BIOMD0000000175
type: SBMLModel
parameter: metaid_0000234
reaction: metaid_0000405
parameter: metaid_0000115
reaction: metaid_0000426
parameter: metaid_0000136
species: metaid_0000360
species: metaid_0000354
parameter: metaid_0000215
reaction: metaid_0000379
species: metaid_0000258
parameter: metaid_0000179
parameter: metaid_0000072
parameter: metaid_0000109
parameter: metaid_0000151
species: metaid_0000333
parameter: metaid_0000172
species: metaid_0000276
parameter: metaid_0000053
reaction: metaid_0000412
species: metaid_0000263
parameter: metaid_0000145
reaction: metaid_0000388
reaction: metaid_0000427
parameter: metaid_0000026
parameter: metaid_0000137
parameter: metaid_0000216
parameter: metaid_0000207
parameter: metaid_0000237
parameter: metaid_0000081
species: metaid_0000348
parameter: metaid_0000118
reaction: metaid_0000421
parameter: metaid_0000173
reaction: metaid_0000442
species: metaid_0000346
species: metaid_0000281
parameter: metaid_0000054
parameter: metaid_0000075
species: metaid_0000327
parameter: metaid_0000154
reaction: metaid_0000462
parameter: metaid_0000027
species: metaid_0000325
parameter: metaid_0000048
parameter: metaid_0000238
species: metaid_0000351
species: metaid_0000301
species: metaid_0000255
parameter: metaid_0000119
species: metaid_0000296
parameter: metaid_0000182
parameter: metaid_0000020
parameter: metaid_0000210
reaction: metaid_0000443
reaction: metaid_0000402
parameter: metaid_0000112
species: metaid_0000330
species: metaid_0000294
parameter: metaid_0000076
parameter: metaid_0000155
parameter: metaid_0000176
species: metaid_0000289
parameter: metaid_0000057
reaction: metaid_0000368
reaction: metaid_0000463
species: metaid_0000317
species: metaid_0000273
parameter: metaid_0000149
species: metaid_0000260
parameter: metaid_0000240
species: metaid_0000309
reaction: metaid_0000403
parameter: metaid_0000085
reaction: metaid_0000364
species: metaid_0000465
rule: metaid_0000466
reaction: metaid_0000385
parameter: metaid_0000113
species: metaid_0000343

metaid_0000234
type: Parameter
constant: true
value: 99.9983
name: koff91

metaid_0000405
type: Reaction
kinetic law: 839115
product: 839103
product: 839091
reactant: 839079
reactant: 839067
fast: false
reversible: true
name: Net Gab1/PI3K binding

839103
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000293

metaid_0000293
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum PI-3K

metaid_0000243
type: Compartment
is: GO:0005886
constant: true
size: 1.0
spatial dimensions: 2.0
name: membrane

839091
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000302

metaid_0000302
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p-PI-3K

839079
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000265

metaid_0000265
type: Species
constant: false
name: PI-3K
has version: P42336
boundary condition: false
has version: Q8WYR1
in compartment: metaid_0000243
initial amount: 46.4
initial concentration: NaN
has only substance units: false

839067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000297

metaid_0000297
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p

metaid_0000115
type: Parameter
constant: true
value: 7.4766
name: kPTP63

metaid_0000426
type: Reaction
kinetic law: 840645
product: 840633
product: 840621
reactant: 840609
reactant: 840597
fast: false
reversible: true
name: Net E13/PI3K Binding

840633
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000293

840621
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000330

metaid_0000330
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-PI-3K

840609
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000265

840597
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000326

metaid_0000326
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB3_p

metaid_0000136
type: Parameter
constant: true
value: 595.8395
name: Kmr82

metaid_0000360
type: Species
is version of: P28562
name: ERKpase
initial amount: 0.0
is described by: http://identifiers.org/omim/602747
boundary condition: false
constant: false
has only substance units: false
is version of: Q16828
is described by: http://identifiers.org/omim/600714
in compartment: metaid_0000243
is version of: Q13115
initial concentration: NaN
is described by: http://identifiers.org/omim/602748

metaid_0000354
type: Species
initial amount: 10.0
initial concentration: NaN
has only substance units: false
constant: false
is version of: http://identifiers.org/omim/142445
name: HRG
boundary condition: false
is version of: Q02297
in compartment: metaid_0000243

metaid_0000215
type: Parameter
constant: true
value: 4.9981
name: koff60

metaid_0000379
type: Reaction
reversible: true
name: Net E11P/RasGAP binding
reactant: 836837
fast: false
product: 836873
kinetic law: 836897
modifier: 836885
reactant: 836849
product: 836861

836837
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000257

metaid_0000257
type: Species
name: E11_p
has part: P00533
boundary condition: false
initial amount: 0.0
initial concentration: NaN
has version: C00562
constant: false
in compartment: metaid_0000243
has only substance units: false

836873
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

metaid_0000294
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum RasGAP

metaid_0000311
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum RasGAP_p

836849
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

metaid_0000266
type: Species
initial concentration: NaN
is version of: IPR001936
is version of: P20936
has only substance units: false
boundary condition: false
initial amount: 93.6
is described by: http://identifiers.org/omim/139150
constant: false
name: RasGAP
in compartment: metaid_0000243

836861
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000271

metaid_0000271
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-RasGAP

metaid_0000258
type: Species
has part: P00533
has part: P04626
has only substance units: false
boundary condition: false
has version: C00562
initial concentration: NaN
initial amount: 0.0
name: E12_p
in compartment: metaid_0000243
constant: false

metaid_0000179
type: Parameter
constant: true
value: 0.0138
name: kon23

metaid_0000072
type: Parameter
constant: true
value: 5.5425
name: koff9

metaid_0000109
type: Parameter
constant: true
value: 29.8531
name: kPTP10

metaid_0000151
type: Parameter
constant: true
value: 0.0038
name: kon86

metaid_0000333
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-Shc

metaid_0000172
type: Parameter
constant: true
value: 0.0117
name: kon18

metaid_0000276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-Shc

metaid_0000053
type: Parameter
constant: true
value: 336.183
name: Kmr54

metaid_0000412
type: Reaction
kinetic law: 839777
modifier: 839764
product: 839752
reactant: 839740
fast: false
reversible: true
name: Net Raf Activation

metaid_0000310
type: Species
initial concentration: NaN
name: RasGTP
in compartment: metaid_0000243
initial amount: 0.0
constant: false
has version: IPR013753
has part: CHEBI:15996
has only substance units: false
boundary condition: false
has part: P01112

839752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000313

metaid_0000313
type: Species
is version of: C00562
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Raf*

839740
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000312

metaid_0000312
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 743.0
in compartment: metaid_0000243
name: Raf

metaid_0000263
type: Species
initial amount: 82.4
is version of: P62993
boundary condition: false
constant: false
has only substance units: false
in compartment: metaid_0000243
initial concentration: NaN
is described by: http://identifiers.org/omim/108355
name: Grb2

metaid_0000145
type: Parameter
constant: true
value: 6.7591
name: kf85

metaid_0000388
type: Reaction
reversible: true
name: Net E34P/Shc binding
reactant: 837572
fast: false
modifier: 837634
kinetic law: 837646
modifier: 837621
product: 837609
reactant: 837584
product: 837597

837572
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000260

metaid_0000260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34_p

metaid_0000300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Shc_p-Grb2

metaid_0000296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Shc_p

837609
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

metaid_0000292
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Shc

837584
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

metaid_0000264
type: Species
constant: false
is described by: http://identifiers.org/omim/605217
has only substance units: false
name: Shc
boundary condition: false
initial amount: 11.5
is version of: P98077
in compartment: metaid_0000243
initial concentration: NaN

837597
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000280

metaid_0000280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-Shc

metaid_0000427
type: Reaction
reactant: 840657
modifier: 840705
product: 840681
fast: false
kinetic law: 840717
reversible: true
name: Net E13/RasGAP Binding
product: 840693
reactant: 840669

