BIOMD0000000194
type: SBMLModel
compartment: metaid_0000014
is version of: REACT 2137.2
units def: metaid_0000042
units def: metaid_0000043
is part of: hsa04110
species: metaid_0000016
notes: Biophysical Chemistry 134 (2008) 93-100 Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study) Bashar Ibrahim, Peter Dittrich, Stephan Diekmann, Eberhard Schmitt This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
creator:
  ORG:
    orgname: German Cancer Research Center, Heidelberg
  n:
    given: Bashar
    family: Ibrahim
volume units: metaid_0000004
area units: metaid_0000005
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Eberhard
    family: Schmitt
parameter: metaid_0000008
reaction: metaid_0000023
parameter: metaid_0000044
substance units: metaid_0000040
reaction: metaid_0000024
creator:
  ORG:
    orgname: Friedrich-Schiller-University Jena, Germany
  n:
    given: Peter
    family: Dittrich
species: metaid_0000018
species: metaid_0000015
event: metaid_0000031
curated: true
created:
  W3 CDTF: Thu Sep 11 21:58:11 BST 2008
modified:
  W3 CDTF: Wed Sep 23 18:09:50 BST 2009
time units: metaid_0000008
is: MODEL1667525941
parameter: metaid_0000009
parameter: metaid_0000045
reaction: metaid_0000025
parameter: metaid_0000007
occurs in: http://identifiers.org/taxonomy/9606
parameter: metaid_0000003
species: metaid_0000017
is version of: GO:0007094
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Stephan
    family: Diekmann
is described by: http://identifiers.org/pubmed/18295960
species: metaid_0000019
parameter: metaid_0000010
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
length unit: length
name: Ibrahim2008_Cdc20_Sequestring_Template_Model

metaid_0000014
type: Compartment
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cytoplasm

metaid_0000042
type: SBMLUnitsDef
unit: 333958
name: per second

333958
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

metaid_0000043
type: SBMLUnitsDef
unit: 333994
unit: 333982
unit: 333970
name: liter per mole per second

333994
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

333982
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE

333970
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

metaid_0000016
type: Species
name: O-Mad2
in compartment: metaid_0000014
boundary condition: false
initial concentration: 1.5E-7
constant: false
notes: Open conformation of Mad2
has only substance units: false
is version of: Q13257
substance units: mole
initial amount: NaN

metaid_0000008
type: Parameter
is: SBO:0000036
constant: true
units: metaid_0000043
value: 1.0E9

metaid_0000023
type: Reaction
is version of: GO:0006461
reversible: true
is version of: GO:0032092
product: 334030
reactant: 334006
fast: false
reactant: 334018
is version of: GO:0043241
kinetic law: 334042

334030
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000017
type: Species
has only substance units: false
initial amount: NaN
has part: Q13257
boundary condition: false
initial concentration: 0.0
substance units: mole
has part: Q9Y6D9
constant: false
is: SBO:0000297
in compartment: metaid_0000014
name: Mad1:C-Mad2:O-Mad2*

334006
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

metaid_0000015
type: Species
has part: Q13257
boundary condition: false
name: Mad1:C-Mad2
has part: Q9Y6D9
substance units: mole
initial amount: NaN
initial concentration: 5.0E-8
constant: false
is: SBO:0000297
in compartment: metaid_0000014
has only substance units: false

334018
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000044
type: Parameter
constant: true
units: dimensionless
value: 0.0

metaid_0000024
type: Reaction
reactant: 334067
is version of: GO:0006461
product: 334092
reversible: false
reactant: 334055
kinetic law: 334104
is version of: GO:0032092
fast: false
product: 334080

334067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000018
type: Species
in compartment: metaid_0000014
constant: false
boundary condition: false
initial concentration: 2.2E-7
name: Cdc20
has only substance units: false
is version of: Q12834
initial amount: NaN
substance units: mole

334092
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000019
type: Species
name: Cdc20:C-Mad2
initial concentration: 0.0
substance units: mole
is: SBO:0000297
constant: false
has only substance units: false
in compartment: metaid_0000014
initial amount: NaN
has part: Q12834
has part: Q13257
boundary condition: false

334055
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

334080
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

metaid_0000031
type: Event
event assignment: 334177
trigger: 334165
is: GO:0008608
use values from trigger time: true
name: Microtubule attachment

metaid_0000007
type: Parameter
notes: u = 1 : kinetochore unattached u = 0 : kinetochore attached
constant: false
units: dimensionless
value: 1.0

334165
type: Trigger
persistant: true
initial value: true

metaid_0000009
type: Parameter
is: SBO:0000339
constant: true
units: metaid_0000043
value: 200000.0

metaid_0000045
type: Parameter
constant: true
units: dimensionless
value: 1.0

metaid_0000025
type: Reaction
kinetic law: 334153
product: 334141
product: 334128
reactant: 334116
is version of: GO:0043241
fast: false
reversible: false

334141
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

334128
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

334116
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000003
type: Parameter
is: SBO:0000338
constant: true
units: metaid_0000042
value: 0.01

metaid_0000010
type: Parameter
is: SBO:0000338
constant: true
units: metaid_0000042
value: 0.2