BIOMD0000000244
type: SBMLModel
parameter: metaid_0000091
reaction: metaid_0000376
parameter: metaid_0000117
parameter: metaid_0000202
parameter: metaid_0000062
reaction: metaid_0000365
parameter: metaid_0000124
parameter: metaid_0000078
rule: metaid_0000267
parameter: metaid_0000163
has version: GO:0006083
parameter: metaid_0000060
notes: This is the model described in: Bacterial adaptation through distributed sensing of metabolic fluxes Oliver Kotte, Judith B Zaugg and Matthias Heinemann; Mol Sys Biol 2010; 6 :355. doi: 10.1038/msb.2010.10 ; Abstract: The recognition of carbon sources and the regulatory adjustments to recognized changes are of particular importance for bacterial survival in fluctuating environments. Despite a thorough knowledge base of Escherichia coli's central metabolism and its regulation, fundamental aspects of the employed sensing and regulatory adjustment mechanisms remain unclear. In this paper, using a differential equation model that couples enzymatic and transcriptional regulation of E. coli's central metabolism, we show that the interplay of known interactions explains in molecular-level detail the system-wide adjustments of metabolic operation between glycolytic and gluconeogenic carbon sources. We show that these adaptations are enabled by an indirect recognition of carbon sources through a mechanism we termed distributed sensing of intracellular metabolic fluxes. This mechanism uses two general motifs to establish flux-signaling metabolites, whose bindings to transcription factors form flux sensors. As these sensors are embedded in global feedback loop architectures, closed-loop self-regulation can emerge within metabolism itself and therefore, metabolic operation may adapt itself autonomously (not requiring upstream sensing and signaling) to fluctuating carbon sources. In its current form this SBML model is parametrized for the glucose to acetate transition and to simulate the extended diauxic shift as shown in figure 3 and scenario 6 of the attached matlab file. In this scenario the cells first are grown from an OD600 (BM) of 0.03 with a starting glucose concentration of 0.5 g/l for 8.15 h (29340 sec). Then a medium containing 5 g/l acetate is inoculated with these cells to an OD600 of 0.03 and grown for another 19.7 hours (70920 sec). Finally the cells are shifted t…
parameter: metaid_0000179
parameter: metaid_0000076
parameter: metaid_0000138
parameter: 533565
parameter: metaid_0000161
rule: metaid_0000265
reaction: metaid_0000272
parameter: metaid_0000177
parameter: metaid_0000083
parameter: metaid_0000131
parameter: metaid_0000099
species: metaid_0000224
parameter: metaid_0000184
reaction: metaid_0000352
parameter: metaid_0000148
parameter: metaid_0000097
parameter: metaid_0000145
parameter: metaid_0000182
parameter: metaid_0000109
reaction: metaid_0000341
parameter: metaid_0000100
parameter: metaid_0000090
reaction: metaid_0000357
parameter: metaid_0000116
species: metaid_0000234
parameter: metaid_0000201
reaction: metaid_0000292
parameter: metaid_0000155
reaction: metaid_0000355
parameter: metaid_0000114
has version: GO:0008965
parameter: metaid_0000068
reaction: metaid_0000290
parameter: metaid_0000153
species: metaid_0000245
is version of: GO:0010906
parameter: metaid_0000169
parameter: metaid_0000075
species: metaid_0000219
parameter: metaid_0000160
parameter: metaid_0000026
species: metaid_0000252
parameter: metaid_0000176
parameter: metaid_0000073
parameter: metaid_0000121
species: metaid_0000235
reaction: metaid_0000278
parameter: 533562
parameter: metaid_0000089
parameter: metaid_0000174
has version: GO:0006094
reaction: metaid_0000333
species: metaid_0000242
parameter: metaid_0000144
parameter: metaid_0000108
species: metaid_0000228
reaction: metaid_0000331
parameter: metaid_0000080
parameter: metaid_0000142
reaction: metaid_0000347
parameter: metaid_0000106
parameter: metaid_0000008
species: metaid_0000253
reaction: metaid_0000282
reaction: metaid_0000312
reaction: metaid_0000354

metaid_0000091
type: Parameter
constant: true
value: 5200000.0
name: e_Ppc_L

metaid_0000376
type: Reaction
kinetic law: 786877
modifier: 786865
modifier: 786853
reactant: 786841
fast: false
reversible: false
name: env_ACTup

metaid_0000210
type: Species
constant: false
boundary condition: false
has only substance units: true
substance units: metaid_0000378
initial concentration: NaN
initial amount: 0.03
in compartment: metaid_0000208
name: BM

metaid_0000378
type: SBMLUnitsDef
unit: 781354
name: OD

781354
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

metaid_0000208
type: Compartment
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: Environment

metaid_0000229
type: Species
has only substance units: true
constant: false
name: Acs
initial concentration: NaN
initial amount: 0.001096222
boundary condition: false
is version of: P27550
is: SBO:0000014
in compartment: metaid_0000209

metaid_0000209
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cell

786841
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000211

metaid_0000211
type: Species
name: ACT
substance units: gram
in compartment: metaid_0000208
has only substance units: false
is version of: C00033
initial amount: 0.0
boundary condition: false
constant: false
initial concentration: NaN
is: SBO:0000247
is version of: CHEBI:15366

metaid_0000117
type: Parameter
constant: true
value: 1.0
name: tf_PdhR_n

metaid_0000202
type: Parameter
constant: false
value: 0.0
name: k_bm_OAA

metaid_0000062
type: Parameter
constant: true
value: 2.0
name: e_Icd_n

metaid_0000365
type: Reaction
kinetic law: 786327
modifier: 786315
modifier: 786303
reactant: 786291
fast: false
reversible: false
name: d_FBP

metaid_0000212
type: Species
boundary condition: false
initial concentration: NaN
name: GLC
constant: false
substance units: gram
initial amount: 4.8
is version of: C00293
is version of: CHEBI:17234
is: SBO:0000247
in compartment: metaid_0000208
has only substance units: false

786291
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000216

metaid_0000216
type: Species
has only substance units: true
initial amount: 6.57504207
is version of: CHEBI:16905
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000209
is: SBO:0000247
is version of: C00354
name: FBP
constant: false

metaid_0000124
type: Parameter
constant: true
value: 0.897
name: g_aceBAK_KP

metaid_0000078
type: Parameter
constant: true
value: 1179.0
name: e_Pdh_kcat

metaid_0000163
type: Parameter
constant: true
value: 0.0
name: g_pckA_vcra_unbound

metaid_0000060
type: Parameter
constant: true
value: 0.63
name: e_GltA_Kakg

metaid_0000179
type: Parameter
constant: true
value: 20000.0
name: bm_k_expr

metaid_0000076
type: Parameter
constant: true
value: 0.184
name: e_PckA_Koaa

metaid_0000138
type: Parameter
constant: true
value: 1.4E-6
name: g_akg2mal_vcrp_bound

533565
type: Parameter
constant: true
units: metaid_0020382
value: 0.0
name: GLC_1

metaid_0020382
type: SBMLUnitsDef
unit: 781427
unit: 781415
name: gram_per_litre

781427
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

781415
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: GRAM

metaid_0000161
type: Parameter
constant: true
value: 9.1E-6
name: g_mdh_vcrp_bound

metaid_0000272
type: Reaction
kinetic law: 781620
modifier: 781608
modifier: 781596
reactant: 781584
fast: false
reversible: false
name: bm_OAA

