: 085760
product: 085748
reactant: 085736
reactant: 085724
fast: false
reversible: true
name: v242 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17

085748
type: SpeciesReference
stoichiometry: 1.0
species: 326321

085736
type: SpeciesReference
stoichiometry: 1.0
species: 326327

085724
type: SpeciesReference
stoichiometry: 1.0
species: 326539

327397
type: Reaction
kinetic law: 085422
product: 085410
reactant: 085398
reactant: 085386
fast: false
reversible: true
name: v235 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24

085410
type: SpeciesReference
stoichiometry: 1.0
species: 326249

085398
type: SpeciesReference
stoichiometry: 1.0
species: 326457

085386
type: SpeciesReference
stoichiometry: 1.0
species: 326521

328301
type: Reaction
kinetic law: 106087
product: 106075
reactant: 106063
reactant: 106051
fast: false
reversible: true
name: v692 2(ErbB2)#P:GAP:Grb2 + Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1 k105 kd105

106075
type: SpeciesReference
stoichiometry: 1.0
species: 326014

106063
type: SpeciesReference
stoichiometry: 1.0
species: 326801

106051
type: SpeciesReference
stoichiometry: 1.0
species: 326229

327661
type: Reaction
kinetic law: 091830
product: 091818
reactant: 091806
reactant: 091794
fast: false
reversible: true
name: v367 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22

091818
type: SpeciesReference
stoichiometry: 1.0
species: 326433

091806
type: SpeciesReference
stoichiometry: 1.0
species: 326429

091794
type: SpeciesReference
stoichiometry: 1.0
species: 326551

327051
type: Reaction
kinetic law: 077466
product: 077453
reactant: 077441
reactant: 077429
fast: false
reversible: true
name: v54 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k4b kd4

077453
type: SpeciesReference
stoichiometry: 1.0
species: 326098

077441
type: SpeciesReference
stoichiometry: 1.0
species: 326056

077429
type: SpeciesReference
stoichiometry: 1.0
species: 326096

327857
type: Reaction
kinetic law: 096368
product: 096355
reactant: 096343
reactant: 096330
fast: false
reversible: true
name: v465 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37

096355
type: SpeciesReference
stoichiometry: 1.0
species: 326451

096343
type: SpeciesReference
stoichiometry: 1.0
species: 326523

096330
type: SpeciesReference
stoichiometry: 1.0
species: 326511

327211
type: Reaction
kinetic law: 081318
product: 081305
reactant: 081293
reactant: 081281
fast: false
reversible: true
name: v140 cPP + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k5 kd5b

081305
type: SpeciesReference
stoichiometry: 1.0
species: 326142

081293
type: SpeciesReference
stoichiometry: 1.0
species: 326379

081281
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327159
type: Reaction
kinetic law: 080068
product: 080056
reactant: 080044
reactant: 080032
fast: false
reversible: true
name: v111 cPP + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k5b kd5b

080056
type: SpeciesReference
stoichiometry: 1.0
species: 326275

080044
type: SpeciesReference
stoichiometry: 1.0
species: 326327

080032
type: SpeciesReference
stoichiometry: 1.0
species: 326309

327909
type: Reaction
kinetic law: 097621
product: 097609
reactant: 097597
reactant: 097585
fast: false
reversible: true
name: v491 (Raf#P)_i + (MEK#P)_i -> (MEK#P:Raf#P)_i k44 kd52

097609
type: SpeciesReference
stoichiometry: 1.0
species: 326587

097597
type: SpeciesReference
stoichiometry: 1.0
species: 326585

097585
type: SpeciesReference
stoichiometry: 1.0
species: 326571

326951
type: Reaction
kinetic law: 075024
product: 075012
reactant: 075000
reactant: 074988
fast: false
reversible: true
name: v3 ErbB2:ErbB4 + EGF -> (ErbB4:ErbB2)#P k1d kd1d

075012
type: SpeciesReference
stoichiometry: 1.0
species: 325922

075000
type: SpeciesReference
stoichiometry: 1.0
species: 325910

074988
type: SpeciesReference
stoichiometry: 1.0
species: 325920