840657
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000326

840681
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000331

metaid_0000331
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-RasGAP

840693
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

840669
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

metaid_0000026
type: Parameter
constant: true
value: 16.833
name: kf48

metaid_0000137
type: Parameter
constant: true
value: 1.7628
name: kf83

metaid_0000216
type: Parameter
constant: true
value: 5.229
name: koff61

metaid_0000207
type: Parameter
constant: true
value: 0.0122
name: kon44

metaid_0000237
type: Parameter
constant: true
value: 100.0037
name: koff93

metaid_0000081
type: Parameter
constant: true
value: 2.3619
name: koff23

metaid_0000348
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E4_p-PTP-1B

metaid_0000118
type: Parameter
constant: true
value: 1.2496
name: koff74

metaid_0000421
type: Reaction
kinetic law: 840307
product: 840295
reactant: 840283
reactant: 840271
fast: false
reversible: true
name: ErbB1/ErbB4 Heterodimerization

840295
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000325

metaid_0000325
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB4

840283
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000248

metaid_0000248
type: Species
constant: false
initial amount: 0.0
has part: P01133
has part: P00533
has only substance units: false
name: EGF-ErbB1
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000243

840271
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000250

metaid_0000250
type: Species
name: HRG-ErbB4
has part: Q15303
in compartment: metaid_0000243
has only substance units: false
has part: Q02297
initial concentration: NaN
initial amount: 0.0
boundary condition: false
constant: false

metaid_0000173
type: Parameter
constant: true
value: 0.0116
name: kon73

metaid_0000442
type: Reaction
kinetic law: 841659
modifier: 841647
product: 841635
reactant: 841623
fast: false
reversible: true
name: Net E4 S/T Phosphorylation

metaid_0000317
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ERK*

841635
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000348

841623
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000247

metaid_0000247
type: Species
is version of: Q15303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 399.0
in compartment: metaid_0000243
name: ErbB4

metaid_0000346
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E1_p-PTP-1B

metaid_0000281
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-PI-3K

metaid_0000054
type: Parameter
constant: true
value: 0.2256
name: kf55

metaid_0000075
type: Parameter
constant: true
value: 4.6874
name: koff17

metaid_0000327
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB3_p

metaid_0000154
type: Parameter
constant: true
value: 8.0E-4
name: kon87

metaid_0000462
type: Reaction
kinetic law: 842752
product: 842740
reactant: 842727
reactant: 842715
fast: false
reversible: true
name: pERK binding to Phosphatase

842740
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000359

metaid_0000359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: p_ERK-ERKpase

842727
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000360

842715
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000356

metaid_0000356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: p_ERK

metaid_0000027
type: Parameter
constant: true
value: 715.5688
name: Kmf48

metaid_0000048
type: Parameter
constant: true
value: 812.254
name: Kmf53

metaid_0000238
type: Parameter
constant: true
value: 0.9966
name: kcat94

metaid_0000351
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Aktstar

metaid_0000301
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p-Shc

metaid_0000255
type: Species
has only substance units: false
in compartment: metaid_0000243
has part: P04626
has part: Q02297
has part: Q15303
constant: false
initial concentration: NaN
initial amount: 0.0
name: HRG-Erb4-ErbB2
boundary condition: false

metaid_0000119
type: Parameter
constant: true
value: 1.4323
name: koff75

metaid_0000182
type: Parameter
constant: true
value: 0.0137
name: kon75

metaid_0000020
type: Parameter
constant: true
value: 486.1398
name: KmPY

metaid_0000210
type: Parameter
constant: true
value: 0.0148
name: kon46

metaid_0000443
type: Reaction
kinetic law: 841707
modifier: 841695
product: 841683
reactant: 841671
fast: false
reversible: true
name: Net E_E1 S/T Phosphorylation

841683
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000349

metaid_0000349
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E_E1_p-PTP-1B

841671
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000248

metaid_0000402
type: Reaction
modifier: 838862
reactant: 838778
product: 838802
modifier: 838814
product: 838790
modifier: 838850
reactant: 838766
reversible: true
modifier: 838826
fast: false
kinetic law: 838874
modifier: 838838
name: Net Grb2/Gab1 binding

metaid_0000352
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: SumGab1_p-PTP-1B

838778
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000268

metaid_0000268
type: Species
is version of: Q13480
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: false
name: Gab1
in compartment: metaid_0000243
is described by: http://identifiers.org/omim/604439
initial amount: 43.1

838802
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000295

metaid_0000295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1

838790
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000299

metaid_0000299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Grb2-Gab1

838766
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

metaid_0000291
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Grb2

metaid_0000303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p-RasGAP

metaid_0000112
type: Parameter
constant: true
value: 55.2104
name: kPTP13

metaid_0000076
type: Parameter
constant: true
value: 2.2768
name: koff18

metaid_0000155
type: Parameter
constant: true
value: 0.5005
name: kon4

metaid_0000176
type: Parameter
constant: true
value: 0.0114
name: kon21

metaid_0000289
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-PI-3K

metaid_0000057
type: Parameter
constant: true
value: 643.9247
name: Kmr55

metaid_0000368
type: Reaction
kinetic law: 836258
product: 836245
reactant: 836233
reactant: 836221
is version of: GO:0046983
fast: false
reversible: true
name: ErbB3/ErbB4 Heterodimerization

836245
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000254

metaid_0000254
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: false
has part: P21860
has part: Q02297
has part: Q15303
constant: false
initial amount: 0.0
in compartment: metaid_0000243
name: (HRG-ErbB3/4)2

836233
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000250

836221
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000249

metaid_0000249
type: Species
constant: false
initial amount: 0.0
has only substance units: false
name: HRG-ErbB3
boundary condition: false
has part: P21860
initial concentration: NaN
in compartment: metaid_0000243
has part: Q02297

metaid_0000463
type: Reaction
kinetic law: 842800
product: 842788
product: 842776
reactant: 842764
fast: false
reversible: false
name: pERK dephosphorylation

842788
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000360

842776
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000316

metaid_0000316
type: Species
in compartment: metaid_0000243
initial concentration: NaN
boundary condition: false
is version of: P28482
is described by: http://identifiers.org/omim/176948
name: ERK
constant: false
has only substance units: false
initial amount: 750.0

842764
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000359

metaid_0000273
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-Shc

metaid_0000149
type: Parameter
constant: true
value: 9.9783
name: kcon49

metaid_0000240
type: Parameter
constant: true
value: 100.0023
name: koff95

metaid_0000309
type: Species
constant: false
is version of: IPR013753
has part: P01112
in compartment: metaid_0000243
has part: CHEBI:17552
initial concentration: NaN
name: RasGDP
initial amount: 95.7
boundary condition: false
has only substance units: false

metaid_0000403
type: Reaction
fast: false
kinetic law: 838970
product: 838910
name: Net Shc/Grb2 binding
modifier: 838958
reversible: true
modifier: 838946
modifier: 838934
reactant: 838886
product: 838922
reactant: 838898

838910
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species: metaid_0000300

metaid_0000320
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initial concentration: NaN
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metaid_0000298
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boundary condition: false
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initial concentration: NaN
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name: Sum Grb2-SOS

838886
type: SpeciesReference
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species: metaid_0000296

838922
type: SpeciesReference
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species: metaid_0000291

838898
type: SpeciesReference
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species: metaid_0000263

metaid_0000085
type: Parameter
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value: 1.8922
name: koff27

metaid_0000364
type: Reaction
kinetic law: 836065
modifier: 836053
product: 836041
reactant: 836029
fast: false
reversible: true
name: HRG Binding to ErbB4

836041
type: SpeciesReference
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species: metaid_0000250

836029
type: SpeciesReference
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species: metaid_0000247

metaid_0000465
type: Species
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boundary condition: true
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initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000243
name: normalized Erk*

metaid_0000385
type: Reaction
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product: 837379
product: 837367
reactant: 837354
reactant: 837342
fast: false
reversible: true
name: Net E23P/PI3K binding