781584
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000221

metaid_0000221
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: OAA
has only substance units: true
is version of: C00036
in compartment: metaid_0000209
initial concentration: NaN
is version of: CHEBI:30744
initial amount: 0.050535354

metaid_0000177
type: Parameter
constant: true
value: 0.0023
name: g_pykF_Kcra

metaid_0000083
type: Parameter
constant: true
value: 0.218
name: e_Pdh_Kglx

metaid_0000131
type: Parameter
constant: true
value: 2.0E-8
name: g_aceBAK_vcrp_unbound

metaid_0000099
type: Parameter
constant: true
value: 5749.0
name: e_PykF_kcat

metaid_0000224
type: Species
in compartment: metaid_0000209
is: SBO:0000247
is version of: C00022
has only substance units: true
name: PYR
initial amount: 0.863278018
boundary condition: false
initial concentration: NaN
constant: false
is version of: CHEBI:32816

metaid_0000184
type: Parameter
constant: true
value: 0.154
name: bm_GLC_G6P

metaid_0000352
type: Reaction
kinetic law: 785821
modifier: 785809
modifier: 785797
reactant: 785784
fast: false
reversible: false
name: d_Pdh

785784
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000242

metaid_0000242
type: Species
constant: false
in compartment: metaid_0000209
name: Pdh
boundary condition: false
is version of: P0AFG8
has only substance units: true
is: SBO:0000014
initial amount: 0.004647401
initial concentration: NaN

metaid_0000148
type: Parameter
constant: true
value: 0.0
name: g_eno_vcra_bound

metaid_0000097
type: Parameter
constant: true
value: 0.00177
name: e_PpsA_Kpyr

metaid_0000145
type: Parameter
constant: true
value: 4.7E-7
name: g_emp_vcrp_bound

metaid_0000182
type: Parameter
constant: true
value: 1.88
name: bm_GLC_ACoA

metaid_0000109
type: Parameter
constant: true
value: 100.0
name: tf_Cra_scale

metaid_0000341
type: Reaction
kinetic law: 785285
reactant: 785272
fast: false
reversible: false
name: d_Cya

785272
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000232

metaid_0000232
type: Species
initial amount: 0.001
constant: false
is version of: P00936
boundary condition: false
name: Cya
in compartment: metaid_0000209
initial concentration: NaN
has only substance units: true
is: SBO:0000014

metaid_0000100
type: Parameter
constant: true
value: 4.0
name: e_PykF_n

metaid_0000090
type: Parameter
constant: true
value: 3.0
name: e_Ppc_n

metaid_0000357
type: Reaction
kinetic law: 786013
modifier: 786001
modifier: 785989
reactant: 785977
fast: false
reversible: false
name: d_PpsA

785977
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000245

metaid_0000245
type: Species
name: PpsA
boundary condition: false
has only substance units: true
initial amount: 9.87493E-4
initial concentration: NaN
is: SBO:0000014
is version of: B5Z9Q0
constant: false
in compartment: metaid_0000209

metaid_0000116
type: Parameter
constant: true
value: 0.164
name: tf_PdhR_kpyr

metaid_0000234
type: Species
initial amount: 0.011552813
boundary condition: false
is version of: P0A6P9
is: SBO:0000014
has only substance units: true
constant: false
name: Eno
initial concentration: NaN
in compartment: metaid_0000209

metaid_0000201
type: Parameter
constant: false
value: 0.0
name: k_bm_G6P

metaid_0000292
type: Reaction
kinetic law: 782822
modifier: 782810
modifier: 782798
product: 782786
reactant: 782774
fast: false
reversible: false
name: e_Fdp

metaid_0000222
type: Species
has only substance units: true
constant: false
is version of: C00074
is: SBO:0000247
in compartment: metaid_0000209
name: PEP
boundary condition: false
initial concentration: NaN
is version of: CHEBI:18021
initial amount: 0.210455879

metaid_0000235
type: Species
boundary condition: false
is homolog to: P00637
in compartment: metaid_0000209
initial amount: 1.57492E-4
has only substance units: true
is: SBO:0000014
constant: false
initial concentration: NaN
name: Fdp

782786
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000217

metaid_0000217
type: Species
in compartment: metaid_0000209
is version of: CHEBI:14314
constant: false
is version of: C00092
boundary condition: false
initial concentration: NaN
name: G6P
initial amount: 1.908140784
is: SBO:0000247
has only substance units: true

782774
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000216

metaid_0000155
type: Parameter
constant: true
value: 0.04
name: g_gltA_Kcrp

metaid_0000355
type: Reaction
kinetic law: 785917
modifier: 785905
modifier: 785893
reactant: 785881
fast: false
reversible: false
name: d_PfkA

785881
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000243

metaid_0000243
type: Species
in compartment: metaid_0000209
name: PfkA
initial concentration: NaN
is: SBO:0000014
is version of: P06999
boundary condition: false
initial amount: 1.43816E-4
has only substance units: true
constant: false

metaid_0000114
type: Parameter
constant: true
value: 1.0
name: tf_Crp_n

metaid_0000068
type: Parameter
constant: true
value: 10.1
name: e_Mdh_Kmal

metaid_0000290
type: Reaction
kinetic law: 782714
modifier: 782702
product: 782690
reactant: 782677
fast: false
reversible: true
name: e_Emp

metaid_0000233
type: Species
is: SBO:0000014
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.011515593
in compartment: metaid_0000209
name: Emp

782690
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000223

metaid_0000223
type: Species
is version of: C00197
name: PG3
has only substance units: true
initial amount: 5.720977255
is version of: CHEBI:17794
boundary condition: false
constant: false
initial concentration: NaN
is: SBO:0000247
in compartment: metaid_0000209

782677
type: SpeciesReference
stoichiometry: 0.5
species: metaid_0000216

metaid_0000153
type: Parameter
constant: true
value: 0.0
name: g_gltA_vcrp_unbound

metaid_0000169
type: Parameter
constant: true
value: 8.2E-7
name: g_pfkA_vcra_unbound

metaid_0000075
type: Parameter
constant: true
value: 55.5
name: e_PckA_kcat

metaid_0000219
type: Species
is: SBO:0000247
in compartment: metaid_0000209
constant: false
name: ICT
has only substance units: true
is version of: C00311
boundary condition: false
is version of: CHEBI:30887
initial concentration: NaN
initial amount: 0.001408116

metaid_0000160
type: Parameter
constant: true
value: 0.0
name: g_mdh_vcrp_unbound

metaid_0000026
type: Parameter
constant: true
value: 0.866
name: e_AceK_Kglx

metaid_0000252
type: Species
initial amount: 0.001163813
in compartment: metaid_0000209
is version of: P0ACM1
constant: false
boundary condition: false
is: SBO:0000245
has only substance units: true
name: PdhR
initial concentration: NaN

metaid_0000176
type: Parameter
constant: true
value: 2.1E-9
name: g_pykF_vcra_bound

metaid_0000073
type: Parameter
constant: true
value: 3.64
name: e_Me_Kacoa

metaid_0000121
type: Parameter
constant: true
value: 0.3
name: g_aceBAK_aceBfactor

metaid_0000278
type: Reaction
reversible: false
modifier: 782023
modifier: 782011
modifier: 781937
kinetic law: 782035
modifier: 781998
modifier: 781974
modifier: 781962
modifier: 781986
fast: false
modifier: 781950
name: e_AceK_Ki
reactant: 781913
is version of: GO:0006468
product: 781925

metaid_0000214
type: Species
boundary condition: false
is version of: CHEBI:16810
constant: false
initial concentration: NaN
has only substance units: true
name: AKG
is: SBO:0000247
in compartment: metaid_0000209
is version of: C00026
initial amount: 0.191190619

metaid_0000218
type: Species
initial amount: 5.70593E-9
has only substance units: true
name: GLX
is version of: C00048
boundary condition: false
is: SBO:0000247
initial concentration: NaN
constant: false
is version of: CHEBI:16891
in compartment: metaid_0000209

metaid_0000227
type: Species
name: AceK
initial concentration: NaN
has only substance units: true
is version of: P11071
boundary condition: false
initial amount: 1.41697E-4
constant: false
is: SBO:0000014
in compartment: metaid_0000209

