BIOMD0000000248
type: SBMLModel
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curated: true
length unit: length
parameter: metaid_0000048
rule: metaid_0000106
species: metaid_0000040
units def: metaid_0000036
units def: metaid_0000045
area units: metaid_0000005
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parameter: metaid_0000094
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units def: metaid_0000005
name: Lai2007_O2_Transport_Metabolism
species: metaid_0000009
parameter: metaid_0000044
species: metaid_0000041
parameter: metaid_0000098
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parameter: metaid_0000077
is described by: http://identifiers.org/pubmed/17380394
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is: MODEL1004170000
time units: 905439
notes: This file describes the SBML version of the mathematical model in the following journal article: Linking Pulmonary Oxygen Uptake, Muscle Oxygen Utilization and Cellular Metabolism during Exercise, Ann Biomed Eng. 2007 Jun;35(6):956-69. (Pubmed ID: 17380394). This mathematical model simulates oxygen transport and metabolism in skeletal muscle in response to a step change from a warm-up steady state to a higher work rate corresponding to exercise at different levels of intensity: moderate (M), heavy (H) and very heavy (VH). The model parameter values are listed in the tables of this article. The parameter values that are independent of the exercise level are reported in Table 2. The parameter values that depend on the exercise level are reported in Tables 1A, 3 and 4. The model simulations (Figures 2, 3, 4 and 5) were obtained for a representative subject with a set of parameter values different from those in Table 1A, 3 and 4. In the sbml model, these model parameters are used to simulate exercise at a very heavy (VH) intensity for the representative subject. Additionally, the parameter values needed to simulate exercise at moderate (M) and heavy (H) intensity are reported in the list of parameters of the file. The model simulates dynamics of (1) the concentrations of free (F) and total (T) oxygen concentration in blood (CFcap, CTcap) and tissue (CFtis, CTtis), Adenosine Triphosphate (ATP), Adenosine Diphosphate (ADP), Phosphocreatine (PCr) and Creatine (Cr); (2) the metabolic flux of oxidative phosphorylation, creatine kinase and ATPase; (3) the oxygen uptake in blood and oxygen transport rate from blood to tissue during exercise. The simulation also computes muscle oxygen saturation (StO2m) and relative muscle oxygen saturation (RStO2m) in order to compare simulated and experimental responses of human muscle oxygenation during exercise. The model was successfully tested with Roadrunner of the Systems Biology Workbench (SBW). The model simulations obtained with Road…
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metaid_0000017
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value: 3.8
name: Kp

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metaid_0000012
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name: Katpase

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metaid_0000094
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metaid_0000090
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metaid_0000080
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metaid_0000009
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is: CHEBI:17287
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metaid_0000088
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name: exercise_level

metaid_0000077
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metaid_0000063
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metaid_0000109
type: Parameter
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name: oxygen_phosphorilation_rate_mM

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metaid_0000015
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metaid_0000019
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kinetic law: 926497
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metaid_0000087
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name: StO2mW

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name: KatpaseM

metaid_0000083
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value: 5.18
name: CrbcHb

metaid_0000072
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value: 3.118
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metaid_0000108
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name: CK_flux_mM

metaid_0000092
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value: 23.11702
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name: KatpaseE

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value: 3.0
name: tE

metaid_0000069
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value: 0.688
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value: 0.45
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reversible: true
name: ConvectionTransport

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value: 6000.0
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value: 23.11702
name: Vmax

metaid_0000100
type: Parameter
constant: true
units: metaid_0000036
value: 0.396
name: tauQmH

metaid_0000018
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units: metaid_0000014
value: 1.11
name: Kb

metaid_0000013
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value: 0.135
name: Kia

metaid_0000082
type: Parameter
constant: true
units: metaid_0000014
value: 7800.7
name: KHb

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type: Parameter
constant: true
units: metaid_0000045
value: 3.118
name: QWm

metaid_0000065
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units: metaid_0000004
value: 0.3207601
name: KatpaseW

ORG:
  orgname: Case Western Reserve University
n:
  given: Nicola
  family: Lai

metaid_0000099
type: Parameter
constant: true
units: metaid_0000036
value: 0.32
name: tauQmM

metaid_0000089
type: Parameter
constant: false
units: metaid_0000005
value: NaN
name: ATPase_flux_mM

W3 CDTF: Fri Oct 16 21:26:03 BST 2009

metaid_0000091
type: Parameter
constant: true
units: metaid_0000005
value: 34.68714
name: VmaxH

metaid_0000095
type: Parameter
constant: true
units: metaid_0000004
value: 3.3423645
name: KatpaseVH

metaid_0000074
type: Parameter
constant: true
units: metaid_0000060
value: 308.642
name: KMb

ORG:
  orgname: Case Western Reserve University
n:
  given: Justin
  family: Chiou

W3 CDTF: Fri Apr 20 23:18:01 BST 2012