BIOMD0000000196
type: SBMLModel
parameter: metaid_0000012
parameter: metaid_0000032
parameter: metaid_0000025
parameter: metaid_0000019
parameter: metaid_0000039
length unit: length
parameter: metaid_0000020
parameter: metaid_0000013
parameter: metaid_0000033
reaction: metaid_0000068
rule: metaid_0000072
reaction: metaid_0000067
parameter: metaid_0000018
function def: metaid_0000003
species: metaid_0000043
species: metaid_0000046
parameter: metaid_0000006
reaction: metaid_0000066
parameter: metaid_0000016
is: MODEL1502077979
parameter: metaid_0000036
reaction: metaid_0000062
name: Srividhya2006_CellCycle
reaction: metaid_0000065
parameter: metaid_0000024
name: Mass_Action_2
reaction: metaid_0000061
parameter: metaid_0000037
species: metaid_0000049
is described by: http://identifiers.org/pubmed/16473373
area units: metaid_0000005
parameter: metaid_0000023
parameter: metaid_0000011
notes: In this model the values of "free CDK" (Id: x2), "cdc25_P" (x4) "Wee1_P" (Id: y5) and "APC" (Id: y6) are assigned using the parameters describing the total concentrations totcdk (Id: c)), totcdc5, totwee1 and totAPC. So if you want to change the levels of these proteins, you need to change the values ofthese parameters. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
parameter: metaid_0000031
name: Mass_Action_0
volume units: metaid_0000004
species: metaid_0000051
rule: metaid_0000073
reaction: metaid_0000059
parameter: metaid_0000009
parameter: metaid_0000029
species: metaid_0000042
species: metaid_0000044
parameter: metaid_0000010
curated: true
reaction: metaid_0000064
parameter: metaid_0000017
parameter: metaid_0000040
parameter: metaid_0000027
reaction: metaid_0000060
reaction: metaid_0000058
parameter: metaid_0000015
time units: metaid_0000081
parameter: metaid_0000035
function def: metaid_0000005
occurs in: http://identifiers.org/taxonomy/2759
species: metaid_0000047
is version of: GO:0007049
species: metaid_0000052
parameter: metaid_0000014
parameter: metaid_0000008
parameter: metaid_0000034
parameter: metaid_0000028
rule: metaid_0000074
parameter: metaid_0000007
parameter: metaid_0000022
reaction: metaid_0000063
rule: metaid_0000071
parameter: metaid_0000021
is version of: REACT 152
reaction: metaid_0000069
substance units: metaid_0000080
function def: metaid_0000004
event: metaid_0000070
species: metaid_0000045
reaction: metaid_0000057
species: metaid_0000048
parameter: metaid_0000038

metaid_0000012
type: Parameter
constant: true
value: 0.7
name: vM1

metaid_0000032
type: Parameter
constant: true
value: 0.01
name: j4

metaid_0000025
type: Parameter
constant: true
value: 1.0
name: vM3

metaid_0000019
type: Parameter
constant: true
value: 0.41
name: vM2

metaid_0000039
type: Parameter
constant: true
value: 1.0
name: totAPC

metaid_0000020
type: Parameter
constant: true
value: 1.0
name: a2

metaid_0000013
type: Parameter
constant: true
value: 1.2
name: a1

metaid_0000033
type: Parameter
constant: true
value: 1.0
name: v'M4

metaid_0000068
type: Reaction
kinetic law: 361535
product: 361523
reactant: 361511
is version of: GO:0016311
fast: false
reversible: false
name: APC dephosphorylation

361523
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

metaid_0000051
type: Species
is version of: GO:0005680
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000041
name: APC

metaid_0000041
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

361511
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

metaid_0000047
type: Species
initial concentration: NaN
name: APC_P
has version: C00562
has only substance units: false
boundary condition: false
initial amount: 0.1
constant: false
in compartment: metaid_0000041
is version of: GO:0005680

metaid_0000067
type: Reaction
kinetic law: 361499
name: APC phosphorylation
product: 361463
reactant: 361451
is version of: GO:0016310
modifier: 361487
reversible: false
modifier: 361475
fast: false

361463
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

361451
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

metaid_0000044
type: Species
has version: P14635
initial amount: 0.1
name: MPF
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000041
constant: false
has only substance units: false
has version: P06493
is version of: GO:0031387

metaid_0000048
type: Species
is version of: GO:0005623
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.473
in compartment: metaid_0000041
name: cell_mass

metaid_0000018
type: Parameter
constant: true
value: 0.01
name: j'1

metaid_0000043
type: Species
initial amount: NaN
name: free CDK
in compartment: metaid_0000041
has only substance units: false
is version of: GO:0004672
is homolog to: P06493
constant: false
initial concentration: NaN
boundary condition: true

metaid_0000046
type: Species
is homolog to: P30291
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.1
in compartment: metaid_0000041
name: Wee1

metaid_0000006
type: Parameter
constant: true
value: 0.215
name: vf

metaid_0000066
type: Reaction
is version of: REACT 1944.2
modifier: 361415
product: 361403
reversible: false
reactant: 361390
is version of: GO:0016310
fast: false
kinetic law: 361439
modifier: 361427
name: wee1 phosphorylation

361403
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

metaid_0000050
type: Species
name: Wee1_P
is homolog to: P30291
constant: false
boundary condition: true
is version of: C00562
initial amount: NaN
has only substance units: false
initial concentration: NaN
in compartment: metaid_0000041

