BIOMD0000000190
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is: MODEL6812345601
creator:
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    orgname: University of Malaga
  n:
    given: Miguel A.
    family: Medina
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rule: metaid_0000061
species: metaid_0000044
units def: metaid_0000076
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parameter: metaid_0000034
parameter: metaid_0000021
species: metaid_0000036
creator:
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    orgname: University of Malaga
  n:
    given: Francisca
    family: Sánchez-Jiménez
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units def: metaid_0000056
curated: true
is version of: GO:0006595
species: metaid_0000040
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is described by: http://identifiers.org/pubmed/16709566
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notes: SBML creators: Armando Reyes-Palomares * , Carlos Rodríguez-Caso +, Raul Montañez * , Marta Cascante $, Francisca Sánchez-Jiménez * , Miguel A. Medina * * ProCel Group, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University of Malaga and CIBER de Enfermedades Raras (CIBER-ER). + Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB). $ Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona. http://asp.uma.es Metabolic modeling of polyamine metabolism in mammals. Rodríguez-Caso,C et al.: J Biol Chem 2006 : 281:21799-812. The model reproduces the dynamical behavior of the polyamine metabolism in mammals. In this model there are some additions and corrections to the publication. All perturbations and analysis have produced results very close to the published experiments. The model was successfully tested on CoPaSi v.4.4 (build 26). Parameters not included in the publication: 1. Parameters for SSAT kinetic constants: KmAcCoA = 1.5 µM KmCoA = 40 µM 2. Parameters for equation MAT (table 1): Vmax_MAT = 0.45 µM/min Km_MAT = 41 µM Ki_MET_MAT = 50 µM 3. Erratum.: The corrected ODE for time-dependent variable Antz is: KsANTZ*(1-1/(1+Keq*0.01*([D]+[S])))-KdANTZ*[Antz] According to these modifications the new steady-state analysis results are: Metabolites: [P]= 104.681 µM [D]= 76.7492 µM [S]= 58.0135 µM [SAM]= 52.327 µM [A]= 0.0101962 µM [aS]= 0.0245375 µM [aD]= 0.832236 µM Time-dependent global parameters: [Antz] = 0.574038 µM Vmaxodc = 1.28315 µM/min Vmaxssat = 0.673814 µM/min Vmaxsamdc = 0.36829 µM/min To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedd…
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name: Rodriguez-Caso2006_Polyamine_Metabolism
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    orgname: University of M?laga. CIBERER (Enfermedades Raras)
  n:
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    family: Reyes-Palomares
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created:
  W3 CDTF: Mon Sep 08 16:27:37 BST 2008
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W3 CDTF: Thu Jul 05 15:37:34 BST 2012