837379
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000293

837367
type: SpeciesReference
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species: metaid_0000277

metaid_0000277
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
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name: E23-PI-3K

837354
type: SpeciesReference
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species: metaid_0000265

837342
type: SpeciesReference
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species: metaid_0000259

metaid_0000259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23_p

metaid_0000113
type: Parameter
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value: 57.7506
name: kPTP14

metaid_0000343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-PTP-1B

metaid_0000213
type: Parameter
constant: true
value: 1.1994E-4
name: kon60

metaid_0000177
type: Parameter
constant: true
value: 0.0133
name: kon74

metaid_0000446
type: Reaction
kinetic law: 841858
modifier: 841845
product: 841832
reactant: 841819
fast: false
reversible: true
name: HRG binding to E4-PT

841832
type: SpeciesReference
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species: metaid_0000350

metaid_0000350
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
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name: H_E4_p-PTP-1B

841819
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000348

metaid_0000058
type: Parameter
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value: 279.9929
name: kf38

metaid_0000079
type: Parameter
constant: true
value: 4.7291
name: koff21

metaid_0000158
type: Parameter
constant: true
value: 1.0606
name: kon7

metaid_0000322
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum PIP3-Gab1-Grb2_SOS

metaid_0000030
type: Parameter
constant: true
value: 44.3501
name: kf49

metaid_0000051
type: Parameter
constant: true
value: 588.2671
name: Vmaxr54

metaid_0000383
type: Reaction
modifier: 837235
reactant: 837163
modifier: 837223
kinetic law: 837247
product: 837199
reversible: true
modifier: 837211
reactant: 837175
fast: false
name: Net E23P/Grb2 binding
product: 837187

837163
type: SpeciesReference
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species: metaid_0000259

837199
type: SpeciesReference
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species: metaid_0000291

837175
type: SpeciesReference
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species: metaid_0000263

837187
type: SpeciesReference
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species: metaid_0000275

metaid_0000275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-Grb2

metaid_0000241
type: Parameter
constant: true
value: 19.9851
name: kcat96

metaid_0000252
type: Species
name: EGF-ErbB1-ErbB2
initial amount: 0.0
initial concentration: NaN
has only substance units: false
has part: P00533
has part: P01133
boundary condition: false
in compartment: metaid_0000243
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constant: false

metaid_0000122
type: Parameter
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value: 0.2007
name: koff78

metaid_0000314
type: Species
is version of: Q02750
in compartment: metaid_0000243
is described by: http://identifiers.org/omim/176872
initial concentration: NaN
initial amount: 772.0
is version of: A4QPA9
constant: false
name: MEK
has only substance units: false
boundary condition: false

metaid_0000386
type: Reaction
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product: 837440
modifier: 837452
reversible: true
kinetic law: 837464
reactant: 837416
reactant: 837404
product: 837428
name: Net E23P/RasGAP binding

837440
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

837416
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

837404
type: SpeciesReference
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species: metaid_0000259

837428
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000278

metaid_0000278
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-RasGAP

metaid_0000024
type: Parameter
constant: true
value: 698.6022
name: Kmf47

metaid_0000186
type: Parameter
constant: true
value: 0.0346
name: kon29

metaid_0000214
type: Parameter
constant: true
value: 33.3
name: VeVc

metaid_0000447
type: Reaction
kinetic law: 841925
product: 841912
product: 841899
reactant: 841886
reactant: 841872
fast: false
reversible: true
name: PTP1B binding to SigAP

841912
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

metaid_0000345
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sig-PTP-1B

841899
type: SpeciesReference
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species: metaid_0000352

841886
type: SpeciesReference
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species: metaid_0000336

metaid_0000336
type: Species
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initial concentration: NaN
initial amount: 500.0
is described by: http://identifiers.org/omim/176885
has only substance units: false
is version of: P18031
constant: false
name: PTP-1B
in compartment: metaid_0000243

841872
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000297

metaid_0000406
type: Reaction
reversible: true
product: 839163
reactant: 839139
modifier: 839175
fast: false
name: Net Gab1/RasGAP binding
product: 839151
reactant: 839127
kinetic law: 839187

839163
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

839139
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

839151
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000303

839127
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000297

metaid_0000116
type: Parameter
constant: true
value: 48.6335
name: kPTP64

metaid_0000159
type: Parameter
constant: true
value: 1.0259
name: kon8

metaid_0000392
type: Reaction
modifier: 837947
product: 837923
modifier: 837935
reactant: 837887
name: Net E24P/Shc binding
fast: false
product: 837911
reversible: true
kinetic law: 837959
reactant: 837899

837923
type: SpeciesReference
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species: metaid_0000292

837887
type: SpeciesReference
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species: metaid_0000261

metaid_0000261
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24_p

837911
type: SpeciesReference
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species: metaid_0000284

metaid_0000284
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-Shc

837899
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

metaid_0000270
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-Shc

metaid_0000052
type: Parameter
constant: true
value: 457.9645
name: Kmf54

metaid_0000152
type: Parameter
constant: true
value: 0.0059
name: kon2

metaid_0000033
type: Parameter
constant: true
value: 753.1667
name: Kmr49

metaid_0000306
type: Species
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initial concentration: NaN
in compartment: metaid_0000243
name: PIP2
has only substance units: false
is: C04637
is: CHEBI:28910
initial amount: 197.0
boundary condition: false

metaid_0000223
type: Parameter
constant: true
value: 0.0116
name: kon70

metaid_0000460
type: Reaction
kinetic law: 842655
product: 842643
reactant: 842631
reactant: 842619
fast: false
reversible: true
name: ERKstar binding to Phosphatase

842643
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000361

metaid_0000361
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 35.0
in compartment: metaid_0000243
name: ERK*-ERKpase

842631
type: SpeciesReference
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species: metaid_0000360

842619
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000317

metaid_0000089
type: Parameter
constant: true
value: 1.2204
name: koff31

metaid_0000407
type: Reaction
modifier: 839247
modifier: 839295
kinetic law: 839307
fast: false
reactant: 839211
modifier: 839259
name: Net Gab1/PIP3 binding
modifier: 839271
reactant: 839199
modifier: 839283
product: 839223
product: 839235
reversible: true

839211
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000268

839199
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000307

metaid_0000307
type: Species
initial amount: 0.0
boundary condition: false
has only substance units: false
initial concentration: NaN
is: CHEBI:16618
in compartment: metaid_0000243
constant: false
is: C05981
name: PIP3

839223
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000305

metaid_0000305
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: PIP3-Gab1

839235
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000295

metaid_0000340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-PTP-1B

metaid_0000389
type: Reaction
kinetic law: 837706
product: 837694
product: 837682
reactant: 837670
reactant: 837658
fast: false
reversible: true
name: Net E34P/PI3K binding

837694
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000293

837682
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000281

837670
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000265

837658
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000260

metaid_0000117
type: Parameter
constant: true
value: 3.0048
name: koff73

metaid_0000428
type: Reaction
product: 840754
name: Net E14/Grb2 Binding
reactant: 840741
modifier: 840790
reversible: true
modifier: 840778
reactant: 840729
modifier: 840802
fast: false
kinetic law: 840814
product: 840766

840754
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000332

metaid_0000332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-Grb2

840741
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

840729
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000327

840766
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

metaid_0000180
type: Parameter
constant: true
value: 0.005
name: kon24

metaid_0000217
type: Parameter
constant: true
value: 0.8048
name: kon61

metaid_0000208
type: Parameter
constant: true
value: 0.0028
name: kon45

metaid_0000061
type: Parameter
constant: true
value: 0.0849
name: a98

metaid_0000337
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-PTP-1B

metaid_0000082
type: Parameter
constant: true
value: 4.4226
name: koff24

metaid_0000393
type: Reaction
kinetic law: 838019
product: 838007
product: 837995
reactant: 837983
reactant: 837971
fast: false
reversible: true
name: Net E24P/PI3K binding