361390
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000016
type: Parameter
constant: true
value: 5.0
name: B1

metaid_0000036
type: Parameter
constant: true
value: 10.0
name: a

metaid_0000062
type: Reaction
kinetic law: 361246
modifier: 361234
product: 361222
reactant: 361210
is version of: REACT 6178.2
fast: false
reversible: false
name: MPF -> Pre-MPF transition

361222
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

metaid_0000052
type: Species
constant: false
name: Pre_MPF
initial concentration: NaN
has version: P06493
in compartment: metaid_0000041
is version of: GO:0031387
is version of: GO:0000307
has version: IPR015454
initial amount: 0.2
has only substance units: false
boundary condition: false

361210
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000065
type: Reaction
kinetic law: 361378
product: 361366
reactant: 361354
is version of: GO:0016311
fast: false
reversible: false
name: wee1 dephosphorylation

361366
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

361354
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

metaid_0000024
type: Parameter
constant: true
value: 0.01
name: j'2

metaid_0000061
type: Reaction
kinetic law: 361198
modifier: 361186
product: 361174
reactant: 361162
is version of: REACT 6255.1
fast: false
reversible: false
name: Pre-MPF -> MPF transition

metaid_0000045
type: Species
boundary condition: true
initial amount: NaN
is version of: C00562
in compartment: metaid_0000041
constant: false
has only substance units: false
initial concentration: NaN
is homolog to: P04821
is homolog to: P30304
name: cdc25_P

361174
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

361162
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

metaid_0000037
type: Parameter
constant: true
value: 1.0
name: totcdc25

metaid_0000049
type: Species
initial amount: 0.9
initial concentration: NaN
boundary condition: false
has only substance units: false
constant: false
is homolog to: P30304
in compartment: metaid_0000041
is homolog to: P04821
name: cdc25

metaid_0000023
type: Parameter
constant: true
value: 0.01
name: j'3

metaid_0000011
type: Parameter
constant: true
value: 3.3
name: B2

metaid_0000031
type: Parameter
constant: true
value: 5.0
name: tau

metaid_0000059
type: Reaction
kinetic law: 361101
modifier: 361089
reactant: 361077
is version of: GO:0008054
fast: false
reversible: false
name: cyclin degradation

361077
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000042
type: Species
in compartment: metaid_0000041
has only substance units: false
is version of: GO:0016538
name: cyclin
initial amount: 0.01
boundary condition: false
initial concentration: NaN
is homolog to: P14635
constant: false

metaid_0000009
type: Parameter
constant: true
value: 3.5
name: Bc

metaid_0000029
type: Parameter
constant: true
value: 0.7
name: vM4

metaid_0000010
type: Parameter
constant: true
value: 0.2
name: kd

metaid_0000064
type: Reaction
kinetic law: 361342
product: 361330
reactant: 361318
is version of: GO:0016311
fast: false
reversible: false
name: cdc25 dephosphorylation

361330
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

361318
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000017
type: Parameter
constant: true
value: 0.55
name: v'M1

metaid_0000040
type: Parameter
constant: true
value: 1.1
name: totcdk

metaid_0000027
type: Parameter
constant: true
value: 1.0
name: v'M3

metaid_0000060
type: Reaction
kinetic law: 361150
modifier: 361138
product: 361126
reactant: 361113
is version of: REACT 6914.2
fast: false
reversible: false
name: MPF cyclin subunit degradation

361126
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

361113
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000058
type: Reaction
kinetic law: 361065
product: 361053
reactant: 361040
reactant: 361028
is version of: REACT 6216.2
fast: false
reversible: false
name: cyclin/cdk complex formation

361053
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

361040
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

361028
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000015
type: Parameter
constant: true
value: 0.01
name: j1

metaid_0000035
type: Parameter
constant: true
value: 0.01
name: mu

metaid_0000014
type: Parameter
constant: true
value: 0.5
name: Ka

metaid_0000008
type: Parameter
constant: true
value: 0.05
name: kc

metaid_0000034
type: Parameter
constant: true
value: 0.01
name: j'4

metaid_0000028
type: Parameter
constant: true
value: 1.0
name: B3

metaid_0000007
type: Parameter
constant: true
value: 1.0
name: kf

metaid_0000022
type: Parameter
constant: true
value: 1.0
name: v'M2

metaid_0000063
type: Reaction
product: 361270
is version of: REACT 2119.3
name: cdc25 phosphorylation
fast: false
modifier: 361282
reactant: 361258
modifier: 361294
reversible: false
kinetic law: 361306
is version of: GO:0016310

361270
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

361258
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000021
type: Parameter
constant: true
value: 0.01
name: j2

metaid_0000069
type: Reaction
kinetic law: 361559
product: 361547
is version of: GO:0016049
fast: false
reversible: false
name: cell growth

361547
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

metaid_0000070
type: Event
event assignment: 361583
trigger: 361571
is version of: GO:0051301
use values from trigger time: true
name: cell_division

361571
type: Trigger
persistant: true
initial value: true

metaid_0000057
type: Reaction
kinetic law: 361016
product: 361004
is version of: GO:0010467
fast: false
reversible: false
name: cyclin synthesis

361004
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000038
type: Parameter
constant: true
value: 1.0
name: totwee1

metaid_0000030
type: Parameter
constant: true
value: 2.0
name: a4

metaid_0000026
type: Parameter
constant: true
value: 0.01
name: j3

W3 CDTF: Mon Oct 13 13:53:24 BST 2008

ORG:
  orgname: Indiana University School of Informatics, USA
n:
  given: Srividhya
  family: Jeyaram

W3 CDTF: Thu Sep 08 13:12:00 BST 2011

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah