BIOMD0000000168
type: SBMLModel
is part of: hsa04110
parameter: metaid_0000003
is: MODEL3896909694
compartment: metaid_0000023
parameter: metaid_0000007
parameter: metaid_0000013
reaction: metaid_0000037
rule: metaid_0000044
parameter: metaid_0000010
occurs in: http://identifiers.org/taxonomy/2759
modified:
  W3 CDTF: Thu Aug 09 17:26:41 BST 2012
species: metaid_0000025
parameter: metaid_0000017
species: metaid_0000024
parameter: metaid_0000043
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
parameter: metaid_0000004
parameter: metaid_0000014
parameter: metaid_0000008
parameter: metaid_0000018
parameter: metaid_0000020
reaction: metaid_0000042
is described by: http://identifiers.org/pubmed/17886749
length unit: length
reaction: metaid_0000034
species: metaid_0000030
species: metaid_0000029
name: Obeyesekere1999_CellCycle
time units: metaid_0000027
species: metaid_0000028
parameter: metaid_0000011
is version of: GO:0000278
curated: true
reaction: metaid_0000038
area units: metaid_0000005
reaction: metaid_0000040
substance units: metaid_0000003
volume units: metaid_0000004
parameter: metaid_0000005
parameter: metaid_0000015
parameter: metaid_0000009
parameter: metaid_0000019
parameter: metaid_0000021
reaction: metaid_0000033
rule: metaid_0000031
rule: metaid_0000032
reaction: metaid_0000035
parameter: metaid_0000006
notes: The model reproduces the time profiles of the different species depicted in Fig 3a of the paper. Model successfully reproduced using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000012
parameter: metaid_0000022
reaction: metaid_0000036
species: metaid_0000027
species: metaid_0000026
reaction: metaid_0000039
reaction: metaid_0000041
parameter: metaid_0000016
created:
  W3 CDTF: Sun Mar 16 19:31:22 GMT 2008

metaid_0000003
type: Parameter
constant: true
value: 0.4
name: aD

metaid_0000023
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

metaid_0000007
type: Parameter
constant: true
value: 0.16
name: aE

metaid_0000013
type: Parameter
constant: true
value: 0.6
name: pS

metaid_0000037
type: Reaction
kinetic law: 077534
modifier: 077498
modifier: 077486
product: 077474
is version of: GO:0016311
fast: false
reversible: false
name: pRB-p dephosphorilation

metaid_0000028
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.7
in compartment: metaid_0000023
name: X

metaid_0000030
type: Species
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000023
name: RP

077474
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000027
type: Species
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.5
in compartment: metaid_0000023
name: R

metaid_0000010
type: Parameter
constant: true
value: 0.2
name: dE

metaid_0000025
type: Species
is version of: P24864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.6
in compartment: metaid_0000023
name: E

metaid_0000017
type: Parameter
constant: true
value: 0.6
name: qE

metaid_0000024
type: Species
is version of: P24385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.1
in compartment: metaid_0000023
name: D

metaid_0000043
type: Parameter
constant: false
value: 0.0

metaid_0000004
type: Parameter
constant: true
value: 0.05
name: k

metaid_0000014
type: Parameter
constant: true
value: 0.48
name: pD

metaid_0000008
type: Parameter
constant: true
value: 0.9
name: af

metaid_0000018
type: Parameter
constant: true
value: 0.08
name: aX

metaid_0000020
type: Parameter
constant: true
value: 0.528
name: g

metaid_0000042
type: Reaction
kinetic law: 077859
modifier: 077847
reactant: 077835
is version of: GO:0051726
fast: false
reversible: false
name: cycle break

077835
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000034
type: Reaction
kinetic law: 077378
modifier: 077366
modifier: 077354
reactant: 077342
is version of: GO:0008054
fast: false
reversible: false
name: cycD/CDK4 degradation

077342
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000029
type: Species
is version of: Q01094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000023
name: E2F

metaid_0000011
type: Parameter
constant: true
value: 0.48
name: pX

metaid_0000038
type: Reaction
is version of: GO:0006461
kinetic law: 077606
reactant: 077546
modifier: 077594
modifier: 077570
product: 077558
modifier: 077582
reversible: false
fast: false
name: pRB/E2F complex association

077546
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000026
type: Species
initial concentration: NaN
name: RS
has part: P06400
boundary condition: false
has only substance units: false
constant: false
has part: Q01094
in compartment: metaid_0000023
initial amount: 1.0

077558
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000040
type: Reaction
kinetic law: 077750
modifier: 077714
modifier: 077702
reactant: 077690
is version of: GO:0043624
fast: false
reversible: false
name: pRB/E2F complex deassociation via cycE/CDK2

077690
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000005
type: Parameter
constant: true
value: 6.3
name: GF

metaid_0000015
type: Parameter
constant: true
value: 0.6
name: qD

metaid_0000009
type: Parameter
constant: true
value: 1.5
name: theta

metaid_0000019
type: Parameter
constant: true
value: 0.2
name: f

metaid_0000021
type: Parameter
constant: true
value: 1.04
name: dX

metaid_0000033
type: Reaction
kinetic law: 077330
product: 077317
is version of: GO:0006412
fast: false
reversible: false
name: cycD/CDK4 synthesis

077317
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000035
type: Reaction
kinetic law: 077414
modifier: 077402
product: 077390
is version of: GO:0006412
fast: false
reversible: false
name: cycE/CDK2 synthesis

077390
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000006
type: Parameter
constant: true
value: 0.4
name: dD

metaid_0000012
type: Parameter
constant: true
value: 2.5
name: RT

metaid_0000022
type: Parameter
constant: true
value: 0.8
name: qX

metaid_0000036
type: Reaction
kinetic law: 077462
modifier: 077450
modifier: 077438
reactant: 077426
is version of: GO:0008054
fast: false
reversible: false
name: cycE/CDK2 degradation

077426
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000039
type: Reaction
kinetic law: 077678
modifier: 077642
modifier: 077630
reactant: 077618
is version of: GO:0043624
fast: false
reversible: false
name: pRB/E2F complex deassociation via cycD/CDK4

077618
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000041
type: Reaction
reversible: false
modifier: 077798
product: 077762
modifier: 077786
modifier: 077774
kinetic law: 077823
fast: false
name: cycle progression
is version of: GO:0051726

077762
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000016
type: Parameter
constant: true
value: 0.096
name: pE