781913
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000237

metaid_0000237
type: Species
in compartment: metaid_0000209
name: Icd
has only substance units: true
initial amount: 0.004290789
is version of: P08200
is: SBO:0000014
constant: false
boundary condition: false
initial concentration: NaN

781925
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000238

metaid_0000238
type: Species
boundary condition: false
initial concentration: NaN
initial amount: 2.20477E-4
has only substance units: true
is: SBO:0000014
constant: false
name: Icd_P
is version of: P08200
in compartment: metaid_0000209

533562
type: Parameter
constant: true
units: metaid_0001382
value: 27.85
name: shift2

metaid_0001382
type: SBMLUnitsDef
unit: 781403
name: hours

781403
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

metaid_0000089
type: Parameter
constant: true
value: 5635.0
name: e_Ppc_kcat

metaid_0000174
type: Parameter
constant: true
value: 0.017
name: g_ppsA_Kcra

metaid_0000333
type: Reaction
kinetic law: 785026
reactant: 785013
fast: false
reversible: false
name: d_Acoa2act

785013
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000228

metaid_0000228
type: Species
is: SBO:0000014
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000209
name: Acoa2act

metaid_0000144
type: Parameter
constant: true
value: 0.0
name: g_emp_vcrp_unbound

metaid_0000108
type: Parameter
constant: true
value: 0.0012
name: pts_Kglc

metaid_0000331
type: Reaction
kinetic law: 784952
modifier: 784940
modifier: 784927
reactant: 784915
fast: false
reversible: false
name: d_AceB

784915
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000226

metaid_0000226
type: Species
initial amount: 0.001416969
constant: false
is: SBO:0000014
in compartment: metaid_0000209
boundary condition: false
name: AceB
initial concentration: NaN
is version of: Q8X609
has only substance units: true

metaid_0000080
type: Parameter
constant: true
value: 3.4
name: e_Pdh_L

metaid_0000142
type: Parameter
constant: true
value: 0.0
name: g_emp_vcra_bound

metaid_0000347
type: Reaction
kinetic law: 785597
modifier: 785584
modifier: 785571
reactant: 785558
fast: false
reversible: false
name: d_Icd_P

785558
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000238

metaid_0000106
type: Parameter
constant: true
value: 2520.0
name: pts_k4

metaid_0000008
type: Parameter
constant: true
value: 50100.0
name: e_AceA_L

metaid_0000253
type: Species
name: PdhRPYR
boundary condition: false
initial amount: 0.006126187
in compartment: metaid_0000209
has only substance units: true
is part of: CHEBI:32816
is part of: P0ACM1
constant: false
initial concentration: NaN
is: SBO:0000253

metaid_0000282
type: Reaction
kinetic law: 782288
modifier: 782275
product: 782263
reactant: 782251
is version of: GO:0043234
fast: false
reversible: true
name: tf_PdhR

782263
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000253

782251
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000252

metaid_0000312
type: Reaction
kinetic law: 783980
product: 783968
fast: false
reversible: false
name: g_cya

783968
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000232

metaid_0000354
type: Reaction
kinetic law: 785869
reactant: 785857
fast: false
reversible: false
name: d_PdhRPYR

785857
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000253

metaid_0000207
type: Parameter
constant: false
value: 0.0
name: SS_Ppc

metaid_0000067
type: Parameter
constant: true
value: 1.7
name: e_Mdh_n

metaid_0000152
type: Parameter
constant: true
value: 0.00118
name: g_fdp_Kcra

metaid_0000054
type: Parameter
constant: true
value: 0.003
name: e_Fdp_Kfbp

metaid_0000301
type: Reaction
kinetic law: 783354
modifier: 783342
product: 783329
reactant: 783317
fast: false
reversible: false
name: e_PpsA

783329
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

783317
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000224

metaid_0000018
type: Parameter
constant: true
value: 1.7E9
name: e_AceK_kcat_ph

metaid_0000168
type: Parameter
constant: true
value: 0.0034
name: g_pdh_Kpdhr

metaid_0000065
type: Parameter
constant: true
value: 0.334
name: e_Icd_Kpep

metaid_0000317
type: Reaction
kinetic law: 784294
modifier: 784282
modifier: 784269
modifier: 784257
product: 784245
fast: false
reversible: false
name: g_icd

metaid_0000247
type: Species
in compartment: metaid_0000209
boundary condition: false
has only substance units: true
initial amount: 2.99098E-4
is: SBO:0000245
name: Cra
initial concentration: NaN
constant: false
is version of: P0ACP1

784245
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000237

metaid_0000368
type: Reaction
kinetic law: 786474
modifier: 786461
modifier: 786448
reactant: 786436
fast: false
reversible: false
name: d_ICT

786436
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000219

metaid_0000150
type: Parameter
constant: true
value: 0.0
name: g_fdp_vcra_unbound

metaid_0000052
type: Parameter
constant: true
value: 4.0
name: e_Fdp_n

metaid_0000016
type: Parameter
constant: true
value: 0.719
name: e_AceB_Kglxacoa

metaid_0000166
type: Parameter
constant: true
value: 3.6E-7
name: g_pdh_vpdhr_unbound

533425
type: Event
event assignment: 786997
event assignment: 786985
event assignment: 786973
trigger: 786961
use values from trigger time: true
name: first shift

786961
type: Trigger
persistant: true
initial value: true

metaid_0000315
type: Reaction
kinetic law: 784172
modifier: 784160
modifier: 784148
modifier: 784136
product: 784124
fast: false
reversible: false
name: g_fdp

784124
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000235

metaid_0000120
type: Parameter
constant: true
value: 0.00365
name: g_aceBAK_Kcra

metaid_0000277
type: Reaction
fast: false
product: 781864
is part of: GO:0009401
reactant: 781840
product: 781852
is version of: GO:0006470
name: pts_r4
reversible: false
modifier: 781876
kinetic law: 781901
modifier: 781889

781864
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000254

metaid_0000254
type: Species
initial amount: 0.09647707
constant: false
in compartment: metaid_0000209
is: SBO:0000014
is part of: GO:0009401
boundary condition: false
name: EIIA
has only substance units: true
is part of: P00550
initial concentration: NaN

781840
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000255

metaid_0000255
type: Species
is part of: GO:0009401
has only substance units: true
name: EIIA_P
is: SBO:0000014
is part of: P00550
in compartment: metaid_0000209
initial amount: 0.00352292
initial concentration: NaN
constant: false
boundary condition: false