838007
type: SpeciesReference
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species: metaid_0000293

837995
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000285

metaid_0000285
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-PI-3K

837983
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000265

837971
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000261

metaid_0000153
type: Parameter
constant: true
value: 0.0334
name: kon3

metaid_0000422
type: Reaction
kinetic law: 840355
modifier: 840343
product: 840331
reactant: 840319
fast: false
reversible: true
name: Net E13 Phosphorylation

840331
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000326

840319
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000324

metaid_0000324
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB3

metaid_0000335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-RasGAP

metaid_0000034
type: Parameter
constant: true
value: 381.2208
name: Kmr49b

metaid_0000055
type: Parameter
constant: true
value: 646.9003
name: Vmaxr55

metaid_0000126
type: Parameter
constant: true
value: 79.6132
name: kPTP39

metaid_0000437
type: Reaction
kinetic law: 841393
product: 841381
product: 841369
reactant: 841357
reactant: 841345
fast: false
reversible: true
name: Net E44/PTP1B Binding

841381
type: SpeciesReference
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species: metaid_0000345

841369
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000342

metaid_0000342
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-PTP-1B

841357
type: SpeciesReference
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species: metaid_0000336

841345
type: SpeciesReference
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species: metaid_0000262

metaid_0000262
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44_p

metaid_0000028
type: Parameter
constant: true
value: 324.9294
name: Kmr48

metaid_0000218
type: Parameter
constant: true
value: 1.782
name: kon62

metaid_0000209
type: Parameter
constant: true
value: 0.0108
name: kon88

metaid_0000244
type: Species
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: 274.0
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name: ErbB1

metaid_0000362
type: Reaction
kinetic law: 835969
modifier: 835957
product: 835945
reactant: 835932
is version of: GO:0006461
fast: false
reversible: true
name: EGF Binding to ErbB1

metaid_0000353
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initial amount: 10.0
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name: EGF
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constant: false
in compartment: metaid_0000243

835945
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000248

835932
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000244

metaid_0000083
type: Parameter
constant: true
value: 2.225
name: koff25

metaid_0000162
type: Parameter
constant: true
value: 0.6496
name: kf10

metaid_0000183
type: Parameter
constant: true
value: 0.0355
name: kon26

metaid_0000423
type: Reaction
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modifier: 840391
product: 840379
reactant: 840367
fast: false
reversible: true
name: Net E14 Phosphorylation

840379
type: SpeciesReference
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species: metaid_0000327

840367
type: SpeciesReference
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species: metaid_0000325

metaid_0000444
type: Reaction
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modifier: 841743
product: 841731
reactant: 841719
fast: false
reversible: true
name: Net H_E4 S/T Phosphorylation

841731
type: SpeciesReference
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species: metaid_0000350

841719
type: SpeciesReference
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species: metaid_0000250

metaid_0000283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-Grb2

metaid_0000056
type: Parameter
constant: true
value: 460.9446
name: Kmf55

metaid_0000156
type: Parameter
constant: true
value: 2.5427
name: kon5

metaid_0000438
type: Reaction
kinetic law: 841454
product: 841442
product: 841430
reactant: 841418
reactant: 841405
fast: false
reversible: true
name: Net E13/PTP1B Binding

841442
type: SpeciesReference
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species: metaid_0000345

841430
type: SpeciesReference
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species: metaid_0000343

841418
type: SpeciesReference
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species: metaid_0000336

841405
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000326

metaid_0000037
type: Parameter
constant: true
value: 0.0
name: kr51

metaid_0000369
type: Reaction
kinetic law: 836306
product: 836294
reactant: 836282
reactant: 836270
is version of: GO:0046983
fast: false
reversible: true
name: ErbB2/ErbB4 Heterodimerization

836294
type: SpeciesReference
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species: metaid_0000255

836282
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000245

metaid_0000245
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: 158.0
in compartment: metaid_0000243
name: ErbB2

836270
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000250

metaid_0000227
type: Parameter
constant: true
value: 0.0355
name: kon72

metaid_0000440
type: Reaction
kinetic law: 841563
modifier: 841551
product: 841539
reactant: 841527
fast: false
reversible: true
name: Net E1 S/T Phosphorylation

841539
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000346

841527
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000244

metaid_0000120
type: Parameter
constant: true
value: 2.1542
name: koff76

metaid_0000220
type: Parameter
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value: 0.0045
name: kon68

metaid_0000184
type: Parameter
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value: 0.0201
name: kon27

metaid_0000065
type: Parameter
constant: true
value: 9.0E-4
name: HRGoff_3

metaid_0000086
type: Parameter
constant: true
value: 4.6432
name: koff28

metaid_0000365
type: Reaction
kinetic law: 836113
product: 836101
reactant: 836089
reactant: 836077
is version of: GO:0046983
fast: false
reversible: true
name: ErbB1 Dimerization

836101
type: SpeciesReference
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species: metaid_0000251

metaid_0000251
type: Species
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name: (EGF-ErbB1)2
initial concentration: NaN
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in compartment: metaid_0000243
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boundary condition: false
has part: P00533
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836089
type: SpeciesReference
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species: metaid_0000248

836077
type: SpeciesReference
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species: metaid_0000248

metaid_0000404
type: Reaction
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fast: false
product: 839019
modifier: 839043
reactant: 838994
name: Net Gab1/Shc binding
reactant: 838982
modifier: 839031
product: 839007
kinetic law: 839055

839019
type: SpeciesReference
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species: metaid_0000292

838994
type: SpeciesReference
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species: metaid_0000264

838982
type: SpeciesReference
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species: metaid_0000297

839007
type: SpeciesReference
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species: metaid_0000301

metaid_0000157
type: Parameter
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value: 0.2283
name: kon6

metaid_0000038
type: Parameter
constant: true
value: 16.737
name: Vmaxr51

metaid_0000390
type: Reaction
kinetic law: 837778
fast: false
reversible: true
product: 837742
name: Net E34P/RasGAP binding
product: 837754
reactant: 837730
modifier: 837766
reactant: 837718

837742
type: SpeciesReference
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species: metaid_0000282

metaid_0000282
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-RasGAP

837754
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

837730
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

837718
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000260

metaid_0000059
type: Parameter
constant: true
value: 385.7428
name: kf39

metaid_0000319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Gab1_p

metaid_0000010
type: Parameter
constant: true
value: 93.6
name: RasGAP_Abund

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000031
type: Parameter
constant: true
value: 552.6746
name: kr49

W3 CDTF: Tue Apr 21 21:13:48 BST 2009

metaid_0000221
type: Parameter
constant: true
value: 0.0084
name: kon69

metaid_0000242
type: Parameter
constant: true
value: 35.005
name: ERKPpase_Abund

metaid_0000102
type: Parameter
constant: true
value: 0.5441
name: koff43

metaid_0000413
type: Reaction
kinetic law: 839825
modifier: 839813
product: 839801
reactant: 839789
fast: false
reversible: true
name: Net MEK Activation

839801
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000315

metaid_0000315
type: Species
constant: false
is version of: A4QPA9
initial amount: 0.0
in compartment: metaid_0000243
is version of: Q02750
has only substance units: false
initial concentration: NaN
is described by: http://identifiers.org/omim/176872
boundary condition: false
is version of: C00562
name: MEK*

839789
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000314

metaid_0000123
type: Parameter
constant: true
value: 1.1852
name: koff79

metaid_0000087
type: Parameter
constant: true
value: 2.0148
name: koff29

metaid_0000366
type: Reaction
kinetic law: 836161
product: 836149
reactant: 836137
reactant: 836125
is version of: GO:0046983
fast: false
reversible: true
name: ErbB1/ErbB2 Heterodimerization

