BIOMD0000000192
type: SBMLModel
volume units: metaid_0000004
reaction: 440668
species: 440368
species: 440168
name: Görlich2003_RanGTP_gradient
reaction: 440548
compartment: 440068
length unit: length
is: MODEL4969417017
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
reaction: 440528
units def: metaid_0000041
curated: true
species: 440188
substance units: metaid_0000040
species: 440408
notes: This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2008 The BioModels Team. For more information see the terms of use .
area units: metaid_0000005
created:
  W3 CDTF: Tue Sep 09 15:04:34 BST 2008
species: 440228
species: 440108
is part of: REACT 9507
reaction: 440488
units def: metaid_0000037
species: 440208
creator:
  ORG:
    orgname: ZMBH, INF 282, Heidelberg
  n:
    given: Dirk
    family: Gorlich
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
modified:
  W3 CDTF: Wed Dec 01 22:10:54 GMT 2010
reaction: 440628
species: 440128
reaction: 440508
time units: metaid_0000008
species: 440088
species: 440328
units def: metaid_0000040
reaction: 440568
compartment: 440048
species: 440268
is version of: GO:0008536
reaction: 440630
reaction: 440468
species: 440148
units def: metaid_0000042
units def: metaid_0000043
occurs in: http://identifiers.org/taxonomy/9606
species: 440348
is described by: http://identifiers.org/pubmed/12606574

440668
type: Reaction
kinetic law: 312021
modifier: 312009
product: 311996
reactant: 311984
is version of: GO:0032860
fast: false
reversible: true
name: RanGAP_RanGDP

312046
type: LocalParameter
units: metaid_0000037
value: 0.7
name: Km

metaid_0000037
type: SBMLUnitsDef
unit: 311426
unit: 311414
name: microM

311426
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

311414
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

312034
type: LocalParameter
units: metaid_0000043
value: 10.6
name: kcat

metaid_0000043
type: SBMLUnitsDef
unit: 311402
name: psec

311402
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

440268
type: Species
is: P46060
is version of: IPR000331
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 440068

440068
type: Compartment
is: GO:0005737
constant: true
size: 1.8E-11
spatial dimensions: 3.0

311996
type: SpeciesReference
stoichiometry: 1.0
species: 440408

440408
type: Species
has part: C00035
has part: P62826
constant: false
boundary condition: false
has only substance units: false
initial concentration: 5.0
initial amount: NaN
in compartment: 440068

311984
type: SpeciesReference
stoichiometry: 1.0
species: 440348

440348
type: Species
has part: C00044
has part: P62826
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 440068

440368
type: Species
has part: P43487
initial concentration: 0.0
has only substance units: false
has part: P62826
constant: false
initial amount: NaN
has part: C00044
in compartment: 440068
boundary condition: false

440168
type: Species
has only substance units: false
initial amount: NaN
in compartment: 440048
constant: false
has part: C00044
has part: P18754
initial concentration: 0.0
has part: P62826
boundary condition: false
has part: CHEBI:15996

440048
type: Compartment
is: GO:0005634
constant: true
size: 1.2E-11
spatial dimensions: 3.0

440548
type: Reaction
kinetic law: 311754
product: 311742
reactant: 311730
is version of: GO:0006913
fast: false
reversible: true

311766
type: LocalParameter
units: metaid_0000043
value: 0.03
name: kpermRanGTP

311742
type: SpeciesReference
stoichiometry: 1.0
species: 440348

311730
type: SpeciesReference
stoichiometry: 1.0
species: 440228

440228
type: Species
has part: C00044
has part: P62826
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 440048

440528
type: Reaction
kinetic law: 311693
product: 311681
product: 311669
reactant: 311657
is version of: GO:0043241
fast: false
reversible: true

311718
type: LocalParameter
units: metaid_0000042
value: 100.0
name: r5

metaid_0000042
type: SBMLUnitsDef
unit: 311390
unit: 311378
unit: 311366
name: pmicroMpsec

311390
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

311378
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

311366
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

311705
type: LocalParameter
units: metaid_0000043
value: 55.0
name: r4

311681
type: SpeciesReference
stoichiometry: 1.0
species: 440148

440148
type: Species
is: P18754
is encoded by: ENSG00000180198
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 440048