781852
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000217

metaid_0000256
type: Species
in compartment: metaid_0000209
is: SBO:0000014
has only substance units: true
initial amount: 0.003
initial concentration: NaN
boundary condition: false
name: EIICB
is part of: GO:0009401
constant: false
is part of: P00550

metaid_0000249
type: Species
boundary condition: false
is: SBO:0000245
is version of: P0ACJ8
initial amount: 0.005943273
has only substance units: true
initial concentration: NaN
name: Crp
constant: false
in compartment: metaid_0000209

533568
type: Parameter
constant: true
units: metaid_0020382
value: 3.0
name: GLC_2

metaid_0000039
type: Parameter
constant: true
value: 1000.0
name: e_CAMPdegr_kcat

metaid_0000323
type: Reaction
kinetic law: 784576
product: 784564
fast: false
reversible: false
name: g_pdhr

784564
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000252

metaid_0000275
type: Reaction
kinetic law: 781768
modifier: 781756
modifier: 781744
reactant: 781732
fast: false
reversible: false
name: bm_PYR

781732
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000224

metaid_0000134
type: Parameter
constant: true
value: 1.2E-6
name: g_acs_vcrp_bound

metaid_0000220
type: Species
in compartment: metaid_0000209
is version of: C00497
has only substance units: true
initial concentration: NaN
name: MAL
is version of: CHEBI:30796
constant: false
initial amount: 3.278779135
boundary condition: false
is: SBO:0000247

metaid_0000239
type: Species
has only substance units: true
in compartment: metaid_0000209
name: Mdh
is: SBO:0000014
constant: false
initial amount: 0.00345727
is version of: P61889
boundary condition: false
initial concentration: NaN

metaid_0000330
type: Reaction
kinetic law: 784903
modifier: 784890
modifier: 784878
reactant: 784866
fast: false
reversible: false
name: d_AceA

784866
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000225

metaid_0000225
type: Species
boundary condition: false
initial concentration: NaN
initial amount: 0.00472323
name: AceA
has only substance units: true
constant: false
is: SBO:0000014
in compartment: metaid_0000209
is version of: P0A9G6

metaid_0000191
type: Parameter
constant: true
value: 0.076
name: bm_ACT_G6P

metaid_0000346
type: Reaction
kinetic law: 785545
modifier: 785532
modifier: 785519
reactant: 785506
fast: false
reversible: false
name: d_Icd

785506
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000237

metaid_0000007
type: Parameter
constant: true
value: 4.0
name: e_AceA_n

metaid_0000030
type: Parameter
constant: true
value: 3079.0
name: e_Acoa2act_kcat

metaid_0000281
type: Reaction
kinetic law: 782239
modifier: 782227
product: 782215
reactant: 782203
is version of: GO:0043234
fast: false
reversible: true
name: tf_Crp

metaid_0000215
type: Species
is version of: CHEBI:17489
in compartment: metaid_0000209
has only substance units: true
name: cAMP
initial concentration: NaN
initial amount: 0.202804098
is: SBO:0000247
boundary condition: false
constant: false
is version of: C00575

782215
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000250

metaid_0000250
type: Species
initial amount: 0.001346727
is version of: P0ACJ8
constant: false
in compartment: metaid_0000209
name: CrpcAMP
is version of: CHEBI:17489
initial concentration: NaN
boundary condition: false
has only substance units: true
is: SBO:0000253

782203
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000249

metaid_0000046
type: Parameter
constant: true
value: 16.6
name: e_Emp_Kpg3

metaid_0000344
type: Reaction
kinetic law: 785441
modifier: 785428
modifier: 785415
reactant: 785402
fast: false
reversible: false
name: d_Fdp

785402
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000235

metaid_0000005
type: Parameter
constant: true
value: 9.5E-7
name: env_uc

metaid_0000093
type: Parameter
constant: true
value: 0.408
name: e_Ppc_Kfbp

metaid_0000044
type: Parameter
constant: true
value: 848.0
name: e_Emp_kcat_r

metaid_0000295
type: Reaction
kinetic law: 783004
modifier: 782992
product: 782979
reactant: 782967
fast: false
reversible: false
name: e_Mdh

782979
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000221

782967
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000220

metaid_0000158
type: Parameter
constant: true
value: 8.5E-7
name: g_icd_vcra_bound

metaid_0000307
type: Reaction
kinetic law: 783824
modifier: 783812
modifier: 783800
modifier: 783788
product: 783776
fast: false
reversible: false
name: g_acs

783776
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000229

533580
type: Parameter
constant: true
value: 5.0E-4
name: BM_2

metaid_0000349
type: Reaction
kinetic law: 785675
modifier: 785662
modifier: 785649
reactant: 785636
fast: false
reversible: false
name: d_Mdh

785636
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000239

metaid_0000051
type: Parameter
constant: true
value: 192.0
name: e_Fdp_kcat

metaid_0000015
type: Parameter
constant: true
value: 0.755
name: e_AceB_Kacoa

metaid_0000314
type: Reaction
kinetic law: 784112
modifier: 784100
modifier: 784088
modifier: 784076
product: 784064
fast: false
reversible: false
name: g_eno

784064
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000234

metaid_0000284
type: Reaction
fast: false
name: e_AceB
is version of: R00472
reversible: false
product: 782410
reactant: 782398
kinetic law: 782434
modifier: 782422
reactant: 782386

782410
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000220

782398
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000218

782386
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000213

metaid_0000213
type: Species
is: SBO:0000247
initial concentration: NaN
name: ACoA
is version of: C00024
has only substance units: true
constant: false
initial amount: 0.351972298
boundary condition: false
in compartment: metaid_0000209
is version of: CHEBI:15351

metaid_0000110
type: Parameter
constant: true
value: 1.36
name: tf_Cra_kfbp

metaid_0000012
type: Parameter
constant: true
value: 0.827
name: e_AceA_Kakg

metaid_0000029
type: Parameter
constant: true
value: 0.137
name: e_AceK_Kict

metaid_0000322
type: Reaction
kinetic law: 784552
modifier: 784540
modifier: 784527
modifier: 784515
product: 784503
fast: false
reversible: false
name: g_pdh

784503
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000242

metaid_0000298
type: Reaction
kinetic law: 783185
modifier: 783173
modifier: 783161
product: 783149
reactant: 783137
fast: false
reversible: false
name: e_Pdh

783149
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000213

783137
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000224

metaid_0000022
type: Parameter
constant: true
value: 0.643
name: e_AceK_Kicd_P

metaid_0000199
type: Parameter
constant: false
value: 0.0
name: k_bm_ACoA

metaid_0000320
type: Reaction
kinetic law: 784429
modifier: 784417
modifier: 784404
product: 784392
fast: false
reversible: false
name: g_me

784392
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000240

metaid_0000240
type: Species
initial amount: 9.99714E-4
name: Me
in compartment: metaid_0000209
constant: false
boundary condition: false
has only substance units: true
is version of: P76558
is: SBO:0000014
initial concentration: NaN

metaid_0000336
type: Reaction
kinetic law: 785154
reactant: 785141
fast: false
reversible: false
name: d_CAMPdegr

785141
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000231

metaid_0000231
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000209
name: CAMPdegr

metaid_0000020
type: Parameter
constant: true
value: 1.0E8
name: e_AceK_L

metaid_0000197
type: Parameter
constant: false
value: 0.0
name: alphaACT

metaid_0000036
type: Parameter
constant: true
value: 0.001
name: e_Acs_Kact

metaid_0000361
type: Reaction
kinetic law: 786133
reactant: 786121
fast: false
reversible: false
name: d_EIICB

