BIOMD0000000220
type: SBMLModel
parameter: metaid_0000062
reaction: metaid_0000154
species: metaid_0000116
reaction: metaid_0000147
reaction: metaid_0000149
area units: metaid_0000005
parameter: metaid_0000056
parameter: metaid_0000007
species: metaid_0000104
species: metaid_0000131
reaction: metaid_0000159
parameter: metaid_0000072
reaction: metaid_0000143
species: metaid_0000094
rule: metaid_0000186
species: metaid_0000124
reaction: metaid_0000161
parameter: metaid_0000052
is version of: hsa04210
name: Albeck2008_extrinsic_apoptosis
reaction: metaid_0000155
parameter: metaid_0000057
species: metaid_0000086
species: metaid_0000130
species: metaid_0000112
parameter: metaid_0000073
reaction: metaid_0000173
species: metaid_0000093
species: metaid_0000079
parameter: metaid_0000069
rule: metaid_0000181
species: metaid_0000080
parameter: metaid_0000053
parameter: metaid_0000048
species: metaid_0000100
reaction: metaid_0000156
is version of: REACT 1059
species: metaid_0000085
reaction: metaid_0000174
parameter: metaid_0000065
volume units: metaid_0000069
parameter: metaid_0000044
parameter: metaid_0000177
parameter: metaid_0000058
species: metaid_0000106
reaction: metaid_0000166
parameter: metaid_0000024
reaction: metaid_0000170
parameter: metaid_0000061
compartment: metaid_0000188
parameter: metaid_0000040
reaction: metaid_0000163
parameter: metaid_0000054
reaction: metaid_0000146
reaction: metaid_0000150
parameter: metaid_0000178
time units: 809101
parameter: metaid_0000059
parameter: metaid_0000070
parameter: metaid_0000020
reaction: metaid_0000142
parameter: metaid_0000050
species: metaid_0000189
species: metaid_0000129
species: metaid_0000082
species: metaid_0000076
parameter: metaid_0000055
species: metaid_0000120
parameter: metaid_0000071
reaction: metaid_0000137
reaction: metaid_0000171
species: metaid_0000087
parameter: metaid_0000067
parameter: metaid_0000051
parameter: metaid_0000046
reaction: metaid_0000151
parameter: metaid_0000184
is: MODEL6964793701
parameter: metaid_0000028

metaid_0000062
type: Parameter
constant: true
value: 0.001
name: k_24

metaid_0000154
type: Reaction
kinetic law: 743013
product: 743001
reactant: 742989
reactant: 742977
fast: false
reversible: true

743001
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

metaid_0000111
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Smac:XIAP

metaid_0000074
type: Compartment
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

742989
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000091
type: Species
is version of: Q9NR28
boundary condition: false
in compartment: metaid_0000074
has only substance units: false
initial concentration: NaN
is version of: REACT 5375
initial amount: 0.0
name: Smac
constant: false

742977
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

metaid_0000087
type: Species
initial concentration: NaN
is version of: P98170
constant: false
has only substance units: false
boundary condition: false
initial amount: 100000.0
name: XIAP
is version of: REACT 5246
in compartment: metaid_0000074

metaid_0000116
type: Species
has only substance units: false
boundary condition: false
name: Bax2:Bcl2
has part: P10415
initial amount: 0.0
in compartment: metaid_0000188
has part: Q07812
constant: false
initial concentration: NaN

metaid_0000188
type: Compartment
is: GO:0005739
constant: true
size: 1.0
spatial dimensions: 3.0
name: mitochondrion

metaid_0000147
type: Reaction
kinetic law: 742676
product: 742664
reactant: 742652
reactant: 742640
fast: false
reversible: true

742664
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

metaid_0000107
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C3:pC6

742652
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000086

metaid_0000086
type: Species
is version of: P55212
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10000.0
in compartment: metaid_0000074
name: proC6

742640
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

metaid_0000083
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: casp3

metaid_0000149
type: Reaction
kinetic law: 742772
product: 742760
reactant: 742748
reactant: 742736
fast: false
reversible: true

