BIOMD0000000197
type: SBMLModel
rule: metaid_0000038
volume units: metaid_0000040
parameter: metaid_0000034
parameter: metaid_0000030
parameter: metaid_0000029
parameter: metaid_0000033
reaction: 294797
modified:
  W3 CDTF: Thu Jul 05 15:47:47 BST 2012
is described by: http://identifiers.org/pubmed/17548463
species: 294657
compartment: 394597
species: 294888
units def: metaid_0000040
species: 294617
occurs in: http://identifiers.org/taxonomy/40674
notes: SBML model exported from PottersWheel on 2007-09-19 15:35:47. The values for parameters and the inital concentrations of this model where directly provided by the main author: Parameter values parameter value unit p1 0.0025 1/min p2 0.0784 1/min p3 0.0013 1/min p4 0.0827 1/min p5 0.0091 1/min p6 0.000064 1/(nmole*min) p7 0.0397 1/min p8 1000 nmole p9 0.0098 1/(nmole*min) p10 1.6 1/min p11 1000 nmole p12 0.0003 ml/min The basal chamber volume was taken as 1 ml, the apical as 1.5. As starting values x1 was set to 88 nmole, all other species to 0. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: 294757
species: 294697
parameter: metaid_0000024
species: 294637
parameter: metaid_0000032
parameter: metaid_0000031
substance units: metaid_0000039
species: 294889
units def: metaid_0000042
creator:
  ORG:
    orgname: Department for brain research, Anatomical Institute I, Hansastr. 9a, D-79104 Freiburg, Germany
  n:
    given: Kilian
    family: Bartholomé
species: 294677
reaction: 294777
compartment: 294597
parameter: metaid_0000028
created:
  W3 CDTF: Thu Sep 25 17:51:05 BST 2008
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
reaction: 294817
reaction: 294837
units def: metaid_0000044
is version of: GO:0006810
rule: metaid_0000037
reaction: 294717
parameter: metaid_0000023
reaction: 294737
curated: true
parameter: metaid_0010024
units def: metaid_0000039
length unit: length
is: MODEL0212154960
reaction: 294897
units def: metaid_0000041
name: Bartholome2007_MDCKII
parameter: metaid_0000027
units def: metaid_0000043
reaction: 294857
reaction: 294877
area units: metaid_0000005
time units: metaid_0000041
compartment: 494597
parameter: metaid_0000026

metaid_0000040
type: SBMLUnitsDef
unit: 059514
name: ml

059514
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE

metaid_0000034
type: Parameter
constant: true
units: metaid_0000043
value: 3.0E-4

metaid_0000043
type: SBMLUnitsDef
unit: 059562
unit: 059550
name: ml_per_min

059562
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

059550
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE

metaid_0000030
type: Parameter
constant: true
units: metaid_0000039
value: 1000.0

metaid_0000039
type: SBMLUnitsDef
unit: 059502
name: nmole

059502
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000029
type: Parameter
constant: true
units: metaid_0000042
value: 0.0397

metaid_0000042
type: SBMLUnitsDef
unit: 059538
name: permin

059538
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000033
type: Parameter
constant: true
units: metaid_0000039
value: 1000.0

294797
type: Reaction
kinetic law: 059767
product: 059755
reactant: 059743
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: endogenous apical export

059755
type: SpeciesReference
stoichiometry: 1.0
species: 294697

294697
type: Species
has only substance units: true
in compartment: 494597
is: C11363
constant: false
initial amount: 0.0
initial concentration: NaN
name: apical BSP
boundary condition: false
is: SBO:0000247

494597
type: Compartment
is: GO:0005615
is: SBO:0000290
constant: true
size: 1.5
spatial dimensions: 3.0
name: apical extracellular space

059743
type: SpeciesReference
stoichiometry: 1.0
species: 294657

294657
type: Species
initial amount: 0.0
initial concentration: NaN
name: free intracellular BSP
is: SBO:0000247
constant: false
is: C11363
in compartment: 394597
boundary condition: false
has only substance units: true

394597
type: Compartment
is: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: intracellular

294888
type: Species
in compartment: 494597
is: SBO:0000247
is: C11363
boundary condition: true
initial amount: NaN
has only substance units: true
constant: false
initial concentration: NaN
name: total BSP

294617
type: Species
name: free basolateral BSP
initial amount: 88.0
initial concentration: NaN
is: C11363
boundary condition: false
constant: false
is: SBO:0000247
in compartment: 294597
has only substance units: true

294597
type: Compartment
is: GO:0005615
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: basolateral extrocellular space