786121
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000256

metaid_0000325
type: Reaction
kinetic law: 784685
modifier: 784672
modifier: 784660
product: 784648
fast: false
reversible: false
name: g_ppc

784648
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000244

metaid_0000244
type: Species
name: Ppc
has only substance units: true
constant: false
in compartment: metaid_0000209
initial concentration: NaN
is: SBO:0000014
boundary condition: false
initial amount: 9.99714E-4
is homolog to: Q9XHC7

metaid_0000043
type: Parameter
constant: true
value: 1000.0
name: e_Emp_kcat_f

metaid_0000059
type: Parameter
constant: true
value: 0.029
name: e_GltA_Koaaacoa

metaid_0000375
type: Reaction
kinetic law: 786829
modifier: 786817
modifier: 786805
modifier: 786793
reactant: 786781
fast: false
reversible: false
name: env_GLCup

786781
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000212

metaid_0000306
type: Reaction
kinetic law: 783764
product: 783752
fast: false
reversible: false
name: g_acoa2act

783752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000228

metaid_0000339
type: Reaction
kinetic law: 785233
reactant: 785220
fast: false
reversible: false
name: d_Crp

785220
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000249

metaid_0000041
type: Parameter
constant: true
value: 993.0
name: e_Cya_kcat

metaid_0000057
type: Parameter
constant: true
value: 0.029
name: e_GltA_Koaa

metaid_0000304
type: Reaction
product: 783534
modifier: 783571
modifier: 783595
modifier: 783559
modifier: 783546
name: g_aceB
reversible: false
kinetic law: 783632
modifier: 783583
modifier: 783619
fast: false
modifier: 783607

783534
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000226

metaid_0000251
type: Species
boundary condition: false
has only substance units: true
initial amount: 0.00729
initial concentration: NaN
in compartment: metaid_0000209
is: SBO:0000245
constant: false
is version of: P16528
name: IclR

metaid_0000011
type: Parameter
constant: true
value: 0.72
name: e_AceA_Kpg3

metaid_0000123
type: Parameter
constant: true
value: 2.19
name: g_aceBAK_KDNA

metaid_0000139
type: Parameter
constant: true
value: 0.091
name: g_akg2mal_Kcrp

metaid_0000297
type: Reaction
kinetic law: 783124
modifier: 783112
product: 783100
reactant: 783088
fast: false
reversible: false
name: e_PckA

metaid_0000241
type: Species
is homolog to: Q8GH15
constant: false
initial concentration: NaN
is: SBO:0000014
initial amount: 0.002290892
boundary condition: false
has only substance units: true
name: PckA
in compartment: metaid_0000209

783100
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

783088
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000221

metaid_0000309
type: Reaction
kinetic law: 783908
product: 783896
fast: false
reversible: false
name: g_cAMPdegr

783896
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000231

metaid_0000137
type: Parameter
constant: true
value: 0.0
name: g_akg2mal_vcrp_unbound

metaid_0000082
type: Parameter
constant: true
value: 0.231
name: e_Pdh_KpyrI

metaid_0000269
type: Reaction
kinetic law: 781475
modifier: 781463
modifier: 781451
reactant: 781439
fast: false
reversible: false
name: bm_ACoA

781439
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000213

metaid_0000196
type: Parameter
constant: false
value: 0.0
name: alphaGLC

metaid_0000098
type: Parameter
constant: true
value: 0.001
name: e_PpsA_Kpep

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000183
type: Parameter
constant: true
value: 0.978
name: bm_GLC_AKG

metaid_0000035
type: Parameter
constant: true
value: 340.0
name: e_Acs_kcat

metaid_0000351
type: Reaction
kinetic law: 785772
modifier: 785760
modifier: 785748
reactant: 785736
fast: false
reversible: false
name: d_PckA

785736
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000241

metaid_0000147
type: Parameter
constant: true
value: 6.8E-7
name: g_eno_vcra_unbound

metaid_0000194
type: Parameter
constant: true
value: 0.066
name: bm_ACT_PG3

metaid_0000096
type: Parameter
constant: true
value: 1.0E-79
name: e_PpsA_L

metaid_0000181
type: Parameter
constant: true
value: 1.8E-4
name: bm_muGLC

metaid_0000033
type: Parameter
constant: true
value: 0.022
name: e_Acoa2act_Kacoa

metaid_0000246
type: Species
has only substance units: true
name: PykF
initial concentration: NaN
in compartment: metaid_0000209
is version of: P0AD61
is: SBO:0000014
initial amount: 0.005977168
boundary condition: false
constant: false

metaid_0000049
type: Parameter
constant: true
value: 4.76
name: e_Eno_Kpg3

metaid_0000374
type: Reaction
kinetic law: 786768
modifier: 786756
modifier: 786743
product: 786731
fast: false
reversible: false
name: env_growth

786731
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000210

metaid_0000338
type: Reaction
kinetic law: 785206
reactant: 785193
fast: false
reversible: false
name: d_CraFBP

785193
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000248

metaid_0000248
type: Species
constant: false
in compartment: metaid_0000209
has part: CHEBI:16905
initial amount: 0.006990902
initial concentration: NaN
boundary condition: false
is: SBO:0000253
has part: P0ACP1
name: CraFBP
has only substance units: true

metaid_0000115
type: Parameter
constant: true
value: 100.0
name: tf_PdhR_scale

metaid_0000200
type: Parameter
constant: false
value: 0.0
name: k_bm_AKG

metaid_0000372
type: Reaction
kinetic law: 786670
modifier: 786658
modifier: 786646
reactant: 786633
fast: false
reversible: false
name: d_PG3

786633
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000223

metaid_0000113
type: Parameter
constant: true
value: 0.895
name: tf_Crp_kcamp

metaid_0000289
type: Reaction
kinetic law: 782665
modifier: 782653
modifier: 782640
product: 782628
fast: false
reversible: false
name: e_Cya

782628
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000215

metaid_0000129
type: Parameter
constant: true
value: 1.0
name: g_aceBAK_DNA

metaid_0000287
type: Reaction
kinetic law: 782579
modifier: 782567
product: 782554
reactant: 782542
fast: false
reversible: false
name: e_Akg2mal

metaid_0000230
type: Species
is: SBO:0000014
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001026848
in compartment: metaid_0000209
name: Akg2mal

782554
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000220

782542
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000214

metaid_0000074
type: Parameter
constant: true
value: 6.54
name: e_Me_Kcamp

metaid_0000377
type: Reaction
kinetic law: 786949
modifier: 786901
modifier: 786913
product: 786889
name: env_ACTex
fast: false
reversible: false
modifier: 786937
modifier: 786925

786889
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000211

metaid_0000136
type: Parameter
constant: true
value: 0.0047
name: g_acs_Kcrp

metaid_0000175
type: Parameter
constant: true
value: 3.9E-7
name: g_pykF_vcra_unbound

metaid_0000072
type: Parameter
constant: true
value: 0.00624
name: e_Me_Kmal

533561
type: Parameter
constant: true
units: metaid_0001382
value: 8.15
name: shift1

metaid_0000088
type: Parameter
constant: true
value: 0.138
name: e_PfkA_Kpep

533577
type: Parameter
constant: true
value: 0.03
name: BM_1

metaid_0000173
type: Parameter
constant: true
value: 3.3E-6
name: g_ppsA_vcra_bound

metaid_0000025
type: Parameter
constant: true
value: 0.173
name: e_AceK_Koaa

metaid_0000350
type: Reaction
kinetic law: 785724
modifier: 785712
modifier: 785700
reactant: 785687
fast: false
reversible: false
name: d_Me