836149
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000252

836137
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000245

836125
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000248

metaid_0000166
type: Parameter
constant: true
value: 6.1726
name: kf14

metaid_0000387
type: Reaction
modifier: 837536
product: 837512
reversible: true
modifier: 837524
fast: false
name: Net E34P/Grb2 binding
kinetic law: 837560
modifier: 837548
product: 837500
reactant: 837488
reactant: 837476

837512
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

837500
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000279

metaid_0000279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-Grb2

837488
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

837476
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000260

metaid_0000187
type: Parameter
constant: true
value: 0.0053
name: kon76

metaid_0000468
type: SBMLUnitsDef
unit: 835920
name: nanomole

835920
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000448
type: Reaction
kinetic law: 841964
product: 841951
reactant: 841938
fast: false
reversible: false
name: E11P Degradation

841951
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000304

metaid_0000304
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Empty

841938
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000257

metaid_0000080
type: Parameter
constant: true
value: 3.6962
name: koff22

metaid_0000391
type: Reaction
product: 837826
name: Net E24P/Grb2 binding
modifier: 837862
fast: false
reactant: 837790
reactant: 837802
modifier: 837850
modifier: 837838
kinetic law: 837874
product: 837814
reversible: true

837826
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

837790
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000261

837802
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

837814
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000283

W3 CDTF: Thu Jul 17 14:46:08 BST 2008

metaid_0000420
type: Reaction
kinetic law: 840259
product: 840247
reactant: 840235
reactant: 840223
fast: false
reversible: true
name: ErbB1/ErbB3 Heterodimerization

840247
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000324

840235
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000248

840223
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000249

metaid_0000032
type: Parameter
constant: true
value: 343.2483
name: Kmf49

metaid_0000414
type: Reaction
kinetic law: 839873
modifier: 839861
product: 839849
reactant: 839837
fast: false
reversible: true
name: Net SOS S/T Phosphorylation

839849
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000318

metaid_0000318
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: SOS_p

839837
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000267

metaid_0000267
type: Species
initial concentration: NaN
boundary condition: false
name: SOS
is described by: http://identifiers.org/omim/182530
constant: false
has only substance units: false
initial amount: 82.3
in compartment: metaid_0000243
is version of: Q07889

metaid_0000013
type: Parameter
constant: true
value: 197.0
name: PIP2_Abund

metaid_0000396
type: Reaction
fast: false
name: Net E44P/Shc binding
product: 838224
kinetic law: 838272
reversible: true
product: 838236
modifier: 838260
modifier: 838248
reactant: 838199
reactant: 838212

838224
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000288

metaid_0000288
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-Shc

838236
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

838199
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000262

838212
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

metaid_0000124
type: Parameter
constant: true
value: 2.9373
name: koff80

metaid_0000203
type: Parameter
constant: true
value: 0.0191
name: kon40

metaid_0000005
type: Parameter
constant: true
value: 294.0
name: ErbB3_Abund

metaid_0000224
type: Parameter
constant: true
value: 2.6069
name: koff70

metaid_0000188
type: Parameter
constant: true
value: 0.002
name: kon30

metaid_0000069
type: Parameter
constant: true
value: 2.6619
name: koff6

metaid_0000453
type: Reaction
kinetic law: 842211
product: 842198
reactant: 842185
fast: false
reversible: false
name: 1-1 Dimer Internalization Fraction

842198
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000355

metaid_0000355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: fint

842185
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000304

metaid_0000408
type: Reaction
kinetic law: 839355
modifier: 839343
product: 839331
reactant: 839319
fast: false
reversible: true
name: Net Akt Activation

839331
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000351

839319
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000308

metaid_0000308
type: Species
in compartment: metaid_0000243
is described by: http://identifiers.org/omim/611223
has only substance units: false
constant: false
initial concentration: NaN
initial amount: 444.0
name: Akt
boundary condition: false
is version of: Q9Y243

metaid_0000274
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-RasGAP

metaid_0000160
type: Parameter
constant: true
value: 2.2868
name: kon9

metaid_0000181
type: Parameter
constant: true
value: 0.0995
name: kon25

metaid_0000041
type: Parameter
constant: true
value: 988.4496
name: Kmrb51

metaid_0000062
type: Parameter
constant: true
value: 0.1833
name: b98

metaid_0000394
type: Reaction
product: 838055
reactant: 838031
modifier: 838079
fast: false
reactant: 838043
reversible: true
product: 838067
kinetic law: 838091
name: Net E24P/RasGAP binding

838055
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000286

metaid_0000286
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-RasGAP

838031
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000261

838043
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

838067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

metaid_0000272
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-Grb2

metaid_0000014
type: Parameter
constant: true
value: 444.2921
name: Akt_Abund

metaid_0000397
type: Reaction
kinetic law: 838332
product: 838320
product: 838308
reactant: 838296
reactant: 838284
fast: false
reversible: true
name: Net E44P/PI3K binding

838320
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000293

838308
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000289

838296
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000265

838284
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000262

metaid_0000035
type: Parameter
constant: true
value: 640.8212
name: kr49b

metaid_0000225
type: Parameter
constant: true
value: 0.0078
name: kon71

metaid_0000417
type: Reaction
kinetic law: 840030
product: 840018
product: 840006
reactant: 839994
reactant: 839981
fast: false
reversible: true
name: SOS binding to SigA-G

840018
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000323

metaid_0000323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum SOS

840006
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000322

839994
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000267

839981
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000321

metaid_0000321
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum PIP3-Gab1-Grb2

metaid_0000464
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000243
name: normalized Akt*

metaid_0000106
type: Parameter
constant: true
value: 9.172
name: koff59

metaid_0000090
type: Parameter
constant: true
value: 3.8752
name: koff32

metaid_0000127
type: Parameter
constant: true
value: 3.9255
name: koff88

metaid_0000454
type: Reaction
modifier: 842276
kinetic law: 842302
modifier: 842289
modifier: 842250
reactant: 842224
modifier: 842263
name: EGF in EC compartment
product: 842237
reversible: true
fast: false

842224
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000353

842237
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000304

metaid_0000190
type: Parameter
constant: true
value: 9.0E-4
name: kon32

metaid_0000430
type: Reaction
kinetic law: 840959
product: 840947
product: 840935
reactant: 840923
reactant: 840911
fast: false
reversible: true
name: Net E14/PI3K Binding

840947
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000293

840935
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000334

metaid_0000334
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-PI-3K

840923
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000265

840911
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000327

metaid_0000358
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: p_ERK-MEK*

metaid_0000063
type: Parameter
constant: true
value: 0.5194
name: koff46

metaid_0000339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-PTP-1B

metaid_0000395
type: Reaction
product: 838127
modifier: 838175
kinetic law: 838187
product: 838139
reactant: 838115
fast: false
reversible: true
reactant: 838103
name: Net E44P/RasGAP binding
modifier: 838151
modifier: 838163

838127
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000287

metaid_0000287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-Grb2

838139
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

838115
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

838103
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000262

metaid_0000142
type: Parameter
constant: true
value: 634.1626
name: Vmaxr84

metaid_0000084
type: Parameter
constant: true
value: 0.0103
name: koff26

metaid_0000363
type: Reaction
kinetic law: 836017
modifier: 836005
product: 835993
reactant: 835981
fast: false
reversible: true
name: HRG Binding to ErbB3

835993
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000249

835981
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000246

metaid_0000246
type: Species
is version of: P21860
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 294.0
in compartment: metaid_0000243
name: ErbB3

metaid_0000163
type: Parameter
constant: true
value: 0.3721
name: kf11

metaid_0000450
type: Reaction
kinetic law: 842068
product: 842055
reactant: 842042
reactant: 842029
fast: false
reversible: false
name: E11S Degradation

842055
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

842042
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

842029
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000270

metaid_0000424
type: Reaction
reactant: 840415
fast: false
reversible: true
product: 840439
kinetic law: 840500
modifier: 840463
modifier: 840487
product: 840451
name: Net E13/Grb2 Binding
modifier: 840475
reactant: 840427