294757
type: Reaction
kinetic law: 059695
product: 059683
reactant: 059671
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: endogenous basolateral import

059683
type: SpeciesReference
stoichiometry: 1.0
species: 294657

059671
type: SpeciesReference
stoichiometry: 1.0
species: 294617

metaid_0000024
type: Parameter
constant: true
units: metaid_0000042
value: 0.0784

294637
type: Species
name: basolateral bound BSP
initial amount: 0.0
is: C11363
has only substance units: true
boundary condition: false
in compartment: 294597
initial concentration: NaN
is: SBO:0000247
constant: false

metaid_0000032
type: Parameter
constant: true
units: metaid_0000042
value: 1.6

metaid_0000031
type: Parameter
constant: true
units: metaid_0000044
value: 0.0098

metaid_0000044
type: SBMLUnitsDef
unit: 059587
unit: 059574
name: per_nmole_per_ml

059587
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

059574
type: SBMLUnit
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE

294889
type: Species
has only substance units: true
is: SBO:0000247
is: C11363
initial concentration: NaN
in compartment: 394597
name: intracellular BSP
boundary condition: true
initial amount: NaN
constant: false

294677
type: Species
is: SBO:0000247
in compartment: 394597
initial concentration: NaN
has only substance units: true
name: bound intracellular BSP
initial amount: 0.0
boundary condition: false
constant: false
is: C11363

294777
type: Reaction
kinetic law: 059731
product: 059719
reactant: 059707
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: endogenous basolateral export

059719
type: SpeciesReference
stoichiometry: 1.0
species: 294617

059707
type: SpeciesReference
stoichiometry: 1.0
species: 294657

metaid_0000028
type: Parameter
constant: true
units: metaid_0000044
value: 6.4E-5

294817
type: Reaction
kinetic law: 059803
product: 059791
reactant: 059779
is version of: GO:0005488
is: SBO:0000177
fast: false
reversible: false
name: basolateral BSP binding

059791
type: SpeciesReference
stoichiometry: 1.0
species: 294637

059779
type: SpeciesReference
stoichiometry: 1.0
species: 294617

294837
type: Reaction
kinetic law: 059839
product: 059827
reactant: 059815
is: SBO:0000180
fast: false
reversible: false
name: basolateral BSP dissoc

059827
type: SpeciesReference
stoichiometry: 1.0
species: 294617

059815
type: SpeciesReference
stoichiometry: 1.0
species: 294637

294717
type: Reaction
kinetic law: 059622
product: 059611
reactant: 059598
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: OATP1B3 mediated import

059611
type: SpeciesReference
stoichiometry: 1.0
species: 294657

059598
type: SpeciesReference
stoichiometry: 1.0
species: 294617

metaid_0000023
type: Parameter
constant: true
units: metaid_0000042
value: 0.0025

294737
type: Reaction
fast: false
name: ABCC2 mediated export
reversible: false
is: SBO:0000185
reactant: 059634
product: 059647
is version of: hsa02010
kinetic law: 059659
is version of: GO:0015415

059634
type: SpeciesReference
stoichiometry: 1.0
species: 294657

059647
type: SpeciesReference
stoichiometry: 1.0
species: 294697

metaid_0010024
type: Parameter
constant: true
units: metaid_0000042
value: 0.0013

294897
type: Reaction
kinetic law: 059948
product: 059936
reactant: 059924
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: true
name: paracellular transport

059936
type: SpeciesReference
stoichiometry: 1.0
species: 294697

059924
type: SpeciesReference
stoichiometry: 1.0
species: 294617

metaid_0000041
type: SBMLUnitsDef
unit: 059526
name: min

059526
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000027
type: Parameter
constant: true
units: metaid_0000042
value: 0.0091

294857
type: Reaction
kinetic law: 059875
product: 059863
reactant: 059851
is version of: GO:0005488
is: SBO:0000177
fast: false
reversible: false
name: cellular BSP binding

059863
type: SpeciesReference
stoichiometry: 1.0
species: 294677

059851
type: SpeciesReference
stoichiometry: 1.0
species: 294657

294877
type: Reaction
kinetic law: 059912
product: 059899
reactant: 059887
is: SBO:0000180
fast: false
reversible: false
name: cellular BSP dissoc

059899
type: SpeciesReference
stoichiometry: 1.0
species: 294657

059887
type: SpeciesReference
stoichiometry: 1.0
species: 294677

metaid_0000026
type: Parameter
constant: true
units: metaid_0000042
value: 0.0827