785687
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000240

metaid_0000189
type: Parameter
constant: true
value: 0.108
name: bm_ACT_ACoA

metaid_0000095
type: Parameter
constant: true
value: 2.0
name: e_PpsA_n

metaid_0000143
type: Parameter
constant: true
value: 0.09
name: g_emp_Kcra

metaid_0000107
type: Parameter
constant: true
value: 0.0085
name: pts_KEIIA

metaid_0000379
type: SBMLUnitsDef
unit: 781366
name: micromole

781366
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000364
type: Reaction
kinetic law: 786279
modifier: 786267
modifier: 786255
reactant: 786243
fast: false
reversible: false
name: d_cAMP

786243
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000215

metaid_0000141
type: Parameter
constant: true
value: 6.2E-7
name: g_emp_vcra_unbound

metaid_0000328
type: Reaction
kinetic law: 784830
product: 784818
fast: false
reversible: false
name: g_EIIA

784818
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000254

metaid_0000105
type: Parameter
constant: true
value: 46.3
name: pts_km1

metaid_0000311
type: Reaction
kinetic law: 783956
product: 783944
fast: false
reversible: false
name: g_crp

783944
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000249

metaid_0000353
type: Reaction
kinetic law: 785845
reactant: 785833
fast: false
reversible: false
name: d_PdhR

785833
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000252

metaid_0000206
type: Parameter
constant: false
value: 0.0
name: SS_Me

metaid_0000112
type: Parameter
constant: true
value: 1.0E8
name: tf_Crp_scale

metaid_0000066
type: Parameter
constant: true
value: 773.0
name: e_Mdh_kcat

metaid_0000369
type: Reaction
kinetic law: 786523
modifier: 786511
modifier: 786499
reactant: 786487
fast: false
reversible: false
name: d_MAL

786487
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000220

metaid_0000128
type: Parameter
constant: true
value: 9.3E-4
name: g_aceBAK_kcat_iclr

metaid_0000151
type: Parameter
constant: true
value: 4.5E-8
name: g_fdp_vcra_bound

metaid_0000271
type: Reaction
kinetic law: 781572
modifier: 781559
modifier: 781547
reactant: 781535
fast: false
reversible: false
name: bm_G6P

781535
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000217

metaid_0000167
type: Parameter
constant: true
value: 1.3E-9
name: g_pdh_vpdhr_bound

metaid_0000064
type: Parameter
constant: true
value: 1.6E-4
name: e_Icd_Kict

metaid_0000367
type: Reaction
kinetic law: 786424
modifier: 786412
modifier: 786399
reactant: 786387
fast: false
reversible: false
name: d_GLX

786387
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000218

metaid_0000126
type: Parameter
constant: true
value: 0.00488
name: g_aceBAK_KG

metaid_0000165
type: Parameter
constant: true
value: 0.00535
name: g_pckA_Kcra

metaid_0000071
type: Parameter
constant: true
value: 104000.0
name: e_Me_L

metaid_0000276
type: Reaction
is version of: GO:0006468
reversible: true
name: pts_r1
reactant: 781792
product: 781804
product: 781816
kinetic law: 781828
reactant: 781780
is part of: GO:0009401
fast: false

781792
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000254

781804
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000224

781816
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000255

781780
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

metaid_0000087
type: Parameter
constant: true
value: 0.022
name: e_PfkA_Kg6p

metaid_0000172
type: Parameter
constant: true
value: 0.0
name: g_ppsA_vcra_unbound

metaid_0000340
type: Reaction
kinetic law: 785259
reactant: 785246
fast: false
reversible: false
name: d_CrpcAMP

785246
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000250

metaid_0000038
type: Parameter
constant: true
value: 0.548
name: e_Akg2mal_Kakg

metaid_0000274
type: Reaction
kinetic law: 781719
modifier: 781707
modifier: 781695
reactant: 781682
fast: false
reversible: false
name: bm_PG3

781682
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000223

metaid_0000188
type: Parameter
constant: true
value: 0.553
name: bm_GLC_PYR

metaid_0000085
type: Parameter
constant: true
value: 4.0
name: e_PfkA_n

metaid_0000133
type: Parameter
constant: true
value: 0.0
name: g_acs_vcrp_unbound

533574
type: Parameter
constant: true
units: metaid_0020382
value: 3.0
name: ACT_2

metaid_0000170
type: Parameter
constant: true
value: 6.6E-9
name: g_pfkA_vcra_bound

metaid_0000186
type: Parameter
constant: true
value: 0.423
name: bm_GLC_PEP

metaid_0000190
type: Parameter
constant: true
value: 0.056
name: bm_ACT_AKG

metaid_0000382
type: SBMLUnitsDef
unit: 781391
name: seconds

781391
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND

metaid_0000140
type: Parameter
constant: true
value: 0.74
name: g_akg2mal_n

metaid_0000345
type: Reaction
kinetic law: 785493
modifier: 785480
modifier: 785467
reactant: 785454
fast: false
reversible: false
name: d_GltA

785454
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000236

metaid_0000236
type: Species
initial concentration: NaN
is: SBO:0000014
constant: false
boundary condition: false
is version of: P0ABH7
initial amount: 0.001029612
name: GltA
has only substance units: true
in compartment: metaid_0000209

metaid_0000104
type: Parameter
constant: true
value: 116.0
name: pts_k1

metaid_0000006
type: Parameter
constant: true
value: 614.0
name: e_AceA_kcat

metaid_0000280
type: Reaction
kinetic law: 782191
modifier: 782179
product: 782167
reactant: 782155
is version of: GO:0043234
fast: false
reversible: true
name: tf_Cra

782167
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000248

782155
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000247

metaid_0000310
type: Reaction
kinetic law: 783932
product: 783920
fast: false
reversible: false
name: g_cra

783920
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000247

metaid_0000343
type: Reaction
kinetic law: 785389
modifier: 785376
modifier: 785363
reactant: 785350
fast: false
reversible: false
name: d_Eno

785350
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000234

metaid_0000205
type: Parameter
constant: false
value: 0.0
name: k_bm_PYR

metaid_0000102
type: Parameter
constant: true
value: 5.0
name: e_PykF_Kpep

metaid_0000004
type: Parameter
constant: true
value: 180.156
name: env_M_GLC

metaid_0000092
type: Parameter
constant: true
value: 0.048
name: e_Ppc_Kpep

metaid_0000359
type: Reaction
kinetic law: 786085
reactant: 786073
fast: false
reversible: false
name: d_EIIA

786073
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000254

metaid_0000118
type: Parameter
constant: true
value: 1.9E-9
name: g_aceBAK_vcra_unbound

metaid_0000203
type: Parameter
constant: false
value: 0.0
name: k_bm_PEP

metaid_0000294
type: Reaction
kinetic law: 782955
modifier: 782943
modifier: 782931
product: 782919
reactant: 782907
fast: false
reversible: false
name: e_Icd

782919
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000214

782907
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000219

metaid_0000157
type: Parameter
constant: true
value: 1.1E-7
name: g_icd_vcra_unbound

metaid_0000063
type: Parameter
constant: true
value: 127.0
name: e_Icd_L

metaid_0000366
type: Reaction
kinetic law: 786375
modifier: 786363
modifier: 786351
reactant: 786339
fast: false
reversible: false
name: d_G6P

786339
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000217

metaid_0000050
type: Parameter
constant: true
value: 1.11
name: e_Eno_Kpep

metaid_0000079
type: Parameter
constant: true
value: 2.65
name: e_Pdh_n

metaid_0000014
type: Parameter
constant: true
value: 0.95
name: e_AceB_Kglx

metaid_0000380
type: SBMLUnitsDef
unit: 781378
name: volume

781378
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

metaid_0000164
type: Parameter
constant: true
value: 2.5E-6
name: g_pckA_vcra_bound

metaid_0000061
type: Parameter
constant: true
value: 695.0
name: e_Icd_kcat

metaid_0000313
type: Reaction
fast: false
kinetic law: 784052
name: g_emp
modifier: 784004
reversible: false
modifier: 784016
product: 783992
modifier: 784028
modifier: 784040

783992
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000233

metaid_0000077
type: Parameter
constant: true
value: 1000.0
name: e_PckA_Kpep

metaid_0000162
type: Parameter
constant: true
value: 0.06
name: g_mdh_Kcrp

metaid_0000321
type: Reaction
kinetic law: 784491
modifier: 784478
modifier: 784466
modifier: 784454
product: 784441
fast: false
reversible: false
name: g_pckA

784441
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000241

metaid_0000028
type: Parameter
constant: true
value: 1.57
name: e_AceK_Kpg3

metaid_0000273
type: Reaction
kinetic law: 781670
modifier: 781657
modifier: 781644
reactant: 781632
fast: false
reversible: false
name: bm_PEP

781632
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

metaid_0000178
type: Parameter
constant: true
value: 2.8E-5
name: d_k_degr

metaid_0000132
type: Parameter
constant: true
value: 0.341
name: g_aceBAK_Kcrp

metaid_0000130
type: Parameter
constant: true
value: 2.3E-10
name: g_aceBAK_vcrp_bound

metaid_0000335
type: Reaction
kinetic law: 785128
modifier: 785115
modifier: 785102
reactant: 785089
fast: false
reversible: false
name: d_Akg2mal

785089
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000230

metaid_0000146
type: Parameter
constant: true
value: 0.012
name: g_emp_Kcrp

metaid_0000300
type: Reaction
kinetic law: 783305
modifier: 783293
modifier: 783281
product: 783269
reactant: 783257
fast: false
reversible: false
name: e_Ppc

783269
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000221

783257
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

metaid_0000342
type: Reaction
kinetic law: 785337
modifier: 785324
modifier: 785311
reactant: 785298
fast: false
reversible: false
name: d_Emp

785298
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000233

metaid_0000003
type: Parameter
constant: true
value: 60.05
name: env_M_ACT

metaid_0000358
type: Reaction
kinetic law: 786061
modifier: 786049
modifier: 786037
reactant: 786025
fast: false
reversible: false
name: d_PykF

786025
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000246

metaid_0000042
type: Parameter
constant: true
value: 0.0017
name: e_Cya_KEIIA

metaid_0000293
type: Reaction
reactant: 782834
name: e_GltA
modifier: 782883
modifier: 782871
reversible: false
fast: false
kinetic law: 782895
product: 782859
reactant: 782847

782834
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000213

782859
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000219

782847
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000221

metaid_0000156
type: Parameter
constant: true
value: 1.07
name: g_gltA_n

metaid_0000058
type: Parameter
constant: true
value: 0.212
name: e_GltA_Kacoa

metaid_0000305
type: Reaction
name: g_aceK
modifier: 783680
reversible: false
fast: false
modifier: 783704
product: 783644
modifier: 783692
kinetic law: 783740
modifier: 783668
modifier: 783656
modifier: 783716
modifier: 783728

783644
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000227

metaid_0000356
type: Reaction
kinetic law: 785965
modifier: 785953
modifier: 785941
reactant: 785929
fast: false
reversible: false
name: d_Ppc

785929
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000244

metaid_0000040
type: Parameter
constant: true
value: 0.1
name: e_CAMPdegr_KcAMP

metaid_0000069
type: Parameter
constant: true
value: 1879.0
name: e_Me_kcat

metaid_0000291
type: Reaction
kinetic law: 782762
modifier: 782750
product: 782738
reactant: 782726
fast: false
reversible: true
name: e_Eno

782738
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

782726
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000223

metaid_0000154
type: Parameter
constant: true
value: 2.3E-6
name: g_gltA_vcrp_bound

metaid_0000056
type: Parameter
constant: true
value: 1614.0
name: e_GltA_kcat

metaid_0000303
type: Reaction
product: 783426
modifier: 783474
modifier: 783510
name: g_aceA
reversible: false
modifier: 783498
fast: false
kinetic law: 783522
modifier: 783462
modifier: 783438
modifier: 783486
modifier: 783450

783426
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000225

metaid_0000010
type: Parameter
constant: true
value: 0.055
name: e_AceA_Kpep

metaid_0000319
type: Reaction
kinetic law: 784379
modifier: 784366
modifier: 784354
modifier: 784342
product: 784330
fast: false
reversible: false
name: g_mdh

784330
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000239

metaid_0000027
type: Parameter
constant: true
value: 0.82
name: e_AceK_Kakg

metaid_0000296
type: Reaction
reactant: 783016
product: 783028
name: e_Me
modifier: 783064
reversible: false
modifier: 783040
kinetic law: 783076
modifier: 783052
fast: false

783016
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000220

783028
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000224

metaid_0000122
type: Parameter
constant: true
value: 0.03
name: g_aceBAK_aceKfactor

metaid_0000279
type: Reaction
fast: false
modifier: 782131
modifier: 782119
modifier: 782071
modifier: 782095
modifier: 782083
kinetic law: 782143
name: e_AceK_Ph
product: 782059
is version of: GO:0006470
modifier: 782107
reactant: 782047
reversible: false

782059
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000237

782047
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000238

metaid_0000081
type: Parameter
constant: true
value: 0.128
name: e_Pdh_Kpyr

metaid_0000334
type: Reaction
kinetic law: 785076
modifier: 785063
modifier: 785051
reactant: 785039
fast: false
reversible: false
name: d_Acs

785039
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000229

metaid_0000195
type: Parameter
constant: true
value: 5.185
name: bm_ACT_PYR

metaid_0000034
type: Parameter
constant: true
value: 0.022
name: e_Acoa2act_Kpyr

metaid_0000332
type: Reaction
kinetic law: 785001
modifier: 784989
modifier: 784977
reactant: 784964
fast: false
reversible: false
name: d_AceK

784964
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000227

metaid_0000193
type: Parameter
constant: true
value: 0.047
name: bm_ACT_PEP

metaid_0000348
type: Reaction
kinetic law: 785623
reactant: 785610
fast: false
reversible: false
name: d_IclR

785610
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000251

metaid_0000009
type: Parameter
constant: true
value: 0.022
name: e_AceA_Kict

metaid_0000180
type: Parameter
constant: true
value: 5.6E-5
name: bm_muACT

metaid_0000032
type: Parameter
constant: true
value: 639000.0
name: e_Acoa2act_L

metaid_0000283
type: Reaction
kinetic law: 782374
product: 782326
modifier: 782362
product: 782314
modifier: 782338
is part of: R00267
modifier: 782350
reactant: 782301
name: e_AceA
is part of: R00479
reversible: false
fast: false

