BIOMD0000000208
type: SBMLModel
occurs in: http://identifiers.org/taxonomy/40674
length unit: length
parameter: metaid_0000011
parameter: metaid_0000010
volume units: metaid_0000059
parameter: metaid_0000006
time units: metaid_0000062
is version of: hsa04110
substance units: metaid_0000044
species: metaid_0000023
reaction: metaid_0000035
area units: metaid_0000005
reaction: metaid_0000040
parameter: metaid_0000017
parameter: metaid_0000016
notes: The model reproduces Fig 3 of the paper corresponding to the transition to S phase. Units have not been defined for this model because the paper mentions the use of arbitrary units for the various species and parameters. Model reproduced using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: metaid_0000026
reaction: metaid_0000031
is version of: GO:0000278
reaction: metaid_0000030
parameter: metaid_0000012
rule: metaid_0000044
parameter: metaid_0000008
parameter: metaid_0000007
species: metaid_0000025
is: MODEL1475866846
reaction: metaid_0000037
reaction: metaid_0000042
reaction: metaid_0000036
reaction: metaid_0000041
species: metaid_0000028
reaction: metaid_0000033
reaction: metaid_0000032
parameter: metaid_0000004
parameter: metaid_0000003
parameter: metaid_0000013
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
curated: true
parameter: metaid_0000009
compartment: metaid_0000021
created:
  W3 CDTF: Sat Sep 13 06:21:44 BST 2008
name: Deineko2003_CellCycle
reaction: metaid_0000039
reaction: metaid_0000029
reaction: metaid_0000038
is described by: http://identifiers.org/pubmed/14582399
parameter: metaid_0000020
reaction: metaid_0000043
species: metaid_0000024
parameter: metaid_0000019
parameter: metaid_0000018
reaction: metaid_0000034
parameter: metaid_0000005
parameter: metaid_0000015
parameter: metaid_0000014
species: metaid_0000027
modified:
  W3 CDTF: Thu Jul 05 15:41:04 BST 2012

metaid_0000011
type: Parameter
constant: true
value: 0.1

metaid_0000010
type: Parameter
constant: true
value: 0.01

metaid_0000006
type: Parameter
constant: true
value: 10.0

metaid_0000023
type: Species
is version of: Q01094
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.014
initial amount: NaN
in compartment: metaid_0000021
name: E2F

metaid_0000021
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000035
type: Reaction
kinetic law: 655658
modifier: 655646
product: 655634
is version of: GO:0045727
is version of: GO:0003700
fast: false
reversible: false

655634
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000026
type: Species
initial amount: NaN
boundary condition: false
has part: P24864
constant: false
has only substance units: false
in compartment: metaid_0000021
has part: P24941
name: inactive cycE_cdk2
initial concentration: 0.0

metaid_0000040
type: Reaction
kinetic law: 655815
reactant: 655803
is version of: GO:0019941
fast: false
reversible: false

655803
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000027
type: Species
constant: false
has part: P24941
name: active cycE_cdk2
has only substance units: false
boundary condition: false
has part: P24864
initial concentration: 1.0E-4
initial amount: NaN
in compartment: metaid_0000021

metaid_0000017
type: Parameter
constant: true
value: 0.01

metaid_0000016
type: Parameter
constant: true
value: 0.01

metaid_0000031
type: Reaction
kinetic law: 655525
modifier: 655513
product: 655501
is version of: GO:0045727
is version of: GO:0003700
fast: false
reversible: false

655501
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000024
type: Species
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.006
initial amount: NaN
in compartment: metaid_0000021
name: pRB

metaid_0000030
type: Reaction
kinetic law: 655489
reactant: 655477
is version of: GO:0019941
fast: false
reversible: false

655477
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000012
type: Parameter
constant: true
value: 0.09

metaid_0000008
type: Parameter
constant: true
value: 1.0

metaid_0000007
type: Parameter
constant: true
value: 0.1

metaid_0000025
type: Species
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000021
name: Phosphorylated pRB

metaid_0000037
type: Reaction
kinetic law: 655731
product: 655719
reactant: 655707
is version of: GO:0000082
fast: false
reversible: false

655719
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

655707
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000042
type: Reaction
kinetic law: 655875
product: 655863
is version of: GO:0006412
fast: false
reversible: false

655863
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000028
type: Species
is version of: P05412
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000021
name: AP-1

metaid_0000036
type: Reaction
kinetic law: 655695
modifier: 655683
product: 655671
is version of: GO:0045727
is version of: GO:0003700
fast: false
reversible: false

655671
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000041
type: Reaction
kinetic law: 655851
modifier: 655839
product: 655827
is version of: GO:0003700
is version of: GO:0045727
fast: false
reversible: false

655827
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000033
type: Reaction
kinetic law: 655597
reactant: 655585
is version of: GO:0019941
fast: false
reversible: false

655585
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000032
type: Reaction
kinetic law: 655573
modifier: 655561
product: 655549
reactant: 655537
is version of: GO:0004693
fast: false
reversible: false

655549
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

655537
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000004
type: Parameter
constant: true
value: 1.0

metaid_0000003
type: Parameter
constant: true
value: 2.0

metaid_0000013
type: Parameter
constant: true
value: 0.1

metaid_0000009
type: Parameter
constant: true
value: 0.4

metaid_0000039
type: Reaction
kinetic law: 655791
reactant: 655779
fast: false
reversible: false

655779
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000029
type: Reaction
kinetic law: 655465
modifier: 655453
product: 655441
is version of: GO:0006412
fast: false
reversible: false

655441
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000038
type: Reaction
kinetic law: 655767
product: 655755
reactant: 655743
fast: false
reversible: false

655755
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

655743
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000020
type: Parameter
constant: true
value: 0.1

metaid_0000043
type: Reaction
kinetic law: 655899
reactant: 655887
is version of: GO:0019941
fast: false
reversible: false

655887
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000019
type: Parameter
constant: false
value: 0.044

metaid_0000018
type: Parameter
constant: true
value: 0.0

metaid_0000034
type: Reaction
kinetic law: 655621
reactant: 655609
is version of: GO:0019941
fast: false
reversible: false

655609
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000005
type: Parameter
constant: true
value: 1.0

metaid_0000015
type: Parameter
constant: true
value: 2.0

metaid_0000014
type: Parameter
constant: true
value: 1.0