742760
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000108

metaid_0000108
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: XIAP:C3

742748
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

742736
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

metaid_0000056
type: Parameter
constant: true
value: 0.01
name: k22

metaid_0000007
type: Parameter
constant: true
value: 0.001
name: k_2

metaid_0000104
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: pC3:Apop

metaid_0000131
type: Species
is version of: P55211
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
in compartment: metaid_0000074
name: proC9

metaid_0000159
type: Reaction
kinetic law: 743243
product: 743231
reactant: 743219
reactant: 743207
fast: false
reversible: true

743231
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

metaid_0000114
type: Species
has only substance units: false
name: Baxm:Bcl2
boundary condition: false
has part: P10415
in compartment: metaid_0000188
has part: Q07812
initial amount: 0.0
initial concentration: NaN
constant: false

743219
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000096

metaid_0000096
type: Species
has only substance units: false
initial amount: 20000.0
constant: false
notes: mitochondrial Bcl-2
is version of: P10415
in compartment: metaid_0000188
name: Bcl-2
boundary condition: false
initial concentration: NaN

743207
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000189

metaid_0000189
type: Species
is version of: Q07812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: Baxm

metaid_0000072
type: Parameter
constant: true
value: 1.0
name: kc7

metaid_0000143
type: Reaction
kinetic law: 742484
product: 742472
reactant: 742460
reactant: 742448
fast: false
reversible: true

742472
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000106

metaid_0000106
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C8:Bid

742460
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000084

metaid_0000084
type: Species
initial amount: 40000.0
in compartment: metaid_0000074
boundary condition: false
is version of: P55957
name: Bid
is described by: http://identifiers.org/omim/601997
initial concentration: NaN
has only substance units: false
is version of: REACT 3224
constant: false

742448
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

metaid_0000079
type: Species
is version of: REACT 4185
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: casp8

metaid_0000094
type: Species
in compartment: metaid_0000074
initial amount: 0.0
has only substance units: false
constant: false
boundary condition: false
initial concentration: NaN
notes: activated Bax
is version of: Q07812
name: Bax#

metaid_0000124
type: Species
in compartment: metaid_0000188
boundary condition: false
name: CytoC_m
initial amount: 500000.0
is version of: REACT_14114
is version of: P99999
constant: false
has only substance units: false
initial concentration: NaN

metaid_0000161
type: Reaction
kinetic law: 743339
product: 743327
reactant: 743315
reactant: 743303
fast: false
reversible: true

743327
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000115
type: Species
has only substance units: false
initial concentration: NaN
name: Bax4
has part: Q07812
initial amount: 0.0
notes: Bax tetramer
boundary condition: false
constant: false
in compartment: metaid_0000188

743315
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000190

metaid_0000190
type: Species
initial concentration: NaN
constant: false
name: Bax2
has only substance units: false
boundary condition: false
has part: Q07812
in compartment: metaid_0000188
initial amount: 0.0
notes: dimeric Bax

743303
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000190

metaid_0000052
type: Parameter
constant: true
value: 10.0
name: kc20

metaid_0000155
type: Reaction
kinetic law: 743061
product: 743049
reactant: 743037
reactant: 743025
fast: false
reversible: true

743049
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000112

metaid_0000112
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Bcl2c:tBid

743037
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000092

metaid_0000092
type: Species
has only substance units: false
in compartment: metaid_0000074
boundary condition: false
is version of: REACT 3598
initial concentration: NaN
constant: false
is version of: P10415
name: cytosolic Bcl-2
initial amount: 20000.0

743025
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

metaid_0000085
type: Species
initial concentration: NaN
name: tBid
has only substance units: false
is version of: REACT 385
constant: false
boundary condition: false
is version of: P55957
initial amount: 0.0
in compartment: metaid_0000074

metaid_0000057
type: Parameter
constant: true
value: 0.01
name: k_22

metaid_0000130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Apaf#

metaid_0000073
type: Parameter
constant: true
value: 0.07
name: v

metaid_0000173
type: Reaction
kinetic law: 743901
product: 743889
product: 743877
reactant: 743865
fast: false
reversible: false

743889
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

743877
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

metaid_0000127
type: Species
is version of: P99999
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: CytoC

743865
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000129

metaid_0000129
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: CytoC:Apaf

metaid_0000093
type: Species
is version of: Q07812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
in compartment: metaid_0000074
name: Bax

metaid_0000069
type: Parameter
constant: true
value: 0.001
name: k_27

metaid_0000080
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: casp6

metaid_0000053
type: Parameter
constant: true
value: 2.0E-6
name: k21

metaid_0000048
type: Parameter
constant: true
value: 0.001
name: k_19

metaid_0000100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: R#:pC8

metaid_0000156
type: Reaction
kinetic law: 743109
product: 743097
reactant: 743085
reactant: 743073
fast: false
reversible: true

743097
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

metaid_0000113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Bax:tBid

743085
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

743073
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

metaid_0000174
type: Reaction
kinetic law: 743949
product: 743937
reactant: 743925
reactant: 743913
fast: false
reversible: true

743937
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

metaid_0000105
type: Species
has part: P99999
initial concentration: NaN
has only substance units: false
boundary condition: false
initial amount: 0.0
is version of: GO:0043293
has part: P55211
in compartment: metaid_0000074
notes: apoptosome
name: Apop
is version of: REACT 5647
constant: false
has part: O14727

743925
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000131

743913
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

metaid_0000065
type: Parameter
constant: true
value: 1.0
name: kc25

metaid_0000044
type: Parameter
constant: true
value: 0.001
name: k_17

metaid_0000177
type: Parameter
constant: false
value: NaN
name: degraded C3 fraction

metaid_0000058
type: Parameter
constant: true
value: 5.0E-7
name: k23

metaid_0000166
type: Reaction
kinetic law: 743570
product: 743558
reactant: 743546
reactant: 743534
fast: false
reversible: true

743558
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

metaid_0000122
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: M#:Smac_m

743546
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

metaid_0000121
type: Species
initial concentration: NaN
initial amount: 100000.0
has only substance units: false
constant: false
name: Smac_m
in compartment: metaid_0000188
is version of: Q9NR28
boundary condition: false
is version of: REACT 5499

743534
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

metaid_0000120
type: Species
notes: opened inner mitochondrial membrane pore
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: M#

metaid_0000024
type: Parameter
constant: true
value: 1.0E-6
name: k9

metaid_0000170
type: Reaction
kinetic law: 743764
product: 743751
product: 743738
reactant: 743725
fast: false
reversible: false

743751
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

743738
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

metaid_0000126
type: Species
constant: false
has only substance units: false
is version of: REACT 3942
notes: cytochrom C released into the mitochondrial intermembrane space
boundary condition: false
name: CytoC released
in compartment: metaid_0000188
initial concentration: NaN
initial amount: 0.0
is version of: P99999

743725
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000125

metaid_0000125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: M#:CytoC_m

metaid_0000061
type: Parameter
constant: true
value: 5.0E-8
name: k24

metaid_0000040
type: Parameter
constant: true
value: 0.001
name: k_15

metaid_0000163
type: Reaction
kinetic law: 743435
product: 743423
reactant: 743411
reactant: 743399
fast: false
reversible: true

743423
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000117
type: Species
name: Bax4:Bcl2
has only substance units: false
initial concentration: NaN
initial amount: 0.0
constant: false
has part: Q07812
in compartment: metaid_0000188
boundary condition: false
has part: P10415

743411
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

743399
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000096

metaid_0000054
type: Parameter
constant: true
value: 0.001
name: k_21

metaid_0000146
type: Reaction
kinetic law: 742628
product: 742616
product: 742604
reactant: 742592
fast: false
reversible: false

742616
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

742604
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

742592
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000104

metaid_0000150
type: Reaction
kinetic law: 742821
product: 742809
product: 742796
reactant: 742784
fast: false
reversible: false

742809
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

742796
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000088

metaid_0000088
type: Species
initial concentration: NaN
constant: false
notes: ubiquitinylated caspase 3
boundary condition: false
has version: P62988
name: Ub C3
in compartment: metaid_0000074
has only substance units: false
initial amount: 0.0
has version: P42574

742784
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000108

metaid_0000178
type: Parameter
constant: false
value: NaN
name: cPARP fraction

metaid_0000059
type: Parameter
constant: true
value: 0.001
name: k_23

metaid_0000070
type: Parameter
constant: true
value: 7.0E-6
name: k28

metaid_0000020
type: Parameter
constant: true
value: 0.001
name: k_7

metaid_0000142
type: Reaction
kinetic law: 742436
product: 742424
product: 742412
reactant: 742400
is version of: http://identifiers.org/ec-code/3.4.22.61
fast: false
reversible: false

