BIOMD0000000165
type: SBMLModel
species: metaid_0000031
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notes: The model reproduces Fig 2B of the paper. Model successfully tested on MathSBML To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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reactant: 225585
is version of: GO:0006198
fast: false
reversible: true
name: cAMP_degradation

225621
type: LocalParameter
units: metaid_0000011
value: 5.0

225597
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

225585
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000033

metaid_0000045
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000026
name: light_spot

metaid_0000030
type: Species
has part: CHEBI:17552
initial concentration: 0.0
has part: IPR001019
constant: false
in compartment: metaid_0000026
boundary condition: false
name: Gsa_gdp
initial amount: NaN
has part: C00035
has only substance units: false

metaid_0000081
type: Reaction
kinetic law: 224436
product: 224423
reactant: 224411
reactant: 224399
is part of: GO:0031684
fast: false
reversible: true
name: Gs_reassociation

224449
type: LocalParameter
units: metaid_0000012
value: 1210.0

224423
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

224411
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

224399
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000086
type: Reaction
kinetic law: 224813
product: 224801
reactant: 224789
reactant: 224777
is version of: GO:0031690
fast: false
reversible: true
name: bind_L_b1AR

224839
type: LocalParameter
units: metaid_0000011
value: 285.0

224826
type: LocalParameter
units: metaid_0000012
value: 1000.0

224801
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

224789
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000036

224777
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000014
type: Parameter
constant: true
units: metaid_0000011
value: 2.5

metaid_0000015
type: Parameter
constant: false
units: metaid_0000009
value: NaN

223587
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

223575
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE

223563
type: SBMLUnit
exponent: -3.0
scale: 0
multipler: 1.0
kind: METRE

223551
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 0.001
kind: DIMENSIONLESS

metaid_0000090
type: Reaction
kinetic law: 225104
modifier: 225092
product: 225080
reactant: 225067
is version of: GO:0006171
fast: false
reversible: true
name: cAMP_synthesis_FskAC

225116
type: LocalParameter
units: metaid_0000010
value: 860.0

225080
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

225067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

metaid_0000063
type: Species
name: DMNB_cAMP
has only substance units: false
boundary condition: false
initial concentration: 3.01
constant: false
is: CHEBI:17489
initial amount: NaN
in compartment: metaid_0000026
is: C00575

metaid_0000022
type: Parameter
constant: false
units: metaid_0000009
value: NaN

metaid_0000021
type: Parameter
constant: true
units: metaid_0000011
value: 7.3

metaid_0000108
type: Parameter
constant: true
value: 0.1

metaid_0000109
type: Parameter
constant: true
value: 1.0

223515
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000019
type: Parameter
constant: true
units: metaid_0000013
value: 0.0

metaid_0000085
type: Reaction
kinetic law: 224741
product: 224729
reactant: 224716
reactant: 224704
is version of: GO:0004939
fast: false
reversible: true
name: bind_L_b1ARGs

224765
type: LocalParameter
units: metaid_0000011
value: 0.535714

224753
type: LocalParameter
units: metaid_0000012
value: 1000.0

224729
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

224716
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

224704
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

metaid_0000092
type: Reaction
kinetic law: 225188
product: 225176
reactant: 225164
reactant: 225152
is version of: GO:0008179
fast: false
reversible: true
name: bind_Gs_AC

225212
type: LocalParameter
units: metaid_0000011
value: 400.0

225200
type: LocalParameter
units: metaid_0000012
value: 1000.0

225176
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

225164
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

225152
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000072
type: Reaction
kinetic law: 223853
product: 223841
fast: false
reversible: true
name: add_propranolol

223841
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000073
type: Reaction
kinetic law: 223902
modifier: 223890
product: 223878
reactant: 223865
fast: false
reversible: true
name: cAMP_photolysis

223914
type: LocalParameter
units: metaid_0000012
value: 0.1

223878
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

223865
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000093
type: Reaction
kinetic law: 225248
product: 225236
reactant: 225224
fast: false
reversible: true
name: resens_bark

225260
type: LocalParameter
units: metaid_0000011
value: 0.0022

225236
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

225224
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000080
type: Reaction
kinetic law: 224375
product: 224363
reactant: 224351
is version of: GO:0003924
fast: false
reversible: true
name: Gs_gtp_hydrolysis

224387
type: LocalParameter
units: metaid_0000011
value: 0.8

224363
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

224351
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

W3 CDTF: Wed Oct 03 11:05:51 BST 2007

W3 CDTF: Thu Jul 05 15:50:40 BST 2012