782326
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000218

782314
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000214

782301
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000219

metaid_0000048
type: Parameter
constant: true
value: 522.0
name: e_Eno_kcatr

metaid_0000373
type: Reaction
kinetic law: 786719
modifier: 786706
modifier: 786694
reactant: 786682
fast: false
reversible: false
name: d_PYR

786682
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000224

metaid_0000337
type: Reaction
kinetic law: 785180
reactant: 785167
fast: false
reversible: false
name: d_Cra

785167
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000247

metaid_0000055
type: Parameter
constant: true
value: 0.3
name: e_Fdp_Kpep

metaid_0000371
type: Reaction
kinetic law: 786621
modifier: 786609
modifier: 786597
reactant: 786584
fast: false
reversible: false
name: d_PEP

786584
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

metaid_0000302
type: Reaction
kinetic law: 783414
modifier: 783402
modifier: 783390
product: 783378
reactant: 783366
fast: false
reversible: false
name: e_PykF

783378
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000224

783366
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000222

metaid_0000019
type: Parameter
constant: true
value: 2.0
name: e_AceK_n

metaid_0000288
type: Reaction
kinetic law: 782616
modifier: 782603
reactant: 782591
fast: false
reversible: false
name: e_CAMPdegr

782591
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000215

metaid_0000318
type: Reaction
kinetic law: 784318
product: 784306
fast: false
reversible: false
name: g_iclr

784306
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000251

metaid_0000053
type: Parameter
constant: true
value: 4000000.0
name: e_Fdp_L

metaid_0000017
type: Parameter
constant: true
value: 3.4E12
name: e_AceK_kcat_ki

metaid_0000286
type: Reaction
kinetic law: 782530
modifier: 782518
modifier: 782506
product: 782494
fast: false
reversible: false
name: e_Acs

782494
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000213

metaid_0000316
type: Reaction
kinetic law: 784233
modifier: 784221
modifier: 784209
modifier: 784197
product: 784185
fast: false
reversible: false
name: g_gltA

784185
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000236

metaid_0000135
type: Parameter
constant: true
value: 2.31
name: g_acs_n

metaid_0000324
type: Reaction
kinetic law: 784636
modifier: 784624
modifier: 784612
modifier: 784600
product: 784588
fast: false
reversible: false
name: g_pfkA

784588
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000243

metaid_0000024
type: Parameter
constant: true
value: 0.038
name: e_AceK_Kpyr

metaid_0000094
type: Parameter
constant: true
value: 1.32
name: e_PpsA_kcat

metaid_0000192
type: Parameter
constant: true
value: 1.43
name: bm_ACT_OAA

metaid_0000329
type: Reaction
kinetic law: 784854
product: 784842
fast: false
reversible: false
name: g_EIICB

784842
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000256

metaid_0000031
type: Parameter
constant: true
value: 2.0
name: e_Acoa2act_n

metaid_0000047
type: Parameter
constant: true
value: 695.0
name: e_Eno_kcatf

metaid_0000363
type: Reaction
kinetic law: 786231
modifier: 786219
modifier: 786207
reactant: 786195
fast: false
reversible: false
name: d_AKG

786195
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000214

metaid_0000159
type: Parameter
constant: true
value: 0.00117
name: g_icd_Kcra

metaid_0000327
type: Reaction
kinetic law: 784806
modifier: 784794
modifier: 784782
modifier: 784770
product: 784758
fast: false
reversible: false
name: g_pykF

784758
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000246

metaid_0000045
type: Parameter
constant: true
value: 5.92
name: e_Emp_Kfbp

metaid_0000370
type: Reaction
kinetic law: 786572
modifier: 786560
modifier: 786548
reactant: 786535
fast: false
reversible: false
name: d_OAA

786535
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000221

metaid_0000111
type: Parameter
constant: true
value: 2.0
name: tf_Cra_n

metaid_0000308
type: Reaction
kinetic law: 783884
modifier: 783872
modifier: 783860
modifier: 783848
product: 783836
fast: false
reversible: false
name: g_akg2mal

783836
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000230

metaid_0000127
type: Parameter
constant: true
value: 923.0
name: g_aceBAK_L

metaid_0000270
type: Reaction
kinetic law: 781523
modifier: 781511
modifier: 781499
reactant: 781487
fast: false
reversible: false
name: bm_AKG

781487
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000214

metaid_0000285
type: Reaction
kinetic law: 782482
modifier: 782470
modifier: 782458
reactant: 782446
is version of: R00227
fast: false
reversible: false
name: e_Acoa2act

782446
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000213

metaid_0000013
type: Parameter
constant: true
value: 47.8
name: e_AceB_kcat

metaid_0000125
type: Parameter
constant: true
value: 0.00301
name: g_aceBAK_KPprime

metaid_0000070
type: Parameter
constant: true
value: 1.33
name: e_Me_n

metaid_0000299
type: Reaction
kinetic law: 783245
modifier: 783233
modifier: 783221
product: 783209
reactant: 783197
fast: false
reversible: false
name: e_PfkA

783209
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000216

783197
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000217

metaid_0000086
type: Parameter
constant: true
value: 9.5E7
name: e_PfkA_L

metaid_0000171
type: Parameter
constant: true
value: 6.3E-7
name: g_pfkA_Kcra

metaid_0000023
type: Parameter
constant: true
value: 0.539
name: e_AceK_Kpep

metaid_0000187
type: Parameter
constant: true
value: 0.049
name: bm_GLC_PG3

metaid_0000084
type: Parameter
constant: true
value: 908000.0
name: e_PfkA_kcat

metaid_0000021
type: Parameter
constant: true
value: 0.043
name: e_AceK_Kicd

metaid_0000198
type: Parameter
constant: false
value: 0.0
name: mu

metaid_0000185
type: Parameter
constant: true
value: 6.4
name: bm_GLC_OAA

metaid_0000037
type: Parameter
constant: true
value: 1530.0
name: e_Akg2mal_kcat

metaid_0000362
type: Reaction
kinetic law: 786182
modifier: 786170
modifier: 786158
reactant: 786146
fast: false
reversible: false
name: d_ACoA

786146
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000213

metaid_0000149
type: Parameter
constant: true
value: 0.016
name: g_eno_Kcra

metaid_0000326
type: Reaction
kinetic law: 784746
modifier: 784734
modifier: 784721
modifier: 784709
product: 784697
fast: false
reversible: false
name: g_ppsA

784697
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000245

metaid_0000103
type: Parameter
constant: true
value: 0.413
name: e_PykF_Kfbp

533571
type: Parameter
constant: true
units: metaid_0020382
value: 5.0
name: ACT_1

533426
type: Event
event assignment: 787045
event assignment: 787033
event assignment: 787021
trigger: 787009
use values from trigger time: true
name: second shift

787009
type: Trigger
persistant: true
initial value: true

metaid_0000119
type: Parameter
constant: true
value: 2.0E-6
name: g_aceBAK_vcra_bound

metaid_0000360
type: Reaction
kinetic law: 786109
reactant: 786097
fast: false
reversible: false
name: d_EIIA_P

786097
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000255

metaid_0000204
type: Parameter
constant: false
value: 0.0
name: k_bm_PG3

metaid_0000101
type: Parameter
constant: true
value: 100000.0
name: e_PykF_L

W3 CDTF: Sun Mar 14 23:34:51 GMT 2010

W3 CDTF: Thu Sep 08 13:36:40 BST 2011