BIOMD0000000232
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parameter: 304779
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species: metaid ADP
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parameter: 304782
reaction: 304703
parameter: 304788
substance units: 094936
reaction: 304709
reaction: 304730
is: MODEL2594602728
parameter: 304776
occurs in: http://identifiers.org/taxonomy/9606
parameter: 304821
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parameter: 304800
parameter: 304806
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parameter: 304833
units def: 095384
parameter: 304812
species: metaid OAA
parameter: 304818
is part of: REACT 2124
parameter: 304836
species: metaid NADH
species: metaid He
compartment: metaid mitochondrion
parameter: 304773
rule: 304747
species: metaid H2O
species: metaid iP
area units: metaid_0000005
reaction: 304721
is described by: http://identifiers.org/pubmed/19007794
initial assignment: BIOMD0000000232#
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has version: GO:0070469
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species: metaid Cit
parameter: 304797
reaction: 304712
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parameter: 304830
species: metaid AcCoA
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compartment: metaid cytoplasm
name: Nazaret2009_TCA_RC_ATP
parameter: 304803
volume units: metaid_0000004
units def: 095433
species: metaid H
curated: true
species: metaid KG
rule: 304756
reaction: 304727
notes: This a model from the article: Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production. Nazaret C, Heiske M, Thurley K, Mazat JP J. Theor. Biol. 2009 Jun;258(3):455-64 19007794 , Abstract: Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.
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reaction: 304718
species: metaid Pyr
species: metaid O2
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metaid mitochondrion
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304782
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304703
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304731
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095166
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095493
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304788
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304709
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is version of: CHEBI:16908

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304737
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095732
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initial concentration: 0.856
is version of: C00003
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name: NAD(+)
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is version of: CHEBI:15846

304730
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reactant: 096095
is: SBO:0000185
fast: false
reversible: false
name: vleak

096107
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096095
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metaid cytoplasm
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304776
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095082
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304821
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095433
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name: per millivolt

095445
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304794
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304800
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304806
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value: 2.0

094960
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name: coulomb per mole

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094972
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multipler: 1.0
kind: COULOMB

304833
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constant: true
units: 095214
value: 4.26E-4

095214
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unit: 095250
unit: 095238
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304812
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constant: true
units: 095082
value: 1.07

304818
type: Parameter
constant: true
units: kelvin
value: 298.0
name: absolute temperature

304836
type: Parameter
constant: true
units: 095166
value: 2.5

304773
type: Parameter
constant: false
units: 095082
value: NaN

metaid H2O
type: Species
name: water
has only substance units: false
initial amount: NaN
is: SBO:0000247
is version of: CHEBI:15377
initial concentration: 1.0
is version of: C00001
boundary condition: true
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constant: true

metaid iP
type: Species
constant: true
boundary condition: true
in compartment: metaid mitochondrion
is version of: CHEBI:18367
initial amount: NaN
name: phosphate
initial concentration: 2.44
is version of: C00009
has only substance units: false
is: SBO:0000327

304721
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is version of: R07171
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fast: false
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095913
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095901
type: SpeciesReference
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species: metaid O2

metaid O2
type: Species
name: oxygen
initial amount: NaN
boundary condition: true
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constant: true
is version of: C00007
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095949
type: SpeciesReference
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095925
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095888
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095937
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species: metaid H2O

304785
type: Parameter
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304706
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304735
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units: 095336
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095637
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species: metaid NAD

095660
type: SpeciesReference
stoichiometry: 1.0
species: metaid NADH

095625
type: SpeciesReference
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species: metaid Cit

metaid Cit
type: Species
in compartment: metaid mitochondrion
is: SBO:0000247
has only substance units: false
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is version of: C00158
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name: citrate
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095648
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304797
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304712
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name: v6

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304738
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095457
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304824
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value: 0.004

304830
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value: 131.9

metaid AcCoA
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name: acetyl-CoA
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initial concentration: 0.063
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304727
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096071
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304704
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304733
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304705
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304734
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value: 57.142

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304742
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value: 3.6

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304791
type: Parameter
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units: 094960
value: 96485.0
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304724
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name: vATP
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095985
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096021
type: SpeciesReference
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species: metaid H2O

W3 CDTF: Thu Sep 10 01:00:00 BST 2009

304827
type: Parameter
constant: true
units: 095457
value: 0.05387

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

W3 CDTF: Fri Jan 22 15:30:56 GMT 2010