840415
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000326

840439
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000328

metaid_0000328
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-Grb2

840451
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

840427
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

metaid_0000036
type: Parameter
constant: true
value: 3.6515
name: kf51

metaid_0000400
type: Reaction
modifier: 838658
modifier: 838670
reactant: 838561
reversible: true
modifier: 838646
modifier: 838682
fast: false
product: 838574
modifier: 838634
name: Net Gab1 Phosphorylation
modifier: 838610
modifier: 838622
kinetic law: 838694
modifier: 838586
modifier: 838598

838561
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000295

838574
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000297

metaid_0000418
type: Reaction
name: Gab1 binding to SigG-O
kinetic law: 840150
reversible: true
modifier: 840138
modifier: 840102
product: 840066
product: 840078
reactant: 840054
modifier: 840114
reactant: 840042
modifier: 840090
modifier: 840126
fast: false

840066
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000320

840078
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000295

840054
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000268

840042
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000298

metaid_0000017
type: Parameter
constant: true
value: 772.0
name: MEK_Abund

metaid_0000128
type: Parameter
constant: true
value: 96.5716
name: kPTP50

metaid_0000439
type: Reaction
kinetic law: 841515
product: 841503
product: 841490
reactant: 841478
reactant: 841466
fast: false
reversible: true
name: Net E14/PTP1B Binding

841503
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

841490
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000344

metaid_0000344
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-PTP-1B

841478
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000336

841466
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000327

metaid_0000191
type: Parameter
constant: true
value: 0.0335
name: kon33

metaid_0000009
type: Parameter
constant: true
value: 46.4
name: PI3K_Abund

metaid_0000228
type: Parameter
constant: true
value: 0.907
name: koff72

metaid_0000219
type: Parameter
constant: true
value: 5.5142
name: koff62

metaid_0000290
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-RasGAP

metaid_0000372
type: Reaction
kinetic law: 836451
modifier: 836438
product: 836426
reactant: 836414
is version of: GO:0006468
fast: false
reversible: true
name: Net E12 Phosphorylation

836426
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000258

836414
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000252

metaid_0000093
type: Parameter
constant: true
value: 1.8696
name: koff35

metaid_0000100
type: Parameter
constant: true
value: 7.0487
name: koff41

metaid_0000457
type: Reaction
kinetic law: 842510
product: 842498
product: 842486
reactant: 842474
fast: false
reversible: false
name: pERK production

842498
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000315

842486
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000356

842474
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000357

metaid_0000357
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ERK-MEK*

metaid_0000121
type: Parameter
constant: true
value: 1.2237
name: koff77

metaid_0000200
type: Parameter
constant: true
value: 1.9264E-4
name: kon66

metaid_0000164
type: Parameter
constant: true
value: 1.8012
name: kf12

metaid_0000433
type: Reaction
kinetic law: 841152
product: 841140
product: 841128
reactant: 841116
reactant: 841104
fast: false
reversible: true
name: Net E12/PTP1B Binding

841140
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

841128
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000338

metaid_0000338
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-PTP-1B

841116
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000336

841104
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000258

metaid_0000185
type: Parameter
constant: true
value: 0.0074
name: kon28

metaid_0000045
type: Parameter
constant: true
value: 675.2994
name: Kmr52

metaid_0000066
type: Parameter
constant: true
value: 0.0973
name: HRGoff_4

metaid_0000329
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-Shc

metaid_0000018
type: Parameter
constant: true
value: 749.9716
name: ERK_Abund

metaid_0000370
type: Reaction
kinetic law: 836354
product: 836342
reactant: 836330
reactant: 836318
is version of: GO:0046983
fast: false
reversible: true
name: ErbB4 Homodimerization

836342
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000256

metaid_0000256
type: Species
constant: false
name: (HRG-Erb4)2
has only substance units: false
boundary condition: false
has part: Q02297
has part: Q15303
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243

836330
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000250

836318
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000250

metaid_0000039
type: Parameter
constant: true
value: 599.7076
name: Kmf51

metaid_0000229
type: Parameter
constant: true
value: 1.0E-16
name: eps

metaid_0000130
type: Parameter
constant: true
value: 242.6034
name: Vmaxr81

metaid_0000094
type: Parameter
constant: true
value: 1.2567
name: koff36

metaid_0000373
type: Reaction
kinetic law: 836499
modifier: 836487
product: 836475
reactant: 836463
is version of: GO:0006468
fast: false
reversible: true
name: Net E23 Phosphorylation

836475
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000259

836463
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000253

metaid_0000253
type: Species
in compartment: metaid_0000243
has part: P04626
has only substance units: false
initial concentration: NaN
has part: Q02297
boundary condition: false
has part: P21860
constant: false
initial amount: 0.0
name: HRG-ErbB3-ErbB2

metaid_0000011
type: Parameter
constant: true
value: 82.3
name: SOS_Abund

metaid_0000458
type: Reaction
kinetic law: 842559
product: 842547
reactant: 842534
reactant: 842522
fast: false
reversible: true
name: ERK binding to MEKstar

842547
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000358

842534
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000315

842522
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000356

metaid_0000194
type: Parameter
constant: true
value: 0.0602
name: kon35

metaid_0000201
type: Parameter
constant: true
value: 6.6667E-5
name: kon67

metaid_0000003
type: Parameter
constant: true
value: 274.0
name: ErbB1_Abund

metaid_0000222
type: Parameter
constant: true
value: 3.97
name: koff69

metaid_0000434
type: Reaction
kinetic law: 841212
product: 841200
product: 841188
reactant: 841176
reactant: 841164
fast: false
reversible: true
name: Net E23/PTP1B Binding

841200
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

841188
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000339

841176
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000336

841164
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000259

metaid_0000103
type: Parameter
constant: true
value: 0.4265
name: koff44

metaid_0000067
type: Parameter
constant: true
value: 0.1717
name: koff4

metaid_0000146
type: Parameter
constant: true
value: 369.2261
name: Vmaxr85

metaid_0000088
type: Parameter
constant: true
value: 4.9936
name: koff30

metaid_0000367
type: Reaction
kinetic law: 836209
product: 836197
reactant: 836185
reactant: 836173
is version of: GO:0046983
fast: false
reversible: true
name: ErbB2/ErbB3 Heterodimerization

836197
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000253

836185
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000245

836173
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000249

metaid_0000167
type: Parameter
constant: true
value: 1.3565
name: kf15

metaid_0000060
type: Parameter
constant: true
value: 389.1061
name: kf50

metaid_0000371
type: Reaction
kinetic law: 836402
modifier: 836390
product: 836378
reactant: 836366
is version of: GO:0006468
fast: false
reversible: true
name: Net E11 Phosphorylation

836378
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000257

836366
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000251

metaid_0000131
type: Parameter
constant: true
value: 485.2626
name: Kmf81

metaid_0000012
type: Parameter
constant: true
value: 43.1
name: Gab1_Abund

metaid_0000231
type: Parameter
constant: true
value: 99.9637
name: koff89

metaid_0000195
type: Parameter
constant: true
value: 0.0043
name: kon36

metaid_0000376
type: Reaction
kinetic law: 836643
modifier: 836631
product: 836619
reactant: 836607
fast: false
reversible: true
name: Net E44 Phosphorylation

836619
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000262

836607
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000256

metaid_0000097
type: Parameter
constant: true
value: 2.2988
name: koff66

metaid_0000104
type: Parameter
constant: true
value: 3.9967
name: koff45

metaid_0000415
type: Reaction
kinetic law: 839921
modifier: 839909
product: 839897
reactant: 839885
fast: false
reversible: true
name: Net Gab1 S/T Phosphorylation