742424
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

742412
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

742400
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

metaid_0000103
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C8:pC3

metaid_0000050
type: Parameter
constant: true
value: 2.0E-6
name: k20

metaid_0000082
type: Species
is version of: P42574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10000.0
in compartment: metaid_0000074
name: proC3

metaid_0000076
type: Species
constant: false
notes: TRAIL receptor : for experiments without siRNA R = 200
is version of: REACT 2540
has only substance units: false
initial concentration: NaN
is version of: O14763
name: R
in compartment: metaid_0000074
initial amount: 200.0
boundary condition: false

metaid_0000055
type: Parameter
constant: true
value: 10.0
name: kc21

metaid_0000071
type: Parameter
constant: true
value: 0.001
name: k_28

metaid_0000137
type: Reaction
kinetic law: 742196
product: 742184
product: 742172
reactant: 742160
is part of: REACT 961
fast: false
reversible: false

742184
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

metaid_0000098
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: R#
initial amount: 0.0
notes: activated receptor
in compartment: metaid_0000074
is version of: O14763
boundary condition: false

742172
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

742160
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000100

metaid_0000171
type: Reaction
kinetic law: 743803
product: 743790
reactant: 743777
fast: false
reversible: true

743790
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

743777
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

metaid_0000067
type: Parameter
constant: true
value: 0.01
name: k_26

metaid_0000051
type: Parameter
constant: true
value: 0.001
name: k_20

metaid_0000046
type: Parameter
constant: true
value: 0.001
name: k_18

metaid_0000151
type: Reaction
kinetic law: 742869
product: 742857
reactant: 742845
reactant: 742833
fast: false
reversible: true

742857
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000109

metaid_0000109
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: PARP:C3

742845
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

742833
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

metaid_0000089
type: Species
is version of: P09874
in compartment: metaid_0000074
initial amount: 1000000.0
has only substance units: false
initial concentration: NaN
boundary condition: false
name: PARP
notes: EC substrate
constant: false

metaid_0000184
type: Parameter
constant: false
value: NaN
name: free C3 fraction

metaid_0000028
type: Parameter
constant: true
value: 0.001
name: k_10

metaid_0000081
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
in compartment: metaid_0000074
name: BAR

metaid_0000075
type: Species
initial concentration: NaN
is version of: P50591
notes: TRAIL : L = 3000 correspond to 50 ng/ml SuperKiller TRAIL for experiments under saturating conditions use L = 60000
constant: false
is version of: REACT 3803
has only substance units: false
boundary condition: false
initial amount: 3000.0
name: L
in compartment: metaid_0000074

metaid_0000168
type: Reaction
kinetic law: 743660
product: 743647
reactant: 743634
fast: false
reversible: true

743647
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

743634
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

metaid_0000123
type: Species
is version of: REACT 5375
initial concentration: NaN
name: Smac released
constant: false
has only substance units: false
initial amount: 0.0
in compartment: metaid_0000188
boundary condition: false
notes: Smac released into the mitochondrial intermembrane space
is version of: Q9NR28

metaid_0000138
type: Reaction
kinetic law: 742244
product: 742232
reactant: 742220
reactant: 742208
fast: false
reversible: true

742232
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000101

metaid_0000101
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C6:pC8

742220
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

metaid_0000078
type: Species
has only substance units: false
is version of: Q14790
name: proC8
constant: false
initial concentration: NaN
boundary condition: false
is version of: REACT 4998.1
initial amount: 20000.0
in compartment: metaid_0000074

742208
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

metaid_0000026
type: Parameter
constant: true
value: 1.0
name: kc9

metaid_0000172
type: Reaction
kinetic law: 743853
product: 743841
reactant: 743829
reactant: 743816
fast: false
reversible: true

743841
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000129

743829
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

metaid_0000128
type: Species
is version of: O14727
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
in compartment: metaid_0000074
name: Apaf

743816
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

metaid_0000063
type: Parameter
constant: true
value: 5.0E-9
name: k25

metaid_0000008
type: Parameter
constant: true
value: 1.0E-6
name: k3

metaid_0000042
type: Parameter
constant: true
value: 0.001
name: k_16

metaid_0000180
type: Parameter
constant: false
value: NaN
name: total Caspase 3

metaid_0000175
type: Parameter
constant: false
value: NaN
name: pC3 fraction

metaid_0000148
type: Reaction
kinetic law: 742724
product: 742712
product: 742700
reactant: 742688
fast: false
reversible: false