311669
type: SpeciesReference
stoichiometry: 1.0
species: 440228

311657
type: SpeciesReference
stoichiometry: 1.0
species: 440168

metaid_0000041
type: SBMLUnitsDef
unit: 311354
unit: 311342
unit: 311330
name: microMpsec

311354
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

311342
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

311330
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

440188
type: Species
has part: P62826
has part: P18754
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 440048

311318
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

440108
type: Species
initial concentration: 0.0
has part: CHEBI:17552
has only substance units: false
constant: false
has part: C00035
boundary condition: false
has part: P62826
in compartment: 440048
has part: P18754
initial amount: NaN

440488
type: Reaction
kinetic law: 311546
product: 311534
product: 311522
reactant: 311510
is version of: GO:0005087
fast: false
reversible: true

311570
type: LocalParameter
units: metaid_0000042
value: 11.0
name: r7

311558
type: LocalParameter
units: metaid_0000043
value: 21.0
name: r2

311534
type: SpeciesReference
stoichiometry: 1.0
species: 440128

440128
type: Species
is: C00035
is: CHEBI:17552
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.6
initial amount: NaN
in compartment: 440048

311522
type: SpeciesReference
stoichiometry: 1.0
species: 440188

311510
type: SpeciesReference
stoichiometry: 1.0
species: 440108

440208
type: Species
is: C00044
is: CHEBI:15996
constant: false
boundary condition: true
has only substance units: false
initial concentration: 500.0
initial amount: NaN
in compartment: 440048

440628
type: Reaction
kinetic law: 311864
product: 311852
reactant: 311840
reactant: 311828
is version of: GO:0006461
fast: false
reversible: true

311888
type: LocalParameter
units: metaid_0000043
value: 4.0E-4
name: koff

311876
type: LocalParameter
units: metaid_0000042
value: 0.3
name: kon

311852
type: SpeciesReference
stoichiometry: 1.0
species: 440368

311840
type: SpeciesReference
stoichiometry: 1.0
species: 440328

440328
type: Species
is: P43487
is version of: IPR000156
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 440068

311828
type: SpeciesReference
stoichiometry: 1.0
species: 440348

440508
type: Reaction
kinetic law: 311620
product: 311607
reactant: 311594
reactant: 311582
is version of: GO:0005525
fast: false
reversible: true

311645
type: LocalParameter
units: metaid_0000043
value: 19.0
name: r6

311632
type: LocalParameter
units: metaid_0000042
value: 0.6
name: r3

311607
type: SpeciesReference
stoichiometry: 1.0
species: 440168

311594
type: SpeciesReference
stoichiometry: 1.0
species: 440208

311582
type: SpeciesReference
stoichiometry: 1.0
species: 440188

440088
type: Species
has part: C00035
has part: P62826
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 440048

440568
type: Reaction
kinetic law: 311803
product: 311790
reactant: 311778
is version of: GO:0006913
fast: false
reversible: true

311815
type: LocalParameter
units: metaid_0000043
value: 0.12
name: kpermRanGDP

311790
type: SpeciesReference
stoichiometry: 1.0
species: 440408

311778
type: SpeciesReference
stoichiometry: 1.0
species: 440088

440630
type: Reaction
product: 311924
kinetic law: 311948
reactant: 311900
name: RanBP1_RanGDP
product: 311912
is version of: GO:0043241
modifier: 311936
reversible: true
fast: false

311924
type: SpeciesReference
stoichiometry: 1.0
species: 440328

311972
type: LocalParameter
units: metaid_0000037
value: 0.1
name: Km

311960
type: LocalParameter
units: metaid_0000043
value: 10.8
name: kcat

311900
type: SpeciesReference
stoichiometry: 1.0
species: 440368

311912
type: SpeciesReference
stoichiometry: 1.0
species: 440408

440468
type: Reaction
kinetic law: 311474
product: 311462
reactant: 311450
reactant: 311438
is version of: GO:0006461
fast: false
reversible: true

311498
type: LocalParameter
units: metaid_0000043
value: 55.0
name: r8

311486
type: LocalParameter
units: metaid_0000042
value: 74.0
name: r1

311462
type: SpeciesReference
stoichiometry: 1.0
species: 440108

311450
type: SpeciesReference
stoichiometry: 1.0
species: 440148

311438
type: SpeciesReference
stoichiometry: 1.0
species: 440088