BIOMD0000000238
type: SBMLModel
parameter: 157031
is described by: http://identifiers.org/pubmed/17009101
parameter: 157027
parameter: 156997
parameter: 157007
parameter: 157009
parameter: 156943
rule: 156949
parameter: 157015
parameter: 156985
parameter: 157001
name: Overgaard2007_PDmodel_IL21
notes: This a model from the article: PKPD model of interleukin-21 effects on thermoregulation in monkeys--application and evaluation of stochastic differential equations. Overgaard RV, Holford N, Rytved KA, Madsen H. Pharm Res. 2007 Feb;24(2):298-309. PUBMED , Abstract: PURPOSE: To describe the pharmacodynamic effects of recombinant human interleukin-21 (IL-21) on core body temperature in cynomolgus monkeys using basic mechanisms of heat regulation. A major effort was devoted to compare the use of ordinary differential equations (ODEs) with stochastic differential equations (SDEs) in pharmacokinetic pharmacodynamic (PKPD) modelling. METHODS: A temperature model was formulated including circadian rhythm, metabolism, heat loss, and a thermoregulatory set-point. This model was formulated as a mixed-effects model based on SDEs using NONMEM. RESULTS: The effects of IL-21 were on the set-point and the circadian rhythm of metabolism. The model was able to describe a complex set of IL-21 induced phenomena, including 1) disappearance of the circadian rhythm, 2) no effect after first dose, and 3) high variability after second dose. SDEs provided a more realistic description with improved simulation properties, and further changed the model into one that could not be falsified by the autocorrelation function. CONCLUSIONS: The IL-21 induced effects on thermoregulation in cynomolgus monkeys are explained by a biologically plausible model. The quality of the model was improved by the use of SDEs. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellula…
rule: 156970
rule: 156962
parameter: 157030
parameter: 156994
parameter: 157034
is: MODEL0911110000
rule: 156974
parameter: 157029
parameter: 157042
parameter: 157022
parameter: 157038
parameter: 157041
rule: 156957
parameter: 157017
is version of: GO:0060086
parameter: 157045
parameter: 157011
rule: 156969
rule: 156956
is version of: GO:0001659
parameter: 156939
parameter: 156940
length unit: length
rule: 156951
substance units: metaid_0000028
rule: 156960
parameter: 157026
parameter: 157006
rule: 156972
rule: 156977
curated: true
parameter: 157033
compartment: 156933
parameter: 157049
rule: 156964
parameter: 156999
parameter: 157014
parameter: 157021
parameter: 157037
rule: 156976
parameter: 156987
parameter: 156989
parameter: 156993
parameter: 157003
occurs in: http://identifiers.org/taxonomy/9541
parameter: 157050
is version of: http://identifiers.org/omim/605384
rule: 156980
rule: 156958
area units: metaid_0000005
rule: 156961
parameter: 157010
parameter: 157039
parameter: 157019
rule: 156953
parameter: 157047
parameter: 157025
parameter: 156995
volume units: metaid_0000004
parameter: 156941
parameter: 156936
time units: metaid_0000029
rule: 156965
parameter: 157013
parameter: 156998
rule: 156952

157031
type: Parameter
constant: false
value: NaN
name: gNsTs1

157027
type: Parameter
constant: true
value: 0.2229166
name: alpha

156997
type: Parameter
constant: true
value: 6.73
name: t_night

157007
type: Parameter
constant: true
value: 3.0
name: AMT_dose

157009
type: Parameter
constant: true
value: 1.0
name: pEf1

156943
type: Parameter
constant: false
value: NaN
name: Priming

157015
type: Parameter
constant: true
value: 50.0
name: pEs3

156985
type: Parameter
constant: true
value: 21.0
name: ambient temperature

157001
type: Parameter
constant: true
value: 1.1375
name: rate constant Metabolism

157030
type: Parameter
constant: false
value: NaN
name: M_night_baseline

156994
type: Parameter
constant: false
value: NaN
name: circadian rhythm

157034
type: Parameter
constant: false
value: NaN
name: gNsTs3

157029
type: Parameter
constant: true
value: 1.0
name: delta_high_dose

157042
type: Parameter
constant: true
value: 2.45
name: mean total delay (slow)

157022
type: Parameter
constant: true
value: 3.0
name: M_b

157038
type: Parameter
constant: false
value: NaN
name: gNfTf3

157041
type: Parameter
constant: true
value: 4.0
name: No. of transit compartment (fast)

157017
type: Parameter
constant: false
value: NaN
name: f2_drug

157045
type: Parameter
constant: false
value: NaN
name: X1

157011
type: Parameter
constant: true
value: 3.57
name: pEf2

156939
type: Parameter
constant: false
value: 0.0
name: Bound Receptor

156940
type: Parameter
constant: false
value: NaN
name: Slow Effect

157026
type: Parameter
constant: true
value: 45.12
name: t_prime

157006
type: Parameter
constant: true
value: 5.35
name: kR

157033
type: Parameter
constant: false
value: NaN
name: gNsTs2

156933
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0

157049
type: Parameter
constant: false
value: NaN
name: Kf

156999
type: Parameter
constant: true
value: 86400.0
name: day_length

157014
type: Parameter
constant: true
value: 8.0
name: pEf3

157021
type: Parameter
constant: false
value: NaN
name: heat conductance baselinevalue

157037
type: Parameter
constant: false
value: NaN
name: gNfTf2

156987
type: Parameter
constant: true
value: 1.57
name: temperature difference

156989
type: Parameter
constant: true
value: 0.0258
name: kinc

156993
type: Parameter
constant: true
value: 120.0
name: tdose3

157003
type: Parameter
constant: false
value: NaN
name: heat conductance

157050
type: Parameter
constant: false
value: NaN
name: Ks

157010
type: Parameter
constant: true
value: 0.2
name: pEs1

157039
type: Parameter
constant: true
value: 4.0
name: No. of transit compartment (slow)

157019
type: Parameter
constant: false
value: NaN
name: T_night

157047
type: Parameter
constant: false
value: NaN
name: X3

157025
type: Parameter
constant: false
value: NaN
name: M_night

156995
type: Parameter
constant: true
value: 17.5
name: t_day

156941
type: Parameter
constant: false
value: NaN
name: Fast Effect

156936
type: Parameter
constant: false
value: 3.5
name: Metabolic rate

157013
type: Parameter
constant: true
value: 2.43
name: pEs2

156998
type: Parameter
constant: false
value: NaN
name: tprime

156991
type: Parameter
constant: true
value: 72.0
name: tdose2

156986
type: Parameter
constant: true
value: 38.0
name: basiline temperature

ORG:
  orgname: Novo Nordisk A/S, Copenhagen, Denmark.
n:
  given: Rune Viig
  family: Overgaard

157035
type: Parameter
constant: false
value: NaN
name: gNfTf1

157002
type: Parameter
constant: true
value: 3.47
name: specific heat constant

157043
type: Parameter
constant: true
value: 0.368
name: mena total delay (fast)

157023
type: Parameter
constant: false
value: NaN
name: M_day

157005
type: Parameter
constant: true
value: 0.144
name: pEtot

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

156937
type: Parameter
constant: false
value: 38.785
name: Temperature

156990
type: Parameter
constant: true
value: 24.0
name: tdose1

157018
type: Parameter
constant: false
value: NaN
name: T_day

157046
type: Parameter
constant: false
value: NaN
name: X2

W3 CDTF: Thu Feb 11 13:35:13 GMT 2010

W3 CDTF: Thu Nov 12 14:29:18 GMT 2009

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah