BIOMD0000000207
type: SBMLModel
parameter: metaid_0000030
parameter: metaid_0000025
parameter: metaid_0000010
parameter: metaid_0000013
parameter: metaid_0000004
parameter: metaid_0000008
parameter: metaid_0000033
parameter: metaid_0000028
species: metaid_0000042
parameter: metaid_0000016
units def: metaid_0000065
reaction: metaid_0000049
name: Romond1999_CellCycle
reaction: metaid_0000054
units def: metaid_0000064
length unit: length
rule: metaid_0000070
parameter: metaid_0000021
curated: true
parameter: metaid_0000024
rule: metaid_0000043
compartment: metaid_0000035
parameter: metaid_0000012
substance units: metaid_0000044
parameter: metaid_0000003
is: MODEL1111382868
parameter: metaid_0000007
is version of: hsa04110
parameter: metaid_0000032
parameter: metaid_0000027
modified:
  W3 CDTF: Thu Jul 05 17:48:46 BST 2012
parameter: metaid_0000015
parameter: metaid_0000019
notes: The model reproduces Fig 3 of the paper. Model successfully reproduced using MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
is described by: http://identifiers.org/pubmed/10415827
reaction: metaid_0000048
species: metaid_0000038
reaction: metaid_0000056
rule: metaid_0000071
units def: metaid_0000063
parameter: metaid_0000020
rule: metaid_0000046
units def: metaid_0000062
parameter: metaid_0000023
rule: metaid_0000044
species: metaid_0000037
parameter: metaid_0000006
rule: metaid_0000073
parameter: metaid_0000031
parameter: metaid_0000026
parameter: metaid_0000011
volume units: metaid_0000059
parameter: metaid_0000034
parameter: metaid_0000014
parameter: metaid_0000018
parameter: metaid_0000005
parameter: metaid_0000009
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
reaction: metaid_0000047
species: metaid_0000041
parameter: metaid_0000029
units def: metaid_0000066
occurs in: http://identifiers.org/taxonomy/2759
parameter: metaid_0000017
time units: metaid_0000062
created:
  W3 CDTF: Wed Sep 10 14:58:58 BST 2008
area units: metaid_0000005
species: metaid_0000039
is version of: GO:0000278
reaction: metaid_0000055
rule: metaid_0000045
species: metaid_0000040
parameter: metaid_0000022
rule: metaid_0000075

metaid_0000030
type: Parameter
constant: true
units: metaid_0000065
value: 0.15

metaid_0000065
type: SBMLUnitsDef
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name: min_1

312686
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scale: 0
multipler: 60.0
kind: SECOND

metaid_0000025
type: Parameter
constant: true
units: dimensionless
value: 0.03

metaid_0000010
type: Parameter
constant: true
units: metaid_0000065
value: 0.3

metaid_0000013
type: Parameter
constant: true
units: metaid_0000066
value: 0.05

metaid_0000066
type: SBMLUnitsDef
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unit: 312710
unit: 312698
name: uM_min_1

312722
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kind: SECOND

312710
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scale: 0
multipler: 1.0
kind: LITRE

312698
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scale: -6
multipler: 1.0
kind: MOLE

metaid_0000004
type: Parameter
constant: true
units: metaid_0000063
value: 0.5

metaid_0000063
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unit: 312650
name: uM

312662
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scale: 0
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kind: LITRE

312650
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kind: MOLE

metaid_0000008
type: Parameter
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units: metaid_0000065
value: 0.0

metaid_0000033
type: Parameter
constant: true
units: metaid_0000065
value: 0.05

metaid_0000028
type: Parameter
constant: true
units: metaid_0000065
value: 0.001

metaid_0000042
type: Species
is version of: Q9UBT2
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000035
name: Ubiquitin ligase 2
has only substance units: true
initial amount: 0.0
substance units: dimensionless
constant: false

metaid_0000035
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000016
type: Parameter
constant: true
units: metaid_0000063
value: 0.02

metaid_0000049
type: Reaction
kinetic law: 312818
reactant: 312806
is version of: GO:0008054
fast: false
reversible: false
name: cyclinB degradation

312806
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000037
type: Species
name: cyclinB
constant: false
substance units: metaid_0000064
is version of: Q8WWL7
initial concentration: 2.0
has only substance units: false
boundary condition: false
initial amount: NaN
in compartment: metaid_0000035

metaid_0000064
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name: micromole

312674
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scale: -6
multipler: 1.0
kind: MOLE

metaid_0000054
type: Reaction
kinetic law: 312854
modifier: 312842
product: 312830
fast: false
reversible: false
name: cyclinE synthesis

metaid_0000038
type: Species
boundary condition: false
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is version of: P06493
substance units: dimensionless
has only substance units: true
initial amount: 1.0
name: cdk1
constant: false
initial concentration: NaN

312830
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000040
type: Species
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boundary condition: false
substance units: metaid_0000064
constant: false
is version of: P24864
has only substance units: false
initial concentration: 0.0
name: cyclinE

metaid_0000021
type: Parameter
constant: true
units: dimensionless
value: 0.01

metaid_0000024
type: Parameter
constant: true
units: metaid_0000066
value: 0.05

metaid_0000012
type: Parameter
constant: true
units: metaid_0000065
value: 0.1

metaid_0000003
type: Parameter
constant: false
units: metaid_0000065
value: 0.0

metaid_0000007
type: Parameter
constant: true
units: metaid_0000065
value: 0.1

metaid_0000032
type: Parameter
constant: true
units: dimensionless
value: 0.01

metaid_0000027
type: Parameter
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units: metaid_0000063
value: 0.02

metaid_0000015
type: Parameter
constant: true
units: metaid_0000066
value: 0.025

metaid_0000019
type: Parameter
constant: true
units: metaid_0000065
value: 0.15

metaid_0000048
type: Reaction
kinetic law: 312794
modifier: 312782
reactant: 312770
is version of: GO:0008054
fast: false
reversible: false
name: Ubiquitin ligase mediated cyclinB degradation

metaid_0000039
type: Species
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substance units: dimensionless
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constant: false
name: ubiquitin ligase
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is version of: Q9UBT2

312770
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000056
type: Reaction
kinetic law: 312914
reactant: 312902
is version of: GO:0008054
fast: false
reversible: false
name: cyclinE degradation

312902
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000020
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constant: true
units: dimensionless
value: 0.01

metaid_0000062
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312638
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metaid_0000023
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metaid_0000006
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units: metaid_0000065
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metaid_0000031
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metaid_0000026
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metaid_0000011
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metaid_0000034
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metaid_0000014
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metaid_0000018
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metaid_0000005
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metaid_0000009
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metaid_0000047
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modifier: 312746
product: 312734
is version of: GO:0004693
fast: false
reversible: false
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metaid_0000041
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initial concentration: NaN
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is version of: P24941
has only substance units: true
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boundary condition: false
initial amount: 0.0

312734
type: SpeciesReference
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species: metaid_0000037

metaid_0000029
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value: 0.01

metaid_0000017
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units: metaid_0000065
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metaid_0000055
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modifier: 312878
reactant: 312866
is version of: GO:0008054
fast: false
reversible: false
name: Ubiquitin ligase mediated cyclinE degradation

312866
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000022
type: Parameter
constant: true
units: metaid_0000065
value: 0.05