742712
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

742700
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

742688
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

metaid_0000152
type: Reaction
kinetic law: 742917
product: 742905
product: 742893
reactant: 742881
fast: false
reversible: false

742905
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

742893
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000090

metaid_0000090
type: Species
is version of: P09874
initial amount: 0.0
in compartment: metaid_0000074
initial concentration: NaN
name: cPARP
has only substance units: false
boundary condition: false
notes: cleaved PARP
constant: false

742881
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000109

metaid_0000022
type: Parameter
constant: true
value: 0.001
name: k_8

metaid_0000004
type: Parameter
constant: true
value: 0.001
name: k_1

metaid_0000036
type: Parameter
constant: true
value: 0.01
name: k_13

metaid_0000144
type: Reaction
kinetic law: 742532
product: 742520
product: 742508
reactant: 742496
is version of: http://identifiers.org/ec-code/3.4.22.61
fast: false
reversible: false

742520
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

742508
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

742496
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000106

metaid_0000176
type: Parameter
constant: false
value: NaN
name: C3 fraction

metaid_0000003
type: Parameter
constant: true
value: 4.0E-7
name: k1

metaid_0000016
type: Parameter
constant: true
value: 1.0E-6
name: k6

metaid_0000162
type: Reaction
kinetic law: 743387
product: 743375
reactant: 743363
reactant: 743351
fast: false
reversible: true

743375
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

743363
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000190

743351
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000096

metaid_0000139
type: Reaction
kinetic law: 742292
product: 742280
product: 742268
reactant: 742256
fast: false
reversible: false

742280
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

742268
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

742256
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000101

metaid_0000099
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: flip:R#

metaid_0000032
type: Parameter
constant: true
value: 1.0E-7
name: k12

metaid_0000119
type: Species
has part: Q07812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: Bax4:M

metaid_0000037
type: Parameter
constant: true
value: 1.0E-6
name: k14

metaid_0000012
type: Parameter
constant: true
value: 0.001
name: k_4

metaid_0000017
type: Parameter
constant: true
value: 0.001
name: k_6

metaid_0000049
type: Parameter
constant: true
value: 1.0
name: kc19

metaid_0000033
type: Parameter
constant: true
value: 0.001
name: k_12

metaid_0000118
type: Species
notes: binding sites for activated Bax on the inner mitochondrial membrane
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 500000.0
in compartment: metaid_0000188
name: M

metaid_0000013
type: Parameter
constant: true
value: 1.0E-7
name: k5

metaid_0000045
type: Parameter
constant: true
value: 1.0E-6
name: k18

metaid_0000006
type: Parameter
constant: true
value: 1.0E-6
name: k2

metaid_0000038
type: Parameter
constant: true
value: 0.001
name: k_14

metaid_0000025
type: Parameter
constant: true
value: 0.01
name: k_9

metaid_0000041
type: Parameter
constant: true
value: 1.0E-6
name: k16

metaid_0000018
type: Parameter
constant: true
value: 1.0
name: kc6

metaid_0000164
type: Reaction
kinetic law: 743484
product: 743472
reactant: 743460
reactant: 743448
fast: false
reversible: true

743472
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

743460
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

743448
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000034
type: Parameter
constant: true
value: 1.0
name: kc12

metaid_0000021
type: Parameter
constant: true
value: 2.0E-6
name: k8

metaid_0000039
type: Parameter
constant: true
value: 1.0E-6
name: k15

metaid_0000014
type: Parameter
constant: true
value: 0.001
name: k_5

metaid_0000160
type: Reaction
kinetic law: 743291
product: 743279
reactant: 743267
reactant: 743255
fast: false
reversible: true

743279
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000190

743267
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000189

743255
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000189

metaid_0000068
type: Parameter
constant: true
value: 2.0E-6
name: k27

metaid_0000019
type: Parameter
constant: true
value: 3.0E-8
name: k7

metaid_0000030
type: Parameter
constant: true
value: 1.0E-6
name: k11

metaid_0000035
type: Parameter
constant: true
value: 0.01
name: k13

metaid_0000140
type: Reaction
kinetic law: 742340
product: 742328
reactant: 742316
reactant: 742304
fast: false
reversible: true