839897
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000319

839885
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000268

metaid_0000125
type: Parameter
constant: true
value: 83.4465
name: kPTP38

metaid_0000204
type: Parameter
constant: true
value: 0.0051
name: kon41

metaid_0000006
type: Parameter
constant: true
value: 399.0
name: ErbB4_Abund

metaid_0000168
type: Parameter
constant: true
value: 0.9297
name: kf63

metaid_0000380
type: Reaction
kinetic law: 836993
reactant: 836909
product: 836933
modifier: 836969
name: Net E12P/Grb2 binding
fast: false
reactant: 836921
modifier: 836957
modifier: 836981
reversible: true
product: 836945

836909
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000258

836933
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000272

836921
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

836945
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

metaid_0000189
type: Parameter
constant: true
value: 0.0032
name: kon31

metaid_0000049
type: Parameter
constant: true
value: 944.7692
name: Kmr53

metaid_0000347
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E2_p-PTP-1B

metaid_0000140
type: Parameter
constant: true
value: 653.5184
name: Kmr83

metaid_0000161
type: Parameter
constant: true
value: 0.0039
name: kon57

metaid_0000021
type: Parameter
constant: true
value: 0.0259
name: kdeg

metaid_0000042
type: Parameter
constant: true
value: 0.7745
name: kf52

metaid_0000232
type: Parameter
constant: true
value: 20.0037
name: kcat90

metaid_0000134
type: Parameter
constant: true
value: 398.1931
name: Vmaxr82

metaid_0000377
type: Reaction
product: 836679
modifier: 836728
modifier: 836703
kinetic law: 836740
fast: false
reactant: 836655
product: 836691
modifier: 836715
name: Net E11P/Grb2 binding
reversible: true
reactant: 836667

836679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000269

metaid_0000269
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-Grb2

836655
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000257

836691
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

836667
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

metaid_0000098
type: Parameter
constant: true
value: 1.6142
name: koff67

metaid_0000416
type: Reaction
kinetic law: 839969
product: 839957
reactant: 839945
reactant: 839933
fast: false
reversible: true
name: Grb2 binding to P3_A

839957
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000321

839945
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000305

839933
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

metaid_0000015
type: Parameter
constant: true
value: 95.7
name: Ras_Abund

metaid_0000398
type: Reaction
product: 838368
kinetic law: 838405
reversible: true
product: 838380
reactant: 838356
reactant: 838344
modifier: 838392
name: Net E44P/RasGAP binding
fast: false

838368
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000290

838380
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

838356
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

838344
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000262

metaid_0000198
type: Parameter
constant: true
value: 0.0078
name: kon79

metaid_0000205
type: Parameter
constant: true
value: 0.0023
name: kon42

metaid_0000007
type: Parameter
constant: true
value: 82.4
name: Grb2_Abund

metaid_0000226
type: Parameter
constant: true
value: 2.2988
name: koff71

metaid_0000070
type: Parameter
constant: true
value: 8.0557
name: koff7

metaid_0000107
type: Parameter
constant: true
value: 2.8871
name: koff68

metaid_0000091
type: Parameter
constant: true
value: 1.2817
name: koff33

metaid_0000455
type: Reaction
fast: false
reactant: 842315
modifier: 842365
modifier: 842352
modifier: 842377
reversible: true
modifier: 842389
modifier: 842339
name: HRG in EC compartment
product: 842327
modifier: 842401
kinetic law: 842413

842315
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000354

842327
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000304

metaid_0000170
type: Parameter
constant: true
value: 0.0097
name: kon16

metaid_0000410
type: Reaction
name: Net RasGTP Production
kinetic law: 839583
reversible: true
fast: false
modifier: 839559
modifier: 839547
reactant: 839523
modifier: 839571
product: 839535

839523
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000309

839535
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000310

metaid_0000431
type: Reaction
reactant: 840983
product: 841007
reactant: 840971
kinetic law: 841031
name: Net E14/RasGAP Binding
reversible: true
fast: false
product: 840995
modifier: 841019

840983
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

841007
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

840971
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000327

840995
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000335

metaid_0000043
type: Parameter
constant: true
value: 199.2773
name: Vmaxr52

metaid_0000449
type: Reaction
kinetic law: 842016
product: 842003
reactant: 841990
reactant: 841977
fast: false
reversible: false
name: E11G Degradation

842003
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000263

841990
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

841977
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000269

metaid_0000064
type: Parameter
constant: true
value: 0.0175
name: EGF_off

metaid_0000143
type: Parameter
constant: true
value: 622.3847
name: Kmf84

metaid_0000425
type: Reaction
name: Net E13/Shc Binding
product: 840537
reactant: 840525
modifier: 840573
kinetic law: 840585
reactant: 840513
fast: false
reversible: true
modifier: 840561
product: 840549

840537
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000329

840525
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

840513
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000326

840549
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

metaid_0000135
type: Parameter
constant: true
value: 781.4374
name: Kmf82

metaid_0000451
type: Reaction
kinetic law: 842120
product: 842107
reactant: 842094
reactant: 842081
fast: false
reversible: false
name: E11R Degradation

842107
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

842094
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

842081
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000271

metaid_0000235
type: Parameter
constant: true
value: 0.2004
name: kcat92

metaid_0000016
type: Parameter
constant: true
value: 743.0
name: Raf_Abund

metaid_0000399
type: Reaction
modifier: 838525
name: Net Shc Phosphorylation
modifier: 838489
fast: false
modifier: 838465
kinetic law: 838549
modifier: 838501
reversible: true
modifier: 838537
reactant: 838417
modifier: 838477
modifier: 838453
modifier: 838513
product: 838429
modifier: 838441

838417
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

838429
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000296

metaid_0000199
type: Parameter
constant: true
value: 0.0123
name: kon65

metaid_0000419
type: Reaction
kinetic law: 840211
product: 840199
product: 840186
reactant: 840174
reactant: 840162
fast: false
reversible: true
name: SOS binding to SigG-A

840199
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000323

840186
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000320

840174
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000267

840162
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000299

metaid_0000108
type: Parameter
constant: true
value: 500.0
name: PTP1B_Abund

metaid_0000092
type: Parameter
constant: true
value: 3.2036
name: koff34

metaid_0000129
type: Parameter
constant: true
value: 1.361
name: kf81

metaid_0000171
type: Parameter
constant: true
value: 0.0049
name: kon17

metaid_0000456
type: Reaction
kinetic law: 842462
product: 842450
reactant: 842438
reactant: 842425
fast: false
reversible: true
name: ERK binding to MEKstar

842450
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000357

842438
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000315

842425
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000316

metaid_0000192
type: Parameter
constant: true
value: 0.0101
name: kon77

metaid_0000073
type: Parameter
constant: true
value: 0.4526
name: koff57

metaid_0000432
type: Reaction
kinetic law: 841092
product: 841080
product: 841068
reactant: 841056
reactant: 841043
fast: false
reversible: true
name: Net E11/PTP1B Binding

841080
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

841068
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000337

841056
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000336

841043
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000257

metaid_0000101
type: Parameter
constant: true
value: 3.5195
name: koff42

metaid_0000144
type: Parameter
constant: true
value: 258.4637
name: Kmr84

metaid_0000165
type: Parameter
constant: true
value: 0.8875
name: kf13

metaid_0000025
type: Parameter
constant: true
value: 483.8622
name: Kmr47

metaid_0000046
type: Parameter
constant: true
value: 0.6094
name: kf53

metaid_0000452
type: Reaction
kinetic law: 842172
product: 842159
reactant: 842146
reactant: 842133
fast: false
reversible: false
name: E11T Degradation

842159
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000336

842146
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

842133
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000337

metaid_0000236
type: Parameter
constant: true
value: 0.2003
name: kon93

metaid_0000138
type: Parameter
constant: true
value: 534.0531
name: Vmaxr83

metaid_0000019
type: Parameter
constant: true
value: 223.8776
name: VmaxPY

metaid_0000441
type: Reaction
kinetic law: 841611
modifier: 841599
product: 841587
reactant: 841575
fast: false
reversible: true
name: Net E2 S/T Phosphorylation

841587
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000347

841575
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000245

metaid_0000193
type: Parameter
constant: true
value: 1.0E-4
name: kon34

metaid_0000110
type: Parameter
constant: true
value: 78.204
name: kPTP11

metaid_0000074
type: Parameter
constant: true
value: 0.5737
name: koff16

metaid_0000095
type: Parameter
constant: true
value: 0.4059
name: koff37

metaid_0000374
type: Reaction
kinetic law: 836547
modifier: 836535
product: 836523
reactant: 836511
is version of: GO:0006468
fast: false
reversible: true
name: Net E34 Phosphorylation

836523
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000260

836511
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000254

metaid_0000174
type: Parameter
constant: true
value: 0.0896
name: kon19

metaid_0000459
type: Reaction
kinetic law: 842607
product: 842595
product: 842583
reactant: 842571
fast: false
reversible: false
name: ERKstar production

842595
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000315

842583
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000317

842571
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000358

metaid_0000202
type: Parameter
constant: true
value: 2.0E-4
name: kon80

metaid_0000004
type: Parameter
constant: true
value: 158.0
name: ErbB2_Abund

metaid_0000461
type: Reaction
kinetic law: 842703
product: 842691
product: 842679
reactant: 842667
fast: false
reversible: false
name: ERKstar dephosphorylation

842691
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000360

842679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000356

842667
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000361

metaid_0000435
type: Reaction
kinetic law: 841272
product: 841260
product: 841248
reactant: 841236
reactant: 841224
fast: false
reversible: true
name: Net E34/PTP1B Binding

841260
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

841248
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000340

841236
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000336

841224
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000260

metaid_0000047
type: Parameter
constant: true
value: 59.2314
name: Vmaxr53

metaid_0000068
type: Parameter
constant: true
value: 4.3985
name: koff5

metaid_0000147
type: Parameter
constant: true
value: 179.6486
name: Kmf85

metaid_0000429
type: Reaction
product: 840862
reactant: 840838
reversible: true
modifier: 840874
name: Net E14/Shc Binding
modifier: 840887
kinetic law: 840899
product: 840850
reactant: 840826
fast: false

840862
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

840838
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

840850
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000333

840826
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000327

metaid_0000139
type: Parameter
constant: true
value: 609.4766
name: Kmf83

metaid_0000040
type: Parameter
constant: true
value: 346.4779
name: Kmr51

metaid_0000239
type: Parameter
constant: true
value: 0.1993
name: kon95

metaid_0000230
type: Parameter
constant: true
value: 0.1997
name: kon89

metaid_0000401
type: Reaction
kinetic law: 838754
product: 838742
product: 838730
reactant: 838718
reactant: 838706
fast: false
reversible: true
name: Net Grb2/SOS binding

838742
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000323

838730
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000298

838718
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000267

838706
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000291

metaid_0000111
type: Parameter
constant: true
value: 11.4211
name: kPTP12

metaid_0000132
type: Parameter
constant: true
value: 323.4012
name: Kmr81

metaid_0000341
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-PTP-1B

metaid_0000211
type: Parameter
constant: true
value: 0.0215
name: kon58

metaid_0000096
type: Parameter
constant: true
value: 0.1185
name: koff65

metaid_0000375
type: Reaction
kinetic law: 836595
modifier: 836583
product: 836571
reactant: 836559
is version of: GO:0006468
fast: false
reversible: true
name: Net E24 Phosphorylation

836571
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000261

836559
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000255

metaid_0000175
type: Parameter
constant: true
value: 0.0478
name: kon20

metaid_0000196
type: Parameter
constant: true
value: 0.0791
name: kon37

metaid_0000077
type: Parameter
constant: true
value: 2.3361
name: koff19

metaid_0000436
type: Reaction
kinetic law: 841333
product: 841321
product: 841309
reactant: 841297
reactant: 841284
fast: false
reversible: true
name: Net E24/PTP1B Binding

841321
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000345

841309
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000341

841297
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000336

841284
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000261

metaid_0000105
type: Parameter
constant: true
value: 6.3059
name: koff58

metaid_0000148
type: Parameter
constant: true
value: 290.7667
name: Kmr85

metaid_0000169
type: Parameter
constant: true
value: 1.2083
name: kf64

metaid_0000381
type: Reaction
modifier: 837066
product: 837041
modifier: 837054
reversible: true
reactant: 837005
product: 837029
fast: false
reactant: 837017
kinetic law: 837079
name: Net E12P/Shc binding

837041
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

837005
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000258

837029
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000273

837017
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

metaid_0000029
type: Parameter
constant: true
value: 693.5786
name: PTEN

metaid_0000141
type: Parameter
constant: true
value: 4.6894
name: kf84

metaid_0000384
type: Reaction
modifier: 837318
fast: false
modifier: 837306
kinetic law: 837330
name: Net E23P/Shc binding
reactant: 837259
reversible: true
product: 837283
reactant: 837271
product: 837294

837259
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000259

837283
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000276

837271
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

837294
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

metaid_0000022
type: Parameter
constant: true
value: 24.6048
name: kf47

metaid_0000133
type: Parameter
constant: true
value: 6.9987
name: kf82

metaid_0000212
type: Parameter
constant: true
value: 0.0077
name: kon59

metaid_0000233
type: Parameter
constant: true
value: 0.1966
name: kon91

metaid_0000445
type: Reaction
kinetic law: 841806
modifier: 841793
product: 841780
reactant: 841767
fast: false
reversible: true
name: EGF binding to E1-PT

841780
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000349

841767
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000346

metaid_0000197
type: Parameter
constant: true
value: 0.0076
name: kon78

metaid_0000114
type: Parameter
constant: true
value: 60.2628
name: kPTP15

metaid_0000078
type: Parameter
constant: true
value: 0.6761
name: koff20

metaid_0000099
type: Parameter
constant: true
value: 3.1051
name: koff40

metaid_0000378
type: Reaction
modifier: 836813
modifier: 836801
reactant: 836764
product: 836788
name: Net E11P/Shc binding
kinetic law: 836825
reversible: true
fast: false
reactant: 836752
product: 836776

836764
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000264

836788
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000292

836752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000257

836776
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000270

metaid_0000178
type: Parameter
constant: true
value: 7.0E-4
name: kon22

metaid_0000206
type: Parameter
constant: true
value: 0.0127
name: kon43

metaid_0000409
type: Reaction
reversible: true
modifier: 839475
product: 839379
modifier: 839415
modifier: 839439
modifier: 839391
fast: false
modifier: 839487
modifier: 839403
modifier: 839463
reactant: 839367
modifier: 839427
kinetic law: 839511
name: Net PIP3 Production
modifier: 839499
modifier: 839451

839379
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000307

839367
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000306

metaid_0000008
type: Parameter
constant: true
value: 11.5
name: Shc_Abund

metaid_0000050
type: Parameter
constant: true
value: 0.0538
name: kf54

metaid_0000071
type: Parameter
constant: true
value: 9.1034
name: koff8

metaid_0000382
type: Reaction
name: Net E12P/RasGAP binding
product: 837127
reactant: 837103
fast: false
product: 837115
reactant: 837091
modifier: 837139
kinetic law: 837151
reversible: true

837127
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

837103
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000266

837115
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000274

837091
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000258

metaid_0000150
type: Parameter
constant: true
value: 1.0086E-4
name: kon1

metaid_0000411
type: Reaction
modifier: 839667
product: 839607
reactant: 839595
modifier: 839716
modifier: 839643
kinetic law: 839728
name: Net RasGAP Phosphorylation
fast: false
modifier: 839619
modifier: 839655
modifier: 839679
modifier: 839691
modifier: 839704
modifier: 839631
reversible: true

839607
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000311

839595
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000294

metaid_0000023
type: Parameter
constant: true
value: 590.5058
name: Vmaxr47

metaid_0000044
type: Parameter
constant: true
value: 545.4408
name: Kmf52