742328
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000102

metaid_0000102
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: BAR:C8

742316
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000081

742304
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

metaid_0000133
type: Reaction
kinetic law: 742016
product: 742004
reactant: 741992
reactant: 741980
is version of: GO:0045569
fast: false
reversible: true

742004
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000097

metaid_0000097
type: Species
notes: TRAIL-receptor complex
has only substance units: false
constant: false
name: L:R
is version of: REACT 5556
initial amount: 0.0
has version: P50591
in compartment: metaid_0000074
boundary condition: false
initial concentration: NaN
has version: O14763

741992
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

741980
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000010
type: Parameter
constant: true
value: 1.0
name: kc3

metaid_0000169
type: Reaction
kinetic law: 743712
product: 743699
reactant: 743686
reactant: 743673
fast: false
reversible: true

743699
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000125

743686
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

743673
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

metaid_0000064
type: Parameter
constant: true
value: 0.001
name: k_25

metaid_0000015
type: Parameter
constant: true
value: 1.0
name: kc5

metaid_0000047
type: Parameter
constant: true
value: 1.0E-6
name: k19

metaid_0000031
type: Parameter
constant: true
value: 0.001
name: k_11

metaid_0000029
type: Parameter
constant: true
value: 1.0
name: kc10

metaid_0000165
type: Reaction
kinetic law: 743521
product: 743509
reactant: 743497
fast: false
reversible: false

743509
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

743497
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000134
type: Reaction
kinetic law: 742052
product: 742040
reactant: 742028
fast: false
reversible: false

742040
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

742028
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000097

metaid_0000027
type: Parameter
constant: true
value: 1.0E-7
name: k10

metaid_0000060
type: Parameter
constant: true
value: 1.0
name: kc23

metaid_0000011
type: Parameter
constant: true
value: 1.0E-6
name: k4

metaid_0000009
type: Parameter
constant: true
value: 0.001
name: k_3

metaid_0000043
type: Parameter
constant: true
value: 1.0E-6
name: k17

metaid_0000145
type: Reaction
kinetic law: 742580
product: 742568
reactant: 742556
reactant: 742544
fast: false
reversible: true

742568
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000104

742556
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

742544
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

metaid_0000023
type: Parameter
constant: true
value: 0.1
name: kc8

W3 CDTF: Wed Jul 01 18:12:55 BST 2009

metaid_0000005
type: Parameter
constant: true
value: 1.0E-5
name: kc1

metaid_0000157
type: Reaction
kinetic law: 743157
product: 743145
product: 743133
reactant: 743121
fast: false
reversible: false

743145
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

743133
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

743121
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

metaid_0000141
type: Reaction
kinetic law: 742388
product: 742376
reactant: 742364
reactant: 742352
fast: false
reversible: true

742376
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

742364
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

742352
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

ORG:
  orgname: Institut Curie
n:
  given: Simon
  family: Fourquet

metaid_0000135
type: Reaction
kinetic law: 742100
product: 742088
reactant: 742076
reactant: 742064
fast: false
reversible: true

742088
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000099

742076
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

metaid_0000077
type: Species
in compartment: metaid_0000074
has only substance units: false
is described by: http://identifiers.org/omim/603599
is version of: REACT 2438
initial amount: 100.0
initial concentration: NaN
boundary condition: false
is version of: O15519
constant: false
name: flip

742064
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

metaid_0000153
type: Reaction
kinetic law: 742965
product: 742953
reactant: 742941
reactant: 742929
fast: false
reversible: true

742953
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000110

metaid_0000110
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Apop:XIAP

742941
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

742929
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

metaid_0000066
type: Parameter
constant: true
value: 0.01
name: k26

metaid_0000158
type: Reaction
kinetic law: 743194
product: 743181
reactant: 743169
fast: false
reversible: true

743181
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000189

743169
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

W3 CDTF: Thu Jul 05 15:42:40 BST 2012

metaid_0000167
type: Reaction
kinetic law: 743621
product: 743608
product: 743596
reactant: 743583
fast: false
reversible: false

743608
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

743596
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

743583
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

metaid_0000136
type: Reaction
kinetic law: 742148
product: 742136
reactant: 742124
reactant: 742112
is part of: REACT 961
fast: false
reversible: true

742136
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000100

742124
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

742112
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler